CN1943712B - A Chinese traditional medicinal composition for treatment of astriction and its preparation method - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating constipation in children. The composition is prepared from Cistanche Herba, Hemp Seed, Angelica, Ophiopogon japonicus, Fructus Citrus Fructus Citrus Fructus, Radix Fructus Radix (stir-fried), Scrophulariae Scrophulariae and Gardeniae according to a certain process. , which is suitable for functional constipation; meanwhile, the invention also discloses a preparation method of the traditional Chinese medicine composition.

Description

A kind of traditional Chinese medicine composition for treating constipation and preparation method thereof

technical field

The invention relates to a traditional Chinese medicine composition for treating functional constipation and a preparation method thereof, belonging to the field of traditional Chinese medicines.

Background technique

Constipation in children refers to abnormal dry and hard stools in infants and young children. Children with difficulty in defecation will cry and be disturbed by anal pain during defecation. Children who have been constipated for many days may also experience symptoms such as spirit, poor appetite, and abdominal distension. Constipation not only brings pain to children, but also brings great peace and trouble to parents. There are many reasons for constipation. Generally speaking, constipation is mainly related to feeding methods, quality and quantity of diet, defecation habits, digestion and absorption capacity of the gastrointestinal tract, abdominal muscle pressure, development and driving force of intestinal smooth muscle. Compared with breastfeeding, artificially fed infants are prone to constipation. This is because milk contains more calcium and casein, while the content of sugar and starch is relatively less. After ingestion, it is easy to form calcium soap and cause constipation. Irregular life has no training for infants. The habit of defecating on time can also easily cause constipation; some chronic diseases such as rickets, dermatomyositis, etc. lead to malnutrition and also cause constipation. Therefore, it is very necessary to explore a drug for treating constipation in children.

Contents of the invention

The object of the present invention is to provide a Chinese medicinal composition for treating constipation and a preparation method thereof.

The object of the invention is achieved through the following technical solutions:

The first is the composition of the prescription, including the following bulk drugs in parts by weight:

Cistanche 100-300 parts by weight 100-200 parts by weight of hemp seed 100-200 parts by weight of angelica

50-150 parts by weight of Ophiopogon japonicus 50-150 parts by weight of Citrus aurantium 50-150 parts by weight of radish seed (stir-fried)

Scrophulariaceae 50-150 parts by weight Gardenia 50-150 parts by weight

After further research, it was determined that its optimal composition was:

Cistanche 200 parts by weight 150 parts by weight of hemp seeds 150 parts by weight of angelica

100 parts by weight of Ophiopogon japonicus 100 parts by weight of Citrus aurantium 100 parts by weight of radish seed (stir-fried)

100 parts by weight of Radix Scrophulariae 100 parts by weight of Gardenia

With regard to this prescription, the invention thinks that it can be made into clinically required oral liquid, granules, tablets, and capsules. For this, the inventor has carried out technological research again. The process is as follows:

Take the raw material drug, add 10 times the amount of water and decoct twice, the first time for 2 hours, the second time for 1.5 hours, combine the decoction, filter, and concentrate the filtrate to a clear paste with a relative density of 1.20-1.25 (70-80°C) , let it cool, add ethanol to make the alcohol content to 65%, fully stir, let it stand, separate the supernatant, recover the ethanol until it has no alcohol smell, and get final product.

Detailed ways:

The medicine of the present invention is suitable for functional constipation. According to its functions and indications, the inventor has verified its pharmacodynamics from the aspects of laxative and laxative.

Drugs Chinese medicine for children with constipation, self-made.

Compound diphenoxylate tablet (constipating agent): produced by Wujin Pharmaceutical Factory in Wujin City, Jiangsu Province, specification 2.5mg/tablet.

Animals Kunming mice, weighing 18-22 g, of both sexes, were provided by the Experimental Animal Department of Peking University School of Medicine.

method

Effect of test 1 on the defecation of normal mice

40 normal mice, fasted for 6 hours, were randomly divided into 4 groups, 10 in each group, each group received high (8ml/kg), medium (4ml/kg) and low (2ml/kg) doses of Xiaoer Mitong Oral Liquid (respectively diluted to 10ml, the same below) and intragastric administration of normal saline. After the administration, the number of feces grains, the weight of feces, and the time of the first discharge of black stool were observed continuously for 7 hours after administration, and the differences in the above indicators of the animals in each group were compared by t test. .

The impact of table 1 on the defecation of normal mice (X ± s)

Note: P<0.05 compared with normal saline group.

Test 2 Antidiphenoxylate Inhibition of Intestinal Propulsion Test

Fifty mice of both sexes were randomly divided into 5 groups, 10 in each group, and fed continuously for 25 days according to the dosage design method. After 12 hours of fasting on the last day, group A received normal saline, and groups C, D and E received oral administration of low, medium and high doses of traditional Chinese medicine once, and after 20 minutes, groups B, C, D and E received 50 mg of diphenoxylate After 10 minutes, each group was gavaged with charcoal powder suspension at 0.1ml/10g. After 20 min, the mice were sacrificed and laparotomized, and the small intestines were taken, and the propulsion length of the charcoal powder and the total length of the small intestine were measured, and the propulsion mobility rate of the charcoal powder was calculated.

Ink propulsion rate = ink propulsion length (cm)/total length of small intestine (cm)×100%

Table 2 Anti-diphenoxylate inhibits intestinal propulsion effect

Note: Compared with diphenoxylate control group, P<0.05.

Embodiment one

[Prescription] Cistanche 200g Hemp Seed 150g Angelica 150g

Ophiopogon japonicus 100g Citrus aurantium 100g Raisin seeds (stir-fried) 100g

Scrophulariaceae 100g Gardenia 100g

[Preparation method] Take the raw material, add 10 times the amount of water and decoct twice, the first time is 2 hours, the second time is 1.5 hours, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.20-1.25 (70-80°C ) clear paste, let it cool, add ethanol to make the alcohol content 65%, fully stir, stand still, separate the supernatant, recycle the ethanol until there is no alcohol smell, add 100g of sucrose, 225g of honey, 3g of stevia, adjust the pH When the value reaches 5.0-7.0, add water to 1000ml, mix well, let it stand, filter, fill, sterilize, and get ready.

Embodiment two

[Prescription] Cistanche 400g Hemp Seed 300g Angelica 300g

Ophiopogon japonicus 200g Citrus aurantium 200g Raisin seeds (fried) 200g

Scrophulariaceae 200g Gardenia 200g

[Preparation method] Take the raw material, add 10 times the amount of water and decoct twice, the first time is 2 hours, the second time is 1.5 hours, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.20-1.25 (70-80°C ) clear paste, let it cool, add ethanol to make the alcohol content 65%, fully stir, stand still, separate the supernatant, recover the ethanol until there is no alcohol smell, concentrate to a relative density of 1.10 (60°C), and spray dry , add sucrose until the total amount is 1000g, and dry-press granules to obtain the product.

Claims (4)

1. Chinese medicine composition is characterized in that this Chinese medicine composition made by following raw material medicaments:

Herba Cistanches 100～300 weight portion Fructus Cannabiss 100～200 weight portion Radix Angelicae Sinensis 100～200 weight portions

Radix Ophiopogonis 50～150 weight portion Fructus Aurantiis, 50～150 weight portion Semen Raphani (parched), 50～150 weight portions

Radix Scrophulariae 50～150 weight portion Fructus Gardeniaes 50～150 weight portions

Preparation method is as follows:

Get crude drug, decoct with water 1-3 time, each 1-3 hour, collecting decoction filtered, it is 1.20～1.25 clear paste that filtrate is concentrated in the time of 70～80 ℃ relative density, puts coldly, adds ethanol and makes and contain the alcohol amount and be 60-70%, fully stirs, leave standstill, divide and get supernatant, reclaim ethanol to there not being the alcohol flavor, promptly.

2. Chinese medicine composition as claimed in claim 1 is characterized in that this Chinese medicine composition made by following bulk drugs:

Herba Cistanches 200 weight portion Fructus Cannabiss 150 weight portion Radix Angelicae Sinensis 150 weight portions

Radix Ophiopogonis 100 weight portion Fructus Aurantiis, 100 weight portion Semen Raphani (parched), 100 weight portions

Radix Scrophulariae 100 weight portion Fructus Gardeniaes 100 weight portions.

3. Chinese medicine composition as claimed in claim 1 is characterized in that said composition can be made into clinical required oral liquid, granule, tablet, capsule.

4. Chinese medicine composition as claimed in claim 1 is characterized in that preparation method is as follows: get crude drug, add 10 times of amounts of water and decoct secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction, filter, it is 1.20～1.25 clear paste that filtrate is concentrated in the time of 70～80 ℃ relative density, puts cold, add ethanol and make that to contain alcohol amount be 65%, fully stir, leave standstill, divide and get supernatant, reclaim ethanol to there not being the alcohol flavor, promptly.