CO2016005723A1 - Synthetic antimicrobial peptides for the treatment of skin infections and the process for obtaining them - Google Patents
Synthetic antimicrobial peptides for the treatment of skin infections and the process for obtaining themInfo
- Publication number
- CO2016005723A1 CO2016005723A1 CONC2016/0005723A CO2016005723A CO2016005723A1 CO 2016005723 A1 CO2016005723 A1 CO 2016005723A1 CO 2016005723 A CO2016005723 A CO 2016005723A CO 2016005723 A1 CO2016005723 A1 CO 2016005723A1
- Authority
- CO
- Colombia
- Prior art keywords
- peptides
- present
- obtaining
- treatment
- seq
- Prior art date
Links
- 102000044503 Antimicrobial Peptides Human genes 0.000 title 1
- 108700042778 Antimicrobial Peptides Proteins 0.000 title 1
- 206010040872 skin infection Diseases 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 101800002011 Amphipathic peptide Proteins 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a una nueva clase de péptidos catiónicos y anfipáticos que poseen actividad antimicrobiana. Los péptidos de la presente invención presentan la secuencia de aminoácidos, P3-B AILRKATRRLVKLIV-NH2 (SEQ ID No. 1: P3-B), P3-C AIWRKATRRLVKLIV-NH2 (SEQ ID No. 2: P3-C), bien sea construidos completa o parcialmente con aminoácidos en configuración estereoquímica D o configuración estereoquímica L, o combinaciones de éstas o también están las sales farmacéuticamente aceptables de los péptidos de esta invención. Dentro del alcance de la presente invención también están las composiciones farmacéuticas que contienen dichos péptidos con los vehículos o transportadores farmacéuticamente aceptables más adecuados dependiendo de la forma de dosificación elegida. La invención proporciona métodos para inhibir el crecimiento de bacterias por medio del contacto directo de los organismos con la cantidad inhibidora efectiva de los péptidos.The present invention relates to a new class of cationic and amphipathic peptides that possess antimicrobial activity. The peptides of the present invention have the amino acid sequence, P3-B AILRKATRRLVKLIV-NH2 (SEQ ID No. 1: P3-B), P3-C AIWRKATRRLVKLIV-NH2 (SEQ ID No. 2: P3-C), either constructed entirely or partially with amino acids in stereochemical configuration D or stereochemical configuration L, or combinations thereof or pharmaceutically acceptable salts of the peptides of this invention. Also within the scope of the present invention are pharmaceutical compositions containing said peptides with the most suitable pharmaceutically acceptable carriers or carriers depending on the dosage form chosen. The invention provides methods for inhibiting the growth of bacteria by direct contact of organisms with the effective inhibitory amount of the peptides.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CONC2016/0005723A CO2016005723A1 (en) | 2016-12-23 | 2016-12-23 | Synthetic antimicrobial peptides for the treatment of skin infections and the process for obtaining them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CONC2016/0005723A CO2016005723A1 (en) | 2016-12-23 | 2016-12-23 | Synthetic antimicrobial peptides for the treatment of skin infections and the process for obtaining them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2016005723A1 true CO2016005723A1 (en) | 2018-07-10 |
Family
ID=62814205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2016/0005723A CO2016005723A1 (en) | 2016-12-23 | 2016-12-23 | Synthetic antimicrobial peptides for the treatment of skin infections and the process for obtaining them |
Country Status (1)
| Country | Link |
|---|---|
| CO (1) | CO2016005723A1 (en) |
-
2016
- 2016-12-23 CO CONC2016/0005723A patent/CO2016005723A1/en unknown
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