CN1943625B - an oral disinfectant - Google Patents

Abstract

The invention belongs to the technical field of oral disinfection, and is a disinfection treatment solution for oral hygiene, which comprises the following components in weight percent: 0.1-1% of sweetener, 0.1-1% of Scutellaria baicalensis, 0.1-1% of dried alum, and 0.1% of honeysuckle ～1%, Vitamin E 0.1～1%, Metronidazole 0.1～0.5%, Amoxicillin 0.1～0.5%, Glycerol 1～3%, Ethanol 5～10% with concentration of 85% and the balance of distilled water; Scutellaria baicalensis, dried alum, and honeysuckle were crushed separately, passed through a 20-mesh sieve, and ethanol was added to the crushed product, soaked at 4°C for 48-72 hours, then filtered in a filter, and the filtrate was freeze-dried at 4°C to obtain an extract; Mix the above extract with the remaining components, add medical phosphoric acid to adjust the pH to 7.0-7.5, and finally pack and seal. Compared with other commercially available oral care products, the present invention has the advantages of good mouthfeel, non-toxic, non-irritating, non-coloring, good bactericidal effect and long action time, and the like.

Description

an oral disinfectant

technical field

The invention relates to the field of medicines for oral disinfection treatment.

technical background

The oral disinfectants currently used clinically mainly include: iodine, antibiotics, acids and bases or chlorhexidine. Iodide ion has a strong oxidation ability, but it is an unstable substance, and it is easy to produce color changes with other substances, and at the same time, precipitation occurs, and the disinfection and sterilization effect is also reduced. Antibiotics such as nitrofurazone have poor taste and are prone to bacteriostasis. Acid-base or chlorhexidine have high cost, low bactericidal efficiency, poor stability, toxic, corrosive or irritating odor, and have certain damage to oral mucosa, oral odor cannot be eliminated, and a large amount of water is required after disinfection Rinse, cause damage if swallowed. Therefore, people wish to have safe and stable professional oral cavity cleaning solution always.

Contents of the invention

The purpose of the present invention is to provide an oral disinfectant solution, which overcomes the disadvantages of unsafe use and poor stability of existing professional oral disinfectant cleaning solution products.

Oral disinfectant that the present invention proposes comprises the component of following percentage by weight:

Sweetener 0.1-1%, Scutellaria baicalensis 0.1-1%, Alum 0.1-1%, Honeysuckle 0.1-1%, Vitamin E 0.1-1%, Metronidazole 0.1-0.5%, Amoxicillin 0.1-0.5%, 1-3% of glycerol, 5-10% of 85% ethanol and the remainder of distilled water;

Scutellaria baicalensis, dried alum, and honeysuckle were crushed separately, passed through a 20-mesh sieve, and 85% ethanol was added to the crushed product, soaked at 4°C for 48-72 hours, then filtered in a filter, and the filtrate was freeze-dried at 4°C to obtain the extract ; Then mix the above extract with the remaining components, add medical phosphoric acid to adjust the pH to 7.0-7.5, and finally seal it in cans.

The above-mentioned sweetener can be licorice or sugar. When using licorice, it must be crushed first, passed through a 20-mesh sieve, then added with 85% ethanol, soaked at 4°C for 48-72 hours, then filtered in a filter, and the filtrate was freeze-dried at 4°C Extract, then mix with other combinations. Sugars are artificial or natural sugars such as dextrose and levulose.

Essence or emulsifying refined oils (such as sorbitan, asparton, cyclamate and saccharin) can also be added as flavoring agents. Other materials such as pigments, preservatives, colorants or bleaching agents may be combined as necessary.

In the disinfectant of the present invention, metronidazole and amoxicillin mainly play a bactericidal effect; vitamin E not only has antioxidant activity, but also has the effect of promoting local blood circulation and promoting the regeneration of mucosal epithelium; Radix Glycyrrhizae can prevent tartar formation (tartar, dental bacteria) Pylori plaque is one of the suitable living environments for Helicobacter pylori, which can cause recurrent oral ulcers), and also has anti-virus, anti-inflammatory, anti-lipid peroxidation, immune regulation and lysosome stabilization, which can effectively resist ulcers and Antispasmodic, antibacterial, relieving cough and expectorant, and forming sweetness; Scutellaria baicalensis has the functions of clearing away heat and dampness, purging fire and detoxification, stopping bleeding, cooling blood, and preventing miscarriage. Scholars at home and abroad have conducted a lot of research on it, and isolated about 40 kinds of flavonoids, which have a wide range of pharmacological effects, such as anti-oxidation, anti-inflammation, immune regulation, anti-tumor, nervous system protection, heart and brain. Vascular system, digestive system, etc. Recently, medical researchers from the United States and China Taiwan jointly extracted a new drug component OroxylinA from it, which can inhibit COX-2 activity and can resist arthritis, bacterial-induced septic shock, cerebrovascular stroke and myocardial infarction. Dry alum is formed after the alum stone Ahinite is refined to remove its crystal water, mainly containing potassium aluminum sulfate, has anti-inflammatory, astringent, and antiseptic effects, and has inhibitory effects on Mycobacterium tuberculosis, Staphylococcus aureus, Bacillus typhi, hemolytic streptococcus, and pneumococcus At the same time, it has a significant inhibitory effect on Candida albicans. When the dried alum is applied externally, a layer of medicine film can be formed to protect the wound surface. Honeysuckle has the functions of anti-pathogenic microorganisms, anti-inflammation, antipyretic, liver protection, anti-fertility, hemostasis, immune regulation, lowering blood fat, and central nervous system stimulation. Honeysuckle has a certain inhibitory effect on a variety of pathogenic bacteria. The ethanol and acetone extracts of honeysuckle stems and leaves can significantly inhibit the growth of fungi, and also have inhibitory effects on various viruses. Glycerol plays the role of reconciliation and moisturizing; ethanol plays the role of solvent; distilled water plays the role of dilution.

Compared with the existing oral disinfection cleaning solution, the present invention has the following advantages: (1) the disinfection and sterilization effect is remarkable, and the killing rate can reach 1 minute for Escherichia coli, Staphylococcus aureus, Candida albicans and Bacillus subtilis 100%. (2) Non-toxic, non-irritating, non-corrosive, and fragrant. (3) It has a wide range of applications and is suitable for oral disinfection and sterilization of people of all ages in various fields, especially for the removal of bad breath; (4) This product has stable chemical properties. After refrigerated for 1 hour, high-speed centrifugation at room temperature at 3000-20000rpm/10-30min, no precipitation and stratification occurred, at 37°C, the active ingredient decreased by ≤5% within 3 months, and the validity period was two years. (5) Spray administration is adopted, no need to wash with water, and it is convenient to carry. (6) Non-toxic, non-irritating, non-corrosive, even if swallowed by mistake, it will not cause adverse effects.

This oral disinfectant is a compound with good absorption, can effectively reach the oral mucosa, effectively penetrate dental plaque, and be effectively absorbed locally without causing damage to other organs, and finally achieve increased efficacy and stable result of increased sexuality. The disinfectant solution can greatly increase the concentration of the medicine covering the oral mucosa and gums, prolong the action time in the oral cavity, facilitate the exertion of the medicine effect, and reduce the occurrence of side effects.

The oral antiseptic solution of the present invention can also be compatible with various ingredients to produce multiple therapeutic effects, such as hormones, vaccines, etc., using different concentrations to achieve different therapeutic purposes. Such as: the disinfectant of the present invention is compatible with dexamethasone, has higher local anti-inflammatory activity and glucocorticoid receptor specificity, has significant anti-oral ulcers, periodontitis, dental caries, cleaning before and after oral surgery, etc. Relieve the symptoms and prevent the deterioration of the condition. Most of the patients have remission within 1 to 2 weeks.

Detailed ways

Each of the above examples was prepared as follows:

Glycyrrhizae, Huang Ling, dried alum, and honeysuckle of the above components are respectively crushed, passed through a 20-mesh sieve, and ethanol is added to these crushed objects, submerged completely, soaked at 4°C for 48-72 hours, and then filtered in a filter and freeze-dry the extract at 4°C.

Then mix the extract with other components according to the ratio, stir evenly, then add medical phosphoric acid to adjust the pH to 7.0-7.5, filter with a 2.0um double-layer sterile filter membrane, and store in a sealed jar.

In the above examples, if the sweetener is not licorice, but dextrose is used in example 2 and example 5, it can be directly mixed with other components.

Claims (2)

1. oral-cavity disinfectant is characterized in that comprising following components in weight percentage:

The ethanol 5～10% and the distilled water surplus of sweeting agent 0.1～1%, Radix Scutellariae 0.1～1%, dried Alumen 0.1～1%, Flos Lonicerae 0.1～1%, vitamin E 0.1～1%, metronidazole 0.1～0.5%, amoxicillin 0.1～0.5%, glycerol 1～3%, concentration 85%;

With Radix Scutellariae, dried Alumen, Flos Lonicerae pulverize separately, cross 20 mesh sieves, in ground product, add the ethanol of concentration 85% respectively, 4 ℃ were soaked 48～72 hours, filtered in filter then, respectively 4 ℃ of lyophilizing of filtrate were got extract; Again above-mentioned extract and remaining component are mixed, add medical phosphoric acid and regulate PH to 7.0～7.5, last canning sealing.

2. oral-cavity disinfectant according to claim 1, it is characterized in that: sweeting agent is Radix Glycyrrhizae or sugar, to pulverize earlier when using Radix Glycyrrhizae, cross 20 mesh sieves, the ethanol that adds concentration 85% again, 4 ℃ were soaked 48～72 hours, and filtered in filter then, 4 ℃ of lyophilizing of filtrate are got extract, mix with other component then.