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CN201135436Y - Needle-like neural microelectrodes with position-stabilizing structures - Google Patents

Needle-like neural microelectrodes with position-stabilizing structures Download PDF

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CN201135436Y
CN201135436Y CNU2007201907558U CN200720190755U CN201135436Y CN 201135436 Y CN201135436 Y CN 201135436Y CN U2007201907558 U CNU2007201907558 U CN U2007201907558U CN 200720190755 U CN200720190755 U CN 200720190755U CN 201135436 Y CN201135436 Y CN 201135436Y
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electrode body
electrode
needle
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裴为华
陈弘达
朱琳
张旭
郭凯
王淑静
陈海峰
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Abstract

一种带位置稳定结构的针状神经微电极,其特征在于,包括:一电极体,该电极体为针状,有一前端及一尾端,在该电极体靠近尾端的一侧的外壁上沿相同截面处固定有多个凸起;多个电极点,多个电极点涂布于电极体的表面,该每一电极体均用涂布于电极体表面的传导线接至电极体的尾端;一绝缘层,该绝缘层涂布于电极体的表面并覆盖于传导线;所述多个电极点露出于绝缘层。本实用新型的带位置稳定结构的针状神经微电极,在针状的神经微电极体的侧面增加了可以使电极定位的结构。该结构不增加制作工艺的难度,不影响植入,但可以减小植入式针状电极与植入组织之间的相对位移,特别是可以防止电极脱出。

Figure 200720190755

A needle-shaped nerve microelectrode with a position-stabilizing structure is characterized in that it includes: an electrode body, which is needle-shaped, has a front end and a tail end, and is edged on the outer wall of the side of the electrode body near the tail end. Multiple protrusions are fixed at the same section; multiple electrode points are coated on the surface of the electrode body, and each electrode body is connected to the tail end of the electrode body with a conductive wire coated on the surface of the electrode body ; an insulating layer, which is coated on the surface of the electrode body and covers the conductive wire; the plurality of electrode points are exposed on the insulating layer. In the needle-shaped nerve microelectrode with a position-stabilizing structure of the utility model, a structure capable of positioning the electrode is added to the side of the needle-shaped nerve micro-electrode body. The structure does not increase the difficulty of the manufacturing process and does not affect the implantation, but can reduce the relative displacement between the implanted needle-shaped electrode and the implanted tissue, and in particular can prevent the electrode from falling out.

Figure 200720190755

Description

带位置稳定结构的针状神经微电极 Needle-like neural microelectrodes with position-stabilizing structures

技术领域 technical field

本实用新型属于生理信号检测的电极传感器及加工技术领域,更具体是指带位置稳定结构的针状神经微电极。The utility model belongs to the technical field of electrode sensors and processing for physiological signal detection, and more specifically refers to a needle-shaped nerve microelectrode with a position-stabilizing structure.

背景技术 Background technique

脑电或神经电信号的获取是了解神经电活动情况的主要方法之一,是神经电生理、医疗诊断或脑科学的重要研究手段。细胞外电极是一种在细胞外附近记录神经元电势变化或利用刺激电流影响细胞电活动的器件;用于记录的称为记录电极,用于刺激的称为刺激电极。The acquisition of EEG or neural electrical signals is one of the main methods to understand the electrical activity of nerves, and is an important research method for neuroelectrophysiology, medical diagnosis or brain science. An extracellular electrode is a device that records changes in the potential of neurons near the outside of the cell or uses a stimulating current to affect the electrical activity of the cell; the one used for recording is called a recording electrode, and the one used for stimulation is called a stimulating electrode.

这种电极一般有两种,一种是非侵入式的,电极多呈平面,另一种是侵入式的,呈针状,记录或刺激点位于针尖附近,可以记录到单个神经元的电活动信号或对有限范围内的神经元进行刺激。在动物实验中,当这种针状电极插入神经组织中时,如果没有辅助的定位或固定装置,电极在神经组织中的位置会随着植入体的运动而改变,特别容易发生的是植入电极沿与插入方向相反的位移,导致电极上记录/刺激位点与被记录/刺激神经单元之间位置的不确定性,从而使记录和刺激得效果难以保持稳定,影响了记录信号的质量或一致性。严重时会造成植入电极的脱出。There are generally two types of such electrodes, one is non-invasive, and the electrodes are mostly flat, and the other is invasive, needle-shaped, and the recording or stimulation point is located near the needle tip, which can record the electrical activity signal of a single neuron Or stimulate a limited range of neurons. In animal experiments, when the needle-shaped electrode is inserted into the nerve tissue, if there is no auxiliary positioning or fixation device, the position of the electrode in the nerve tissue will change with the movement of the implant. The displacement of the input electrode along the direction opposite to the insertion direction leads to uncertainty in the position between the recording/stimulation site on the electrode and the recorded/stimulated neural unit, which makes it difficult to maintain stable recording and stimulation effects and affects the quality of the recorded signal or consistency. In severe cases, the implanted electrodes will come out.

实用新型内容Utility model content

本实用新型的目的在于,提供一种带位置稳定结构的针状神经微电极,在针状的神经微电极体的侧面增加了可以使电极定位的结构。该结构改变了原本平直的针状电极体侧面结构,使电极体的横截面在电极轴向上有一处或多处凸起,该结构不增加制作工艺的难度,不影响植入,但可以减小植入式针状电极与植入组织之间的相对位移,特别是可以防止电极脱出。The purpose of the utility model is to provide a needle-shaped nerve microelectrode with a position-stabilizing structure, and a structure for positioning the electrode is added to the side of the needle-shaped nerve microelectrode body. This structure changes the side structure of the originally straight needle-shaped electrode body, so that the cross section of the electrode body has one or more protrusions in the electrode axis. This structure does not increase the difficulty of the manufacturing process and does not affect the implantation, but it can Reduce the relative displacement between the implanted needle electrode and the implanted tissue, especially to prevent the electrode from coming out.

本实用新型提供一种带位置稳定结构的针状神经微电极,其特征在于,包括:The utility model provides a needle-shaped nerve microelectrode with a position-stabilizing structure, which is characterized in that it comprises:

一电极体,该电极体为针状,有一前端及一尾端,在该电极体靠近尾端的一侧的外壁上沿相同截面处固定有多个凸起;An electrode body, the electrode body is needle-shaped, has a front end and a tail end, and a plurality of protrusions are fixed along the same section on the outer wall of the electrode body near the tail end;

多个电极点,该多个电极点涂布于电极体的表面,该每一电极体均用涂布于电极体表面的传导线接至电极体的尾端;A plurality of electrode points, the plurality of electrode points are coated on the surface of the electrode body, and each electrode body is connected to the tail end of the electrode body with a conductive wire coated on the surface of the electrode body;

一绝缘层,该绝缘层涂布于电极体的表面并覆盖于传导线;an insulating layer, which is coated on the surface of the electrode body and covers the conductive wire;

所述多个电极点露出于绝缘层。The plurality of electrode points are exposed on the insulating layer.

其中该电极体为硅或金属或玻璃材料。Wherein the electrode body is silicon or metal or glass material.

其中该电极体的横截面形状是圆形、椭圆或多边形的形状。Wherein the cross-sectional shape of the electrode body is circular, elliptical or polygonal.

其中该电极体上的多个凸起的数量为1-4个。Wherein the number of protrusions on the electrode body is 1-4.

其中该电极体和多个凸起是一体成型。Wherein the electrode body and the protrusions are integrally formed.

其中该电极体和多个凸起是焊接或粘接。Wherein the electrode body and the protrusions are welded or bonded.

其中该多个凸起为翼状三角形,该三角形指向前端的夹角为锐角。Wherein the plurality of protrusions are wing-shaped triangles, and the included angle of the triangles pointing to the front end is an acute angle.

其中该多个凸起为翼形片状,该翼形片状指向前端的夹角为锐角。Wherein the plurality of protrusions are in the shape of airfoils, and the included angle of the airfoils pointing to the front end is an acute angle.

其中多个电极点的数量为1-50个。The number of multiple electrode points is 1-50.

本实用新型的有益效果是:The beneficial effects of the utility model are:

本实用新型的带位置稳定结构的针状神经微电极,在针状的神经微电极体的侧面增加了可以使电极定位的结构。该结构改变了原本平直的针状电极体侧面结构,使电极体的横截面在电极轴向上有一处或多处凸起,该结构不增加制作工艺的难度,不影响植入,但可以减小植入式针状电极与植入组织之间的相对位移,特别是可以防止电极脱出。In the needle-shaped nerve microelectrode with a position-stabilizing structure of the utility model, a structure capable of positioning the electrode is added to the side of the needle-shaped nerve microelectrode body. This structure changes the side structure of the originally straight needle-shaped electrode body, so that the cross section of the electrode body has one or more protrusions in the electrode axis. This structure does not increase the difficulty of the manufacturing process and does not affect the implantation, but it can Reduce the relative displacement between the implanted needle electrode and the implanted tissue, especially to prevent the electrode from coming out.

附图说明 Description of drawings

为进一步说明本实用新型的技术内容,以下结合实施例及附图详细说明如后,其中:In order to further illustrate the technical content of the present utility model, below in conjunction with embodiment and accompanying drawing, describe in detail as follows, wherein:

图1是本实用新型的第一实施例的结构示意图;Fig. 1 is the structural representation of the first embodiment of the utility model;

图2是本实用新型的第二实施例的结构示意图。Fig. 2 is a schematic structural view of the second embodiment of the present invention.

具体实施方式 Detailed ways

请参阅图1所示,图1是本实用新型的第一实施例的结构示意图,本实用新型提供一种带位置稳定结构的针状神经微电极,其特征在于,包括:See also shown in Fig. 1, Fig. 1 is the structural representation of the first embodiment of the present utility model, the utility model provides a kind of needle-shaped nerve microelectrode with position stable structure, it is characterized in that, comprises:

一电极体1,该电极体1为针状,长度在0.5毫米到15毫米之间。有一前端2及一尾端3,电极体1的前端2呈锥形或凿形或刃形,可以以较小的阻力插入生物组织并最大程度减小对插入部位的损伤。该电极体1为硅或金属或玻璃材料,该电极体1的横截面形状是圆形、椭圆或多边形的形状,横截面面积一般在20平方微米到3个平方毫米。多个电极点4,该多个电极点4涂布于电极体1的表面,该每一电极体1均用涂布于电极体1表面的传导线5接至电极体1的尾端3,用于细胞外记录或刺激的电极点4的数量为1-50个(图中为一个),分布在电极体1前端或整个电极体1上,电极点4的表面积在10平方微米到5个平方毫米,每个电极点4上都通过传导线5接至电极体1的尾端3,这些传导线5相互绝缘隔离。电极体1上除电极点4外,其余部分,包括传导线5都被绝缘层7密封覆盖。当电极体1被植入动物神经组织时,电极点4的电位将随着其附近神经细胞电活动的电位变化而改变,并将这种电位变化通过传导线5传导到体外;或者将刺激电信号通过传导线5传递给电极点4,从而刺激或影响电极点4附近的神经的电活动。在该电极体1靠近尾端3的外壁上沿相同截面处固定有多个凸起6,该电极体1上的多个凸起4的数量为1-4个,该电极体1和多个凸起6是一体成型,或该电极体1和多个凸起6是焊接或粘接,该多个凸起6为翼状三角形,该三角形指向电极体1前端2的夹角为锐角。An electrode body 1, the electrode body 1 is needle-shaped, and the length is between 0.5 mm and 15 mm. There is a front end 2 and a tail end 3. The front end 2 of the electrode body 1 is conical or chisel-shaped or blade-shaped, which can be inserted into biological tissue with less resistance and minimize the damage to the insertion site. The electrode body 1 is made of silicon or metal or glass material. The cross-sectional shape of the electrode body 1 is circular, elliptical or polygonal, and the cross-sectional area is generally 20 square micrometers to 3 square millimeters. A plurality of electrode points 4, the plurality of electrode points 4 are coated on the surface of the electrode body 1, and each electrode body 1 is connected to the tail end 3 of the electrode body 1 with a conductive wire 5 coated on the surface of the electrode body 1, The number of electrode points 4 used for extracellular recording or stimulation is 1-50 (one in the figure), distributed on the front end of the electrode body 1 or the entire electrode body 1, and the surface area of the electrode points 4 ranges from 10 square microns to 5 Each electrode point 4 is connected to the tail end 3 of the electrode body 1 through a conductive wire 5, and these conductive wires 5 are insulated from each other. Except for the electrode point 4 , the rest of the electrode body 1 , including the conductive wire 5 , is sealed and covered by the insulating layer 7 . When the electrode body 1 is implanted in the animal nerve tissue, the potential of the electrode point 4 will change with the potential change of the electrical activity of the nearby nerve cells, and this potential change will be conducted to the outside of the body through the conductive wire 5; The signal is transmitted to the electrode point 4 through the conductive wire 5, thereby stimulating or affecting the electrical activity of the nerve near the electrode point 4. On the outer wall of the electrode body 1 close to the tail end 3, a plurality of protrusions 6 are fixed along the same section, the number of the plurality of protrusions 4 on the electrode body 1 is 1-4, and the electrode body 1 and the plurality of The protrusions 6 are integrally formed, or the electrode body 1 and the plurality of protrusions 6 are welded or bonded, the plurality of protrusions 6 are wing-shaped triangles, and the included angle of the triangles pointing to the front end 2 of the electrode body 1 is an acute angle.

请参阅图2所示,图2是本实用新型的第二实施例的结构示意图,该第二实施例与第一实施例的结构基本相同,相同的部位采用相同的标号,不同之处在于,在该电极体1靠近尾端的一侧的外壁上沿相同截面处固定有多个凸起6’,该多个凸起6’为翼形片状,该翼形片状指向电极体1前端2的夹角为锐角。See also shown in Fig. 2, Fig. 2 is the structural representation of the second embodiment of the present utility model, and the structure of this second embodiment is basically the same as that of the first embodiment, and the same position adopts the same label, and the difference is that A plurality of protrusions 6' are fixed along the same section on the outer wall of the electrode body 1 near the tail end, and the plurality of protrusions 6' are in the shape of wing-shaped pieces, which point to the front end 2 of the electrode body 1 The included angle is an acute angle.

结合参阅图1及图2,当电极体1插入生物组织时,特别是当带有凸起6、6’的电极体1的尾端3进入组织时,电极体1的尾端3的凸起6、6’朝前的一端由于角度较锐,形成的阻力较小,可以容易地进入;电极体1的尾端3凸起6、6’朝后的一端角度较大,形成的阻力较大,使得电极体1难以脱出。对于电极体1在沿与电极体1垂直方向上的横向移动,电极体1尾端3的凸起6、6’增加了电极体1前端2在组织内横向移动的阻力,因此也可以起到一定的限制作用。同时,由于凸起6、6’安装在电极体1尾端3,距位于电极体1前端2的电极点4尚有一定的距离,因此不会增加电极点4附近的插入损伤。这样,电极体1尾端3的多个凸起6、6’可以增加电极点4与刺激或记录对象之间的位置稳定关系,减小因电极体1移动而造成的信号噪声。Referring to Fig. 1 and Fig. 2, when the electrode body 1 is inserted into the biological tissue, especially when the tail end 3 of the electrode body 1 with protrusions 6, 6' enters the tissue, the protrusion of the tail end 3 of the electrode body 1 6. The front end of 6, 6' has a sharper angle, which forms less resistance and can be easily entered; the tail end 3 of the electrode body 1 protrudes 6, 6', and the rear end has a larger angle, forming greater resistance , making it difficult for the electrode body 1 to come out. For the lateral movement of the electrode body 1 in the direction perpendicular to the electrode body 1, the protrusions 6, 6' at the tail end 3 of the electrode body 1 increase the resistance of the front end 2 of the electrode body 1 to move laterally in the tissue, so it can also play a role Certain restrictions. At the same time, since the protrusions 6, 6' are installed at the tail end 3 of the electrode body 1, there is still a certain distance from the electrode point 4 located at the front end 2 of the electrode body 1, so the insertion damage near the electrode point 4 will not be increased. In this way, the plurality of protrusions 6, 6' on the tail end 3 of the electrode body 1 can increase the positional stability relationship between the electrode point 4 and the stimulation or recording object, and reduce the signal noise caused by the movement of the electrode body 1.

上述实施例仅是为了方便说明而举例而已,本实用新型所主张的权利范围自应以权利要求范围所述为准,而非仅限于上述实施例。The above-mentioned embodiments are only examples for convenience of description, and the scope of rights claimed by the utility model should be determined by the scope of the claims, rather than being limited to the above-mentioned embodiments.

Claims (9)

1、一种带位置稳定结构的针状神经微电极,其特征在于,包括:1. A needle-like neural microelectrode with a position-stabilizing structure, characterized in that it comprises: 一电极体,该电极体为针状,有一前端及一尾端,在该电极体靠近尾端的一侧的外壁上沿相同截面处固定有多个凸起;An electrode body, the electrode body is needle-shaped, has a front end and a tail end, and a plurality of protrusions are fixed along the same section on the outer wall of the electrode body near the tail end; 多个电极点,该多个电极点涂布于电极体的表面,该每一电极体均用涂布于电极体表面的传导线接至电极体的尾端;A plurality of electrode points, the plurality of electrode points are coated on the surface of the electrode body, and each electrode body is connected to the tail end of the electrode body with a conductive wire coated on the surface of the electrode body; 一绝缘层,该绝缘层涂布于电极体的表面并覆盖于传导线;an insulating layer, which is coated on the surface of the electrode body and covers the conductive wire; 所述多个电极点露出于绝缘层。The plurality of electrode points are exposed on the insulating layer. 2、如权利要求1所述的带位置稳定结构的针状神经微电极,其特征在于,其中该电极体为硅或金属或玻璃材料。2. The needle-shaped neural microelectrode with position stabilizing structure according to claim 1, wherein the electrode body is made of silicon or metal or glass material. 3、如权利要求1所述的带位置稳定结构的针状神经微电极,其特征在于,其中该电极体的横截面形状是圆形、椭圆或多边形的形状。3. The needle-shaped neural microelectrode with position stabilizing structure according to claim 1, wherein the cross-sectional shape of the electrode body is circular, elliptical or polygonal. 4、如权利要求1所述的带位置稳定结构的针状神经微电极,其特征在于,其中该电极体上的多个凸起的数量为1-4个。4. The needle-shaped neural microelectrode with a position stabilizing structure according to claim 1, wherein the number of protrusions on the electrode body is 1-4. 5、如权利要求1或4所述的带位置稳定结构的针状神经微电极,其特征在于,其中该电极体和多个凸起是一体成型。5. The needle-shaped nerve microelectrode with a position stabilizing structure according to claim 1 or 4, wherein the electrode body and the plurality of protrusions are integrally formed. 6、如权利要求1或4所述的带位置稳定结构的针状神经微电极,其特征在于,其中该电极体和多个凸起是焊接或粘接。6. The needle-shaped neural microelectrode with a position stabilizing structure according to claim 1 or 4, wherein the electrode body and the protrusions are welded or bonded. 7、如权利要求1或4所述的带位置稳定结构的针状神经微电极,其特征在于,其中该多个凸起为翼状三角形,该三角形指向前端的夹角为锐角。7. The needle-shaped neural microelectrode with a position stabilizing structure according to claim 1 or 4, wherein the plurality of protrusions are wing-shaped triangles, and the included angle of the triangles pointing to the front end is an acute angle. 8、如权利要求1或4所述的带位置稳定结构的针状神经微电极,其特征在于,其中该多个凸起为翼形片状,该翼形片状指向前端的夹角为锐角。8. The needle-shaped neural microelectrode with a position-stabilizing structure as claimed in claim 1 or 4, wherein the plurality of protrusions are in the shape of wing-shaped pieces, and the included angle between the wing-shaped pieces and the front end is an acute angle . 9、如权利要求1所述的带位置稳定结构的针状神经微电极,其特征在于,其中多个电极点的数量为1-50个。9. The needle-shaped neural microelectrode with a position-stabilizing structure according to claim 1, wherein the number of the plurality of electrode points is 1-50.
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CN102512151A (en) * 2011-12-09 2012-06-27 中国科学院半导体研究所 Method for manufacturing three-dimensional nervus microelectrode
WO2013131261A1 (en) * 2012-03-08 2013-09-12 中国科学院深圳先进技术研究院 Flexible intracranial cortex microelectrode chip, preparation and packaging method therefor, and packaging structure thereof
CN103445790A (en) * 2013-09-09 2013-12-18 重庆西南医院 Animal auditory detecting electrode positioning device
CN105559778A (en) * 2016-02-02 2016-05-11 上海交通大学 Brain electrode for collecting brain electrical signals for long time and preparation method thereof
CN105662390A (en) * 2008-06-20 2016-06-15 国武孝人 Electrode
CN108042129A (en) * 2017-12-29 2018-05-18 广东省中医院 A kind of three-dimensional tiny array electrode for being used to detect cardiac muscular tissue's electric signal
WO2022266953A1 (en) * 2021-06-24 2022-12-29 邢楚枫 Microelectrode array and manufacturing method therefor

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105662390A (en) * 2008-06-20 2016-06-15 国武孝人 Electrode
CN102512151A (en) * 2011-12-09 2012-06-27 中国科学院半导体研究所 Method for manufacturing three-dimensional nervus microelectrode
WO2013131261A1 (en) * 2012-03-08 2013-09-12 中国科学院深圳先进技术研究院 Flexible intracranial cortex microelectrode chip, preparation and packaging method therefor, and packaging structure thereof
CN103445790A (en) * 2013-09-09 2013-12-18 重庆西南医院 Animal auditory detecting electrode positioning device
CN105559778A (en) * 2016-02-02 2016-05-11 上海交通大学 Brain electrode for collecting brain electrical signals for long time and preparation method thereof
CN108042129A (en) * 2017-12-29 2018-05-18 广东省中医院 A kind of three-dimensional tiny array electrode for being used to detect cardiac muscular tissue's electric signal
WO2022266953A1 (en) * 2021-06-24 2022-12-29 邢楚枫 Microelectrode array and manufacturing method therefor

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