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CO2019001895A2 - Formulación novedosa para administración por vía oral - Google Patents

Formulación novedosa para administración por vía oral

Info

Publication number
CO2019001895A2
CO2019001895A2 CONC2019/0001895A CO2019001895A CO2019001895A2 CO 2019001895 A2 CO2019001895 A2 CO 2019001895A2 CO 2019001895 A CO2019001895 A CO 2019001895A CO 2019001895 A2 CO2019001895 A2 CO 2019001895A2
Authority
CO
Colombia
Prior art keywords
oral administration
novel formulation
particles
pharmaceutical agent
formulation
Prior art date
Application number
CONC2019/0001895A
Other languages
English (en)
Inventor
Allen Greenspoon
Original Assignee
Allen Greenspoon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allen Greenspoon filed Critical Allen Greenspoon
Publication of CO2019001895A2 publication Critical patent/CO2019001895A2/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058Chewing gums
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4468Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/658Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/348Cannabaceae
    • A61K36/3482Cannabis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dispersion Chemistry (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Confectionery (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proporciona una formulación de goma de mascar administrable por vía oral que comprende una base de goma aceptable farmacéuticamente y partículas de un agente farmacéutico que varían en tamaño de aproximadamente 50 a aproximadamente 2000 µm, en donde la formulación comprende aproximadamente 0.5-30 % en peso de las partículas del agente farmacéutico. Se proporciona, además, una formulación líquida que comprende partículas de un agente farmacéutico.
CONC2019/0001895A 2016-07-28 2019-02-27 Formulación novedosa para administración por vía oral CO2019001895A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15/222,019 US9833408B1 (en) 2016-07-28 2016-07-28 Orally administrable formulation
PCT/CA2017/050904 WO2018018152A1 (en) 2016-07-28 2017-07-28 Novel orally administrable formulation

Publications (1)

Publication Number Publication Date
CO2019001895A2 true CO2019001895A2 (es) 2019-05-31

Family

ID=60451833

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0001895A CO2019001895A2 (es) 2016-07-28 2019-02-27 Formulación novedosa para administración por vía oral

Country Status (13)

Country Link
US (2) US9833408B1 (es)
EP (2) EP3490539B1 (es)
JP (2) JP7050777B2 (es)
AU (2) AU2017301239B2 (es)
BR (2) BR112019001572B1 (es)
CL (1) CL2019000209A1 (es)
CO (1) CO2019001895A2 (es)
CU (1) CU20190005A7 (es)
IL (1) IL264484A (es)
MX (1) MX383529B (es)
PE (1) PE20190738A1 (es)
WO (1) WO2018018152A1 (es)
ZA (2) ZA201901116B (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9833408B1 (en) * 2016-07-28 2017-12-05 Allen Greenspoon Orally administrable formulation
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
US11449887B2 (en) 2017-10-09 2022-09-20 American Express Travel Related Services Company, Inc. Systems and methods for loyalty point distribution
US11397962B2 (en) 2017-10-09 2022-07-26 American Express Travel Related Services Company, Inc. Loyalty point distributions using a decentralized loyalty ID
US11699166B2 (en) 2017-10-09 2023-07-11 American Express Travel Related Services Company, Inc. Multi-merchant loyalty point partnership
EP3745884A1 (en) 2018-01-31 2020-12-09 Canopy Holdings, Llc Hemp powder
WO2019195355A1 (en) * 2018-04-03 2019-10-10 Pure Green Tablet or composition having n-acyl ethanolamine and cannabinoid
EP3549579A1 (en) * 2018-04-03 2019-10-09 Sanofi Winthrop Industrie Oral gum formulation and fabrication process thereof
US11728995B2 (en) 2018-04-09 2023-08-15 American Express Travel Related Services Company, Inc. Reward point transfers using blockchain
US10783545B2 (en) 2018-04-19 2020-09-22 American Express Travel Related Services Company, Inc. Reward point redemption for cryptocurrency
WO2020061584A1 (en) * 2018-09-21 2020-03-26 Msb Holdings, Inc. Taste-masked dosage forms
US11040932B2 (en) 2018-10-10 2021-06-22 Treehouse Biotech, Inc. Synthesis of cannabigerol
US11154496B2 (en) * 2019-01-25 2021-10-26 Nordiccan A/S Cannabinoid chewing gum with polyvinyl acetate elastomer plasticizers
EP3914226A1 (en) * 2019-01-25 2021-12-01 NordicCan A/S Cannabinoid chewing gum with improved release of cannabinoids
US11191720B2 (en) 2019-01-25 2021-12-07 Nordiccan A/S Chewing gum with improved delivery of cannabinoids
WO2020151793A1 (en) * 2019-01-25 2020-07-30 Medcan Pharma A/S Chewing gum with improved delivery of cannabinoids
US11406593B2 (en) 2019-01-25 2022-08-09 Nordiccan A/S Cannabinoid chewing gum with high intensity sweeteners
AU2019425173B2 (en) * 2019-01-25 2023-01-05 Nordiccan A/S Cannabinoid chewing gum with polyvinyl acetate elastomer plasticizers
US11166910B2 (en) 2019-01-25 2021-11-09 Nordiccan A/S Cannabinoid chewing gum with sugar alcohols
EP3876742B1 (en) * 2019-01-25 2023-04-05 NordicCan A/S Cannabinoid chewing gum with high intensity sweeteners
US11013685B2 (en) * 2019-01-25 2021-05-25 Nordiccan A/S Cannabinoid chewing gum with improved release of cannabinoids
WO2020151791A1 (en) * 2019-01-25 2020-07-30 Medcan Pharma A/S Cannabinoid chewing gum with sugar alcohols
US10799450B2 (en) 2019-03-01 2020-10-13 Medcan Pharma A/S Tableted cannabinoid chewing gum with layered structure
US11471405B2 (en) 2019-03-01 2022-10-18 Nordiccan A/S Tableted chewing gum with enhanced delivery of cannabinoids
US11253473B2 (en) * 2019-03-01 2022-02-22 Nordiccan A/S Method of producing tableted cannabinoid chewing gum
US10933017B2 (en) 2019-03-01 2021-03-02 Nordiccan A/S Tableted cannabinoid chewing gum with polyvinyl acetate elastomer plasticizers
US11331309B2 (en) * 2019-06-05 2022-05-17 Cure Pharmaceutical Holding Corp. Methods and compositions for improving sleep
WO2021026557A1 (en) * 2019-08-02 2021-02-11 Advanced Female Technologies Llc Chewing gum compositions containing cannabinoids
WO2021084543A1 (en) * 2019-10-31 2021-05-06 M. Mustix Ltd Treatment of tooth decay using a chewing gum composition comprising cannabinoids
CA3160750A1 (en) 2019-12-09 2021-06-17 Anthony Richard Gerardi Oral product comprising a cannabinoid
WO2021116825A1 (en) * 2019-12-09 2021-06-17 Nicoventures Trading Limited Oral product
US11058142B1 (en) 2020-10-01 2021-07-13 Tobacco Technology, Inc. Shisha, heat-not-burn, or combustion casing with active ingredient, product and casing with active ingredient, and method of making the same
US11363834B2 (en) 2020-10-01 2022-06-21 Tobacco Technology, Inc. Shisha, heat-not-burn, or combustion casing, product, and method of making the same
WO2022103636A1 (en) * 2020-11-16 2022-05-19 Orcosa Inc. Improved use of cannabinoids in the treatment of alzheimer's disease
US11672761B2 (en) 2020-11-16 2023-06-13 Orcosa Inc. Rapidly infusing platform and compositions for therapeutic treatment in humans
US11839602B2 (en) 2020-11-25 2023-12-12 Nicoventures Trading Limited Oral cannabinoid product with lipid component
WO2023272335A1 (en) * 2021-06-30 2023-01-05 Emyria Cannabidiol formulation comprising a matrix pellet forming excipient
WO2023064318A1 (en) * 2021-10-11 2023-04-20 Natural Extraction Systems, LLC Biphasic compositions comprising one or both of carbonate and phosphate
WO2025043046A1 (en) * 2023-08-22 2025-02-27 GlycosBio, INC. Latex-compatible oil-based compositions
DK202330231A1 (en) * 2023-09-27 2025-04-10 Fertin Pharma As Cannabidiol for alleviating xerostomia

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816265A (en) * 1986-12-23 1989-03-28 Warner-Lambert Company Sweetener delivery systems containing polyvinyl acetate
DK505588D0 (da) * 1988-02-26 1988-09-09 Jesper Hamburger Middel og anvendelse af samme
US6132762A (en) * 1997-05-05 2000-10-17 Cristobal; Walter Transcutaneous application of marijuana
US7648696B2 (en) * 1999-08-20 2010-01-19 Unimed Pharmaceuticals, Llc Composition for inhalation comprising delta-9-tetrahydrocannabinol in a semiaqueous solvent
AU782991B2 (en) * 2000-03-09 2005-09-15 GW Research Limited Pharmaceutical compositions
BR0115989A (pt) * 2000-12-07 2004-01-13 Altana Pharma Ag Preparação farmacêutica na forma de uma suspensão compreendendo um ingrediente ativo instável a ácido
CZ306277B6 (cs) * 2001-02-14 2016-11-09 Gw Pharma Limited Pumpičkou aktivovaná kapalná sprejová formulace
DE10109763A1 (de) * 2001-02-28 2002-09-05 Gruenenthal Gmbh Pharmazeutische Salze
US6503532B1 (en) * 2001-04-13 2003-01-07 Murty Pharmaceuticals, Inc. Pharmaceutical composition containing tetrahydrocannabinol and a transdermal/transcutaneous delivery method thereof
GB2391865B (en) * 2002-08-14 2005-06-01 Gw Pharma Ltd Improvements in the extraction of pharmaceutically active components from plant materials
US6946150B2 (en) * 2002-08-14 2005-09-20 Gw Pharma Limited Pharmaceutical formulation
US8911751B2 (en) * 2005-10-11 2014-12-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions for nasal delivery
AU2007281918A1 (en) * 2006-08-04 2008-02-14 Insys Therapeutics Inc. Aqueous dronabinol formulations
WO2009020666A1 (en) * 2007-08-06 2009-02-12 Insys Therapeutics Inc. Oral cannabinoid liquid formulations and methods of treatment
DK2280687T3 (da) * 2008-03-26 2019-05-27 Stichting Sanammad Tyggegummisammensætninger omfattende cannabinoider
US20110166101A1 (en) * 2008-08-29 2011-07-07 Sun Pharma Advanced Research Company Limited Microparticles
JP5614571B2 (ja) * 2009-12-25 2014-10-29 ダイヤ製薬株式会社 咀嚼用ガム医薬品および咀嚼用ガム医薬品の製造方法
WO2012116445A1 (en) * 2011-02-28 2012-09-07 Technologies Khlôros Inc. Chewable vehicle for mouth absorption
WO2013009928A1 (en) * 2011-07-11 2013-01-17 Organic Medical Research Cannabinoid formulations
US9345771B2 (en) * 2012-10-04 2016-05-24 Insys Development Company, Inc. Oral cannabinoid formulations
US10071053B2 (en) * 2014-01-31 2018-09-11 Pocket Tea, Llc Tea composition for oral administration
US20160199299A1 (en) * 2015-01-09 2016-07-14 Mark B. Uren Cannabis Infused Chewing Composition
CN105124747B (zh) * 2015-07-21 2018-04-10 中国烟草总公司广东省公司 一种烟草提取物微粒和胶基型口香烟及其制备方法
CA3025559C (en) * 2016-05-27 2023-08-01 Medcan Pharma A/S Powdered composition comprising a complex between a cannabinoid and a basic ion exchange resin
US9833408B1 (en) * 2016-07-28 2017-12-05 Allen Greenspoon Orally administrable formulation
CA3028160C (en) * 2016-07-28 2021-03-30 Allen Greenspoon Orally administrable formulation

Also Published As

Publication number Publication date
AU2017301239A1 (en) 2019-03-14
AU2020257071B2 (en) 2021-03-25
PE20190738A1 (es) 2019-05-23
AU2020257071A1 (en) 2020-11-19
US9833408B1 (en) 2017-12-05
JP2019525963A (ja) 2019-09-12
EP4353221A2 (en) 2024-04-17
US10456357B2 (en) 2019-10-29
EP3490539A4 (en) 2020-08-12
BR112019001572B1 (pt) 2021-11-03
JP2022088537A (ja) 2022-06-14
BR122020007418B1 (pt) 2021-11-03
JP7050777B2 (ja) 2022-04-08
CU20190005A7 (es) 2020-03-04
ZA202001037B (en) 2020-07-29
ZA201901116B (en) 2020-10-28
EP4353221A3 (en) 2024-07-10
US20180064645A1 (en) 2018-03-08
BR112019001572A2 (pt) 2019-05-07
EP3490539A1 (en) 2019-06-05
AU2017301239B2 (en) 2020-10-08
CL2019000209A1 (es) 2019-09-27
MX2019001169A (es) 2019-08-29
MX383529B (es) 2025-03-14
IL264484A (en) 2019-02-28
EP3490539B1 (en) 2024-03-13
WO2018018152A1 (en) 2018-02-01

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