CN2874467Y - Magnetic control chip micro mixer - Google Patents
Magnetic control chip micro mixer Download PDFInfo
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- CN2874467Y CN2874467Y CN 200520103143 CN200520103143U CN2874467Y CN 2874467 Y CN2874467 Y CN 2874467Y CN 200520103143 CN200520103143 CN 200520103143 CN 200520103143 U CN200520103143 U CN 200520103143U CN 2874467 Y CN2874467 Y CN 2874467Y
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Abstract
本实用新型涉及一种磁控芯片微混合器，包括：上表面设有至少一个环形微流道的基板；与环形微流道相连通的进样口和出样口；装入环形微流道内的磁性微粒子；覆盖于基板上表面的盖板；位于基板下方的带有控制器的磁搅拌器；磁搅拌器包括微型交变转速控制器和与之相连并由其控制的环形磁体。其优点在于：混合通道结构简单，加工容易，成本低廉，易与芯片其它系统实现集成化；通过场控粒子运动，形成可控制微区湍流混合；可在微小体积内完成秒级至毫秒级的快速混合，效率高；混合所需的时间和空间小，两液流流速和流速比范围较广，使用普适性好，易于批量生产。
The utility model relates to a magnetic control chip micro-mixer, which comprises: a substrate with at least one annular micro-flow channel on the upper surface; a sample inlet and a sample outlet connected with the annular micro-flow channel; magnetic microparticles; a cover plate covering the upper surface of the substrate; a magnetic stirrer with a controller located under the substrate; the magnetic stirrer includes a micro-alternating speed controller and a ring magnet connected to and controlled by it. Its advantages are: the structure of the mixing channel is simple, the processing is easy, the cost is low, and it is easy to realize integration with other systems on the chip; through the movement of field-controlled particles, it forms controllable micro-zone turbulent mixing; it can complete seconds to milliseconds in a small volume. Rapid mixing and high efficiency; the time and space required for mixing are small, the flow rate and flow rate ratio of the two liquid streams have a wide range, good universality of use, and easy mass production.
Description
Technical field
The utility model belongs to a kind of mixer in the analytical chemistry field, particularly relate to a kind of little mixing of magnetic control chip that in microchannel, realizes the microfluid rapid mixing based on magnetic particle by externally-applied magnetic field, can be used for the even mixing of two or more microfluids under the microscale condition in the chip analysis detection, be specially adapted to before the post in the chip piece-rate system and the post column derivatization reaction.
Background technology
The micro-total analysis notion that the early 1990s occurs is the revolution of analytical chemistry.It is by the semiconductor microactuator process technology, process 10～100 microns microchannel network in silicon, glass, quartz, Polymer Surface, by flow direction and the speed of controlling liquid in the network of microchannel, realize the integrated and microminiaturized analysis of target analytes from sample pretreatment, reaction, separation, detection.System compares with conventional analysis, the advantage of microfluidic analysis system is that analysis speed is fast, sample reagent consumes low, the pollution of intermediate link sum of errors is few etc., but simultaneously, the microminiaturization of system also brings some negative effects, as: because of the minimizing in passage length and aperture, having increased fluid and reached mixed uniformly difficulty, how to have realized the rapid mixing between microscale condition underflow fluid, is the previous important research direction of order.
1999, Britain Bessoth design and made thin layer separating liquid cake core micro-mixer (BessothF G, deMello A J, Manz A, Anal Commun 1999,36:213); This thin layer separating liquid cake core micro-mixer: on chip, make intensive, fine branched bottom, by liquid flow split being become a plurality of thin layer liquid streams, can shorten diffusion length between liquid stream, significantly reduce incorporation time, but the complex structure of mixer and passage thereof, difficulty of processing is big, is difficult for realizing integrated with other system of chip.
Calendar year 2001, U.S. Dertinger processed " Christmas tree " cake core micro-mixer (Dertinger SKW, Chiu DJ, Jeon N L, Whitesides G M, Anal Chem 2001,73:1240); Be somebody's turn to do " Christmas tree " cake core micro-mixer: channel configurations is multi-level channel network, each level is made of a plurality of parallel branches serpentine channel, parallel port number increases step by step, resemble " Christmas tree " shape, it provides one to utilize complicated microchannel network to realize the COMPLEX MIXED method of operating.
2002, U.S. Stroock invented chaos chip micro-mixer (stroock A D, Detinger SKW, Ajdari A, Mezie I, Stone H A, Whitesides G M, Science, 2002,295:647); This chaos chip micro-mixer: the convex ridge of processing various configurations in channel bottom, convex ridge and channel axis are to forming an angle, convex ridge for various flows to the low reynolds number fluid have different resistances, produce spiral flow of liquid stream in passage thus, can be embodied as the quick mixing of liquid in the passage.
Though above-mentioned these inventions are exquisite, the chip structure complexity, little difficulty of processing is big, the cost height, be difficult for the chip other system integrated, limited they as a universality unit in the developing application of chip.Annotate: the structure of above-mentioned 3 kinds of micro-mixers should simply be described herein, and defective
Summary of the invention
The utility model purpose is to have proposed a kind ofly under dark, the wide yardstick condition of micron order, realizes playing a significant role the magnetic control chip micro-mixer of the simple and easy rapid mixing of microfluid in the passage at the micro-fluidic chip analysis field by magnetic field force.
The technical solution of the utility model is as follows:
1, the magnetic control chip micro-mixer that provides of the utility model comprises:
One substrate 1, the upper surface of described substrate 1 are provided with at least one annular fluid channel 2, and the injection port 3 and the outlet 4 that are connected with described annular fluid channel 2; Magnetic particle 5 in the described annular fluid channel 2 of packing into; Be covered in the cover plate 21 on described substrate 1 upper surface, described cover plate 21 is provided with the through hole that communicates with described injection port 3 and outlet 4; And, be positioned at the magnetic stirrer that has controller of described substrate 1 below.
Described substrate 1 can be the substrate of silicon chip, glass, polymethylmethacrylate, dimethyl silicone polymer or metal material.Described annular fluid channel 2 can be 2-8; Annular the wide of fluid channel 2 is 20～1000 microns, dark 10～500 microns; Be provided with in the described annular fluid channel 2 and evenly stop fence 6.
The described magnetic stirrer that has controller comprises: a miniature alternation rotational speed governor 8 and be attached thereto and by the toroidal magnet 9 of these miniature alternation rotational speed governor 8 controls;
Described magnetic particle 5 is the ferromagnetism micropin that is coated with the micron diameter of superpolymer shell; Described magnetic particle is hydrophobic or water-soluble super paramagnetic nano level magnetic fluid or the strong magnetic body of Fe-Nd-B.
The magnetic control chip micro-mixer that the utility model provides has following advantage:
1, the hybrid channel is simple in structure, and handling ease is with low cost, and easy and other system of chip realizes integrated.
2, by a motion of control particle, form controllable microcell turbulent flow and mix; Can in small volume, finish the rapid mixing of second level, the efficient height to Millisecond.
3, it is little to mix required time and space, and two liquid flowing speeds and velocity ratio scope are wider, use universality good, are easy to produce in batches.
The principle of work of the magnetic control chip micro-mixer that the utility model provides is as follows:
Magnetic control chip micro-mixer of the present utility model is to control rotation, the stirring, mobile of magnetic particle in mixer by the variation of externally-applied magnetic field gradient, makes the multilayer laminar flow reach initiatively the purpose of turbulent flow mixing fast.
Control assembly the most frequently used and universal type in magnetic field of the present utility model is the annular Fe-Nd-B permanent magnet that is driven by DC micromotor; Perhaps use the small-sized magnetic stirring apparatus in laboratory; Also can formula by the customized strong alternation rotational speed governor of electromagnetic material specialized designs.
The magnetic particle that the utility model uses is a kind of ferromagnetism micropin of the micron diameter that is coated with the superpolymer shell of special making; Also can require to select super paramagnetic nano level magnetic fluid (hydrophobic or water-soluble) or the strong magnetic body of Fe-Nd-B according to analyzing.
The utility model microchip mixing pit is made up of substrate and cover plate.Material is silex glass, polymethylmethacrylate (PMMA) or dimethyl silicone polymer (PDMS) etc., and the method that adopts standard photoetching wet etching or mold pressing injection moulding is at substrate surface process fluid chamber or fluid slot, and bonding encapsulates.Form complete microfluidic circuit passage.
Description of drawings
Fig. 1 is a structural representation of the present utility model, also is the A-B cut-open view of Fig. 2;
Fig. 2 is the structural representation of substrate 1;
Fig. 3 is the structural representation that has the substrate 1 that stops fence 6;
Fig. 4 is the structural representation that has the substrate 1 of a plurality of (4) annular microchannel 2;
Wherein: substrate 1 annular fluid channel 2 injection ports 3
Outlet 4 cover plates 21 magnetic particles 5
Stop fence 6 miniature alternation rotational speed governor 8 toroidal magnets 9
Embodiment
Embodiment 1: preparation one deck photosensitivity material on the substrate 1 of silicon chip, glass or metal material, and the circular passage microstructured optical masks plate according to design carries out optical exposure, and the back of developing forms photosensitive figure on substrate 1.On substrate 1, prepare little 2 (annular fluid channel 2 can be 2-8) and input, the delivery channel ports (being injection port 3 and outlet 4) etc. in circular passage with wet etching or dry etching, substrate 1 with 21 pairs of above-mentioned preparations of cover plate carries out the bonding encapsulation, import prefabricated magnetic particle 5, one magnetic stirrer that has a controller is set below substrate 1, can carries out quick miniflow married operation.The described magnetic stirrer that has controller comprises: a miniature alternation rotational speed governor 8 and be attached thereto and by the toroidal magnet 9 of these miniature alternation rotational speed governor 8 controls.
Embodiment 2: according to the magnetic control chip micro-mixer structure that designs, prepare the precision die of corresponding plastics or rubber.Directly use little foundry engieering, prepare the annular microchannel structure of various plastics or rubber, the luggage of going forward side by side is joined and is encapsulated, and imports prefabricated super paramagnetic micropin, the alternating magnetic field that adds coupling outside mixer can carry out the rapid mixing operation to the multinomial laminar flow that enters device.
Embodiment 3: utilize the equidistant fixing a plurality of needles free to rotate (being magnetic particle 5) of MEMS process technology in the annular microchannel of micro-mixer of the present invention, the luggage of going forward side by side is joined and is encapsulated.Rely on the external magnetic field graded to produce moment of torsion rotation needle, drive microfluid break layer stream mode, realize in short-term, the simple and easy miniflow in little space mixes.
Embodiment 4: as shown in Figure 3, can in the annular fluid channel 2 of micro-mixer, evenly be provided with and stop fence 6, magnetic particle 5 can only be moved freely in a period of time and channel range, form the synchronous magnetic of many microcells and mix or design the mixing microcell that different magnetic field changes, realize the evaluating objects that asynchronous mixing and order are mixed.
Embodiment 5: in the multichannel magnetic control chip micro-mixer as described in Figure 4, can design and make microminiaturized array mixer, realize that by the magnetic field magnetic Circuit Design hyperchannel mixes simultaneously and order is mixed.
Embodiment 6: drive liquid stream by peristaltic pump and do clockwise or counterclockwise along circumference and move in the annular micro-mixer for preparing, by magnetic field control magnetic particle and liquid stream countercurrent movement, the sensitivity of solid-liquid contact the raising in immunoassay fast and fully, shortening the reaction time is very favourable technical approach.
Claims (8)
1, a kind of magnetic control chip micro-mixer is characterized in that, comprising:
One substrate (1), the upper surface of described substrate (1) are provided with at least one annular fluid channel (2), and injection port (3) that is connected with described annular fluid channel (2) and outlet (4); Magnetic particle (5) in the described annular fluid channel (2) of packing into; Be covered in the cover plate (21) on described substrate (1) upper surface, described cover plate (21) is provided with the through hole that communicates with described injection port (3) and outlet (4); And, be positioned at the magnetic stirrer that has controller of described substrate (1) below.
2, by the described magnetic control chip of claim 1 micro-mixer, it is characterized in that described substrate (1) is the substrate of silicon chip, glass, polymethylmethacrylate, dimethyl silicone polymer or metal material.
By the described magnetic control chip of claim 1 micro-mixer, it is characterized in that 3, described annular fluid channel (2) is 2-8.
4, by the described magnetic control chip of claim 1 micro-mixer, it is characterized in that the wide of described annular fluid channel (2) is 20～1000 microns, dark 10～500 microns.
5, by the described magnetic control chip of claim 1 micro-mixer, it is characterized in that the described magnetic stirrer that has controller comprises: a miniature alternation rotational speed governor (8) and be attached thereto and by the toroidal magnet (9) of this miniature alternating magnetic field controller (8) control
6, by the described magnetic control chip of claim 1 micro-mixer, it is characterized in that, be provided with in the described annular fluid channel (2) evenly to be provided with and stop fence (6).
By the described magnetic control chip of claim 1 micro-mixer, it is characterized in that 7, described magnetic particle (5) is the ferromagnetism micropin that is coated with the micron diameter of superpolymer shell.
8, by the described magnetic control chip of claim 1 micro-mixer, it is characterized in that described magnetic particle (5) is hydrophobic or water-soluble super paramagnetic nano level magnetic fluid or the strong magnetic body of Fe-Nd-B.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200520103143 CN2874467Y (en) | 2005-07-29 | 2005-07-29 | Magnetic control chip micro mixer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200520103143 CN2874467Y (en) | 2005-07-29 | 2005-07-29 | Magnetic control chip micro mixer |
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| CN2874467Y true CN2874467Y (en) | 2007-02-28 |
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| CN 200520103143 Expired - Fee Related CN2874467Y (en) | 2005-07-29 | 2005-07-29 | Magnetic control chip micro mixer |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102861526A (en) * | 2012-09-17 | 2013-01-09 | 江苏大学 | Flexible magnetomotive micro-mixing method and device of micro-fluidic chip |
| CN103472241A (en) * | 2008-01-21 | 2013-12-25 | 三星电子株式会社 | Thin-film layered centrifuge device and analysis method using the same |
| CN104162379A (en) * | 2014-07-30 | 2014-11-26 | 江苏大学 | Micro-fluidic chip magnetic-bead chaotic mixing method and apparatus |
| TWI477321B (en) * | 2012-12-28 | 2015-03-21 | Ind Tech Res Inst | Micro flow mixing apparatus and method thereof |
| CN105413546A (en) * | 2015-12-14 | 2016-03-23 | 沈阳理工大学 | Micro-fluidic mixing process and device |
| CN106179544A (en) * | 2016-07-14 | 2016-12-07 | 大连海事大学 | Portable immunomagnetic bead three-dimensional mixing device and method of use based on microfluidic chip |
| CN107983244A (en) * | 2018-01-03 | 2018-05-04 | 燕山大学 | Forced Mixing device |
| CN109590035A (en) * | 2018-12-04 | 2019-04-09 | 中国农业大学 | The preparation method and microfluid drive of micro-fluidic chip |
| CN109999930A (en) * | 2019-04-04 | 2019-07-12 | 中国科学院长春光学精密机械与物理研究所 | A kind of microfluidic active mixer and its chip system |
| CN111214991A (en) * | 2020-01-13 | 2020-06-02 | 清华大学 | A high-viscosity liquid automatic mixing device at room temperature |
| CN111468018A (en) * | 2020-04-16 | 2020-07-31 | 西南交通大学 | A flexible active micro-hybrid device integrated system and preparation method |
| CN112537031A (en) * | 2020-11-05 | 2021-03-23 | 北京化工大学 | 3D printing method and equipment for gradient polymer composite material |
| CN117225489A (en) * | 2023-09-13 | 2023-12-15 | 扬州大学 | Nanomagnetic fluid mixing and sorting device and its working method |
-
2005
- 2005-07-29 CN CN 200520103143 patent/CN2874467Y/en not_active Expired - Fee Related
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103472241A (en) * | 2008-01-21 | 2013-12-25 | 三星电子株式会社 | Thin-film layered centrifuge device and analysis method using the same |
| CN103472241B (en) * | 2008-01-21 | 2015-06-17 | 三星电子株式会社 | Thin-film layered centrifuge device and analysis method using the same |
| CN102861526A (en) * | 2012-09-17 | 2013-01-09 | 江苏大学 | Flexible magnetomotive micro-mixing method and device of micro-fluidic chip |
| TWI477321B (en) * | 2012-12-28 | 2015-03-21 | Ind Tech Res Inst | Micro flow mixing apparatus and method thereof |
| CN104162379A (en) * | 2014-07-30 | 2014-11-26 | 江苏大学 | Micro-fluidic chip magnetic-bead chaotic mixing method and apparatus |
| CN104162379B (en) * | 2014-07-30 | 2016-03-02 | 江苏大学 | A kind of micro-fluidic chip magnetic bead chaotic mixing method and device |
| CN105413546B (en) * | 2015-12-14 | 2020-02-14 | 沈阳理工大学 | Microfluid mixing process and mixing device |
| CN105413546A (en) * | 2015-12-14 | 2016-03-23 | 沈阳理工大学 | Micro-fluidic mixing process and device |
| CN106179544A (en) * | 2016-07-14 | 2016-12-07 | 大连海事大学 | Portable immunomagnetic bead three-dimensional mixing device and method of use based on microfluidic chip |
| CN106179544B (en) * | 2016-07-14 | 2018-07-06 | 大连海事大学 | Portable immunomagnetic bead three-dimensional mixing device and method of use based on microfluidic chip |
| CN107983244A (en) * | 2018-01-03 | 2018-05-04 | 燕山大学 | Forced Mixing device |
| CN107983244B (en) * | 2018-01-03 | 2020-09-11 | 燕山大学 | Forced mixer |
| CN109590035A (en) * | 2018-12-04 | 2019-04-09 | 中国农业大学 | The preparation method and microfluid drive of micro-fluidic chip |
| CN109999930A (en) * | 2019-04-04 | 2019-07-12 | 中国科学院长春光学精密机械与物理研究所 | A kind of microfluidic active mixer and its chip system |
| CN111214991A (en) * | 2020-01-13 | 2020-06-02 | 清华大学 | A high-viscosity liquid automatic mixing device at room temperature |
| CN111468018A (en) * | 2020-04-16 | 2020-07-31 | 西南交通大学 | A flexible active micro-hybrid device integrated system and preparation method |
| CN112537031A (en) * | 2020-11-05 | 2021-03-23 | 北京化工大学 | 3D printing method and equipment for gradient polymer composite material |
| CN117225489A (en) * | 2023-09-13 | 2023-12-15 | 扬州大学 | Nanomagnetic fluid mixing and sorting device and its working method |
| CN117225489B (en) * | 2023-09-13 | 2025-11-11 | 扬州大学 | Nanometer magnetic fluid mixing and sorting device and working method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20070228 Termination date: 20110729 |