CN1965893A - A liquid preparation for treating allergic rhinitis - Google Patents

Abstract

A liquid preparation for treating allergic rhinitis, the composition weight percent of the liquid preparation is: perilla seed oil 1.5-4.2%, propylene glycol 5-10%, Tween 80 0.25-1.5%, Cremophor RH40 5-15%, Borneol 1-2%, lauryl alcohol 1-2%, isoprinosine 0.05-0.2%, uridine acid 0.1-0.5%, sodium metabisulfite 0.1%, ethylparaben 0.2%, distilled water to 100%. Compared with the prior art, the present invention has the advantages of simple preparation process, good stability, high patient compliance, rapid onset of treatment for allergic rhinitis, and no side effects, wide source, homology of medicine and food, easy to carry, The curative effect on perennial or seasonal allergic rhinitis is better than that of existing similar drugs, and the cure rate can reach 91.2% within 14 days.

Description

The liquid preparation that a kind of treatment of allergic rhinitis is used

Technical field

The present invention relates to a kind of medicinal preparation that derives from vegetable material that contains, the liquid preparation that particularly a kind of treatment of allergic rhinitis is used.

Background technology

Allergic rhinitis is to be the nasal mucosa chronic inflammation of tissue disease of mediation by IgE.In pathological process, multiple struvite cell participates in and by various media, the cytokine of its release be arranged in some inflammatory activity materials of nasal mucosa tissue, and all the appearance to generation, development and the sniffle of inflammation plays an important role.The common drug of treatment of allergic rhinitis has antihistaminic, Elocon, chromone class medicine, Decongestant medicine and anti-leukotriene medicine etc. at present.Wherein antihistaminic is rapid-action, but to the nasal congestion weak effect; Elocon can suppress the inflammatory reaction of nasal mucosa, but onset is slow, and inapplicable to some crowd; Chromone class medicine only is suitable for prophylactic treatment; The Decongestant medicine can be alleviated the nasal obstruction symptom, but invalid to other symptom, and prolonged application easily produces medicamentous rhinitis; Anti-leukotriene medicine better tolerance, but have only oral formulations at present.The medicine of still using clinically in the treatment of allergic rhinitis of seeking a kind of rapid-action, good effect and have no side effect.

By the Fructus Perillae that Chinese Pharmacopoeia recorded, have antiinflammatory, anti-allergic effects, modern pharmacology proves: Fructus Perillae contains two big class antiallergic, anti-inflammatory substance, i.e. fatty acid composition and polyatomic phenol composition, they all belonged to sensitive media antagonist class.Perilla oil be with the dry mature fruit Fructus Perillae squeezing of labiate Folium Perillae (Perillafrutescens[L] Britt) fatty oil, perilla oil contains higher alpha-linolenic acid (can up to more than 70%) composition, in vivo in the metabolic process, by the competition enzyme system, can suppress linoleic acid transforms to arachidonic acid, thereby arachidonic level in the reduction body reduces the generation that prostaglandin waited sensitive media.By adjusting to the T-cell function, can suppress Th2 cytokine secretion function, it also has the effect that suppresses leukotriene, blood vessel activation factor and histamine simultaneously, have stronger anti-allergic effects, especially the variation of the physical property light radiation and the temperature difference, the stimulation of chemicals, anaphylaxis nettle disease, allergic rhinitis, pharyngitis, the asthma cough that shrimp Eriocheir sinensis class invertebrates protide food causes are all had good effect clinically.Rhinitis subjective symptoms such as sneeze, watery nasal discharge and nasal obstruction there is good improvement effect.

Modern medicine study confirms, its pathogen of most of infectious diseases is invaded body by mucous membrane surface (as skin, respiratory mucosa, gastrointestinal tract mucosa, reproductive tract mucosa etc.), body has 80% infection at first to occur in mucosa approximately, as seen the importance of mucosa-immune is so there is the scholar to propose the notion of " mucosa-immune system ".Present stage, the vaccine that uses clinically all is main path with injection.Because conventional vaccinate can only produce the humoral immunoresponse(HI) of general, then can't produce corresponding local immune response and permanent immunological memory power to pathogen invasion position.Can have by the immunifacient route of administration of mucosa: oral administration, nasal mucosa medicine administration, pulmonary administration, rectally and vagina administration etc., wherein, the nasal mucosa immunity is proved to be and is the most effective and approach easily.

Nasal cavity has about 150cm ²Abundant mucosa has serial fine hair and epithelial cell on the mucosa, fine hair increases the nasal mucosa absorption area, and a large amount of capillary network under the mucosa can be absorbed medicine very soon.Nasal-cavity administration have drug absorption rapidly, after the administration onset time fast, no first pass effect, no gastrointestinal reaction, bioavailability advantages of higher, that medicine can reach is efficient, quick-acting, safe, therapeutic effect easily.The Folium Perillae source is wide, inexpensive, and the basis of medicine-food two-purpose is widely arranged.So the exploitation of pair cell factor antagonist-Folium Perillae preparation has broad prospects.

Summary of the invention

The purpose of this invention is to provide the liquid preparation that a kind of treatment of allergic rhinitis is used, wherein effective dose is a perilla oil, perilla oil day dosage be 0.015～0.40g; This liquid preparation contains selected immunological adjuvant, solubilizing agent, and the mucosa absorption enhancer, stabilizing agent and antiseptic are used for the treatment of allergic rhinitis and have rapid-action, good effect and advantage without any side effects.

Immunological adjuvant in this liquid preparation is selected uridylic acid, inosine pranobex for use, have obvious enhancing in vivo or improve the immunoreactive ability of main body, they can be by changing antigenic physical behavior, as increased antigenic surface area, make antigen be easy to by macrophage phagocytic, promote the contact between the lymphocyte, strengthen the effect of helper T cell, the division that stimulates primed lymphocyte and plasma cell and produce the mechanisms of action such as antibody, change the ability of immune response or change the production of antibodies type, make the antigenicity medicine bring into play better pharmacology curative effect.

The mixture of propylene glycol, tween, polyoxyethylene hydrogenated Oleum Ricini Cremophor RH40 is selected in solubilizing agent for use; The mucosa absorption enhancer is selected the mixture of Borneolum Syntheticum, lauryl alcohol for use; Stabilizing agent is selected a kind of among sulphite, the cetyl trimethyl ammonium bromide CTAB, perhaps its mixture for use; Antiseptic is selected a kind of in methyl hydroxybenzoate, the ethyl hydroxybenzoate, perhaps its mixture for use.Drug usage: collunarium, perhaps nasal spray.

The liquid preparation that a kind of treatment of allergic rhinitis is used is characterized in that the composition percentage by weight of this liquid preparation is:

Perilla oil 1.5～4.2%

Propylene glycol 5～10%

Tween 80 0.25～1.5%

Cremophor?RH40 5～15％

Borneolum Syntheticum 1～2%

Lauryl alcohol 1～2%

Inosine pranobex 0.05～0.2%

Uridylic acid 0.1～0.5%

Sodium pyrosulfite 0.1%

Ethyl hydroxybenzoate 0.2%

Distilled water adds to 100%

Its preparation method is as follows: by composition proportion, take by weighing Tween 80, CremophorRH40, ethyl hydroxybenzoate, and the water of total amount 60%, be heated to 60 ℃ be dissolved into aqueous solution after, natural cooling; By composition proportion, taking by weighing perilla oil, Borneolum Syntheticum, lauryl alcohol is dissolved in the propylene glycol, slowly join in the above-mentioned aqueous solution, the limit edged stirs, get clear liquid, dissolve in inosine pranobex, uridylic acid, sodium pyrosulfite then successively, add water to capacity, mixing, packing, sterilization obtain required liquid preparation.。

Usage and curative effect: every day 3-4 time, collunarium, each 1-2 drips.Alleviated in 7 days, cure rate can reach 91.2% in 14 days.

The liquid preparation that a kind of treatment of allergic rhinitis is used is characterized in that the composition percentage by weight of this liquid preparation is:

Perilla oil 2～3%

Propylene glycol 8～10%

Tween 80 1～1.5%

Cremophor?RH40 10～15％

Borneolum Syntheticum 1～2%

Lauryl alcohol 1～2%

Inosine pranobex 0.1～0.2%

Uridylic acid 0.1～0.2%

Sodium pyrosulfite 0.1%

Ethyl hydroxybenzoate 0.2%

Distilled water adds to 100%

With prior art relatively, outstanding advantage of the present invention is: preparation process thereof is simple, good stability, patient's compliance height, treatment of allergic rhinitis is rapid-action and without any side effects, wide material sources, integration of edible and medicinal herbs, easy to carry, long-term or pollinosis's curative effect are better than existing similar medicine, cure rate can reach 91.2% in 14 days.

The specific embodiment

Embodiment 1:

The liquid preparation that a kind of treatment of allergic rhinitis is used, when preparing this liquid preparation 100g: take by weighing Tween 80 1.5g, Cremophor RH40 5g, ethyl hydroxybenzoate 0.2g puts into the distilled water of 60g, be heated to 60 ℃ after natural cooling become aqueous solution; With perilla oil 1.5g, Borneolum Syntheticum 1g, lauryl alcohol 2g, after being dissolved in the propylene glycol of 5g, slowly join in the above-mentioned aqueous solution, the limit edged stirs, and obtains clear liquid, add inosine pranobex 0.05g then successively, uridylic acid 0.5g, sodium pyrosulfite 0.1g, adding distil water is to capacity, mixing, packing, sterilization obtain the liquid preparation 100g that treatment of allergic rhinitis is used.

Embodiment 2:

The liquid preparation that a kind of treatment of allergic rhinitis is used, when preparing this liquid preparation 100g: take by weighing Tween 80 0.25g, Cremophor RH40 15g, ethyl hydroxybenzoate 0.2g puts into the distilled water of 60g, be heated to 60 ℃ after natural cooling become aqueous solution; With perilla oil 4.2g, Borneolum Syntheticum 2g, lauryl alcohol 1g, after being dissolved in the propylene glycol of 10g, slowly join in the above-mentioned aqueous solution, the limit edged stirs, and obtains clear liquid, add inosine pranobex 0.2g then successively, uridylic acid 0.1g, sodium pyrosulfite 0.1g, adding distil water is to capacity, mixing, packing, sterilization obtain the liquid preparation 100g that treatment of allergic rhinitis is used.

Claims (2)

1. a liquid preparation for the treatment of allergic rhinitis, characterized in that the composition weight percentage of the liquid preparation is: Perilla seed oil 1.5～4.2% Propylene Glycol 5～10% Tween 80 0.25～1.5% Cremophor RH40 5～15％ Ice flakes 1～2% Lauryl alcohol 1～2% Isoprinosine 0.05～0.2% Uridine 0.1～0.5% Sodium metabisulfite 0.1% Ethylparaben 0.2% Add distilled water to 100% 2. The liquid preparation according to claim 1, characterized in that the composition weight percentage of the liquid preparation is: Perilla seed oil 2～3% Propylene Glycol 8～10% Tween 80 1～1.5% Cremophor RH40 10～15％ Ice flakes 1～2% Lauryl alcohol 1～2% Isoprinosine 0.1～0.2% Uridine 0.1～0.2% Sodium metabisulfite 0.1% Ethylparaben 0.2% Add distilled water to 100%