CN201200499Y - 网格状的金属骨科植入体 - Google Patents
网格状的金属骨科植入体 Download PDFInfo
- Publication number
- CN201200499Y CN201200499Y CN 200820114426 CN200820114426U CN201200499Y CN 201200499 Y CN201200499 Y CN 201200499Y CN 200820114426 CN200820114426 CN 200820114426 CN 200820114426 U CN200820114426 U CN 200820114426U CN 201200499 Y CN201200499 Y CN 201200499Y
- Authority
- CN
- China
- Prior art keywords
- metal
- implant
- dimensional mesh
- orthopedic implant
- orthopaedics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000007943 implant Substances 0.000 title claims abstract description 63
- 239000002184 metal Substances 0.000 title claims abstract description 54
- 230000000399 orthopedic effect Effects 0.000 title abstract description 36
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 5
- 239000010410 layer Substances 0.000 claims description 5
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 5
- 239000002356 single layer Substances 0.000 claims description 5
- 239000011247 coating layer Substances 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 abstract description 13
- 210000002449 bone cell Anatomy 0.000 abstract description 4
- 208000020084 Bone disease Diseases 0.000 abstract description 2
- 238000010586 diagram Methods 0.000 description 9
- 230000007547 defect Effects 0.000 description 4
- 239000007769 metal material Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000004927 fusion Effects 0.000 description 3
- 239000002344 surface layer Substances 0.000 description 2
- 206010061728 Bone lesion Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 239000003462 bioceramic Substances 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004070 electrodeposition Methods 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000007750 plasma spraying Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
Landscapes
- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
本实用新型公开了一种网格状的金属骨科植入体，该植入体表层具有三维网孔，三维网孔包括数个自植入体表面向里的孔和连通部分或全部孔的横向孔道。病人患骨病植入该网格状的金属骨科植入体后，骨细胞会嵌合长入三维网孔的孔及孔道中并且环绕闭锁，达到长久地有效地防止植入体和骨质脱离松动效果。
Description
技术领域
本实用新型涉及一种网格状的金属骨科植入体。
背景技术
人骨在患有肿瘤、退行性病变或是创伤、先天畸形等情况时，经常需要使用板状或柱状骨科植入体对骨病变缺损部位进行融合、填充、连接、支撑或替代。用于骨科植入体的材料有很多，例如自体骨、同种异体骨、生物陶瓷、硅胶和金属材料等等，其中由金属材料制作的各种骨科植入体使用得最为广泛，但是毕竟骨骼与金属表面贴合的界面无法产生生物学结合，随着时间的推移骨质与金属材料脱离松动的趋势会逐渐显露，给植入体的稳定带来隐患。
实用新型内容
本实用新型的目的是提供一种防止远期松动的金属骨科植入体。
为实现上述目的，本实用新型采取以下设计方案：
一种网格状的金属骨科植入体，其特征在于，该植入体表层具有三维网孔，所述三维网孔包括数个自植入体表面向里的孔和连通部分或全部所述孔的横向孔道。
该植入体为板块状或柱状。
所述三维网孔布置于所述金属骨科植入体的通体结构。
所述三维网孔布置于所述金属骨科植入体的局部结构，其余部分结构为致密金属体。
所述横向孔道为单层孔道或多层孔道。
它采用医用金属制成。
所述三维网孔的表面具有羟基磷灰石涂层。
本实用新型的优点是：
1、本实用新型网格状的金属骨科植入体，该植入体表层具有三维网孔，三维网孔包括数个自植入体表面向里的孔和连通部分或全部孔的横向孔道。病人患骨病植入该网格状的金属骨科植入体后，骨细胞会嵌合长入三维网孔的孔及孔道中并且环绕闭锁，达到长久地有效地防止植入体和骨质脱离松动效果。
2、本实用新型网格状的金属骨科植入体，三维网孔布置于金属骨科植入体的局部结构，其余部分结构为致密金属体。致密金属体是根据患者骨质损坏的差异和生物力学的需要而在适当部位如植入体的芯部或棱边部位或其它部位以承担较大力学载荷例如抗拉、抗压、抗弯、抗扭功能。
3、本实用新型网格状的金属骨科植入体，其中横向孔道为多层孔道，如果考虑到为了承受较大力学载荷而需要将致密金属体体积设计得尺寸较大时，附着在致密金属体表面的网格状孔道也可以采用单层。
4、本实用新型网格状的金属骨科植入体，其中三维网孔的表面具有羟基磷灰石涂层，具有诱导骨细胞长入的功能。
附图说明
图1为本实用新型网格状的金属骨科植入体实施例一立体结构示意图(三维网体布置于植入体的通体结构)
图2为本实用新型网格状的金属骨科植入体实施例二立体结构示意图(沿轴线部位设置承担力学载荷的致密金属体)
图3为本实用新型网格状的金属骨科植入体实施例三立体结构示意图(外表面适当部位设置承担力学载荷的致密金属体)
图4为本实用新型网格状的金属骨科植入体使用实施例示意图(用于脊柱椎体的支撑融合)
图5为本实用新型网格状的金属骨科植入体使用实施例示意图(用于下颌骨缺损部位的替代和填充)
图6为本实用新型网格状的金属骨科植入体使用实施例示意图(用于骨连接)
图7为本实用新型网格状的金属骨科植入体使用实施例示意图(用于骨质填充)
图8为本实用新型中的三维网体结构一示意图(三维网体横向具有单层孔道)
图9为本实用新型中的三维网体结构二示意图(三维网体横向具有多层孔道)
具体实施方式
如图1、图2、图3所示，本实用新型网格状的金属骨科植入体1，其特征在于，该植入体表层具有三维网孔，三维网孔包括数个自植入体表面向里的孔2和连通部分或全部孔2的横向孔道3。
该植入体1为板块状(如图3所示)或柱状(如图1、图2所示)或其它形状。
三维网孔布置于金属骨科植入体1的通体结构(如图1所示)。
三维网孔布置于金属骨科植入体1的局部结构，其余部分结构为致密金属体4(如图2、图3所示)。
横向孔道3为单层孔道(如图8所示)或多层孔道(如图9所示)。
三维网孔的表面具有羟基磷灰石涂层，该羟基磷灰石涂层可采用常规的等离子喷涂法或电化学沉集法形成。
横向孔道3可以是平行布置或交叉布置或成网状布置。
本实用新型网格状的金属骨科植入体的加工制作方法是：根据手术需要的大小和形状在电子计算机中建立网格状的金属骨科植入体实体模型，然后采用激光或高能电子束加工方法熔融成型，还可以用电火花加工、化学腐蚀等方法在已经铸造或锻造成型的金属骨科植入体毛坯表面刻蚀、腐蚀出所需要的网孔，此外也可以用粉末烧结方法得到所需的网孔结构。本实用新型网格状的金属骨科植入体使用具有良好生物相容性的医用金属材料制造。
考虑到骨细胞嵌合长入的需要，三维网孔的孔径尺寸通常控制在0.05～8mm之间。
本实用新型网格状的金属骨科植入体的用途举例：融合、填充、连接、支撑或替代。如图4所示，网格状的金属骨科植入体1成块状或柱状，用于脊柱椎间起支撑作用，随着骨组织往植入体1中的长入而最终将相邻椎体融合。如图5所示，网格状的金属骨科植入体1成板块状，用于下颌骨缺损部位的替代。如图6所示，网格状的金属骨科植入体1成柱状，用于管状骨骨折后的连接。如图7所示，网格状的金属骨科植入体1成块状，用于骨缺损部位的填充。
Claims (7)
1、一种网格状的金属骨科植入体，其特征在于，该植入体表层具有三维网孔，所述三维网孔包括数个自植入体表面向里的孔和连通部分或全部所述孔的横向孔道。
2、根据权利要求1所述的网格状的金属骨科植入体，其特征在于，该植入体为板块状或柱状。
3、根据权利要求1所述的网格状的金属骨科植入体，其特征在于，所述三维网孔布置于所述金属骨科植入体的通体结构。
4、根据权利要求1所述的网格状的金属骨科植入体，其特征在于，所述三维网孔布置于所述金属骨科植入体的局部结构，其余部分结构为致密金属体。
5、根据权利要求1或2或3或4所述的网格状的金属骨科植入体，其特征在于，所述横向孔道为单层孔道或多层孔道。
6、根据权利要求1或2或3或4所述的网格状的金属骨科植入体，其特征在于，它采用医用金属制成。
7、根据权利要求1或2或3或4所述的网格状的金属骨科植入体，其特征在于，所述三维网孔的表面具有羟基磷灰石涂层。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200820114426 CN201200499Y (zh) | 2008-05-19 | 2008-05-19 | 网格状的金属骨科植入体 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200820114426 CN201200499Y (zh) | 2008-05-19 | 2008-05-19 | 网格状的金属骨科植入体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201200499Y true CN201200499Y (zh) | 2009-03-04 |
Family
ID=40422811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200820114426 Expired - Fee Related CN201200499Y (zh) | 2008-05-19 | 2008-05-19 | 网格状的金属骨科植入体 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201200499Y (zh) |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102113924A (zh) * | 2009-12-31 | 2011-07-06 | 北京爱康宜诚医疗器材股份有限公司 | 髋臼骨缺损填充体 |
| CN102512267A (zh) * | 2011-12-07 | 2012-06-27 | 上海交通大学 | 一种复合多孔结构骨修复体及其制备方法 |
| CN104780870A (zh) * | 2012-09-25 | 2015-07-15 | 4网络公司 | 可编程植入物和使用可编程植入物修复骨结构的方法 |
| CN104887333A (zh) * | 2015-05-05 | 2015-09-09 | 张辉 | 钛基立体网状构架人工骨种植体 |
| US9636226B2 (en) | 2013-03-15 | 2017-05-02 | 4Web, Inc. | Traumatic bone fracture repair systems and methods |
| CN107468382A (zh) * | 2017-08-23 | 2017-12-15 | 北京爱康宜诚医疗器材有限公司 | 足踝关节融合器 |
| CN108125735A (zh) * | 2017-12-25 | 2018-06-08 | 北京爱康宜诚医疗器材有限公司 | 股骨柄假体 |
| US9999516B2 (en) | 2008-12-18 | 2018-06-19 | 4Web, Inc. | Implant device having a non-planar surface |
| EP3181097A4 (en) * | 2014-08-13 | 2018-07-18 | Fujian Institute Of Research On The Structure Of Matter, Chinese Academy Of Sciences | Low-modulus medical implantation porous support structure |
| CN108888389A (zh) * | 2018-09-14 | 2018-11-27 | 北京爱康宜诚医疗器材有限公司 | 关节面融合器 |
| CN110037832A (zh) * | 2019-04-16 | 2019-07-23 | 华南协同创新研究院 | 一种骨修复用复合单元结构多孔支架及加工方法 |
| US10517737B2 (en) | 2015-05-22 | 2019-12-31 | Stryker European Operations Limited | Joint or segmental bone implant for deformity correction |
| CN111134907A (zh) * | 2020-01-08 | 2020-05-12 | 武汉优联百康医疗科技有限公司 | 一种新型胫骨假体锁定柄及其制备方法 |
| IT202000014881A1 (it) * | 2020-06-22 | 2021-12-22 | Mt Ortho S R L | Granulo cilindrico in materiale metallico biocompatibile per vertebroplastica |
| WO2022099491A1 (zh) * | 2020-11-11 | 2022-05-19 | 北京积水潭医院 | 一种用于松质骨重建假体 |
| US12102535B2 (en) | 2019-11-15 | 2024-10-01 | 4Web, Llc | Piezoelectric coated implants and methods of using piezoelectric coated implants to repair bone structures |
| US12115071B2 (en) | 2012-09-25 | 2024-10-15 | 4Web, Llc | Programmable intramedullary implants and methods of using programmable intramedullary implants to repair bone structures |
| US12201531B2 (en) | 2020-07-08 | 2025-01-21 | 4Web, Llc | Implants having bone growth promoting agents contained within biodegradable materials |
| US12279964B2 (en) | 2008-12-18 | 2025-04-22 | 4Web, Llc | Implants having bone growth promoting agents and methods of using such implants to repair bone structures |
-
2008
- 2008-05-19 CN CN 200820114426 patent/CN201200499Y/zh not_active Expired - Fee Related
Cited By (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12263094B2 (en) | 2008-12-18 | 2025-04-01 | 4Web, Llc | Implant having a shaft coated with a web structure |
| US11278421B2 (en) | 2008-12-18 | 2022-03-22 | 4Web, Inc. | Implant device having curved or arced struts |
| US11510787B2 (en) | 2008-12-18 | 2022-11-29 | 4-Web Spine, Inc. | Implant having a shaft coated with a web structure |
| US9999516B2 (en) | 2008-12-18 | 2018-06-19 | 4Web, Inc. | Implant device having a non-planar surface |
| US12279964B2 (en) | 2008-12-18 | 2025-04-22 | 4Web, Llc | Implants having bone growth promoting agents and methods of using such implants to repair bone structures |
| CN102113924A (zh) * | 2009-12-31 | 2011-07-06 | 北京爱康宜诚医疗器材股份有限公司 | 髋臼骨缺损填充体 |
| CN102512267A (zh) * | 2011-12-07 | 2012-06-27 | 上海交通大学 | 一种复合多孔结构骨修复体及其制备方法 |
| US12115071B2 (en) | 2012-09-25 | 2024-10-15 | 4Web, Llc | Programmable intramedullary implants and methods of using programmable intramedullary implants to repair bone structures |
| US9987137B2 (en) | 2012-09-25 | 2018-06-05 | 4Web, Inc. | Programmable implant having curved or arced struts |
| CN104780870B (zh) * | 2012-09-25 | 2018-03-02 | 4网络公司 | 可编程植入物和使用可编程植入物修复骨结构的方法 |
| US9757235B2 (en) | 2012-09-25 | 2017-09-12 | 4Web, Inc. | Spinal programmable implant |
| US10849756B2 (en) | 2012-09-25 | 2020-12-01 | 4Web Medical | Programmable implant |
| CN104780870A (zh) * | 2012-09-25 | 2015-07-15 | 4网络公司 | 可编程植入物和使用可编程植入物修复骨结构的方法 |
| US9636226B2 (en) | 2013-03-15 | 2017-05-02 | 4Web, Inc. | Traumatic bone fracture repair systems and methods |
| EP3181097A4 (en) * | 2014-08-13 | 2018-07-18 | Fujian Institute Of Research On The Structure Of Matter, Chinese Academy Of Sciences | Low-modulus medical implantation porous support structure |
| CN104887333A (zh) * | 2015-05-05 | 2015-09-09 | 张辉 | 钛基立体网状构架人工骨种植体 |
| US10517737B2 (en) | 2015-05-22 | 2019-12-31 | Stryker European Operations Limited | Joint or segmental bone implant for deformity correction |
| US11395747B2 (en) | 2015-05-22 | 2022-07-26 | Stryker European Operations Limited | Joint or segmental bone implant for deformity correction |
| US11759332B2 (en) | 2015-05-22 | 2023-09-19 | Stryker European Operations Limited | Joint or segmental bone implant for deformity correction |
| CN107468382A (zh) * | 2017-08-23 | 2017-12-15 | 北京爱康宜诚医疗器材有限公司 | 足踝关节融合器 |
| CN108125735A (zh) * | 2017-12-25 | 2018-06-08 | 北京爱康宜诚医疗器材有限公司 | 股骨柄假体 |
| CN108888389A (zh) * | 2018-09-14 | 2018-11-27 | 北京爱康宜诚医疗器材有限公司 | 关节面融合器 |
| CN110037832A (zh) * | 2019-04-16 | 2019-07-23 | 华南协同创新研究院 | 一种骨修复用复合单元结构多孔支架及加工方法 |
| CN110037832B (zh) * | 2019-04-16 | 2021-06-01 | 华南协同创新研究院 | 一种骨修复用复合单元结构多孔支架及加工方法 |
| US12102535B2 (en) | 2019-11-15 | 2024-10-01 | 4Web, Llc | Piezoelectric coated implants and methods of using piezoelectric coated implants to repair bone structures |
| CN111134907A (zh) * | 2020-01-08 | 2020-05-12 | 武汉优联百康医疗科技有限公司 | 一种新型胫骨假体锁定柄及其制备方法 |
| WO2021260474A1 (en) * | 2020-06-22 | 2021-12-30 | Mt Ortho S.R.L. | Cylindrical granule made of biocompatible metal material for vertebroplasty |
| IT202000014881A1 (it) * | 2020-06-22 | 2021-12-22 | Mt Ortho S R L | Granulo cilindrico in materiale metallico biocompatibile per vertebroplastica |
| US12201531B2 (en) | 2020-07-08 | 2025-01-21 | 4Web, Llc | Implants having bone growth promoting agents contained within biodegradable materials |
| WO2022099491A1 (zh) * | 2020-11-11 | 2022-05-19 | 北京积水潭医院 | 一种用于松质骨重建假体 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN201200499Y (zh) | 网格状的金属骨科植入体 | |
| Han et al. | Porous tantalum and titanium in orthopedics: a review | |
| CN201164513Y (zh) | 人工髋关节股骨柄 | |
| CN104780870B (zh) | 可编程植入物和使用可编程植入物修复骨结构的方法 | |
| Yadroitsava et al. | Bone regeneration on implants of titanium alloys produced by laser powder bed fusion: A review | |
| EP3685866B1 (en) | Structural porous biomaterial and implant formed of same | |
| US20210186708A1 (en) | Intervertebral cage with porosity gradient | |
| CN201164511Y (zh) | 人工髋关节髋臼外衬 | |
| CN109872769B (zh) | 一种孔隙率梯度变化的植入体的制备方法 | |
| US20080288083A1 (en) | Osseointegration Implant | |
| CN104887351A (zh) | 一种高强度小孔径金属骨小梁及其制备方法 | |
| CN114748214B (zh) | 一种骨植入用负泊松比三维复合结构单胞及骨固定植入物 | |
| WO2012010327A4 (en) | Surgical implant | |
| EP2727559B1 (en) | Spinous metal particle | |
| EP4353479A3 (en) | Porous implant structures | |
| CN201558197U (zh) | 髋臼骨缺损填充体 | |
| CN106344221A (zh) | 类骨多孔生物力学仿生设计脊柱融合器及制备方法和用途 | |
| CN102846408B (zh) | 植骨填充金属颗粒体 | |
| CN204636623U (zh) | 3d金属骨小梁椎间融合器 | |
| Wang et al. | Preparation, modification, and clinical application of porous tantalum scaffolds | |
| CN105380731A (zh) | 一种多孔钽金属骨连接器及其应用 | |
| Baroutaji et al. | Metallic meta-biomaterial as biomedical implants | |
| CN101708134A (zh) | 低弹性模量人工髋关节股骨柄 | |
| CN115635081B (zh) | 一种3d打印梯度多孔结构种植体及其制备方法 | |
| CN113017939A (zh) | 椎间融合器及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090304 Termination date: 20120519 |