CN204038196U

CN204038196U - A kind of packaging of freeze-drying excipient preparation and delivery system

Info

Publication number: CN204038196U
Application number: CN201320544498.9U
Authority: CN
Inventors: 李和伟
Original assignee: Individual
Current assignee: Beijing Weibo Haitai Biotechnology Co ltd
Priority date: 2013-09-04
Filing date: 2013-09-04
Publication date: 2014-12-24
Anticipated expiration: 2023-09-04

Abstract

The utility model relates to a kind of packaging and delivery system of freeze-drying excipient preparation, comprise freeze-drying excipient preparation, solvent and packaging and send packaging and the delivery apparatus of described freeze-drying excipient preparation and solvent, it is characterized in that in described packaging and delivery apparatus, comprising a two-chamber mixing device, wherein solvent and freeze-drying excipient preparation are stored in the different cavitys of the two-chamber batch mixing cavity (9) in two-chamber mixing device respectively, solvent and freeze-drying excipient preparation is made can immediately to mix and derive in use by the interaction of each parts of two-chamber mixing device, described two-chamber mixing device comprises thrust unit (1) and two-chamber batch mixing cavity (9), described thrust unit (1) is by promotion cabin (12), accommodation chamber (15) and push-rod piston device (7, 8, 11) form.

Description

A kind of packaging of freeze-drying excipient preparation and delivery system

Technical field

The utility model relates to a kind of packaging and delivery system of freeze-drying excipient preparation, particularly a kind of freeze-drying excipient preparation being applied to food, health food, oral drug, topical drug and cosmetics, the two-chamber mixing device of itself and solvent are preserved respectively in same packaging, joining when using and delivery system, and its corresponding preparation method.

background technology

Freeze-drying excipient preparation is a kind of dosage form utilizing freeze-drying excipient technology to prepare, and it forms through cryodesiccated technological process is shaping by be filled into by preparation supplementary material in forming mould again.Because such preparation adopts freeze drying process; thermally sensitive composition can be protected not to be destroyed; preparation itself has a large amount of micropore and duct simultaneously; make it can very fast disintegration and dissolving, be therefore widely applied in medicine, food, health food and the cosmetic fields such as oral disnitegration tablet, fast-release tablet, chewable tablets, special cosmetics.

Technological process due to freeze-drying excipient preparation produces the characteristic in a large amount of micropore and duct, makes freeze-drying excipient preparation all have not high, the easy friability of formulation strengths and the very easily defect such as moisture absorption.Therefore the packing device selected by preparation that prepared by freeze-drying excipient technology is mostly two aluminium packaging, moisture barrier, barrier etc. to ensure it.But two aluminium packaging often itself does not have good supportive, need the protectiveness of auxiliary package enhancing to preparation by other with certain degree of hardness; It is all comparatively loaded down with trivial details when opening and use, and the experience sense used for its product brings certain influence.And two aluminium packaging needs to open its packaging in use, can use after mixing with its solvent, in mixed process, open packaging, mixing and by mixed liquor derive process more complicated, and be easily mixed into bacterium etc. cause packaging open after secondary pollution.

Traditional pre-fill type dual chamber syringe is mainly used in injecting use, pollute with other for avoiding the germ in production and use procedure, in hundred grades of clean areas, complete packaging process after must completing original position freeze-drying in syringe, substantially increase productive costs; Simultaneously; be main freeze drying protectant system based on Small molecular carbohydrate, sugar alcohol and amino acid due to traditional lyophilisation; its freeze-dried powder form is very responsive to physical mechanical power; if do not use original position freeze-drying; be very easy to broken; cause the inaccurate of dosage, freeze-dried powder fragment that is broken or that come off also can bring very large problem to the assembling of pre-fill type dual chamber syringe and use simultaneously.

Therefore, contriver dedicates itself to innovation, in order to solve packaging and the occupation mode of freeze-drying excipient preparation, simultaneously in order to open up packaging and the occupation mode of non-injection formula lyophilized formulations, a large amount of deep research and experimental work are carried out, provide that a kind of non-injection uses, namely can join in use namely to separate in same packaging with its solvent with, freeze-drying excipient preparation and preserve, directly mix the preparation of the packaging of the freeze-drying excipient preparation of derivation and delivery system and corresponding freeze-drying excipient preparation thereof, assembly method during use, this completes the utility model.

summary of the invention

The packaging of a kind of freeze-drying excipient preparation provided by the utility model and delivery system, comprise freeze-drying excipient preparation, solvent and packaging and send the device of described freeze-drying excipient preparation and solvent.The packaging of described freeze-drying excipient preparation and delivery apparatus, it is characterized in that in described packaging and delivery apparatus, comprising a two-chamber mixing device, preferred described packaging and delivery apparatus are a two-chamber mixing device, wherein solvent and freeze-drying excipient preparation are stored in the different cavitys of the two-chamber batch mixing cavity in two-chamber mixing device respectively, make solvent and freeze-drying excipient preparation can immediately mix and derive in use by the interaction of each parts of two-chamber mixing device.Two-chamber batch mixing cavity and other parts of preserving solvent and freeze-drying excipient preparation are separable so that change.

The freeze-drying excipient preparation used in the packaging of freeze-drying excipient preparation provided by the utility model and delivery system, it is primarily of functional component and adhesive agent composition, and adhesive agent: functional component=1:10 to 10:1.

Described adhesive agent is edible, can does used for cosmetic or pharmaceutically useful a kind of water-soluble high-molecular material, can be polysaccharide, polypeptide, protein, also may be synthetic polymeric's Polymer, or through the natural macromolecular material of modification or its compound.Conventional adhesive agent includes but not limited to, gelatin class (gelatin, gelatin hydrolysate etc.), cellulose ethers (carboxymethyl cellulose, HEMC etc.), modified starch series (pulullan, hydroxypropul starch etc.), PVP, PVA, hyalomitome acids, albumin, shitosan and different molecular weight product thereof or their combination etc.

Described functional component can be water-soluble also can be water-fast material, can be chemicals, bio-pharmaceutical, Chinese medical extract, vitamin, mineral matter, cosmetic beneficiating ingredient and other is to one or more in the useful active component of human body; The composite of one or more compositions following can be selected from:

Chemicals (active constituents of medicine):

Antipyretic-antalgic anti-inflammatory agent, such as aspirin, Diflunisal, salsalate, paracetamol, Indomethacin, brufen, naproxen, Ketoprofen, pirprofen, suprofen, Flurbiprofen, piroxicam, Meloxicam, aulin, Benzbromarone etc.;

Central stimulant, such as pemoline, adrafinil, Piracetam etc.;

Treatment migraine agent, such as Sumatriptan succinate;

Antalgesic, such as rotundin, buprenorphine, pentazocine, naloxone etc.;

Anti-parkinson and treatment senile dementia medicine, such as levodopa, compound carbidopa, compound benserazide, amantadine hydrochloride, piribedil, general sieve phenol amine, donepezil, huperzine are first-class;

Psychotolytic, such as chlorpromazine, fenazil, pethidine, thioridazine, Chlorprothixene, Clozapine, Sulpiride, Tai Bili, penfluridol, Risperidone etc.;

Antiepileptic and anticonvulsive drug, such as dilantin sodium, carbamazepine, Primidone, Gabapentin, Lamotrigine, sodium vedproate, Clonazepam etc.Hypnotic sedative agent, such as diazepam, nitrazepam, Oxazepam, Lorazepam, phenobarbital etc.;

Cholinesterase inhibitor, such as hyoscine etc.;

Antiarrhymic, such as the third pyridine, tocainide, mexiletine, aetmozine, dilantin sodium, Propafenone, amiodarone etc.;

Antianginal and antiatherosclerotic, such as Propranolol, nifedipine, Gemfibrozil, Bezafibrate, Lovastatin, Simvastatin, Pravastatin etc.;

Antihypertensive, such as Enalapril, captopril, Hydrochioro, Amlodipine etc.;

Adrenoceptor blocking agents, such as acebutolol, alprenolol etc.;

Corticosteroid medicine, such as betamethasone, cortisone acetate etc.;

Antidiabetic, such as Repaglinide etc.;

Antithyroid drug, such as propylthiouracil (PTU), Carbimazole, methimazole etc.;

Antithistamine, such as Cetirizine Hydrochloride, Loratadine etc.;

Autacoid, such as dinoprostone, Alprostadil, Betahistine etc.;

Digestive system surgical procedures, such as scopolamine butylbromide, Granisetron Hydrochloride etc.;

Hematological system medicine, such as EPO, cobamamide etc.;

Urinary system medicine, such as azosemide, frusemide etc.;

Reproductive system medicine, such as estrogen, Nandrolone Phenylpropionate etc.;

Antiparasitic agent, such as albendazole, cambendazole etc.;

Antineoplastic, such as aminoglutethimide, amsacrine etc.;

Antimicrobial, such as ampicillin, sulbenicillin disodium etc.;

Tri-Biocin, such as Amoxicillin, cefalexin, Cefprozil, CEFUROXIME AXETIL, Roxithromycin, Erythromycin Ethylsuccinate, josamycin etc.;

Traditional Chinese medicine ingredients:

Effective Component of Chinese Medicine monomer, as: Breviscapinun, qinghaosu etc.;

Single medicinal material material extract and compound Chinese medicine extract, as: tanshinone extract, salvianolic acid extract, composite salvia dropping extract of bolus, cow-bezoar bolus compound extract, ginseng stem and leave general saponin, asiatic moonseed extract, general ginsenoside, Breviscapinun, notoginseng triol-saponin, Glabrous Sarcandra Herb medicinal extract, arasaponin, capillary extract, extractum rhei, andrographolide, hawthorne leaf P.E, asiaticoside etc.;

Natural plant extracts: as aloe extract, yam extract, Bilberry fruit P.E, Bitter Melon P.E, green-tea extract, fucoidin, glabridin, Paeoniflorin etc.;

Bioactive ingredients: EGF, bFGF, aFGF, KGF, IGF, PDGF, VEGF, placenta hydrolyzate, milk extract etc.

Cosmetic beneficiating ingredient: collagen, hyaluronic acid, sodium alginate, aloe extract, general ginsenoside, arasaponin, Chinese rhubarb extract, bamboo lotus water Bulbus Lilii extract, peony extract, EGF, bFGF, aFGF, KGF, IGF, PDGF, VEGF, placenta hydrolyzate, milk extract, various surfactants, algae extract, various vitamin, various beneficial mineral matter, SOD, metallothionein, other raw materials see " international cosmetic raw material standard Chinese catalogue (version in 2010) "

Described freeze-drying excipient preparation, it primarily of functional component, adhesive agent composition, and needs to add or not add skeleton supporting agent and other auxiliary material (as thickening supensoid agent, antioxidant, flavouring and essence, skin penetration enhancer, pH adjusting agent etc.) according to preparation process.

Described skeleton supporting agent comprises the material such as amino acid (as amino acetic acid, alanine, glutamic acid etc.) and inorganic salts (as sodium phosphate, aluminium silicate etc.) being not limited to sugar (as maltose, trehalose etc.), sugar alcohol (as sweet mellow wine, sorbierite), 2-12 carbon atom.

Other described auxiliary material is including but not limited to thickening supensoid agent, antioxidant, flavouring and essence, skin penetration enhancer, pH adjusting agent etc.; Wherein thickening supensoid agent can be selected from the combination etc. of any one or they in the natural origin glue classes such as dextran, Arabic gum, xanthans, carragheen, pectin, konjac glucomannan, agar, carbomer, carrageenan and synthetic macromolecular compound and other polypeptide or polysaccharide; Described antioxidant includes but not limited to the compound of one or several in the polyhydric phenols of vitamin C and derivant thereof, anthocyanidin, resveratrol, plant origin; Described flavouring and essence include but not limited to the compound of mint flavored, chocolate flavoured, the essence such as vanilla flavored, caf, tea flavour, corn taste, lemon, milk flavor or more one or more fragrance; Described skin penetration enhancer include but not limited to lecithin, saponin(e, bay alkyd, the compound of any one or several in azone, tween, sapn; Described pH adjusting agent includes but not limited to any one in citric acid, tartaric acid, carbonate, sodium carbonate, phosphate or several compound.

The freeze-drying excipient preparation used in the packaging of freeze-drying excipient preparation provided by the utility model and delivery system and the packaging of solvent and delivery apparatus are any one device that can realize the utility model object, are preferably a kind of two-chamber mixing device.

Described two-chamber mixing device, comprises thrust unit (1) and two-chamber batch mixing cavity (9) two parts.

Described thrust unit (1) is made up of promotion cabin (12), accommodation chamber (15), push-rod piston device (7,8,11); While propelling thrust is provided, can also play a very good protection to the two-chamber batch mixing cavity of its inside.

Described two-chamber batch mixing cavity (9) is made up of dual chamber (numbering N1, numbering N2), two pistons (2,4), a bypass (6), a discharging opening (17), a discharging lid (10); For depositing freeze-drying excipients and solvent respectively before using, freeze-drying excipients can be mixed with solvent under the driving of power during use.

The promotion cabin (12) of described thrust unit (1) is a both ends open device; Its size and push-rod piston device profile and volume adapt; The lower end promoting cabin (12) has a locking device (14);

The accommodation chamber (15) of described thrust unit (1) is a both ends open device; Its size and two-chamber batch mixing cavity profile and volume adapt; The upper end of accommodation chamber (15) has another locking device (13), accommodation chamber (15) has the over cap (16) that can raise, open over cap (16) just two-chamber batch mixing cavity to be put into, the over cap (16) that closes just can be fixed and protect two-chamber batch mixing cavity, the lower end of described over cap (16) has bayonet socket or spiral mouth, the lower end of described bayonet socket or spiral mouth and two-chamber batch mixing cavity (9) matches, and can be fixed in described accommodation chamber (15) by two-chamber batch mixing cavity (9);

The locking device (14) of described promotion cabin (12) and the locking device (13) of accommodation chamber (15) match, and promotion cabin (12) and accommodation chamber (15) can form a firmly entirety by the sealed of locking device (13,14); The sealed form of locking device (13,14) can be that many clocks are various, as buckle-type, screw-type etc., as long as can realize above-mentioned purpose;

Described promotion cabin (12), accommodation chamber (15) or can have the materials such as the plastics of printing, metal, glass, pottery to make by blank, are intended to play effect that is fixing, that protect and identify;

Described push-rod piston device (7,8,11), comprises cut somebody's hair (11), push rod (7) and piston (8), push rod (7) and piston (8) is driven to move to discharging opening direction by cut somebody's hair (11), the liquid that air between piston (8) and piston (2) is squeezed in driven plunger (2) and liquid preparation chamber moves to discharging opening, liquid again driven plunger (4) moves to discharging opening direction, when the motion of piston (4) bottom exceedes bypass (6) below, liquid in liquid preparation chamber is under the driving of piston (2), piston (4) is directly got around by bypass (6), enter solid pharmaceutical preparation chamber, mix with freeze-drying excipient preparation wherein.The power resources that promotion is cut somebody's hair (11) can be manual, electronic or any its mode of moving that can drive such as mechanical movement, its actuating length and dynamics are the mode such as fixing or adjustable, and push rod (7) can be the related device that spring bar etc. can change length;

The dual chamber (numbering N1, numbering N2) of described two-chamber batch mixing cavity (9) is an overall cavity, and both ends open is fixed in accommodation chamber (15); Dual chamber (numbering N1, numbering N2), by piston (2,4) and discharging lid (10) formation of solid polycomplex preparation chamber (numbering N1) and liquid preparation chamber (numbering N2) two chambers, has one end of discharging lid (10) to be discharging opening 17; Discharging opening 17 can be any shape, as suction pipe shape, dropper shape, ball shape, spray first-class; Solid pharmaceutical preparation chamber is near discharging opening 17, and liquid preparation chamber is away from discharging opening 17; Freeze-drying excipient preparation (5) in solid pharmaceutical preparation chamber can be the freeze-drying excipient preparation of various formula, form, for being distributed into the preparation in solid pharmaceutical preparation chamber after carry out freeze-drying in forming mould; Solvent in liquid preparation chamber can for water, the nutrient solution with certain functional component, Essence and can with freeze-drying excipient directly with the use of various solvents; Dual chamber can adopt any material to make as required, and signable scale in dual chamber, reaches the object quantitatively used simultaneously.

A described bypass (6), be positioned at side, solid pharmaceutical preparation chamber, its width, slightly larger than the thickness of piston (4), can make the solvent in liquid preparation chamber by piston movement to forming opening during bypass (6) place thus mixing with the freeze-drying excipient preparation (5) in solid pharmaceutical preparation chamber.

A described discharging lid (10) is the device of salable discharger mouth, and chamber substance in vivo and external environment are isolated.

In use, two-chamber batch mixing cavity (9) includes the freeze-drying excipient formulation products that single uses metering, and use rear detachable replacing two-chamber batch mixing cavity (9), thrust unit (1) can Reusability.

The utility model also relates to the preparation method of above-mentioned freeze-drying excipient preparation.

The preparation of described freeze-drying excipient preparation is that after freeze-drying, the demoulding being fitted in the solid pharmaceutical preparation cavity in two-chamber blender is packed in forming mould.Preparation method comprises

A functional component, adhesive agent and other auxiliaries are become solution, emulsion or suspending fluid injection molding by (); Or by solid functional component injection molding, then add adhesive agent and other auxiliary material wiring solution-forming, emulsion or suspending fluid;

B solution that (a) obtains by () or suspending fluid carry out degassed in quantitative forming mould;

(c) (b) is obtained degassed after solution, emulsion or suspending fluid or the solution emulsion directly (a) obtained or suspending fluid, freezing at low temperatures;

The lyophilisation in quantitative forming mould of d preparation that (c) obtains by (), except desolventizing, obtain freeze-drying excipient preparation;

E freeze-drying excipient preparation that (d) obtains by () is detached into mould and loads packing device or its forming mould is exactly one of them cavity, directly assembles with this.

Wherein the described injection molding volume of step (a) is 0.01-5.0ml; Wherein injection molding can adopt the liquid-transfering devices such as accurate quantification pipet, liquid-transfering gun, electronic liquor-transferring rifle, also can adopt plunger pump, gear type pump, peristaltic pump etc., the solution configured or suspending fluid be injected quantitative forming mould; Wherein degas method can adopt centrifugal degassing method, vacuum degasification method and ultrasonic degas method etc.; The wherein freezing mode that can adopt liquid nitrogen or liquid, dry ice spray refrigeration, turbine expander refrigeration mode or cascade refrigeration mode, at-20 DEG C of-196 DEG C of temperature, rapidly by solution or suspending fluid is freezing becomes solid; Wherein freeze-drying adopts the degree of vacuum of 0.01-20 millibar, temperature freeze-drying between-70 DEG C of-50 DEG C of scopes.

The beneficial effects of the utility model are:

1. the stability of prolection composition: by this packaging and delivery system, achieve solid and liquid separately, high active substance stability is often bad, preserves with solid forms, its stability improves greatly, can improve result of use, reduce potential side reaction, Shelf-life;

2. unit dose package: compared with many measuring productses of routine, this packaging and delivery system are unit dose packages, its amount of liquid meets aircraft and carries with requirement, is easy to carry;

3. avoid polluting: pack freeze-dried powder form bottled with traditional double with the two aluminium of traditional freeze-drying figuration and compare, this packaging and all assembling process of delivery system complete in clear production district, do not have exposed component only to extrude from discharging opening, the microbial contamination in process for preparation can not be caused;

4. easy to use: compared with packing with the two aluminium of traditional freeze-drying figuration, this packaging and delivery system, without the need to opening packaging, put into the palm, add liquid again, the complicated occupation mode coordinated with the both hands pointing mixing, only need one to push away or one by startup push-rod piston device, after mixing completely, open discharging opening carry out use two actions, very convenient;

5. reduce costs: compared with freeze-dried powder, there is no complicated two Bottle and bottle cap systems; Compared with packing with the two aluminium of traditional freeze-drying figuration, do not have complicated support and structure design, full automation is packed, and significantly reduces productive costs;

Accompanying drawing explanation

Fig. 1 is packaging and delivery system device each parts decomposition texture schematic diagram of freeze-drying excipient preparation;

Fig. 2-Fig. 3 is packaging and each component combination schematic diagram of delivery system device of freeze-drying excipient preparation;

Fig. 4-Fig. 9 is the packaging of freeze-drying excipient preparation and the use step diagram of delivery system.

Detailed description of the invention

Further illustrate the utility model by the following examples, but the utility model is not restricted to this.

The bottom of the cavity of following examples indication, refers to the far-end of cavity away from discharging opening; The top of bypass (6) refers to the one end near discharging opening, and the below of bypass (6) refers to the other end away from discharging opening; The top of piston refers to piston one end near discharging opening, and the bottom of piston refers to the other end of piston away from discharging opening.

Embodiment 1:

Vitamin C: Propiram=5:1, mixed powder 50mg is filling in solid form enters 0.4 milliliter of forming mould, then after remaining 10mg being dissolved with 0.4 ml water, filling enter forming mould containing powder, after freeze-drying, the freeze-drying excipient preparation obtained is loaded in the solid pharmaceutical preparation chamber with the two-chamber batch mixing cavity of the plastic material of bypass 6, then the piston 4 of silica gel material is fitted into below the bottom in the solid pharmaceutical preparation chamber of plastic material, bypass 6; In the liquid preparation chamber of the plastic material that the piston 2 that deionized water 2 milliliters is filled into silica gel material is isolated; Add the piston 2 of silica gel material afterwards, make that liquid is complete to be stored in liquid preparation chamber, can not ooze out between the piston 4 of silica gel material and the piston 2 of silica gel material, namely obtain the two-chamber batch mixing cavity comprising freeze-drying excipient preparation and solvent, with the accommodation chamber of transparent plastics material, promote to form two-chamber blender device together with cabin and hand push rod piston.

By a push-rod piston device 7 during use, 8, 11 load in promotion cabin 12, promotion cabin 12 and accommodation chamber 15 are locked, again two-chamber batch mixing cavity 9 is loaded in accommodation chamber 15, cut somebody's hair 11 driving push rods 7 and piston 8 of promotion moves to discharging opening direction, the liquid that air between piston 8 and piston 2 is compressed in driven plunger 2 and liquid preparation chamber moves to discharging opening, liquid again driven plunger 4 moves to discharging opening direction, when bottom piston 4, motion exceedes below bypass 6, liquid in liquid preparation chamber is under the driving of piston 2, piston 4 is directly got around by bypass 6, enter solid pharmaceutical preparation chamber, mix with freeze-drying excipient preparation wherein, continue driven forward push rod to contact to piston 2 top with bottom piston 4, 2 ml deionized water in liquid preparation chamber mix with freeze-drying excipient preparation completely, formed containing 2.5% ascorbic solution, open discharging lid 10) continue to promote push-rod piston device 7,8,11, drive piston 2 to press piston 4, aforesaid mixed solution is extruded from discharging opening 17, is directly applied to face, become modern cosmetics.

The two-chamber batch mixing cavity be finished can be taken out after using and abandon, next time, the used time loaded onto new two-chamber batch mixing cavity again.

Embodiment 2:

EGF stoste, gelatin, gelatin hydrolysate is added after thawing, be mixed with containing the EGF (weight ratio) of 5/100000ths, the gelatin+gelatin hydrolysate solution containing 5%, fillingly enter 0.1 milliliter of forming mould, in the solid pharmaceutical preparation chamber of the dual chamber of the clear glass material of the shaping rear tape loaded scale of freeze-drying, then the piston 4 of quality of rubber materials is fitted into below the bottom in solid pharmaceutical preparation chamber, bypass 6; Again by liquid preparation chamber that the piston 2 that the hyaluronic acid solution 2 milliliters of 3% is filled into quality of rubber materials isolates; Add the piston 2 of quality of rubber materials afterwards, make that liquid is complete to be stored in liquid preparation chamber, can not ooze out between the piston 4 of quality of rubber materials and the piston 2 of quality of rubber materials, namely obtain the two-chamber batch mixing cavity comprising freeze-drying excipient preparation and solvent, with the accommodation chamber of transparent plastics material, promote to form two-chamber blender device together with cabin and hand push rod piston.

By a push-rod piston device 7 during use, 8, 11 load in promotion cabin 12, promotion cabin 12 and accommodation chamber 15 are locked, again two-chamber batch mixing cavity is loaded in accommodation chamber 15, cut somebody's hair 11 driving push rods 7 and piston 8 of promotion moves to discharging opening direction, the liquid that air between piston 8 and piston 2 is compressed in driven plunger 2 and liquid preparation chamber moves to discharging opening, liquid again driven plunger 4 moves to discharging opening direction, when bottom piston 4, motion exceedes below bypass 6, liquid in liquid preparation chamber is under the driving of piston 2, piston 4 is directly got around by bypass 6, enter solid pharmaceutical preparation chamber, mix with freeze-drying excipient preparation wherein, continue driven forward push rod to contact to piston 2 top with bottom piston 4, the hyaluronic acid solution of 2 milliliter 3% in liquid preparation chamber all mixes with freeze-drying excipient preparation, form the EGF containing 2.5ppm, 0.25% gelatin and gelatin hydrolysate, 3% hyaluronic solution, open discharging lid 10, continue to promote push-rod piston device 7,8,11, drive piston 2 to press piston 4, observe scale and quantitative aforementioned mixed solution is extruded from discharging opening 17, be directly applied to face, become modern biotechnology cosmetics.

Embodiment 3:

Arasaponin: PVP=30mg:15mg, is mixed with solution, is filled into 0.3ml forming mould, loads in the solid pharmaceutical preparation chamber of the dual chamber of clad aluminum material after freeze-drying, then the piston 4 of silica gel material is fitted into the bottom in solid pharmaceutical preparation chamber, the below of bypass 6; In the liquid preparation the chamber again piston 2 that the deionized water 1 milliliter containing natural essence is filled into silica gel material isolated; Add the piston 2 of silica gel material afterwards, make that liquid is complete to be stored in liquid preparation chamber, can not ooze out between the piston 2 of silica gel material and the piston 4 of silica gel material, namely obtain the two-chamber batch mixing cavity comprising freeze-drying excipient preparation and solvent, with the accommodation chamber of aluminum material, promote to form two-chamber blender device together with cabin and electric pushrod piston.

By electric pushrod piston apparatus 7 during use, 8, 11 load in promotion cabin 12, promotion cabin 12 and accommodation chamber 15 are locked, again two-chamber batch mixing cavity is loaded in accommodation chamber 15, pin power button, cut somebody's hair 11 driving push rods 7 and piston 8 of electric device moves to discharging opening direction, the liquid that air between piston 8 and piston 2 is compressed in driven plunger 2 and liquid preparation chamber moves to discharging opening, liquid again driven plunger 4 moves to discharging opening direction, when bottom piston 4, motion exceedes below bypass 6, liquid in liquid preparation chamber is under the driving of piston 2, piston 4 is directly got around by bypass 6, enter solid pharmaceutical preparation chamber, mix with freeze-drying excipient preparation wherein, continue to pin power button driven forward push rod to contact to piston 2 top with bottom piston 4, 1 ml deionized water in liquid preparation chamber all mixes with freeze-drying excipient preparation, form the solution containing 3% arasaponin, open discharging lid 10, continue to pin power button and promote push rod 7 and piston 8, drive piston 2 to press piston 4, by aforesaid mixed solution by extruding in discharging opening 17, directly oral, become health food.

Embodiment 4:

Bilberry fruit P.E: Propiram=100mg:15mg, be mixed with solution, perfusion enters 0.5 milliliter of forming mould, loads in the solid pharmaceutical preparation chamber of the dual chamber of plastic material, then the piston 4 of silica gel material is fitted into the bottom in solid pharmaceutical preparation chamber, the below of bypass 6 after freeze-drying; In the liquid preparation chamber isolated by the piston 2 that 20 ml deionized water containing natural colouring matter are filled into silica gel material again, add the piston 2 of silica gel material afterwards; Make that liquid is complete to be stored in liquid preparation chamber, can not ooze out between the piston 2 of silica gel material and the piston 4 of silica gel material, namely obtain the two-chamber batch mixing cavity comprising freeze-drying excipient preparation and solvent, with the accommodation chamber of aluminum material, promote to form two-chamber blender device together with cabin and full automaticity mixing weighing push-rod piston.

By full automaticity mixing weighing push-rod piston device 7 during use, 8, 11 load in promotion cabin 12, promotion cabin 12 and accommodation chamber 15 are locked, again two-chamber batch mixing cavity is loaded in accommodation chamber 15, pin power button, cut somebody's hair 11 driving push rods 7 and piston 8 of electric device moves to discharging opening direction, the liquid that air between piston 8 and piston 2 is compressed in driven plunger 2 and liquid preparation chamber moves to discharging opening, liquid again driven plunger 4 moves to discharging opening direction, when bottom piston 4, motion exceedes below bypass 6, liquid in liquid preparation chamber is under the driving of piston 2, piston 4 is directly got around by bypass 6, enter solid pharmaceutical preparation chamber, mix with freeze-drying excipient preparation wherein, when piston 2 top contacts with bottom piston 4, 20 milliliters in the liquid preparation chamber deionized waters containing natural colouring matter mix with freeze-drying excipient preparation completely, form the solution containing 0.5% Bilberry fruit P.E, open discharging lid 10, regulate the metering needed, again press power button, push rod 7 drives piston 2 to press piston 4, is extruded by quantitative aforementioned mixed solution from discharging opening 17, directly oral, forms solid beverage food.

Packaging structure of the present utility model is not limited to form cited in embodiment, and embodiment is only preferred embodiment of the present utility model, can not limit protection domain with this.All with the simple or equivalent change described in right of the present utility model and modification, all belong to protection domain of the present utility model.

Claims

1. the packaging of a freeze-drying excipient preparation and delivery system, comprise freeze-drying excipient preparation, solvent and packaging and send packaging and the delivery apparatus of described freeze-drying excipient preparation and solvent, it is characterized in that in described packaging and delivery apparatus, comprising a two-chamber mixing device, wherein solvent and freeze-drying excipient preparation are stored in the different cavitys of the two-chamber batch mixing cavity (9) in two-chamber mixing device respectively, solvent and freeze-drying excipient preparation is made can immediately to mix and derive in use by the interaction of each parts of two-chamber mixing device, described two-chamber mixing device comprises thrust unit (1) and two-chamber batch mixing cavity (9), described thrust unit (1) is by promotion cabin (12), accommodation chamber (15) and push-rod piston device (7, 8, 11) form.

2. the packaging of freeze-drying excipient preparation as claimed in claim 1 and delivery system, is characterized in that described promotion cabin (12) is a both ends open device; Its size and described push-rod piston device (7,8,11) profile and volume adapt; The lower end promoting cabin (12) has a locking device (14).

3. the packaging of freeze-drying excipient preparation as claimed in claim 1 and delivery system, is characterized in that described accommodation chamber (15) is a both ends open device; Its size and two-chamber batch mixing cavity (9) profile and volume adapt; The upper end of accommodation chamber (15) has another locking device (13); Accommodation chamber (15) has the over cap (16) that can raise; open over cap (16) just two-chamber batch mixing cavity to be put into; the over cap (16) that closes just can be fixed and protect two-chamber batch mixing cavity; the lower end of described over cap (16) has bayonet socket or spiral mouth; the lower end of described bayonet socket or spiral mouth and two-chamber batch mixing cavity (9) matches, and two-chamber batch mixing cavity (9) can be fixed in described accommodation chamber (15).

4. the packaging of freeze-drying excipient preparation as claimed in claim 1 and delivery system, it is characterized in that described promotion cabin (12) and accommodation chamber (15) by locking device (13,14) sealed can be formed one firmly overall.

5. the packaging of freeze-drying excipient preparation as claimed in claim 1 and delivery system, is characterized in that described two-chamber batch mixing cavity (9) is made up of dual chamber, two pistons (2,4), a bypass (6), a discharging opening (17), a discharging lid (10).

6. the packaging of freeze-drying excipient preparation as claimed in claim 5 and delivery system, is characterized in that described dual chamber has solid pharmaceutical preparation chamber and liquid preparation chamber; Solid pharmaceutical preparation chamber is the cavity near discharger lid (10) part, and liquid preparation chamber is the cavity away from discharging lid (10) part; Solid pharmaceutical preparation chamber and liquid preparation chamber are two separate space that single overall cavity is separated into by piston.

7. the packaging of freeze-drying excipient preparation as claimed in claim 5 and delivery system, it is characterized in that a described bypass (6), be positioned at side, solid pharmaceutical preparation chamber, the solvent in cavity can be made by piston movement to forming opening during bypass place thus mixing with freeze-drying excipient preparation.