CN1608610A - A kind of preparation method of propolis concentrated mouthwash - Google Patents
A kind of preparation method of propolis concentrated mouthwash Download PDFInfo
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- CN1608610A CN1608610A CNA2003101019613A CN200310101961A CN1608610A CN 1608610 A CN1608610 A CN 1608610A CN A2003101019613 A CNA2003101019613 A CN A2003101019613A CN 200310101961 A CN200310101961 A CN 200310101961A CN 1608610 A CN1608610 A CN 1608610A
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- propolis
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- xylitol
- distilled water
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- 241000241413 Propolis Species 0.000 title claims description 21
- 229940069949 propolis Drugs 0.000 title claims description 21
- 238000002360 preparation method Methods 0.000 title claims description 12
- 239000002324 mouth wash Substances 0.000 title description 4
- 229940051866 mouthwash Drugs 0.000 title description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 17
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000000811 xylitol Substances 0.000 claims abstract description 17
- 235000010447 xylitol Nutrition 0.000 claims abstract description 17
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 17
- 229960002675 xylitol Drugs 0.000 claims abstract description 17
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 239000012153 distilled water Substances 0.000 claims description 15
- 239000002202 Polyethylene glycol Substances 0.000 claims description 13
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- 239000000203 mixture Substances 0.000 claims description 8
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- 238000003756 stirring Methods 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 4
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- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
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- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
(一)技术领域(1) Technical field
本发明涉及一种牙齿或口腔清洁剂的制备方法。具体的说是以蜂胶、木糖醇为主要成分制备的浓缩漱口剂。The invention relates to a preparation method of tooth or oral cavity cleaning agent. Specifically, the concentrated mouthwash is prepared with propolis and xylitol as main components.
(二)背景技术(2) Background technology
全国牙防组进行的第二次全国口腔健康流行病学抽样调查报告显示，我国82％的成年人有牙龈萎缩现象，而牙龈萎缩正是导致根部龋齿的元凶。龋齿是口腔科常见病，患龋率可达30％～95％。引起龋病的主要因素是细菌感染，在牙菌斑的菌群中，变形链球菌能在牙菌斑中进行无氧代谢，发酵产酸，成为龋病的主要致病菌。因此，抑制或杀灭牙菌斑中的变形链球菌成为防治龋病的关键。The second national oral health epidemiological sampling survey report conducted by the National Dental Prevention Group shows that 82% of adults in my country have gingival recession, and gingival recession is the culprit leading to root caries. Dental caries is a common disease in stomatology, and the caries rate can reach 30% to 95%. The main factor causing dental caries is bacterial infection. In the flora of dental plaque, Streptococcus mutans can perform anaerobic metabolism in dental plaque, ferment and produce acid, and become the main pathogenic bacteria of dental caries. Therefore, inhibiting or killing Streptococcus mutans in dental plaque has become the key to preventing and treating dental caries.
蜂胶是近年来研究较多的天然防龋物质，具有抗菌、抗氧化、抑酶、结合蛋白等生物学作用。已有许多研究证实，蜂胶能抑制或杀灭牙菌斑中的变形链球菌及其他厌氧菌，从而达到防治口腔疾病的目的。Propolis is a natural anti-caries substance that has been studied more in recent years. It has biological functions such as antibacterial, anti-oxidation, enzyme inhibition, and protein binding. Many studies have confirmed that propolis can inhibit or kill Streptococcus mutans and other anaerobic bacteria in dental plaque, so as to achieve the purpose of preventing and treating oral diseases.
木糖醇是一种可以从白桦树、橡树、玉米等植物中提取的天然甜味剂。上世纪六七十年代，芬兰科学家研究发现，木糖醇不会被蛀牙菌(变性链球菌)发酵而产生导致龋齿的酸性物质，它不能提供细菌赖以生存的营养，近年来还发现，木糖醇对早期的龋齿还有帮助其自然修复的作用。Xylitol is a natural sweetener that can be extracted from plants such as birch, oak, and corn. In the 1960s and 1970s, Finnish scientists found that xylitol would not be fermented by tooth-cavity bacteria (Streptococcus mutans) to produce acidic substances that cause dental caries, and it could not provide nutrients for bacteria to survive. Sugar alcohols also help the natural restoration of early caries.
本发明选用无毒、对口腔粘膜无刺激的天然保健食品配制而成。具有芳香爽口、清洁口腔、消除口臭、抗菌消炎、保护牙齿、防治口腔疾病，如牙龋炎、牙周炎、口腔炎、咽喉炎，其优点是使用简便、节省时间，而且不需特别用具，是一种非常有效的口腔清洁用品。The invention is prepared from natural health food which is non-toxic and non-irritating to oral mucosa. It is fragrant and refreshing, cleans the mouth, eliminates bad breath, antibacterial and anti-inflammatory, protects teeth, and prevents oral diseases, such as dental caries, periodontitis, stomatitis, and pharyngitis. Its advantages are easy to use, time-saving, and no special tools are needed. It is a very effective oral cleaning product.
(三)发明内容(3) Contents of the invention
本发明的技术解决方案是提供了一种蜂胶浓缩漱口剂的制备方法，该组合物含有下述重量份数的组分，The technical solution of the present invention is to provide a kind of preparation method of propolis concentrated mouthwash, and this composition contains the component of following parts by weight,
组分 重量份Components Parts by weight
蜂胶 0.5-8Propolis 0.5-8
木糖醇 5-15Xylitol 5-15
聚乙二醇 1-7Polyethylene glycol 1-7
丙二醇 10-70Propylene Glycol 10-70
配方中采用聚乙二醇可增加主药对口腔粘膜的穿透能力，使主药更好发挥疗效，丙二醇具有滋润溃疡面，粘附药物使药物慢慢释放出来，延长和增强药物的疗效。The use of polyethylene glycol in the formula can increase the penetration ability of the main drug to the oral mucosa, so that the main drug can better exert its curative effect. Propylene glycol can moisturize the ulcer surface, adhere to the drug and release the drug slowly, prolong and enhance the curative effect of the drug.
2)制备方法：2) Preparation method:
将上述配方中的蜂胶、木糖醇与适当的乳化剂在不锈钢或玻璃混合罐中混和均匀，然后加入矫味剂和蒸馏水搅拌均匀后即成。Mix propolis, xylitol and appropriate emulsifier in the above formula evenly in a stainless steel or glass mixing tank, then add flavoring agent and distilled water and stir evenly.
上述乳化剂是丙二醇、聚乙二醇(分子量200-6000)、丙三醇、乙基羟乙基纤维素、甲基纤维素、单硬脂酸甘油酯、羟化卵磷脂、乙酰化单甘油酯、三羟基甲烷、干酪素、乙二醇单硬脂酸酯、二乙酰单甘油酯、醋酸一脂肪酸甘油酯、木糖醇酐单油酸酯、海藻酸丙二醇酯、乙醇中的一种或几种。The above-mentioned emulsifiers are propylene glycol, polyethylene glycol (molecular weight 200-6000), glycerol, ethyl hydroxyethyl cellulose, methyl cellulose, glyceryl monostearate, hydroxylated lecithin, acetylated monoglycerin Esters, Trihydroxymethane, Casein, Ethylene Glycol Monostearate, Diacetyl Monoglyceride, Monoglyceride Acetate, Xylitol Monooleate, Propylene Glycol Alginate, Ethanol or Several kinds.
上述矫味剂是薄荷脑、桉叶油、白柠檬油、胡萝卜籽油、薄荷油、海狸香、薄荷素油、柠檬油、香茅油、楠叶油、香石竹净油、七里香浸膏、樟脑油、天然香兰素、食用桔子油香精、食用菠萝油香精、食用柠檬油香精、食用香草油香精中的一种或几种。The above-mentioned correctives are menthol, eucalyptus oil, white lemon oil, carrot seed oil, peppermint oil, castoreum, peppermint oil, lemon oil, citronella oil, nan leaf oil, carnation absolute, Qilixiang extract, camphor Oil, natural vanillin, edible orange oil essence, edible pineapple oil essence, edible lemon oil essence, edible vanilla oil essence or more.
使用时取上述浓缩液一份，加入35-40份水。稀释后的溶液将变得混浊，提示使用者该漱口液己可以使用。然后，使用者用约20毫升的稀释后的溶液漱洗口腔后再吐出。When in use, take one part of the above concentrate and add 35-40 parts of water. The diluted solution will turn cloudy, indicating to the user that the mouthwash is ready for use. Then, the user rinses the mouth with about 20 ml of the diluted solution and spits it out.
(四)具体实施方式(4) Specific implementation methods
实施方案1Implementation 1
1)配方1) Recipe
组分 重量份Components Parts by weight
蜂胶 1Propolis 1
木糖醇 8Xylitol 8
聚乙二醇(分子量6000) 6Polyethylene glycol (molecular weight 6000) 6
丙二醇 55Propylene Glycol 55
丙三醇 10Glycerol 10
薄荷脑 0.03Menthol 0.03
蒸馏水 10distilled water 10
配方中采用聚乙二醇可增加主药对口腔粘膜的穿透能力，使主药更好发挥疗效，丙三醇具有滋润溃疡面，粘附药物使药物慢慢释放出来，延长和增强药物的疗效；The use of polyethylene glycol in the formula can increase the penetrating ability of the main drug to the oral mucosa, so that the main drug can better exert its curative effect. Glycerol can moisturize the ulcer surface, adhere to the drug and release the drug slowly, prolong and enhance the drug's efficacy. curative effect;
2)制备方法：2) Preparation method:
将上述配方中的聚乙二醇(分子量6000)溶于部分热的蒸馏水中，再将蜂胶、丙二醇、丙三醇与其混和均匀，然后加入木糖醇、薄荷脑和剩余的蒸馏水搅拌均匀后即成。Dissolve the polyethylene glycol (molecular weight 6000) in the above formula in some hot distilled water, then mix propolis, propylene glycol, and glycerin with it evenly, then add xylitol, menthol and the remaining distilled water and stir evenly. become.
本品为棕色的澄明液体，气味芳香，味甜略苦，漱口有清凉感。This product is a brown clear liquid with a fragrant smell, sweet and slightly bitter taste, and has a refreshing feeling after rinsing the mouth.
实施方案2Embodiment 2
1)配方1) Recipe
组分 重量份Components Parts by weight
蜂胶 0.5Propolis 0.5
木糖醇 6Xylitol 6
聚乙二醇(分子量6000) 6Polyethylene glycol (molecular weight 6000) 6
丙二醇 67Propylene Glycol 67
天然香兰素 0.5Natural vanillin 0.5
蒸馏水 20distilled water 20
2)制备方法：2) Preparation method:
将上述配方中的聚乙二醇(分子量6000)溶于部分热的蒸馏水中，再将蜂胶、丙二醇与其混和均匀，然后加入天然香兰素、木糖醇和剩余的蒸馏水搅拌均匀后即成。Dissolve the polyethylene glycol (molecular weight 6000) in the above formula in partly hot distilled water, then mix propolis and propylene glycol with it evenly, then add natural vanillin, xylitol and the remaining distilled water and stir evenly.
本品为棕色的澄明液体，气味芳香，味甜略苦，漱口有清凉感。This product is a brown clear liquid with a fragrant smell, sweet and slightly bitter taste, and has a refreshing feeling after rinsing the mouth.
实施方案3Embodiment 3
1)配方1) Recipe
组分 重量份Components Parts by weight
蜂胶 0.5Propolis 0.5
木糖醇 6Xylitol 6
聚乙二醇(分子量6000) 1Polyethylene glycol (molecular weight 6000) 1
丙二醇 15Propylene Glycol 15
乙醇 10Ethanol 10
食用柠檬油香精 0.05Edible lemon oil flavor 0.05
蒸馏水 77.5Distilled water 77.5
2制备方法：2 preparation method:
将上述配方中的蜂胶、木糖醇与丙二醇、丙三醇在不锈钢或玻璃混合罐中混和均匀，然后加入薄荷脑和蒸馏水搅拌均匀后即成。Mix propolis, xylitol, propylene glycol and glycerol in the above formula evenly in a stainless steel or glass mixing tank, then add menthol and distilled water and stir evenly.
将上述配方中的聚乙二醇(分子量6000)溶于部分热的蒸馏水中，再将蜂胶、乙醇、丙二醇与其混和均匀，然后加入木糖醇、食用柠檬油香精和剩余的蒸馏水搅拌均匀后即成。Dissolve the polyethylene glycol (molecular weight 6000) in the above formula in some hot distilled water, then mix propolis, ethanol, propylene glycol with it evenly, then add xylitol, edible lemon oil essence and remaining distilled water and stir evenly. become.
本品为棕色的澄明液体，气味芳香，味甜略苦，漱口有清凉感。This product is a brown clear liquid with a fragrant smell, sweet and slightly bitter taste, and has a refreshing feeling after rinsing the mouth.
Claims (4)
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100398091C (en) * | 2005-05-20 | 2008-07-02 | 远景生物科技（上海）有限公司 | An anti-cavity toothpaste with natural substances for children and method for making same |
| CN1857194B (en) * | 2006-03-03 | 2010-12-22 | 田昆 | Compound Tala gargle and its preparing process |
| CN103735481A (en) * | 2013-06-29 | 2014-04-23 | 明光市昊昊蜂业有限公司 | Antisepsis and anti-inflammation mouth rinse and preparation method thereof |
| CN105998549A (en) * | 2016-06-29 | 2016-10-12 | 何勤 | Traditional Chinese medicine compound for treating chronic periodontitis |
| CN106727249A (en) * | 2017-02-21 | 2017-05-31 | 糖友管家（北京）健康管理有限公司 | A kind of mouthwash and preparation method thereof |
| CN107184530A (en) * | 2017-05-24 | 2017-09-22 | 深圳市欧斯特尔实业有限公司 | A kind of mouthwash and preparation method thereof |
| CN107929217A (en) * | 2018-01-22 | 2018-04-20 | 郭心畅 | Propolis herbal mouthwash |
| CN110755355A (en) * | 2019-08-06 | 2020-02-07 | 江苏蜂奥生物科技有限公司 | Propolis toothpaste and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK200000413A (en) * | 2000-03-14 | 2000-03-14 | Novo Nordisk As | Oral care compositions comprising enzymes with anti-halitosis or plaque removing activity |
| CN100335081C (en) * | 2002-01-26 | 2007-09-05 | Mst有限公司 | Composition containing Moutan root bark extract as an active ingredient |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100398091C (en) * | 2005-05-20 | 2008-07-02 | 远景生物科技（上海）有限公司 | An anti-cavity toothpaste with natural substances for children and method for making same |
| CN1857194B (en) * | 2006-03-03 | 2010-12-22 | 田昆 | Compound Tala gargle and its preparing process |
| CN103735481A (en) * | 2013-06-29 | 2014-04-23 | 明光市昊昊蜂业有限公司 | Antisepsis and anti-inflammation mouth rinse and preparation method thereof |
| CN105998549A (en) * | 2016-06-29 | 2016-10-12 | 何勤 | Traditional Chinese medicine compound for treating chronic periodontitis |
| CN106727249A (en) * | 2017-02-21 | 2017-05-31 | 糖友管家（北京）健康管理有限公司 | A kind of mouthwash and preparation method thereof |
| CN106727249B (en) * | 2017-02-21 | 2020-12-08 | 糖友管家（北京）健康管理有限公司 | Mouthwash and preparation method thereof |
| CN107184530A (en) * | 2017-05-24 | 2017-09-22 | 深圳市欧斯特尔实业有限公司 | A kind of mouthwash and preparation method thereof |
| CN107929217A (en) * | 2018-01-22 | 2018-04-20 | 郭心畅 | Propolis herbal mouthwash |
| CN110755355A (en) * | 2019-08-06 | 2020-02-07 | 江苏蜂奥生物科技有限公司 | Propolis toothpaste and preparation method thereof |
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| Publication number | Publication date |
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| CN100336499C (en) | 2007-09-12 |
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