CO2019001895A2 - Formulación novedosa para administración por vía oral - Google Patents
Formulación novedosa para administración por vía oralInfo
- Publication number
- CO2019001895A2 CO2019001895A2 CONC2019/0001895A CO2019001895A CO2019001895A2 CO 2019001895 A2 CO2019001895 A2 CO 2019001895A2 CO 2019001895 A CO2019001895 A CO 2019001895A CO 2019001895 A2 CO2019001895 A2 CO 2019001895A2
- Authority
- CO
- Colombia
- Prior art keywords
- oral administration
- novel formulation
- particles
- pharmaceutical agent
- formulation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A61K9/0058—Chewing gums
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/348—Cannabaceae
- A61K36/3482—Cannabis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Pain & Pain Management (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dispersion Chemistry (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Confectionery (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se proporciona una formulación de goma de mascar administrable por vía oral que comprende una base de goma aceptable farmacéuticamente y partículas de un agente farmacéutico que varían en tamaño de aproximadamente 50 a aproximadamente 2000 µm, en donde la formulación comprende aproximadamente 0.5-30 % en peso de las partículas del agente farmacéutico. Se proporciona, además, una formulación líquida que comprende partículas de un agente farmacéutico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/222,019 US9833408B1 (en) | 2016-07-28 | 2016-07-28 | Orally administrable formulation |
| PCT/CA2017/050904 WO2018018152A1 (en) | 2016-07-28 | 2017-07-28 | Novel orally administrable formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2019001895A2 true CO2019001895A2 (es) | 2019-05-31 |
Family
ID=60451833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2019/0001895A CO2019001895A2 (es) | 2016-07-28 | 2019-02-27 | Formulación novedosa para administración por vía oral |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9833408B1 (es) |
| EP (2) | EP3490539B1 (es) |
| JP (2) | JP7050777B2 (es) |
| AU (2) | AU2017301239B2 (es) |
| BR (2) | BR112019001572B1 (es) |
| CL (1) | CL2019000209A1 (es) |
| CO (1) | CO2019001895A2 (es) |
| CU (1) | CU20190005A7 (es) |
| IL (1) | IL264484A (es) |
| MX (1) | MX383529B (es) |
| PE (1) | PE20190738A1 (es) |
| WO (1) | WO2018018152A1 (es) |
| ZA (2) | ZA201901116B (es) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9833408B1 (en) * | 2016-07-28 | 2017-12-05 | Allen Greenspoon | Orally administrable formulation |
| US10239808B1 (en) | 2016-12-07 | 2019-03-26 | Canopy Holdings, LLC | Cannabis extracts |
| US11449887B2 (en) | 2017-10-09 | 2022-09-20 | American Express Travel Related Services Company, Inc. | Systems and methods for loyalty point distribution |
| US11397962B2 (en) | 2017-10-09 | 2022-07-26 | American Express Travel Related Services Company, Inc. | Loyalty point distributions using a decentralized loyalty ID |
| US11699166B2 (en) | 2017-10-09 | 2023-07-11 | American Express Travel Related Services Company, Inc. | Multi-merchant loyalty point partnership |
| EP3745884A1 (en) | 2018-01-31 | 2020-12-09 | Canopy Holdings, Llc | Hemp powder |
| WO2019195355A1 (en) * | 2018-04-03 | 2019-10-10 | Pure Green | Tablet or composition having n-acyl ethanolamine and cannabinoid |
| EP3549579A1 (en) * | 2018-04-03 | 2019-10-09 | Sanofi Winthrop Industrie | Oral gum formulation and fabrication process thereof |
| US11728995B2 (en) | 2018-04-09 | 2023-08-15 | American Express Travel Related Services Company, Inc. | Reward point transfers using blockchain |
| US10783545B2 (en) | 2018-04-19 | 2020-09-22 | American Express Travel Related Services Company, Inc. | Reward point redemption for cryptocurrency |
| WO2020061584A1 (en) * | 2018-09-21 | 2020-03-26 | Msb Holdings, Inc. | Taste-masked dosage forms |
| US11040932B2 (en) | 2018-10-10 | 2021-06-22 | Treehouse Biotech, Inc. | Synthesis of cannabigerol |
| US11154496B2 (en) * | 2019-01-25 | 2021-10-26 | Nordiccan A/S | Cannabinoid chewing gum with polyvinyl acetate elastomer plasticizers |
| EP3914226A1 (en) * | 2019-01-25 | 2021-12-01 | NordicCan A/S | Cannabinoid chewing gum with improved release of cannabinoids |
| US11191720B2 (en) | 2019-01-25 | 2021-12-07 | Nordiccan A/S | Chewing gum with improved delivery of cannabinoids |
| WO2020151793A1 (en) * | 2019-01-25 | 2020-07-30 | Medcan Pharma A/S | Chewing gum with improved delivery of cannabinoids |
| US11406593B2 (en) | 2019-01-25 | 2022-08-09 | Nordiccan A/S | Cannabinoid chewing gum with high intensity sweeteners |
| AU2019425173B2 (en) * | 2019-01-25 | 2023-01-05 | Nordiccan A/S | Cannabinoid chewing gum with polyvinyl acetate elastomer plasticizers |
| US11166910B2 (en) | 2019-01-25 | 2021-11-09 | Nordiccan A/S | Cannabinoid chewing gum with sugar alcohols |
| EP3876742B1 (en) * | 2019-01-25 | 2023-04-05 | NordicCan A/S | Cannabinoid chewing gum with high intensity sweeteners |
| US11013685B2 (en) * | 2019-01-25 | 2021-05-25 | Nordiccan A/S | Cannabinoid chewing gum with improved release of cannabinoids |
| WO2020151791A1 (en) * | 2019-01-25 | 2020-07-30 | Medcan Pharma A/S | Cannabinoid chewing gum with sugar alcohols |
| US10799450B2 (en) | 2019-03-01 | 2020-10-13 | Medcan Pharma A/S | Tableted cannabinoid chewing gum with layered structure |
| US11471405B2 (en) | 2019-03-01 | 2022-10-18 | Nordiccan A/S | Tableted chewing gum with enhanced delivery of cannabinoids |
| US11253473B2 (en) * | 2019-03-01 | 2022-02-22 | Nordiccan A/S | Method of producing tableted cannabinoid chewing gum |
| US10933017B2 (en) | 2019-03-01 | 2021-03-02 | Nordiccan A/S | Tableted cannabinoid chewing gum with polyvinyl acetate elastomer plasticizers |
| US11331309B2 (en) * | 2019-06-05 | 2022-05-17 | Cure Pharmaceutical Holding Corp. | Methods and compositions for improving sleep |
| WO2021026557A1 (en) * | 2019-08-02 | 2021-02-11 | Advanced Female Technologies Llc | Chewing gum compositions containing cannabinoids |
| WO2021084543A1 (en) * | 2019-10-31 | 2021-05-06 | M. Mustix Ltd | Treatment of tooth decay using a chewing gum composition comprising cannabinoids |
| CA3160750A1 (en) | 2019-12-09 | 2021-06-17 | Anthony Richard Gerardi | Oral product comprising a cannabinoid |
| WO2021116825A1 (en) * | 2019-12-09 | 2021-06-17 | Nicoventures Trading Limited | Oral product |
| US11058142B1 (en) | 2020-10-01 | 2021-07-13 | Tobacco Technology, Inc. | Shisha, heat-not-burn, or combustion casing with active ingredient, product and casing with active ingredient, and method of making the same |
| US11363834B2 (en) | 2020-10-01 | 2022-06-21 | Tobacco Technology, Inc. | Shisha, heat-not-burn, or combustion casing, product, and method of making the same |
| WO2022103636A1 (en) * | 2020-11-16 | 2022-05-19 | Orcosa Inc. | Improved use of cannabinoids in the treatment of alzheimer's disease |
| US11672761B2 (en) | 2020-11-16 | 2023-06-13 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
| US11839602B2 (en) | 2020-11-25 | 2023-12-12 | Nicoventures Trading Limited | Oral cannabinoid product with lipid component |
| WO2023272335A1 (en) * | 2021-06-30 | 2023-01-05 | Emyria | Cannabidiol formulation comprising a matrix pellet forming excipient |
| WO2023064318A1 (en) * | 2021-10-11 | 2023-04-20 | Natural Extraction Systems, LLC | Biphasic compositions comprising one or both of carbonate and phosphate |
| WO2025043046A1 (en) * | 2023-08-22 | 2025-02-27 | GlycosBio, INC. | Latex-compatible oil-based compositions |
| DK202330231A1 (en) * | 2023-09-27 | 2025-04-10 | Fertin Pharma As | Cannabidiol for alleviating xerostomia |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816265A (en) * | 1986-12-23 | 1989-03-28 | Warner-Lambert Company | Sweetener delivery systems containing polyvinyl acetate |
| DK505588D0 (da) * | 1988-02-26 | 1988-09-09 | Jesper Hamburger | Middel og anvendelse af samme |
| US6132762A (en) * | 1997-05-05 | 2000-10-17 | Cristobal; Walter | Transcutaneous application of marijuana |
| US7648696B2 (en) * | 1999-08-20 | 2010-01-19 | Unimed Pharmaceuticals, Llc | Composition for inhalation comprising delta-9-tetrahydrocannabinol in a semiaqueous solvent |
| AU782991B2 (en) * | 2000-03-09 | 2005-09-15 | GW Research Limited | Pharmaceutical compositions |
| BR0115989A (pt) * | 2000-12-07 | 2004-01-13 | Altana Pharma Ag | Preparação farmacêutica na forma de uma suspensão compreendendo um ingrediente ativo instável a ácido |
| CZ306277B6 (cs) * | 2001-02-14 | 2016-11-09 | Gw Pharma Limited | Pumpičkou aktivovaná kapalná sprejová formulace |
| DE10109763A1 (de) * | 2001-02-28 | 2002-09-05 | Gruenenthal Gmbh | Pharmazeutische Salze |
| US6503532B1 (en) * | 2001-04-13 | 2003-01-07 | Murty Pharmaceuticals, Inc. | Pharmaceutical composition containing tetrahydrocannabinol and a transdermal/transcutaneous delivery method thereof |
| GB2391865B (en) * | 2002-08-14 | 2005-06-01 | Gw Pharma Ltd | Improvements in the extraction of pharmaceutically active components from plant materials |
| US6946150B2 (en) * | 2002-08-14 | 2005-09-20 | Gw Pharma Limited | Pharmaceutical formulation |
| US8911751B2 (en) * | 2005-10-11 | 2014-12-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions for nasal delivery |
| AU2007281918A1 (en) * | 2006-08-04 | 2008-02-14 | Insys Therapeutics Inc. | Aqueous dronabinol formulations |
| WO2009020666A1 (en) * | 2007-08-06 | 2009-02-12 | Insys Therapeutics Inc. | Oral cannabinoid liquid formulations and methods of treatment |
| DK2280687T3 (da) * | 2008-03-26 | 2019-05-27 | Stichting Sanammad | Tyggegummisammensætninger omfattende cannabinoider |
| US20110166101A1 (en) * | 2008-08-29 | 2011-07-07 | Sun Pharma Advanced Research Company Limited | Microparticles |
| JP5614571B2 (ja) * | 2009-12-25 | 2014-10-29 | ダイヤ製薬株式会社 | 咀嚼用ガム医薬品および咀嚼用ガム医薬品の製造方法 |
| WO2012116445A1 (en) * | 2011-02-28 | 2012-09-07 | Technologies Khlôros Inc. | Chewable vehicle for mouth absorption |
| WO2013009928A1 (en) * | 2011-07-11 | 2013-01-17 | Organic Medical Research | Cannabinoid formulations |
| US9345771B2 (en) * | 2012-10-04 | 2016-05-24 | Insys Development Company, Inc. | Oral cannabinoid formulations |
| US10071053B2 (en) * | 2014-01-31 | 2018-09-11 | Pocket Tea, Llc | Tea composition for oral administration |
| US20160199299A1 (en) * | 2015-01-09 | 2016-07-14 | Mark B. Uren | Cannabis Infused Chewing Composition |
| CN105124747B (zh) * | 2015-07-21 | 2018-04-10 | 中国烟草总公司广东省公司 | 一种烟草提取物微粒和胶基型口香烟及其制备方法 |
| CA3025559C (en) * | 2016-05-27 | 2023-08-01 | Medcan Pharma A/S | Powdered composition comprising a complex between a cannabinoid and a basic ion exchange resin |
| US9833408B1 (en) * | 2016-07-28 | 2017-12-05 | Allen Greenspoon | Orally administrable formulation |
| CA3028160C (en) * | 2016-07-28 | 2021-03-30 | Allen Greenspoon | Orally administrable formulation |
-
2016
- 2016-07-28 US US15/222,019 patent/US9833408B1/en active Active
-
2017
- 2017-07-28 PE PE2019000281A patent/PE20190738A1/es unknown
- 2017-07-28 BR BR112019001572-8A patent/BR112019001572B1/pt not_active IP Right Cessation
- 2017-07-28 BR BR122020007418-3A patent/BR122020007418B1/pt active IP Right Grant
- 2017-07-28 WO PCT/CA2017/050904 patent/WO2018018152A1/en not_active Ceased
- 2017-07-28 EP EP17833153.4A patent/EP3490539B1/en active Active
- 2017-07-28 JP JP2019526350A patent/JP7050777B2/ja not_active Expired - Fee Related
- 2017-07-28 EP EP24160275.4A patent/EP4353221A3/en not_active Withdrawn
- 2017-07-28 AU AU2017301239A patent/AU2017301239B2/en not_active Ceased
- 2017-07-28 MX MX2019001169A patent/MX383529B/es unknown
- 2017-07-28 CU CU2019000005A patent/CU20190005A7/es unknown
- 2017-11-08 US US15/806,928 patent/US10456357B2/en active Active
-
2019
- 2019-01-25 CL CL2019000209A patent/CL2019000209A1/es unknown
- 2019-01-27 IL IL264484A patent/IL264484A/en unknown
- 2019-02-21 ZA ZA2019/01116A patent/ZA201901116B/en unknown
- 2019-02-27 CO CONC2019/0001895A patent/CO2019001895A2/es unknown
-
2020
- 2020-02-19 ZA ZA2020/01037A patent/ZA202001037B/en unknown
- 2020-10-21 AU AU2020257071A patent/AU2020257071B2/en not_active Ceased
-
2022
- 2022-03-29 JP JP2022054535A patent/JP2022088537A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017301239A1 (en) | 2019-03-14 |
| AU2020257071B2 (en) | 2021-03-25 |
| PE20190738A1 (es) | 2019-05-23 |
| AU2020257071A1 (en) | 2020-11-19 |
| US9833408B1 (en) | 2017-12-05 |
| JP2019525963A (ja) | 2019-09-12 |
| EP4353221A2 (en) | 2024-04-17 |
| US10456357B2 (en) | 2019-10-29 |
| EP3490539A4 (en) | 2020-08-12 |
| BR112019001572B1 (pt) | 2021-11-03 |
| JP2022088537A (ja) | 2022-06-14 |
| BR122020007418B1 (pt) | 2021-11-03 |
| JP7050777B2 (ja) | 2022-04-08 |
| CU20190005A7 (es) | 2020-03-04 |
| ZA202001037B (en) | 2020-07-29 |
| ZA201901116B (en) | 2020-10-28 |
| EP4353221A3 (en) | 2024-07-10 |
| US20180064645A1 (en) | 2018-03-08 |
| BR112019001572A2 (pt) | 2019-05-07 |
| EP3490539A1 (en) | 2019-06-05 |
| AU2017301239B2 (en) | 2020-10-08 |
| CL2019000209A1 (es) | 2019-09-27 |
| MX2019001169A (es) | 2019-08-29 |
| MX383529B (es) | 2025-03-14 |
| IL264484A (en) | 2019-02-28 |
| EP3490539B1 (en) | 2024-03-13 |
| WO2018018152A1 (en) | 2018-02-01 |
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