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CO2018000235A2 - Anticuerpo anti-receptor de transferrina humana que penetra la barrera hematoencefálica - Google Patents

Anticuerpo anti-receptor de transferrina humana que penetra la barrera hematoencefálica

Info

Publication number
CO2018000235A2
CO2018000235A2 CONC2018/0000235A CO2018000235A CO2018000235A2 CO 2018000235 A2 CO2018000235 A2 CO 2018000235A2 CO 2018000235 A CO2018000235 A CO 2018000235A CO 2018000235 A2 CO2018000235 A2 CO 2018000235A2
Authority
CO
Colombia
Prior art keywords
brain barrier
blood brain
receptor antibody
transferrin receptor
human transferrin
Prior art date
Application number
CONC2018/0000235A
Other languages
English (en)
Inventor
Hiroyuki Sonoda
Kenichi Takahashi
Original Assignee
Japan Chem Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57585554&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO2018000235(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Japan Chem Res filed Critical Japan Chem Res
Publication of CO2018000235A2 publication Critical patent/CO2018000235A2/es

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    • C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
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Abstract

Se da a conocer un medio para convertir compuestos, los cuales tienen actividad fisiológica o farmacológica y son incapaces de pasar a través de la barrera hematoencefálica, a una forma que les permite pasar a través de la barrera hematoencefálica, así como compuestos convertidos de ese modo. El medio es un anticuerpo anti-receptor de transferrina humana, y los compuestos convertidos son conjugados moleculares entre una proteína fisiológicamente activa o un compuesto de bajo peso molecular farmacológicamente activo y un anticuerpo anti-receptor de transferrina humana.
CONC2018/0000235A 2015-06-24 2018-01-12 Anticuerpo anti-receptor de transferrina humana que penetra la barrera hematoencefálica CO2018000235A2 (es)

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US11584793B2 (en) 2015-06-24 2023-02-21 Hoffmann-La Roche Inc. Anti-transferrin receptor antibodies with tailored affinity
US12252533B2 (en) 2015-06-24 2025-03-18 Hoffmann-La Roche Inc. Anti-transferrin receptor antibodies with tailored affinity
US11603411B2 (en) 2015-10-02 2023-03-14 Hoffmann-La Roche Inc. Bispecific anti-human CD20/human transferrin receptor antibodies and methods of use
US12030952B2 (en) 2015-10-02 2024-07-09 Hoffmann-La Roche Inc. Bispecific anti-human CD20/human transferrin receptor antibodies and methods of use

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