CN211652657U - POCT equipment for detecting blood physicochemical indexes based on capacitance method - Google Patents
POCT equipment for detecting blood physicochemical indexes based on capacitance method Download PDFInfo
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Abstract
The utility model relates to a biomedical sensor technical field discloses a POCT equipment based on electric capacity method detects blood physics and chemistry index. The equipment comprises a power supply system, an embedded control system, a microprocessor system, an excitation detection system and a sensor system for detecting the physical and chemical indexes of blood. The sensor of the sensor system comprises a micro-super-capacitance sensing chip and a sensing reaction pool which is used for bearing the blood to be detected and providing a physicochemical reaction area; the micro-super-capacitor sensing chip is arranged in the sensing reaction tank; the micro-super-capacitance sensing chip is provided with at least one group of capacitors formed by 2 electrodes close to each other, and the thickness and the parallel distance of the electrodes are respectively 0.01-1mm and 0.05-2 mm. When the physicochemical property of the blood added on the sensing chip is changed, the dielectric constant is changed, and the capacitance value of the micro-super capacitor is changed accordingly. By detecting the capacitance value, the change of the physicochemical property of the added blood can be reflected.
Description
Technical Field
The utility model relates to a biomedical check out test set's technical field, concretely relates to POCT equipment based on electric capacity method detects blood physicochemical index.
Background
Point Of Care test (poct), which means clinical test and bedside test performed near a patient, is a test method that performs analysis immediately at a sampling site and rapidly obtains a test result, and is characterized by providing clinical diagnosis basis for timely medical intervention.
Blood is an important component of human body, plays an important role in human body circulation and metabolism, and can assist in diagnosing the health condition of human body by detecting the physicochemical indexes of blood. Blood tests comprise a plurality of projects, relate to a plurality of physicochemical indexes, and take bleeding and blood coagulation indexes as examples, and blood coagulation instruments and thromboelastography instruments are mainly used at present.
Unlike the conventional method for detecting the quantity and activity of certain agglutinated components singly, the thromboelastogram can record the whole process from agglutination to fibrinolysis and can provide information about the blood coagulation function of a patient relatively comprehensively. The thromboelastogram is detected based on the change of viscoelasticity in the blood agglutination process, a curve is generated along with the increase and the decrease of the blood clot agglutination strength, and the whole blood agglutination and fibrinolysis can be reflected intuitively.
Is limited by the methodology principle of the thromboelastography instrument, and is not easy to form a portable POCT device.
Disclosure of Invention
In order to solve the deficiencies existing in the prior art, the utility model provides a POCT equipment based on electric capacity method detects blood physicochemical index.
The utility model discloses a realize through following technical scheme:
a POCT device for detecting blood physicochemical indexes based on a capacitance method comprises:
the blood physical and chemical index detection system comprises a power supply system, an embedded control system, a microprocessor system, an excitation detection system and a sensor system for detecting the physical and chemical indexes of blood; the micro-super-capacitor sensor in the sensor system comprises a micro-super-capacitor sensing chip and a sensing reaction tank, wherein the sensing reaction tank is used for bearing detected blood and providing a physicochemical reaction area;
the micro-super-capacitance sensing chip is provided with at least one group of capacitors formed by 2 electrodes which are close to each other, and the adjacent electrodes are arranged between the adjacent electrodesThe parallel spacing of (A) is 0.05-2 mm. The micro-super-capacitor sensing chip provided by the patent utilizes the characteristic that a micro-super-capacitor has a certain capacitance value. The capacitance is calculated as C ═ S/4 π kd. Wherein, the dielectric constant is the dielectric constant, S is the opposite area of the capacitor plate, d is the distance of the capacitor plate, and k is the constant of the electrostatic force. A volume of blood sample is introduced into the capacitors, the blood constituting the medium between the capacitors. When the physicochemical property of the blood added on the sensing chip is changed, the dielectric constant of the blood is changed, the capacitance value of the micro-super capacitor constructed by the sensing chip is changed, and the change of the physicochemical property of the added blood can be reflected by detecting the capacitance value of the micro-super capacitor constructed by the sensing chip. Blood is composed of plasma and blood cells, which mainly include three types, red blood cells, white blood cells and platelets. Plasma is an intercellular substance, and is a pale yellow translucent liquid, and contains a large amount of water, as well as inorganic salts, fibrinogen, albumin, globulin, enzymes, hormones, various nutrients, metabolites, and the like. The diameter of the red blood cells is 7-8.5 μm, and the red blood cells are in a double-concave disc shape. The platelets are disc-shaped, have diameters of 1-4 mu m to 7-8 mu m, and have large individual differences (5-12 mu m)3). The white blood cells are divided into two types of granulocytes and non-granulocytes, and the diameter of the white blood cells is 6-20 mu m. Various components in blood store human health information, and physiological changes or pathological changes of organisms often cause changes of blood components, so that the detection of the physicochemical properties of the blood has important clinical significance. Since blood constitutes the medium of the micro-supercapacitors, the various components of the medium (blood) must fall between the two plates of the capacitor. The heights of the adjacent electrodes are kept the same, and the parallel distances are consistent, so that the solution can be uniformly distributed, analysis and model construction are facilitated, and the influence of unequal distances on results is eliminated. Therefore, according to a large number of innovative experiments, the patent finally finds that the physical and chemical properties of the blood can be effectively detected when the distance between the adjacent electrodes is 0.05-2mm, and accurate and precise detection signals and detection results are obtained.
Further, the thickness of the electrode of the capacitor is 0.01-1 mm. The thickness of the electrode is related to the area of the electrode, and according to the analysis of blood characteristics and the requirements on the accuracy of detection results and the like, the fact that the physicochemical property of the blood can be effectively detected when the thickness of the electrode is 0.01-1mm is finally found, and accurate and precise detection signals and detection results are obtained.
Further, the micro ultra-capacitance sensing chip is provided with at least 3 groups of capacitors consisting of 2 electrodes close to each other. The beneficial effects of adopting a plurality of groups of micro-supercapacitors are as follows: 1. forming a micro-super-capacitor micro-array to improve the detection sensitivity; 2. a control group can be set to improve the accuracy; 3. the method can realize multi-element detection, namely can be applied to detection of a plurality of different projects; 4. high throughput testing can be achieved, i.e., multiple samples can be tested for the same item.
Further, different groups of capacitors form a parallel connection relationship, which is beneficial to reducing the wiring space and obtaining larger detection area.
Furthermore, the micro-super-capacitance sensing chip is provided with a lead wire connected with the electrode.
Furthermore, the micro-super-capacitor sensing chip is provided with a sensing area and a lead area. By providing the lead areas, various possibilities are provided for mounting and application of the chip, and the like, and the expansion is realized.
Furthermore, the micro-super-capacitor sensing chip is obtained by preparing an electrode on a conductive polyester material through a wet etching method or preparing an electrode on a conductive silicon or conductive glass substrate through a photoetching method.
Further, the micro-super-capacitor sensor for detecting the blood physical and chemical performance indexes comprises a micro-super-capacitor sensing chip and a sensing reaction pool, wherein the sensing reaction pool is used for bearing detected blood and providing a physical and chemical reaction area, and the micro-super-capacitor sensing chip is arranged in the sensing reaction pool.
Blood is introduced into the micro-super-capacitor sensor and enters the capacitor of the micro-super-capacitor sensor chip to form a medium of the micro-super-capacitor, and when the physical and chemical indexes of the blood change, the dielectric constant of the blood correspondingly changes, so that the capacitance of the micro-super-capacitor sensor changes. The change of the physical and chemical properties of blood can be reflected by detecting the change of the capacitance of the micro-super-capacitance sensor, so that the physiological change or the pathological change of an organism can be reflected, and the micro-super-capacitance sensor has important clinical significance.
For example, the process of changing Blood from a fluid state to a non-fluid jelly-like clot, i.e., Blood Coagulation (Blood Coagulation), converts fibrinogen in plasma to insoluble fibrin, interweaves the polymer fibrin into a mesh, and nets many Blood cells therein to form a clot. Through the change condition of this patent little super capacitance sensor ability detection capacity in whole blood coagulation process, form the change curve, can understand the time of blood coagulation, the change isoparametric of dielectric constant directly perceivedly to carry out analysis and comparison with the parameter in the sample database, obtain corresponding inspection result.
Further, the sensing reaction tank is a groove, one side of the sensing reaction tank is close to the bottom surface of the groove, a strip-shaped hole is designed in the bottom surface of the groove, and the micro-super-capacitor sensing chip is inserted into the groove through the strip-shaped hole.
Furthermore, the sensing reaction tank is a groove, the sensing reaction tank and the sensing area of the micro-supercapacitor sensing chip are positioned at the bottom of the groove, and the lead area is connected with an external circuit.
Further, the power supply system generates multiple power supplies for the power adapter through a series of DC/DC chips and the LDO voltage conversion chip.
Furthermore, the embedded control system is used for providing interaction of control instructions and data information between upper computer software and the microprocessor system.
The upper computer software is special application software developed based on a Linux operating system.
The embedded control system is used for realizing an LCD display function, an RTC real-time function, a USB peripheral function, an LIS serial port transmission function, a network port data transmission function, a storage function and a serial port upgrading and debugging function.
Furthermore, the microprocessor system is used for carrying out data interaction with the upper computer software, receiving an instruction sent by the upper computer software on one hand, and executing corresponding operation according to the received instruction; on the other hand, feeding back data information to the upper computer; the microprocessor system is used for controlling the starting and stopping of the excitation detection system on one hand and receiving an output signal of the excitation detection system on the other hand; the microprocessor system comprises a temperature control module for controlling the sensor system; the microprocessor system is used for realizing the functions of storage, serial port or JTAG upgrading and debugging and the like.
Further, the excitation detection system comprises an excitation module and a signal processing module; the excitation module is used for generating resonance excitation of the electrochemical micro super capacitor; the signal processing module is used for processing and outputting the resonance signal generated by the excitation module.
Further, the sensor system comprises a temperature control module for controlling an ambient temperature of the sensor system.
Compared with the prior art, the utility model discloses following beneficial effect has:
the POCT equipment for detecting the blood physicochemical indexes based on the capacitance method utilizes the characteristic that a micro-super capacitor in a micro-super capacitor sensing chip has a certain capacitance value. A volume of blood sample is introduced into the capacitors, the blood constituting the medium between the capacitors. When the physicochemical property of the blood added on the sensing chip is changed, the dielectric constant of the blood is changed, the capacitance value of the micro-super capacitor constructed by the sensing chip is changed, the change of the physicochemical property of the added blood can be reflected by detecting the capacitance value of the micro-super capacitor constructed by the sensing chip, the physiological change or the pathological change of an organism can be further analyzed, and the method has important clinical significance.
Drawings
FIG. 1 is a schematic circuit diagram of a micro-supercapacitor sensor chip;
FIG. 2 is a schematic circuit diagram of a micro-supercapacitor sensor chip;
FIG. 3 is a schematic diagram of a sensing reaction cell structure of a micro-supercapacitor sensor;
FIG. 4 is a schematic structural diagram of a micro-supercapacitor sensor;
FIG. 5 is a schematic structural diagram of the POCT apparatus;
fig. 6 is a flow chart of the POCT apparatus.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the invention. The raw materials used in the examples and application examples are all commercially available.
Example 1
As shown in fig. 1 to 6, a POCT apparatus for detecting physical and chemical indexes of blood based on a capacitance method includes:
the blood physical and chemical index detection system comprises a power supply system, an embedded control system, a microprocessor system, an excitation detection system and a sensor system for blood physical and chemical index detection. The micro-super-capacitor sensor in the sensor system comprises a micro-super-capacitor sensing chip and a sensing reaction tank, wherein the sensing reaction tank is used for bearing detected blood and providing a physical and chemical reaction area, and the micro-super-capacitor sensing chip is arranged in the sensing reaction tank.
The micro-super-capacitance sensing chip for detecting the physical and chemical performance indexes of blood is provided with three groups of capacitors consisting of 2 electrodes (11,12) which are close to each other, and the parallel distance between the adjacent electrodes (11,12) is 0.05 mm.
The electrodes (11,12) of the capacitor are 0.5mm thick.
The capacitors of different groups form a parallel connection relationship, which is beneficial to reducing the wiring space and obtaining larger detection area.
The micro ultra-capacitor sensing chip is provided with a lead 13 connected with the capacitor. The micro-super capacitor sensing chip is provided with a sensing area 1 and a lead area 2. By providing the lead pads 2, a plurality of possibilities are provided for mounting and application of the chip, etc., with expandability.
The sensing area 1 of the sensing chip is mainly used for generating electric signals. The lead pads 2 of the sensor chip are mainly used for the conduction of electrical signals.
The micro-super-capacitor sensing chip is obtained by preparing a metal film electrode layer on a conductive polyester material through a wet etching method or preparing the metal film electrode layer on a conductive silicon or conductive glass substrate through a photoetching method. The micro-super-capacitor sensing chip utilizes the characteristic that the micro-super-capacitor has a certain capacitance value. A volume of blood sample is introduced into the capacitors, the blood constituting the medium between the capacitors. When the physicochemical property of the added blood on the sensing chip is changed, the dielectric constant of the blood is changed, the capacitance value of the micro-super capacitor constructed by the sensing chip is changed, and the change of the physicochemical property of the added blood can be reflected by detecting the capacitance value of the micro-super capacitor constructed by the sensing chip.
Since blood constitutes the medium of the micro-supercapacitors, the various components of the medium (blood) must fall between the two plates of the capacitor. Because the thickness of the electrode is related to the area of the formed electrode, through analysis of blood characteristics and requirements on accuracy of detection results and the like, according to a large number of innovative experiments, the invention finally discovers that the physicochemical property of blood can be effectively detected when the distance between adjacent electrodes is 0.05-2mm and the thickness of the electrode is 0.01-1mm, and accurate and precise detection signals and detection results are obtained.
As shown in fig. 3 to 4, the micro ultra-capacitor sensor for detecting the physical and chemical performance indexes of blood comprises a micro ultra-capacitor sensor chip 3 and a sensing reaction tank 4 for bearing the blood to be detected and providing a physical and chemical reaction area, wherein the micro ultra-capacitor sensor chip 3 is disposed in the sensing reaction tank 4.
Blood is introduced into the micro-super-capacitor sensor, enters the capacitor of the sensing chip 3 to form a medium of the micro-super-capacitor, and the change of the physicochemical property of the blood can be reflected by detecting the change of the capacitance of the micro-super-capacitor sensor, so that the physiological change or the pathological change of an organism can be further analyzed, and the micro-super-capacitor sensor has important clinical significance.
The sensing reaction tank 4 is a groove, a strip-shaped hole 41 is designed at one side of the sensing reaction tank 4 and close to the bottom surface of the groove, and the micro-super-capacitor sensing chip 3 is inserted into the groove through the strip-shaped hole. The width of the strip-shaped hole is slightly larger than that of the micro-super-capacitor sensing chip; the height of the strip-shaped hole is slightly larger than the thickness of the micro-super-capacitor sensing chip.
The micro-ultra-capacitor sensor chip is inserted into the groove such that the sensor area 1 and a very small portion of the lead area 2 are located in the groove.
The sensing reaction tank 4 and the sensing area 1 of the micro-ultra-capacitor sensing chip 3 are positioned at the bottom of the groove, and the lead area 2 is connected with an external circuit.
The sensor reaction chamber 4 is made of an insulating material that does not react with blood components, and has a columnar shape.
The sensing reaction tank 4 is provided with an upper cover for ensuring the sealing property of the physical and chemical reaction environment.
The micro-super-capacitor sensing chip can be designed into any shape according to application requirements, and the material of the micro-super-capacitor sensing chip has insulation property and does not react with blood components.
The power supply system generates a plurality of paths of power supplies for the power adapter through a series of DC/DC chips and the LDO voltage conversion chip.
The embedded control system is used for providing interaction of control instructions and data information between upper computer software and the microprocessor system.
The upper computer software is special application software developed based on a Linux operating system. The embedded control system is used for realizing an LCD display function, an RTC real-time function, a USB peripheral function, an LIS serial port transmission function, a network port data transmission function, a storage function and a serial port upgrading and debugging function.
The microprocessor system is used for carrying out data interaction with the upper computer software, receiving an instruction sent by the upper computer software on one hand, and executing corresponding operation according to the received instruction; and on the other hand, feeding back data information to the upper computer.
The microprocessor system is used for controlling the starting and stopping of the excitation detection system on one hand and receiving an output signal of the excitation detection system on the other hand;
the microprocessor system is used for controlling a temperature control module of the sensor system;
the microprocessor system is used for realizing a storage function and a serial port or JTAG upgrading and debugging function;
the excitation detection system comprises an excitation module and a signal processing module.
The excitation module is used for generating resonance excitation of the electrochemical micro super capacitor.
The signal processing module is used for processing and outputting the resonance signal generated by the excitation module.
The sensor system includes a temperature control module for controlling an ambient temperature of the sensor system.
A use method of POCT equipment for detecting blood physicochemical indexes based on a capacitance method comprises the following steps:
s1, starting a power supply system, and starting an embedded control system and a microprocessor system;
s2, starting a temperature control module of the sensor system to enable the sensor module to be in a set temperature environment;
s3, starting an excitation detection system and starting a measurement function of a microprocessor;
s4, adding blood into a sensor reaction tank;
s5, the micro-processing system uploads the obtained measurement data to the embedded control system;
and S6, analyzing and processing the acquired data by the embedded control system, and calculating to obtain blood coagulation detection related index results and the like.
Application example 1
The POCT equipment for detecting the physical and chemical indexes of blood based on a capacitance method is used, the equipment is started before sample adding, a proper blood sample is added into the sensing reaction pool 4, and the upper cover is immediately covered.
During blood coagulation, fibrinogen is converted to insoluble fibrin, and polymer fibrin is interlaced into a network, which contains many blood cells that form a blood clot. Through the change condition of this patent's little super capacitor sensor detection electric capacity in whole blood coagulation process, form the change curve, can understand the time of blood coagulation, the change isoparametric of dielectric constant directly perceived to carry out the analysis and comparison with the parameter in the sample database, obtain corresponding testing result.
TABLE 1 analysis of the test results of the various micro-supercapacitive sensor chips
As can be seen from Table 1, in examples 1 to 3 and comparative examples 1 to 2, when the electrode thickness is constant, the distance between adjacent electrodes is less than 0.05mm, the signal is weak and the sensitivity is poor; when the thickness is more than or equal to 0.05mm and less than 2mm, the signal is strong and the sensitivity is high; when the particle size is larger than 2mm, the signal intensity and sensitivity are greatly reduced.
As can be seen from comparative example 3, when the distance between adjacent electrodes was constant, the signal intensity and sensitivity obtained when the electrode thickness was 1.3mm were lower than those obtained when the electrode thickness was 0.5 mm.
While the foregoing description shows and describes the preferred embodiments of the present invention, it is to be understood that the invention is not limited to the forms disclosed herein, but is not intended to be exhaustive or to exclude other embodiments and may be used in various other combinations, modifications, and environments and is capable of changes within the scope of the inventive concept as expressed herein, commensurate with the above teachings, or the skill or knowledge of the relevant art. But that modifications and variations may be effected by those skilled in the art without departing from the spirit and scope of the invention, which is to be limited only by the claims appended hereto.
Claims (10)
1. A POCT device for detecting blood physicochemical indexes based on a capacitance method is characterized by comprising a power supply system, an embedded control system, a microprocessor system, an excitation detection system and a sensor system for detecting the blood physicochemical indexes; the micro-super-capacitor sensor in the sensor system comprises a micro-super-capacitor sensing chip and a sensing reaction tank, wherein the sensing reaction tank is used for bearing detected blood and providing a physicochemical reaction area;
the micro-super-capacitance sensing chip is provided with at least one group of capacitors formed by 2 electrodes close to each other, and the parallel distance between the adjacent electrodes is 0.05-2 mm.
2. POCT equipment for detecting physical and chemical indicators of blood based on capacitance method as claimed in claim 1, wherein the thickness of the electrodes of the capacitor is 0.01-1 mm.
3. The POCT device for detecting the physical and chemical indexes of blood based on the capacitance method as claimed in claim 1, wherein different groups of capacitors form a parallel connection relationship.
4. The POCT equipment for detecting the physical and chemical indexes of blood based on the capacitance method as claimed in claim 1, wherein the micro-super-capacitance sensing chip is provided with a lead wire connected with an electrode.
5. The POCT device for detecting the physical and chemical indexes of blood based on the capacitance method as claimed in claim 4, wherein the micro-super-capacitor sensing chip is provided with a sensing area and a lead area.
6. The POCT device for detecting physical and chemical indexes of blood based on the capacitance method as recited in claim 1, wherein the sensing reaction tank is a groove, a strip-shaped hole is designed at a position close to the bottom surface of the groove at one side of the sensing reaction tank, and the micro-ultra-capacitance sensing chip is inserted into the groove through the strip-shaped hole.
7. The POCT device for detecting physical and chemical indexes of blood based on the capacitance method as claimed in claim 1, wherein the embedded control system is used for providing a host computer software to interact with the microprocessor system for control instructions and data information.
8. The POCT equipment for detecting the physical and chemical indexes of blood based on the capacitance method as claimed in claim 7, wherein a microprocessor system is used for carrying out data interaction with the upper computer software, receiving an instruction sent by the upper computer software on one hand, and executing corresponding operation according to the received instruction; on the other hand, feeding back data information to the upper computer;
the microprocessor system comprises a temperature control module for controlling the starting and stopping of the excitation detection system, receiving the output signal of the excitation detection system, controlling the sensor system, and realizing a storage function and a serial port or JTAG upgrading and debugging function.
9. The POCT equipment for detecting the physical and chemical indexes of blood based on the capacitance method as claimed in claim 1, wherein the excitation detection system comprises an excitation module and a signal processing module; the excitation module is used for generating resonance excitation of the electrochemical micro super capacitor; the signal processing module is used for processing and outputting the resonance signal generated by the excitation module.
10. POCT equipment for detecting physical and chemical indicators of blood based on capacitance method as claimed in claim 1, wherein the sensor system comprises a temperature control module for controlling the ambient temperature of the sensor system.
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| CN114563448A (en) * | 2022-02-15 | 2022-05-31 | 深圳市爱康生物科技股份有限公司 | Blood quality detection device and method |
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| CN114563448A (en) * | 2022-02-15 | 2022-05-31 | 深圳市爱康生物科技股份有限公司 | Blood quality detection device and method |
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