CN1965650A - Multiple metal ion chelated green antibacterial agent of chitosan - Google Patents
Multiple metal ion chelated green antibacterial agent of chitosan Download PDFInfo
- Publication number
- CN1965650A CN1965650A CNA2005101148079A CN200510114807A CN1965650A CN 1965650 A CN1965650 A CN 1965650A CN A2005101148079 A CNA2005101148079 A CN A2005101148079A CN 200510114807 A CN200510114807 A CN 200510114807A CN 1965650 A CN1965650 A CN 1965650A
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- shitosan
- chitin
- acid
- powder
- agent
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Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to an environment-friend antibacterial agent, wherein the inventive antibacterial agent can improve immunity, accelerate cell growth and repair. The invention is characterized in that: its corn is crust element and combined Ag, Zn, Cu metal ion which is removed from acetyl. The solution of said antibacterial agent is in yellow, green, blue and transition color, or transparent achromatic color. And the powder agent can be micro crystal, nanometer powder, or film agent.
Description
One. technical field
The present invention relates to chitin derivativ chelating Zn, metal ions such as Cu, Ag, manufacturing process through the green antibacterial agent of controlled micro crystallization or nanorize, reach and mainly be suitable for various medical purposes prescriptions and preparation, Chinese herbal medicine extract, essential oil and Polyphenols plant alexin have been adopted in the prescription, antioxidant etc.Its purposes also contains food agronomy, weaving gently change, health care.
Two. background of invention
Found penicillin since over half a century, as if people be sure of: the mankind can tackle the challenge of all kinds of pathogene completely surely, and communicable disease no longer is a significant threat.But new century, beginning new millennium, visiting frequently along with " superbacteria " and pernicious shades such as viral SARS, H5N1, HIV, along with the antibiotic resistance bacterial strain constantly begin to crop up and the liter of synthetic medicament (comprising bactericide) ecological pernicious influences such as " adverse drug reactions " rises, at the very moment that antibiotic antipathogen Development of Materials direction is argued, adjusted, people are expecting to have more and more ecological optimum, eco-friendly green materials available just in a hurry.Antibacterial green material in the scientific concept probably can define like this:
● effectively tackle all kinds of pathogene (bacterium, fungi, virus etc.) and infect, do not stay " drug resistance " back and lose;
● do not upset that ecology (people and biology) is normal, the kind group relation of balance;
● do not bring pernicious influence residual and accumulation property to ecotope;
● can or move by human body, plant, microbial decomposition absorbs, and maybe can incorporate the koinomatter metabolic cycles.
The anti-biotic material " bright spot " that meets the condition of enumerating substantially all belongs to nature or bionical source, as belong to Polyphenols, flavonoids, terpene essential oil, some saponins and the brand-new materials such as alkaloid, antibacterial polypeptide of plant alexin class, wherein, because of resource abundance, functional activity and broad-spectrum antibacterial property, give birth to the compatible and safety of body, multinomial dominants such as the multiple-factor controllability of antibacterial action then have chitin derivativ-be the unique amino cationic polysaccharide of natural world.The monomer N-acetyl-D-amino glucose and the N-Glucosamine of chitin and main derivative thereof all are neccessary compositions in the tissue.The antibiotic property of chitin derivativ such as chitin, carboxylation chitin is derived from:
● directly effect.With the cationic is that the amine sugar big molecule of straight chain of characteristics and the electrostatic interaction of mushroom cell membrane elecrtonegativity sized molecules cause cohesion or cause broken wall, suppress respiratory chain electronics transfer etc., thereby perhaps remove adhere to (desorption) the host tissue cell by destruction thalline adhesive organ, coherent substance.
● indirectly-acting.By strengthening the immune defence mechanism of host's body, activated cell and humoral factor (as interferon, alexin), perhaps the acid-base value by changing environment, suppress pathogene in conjunction with the essential trace element of pathogenic growth.Chitin derivativ is treated probio, nonpathogenic bacteria, conditioned pathogen and harmful pathogen and is usually showed delicate difference, they can be growth factor (lactic acid bacteria, bifid bacterium etc.), non-AF (most bacterial parasite) and typical AF (G positive bacteria etc.).Explanation part for this class difference can be explored by, hydrophily electrical to all kinds of microorganism after births, secretion enzyme and physiology, biochemical characteristics.
The above nature characteristics of chitin derivativ are added the following active ameliorative measure of strengthening, and this very large natural resources is able in " antibacterial green " field performance great potential:
(1) molecule modification: as by strengthen charge density, grafting active group, change molecular weight and water-soluble, carry out nanorize, controlled micro crystallization (" quantum " level effect).By improving the deacetylation (increase charge density) of chitin, reduce molecular weight (increasing water-soluble and molecular activity), by carboxylation or sulfonation (increase antimicrobial spectrum).
(2) compound with metal or halogen: no matter some multivalence or transition metal molecule or ionic state have biocidal property (protein coagulating sex change principle) more.Existing so far many and natural or synthetic macromolecular material is combined into antibacterial agent, as lactoferrin (to helicobacter pylori), protargin (or Zn or Cu), yellow Siberian cocklebur glucoside zinc, acrylic acid silver (or zinc one class tool is antibacterial, the surgical materials of hemostasia effect, as the Amicor dressing of the U.S.), povidon iodine, chitin iodine, alginic acid silver or the like.
(3) compound is collaborative: as electropositive collaborative, as adding quaternary ammonium salt, hibitane; The dispersiveness (increase contacts with bacterial cell) that increases strand is added nonionic agent; Collaborative as the interpolation flavonoids of non-oxidizability; It is protonated to utilize different organic machine acid to carry out, as adding lactic acid (treatment gynaecological imflammation); High-concentration acetic acid inhibition communicate illness, salicylic acid suppresses fungi.Can also extensively adopt existing each series bactericidal agent, the collaborative or controlled release system of antibiotic composition compound, reduce the latter's using dosage and toxic and side effect.
Although above-mentioned all discoveries and trial have been arranged, strengthening antimicrbial power, increasing antibiotic pedigree, machine-processed diversification, improving the preparation safety convenience, improve aspect the physico-chemical properties such as color and luster sense organ of preparation so far, still have a large amount of problems of excavating of being worth.Especially as the isoionic compound formulation of Cu, Ag, often violate bad colour generation problem (blackening, change ash, browning etc.) in the use
Three. summary of the invention
The objective of the invention is to propose one make novel, based on the method for " green antibacterial agent " of chitin derivativ, be characterized in: 1. adopted the technology of controlled micro crystallization or nanorize that chitin derivativ is existed with the form of nanometer or crystallite particle; 2. chitin derivativ nanometer or crystallite particle appropriately ratio transition metal ionss such as Zn, Cu, Ag are carried out chelating make and become " green big molecule " 3. this " green big molecule " that a class antibacterial functions greatly strengthens except controlled powerful sterilizing power, the controlled wide wide antimicrobial spectrum of tool also, good physiological safety and satisfied color and luster outward appearance; 4. this kind nanometer or controlled micro crystallization chitin derivativ can disperse in the medium (as water) of neutrality, both can be used for from external application (skin, mucous membrane, the surface of a wound) for oral administration anti-infectively to various operations, prevent tissue adhesion, suppress scar to cleaning, the sterilization of human body, animal, the close surrounding medium that contacts of food.
The present invention is achieved by following scheme: select suitable chitin derivativ for use and it is made the high degree of dispersion water slurry of solution or controlled micro crystallization after highly purified.The chitin derivativ of solution state is then used the ionic gel technology and is made and change the nanometer suspension into, then with this two classes suspension and Zn, Cu, three kinds of ions of Ag (salt) according to the gram molecule ratio of setting, fit in chitin derivativ-Zn, Cu, Ag compound by adsorb, exchange, boil together to react.
Chitin derivativ involved in the present invention comprises water-soluble; water-soluble part in rare organic acid solution; and water-insoluble all kinds of chitin derivativs, as the part chitosan; N-acidylate chitin; carboxymethyl chitosan; carboxylic butyl chitin; the ethanol chitin; the hydroxypropyl chitin; the controlled micro crystallization chitin; the controlled micro crystallization chitin; the sulphation chitin; the phosphorylation chitin; the various salts of chitin such as chitin citrate; the chitin ascorbate; the chitin stearate; the chitin citrate; the chitin salicylate; chitin bromine compound; the chitin Surgidine; quaternized chitin.
Chitin derivativ nanoparticle involved in the present invention is meant particle suspension or the powder of particle diameter 1-1000nm, average out to 10-300nm; The controlled micro crystallization particle of chitin derivativ is meant particle diameter 0.3-50 μ m, particle suspension or powder.
These from 10nm to 50 μ m just in time be macrophage can directly engulf the grain warp, highly beneficial to immune reinforcement, purpose according to the invention.
The cooperating of chitin derivativ particle involved in the present invention and Zn, Cu, Ag ion (chelating) can be that an independent metal ion species such as Zn or Cu or Ag also can Cheng Shuanru Zn+Cu or Zn+Ag or Cu+Ag ions, also can Zn, Cu, the whole three kinds of ions of Ag cooperate with chitin derivativ.Reaching gratifying colour generation such as colourless or extremely shallow yellow, yellow green, blueness, sky blue, dark brown, orange, grayish green, grey indigo plant etc. all can reach by the ratio of allotment ion.The source of Zn, Cu, Ag ion can be their corresponding separately water soluble salt or oxides, as their sulphate, nitrate, phosphate, chloride (hydrochloride) or various organic acid salt.
End-product of the present invention can be carry Zn, Cu, Ag nanoparticle or controlled micro crystallization various concentration suspension or borrow centrifugal, filter, concentrate, powder that technology such as vacuum, freeze-drying, spraying make, and the various practical formulation of utilizing suspension of the present invention or powder to make by various preparation techniques: as film, cavernous body, spray, hollow granule (pulverizing after the freeze-drying).
The powder of chitin derivativ of the present invention promptly can be solution transparent fully, that colour generation is extremely shallow after the diluted acid dissolving, utilize this solution can prepare various " dissipation is gone out " liquors that are fit to multiple use, as limpid tempting oral cavity gargarism class.
The safety that chitin derivativ involved in the present invention carries Zn, Cu, Ag ion product and preparation is that the safety with chitin derivativ itself is a prerequisite, in addition, the Zn that combines with chitin derivativ, Cu, Ag ion use at low dosage and all belong to the essential trace element (Zn, Cu) that meets health or health care meaning, or have proved the trace element (Ag) that is not absorbed by the body, utilizes.Zn is the prothetic group composition of human body 300 plurality of enzymes, and it is just apparent active that these enzymes have Zn to exist.Zn can with the phosphate of the sulfydryl of epicyte protein, phosphatide in conjunction with strengthening the stability of film, and with anti-oxidant---the integrality of Green Tea Extract diaphragm and cellularity.Physiology courses such as the growth of organism, breeding, immunity, trauma repair, Zn is all indispensable.Cu also is the activated centre of cytochrome oxidase, peroxidating dismutase, blue copper protein etc.Cu is beneficial to the synthetic and erythrocyte maturation of haemoglobin.Cu is the constituent of serum immune globulin, plays an important role in 1gM, 1gG generate.Zn, Cu all are important component of body immune system.Ag is a kind of former coagulant, thereby can play the hemostasis effect with the combined with protein of anticoagulant in the serum.Ag, Pt, Au also tool strengthen the effect of the immunity of animal or ovum.
Importantly: chitin derivativ to the chelate of Zn, Cu, Ag ion discharge Zn, Cu under animals and plants, water, the relative temperate condition of native surrounding medium usually, the Ag ion is very slow; what antibacterial under its little dosage helped that human body preponderates quantity stations probio, fungal component, to keep the symbiosis ecological balance.Its main antibacterial mechanism is that " fine motion " effect or contact action are not to resemble that heavy dose enters the body fluid circulation most chemical bactericides or the antibiotic, is dispersed in the free responding of formula.
Special emphasized a bit be: the general equal represent dark brown of Ag polymer antibacterial agent of carrying, but the present invention adopted with the preset proportion of Zn, Cu and cooperate, and overcome this obstacle fully.The ratio of Zn, Ag must not be less than 1, and preferably 10: 0.1-8.
Technology of the present invention comprises:
(1) chitin derivativ controlled micro crystallization and nanorize technology;
(2) technology that cooperates of controlled micro crystallization and nanorize particle chitin derivativ and Zn, Cu, Ag ion;
(3) use year Zn, a Cu, Ag ion controlled micro crystallization and nanorize chitin derivativ (powder or suspension) and make spray, cavernous body, paste practicability preparations such as (cream).
1. controlled micro crystallization and nanorize technology;
Nanorize:
Highly purified chitin derivativ such as chitosan or chitin salt are mixed with the aqueous solution of 0.5-2.0%, the PH condition such as the PH4.6-4.8 that are adjusting, add polyphosphoric acids sodium solution that concentration is 0.25-1.0%, get sediment through 30 minutes centrifuging and taking of 9000g, by 3: 1 (V/V) in the time of high degree of agitation again through suspension washing and centrifugal powder (through vacuum drying) or the suspension (being diluted to deionized water) that promptly gets chitin derivativ nanorize particle.
Controlled micro crystallization:
1. crystallite chitin: with highly purified chitin fragment by 1: 5-10 (W/V) adds 2N hydrochloric acid, temperature (95 ℃ of ∽) 1-2 hour keeps closely boiling, extremely neutral behind the remaining hydrochloric acid of elimination with running water rinsing chitin sediment, add about 50 times deionized water suspended sediment, smash the pastel of even sediment with the shearing homogeneous method of 20000rpm again to stable (not separating out Yu Shui).Reach in microscopically discriminating distribution of particles＜below the 30 μ M.
2. crystallite chitin: highly purified chitin is mixed with the aqueous solution of 1-5% concentration with acetate by 4: 1 (W/W), and the limit adds 2N sodium hydroxide solution limit and smashes into uniform and stable pastel with the shearing homogeneous method of 20000rpm, makes PH reach 6.5-7.5.
2. the cooperation technology of metal ion
1. take by weighing a certain amount of chitin derivativ nanorize or controlled micro crystallization powder, or measure the chitin derivativ nanorize or the controlled micro crystallization suspension of known content (concentration), corresponding concentration is adapted to 0.5-2.5%. zinc sulphate, copper sulphate, silver nitrate is mixed with 0.1M (mole) concentration respectively with deionized water.
2. by the 0.1M solution of following mol ratio slaine of dropping amount of calculation in the chitin derivativ particle suspension, stir simultaneously:
Composition chitin derivativ Zn Cu Ag-
Mole number (M) 1-4 0.1-16 0.1-1 0.01-0.1
Metal ion (salt) select for use can be independent a kind of also can two kinds of combinations or three kinds of combinations, in order to obtain the satisfied chelate of colour generation, should be with the component of zinc as necessity.
3. reactant liquor is warming up to 40-90 ℃, keeps heating and stirred simultaneously 3-5 hour. or remove by filter liquid phase (containing unreacted ion, impurity), clean, with absolute ethyl alcohol or acetone dehydration, vacuum drying, promptly get the product powder again with deionized water.
3. make all practicability preparations (formulation)
Spray:
Nanorize pulvis of the present invention and be very suitable for spraying and use through being micronized to the above controlled micro crystallization pulvis of 200-400 order is particularly suitable for moistening punishment of mucosal tissue focus or sterilization such as wound face, ulcer surface and oral cavity, throat, nasal cavity, vagina, anus.Also be suitable for disinfecting of body surface.In the application, preferably adopt the form of all types of sprayers.
Spray of the present invention can also be added following complementary composition except the chitin derivativ of carrying metal ion: as nanorize or micronized active carbon, zinc oxide, magnesia, titanium dioxide, silica, Chinese herbal medicine and extract, various adsorbents, astringent, resuscitation with aromatics, promoting blood circulation and removing blood stasis, aromatic essential oil such as borneol, Mentholum, Thymol, Lavender, Rosemary Oil, eucalyptus oil, caryophyllus oil, cinnamon oil.Antibiotic, bactericide, pain relieving sedative etc.
Cavernous body:
Get medical rank carboxymethyl chitosan, transfer the homogeneous solution that causes 1-3% concentration with deionized water.By carboxymethyl chitosan: the part by weight of nanorize or controlled micro crystallization powder=10: 0.1-5.0 fully mixes two-phase, vacuum outgas bubble back is expanded to 2-15mmd and freezes under-20 ℃ to-40 ℃ in mould, move to then in the freeze dryer and be lyophilized into sponge block through-40 ℃ to-80 ℃.
Also available other natural polymers of above-mentioned carboxymethyl chitosan, as hyaluronic acid, Jiao Yuan, gelatin, silk-fibroin, sodium alginate, carboxymethyl cellulose, polymerization lactic acid, choose any one kind of them or two kinds compound.Also can add synthesizing water-solubility macromolecules such as polyacrylic acid OVA, PVP, PEG in right amount, and glycerine, propane diols, polyalcohol etc. improve machinery, wetability, also can add the composition of above-mentioned spray in right amount.This cavernous body be suitable for stopping blooding first aid or operation nursing.
Stick with paste (cream) agent:
A: getting deacetylation is that 40-55% partly takes off acetyl, chitin that can be directly water-soluble and the powder chitin derivativ of carrying metal ion fully mixed to 1 ratio in 1 to 5: 5 and do not stir down deionization not or physiological saline, were mixed with paste (cream) agent that total solid matters reaches 2-20% by the denseness requirement.
B: get highly purified β-chitin (cuttlefish cartilage), flooded 24 hours through 60 ℃ of temperature of 45% sodium hydroxide, behind the clean surplus alkali (the sampling deacetylation is 76%), drop into deionized water by 1: 20 (W/V), shearing homogeneous method with 20000rpm behind the acetate of interpolation chitin 20% breaks into pastel, cleans to PH ∽ 6.5.Reach the average grain diameter of 50 microns of ∽ through microscopic.Pastel is freezed back squeezing remove adsorption moisture, vacuum drying gets β-chitin powder.During (2%) 20 ℃ of viscosity: 560cps).
The controlled micro crystallization powder chitin derivativ of above-mentioned powder and carrying metal ion fully mixed to 1 ratio in 1 to 5: 5 shear under the homogeneous, be made into paste (cream) agent of 2-20% concentration by the denseness requirement with deionized water or physiological saline.Except two class chitin derivativs, also can select, add all constituents of mentioning in the making of above-mentioned spray and cavernous body in right amount.
This paste (cream) agent is suitable for burn and scald and mucocutaneous ulcer, and hemorrhagic wound mouth is used, be specially adapted to depression (hole shape) property and large-area wound ulcer wound, have the preserving moisture of good stretchability, filling, film forming and film, gas permeability, pathogene and press down and kill and shielding.Have multi-efficiencies such as antibiotic, anti-inflammatory, hemostasis, pain relieving, promotion healing.Generally use after debridement, need not to take off and change, slough with the scab piece healing back.
The preparation of embodiment 1. G system candida albicans infection disease
Think, the common property and the recurrent trend of this disease are serious day by day, it is the exemplary of modern medical service " abuse ", special in heavy dose of controversies in hormone replacement in the elderly, and antibiotic, diet is unbalance, special common decline or the imbalance that causes " drug resistance sudden change " bacterium pearl and human immunity defense mechanism with scarce zinc is in close relations.Crowd's candida albicans infection outbreak position is mainly as oral cavity (thrush) and vagina mucosal tissues such as (doubt and be a class of venereal disease).Show various types of inflammation, as eczema, fester, papule, bubble or canescence film, produce secretion and itch pain etc.
Adopting a kind of spraying pulvis of the present invention in conjunction with the chitin acid solution 30 cases to be punished through about two weeks treatment (every month once) can heal entirely.80% (totally 24) were not recurred in 6 months.Sprayer formulation is as follows:
Component content
1. sprayer formulation:
Controlled micro crystallization chitin-Zn, Cu, Ag mol ratio:
(CH＝Zn、Cu、Ag＝10∶10∶2∶1) 30
β-chitin controlled micro crystallization powder 35
Zinc oxide 25
Thymol 5
Quaternary ammonium salt 5
The chitin acetic acid solution: chitin 2-5% contains acetate 10-25%
2. using method: dip in absorbent cotton or crumpled gauze and to get an amount of chitin acetic acid solution coating ulcer surface, extremely topped fully toward 1-2 the spray of ulcer surface sprayed coating that apply again after several minutes.Once a day, average two weeks can heal entirely.Still have the recidivist, recover the topical application of drug a few days and can calm down.
Embodiment 2. is the sore powder more
Make the compound controlled micro crystallization powder of shitosan AgZnCu by technology of the present invention, the mol ratio of shitosan, Ag, Zn, Cu is 20: 1: 10: 2.Add the powder of every active component by following percentage, through fully mix, efflorescence becomes the even pulvis of 100-200 purpose, promptly get this sore powder of healing.
Percentage composition (%)
Chitosan lactate (100-120 order) 35
Chitosan iodine compound (the 100-120 order contains iodine 20%) 10
Shitosan AgZnCu compound (120 order) 10
ZnO, TiO2 powder 10+10=20
Cysteine powder 2.5
V-C, alpha-lipoic acid powder 0.5+0.5=1.0
V-C, V-E (giving elder generation and chitosan lactate powder mixing) 2.5+2.5=5.0
OPC (pine bark source) 3.5
Thymol powder 3.0
Borneol powder 5.0
Allantoin powder 5.0
Above-mentioned pulvis spray (or spreading) is spread on the depression ulcer cave of diabetes patient or the chronic disunion ulcer of varication patient shank place's open sore part or mashed pin, once a day or the next day once.Most cases in the early stage of pyogenic infection of skin of can shrinking back gradually in 2-8 week, reduce and ooze out or fester, to grow new granulation tissue complete to incrustation.
The clinical observation of embodiment 3. burn and scald paints
Sticking with paste (cream) agent according to technology of the present invention makes (3.B) method, makes and contain β-shitosan and carry silver-colored shitosan (shitosan is 5: 1 with the mol ratio of silver) controlled micro crystallization powder, the weight ratio of two kinds of chitin derivativs is 1: 1, concentration is 7%, and has added the mixed essential oil (being eucalyptus oil, Thymol, each five equilibrium of rosemary oil) of 3.5% glycerine and 1.5%.Fully mix pastel.
Select shallow II ° and the dark II ° of surface of a wound 42 examples, burn surface area 8%-865.The position comprises face, four limbs, chest, abdomen, shank, each one of trunk.Positive controls: flamazine paint.
The result:
1. the shallow II ° of surface of a wound forms epithelium after 8-10 hour after being coated with this paste (cream) agent, protected the surface of a wound, causes wound fluid and reduces, and it is comfortable that patient feels, pain is eliminated, healing in average 8.2 days, and the diaphragm of formation comes off voluntarily.
The news rapid-curing cutback is dry behind the dark II ° of surface of a wound coating, forms diaphragm, not painful, nonirritant, healing in average 20.4 days.
Contrast 1 group: expose not coating merely.
Shallow II ° sepage is many, pain, about 2 days dryings, healing in average 10 days.About 1/5 case has low-grade infection.Healing after repeatedly changing dressings.
Dark II ° of surface of a wound idol has infection, The average healing 26.1 days.
Contrast 2 groups: the flamazine paint.
Shallow II ° need are coating repeatedly, oozes out in average 1.2 days to stop, and does not have and infects, healing in average 10.3 days
Easily become scab behind the dark II ° of surface of a wound coating, surface of a wound blackening does not have and infects, but healing time delays, and average 26.5 days, indivedual cases had eczematoid reaction.
Useful paste (cream) agent case all do not find the toxic reaction and the cutaneous anaphylaxis of liver, kidney, blood system.
3. bacteriology checking: before the paint behind (medicament) and the coating (skin sampling) bacterial culture all do not have bacterial growth.
4.10 42 positions of routine case are to the back surface of a wound water-permeable and air permeable function observed result of filming: burn the 1st in 24 hours.The surface of a wound is bigger approximately 10 times than normal skin loss of moist, films the surface of a wound then than the big approximately 2-6 of normal skin doubly.Filming, pad pasting is than the big approximately 2-3 of normal skin loss of moist times again for the surface of a wound, and the water evaporates after filming obviously reduces than filming.The surface of a wound has kept temperature, humidity, is beneficial to the growth of cell.
Illustrate:
1.. the silver content of positive controls " flamazine " paint reaches %, and being much higher than paint of the present invention and its major defect is that coated face is coke black, hinders the observation to the wound healing process.In addition,, positive controls is slightly less than paint of the present invention, to comprehensive comparison of two class healing speed, still not as good as paint of the present invention though infecting occurrence probability.
2.. this paint is easy to form transparent diaphragm at the surface of a wound, and as seen the healing process of wound analyses clearly.This paste still can increase the carrying capacity of Ag, Zn, Cu or add many reinforcements or the modification factor makes function more become perfect.
Embodiment 4. prevents halitosis and oral inflammation gargarism
It is that little ecological degeneration is relevant that halitosis and oral inflammation and immunodeficiency, nutrient imbalance, sanitary condition etc. cause oral cavity and digestion.This gargarism has the harmful pathogen (comprising mutans streptococcus, anaerobic bacteria and Candida albicans) of the immunologic function of promotion, tissue repair and inhibition, and double action reduces inflammation.Desorption to pathogene is especially effective, but beneficial flora is not produced inhibition.
Prescription is as follows:
Prescription element: percentage concentration (%)
Shitosan-Ag, Zn compound (annotating-1) 0.1-0.25
The plain Saccharoascorbic acid salt of shell (annotating-2) 0.30
Essential oil (branch mixtures such as Mentholum, eucalyptus oil, cinnamon oil, wintergreen) 0.25
OPC 1.0
Allantoin 0.3
Glycerine 10.0
Mannitol or xylitol 10.0
Ethanol 8.0
Deionized water → 100
Annotate-1: the oligosaccharide of shitosan molecular weight-5000D in the compound, the mol ratio of sugar, silver, zinc is 10: 0.1: 5.
Annotate-2: shitosan is same as described above.Chitosan powder (80 order) and equivalent ascorbic acid are fully ground well the back to add in the 40-50% ethanol and stirred 3 hours.Remove unnecessary ascorbic acid with 75% ethanol, absolute ethyl alcohol, vacuum drying.
Claims (6)
1. the manufacturing process of the multi-element metal complex antimicrobials that generates through chelatropic reaction of a shitosan and Ag, Zn, Cu and the prescription and the manufacturing process of external application agent.
2. according to claim 1. shitosan and Ag, Zn, Cu, the multi-element metal complex antimicrobials that chelatropic reaction generates, its characteristics are: on the one hand, it is that " green " is friendly to human body and ecosystem biotic population and environment thereof; On the other hand, it has satisfied killing effect to most of pathogene.Shitosan had excites immunity, promote the animal and plant cells growth, repair, remove toxin, hemostasis, slowly-releasing effect through and, the essential trace element physiological function of Zn, Cu, Ag ion obtained integration in the present invention.This integration makes the range of application of shitosan multi-element metal complex antimicrobials of the present invention obtain the expansion of big spoke degree.
According to claim 1. use this complex antimicrobials in manufacturing be suitable for wound, escort, environmental protection, the disaster relief, military affairs, mine disaster, daily life, industrial all kinds of practicalities " green " antibacterial product and articles for use.
4. according to claim 1.2.3, the characteristics of the present invention unit metal composite antibacterial agent also comprise: 1.. overcome the colour generation drawback of general silver-colored agent; 2.. be used to make nanoscale, the crystallite level also can be made the solution from colourless, transparent to various shallow beautiful color and lusters from the powder of 10 μ M-1 μ M, paste, paint, spray, film, sponge block etc.; 3.. can add various functional auxiliary elements, as Chinese herbal medicine extract, anodyne, vitamin, trace element, amino acids, polypeptide class, essential oil, wetting agent, humectant, antibiotic, bactericide.
5. the molecular weight according to shitosan in claim 1.2 shitosan Ag of the present invention, Zn, the Cu complex antimicrobials is 2000-100,0000D is preferably 3000-10,0000D, be preferably 3000-50,000D, deacetylation＞80%, be preferably＞90%, the gram molecule of shitosan and Ag, Zn, Cu (mole) is than being: (1-4): (0.1-16): (0.1-10) (0.01-1); Being preferably: (2-4): (1-2): (1-2): (0.5-1). the acid of dissolving shitosan Ag, Zn, Cu compound can be ascorbic acid, salicylic acid, benzoic acid, first, second, third, butyric acid, lactic acid or the like.
The preparation of the embodiment of the invention 1,2,3,4, middle You Guan G system candida albicans infection, more create powder, burn and scald paint and prevent and treat halitosis and the prescription of oral inflammation gargarism and preparation, be characterized in all having adopted shitosan-Ag, Zn, Cu or shitosan-Ag or shitosan-Ag, Zn complex, also adopted mixed essential oil and antioxidant OPC or vitamin-E, C etc.
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| CNA2005101148079A CN1965650A (en) | 2005-11-14 | 2005-11-14 | Multiple metal ion chelated green antibacterial agent of chitosan |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2005101148079A CN1965650A (en) | 2005-11-14 | 2005-11-14 | Multiple metal ion chelated green antibacterial agent of chitosan |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104145993A (en) * | 2014-08-04 | 2014-11-19 | 太原理工大学 | Method for preparing complex antimicrobial agent by blending chitosan and silver copper |
| WO2017161113A1 (en) * | 2016-03-16 | 2017-09-21 | Synedgen, Inc. | Compositions and methods of their use |
| CN107510857A (en) * | 2017-08-18 | 2017-12-26 | 东莞星美新新材料科技有限公司 | Antibacterial deodorant |
| CN111560160A (en) * | 2019-06-11 | 2020-08-21 | 南京林业大学 | Antibacterial unsaturated polyester resin adhesive and preparation method thereof |
| CN115583710A (en) * | 2022-07-19 | 2023-01-10 | 江苏驰佳环保科技有限公司 | A kind of chelating agent and preparation method thereof |
| US11717532B2 (en) | 2010-04-06 | 2023-08-08 | Synedgen, Inc. | Methods and compositions for treating wounds utilizing chitosan compounds |
| US11975018B2 (en) | 2012-09-20 | 2024-05-07 | Synedgen, Inc. | Methods for treatment or prevention of damage resulting from radiation, trauma or shock |
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2005
- 2005-11-14 CN CNA2005101148079A patent/CN1965650A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11717532B2 (en) | 2010-04-06 | 2023-08-08 | Synedgen, Inc. | Methods and compositions for treating wounds utilizing chitosan compounds |
| US11975018B2 (en) | 2012-09-20 | 2024-05-07 | Synedgen, Inc. | Methods for treatment or prevention of damage resulting from radiation, trauma or shock |
| CN104145993A (en) * | 2014-08-04 | 2014-11-19 | 太原理工大学 | Method for preparing complex antimicrobial agent by blending chitosan and silver copper |
| CN104145993B (en) * | 2014-08-04 | 2016-07-27 | 太原理工大学 | A kind of chitosan and silver-bearing copper are blended the method preparing complex antimicrobials |
| WO2017161113A1 (en) * | 2016-03-16 | 2017-09-21 | Synedgen, Inc. | Compositions and methods of their use |
| CN107510857A (en) * | 2017-08-18 | 2017-12-26 | 东莞星美新新材料科技有限公司 | Antibacterial deodorant |
| CN111560160A (en) * | 2019-06-11 | 2020-08-21 | 南京林业大学 | Antibacterial unsaturated polyester resin adhesive and preparation method thereof |
| CN115583710A (en) * | 2022-07-19 | 2023-01-10 | 江苏驰佳环保科技有限公司 | A kind of chelating agent and preparation method thereof |
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