CN222866498U - A control device and flow cytometer - Google Patents
A control device and flow cytometer Download PDFInfo
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- CN222866498U CN222866498U CN202421194760.6U CN202421194760U CN222866498U CN 222866498 U CN222866498 U CN 222866498U CN 202421194760 U CN202421194760 U CN 202421194760U CN 222866498 U CN222866498 U CN 222866498U
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Abstract
本实用新型的实施例提供了一种控制装置及流式细胞仪，涉及温控设备领域。该控制装置包括导热模块、温度检测模块、探测器模块以及调压模块，所述温度检测模块设置于所述导热模块，所述温度检测模块用于输出表征所述导热模块温度的信息，所述探测器模块设置于所述导热模块，所述调压模块和所述探测器模块连接，用于向所述探测器模块输出工作电压，所述调压模块和所述温度检测模块连接，用于获取温度信息，并根据所述温度信息调节所述工作电压。该控制装置能够降低探测器模块和传热导体受环境温度影响，提高控温精度，从而确保探测器模块温度检测的准确性。
The embodiment of the utility model provides a control device and a flow cytometer, which relate to the field of temperature control equipment. The control device includes a heat conduction module, a temperature detection module, a detector module and a voltage regulating module, wherein the temperature detection module is arranged on the heat conduction module, the temperature detection module is used to output information characterizing the temperature of the heat conduction module, the detector module is arranged on the heat conduction module, the voltage regulating module is connected to the detector module, and is used to output a working voltage to the detector module, the voltage regulating module is connected to the temperature detection module, and is used to obtain temperature information and adjust the working voltage according to the temperature information. The control device can reduce the influence of the ambient temperature on the detector module and the heat transfer conductor, improve the temperature control accuracy, and thus ensure the accuracy of the temperature detection of the detector module.
Description
Technical Field
The utility model relates to the field of temperature control equipment, in particular to a control device and a flow cytometer.
Background
The flow cytometer is a high-tech biomedical detection instrument which can rapidly and accurately detect multiple physical and biological characteristics of single cells at the same time. Flow cytometers typically include an optical system, a fluid flow system, a detection and data processing system, and the like. The stability of the sensor APD (avalanche photodiode) of the photoelectric acquisition part of the flow cytometer is important for the stable operation of the flow cytometer.
The flow cytometer in the prior art has the technical problems that the temperature stability of an avalanche photodiode is poor, and the detected temperature data is not accurate enough.
Disclosure of utility model
The utility model provides a control device and a flow cytometer, which can improve the temperature stability of an avalanche photodiode and improve the accuracy of temperature data detection of the avalanche photodiode.
Embodiments of the utility model may be implemented as follows:
an embodiment of the present utility model provides a control apparatus including:
The heat conduction module comprises a heat transfer conductor and a refrigerating sheet, and the refrigerating sheet is arranged at the bottom of the heat transfer conductor;
The detector module is arranged on the heat transfer conductor and is in contact with the heat transfer conductor;
the heat dissipation base is arranged below the refrigerating sheet;
The temperature detection module is arranged on the heat transfer conductor and is used for outputting information representing the temperature of the heat transfer conductor;
the first heat insulation module is arranged on the installation side of the detector module on the heat transfer conductor.
Optionally, the heat-conducting heat-dissipating device further comprises at least two second heat-insulating modules, wherein the refrigerating sheet is arranged in the middle of the bottom of the heat-conducting conductor, and at least two second heat-insulating modules are arranged between the heat-conducting modules and the heat-dissipating base and are respectively positioned on two sides of the refrigerating sheet.
Optionally, the heat transfer conductor is provided with a containing cavity, the detector module is installed in the containing cavity, and the surface of the detector module is attached to the inner wall of the containing cavity.
Optionally, a heat conducting layer is arranged on the inner wall of the accommodating cavity.
Optionally, the detector module includes at least one avalanche photodiode, the number of avalanche photodiodes and the number of accommodation cavities being in one-to-one correspondence.
Optionally, the control device further includes a signal board, the signal board is disposed on a side of the first heat insulation module away from the heat conduction module, a pin of the avalanche photodiode is connected with the signal board, and the signal board is used for converting a current signal of the avalanche photodiode into a voltage signal.
Optionally, the control device further includes a chip protection shielding plate, and the chip protection shielding plate is disposed between the signal plate and the first heat insulation module.
Optionally, the voltage regulating module further comprises a voltage regulating circuit and a bias power supply, wherein the voltage regulating circuit and the bias power supply are connected, the bias power supply is connected with the signal board and the temperature detecting module, the signal board is used for transmitting the converted voltage signal of the avalanche photodiode to the bias power supply, the bias power supply is used for acquiring temperature information detected by the temperature detecting module and regulating working voltage according to the temperature information, and the voltage regulating circuit outputs the working voltage to the detector module.
Optionally, the detector comprises a detector control board and a TEC control board, wherein the detector control board and the TEC control board are arranged on one side, far away from the avalanche photodiode, of the signal board, and the TEC control board is connected with the heat conduction module.
The embodiment of the utility model also provides a flow cytometer, which comprises a shell and a control device, wherein the control device is arranged in the shell.
The control device and the flow cytometer of the embodiment of the utility model have the beneficial effects that:
The control device comprises a heat conduction module, a detector module, a heat dissipation base, a temperature detection module and a first heat insulation module, wherein the heat conduction module comprises a heat transfer conductor and a refrigerating sheet, the refrigerating sheet is arranged at the bottom of the heat transfer conductor, the detector module is arranged on the heat transfer conductor and is in contact with the heat transfer conductor, the heat dissipation base is arranged below the refrigerating sheet, the temperature detection module is arranged on the heat transfer conductor and is used for outputting information representing the temperature of the heat transfer conductor, and the first heat insulation module is arranged on the installation side of the heat transfer conductor. When the control device is used, the temperature detection module is used for outputting information representing the temperature of the heat transfer conductor, the first heat insulation module is arranged on the installation side of the heat transfer conductor of the detector module, so that the influence of the heat of the control module on the installation side of the detector module on the detector module and the heat transfer conductor is avoided, the temperature data detected by the temperature detection module are not accurate enough, and the heat dissipation base is arranged below the refrigerating sheet, so that the heat generated during the working of the refrigerating sheet is dissipated in real time. In conclusion, the control device can reduce the influence of the ambient temperature on the detector module and the heat transfer conductor, and improve the temperature control precision, so that the temperature detection accuracy of the detector module is ensured.
The flow cytometer includes a housing and a control device mounted in the housing. The flow cytometer has all the beneficial effects of the control device.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate some embodiments of the present utility model and therefore should not be considered as limiting the scope, and other related drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic structural diagram of a first view angle of a control device according to the present embodiment;
fig. 2 is a schematic structural diagram of a second view angle of the control device according to the present embodiment;
fig. 3 is a schematic structural diagram of a third view angle of the control device according to the present embodiment.
The icons are 10-heat conduction modules, 11-heat transfer conductors, 111-accommodating cavities, 12-refrigerating sheets, 13-TEC control boards, 20-temperature detection modules, 30-detector modules, 40-heat dissipation bases, 50-first heat insulation modules, 60-second heat insulation modules, 70-signal boards, 80-chip protection shielding boards, 90-detector control boards and 100-control devices.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present utility model more apparent, the technical solutions of the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model, and it is apparent that the described embodiments are some embodiments of the present utility model, but not all embodiments of the present utility model. The components of the embodiments of the present utility model generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the utility model, as presented in the figures, is not intended to limit the scope of the utility model, as claimed, but is merely representative of selected embodiments of the utility model. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
It should be noted that like reference numerals and letters refer to like items in the following figures, and thus once an item is defined in one figure, no further definition or explanation thereof is necessary in the following figures.
In the description of the present utility model, it should be noted that, if the terms "upper", "lower", "inner", "outer", and the like indicate an azimuth or a positional relationship based on the azimuth or the positional relationship shown in the drawings, or the azimuth or the positional relationship in which the inventive product is conventionally put in use, it is merely for convenience of describing the present utility model and simplifying the description, and it is not indicated or implied that the apparatus or element referred to must have a specific azimuth, be configured and operated in a specific azimuth, and thus it should not be construed as limiting the present utility model.
Furthermore, the terms "first," "second," and the like, if any, are used merely for distinguishing between descriptions and not for indicating or implying a relative importance.
It should be noted that the features of the embodiments of the present utility model may be combined with each other without conflict.
The flow cytometer is a high-tech biomedical detection instrument which can rapidly and accurately detect multiple physical and biological characteristics of single cells at the same time. Flow cytometers typically include an optical system, a fluid flow system, a detection and data processing system, and the like. The stability of the sensor APD (avalanche photodiode) of the photoelectric acquisition part of the flow cytometer is important for the stable operation of the flow cytometer.
The flow cytometer in the related art has the technical problems that the temperature stability of the avalanche photodiode is poor, and the detected temperature data is not accurate enough.
Referring to fig. 1-3, the present embodiment provides a flow cytometer including a housing and a control device 100, wherein the control device 100 is installed in the housing. The flow cytometer can effectively improve the technical problems, can improve the temperature stability of the avalanche photodiode, and improves the accuracy of temperature data detection of the avalanche photodiode.
The control device 100 comprises a heat conducting module 10, a detector module 30, a heat radiating base 40, a temperature detecting module 20 and a first heat insulation module 50, wherein the heat conducting module 10 comprises a heat transfer conductor 11 and a refrigerating sheet 12, the refrigerating sheet 12 is arranged at the bottom of the heat transfer conductor 11, the detector module 30 is arranged on the heat transfer conductor 11 and is in contact with the heat transfer conductor 11, the heat radiating base 40 is arranged below the refrigerating sheet 12, the heat generated by the refrigerating sheet 12 can be radiated in real time through the heat radiating base 40 when in refrigeration or heating work, so that rapid heat radiation is realized, the temperature detecting module 20 is arranged on the heat transfer conductor 11, the temperature detecting module 20 is used for outputting information representing the temperature of the heat transfer conductor 11, the first heat insulation module 50 is arranged on the installation side of the detector module 30, the detector module 30 can be installed on the installation side of the heat transfer conductor 11 through the first heat insulation module 50, meanwhile, the first heat insulation module 50 can avoid the influence of the heat of the control module on the detector module 30 and the heat transfer conductor 11 on the installation side of the detector module 30, and the detected temperature of the heat transfer conductor 11 can be ensured to be more accurate.
In this embodiment, the detector module 30 includes at least one avalanche photodiode. The temperature detection module 20 can monitor the actual temperature of the avalanche photodiode provided on the heat conduction module 10 in real time and radiate heat through the heat conduction module 10. In this embodiment, the number of avalanche photodiodes is six. In other embodiments, the number of avalanche photodiodes may be increased or decreased, and is not particularly limited herein. In this embodiment, the heat transfer conductor 11 has a long strip structure, and the temperature detection module 20 is disposed at an end of the heat transfer conductor 11. Wherein the temperature detection module 20 is disposed at a position where the end of the heat transfer conductor 11 is close to the top surface.
It will be appreciated that the heat transfer conductor 11 is provided with a receiving cavity 111, the detector module 30 is mounted within the receiving cavity 111, and the surface of the detector module 30 is in abutment with the inner wall of the receiving cavity 111.
In the present embodiment, the number of avalanche photodiodes and the number of accommodation cavities 111 are in one-to-one correspondence. The shape of the receiving cavity 111 and the shape of the avalanche photodiode are adapted, in particular circular structures.
Further, the inner wall of the accommodation chamber 111 is provided with a heat conductive layer, which is capable of conducting the temperature of the avalanche photodiode better. Specifically, the heat conductive layer may be a heat conductive glue. In other embodiments, the thermally conductive layer may also be a thermally conductive silicone grease.
In order to solve the technical problem that the heat transfer module 10 in the prior art easily generates heat back when radiating heat, in this embodiment, the heat transfer module 10 further includes at least two second heat insulation modules 60, the cooling fin 12 is disposed in the middle of the bottom of the heat transfer conductor 11, and the at least two second heat insulation modules 60 are disposed between the heat transfer module 10 and the heat dissipation base 40 and are disposed on two sides of the cooling fin 12 respectively, wherein the cooling fin 12 is connected with the heat transfer conductor 11 and the heat dissipation base 40 respectively through the second heat insulation modules 60. Specifically, the second heat insulation modules 60 are disposed on two sides of the bottom surface of the cooling fin 12, so that heat entering the lower heat dissipation base 40 or outside the side is blocked from being transmitted back to the cooling fin 12 again, the phenomenon of heat transmission in the heat dissipation process is avoided, and the overall heat dissipation effect is improved.
In this embodiment, the first and second insulation modules 50 and 60 are both alumina ceramics. In other embodiments, the first and second heat insulation modules 50 and 60 may also be glass heat insulation cotton, air heat insulation cotton, etc., without being particularly limited herein.
In the present embodiment, the number of the second heat insulating modules 60 is two. In other embodiments, the number of the second heat insulation modules 60 may be adjusted according to practical situations, which is not specifically limited herein.
It should be noted that, the control device 100 further includes a signal board 70 and a chip protection shielding board 80, the signal board 70 is disposed on a side of the first heat insulation module 50 far away from the heat conduction module 10, the pins of the avalanche photodiode are connected to the signal board 70, the signal board 70 is used for converting the current signal of the avalanche photodiode into a voltage signal, the chip protection shielding board 80 is disposed between the signal board 70 and the first heat insulation module 50, the chip protection shielding board 80 can facilitate the installation of the signal board 70 and the first heat insulation module 50, and meanwhile, the influence of external factors on the circuit signal of the signal board 70 can be avoided, and the first heat insulation module 50 can block the temperature of the signal board 70 from being transmitted to the heat transfer conductor 11.
It should be noted that the heat conduction module 10 further includes a TEC control board 13, the TEC control board 13 is disposed on a side of the signal board 70 away from the avalanche photodiode, the TEC control board 13 is connected to the cooling plate 12, and the cooling plate 12 performs temperature adjustment control through the TEC control board 13. The TEC control board 13 includes a driving control module and a temperature monitoring circuit, the temperature monitoring circuit is connected with the driving control module, the temperature monitoring circuit is connected with the heat transfer conductor 11, and is used for monitoring temperature information of the heat transfer conductor 11 in real time and feeding back the temperature information to the driving control module, and the driving control module controls the refrigerating sheet 12 to perform refrigeration or heating according to the difference between actual temperature information fed back by the temperature monitoring circuit and target control temperature information.
Further, the control module further includes a detector control board 90, the detector control board 90 is disposed on a side of the signal board 70 away from the avalanche photodiode, and the detector control board 90 is connected to the detector module 30, and the detector control board 90 is used for controlling and adjusting the detector module 30.
It should be noted that, the control device 100 further includes a voltage regulating module, the voltage regulating module includes a voltage regulating circuit and a bias power supply, the bias power supply is connected with the signal board 70 and the temperature detecting module 20, the signal board 70 is used for transmitting the voltage signal of the converted avalanche photodiode to the bias power supply, the bias power supply is used for obtaining the temperature information detected by the temperature detecting module 20, and adjusting the working voltage according to the temperature information, and the voltage regulating circuit outputs the working voltage to the detector module 30. Specifically, the voltage regulating module can obtain temperature information fed back by the temperature detecting module 20, and the voltage regulating module outputs an operating voltage to the avalanche photodiode according to a difference between the temperature information and the target temperature information, so as to compensate the avalanche photodiode and ensure the operating stability of the avalanche photodiode.
In this embodiment, the output end of the voltage regulating circuit is connected to the working pin of the avalanche photodiode.
Specifically, the bias power supply outputs a smaller working voltage to the voltage regulating circuit when the temperature information exceeds the target temperature information, the voltage regulating circuit outputs the smaller working voltage to the detector module 30, and the bias power supply outputs a larger working voltage to the voltage regulating circuit when the temperature information does not reach the target temperature information, and the voltage regulating circuit outputs the larger working voltage to the detector module 30.
Specifically, the drive control module controls the cooling fin 12 to cool when the actual temperature information exceeds the target control temperature information, and controls the cooling fin 12 to heat when the actual temperature information does not reach the target control temperature information.
In addition to this, the heat conduction module 10 further comprises a heat conduction member, and the top of the cooling fin 12 is provided with the heat conduction member, and optionally, the bottom of the cooling fin 12 is also provided with the heat conduction member. The heat conducting members are disposed at intermediate positions at the top and/or bottom of the cooling fin 12. Specifically, the heat conducting component is heat conducting silicone grease, and the heat conducting silicone grease is coated on the top surface and the bottom surface of the refrigerating sheet 12. Thereby ensuring that the heat of the heat transfer conductor 11 can be quickly dissipated through the heat dissipation base 40. Meanwhile, the heat-conducting silicone grease can also reduce the temperature difference between the top surface and the bottom surface of the refrigerating sheet 12, so that the working efficiency of the refrigerating sheet 12 is improved.
In other embodiments, the thermally conductive member may also be a thermally conductive glue. The heat conductive adhesive may be disposed on the top surface and other positions of the bottom surface of the cooling fin 12, which is not particularly limited herein.
The control device 100 and the flow cytometer provided in this embodiment have at least the following advantages:
The avalanche photodiode of the flow cytometer in the prior art can receive fluorescent signals with different wavelengths and amplify the fluorescent signals, and the amplified signals are received and processed by the acquisition card and uploaded to the upper computer for data analysis to finally generate a result. The operational stability of the avalanche photodiode is important for the overall stability of the flow cytometer. Among other factors, the stability of the avalanche photodiode includes reverse voltage and ambient temperature. It is therefore critical to ensure stability of the avalanche photodiode to ensure reverse voltage stability and temperature stability. When the control device 100 provided in this embodiment is used, the temperature detection module 20 is used for outputting information representing the temperature of the heat transfer conductor 11, and since the temperature stability of the detector module 30 is easily affected by the external temperature, the first heat insulation module 50 is disposed on the mounting side of the detector module 30 on the heat transfer conductor 11, and the detector module 30 is fixed in the heat transfer conductor 11 through the first heat insulation module 50, and the temperature of the detector module 30 can be prevented from being affected by the external influence, so that the avalanche photodiode temperature data detected by the temperature detection module 20 is not accurate enough, and the heat dissipation base 40 is disposed below the refrigerating sheet 12, so that heat generated during the operation of the refrigerating sheet 12 is dissipated in real time. The control device 100 can insulate the temperature of the detector module 30 from the external temperature by the first heat insulation module 50.
In summary, the embodiment of the utility model provides a control device 100 and a flow cytometer, wherein the control device 100 comprises a heat conduction module 10, a detector module 30, a heat dissipation base 40, a temperature detection module 20 and a first heat insulation module 50, the heat conduction module 10 comprises a heat transfer conductor 11 and a refrigerating sheet 12, the refrigerating sheet 12 is arranged at the bottom of the heat transfer conductor 11, the detector module 30 is arranged at the heat transfer conductor 11 and is in contact with the heat transfer conductor 11, the heat dissipation base 40 is arranged below the refrigerating sheet 12, the temperature detection module 20 is arranged at the heat transfer conductor 11 and is used for outputting information representing the temperature of the heat transfer conductor 11, and the first heat insulation module 50 is arranged at the mounting side of the detector module 30 at the heat transfer conductor 11. When the control device 100 is used, the temperature detection module 20 is used for outputting information representing the temperature of the heat transfer conductor 11, and the temperature of the detector module 30 is easily affected by the external temperature, so that the first heat insulation module 50 is arranged on the installation side of the heat transfer conductor 11 of the detector module 30, and therefore, the influence of the heat of the control module on the installation side of the detector module 30 on the detector module 30 and the heat transfer conductor 11 is avoided, the temperature data detected by the temperature detection module 20 are not accurate enough, and the heat dissipation base 40 is arranged below the refrigerating sheet 12, so that the heat generated during the working of the refrigerating sheet 12 is dissipated in real time. The control device 100 can block the heat of the control module on the installation side of the detector module 30 through the first heat insulation module 50 to affect the detector module 30 and the heat transfer conductor 11, and ensure the stability of the temperature of the detector module 30, thereby ensuring the accuracy of the temperature detection of the detector module 30.
The flow cytometer includes a housing and a control device 100, the control device 100 being mounted in the housing. The flow cytometer has all the advantages of the control device 100 described above.
The foregoing is merely illustrative of the present utility model, and the present utility model is not limited thereto, and any changes or substitutions easily contemplated by those skilled in the art within the scope of the present utility model should be included in the present utility model. Therefore, the protection scope of the present utility model shall be subject to the protection scope of the claims.
Claims (10)
1. A control apparatus, characterized by comprising:
The heat conduction module (10) comprises a heat transfer conductor (11) and a refrigerating sheet (12), wherein the refrigerating sheet (12) is arranged at the bottom of the heat transfer conductor (11);
A detector module (30) provided on the heat transfer conductor (11) and in contact with the heat transfer conductor (11);
A heat radiation base (40) arranged below the refrigerating sheet (12);
A temperature detection module (20) disposed on the heat transfer conductor (11), the temperature detection module (20) being configured to output information indicative of a temperature of the heat transfer conductor (11);
and a first heat insulation module (50) provided on the detector module (30) on the side where the heat transfer conductor (11) is mounted.
2. The control device according to claim 1, further comprising at least two second heat insulation modules (60), wherein the cooling fin (12) is disposed in the middle of the bottom of the heat transfer conductor (11), and wherein at least two second heat insulation modules (60) are disposed between the heat conduction module (10) and the heat dissipation base (40) and are located on both sides of the cooling fin (12), respectively.
3. The control device according to claim 1, characterized in that the heat transfer conductor (11) is provided with a receiving cavity (111), the detector module (30) is mounted in the receiving cavity (111), and the surface of the detector module (30) is in contact with the inner wall of the receiving cavity (111).
4. A control device according to claim 3, characterized in that the inner wall of the receiving chamber (111) is provided with a heat conducting layer.
5. A control arrangement according to claim 3, characterized in that the detector module (30) comprises at least one avalanche photodiode, the number of avalanche photodiodes being in one-to-one correspondence with the number of accommodation cavities (111).
6. The control device according to claim 5, characterized in that the control device (100) further comprises a signal plate (70), the signal plate (70) being arranged on the side of the first thermally insulating module (50) remote from the thermally conducting module (10), the pins of the avalanche photodiode being connected to the signal plate (70), the signal plate (70) being arranged to convert the current signal of the avalanche photodiode into a voltage signal.
7. The control device according to claim 6, characterized in that the control device (100) further comprises a chip protection shield plate (80), the chip protection shield plate (80) being arranged between the signal plate (70) and the first heat insulation module (50).
8. The control device according to claim 6, further comprising a voltage regulating module, wherein the voltage regulating module comprises a voltage regulating circuit and a bias power supply which are connected, the bias power supply is connected with the signal board (70) and the temperature detecting module (20), the signal board (70) is used for transmitting the converted voltage signal of the avalanche photodiode to the bias power supply, the bias power supply is used for acquiring temperature information detected by the temperature detecting module (20) and regulating an operating voltage according to the temperature information, and the voltage regulating circuit outputs the operating voltage to the detector module (30).
9. The control device of claim 8, further comprising a detector control board (90) and a TEC control board (13), wherein the detector control board (90) and the TEC control board (13) are both disposed on a side of the signal board (70) remote from the avalanche photodiode, and wherein the TEC control board (13) is connected to the thermal conduction module (10).
10. A flow cytometer comprising a housing and the control device of any of claims 1-9, the control device (100) being mounted within the housing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202421194760.6U CN222866498U (en) | 2024-05-28 | 2024-05-28 | A control device and flow cytometer |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202421194760.6U CN222866498U (en) | 2024-05-28 | 2024-05-28 | A control device and flow cytometer |
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| CN222866498U true CN222866498U (en) | 2025-05-13 |
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| CN202421194760.6U Active CN222866498U (en) | 2024-05-28 | 2024-05-28 | A control device and flow cytometer |
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