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CO2017008816A2 - Compuestos de benzoxaborol y usos de los mismos - Google Patents

Compuestos de benzoxaborol y usos de los mismos

Info

Publication number
CO2017008816A2
CO2017008816A2 CONC2017/0008816A CO2017008816A CO2017008816A2 CO 2017008816 A2 CO2017008816 A2 CO 2017008816A2 CO 2017008816 A CO2017008816 A CO 2017008816A CO 2017008816 A2 CO2017008816 A2 CO 2017008816A2
Authority
CO
Colombia
Prior art keywords
compounds
structure comprises
whose structure
comprises formula
benzoxaborol compounds
Prior art date
Application number
CONC2017/0008816A
Other languages
English (en)
Inventor
M R K Alley (Dickon)
Jacob J Plattner
Xianfeng Li
David Barros-Aguirre
Ilaria Giordano
Vincent Hernandez
Original Assignee
Glaxosmithkline Ip No 2 Ltd
Anacor Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55409879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO2017008816(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Ip No 2 Ltd, Anacor Pharmaceuticals Inc filed Critical Glaxosmithkline Ip No 2 Ltd
Publication of CO2017008816A2 publication Critical patent/CO2017008816A2/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/08Antibacterial agents for leprosy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/04Esters of boric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Se proporcionan compuestos cuya estructura comprende la fórmula II o un compuesto cuya estructura comprende la fórmula III, en donde X se selecciona a partir de cloro, flúor, bromo y yodo, R1 y R2 se seleccionan cada uno independientemente a partir de H, -CH3, -CH2CH3, –CH2CH2CH3, o -CH(CH3)2; composiciones que los contienen, su uso en terapia, incluyendo su uso como agentes anti-micobacterianos, por ejemplo, en el tratamiento de una infección micobacteriana en un mamífero, y los métodos para la preparación de estos compuestos.
CONC2017/0008816A 2015-02-12 2017-08-29 Compuestos de benzoxaborol y usos de los mismos CO2017008816A2 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP15382055 2015-02-12
EP15382054 2015-02-12
EP15382056 2015-02-12
PCT/IB2016/050776 WO2016128949A1 (en) 2015-02-12 2016-02-12 Benzoxaborole compounds and uses thereof

Publications (1)

Publication Number Publication Date
CO2017008816A2 true CO2017008816A2 (es) 2017-11-10

Family

ID=55409879

Family Applications (2)

Application Number Title Priority Date Filing Date
CONC2017/0008816A CO2017008816A2 (es) 2015-02-12 2017-08-29 Compuestos de benzoxaborol y usos de los mismos
CONC2017/0008809A CO2017008809A2 (es) 2015-02-12 2017-08-29 Compuestos de benzoxaborol y uso de los mismos

Family Applications After (1)

Application Number Title Priority Date Filing Date
CONC2017/0008809A CO2017008809A2 (es) 2015-02-12 2017-08-29 Compuestos de benzoxaborol y uso de los mismos

Country Status (36)

Country Link
US (3) US10774096B2 (es)
EP (2) EP3256480A1 (es)
JP (2) JP2018506540A (es)
KR (2) KR20170117156A (es)
CN (2) CN107548398A (es)
AU (3) AU2016217508A1 (es)
BR (2) BR112017017213A2 (es)
CA (2) CA2976030C (es)
CL (2) CL2017002059A1 (es)
CO (2) CO2017008816A2 (es)
CR (2) CR20170371A (es)
CY (1) CY1123687T1 (es)
DK (1) DK3256479T3 (es)
DO (2) DOP2017000188A (es)
EA (2) EA036516B1 (es)
ES (1) ES2821951T3 (es)
HR (1) HRP20201597T1 (es)
HU (1) HUE051113T2 (es)
IL (2) IL253865A0 (es)
LT (1) LT3256479T (es)
MA (2) MA41494B1 (es)
MX (2) MX2017010414A (es)
MY (1) MY194004A (es)
NZ (1) NZ734379A (es)
PE (2) PE20171348A1 (es)
PH (2) PH12017501428A1 (es)
PL (1) PL3256479T3 (es)
PT (1) PT3256479T (es)
RS (1) RS60885B1 (es)
SG (2) SG11201706510YA (es)
SI (1) SI3256479T1 (es)
SM (1) SMT202000565T1 (es)
TW (2) TW201702250A (es)
UA (1) UA120527C2 (es)
WO (2) WO2016128948A1 (es)
ZA (1) ZA201705456B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3030519B1 (en) * 2013-08-09 2022-01-05 Glaxosmithkline Intellectual Property (No. 2) Limited Tricyclic benzoxaborole compounds and uses thereof
BR112019023322B1 (pt) 2017-05-08 2023-11-14 Glaxosmithkline Intellectual Property Development Limited Uso do sanfetrinem, sanfetrinem sódico ou sanfetrinem cilexetila para a produção de um medicamento para o tratamento de tuberculose e combinação de sanfetrinem
CA3120976A1 (en) 2017-11-30 2019-06-06 Boragen, Inc. Benzoxaborole compounds and formulations thereof
AU2019325436B2 (en) 2018-08-18 2023-10-26 5Metis, Inc. Solid forms of substituted benzoxaborole and compositions thereof
CN110441344B (zh) * 2019-06-25 2020-09-29 北京大学 一种基于固体核磁共振技术检测rna结构的方法
EP4384527A4 (en) * 2022-06-23 2025-09-03 Micurx Pharmaceuticals Inc PRODRUGS OF BORON COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS
JP2025520237A (ja) * 2022-06-23 2025-07-03 ミクウルク ファーマシューティカルズ, インコーポレイテッド ホウ素化合物を用いて非結核性マイコバクテリア感染症を治療する方法及びその用途、並びに同じ疾患を治療するための医薬組成物
KR20240150582A (ko) 2023-04-08 2024-10-15 김태서 맥세이프 배터리팩을 포함한 아이폰 케이스

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GB9411587D0 (en) * 1994-06-09 1994-08-03 Zeneca Ltd Compound, composition and use
EP0947498B1 (en) 1996-12-02 2004-09-15 Chisso Corporation Optically active nitro alcohol derivatives, optically active amino alcohol derivatives, and process for preparing the same
US7446236B2 (en) 2002-12-02 2008-11-04 Solvias Ag Catalytic hydrogenation of carbon-heteroatom double bonds
HUE026021T2 (en) 2005-02-16 2016-05-30 Anacor Pharmaceuticals Inc Biocidal boron phthalide (boronophthalide) compounds
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KR20140114380A (ko) * 2011-12-22 2014-09-26 미큐알엑스 파마슈티칼스, 인크. 항미생물 요법용 트리시클릭 붕소 화합물
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EP3030519B1 (en) * 2013-08-09 2022-01-05 Glaxosmithkline Intellectual Property (No. 2) Limited Tricyclic benzoxaborole compounds and uses thereof

Also Published As

Publication number Publication date
MA41495A (fr) 2017-12-19
MA41494B1 (fr) 2020-10-28
CR20170372A (es) 2017-10-19
US11214582B2 (en) 2022-01-04
IL253864B (en) 2021-07-29
HRP20201597T1 (hr) 2020-12-25
DOP2017000189A (es) 2018-02-15
WO2016128949A1 (en) 2016-08-18
CL2017002059A1 (es) 2018-03-16
CA2976308A1 (en) 2016-08-18
US20180044353A1 (en) 2018-02-15
IL253864A0 (en) 2017-09-28
PT3256479T (pt) 2020-10-22
SI3256479T1 (sl) 2020-11-30
US10774096B2 (en) 2020-09-15
MA41494A (fr) 2017-12-19
KR20170117158A (ko) 2017-10-20
BR112017017211A2 (pt) 2018-04-03
JP2018506538A (ja) 2018-03-08
JP2018506540A (ja) 2018-03-08
TWI730953B (zh) 2021-06-21
CL2017002060A1 (es) 2018-03-16
MY194004A (en) 2022-11-07
ZA201705456B (en) 2019-10-30
CN107548398A (zh) 2018-01-05
TW201702250A (zh) 2017-01-16
US20210053996A1 (en) 2021-02-25
DOP2017000188A (es) 2017-09-15
RS60885B1 (sr) 2020-11-30
AU2016217507A1 (en) 2017-09-28
CA2976030A1 (en) 2016-08-18
PL3256479T3 (pl) 2021-06-14
JP6771472B2 (ja) 2020-10-21
CO2017008809A2 (es) 2017-11-10
ES2821951T3 (es) 2021-04-28
PH12017501428A1 (en) 2018-01-15
CY1123687T1 (el) 2022-03-24
SG11201706510YA (en) 2017-09-28
US20180037595A1 (en) 2018-02-08
WO2016128948A1 (en) 2016-08-18
EP3256479B1 (en) 2020-07-29
AU2016217508A1 (en) 2017-09-28
BR112017017213A2 (pt) 2018-04-03
LT3256479T (lt) 2020-12-28
AU2020256369A1 (en) 2020-11-12
PE20171432A1 (es) 2017-09-26
PH12017501427A1 (en) 2018-01-15
BR112017017211B1 (pt) 2023-04-25
NZ734379A (en) 2023-06-30
EA201791671A1 (ru) 2018-02-28
PE20171348A1 (es) 2017-09-13
MX2017010413A (es) 2018-05-11
UA120527C2 (uk) 2019-12-26
TW201643173A (zh) 2016-12-16
EA036516B1 (ru) 2020-11-18
EP3256480A1 (en) 2017-12-20
KR20170117156A (ko) 2017-10-20
MX2017010414A (es) 2018-05-11
EA201791667A1 (ru) 2018-02-28
SG11201706511TA (en) 2017-09-28
SMT202000565T1 (it) 2020-11-10
CR20170371A (es) 2018-01-22
CN107531730A (zh) 2018-01-02
EP3256479A1 (en) 2017-12-20
IL253865A0 (en) 2017-10-31
HUE051113T2 (hu) 2021-01-28
MX379057B (es) 2025-03-10
AU2016217507B2 (en) 2019-03-14
CA2976030C (en) 2023-09-26
DK3256479T3 (da) 2020-11-02
CN107531730B (zh) 2020-08-07

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