CN1951482A

CN1951482A - Chinese medicinal preparation for treating apoplexy sequelae

Info

Publication number: CN1951482A
Application number: CNA200610114547XA
Authority: CN
Inventors: 王信锁
Original assignee: Individual
Current assignee: BEIJING WANSHOUTONG PHARMACEUTICAL TECHNOLOGY CORP
Priority date: 2006-11-15
Filing date: 2006-11-15
Publication date: 2007-04-25
Anticipated expiration: 2026-11-15
Also published as: CN100473410C

Abstract

The invention relates to a traditional Chinese medicinal composition for treating sequelae of apoplexy, which is prepared from raw materials of tortoise shell, raw astragalus root, batryticated silkworm, Chinese angelica root, Ligusticum wallichii, radix paeoniae rubrathe, earthworm, tabasheer, notoginseng, leeches, buthus martensi kirsch and senega root.

Description

A kind of Chinese medicine preparation for the treatment of apoplexy sequela

Technical field

The present invention relates to a kind of Chinese medicine preparation for the treatment of apoplexy sequela, is that a kind of apoplexy sequela for the treatment of is the Chinese medicine preparation of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.

Background technology

Acute cerebrovascular disease is a kind of non-traumatic cerebral local blood circulation obstacle that causes owing to various vascular reasons, one group of disease of focal nervous lesion occurs.Claim apoplexy, apoplexy again.Acute cerebrovascular disease is divided into hemorrhagic and ischemic two big classes according to the etiology and pathology difference clinically.Its sickness rate, disability rate, mortality rate, relapse rate are all very high, and existing data points out that apoplexy is first killer in various countries' cause of death first six digits major disease.1986～nineteen ninety of China is to ten thousand population cerebrovascular morbidity surveys surplus national seven big cities 600, average 215.8/10 ten thousand populations of sickness rate, apoplexy relapse rate 26%.Age and morbidity, being proportionate property of death, the death from cerebral hemorrhage rate is far above cerebral infarction.

Acute cerebrovascular disease belongs to disease categories such as Chinese medicine " apoplexy ", " sudden syncope ", " emotional syncope ", " hemiplegia ", " apoplexy ", " hemiplegia ".Nowadays alleged apoplexy is defined as: " apoplexy is on the basis of QI and blood interior-deficiency; meet the overstrain internal injury, be worried angry, have a liking for inducements such as food savoury, tobacco and wine; and then cause the internal organs imbalance of YIN and YANG; QI and blood is disorderly contrary, and the criminal's of flinging brain forms outside resistance of brain BI-syndrome involved the blood vessels or the blood oozing from the body openings or subcuta neous tissue brain feeling pulse; be primary symptom with the stuttering puckery or aphasia of unexpected confused servant, hemiplegia, facial hemiparalysis, speech, hemianesthesia clinically; and have onset anxious, change fast, as the characteristics that ailment said due to cold or exposure benefaction number becomes, good sending out in a kind of commonly encountered diseases of person in middle and old age.Be divided into hemorrhage apoplexy and ischemia apoplexy by characteristic of disease.”

Western medicine thinks that the factor of acute cerebrovascular disease is varied, and factor that blood vessel wall pathological changes factor, hemodynamics factor, blood constituent change, hemorheological factors etc. are arranged.Though the hypertension modal reason that is cerebral hemorrhage, its pathogenesis still has arguement so far, and simple hypertension is unlikely to cause angiorrhexis, but on the basis of vascular lesion due to the hypertension.The modal cause of disease of cerebral thrombosis is an atherosclerosis, and often with hypertension, rare reason has the inflammation of arterial wall, as tuberculosis, syphilis, suppurative, leptospiral infection, connective tissue disease, allergy arteritis etc., be also shown in congenital vascular malformation, polycythemia vera, blood hypercoagulability etc.

Cerebral hemorrhage, this class acute cerebrovascular disease of cerebral infarction, its sickness rate, case fatality rate, disability rate, relapse rate are still high, this means that Chinese and western medicine lacks effective measures to the treatment of acute cerebrovascular disease.Key is an active prevention, early discovery, early treatment.

Summary of the invention

The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of apoplexy sequela.Have determined curative effect, safe ready, little, the cheap characteristics of side effect.

The present invention is made by the following weight proportion raw material:

1.5～6 parts of 2.5～10 parts of Radix Paeoniae Rubra of 2.5～10 parts of Radix Astragali of vinegar Carapax Et Plastrum Testudinis

1～4 part of 1.5～6 parts of Pheretima of 1.5～6 parts of Radix Angelicae Sinensis (processed with wine) of Bombyx Batryticatus

0.1～1 part of 1～4 portion of Radix Notoginseng of 1.5～6 parts of Concretio Silicea Bambusaes of prepared RHIZOMA CHUAN XIONG with yellow rice wine

0.1～2 part of 0.1～1 portion of Scorpio of 0.1～2 portion of Hirudo of Radix Polygalae (processed)

The weight proportion of each raw material of optimization formula of the present invention is:

2.5～3.5 parts of 3～7 parts of Radix Paeoniae Rubra of 3～7 parts of Radix Astragali of vinegar Carapax Et Plastrum Testudinis

1.5～2.5 parts of 2.5～3.5 parts of Pheretimas of 2.5～3.5 parts of Radix Angelicae Sinensis (processed with wine) of Bombyx Batryticatus

0.3～0.7 part of 1.5～2.5 portions of Radix Notoginseng of 2.5～3.5 parts of Concretio Silicea Bambusaes of prepared RHIZOMA CHUAN XIONG with yellow rice wine

0.5～1.5 part of 0.3～0.7 portion of Scorpio of 0.5～1.5 portion of Hirudo of Radix Polygalae (processed)

The weight proportion of each raw material of optimum formula of the present invention is:

3 parts of 5 parts of Radix Paeoniae Rubra of 5 parts of Radix Astragali of vinegar Carapax Et Plastrum Testudinis

2 parts of 3 parts of Pheretimas of 3 parts of Radix Angelicae Sinensis (processed with wine) of Bombyx Batryticatus

0.5 part of 2 portions of Radix Notoginseng of 3 parts of Concretio Silicea Bambusaes of prepared RHIZOMA CHUAN XIONG with yellow rice wine

1 part of 0.5 portion of Scorpio of 1 portion of Hirudo of Radix Polygalae (processed)

Drug action mechanism among the present invention is as follows:

Vinegar Carapax Et Plastrum Testudinis nature and flavor are salty, sweet, are slightly cold.Return liver, kidney, heart channel.Has nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, the effect of the reinforcing the heart of nourishing blood.Can treat deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat is had a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, and the muscles and bones flaccidity is soft, and it is forgetful to have a guilty conscience etc.(the 143rd page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

The Radix Astragali nature and flavor are sweet, warm.Return lung, spleen channel.Have benefit and defend consolidating superficial resistance, inducing diuresis to remove edema, poison holding, the effect of granulation promoting.That can treat that internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, metrorrhagia and leukorrhagia, spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle do not burst or burst does not hold back and the disease of all weakness of QI blood deficiency etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1074th page).

Bombyx Batryticatus nature and flavor suffering is salty, flat.Return liver, lung, stomach warp.Effect with expelling wind to relieve convulsion, dissipating phlegm and resolving masses.Can treat apoplectic aphasia, infantile convulsion, wind syndrome of head, acute throat trouble, sore throat, scrofula tuberculosis, wind skin ulcer urticaria, erysipelas, mastitis etc.(" Chinese medicine voluminous dictionary " the 739th page).

The Radix Angelicae Sinensis (processed with wine) nature and flavor are sweet, hot, warm.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation.Can be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea stimulates the menstrual flow, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, traumatic injury, ulcer sores etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 553rd page).

Prepared RHIZOMA CHUAN XIONG with yellow rice wine nature and flavor suffering, perfume (or spice).Return liver, gallbladder, pericardium channel.Has blood-activating and qi-promoting, the effect of wind-expelling pain-stopping.Can treat menoxenia, amenorrhea dysmenorrhea, difficult labour, lump in the abdomen stomachache, the twinge of the breast side of body, arthralgia due to cold clonic spasm of the muscle, tumbling and swelling, headache due to pathogenic wind-heat, rheumatic arthralgia, skin infection swells and ache, placenta retention, cerebral ischemia, coronary heart disease, angina pectoris, atherosclerosis, hypertension, leukopenia due to the radiotherapy, chemotherapy, juvenile myopia, vitamin e deficiency, flu is dizzy, external plug nose treating malaria disease etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 171st page).

Radix Paeoniae Rubra nature and flavor suffering, hardship, flavor are trembled with fear.Return Liver Channel.Has clearing away heat and cooling blood, the effect of eliminating stasis to stop pain.Can treat maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, traumatic injury, carbuncle skin infection etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 659th page).

The Pheretima nature and flavor are salty, cold.Go into liver, spleen, lung, urinary bladder channel.Have heat clearing away, suppressing the hyperactive liver, Zhichuan, collateral dredging diuretic effect.Cure mainly high fanatical dry, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pant, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection, hyperpyrexia, bronchial asthma, hypertension, psychosis, ulcer of the lower limb, eczema, erysipelas, burn and scald, fracture etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 522nd page).

The Concretio Silicea Bambusae nature and flavor are sweet, and are cold.GUIXIN, Liver Channel.Has clear heat and eliminate phlegm, the effect of cool heart arresting convulsion.Can treat the calentura coma, middle wind-phlegm fan, the hot infantile convulsion of children's's expectorant, tic, night cry etc.(the 43rd page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

Sweet, the little hardship of Radix Notoginseng nature and flavor, temperature.Return liver, stomach warp.Has the dissipating blood stasis hemostasis, the effect of subduing swelling and relieving pain.Can treat spitting of blood, haematemesis, epistaxis, have blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling and swelling etc.(the 10th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

The Hirudo nature and flavor are salty, bitter, and are flat; Slightly poisonous.Return Liver Channel.Has removing blood stasis, removing blood stasis, the effect of stimulating the menstrual flow.Ke Zhi Liao mass in the abdomen mass in the abdomen, blood stasis amenorrhea, injury from falling down etc.(the 63rd page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

Scorpio nature and flavor suffering, flat, poisonous.Return Liver Channel.Effect with endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Can treat that infantile convulsion, tic spasm, middle air port are askew, hemiplegia, tetanus disease, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 581st page).

Radix Polygalae (processed) nature and flavor hardship, suffering, temperature.GUIXIN, kidney, lung meridian.Have the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, the repercussive effect.Can treat insomnia and dreamful sleep, forgetful palpitation with fear, staring spells that disarmony between the heart and kidney causes, expectoration is not well, sore swollen toxin, breast swell and pain etc.(the 124th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with vinegar Carapax Et Plastrum Testudinis, Radix Astragali, Bombyx Batryticatus and Radix Angelicae Sinensis (processed with wine): with prepared RHIZOMA CHUAN XIONG with yellow rice wine, Radix Paeoniae Rubra, Pheretima, Concretio Silicea Bambusae, Radix Notoginseng and Hirudo is ministerial drug; With Scorpio and Radix Polygalae (processed) is adjuvant.All medicines are harmonious, and have the effect of benefiting QI for activating blood circulation, nourishing YIN for suppressing the hyperactive YANG, dissipating blood stasis collateral dredging, the Fructus Alpiniae Oxyphyllae of calming the nerves altogether.The treatment effect for the treatment of sequela of apoplexy is definite, and toxic and side effects is little, taking convenience.

Chinese medicine preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.

Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.

Preparation of the present invention, peroral dosage form preferably, as: tablet capsule agent, oral liquid, buccal tablet, granule, electuary, pill, powder, suspensoid, powder, solution, drop, drop pill.Preferred Chinese medicine preparation is capsule, tablet, granule.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment apoplexy sequela of the Chinese medicine of respectively distinguishing the flavor of, and does not have chemical sweeting agent, and is nontoxic to human body.Show that through animal acute toxicity experiment the animal of being tested does not see any toxic reaction, safety of medicine is reliable.

2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid, also contain various trace elements such as Saponin, plant sterol and calcium, be beneficial to absorption of human body, health invigorating, and taking convenience.

3, the present invention can treat apoplexy sequela effectively, and prevention of stroke also has better curative effect, has improved patient's life quality and the time greatly, and higher healing rehabilitation efficacy is arranged.

Further specify the therapeutic effect of medicine of the present invention below by the clinical practice example to the treatment apoplexy sequela.Effect for the treatment of sequela of apoplexy criterion (the 200th page of chief editor's " traditional Chinese medical science disease diagnosis and treatment standard and prescription are selected for use " People's Health Publisher's calendar year 2001 version such as Dai Shen).

1, cure symptom and sign and disappear, can live on one's own life substantially.

2, improvement symptom and sign take a turn for the better, the action of energy cane, or basic life can be taken care of oneself.

3, more symptom and sign no change.

For showing medicine of the present invention, as follows through clinical test results to treatment apoplexy sequela therapeutic effect; Treatment apoplexy sequela patient 36 examples, the age is 46～72 years old, male's 20 examples, women's 16 examples.Take embodiment 1 capsule, each 2-10 grain, every day three to four times, eliminating cold for resuscitation water send down, and take half an hour ante cibum.One month is a course of treatment, take continuously three the course of treatment observe the curative effect.Cure 19 examples and account for 52.7%, 15 examples that take a turn for the better account for 41.6%, and more 2 examples do not account for 5.5%, and total effective rate reaches more than 94%.After three course of therapy, symptoms such as patient's hemiplegia, facial hemiparalysis, slurred speech all have obvious change or recovery from illness.And patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.

The specific embodiment

Embodiment 1 capsule takes by weighing raw material by following weight:

Preparation method is to get the vinegar Carapax Et Plastrum Testudinis earlier, Bombyx Batryticatus, Radix Notoginseng, Hirudo and Scorpio drying are crushed to 120～200 order fine powders, get Radix Astragali again, Radix Paeoniae Rubra, Radix Angelicae Sinensis (processed with wine), Pheretima, prepared RHIZOMA CHUAN XIONG with yellow rice wine, Concretio Silicea Bambusae and Radix Polygalae (processed) decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, and reclaimed ethanol, when 50 degree～55 are spent, be concentrated into the clear paste of relative density 1.30～1.32, again with clear paste and vinegar Carapax Et Plastrum Testudinis, Bombyx Batryticatus, Radix Notoginseng, Hirudo and Scorpio fine powder mixing, drying is ground into fine powder, incapsulates.Adorn 0.3 gram for every, usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, one month is a course of treatment.

Embodiment 2 tablets take by weighing raw material by following weight:

Preparation method is to get the vinegar Carapax Et Plastrum Testudinis earlier, Bombyx Batryticatus, Radix Notoginseng, Hirudo and Scorpio drying are crushed to 120～200 order fine powders, get Radix Astragali again, Radix Paeoniae Rubra, Radix Angelicae Sinensis (processed with wine), Pheretima, prepared RHIZOMA CHUAN XIONG with yellow rice wine, Concretio Silicea Bambusae and Radix Polygalae (processed) decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, and reclaimed ethanol, when 50 degree～55 are spent, be concentrated into the clear paste of relative density 1.30～1.32, again with clear paste and vinegar Carapax Et Plastrum Testudinis, Bombyx Batryticatus, Radix Notoginseng, Hirudo and Scorpio fine powder mixing, drying is ground into fine powder, adds appropriate amount of starch, alcohol granulation, after the drying, add an amount of magnesium stearate, tabletting, sugar coating are promptly.Usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, one month is a course of treatment.

Embodiment 3 granules take by weighing raw material by following weight:

Preparation method is to get the vinegar Carapax Et Plastrum Testudinis earlier, Bombyx Batryticatus, Radix Notoginseng, Hirudo and Scorpio drying are crushed to 120～200 order fine powders, get Radix Astragali again, Radix Paeoniae Rubra, Radix Angelicae Sinensis (processed with wine), Pheretima, prepared RHIZOMA CHUAN XIONG with yellow rice wine, Concretio Silicea Bambusae and Radix Polygalae (processed) decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, again with clear paste and vinegar Carapax Et Plastrum Testudinis, Bombyx Batryticatus, Radix Notoginseng, Hirudo and Scorpio fine powder mixing, drying, be ground into fine powder, add an amount of sucrose and soluble starch, alcohol granulation, the pack of dry back is promptly.Usually half an hour ante cibum warm boiled water, one time 1～3 bag, three to four times on the one, one month is a course of treatment.

Claims

1, a kind of Chinese medicine preparation for the treatment of apoplexy sequela is characterized in that it is made by the following weight proportion raw material:

2, a kind of Chinese medicine preparation for the treatment of apoplexy sequela according to claim 1, wherein the weight proportion of each raw material is:

3, a kind of Chinese medicine preparation for the treatment of apoplexy sequela according to claim 1, wherein the weight proportion of each raw material is:

4, the Chinese medicine preparation of claim 1-3 is to be fit to medicinal various dosage forms.

5, the Chinese medicine preparation of claim 4 is tablet, capsule, oral liquid, buccal tablet, granule, electuary, pill, powder, suspensoid, powder, solution, drop, drop pill.

6, the Chinese medicine preparation of claim 4 is capsule, tablet, granule.