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CN1711845A - Disinfectant for killing coronary virus - Google Patents

Disinfectant for killing coronary virus Download PDF

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Publication number
CN1711845A
CN1711845A CN 200410049735 CN200410049735A CN1711845A CN 1711845 A CN1711845 A CN 1711845A CN 200410049735 CN200410049735 CN 200410049735 CN 200410049735 A CN200410049735 A CN 200410049735A CN 1711845 A CN1711845 A CN 1711845A
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cpe
toxicity toxicity
disinfectant
sterilization
water
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Chinese (zh)
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殷生章
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Abstract

A disinfectant able to kill the coronavirus of SARS is the solution of ethane peroxoix acid composition in the ratio of 1:(2.5-6). It is diluted by water in the ratio of 1:(100-1000) before used.

Description

A kind of disinfectant of killing SARS pneumonia coronavirus
Technical field:
The present invention relates to a kind of disinfectant of killing SARS pneumonia coronavirus, this disinfectant is with proper proportion (1: 2.5---1: 6) the Peracetic acid complex solution of Zu Chenging, water is with 1 during use: the dilution proportion of 100---1000, the sterilization target is sprayed to soak, modes such as evaporation carry out disinfection, and can kill the coronavirus that causes the SARS pneumonia.
Background technology:
With hydrogen peroxide, Peracetic acid is the high stable compound system disinfectant of composition, is a kind of disinfectant that is mainly used in aspects such as hospital, public place, livestock-raising field, family, communal service, pollutant processing.Can effectively kill various common disease substances.
Hydrogen peroxide, Peracetic acid high stable composite disinfectant be last century the seventies along with the development of Auxiliaries Industry is overcoming former hydrogen peroxide or Peracetic acid as the deficiency of single-activity composition disinfectant and a kind of new disinfectant of developing.Because the development of various active medium auxiliary agents makes the system that originally can not stablize coexistence be achieved.For over ten years, along with the continuous intensification of research, the effectiveness of its killing microorganisms improves constantly, and also constantly prolong stationary phase, has become a kind of efficient, ripe practical product.
At present the main disinfectant manufacturing enterprise in North America and Europe all produces this series products, the system that the peroxide composite disinfectant combines each composition of Peracetic acid, hydrogen peroxide, surfactant, complexing agent and adhesive agent together with the chemically stable equilibrium principle.Its microbial killing ability is with the 4-6 of concentration Peracetic acid doubly, and the 3-5 of chlorine dioxide doubly fartherly surpasses traditional aldehydes, phenols, quaternary ammonium salts disinfectant.And stable storage uses back all degradeds in environment at normal temperatures, ecotope is not caused any pollution and infringement.
Along with succeeding in developing of this series products, its application is constantly expanded.Environmental Protection Agency is used for article surface sterilization in approval in 1989, after gradually approval be used for livestock and poultry and culture fishery, the purification sterilization of hospital and public place space disinfection, family disinfection, the vehicles and drinking-water system.Approval in 1996 is used for the sterilization that kidney oozes the equipment of washing and various catheters.The various countries, Europe have also ratified above every purposes gradually.Various specialty sterilizations during this product of world health organisation recommendations breaks out as eqpidemic disease, especially space and crust sterilization.
Universal disinfectant on the domestic market is many based on sterilization at present, and is relatively poor to microbial body killing actions such as virus, Chlamydias under conventional working concentration, has only passivation in other words.And domestic high effect disinfectants has only chlorine dioxide and one pack system peracetic acid soln, and pathogene and infection chain become again and become increasingly complex at present, and these disinfectants are difficult to satisfy market demand.
2003 at world wide, particularly the atypical pneumonia that takes place of China make develop have suppress and kill the effect of atypical pneumonia coronavirus disinfectant significant, seeks a kind of stable, efficient, side effect little, widely applicable have simultaneously suppress and kill that the atypical pneumonia coronavirus acts on disinfectant constituted content of the present invention.
Summary of the invention:
The invention provides a kind of is the disinfectant of main active ingredient with hydrogen peroxide, Peracetic acid compound.
The present invention also provides the new application of this disinfectant, that is: use this disinfectant inhibition and kill the atypical pneumonia coronavirus.
The present invention also provides the preparation method and the using method of this disinfectant.
The compound system that mainly consists of hydrogen peroxide and Peracetic acid composition of disinfectant of the present invention is represented as with structural formula: H 2O 2+ CH 3COOH and CH 3COOOH+H 2The oxidation coexistence equilibrium system of O, other consist of: non-ionic surface active agent (n=10-12), the cationic high-molecular thickener, macromolecular complexing agent (molecular weight 〉=4000), state amyldiacid peroxide, oxyquinoline, its surplus is a water.
Disinfectant of the present invention is preferably filled a prescription and is consisted of:
Hydrogen peroxide 25-30%
Glacial acetic acid 8-12%
Alkylol APEO 1-3%
Polyvinylpyrrolidone 3-5%
Disodium ethylene diamine tetraacetate (EDTA) 0.01-0.1%
State amyldiacid peroxide 2-4%
Oxyquinoline 0.3-0.5%
Its surplus is a water.
Above percentage is percentage by weight.
Disinfectant of the present invention is a multicomponent stable collaboration system.Optimal proportion (1: 5) according to Peracetic acid and hydrogen peroxide sensitive concentration (MBC) design separately.When concentration of hydrogen peroxide being increased to 5 times of Peracetic acid concentration, system can obtain the highest OR unit, and the oxidability effect basis of this class disinfectant just.
Disinfectant manufacturing step of the present invention is as follows:
The precision weighing raw material, main material hydrogen peroxide and glacial acetic acid mix stirring, add other raw materials, stop reaction, can, packing.
Concrete step can be: the raw material of hydrogen peroxide 25-30%, glacial acetic acid 8-12%, alkylol APEO 1-3%, polyvinylpyrrolidone 3-5%, disodium ethylene diamine tetraacetate (EDTA) 0.01-0.1% is mixed, react, add water to total amount, when the survey Peracetic acid is 4.5-5.5, add state amyldiacid peroxide 2-4%, oxyquinoline 0.3-0.5% mixes and gets final product.
It is fairly simple making principle, but the dynamic equilibrium of control reaction and the adding of various auxiliary compositions are very narrow " point " condition of a segment limit during the course, are slightly offset, and entire block is promptly scrapped.The technology core point is:
PH：2.20---2.75。
E 0=2.16V: add the reaction controlling agent.
E 0=2.18V: add surfactant and complexing agent.
C Ch 3Cooh/c H 2O 2During=1.0/4.75: lower the temperature and stop overall process.
The another one importance is the selection and the design of packaging material:
(1) will tolerate almost is the destruction of the highest chemicals of oxidizing potential.
(2) adapt to the course of reaction of dynamic equilibrium and higher vapour pressure, can arrange and release minimum gas, but must guarantee not trickle, and guarantee that gas is unidirectional release.Like this, just require strictly to select the PP of fixed member weight range and PE material to annotate the pressure pail pack,, and select semipermeable membrane outgas material with mechanics balance method design shape and angle radian.
The macromolecular complexing agent of the optimum weight that the present invention selects for use obtains can stablizing under the normal temperature product of storage, and the cationic high-molecular thickener that the present invention selects for use makes product use the back can retain 1-1.5 hour in the direct activity of crust;
When disinfectant of the present invention proves in 0.02% above concentration through the Guangdong Prov. Disease Prevention-control Center, can kill the SARS coronavirus; The big the 3rd attached clinical hospital infectious disease section experimental results show that hepatitis viruse when the 0.03% above concentration simultaneously, can kill hepatitis B fully.Disinfectant of the present invention can be killed various common pathogenic former in bacterium, fungi, virus and intractable brood cell such as bacillus anthracis in 0.002～1.0% concentration.
Major technique characteristics of the present invention are:
(1) compares with other all kinds of disinfectants, have the effectiveness of the strongest killing microorganisms.
Two kinds of active ingredients stably combine together, and reach more potent disinfective action.Release liquor ratio with what Peracetic acid content was equal to, the effect of compound system has improved 4-5 doubly.0.002-1.0% concentration can be killed various common pathogenic former in bacterium, fungi, virus and intractable brood cell such as bacillus anthracis.
(2) have spontaneous evaporation and permeability, can play a role to each dead angle;
(3) hydrogen peroxide, Peracetic acid content have best synergistic effect mutually under 5: 1 situation, can reduce the required time of pathogene of killing.
(4) fully prolong the holding time, the stable storage life of product was reached more than 1.5 years, overcome common Peracetic acid, hydrogen peroxide storage life and have only several days defectives to several weeks.
(5) be a kind of real environment-friendly type disinfectant, promptly be decomposed into water and oxygen oxygen etc. after effect is finished.Excitant to humans and animals is extremely low, does not produce carcinogenic substances such as chloroform, is self degradation when this product is had an effect, and need not secondary cleaning, also not to any infringement of environment structure.
The experimental study report that below has killing action for SARS-COV (SARS coronavirus) for disinfectant of the present invention
Experimental technique:
One, material:
1, A liquid: 5% disinfectant of the present invention is called: Europe for the gram, B liquid: 10% dichloroacetic acid in contrast:
2, aseptic standard hard water: hardness 342mg/L is used to dilute Europe for restraining and dichloroacetic acid:
3, dilution: the MEM of 2% calf serum:
4, cell: VeroE6;
5, virus: SARS-COV.
Two, method: micro-cytopathy political reform
1, the mark sudden strain of a muscle hard water with sterilization in advance dilutes 5% Europe successively for gram (A liquid):
1∶5→1∶10→1∶50→1∶100→1∶250→1∶500→1∶1000：
2, the standard hard water with sterilization in advance dilutes 10% dichloroacetic acid (B liquid) successively:
1：5→1∶10→1∶50→1∶100→1∶200
3, will dilute each good dilution Europe adds for gram or dichloroacetic acid 0.5ml
0.5mlSARS-COV, mixing effect 10min:
4, the aseptic hard water of virus control mixed liquor: 0.5ml adds 0.5mlSARS-COV, mixing effect 10min;
5, the MEM dilution 10 times of dilutions successively with 2% calf serum of the mixed liquor of gram or dichloroacetic acid and SARS-COV are replaced in Europe: 1: 10 -1→ 1: 10 -2→ 1: 10 -3→ 1: 10 -4→ 1: 10 -5The virus control dilution process is the same;
6, vitellophag according to a conventional method, preparation VeroE6 cell suspension, and cell suspension joined in the trace cell plate of aseptic 96 holes every hole 0.1ml;
7, will dilute good mixed liquor and join the 96 holes trace cell plate that added the VeroE6 cell every hole 0.1ml from high dilution to low dilution factor successively;
8, put 5%CO 236 ℃ of CO 2Incubator is cultivated.
Three, the result observes and analyzes:
1, plays observed result next day, when stable disease (CPE) appears in virus control, write down the result, cytotoxicity caused record " toxicity " occurs, cytopathy record " CPE-" do not occur, cytopathy occurs and be recorded as " CPE+ ";
Experimental result sees Table 1-7:
Experimental result summary sheet (1)
The experiment date: on October 11st, 2003
Date of observation: on October 16th, 2003
The result
A1 stoste 10 -1??10 -2??10 -3??10 -4??10 -5A2 stoste 10 -1??10 -2??10 -3??10 -4??10 -3 Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Do not find cytopathogenic effect behind 1: 5 dilution inactivation of viruses
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Do not find cytopathogenic effect behind 1: 10 dilution inactivation of viruses
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
Illustrate: A liquid is that gram is replaced in 5% Europe: dilute in following ratio with sterilization hard water successively
A1:1: 10 times of dilutions successively behind the 5 dilution .5ml+0.5mlSARS-COV effect 10min
A2:1: 10 times of dilutions successively after the 10 dilution 0.5ml+0.5mlSARS-COV effects 10
Experimental result summary sheet (2)
The experiment date: on October 11st, 2003
Date of observation: on October 16th, 2003
The result
A3 stoste 10 -1??10 -2??10 -3??10 -4??10 -5A4 stoste 10 -1??10 -2??10 -3??10 -4??10 -5 Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Do not find cytopathogenic effect behind 1: 50 dilution inactivation of viruses
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Do not find cytopathogenic effect behind 1: 100 dilution inactivation of viruses
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
Illustrate:
A3:1: 10 times of dilutions successively behind the 50 dilution .0.5ml+0.5mlSARS-COV effect 10min
A4:1: 10 times of dilutions successively after the 100 dilution 0.5ml+0.5mlSARS-COV effects 10
Experimental result summary sheet (3)
The experiment date: on October 11st, 2003
Date of observation: on October 16th, 2003
The result
A5 stoste 10 -1??10 -2??10 -3 Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Do not send out behind 1: 200 dilution inactivation of viruses
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??10 -4??10 -5V is to stoste 10 -1??10 -2??10 -3??10 -4??10 -5 ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- Existing cytopathogenic effect
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ The virus control titre is: 4.0log TCID50/ 100ul
??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+
??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+
??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+
??CPE+ ??CPE ??- ??CPE+ ??CPE ??- ??CPE ??- ??CPE+ ??CPE ???- ??CPE+
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
Illustrate:
A5:1: 10 times of dilutions successively behind the 200 dilution .0.5ml+0.5mlSARS-COV effect 10min
V (virus) contrast: 10 times of dilutions successively behind the sterilization hard water 0.5ml+0.5mlSARS-COV effect 10min
Experimental result summary sheet (4) 2
The experiment date: on October 11st, 2003
Date of observation: on October 16th, 2003
The result
B1 stoste 10 -1??10 -2??10 -3??10 -4??10 -5B2 stoste 10 -1??10 -2??10 -3??10 -4??10 -5 Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Do not find cytopathogenic effect behind 1: 10 dilution inactivation of viruses
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Do not find cytopathogenic effect behind 1: 20 dilution inactivation of viruses
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
Illustrate: B liquid is 10% dichloroacetic acid: dilute in following ratio with sterilization hard water successively
B1:1: 10 times of dilutions successively behind the 10 dilution .05ml+0.5mlSARS-COV effect 10min
B2:1: 10 times of dilution experiments summary sheet (5) as a result successively behind the 20 dilution 0.5ml+0.5mlSARS-COV effect 10min
The experiment date: on October 11st, 2003
Date of observation: on October 16th, 2003
The result
B3 stoste 10 -1??10 -2??10 -3??10 -4??10 -5B2 stoste 10 -1??10 -2??10 -3??10 -4??10 -5 Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Do not find cytopathogenic effect behind 1: 100 dilution inactivation of viruses
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Do not find cytopathogenic effect behind 1: 200 dilution inactivation of viruses
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
Illustrate:
B3:1: 10 times of dilutions successively behind the 100 dilution .0.5ml+0.5mlSARS-COV effect 10min
B4:1: 10 times of dilutions successively behind the 200 dilution 0.5ml+0.5mlSARS-COV effect 10min
Experimental result summary sheet (6) 2
The experiment date: on October 11st, 2003
Date of observation: on October 16th, 2003
The result
A6 stoste 10 -1??10 -2??10 -3??10 -4 Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity ??1∶250
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??10 -5A7 stoste 10 -1??10 -2??10 -3??10 -4??10 -5 ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity ??1∶500
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
Illustrate: A liquid is that gram is replaced in 5% Europe: dilute in following ratio with sterilization hard water successively
A6:1: 10 times of dilutions successively behind the 250 dilution .0.5ml+0.5mlSARS-COV effect 10min
A7:1: 10 times of dilutions successively behind the 500 dilution 0.5ml+0.5mlSARS-COV effect 10min
Experimental result summary sheet (7)
The experiment date: on October 11st, 2003
Date of observation: on October 16th, 2003
The result
A8 stoste 10 -1??10 -2??10 -3??10 -4??10 -5V is to stoste 10 -1??10 -2??10 -3??10 -4??10 -5 Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Behind 1: 1000 dilution inactivation of viruses in 10 -2The dilution row are found 2 porocyte pathologies (CPE+)
Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity Toxicity
??CPE ??- ??CPE+ ??CPE ??- ??CPE ??- ??CPE ??- ??CPE+ ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ The virus control titre is: 4.25log TCID50/ 100ul
??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+
??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+
??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+ ??CPE+
??CPE+ ??CPE ??- ??CPE+ ??CPE ??- ??CPE+ ??CPE+ ??CPE+ ??CPE+
??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??- ??CPE ??-
Illustrate:
A8:1: 10 times of dilution V (virus) contrast successively behind the 1000 dilution .0.5ml+0.5mlSARS-COV effect 10min: 10 times of dilutions successively behind the sterilization hard water 0.5ml+0.5mlSARS-COV effect 10min
Disinfectant of the present invention, main application is: be used as
(1) sudden on a large scale public health event sterilization;
(2) sterilization of station, high density crowd public place, airport and the various vehicles routinely;
(3) sterilization of specific (special) requirements place such as hospital and medical waste;
(4) customs imports and exports sterilizations such as vehicle;
(5) sterilization of drinking water source and water system;
(6) family's cupboard, defend space disinfection;
(7) sterilization on breed farm;
(8) mariculture sterilization;
(9) sterilization in sports apparatus and other consumer places;
(10) sterilization in office place, entertainment place etc.
Disinfectant of the present invention, quality control standard is:
Outward appearance: colourless clear liquid has foam and penetrating odor
Arsenic :≤10ppm (A 3 5+)
Heavy metal :≤5ppm
Stationary phase (T 90): 〉=1.5 years
Disinfectant of the present invention, using method is:
Water is with 1 during use: the dilution proportion of 100---1000, the sterilization target to be sprayed to soak, and modes such as evaporation carry out disinfection, and can kill the coronavirus that causes the SARS pneumonia.
Embodiment:
Further specify the present invention by the following examples.
Embodiment 1
Prescription is formed:
Hydrogen peroxide 25%
Glacial acetic acid 10%
Alkylol APEO 2%
Polyvinylpyrrolidone 4%
Disodium ethylene diamine tetraacetate (EDTA) 0.05%
State amyldiacid peroxide 3%
Oxyquinoline 0.4%
Its surplus is a water
Method for making:
The raw material of hydrogen peroxide, glacial acetic acid, alkylol APEO, polyvinylpyrrolidone, disodium ethylene diamine tetraacetate (EDTA) is mixed, react, add water, when the survey Peracetic acid is 4.5-5.5 to total amount, add state amyldiacid peroxide, oxyquinoline mixes and gets final product.
Embodiment 2
Prescription is formed:
Hydrogen peroxide 30%
Glacial acetic acid 10%
Alkylol APEO 2%
Polyvinylpyrrolidone 4%
Disodium ethylene diamine tetraacetate (EDTA) 0.05%
State amyldiacid peroxide 3%
Oxyquinoline 0.4%
Its surplus is a water
Method for making:
The raw material of hydrogen peroxide, glacial acetic acid, alkylol APEO, polyvinylpyrrolidone, disodium ethylene diamine tetraacetate (EDTA) is mixed, react, add water, when the survey Peracetic acid is 4.5-5.5 to total amount, add state amyldiacid peroxide, oxyquinoline mixes and gets final product.

Claims (10)

1. disinfectant, it consists of:
Hydrogen peroxide 25-30%;
Acetate 8-12%;
Non-ionic surface active agent 1-3%;
Cationic high-molecular thickener 3-5%;
Molecular weight 〉=4000 macromolecular complexing agent 0.01-0.1%;
State amyldiacid peroxide 2-4%;
Oxyquinoline 0.3-0.5%;
Surplus is a water.
2. the disinfectant of claim 1 is characterized in that, non-ionic surface active agent is the alkylol APEO.
3. the disinfectant of claim 1 is characterized in that, the cationic high-molecular thickener is a polyvinylpyrrolidone.
4. the disinfectant of claim 1 is characterized in that, molecular weight 〉=4000 macromolecular complexing agents are disodium ethylene diamine tetraacetate.
5. the preparation method of the disinfectant of claim 1, it is characterized in that, the raw material of hydrogen peroxide 25-30%, glacial acetic acid 8-12%, alkylol APEO 1-3%, polyvinylpyrrolidone 3-5%, disodium ethylene diamine tetraacetate (EDTA) 0.01-0.1% is mixed, react, add water to total amount, when the survey Peracetic acid is 4.5-5.5, add state amyldiacid peroxide 2-4%, oxyquinoline 0.3-0.5% mixes.
6. the disinfectant of claim 1 is used for suppressing and/or killing the atypical pneumonia coronavirus.
7. the disinfectant of claim 1 is as the Application of disinfectants that suppresses and/or kill the atypical pneumonia coronavirus.
8. the application of claim 7, the scope of application is:
(1) sudden on a large scale public health event sterilization;
(2) sterilization of station, high density crowd public place, airport and the various vehicles routinely;
(3) sterilization of specific (special) requirements place such as hospital and medical waste;
(4) customs imports and exports sterilizations such as vehicle;
(5) sterilization of drinking water source and water system;
(6) family's cupboard, defend space disinfection;
(7) sterilization on breed farm;
(8) mariculture sterilization;
(9) sterilization in sports apparatus and other consumer places;
(10) sterilization in office place, entertainment place etc.
9. the using method of the disinfectant of claim 1 is characterized in that, water is with 1 during use: the dilution proportion of 100---1000 carries out disinfection in the mode that is selected from immersion, sprinkling, evaporation to the sterilization target.
10. the disinfectant of claim 1, quality control standard is:
Outward appearance: colourless clear liquid has foam and penetrating odor
Arsenic :≤10ppm (A35+)
Heavy metal :≤5ppm
Stationary phase (T90): 〉=1.5 years.
CN 200410049735 2004-06-25 2004-06-25 Disinfectant for killing coronary virus Pending CN1711845A (en)

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Application Number Priority Date Filing Date Title
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Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 200410049735 CN1711845A (en) 2004-06-25 2004-06-25 Disinfectant for killing coronary virus

Publications (1)

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CN1711845A true CN1711845A (en) 2005-12-28

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103108643A (en) * 2010-01-22 2013-05-15 希普罗特克有限公司 Antimicrobial agents and methods of use
US8778387B2 (en) 2009-09-02 2014-07-15 Hyprotek, Inc. Antimicrobial medical dressings and protecting wounds and catheter sites
US9039967B2 (en) 2012-02-06 2015-05-26 Hyprotek, Inc. Antiseptic applicators and packaging techniques
CN106665570A (en) * 2016-12-20 2017-05-17 广东环凯微生物科技有限公司 Foam cleaning disinfectant containing peracetic acid and application of foam cleaning disinfectant
WO2017137408A1 (en) * 2016-02-12 2017-08-17 Mavena International Ag Disinfectant agent

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9789005B2 (en) 2009-09-02 2017-10-17 Hyprotek, Inc. Antimicrobial medical dressings and protecting wounds and catheter sites
US8778387B2 (en) 2009-09-02 2014-07-15 Hyprotek, Inc. Antimicrobial medical dressings and protecting wounds and catheter sites
US9253987B2 (en) 2010-01-22 2016-02-09 Hyprotek, Inc. Antimicrobial agents and methods of use
US8846008B2 (en) 2010-01-22 2014-09-30 Hyprotek, Inc. Antimicrobial agents and methods of use
CN103108643A (en) * 2010-01-22 2013-05-15 希普罗特克有限公司 Antimicrobial agents and methods of use
CN103108643B (en) * 2010-01-22 2016-10-26 希普罗特克有限公司 Comprise the antibacterial of peroxide, alcohol and chelating agen
US8846009B2 (en) 2010-01-22 2014-09-30 Hyprotek, Inc. Antimicrobial agents and methods of use
US9039967B2 (en) 2012-02-06 2015-05-26 Hyprotek, Inc. Antiseptic applicators and packaging techniques
US9192443B2 (en) 2012-02-06 2015-11-24 Hyprotek, Inc. Combined cap applicators
US10080620B2 (en) 2012-02-06 2018-09-25 Hyprotek, Inc. Portable medical device protectors
US10617472B2 (en) 2012-02-06 2020-04-14 Hyprotek, Inc. Adhesive patch with antimicrobial composition
WO2017137408A1 (en) * 2016-02-12 2017-08-17 Mavena International Ag Disinfectant agent
CN106665570A (en) * 2016-12-20 2017-05-17 广东环凯微生物科技有限公司 Foam cleaning disinfectant containing peracetic acid and application of foam cleaning disinfectant
CN106665570B (en) * 2016-12-20 2019-09-03 广东环凯微生物科技有限公司 A kind of foam cleaning disinfectant containing peracetic acid and application thereof

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