CN1544018A - Yinzhihuang powder injection and its preparation process - Google Patents
Yinzhihuang powder injection and its preparation process Download PDFInfo
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- CN1544018A CN1544018A CNA2003101087184A CN200310108718A CN1544018A CN 1544018 A CN1544018 A CN 1544018A CN A2003101087184 A CNA2003101087184 A CN A2003101087184A CN 200310108718 A CN200310108718 A CN 200310108718A CN 1544018 A CN1544018 A CN 1544018A
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- Prior art keywords
- salt
- injection
- extract
- cape jasmine
- bloom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000002347 injection Methods 0.000 title claims description 30
- 239000007924 injection Substances 0.000 title claims description 30
- 238000002360 preparation method Methods 0.000 title claims description 18
- 239000000843 powder Substances 0.000 title description 4
- 239000008865 yin zhi huang Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims abstract description 61
- 239000000284 extract Substances 0.000 claims abstract description 50
- 244000111489 Gardenia augusta Species 0.000 claims abstract description 18
- 235000018958 Gardenia augusta Nutrition 0.000 claims abstract description 18
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 claims abstract description 17
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 claims abstract description 17
- 229960003321 baicalin Drugs 0.000 claims abstract description 17
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 claims abstract description 17
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- 241000628997 Flos Species 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 12
- 239000002671 adjuvant Substances 0.000 claims description 10
- 238000001694 spray drying Methods 0.000 claims description 8
- 239000008215 water for injection Substances 0.000 claims description 7
- 238000012856 packing Methods 0.000 claims description 6
- 238000007789 sealing Methods 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 6
- 238000001179 sorption measurement Methods 0.000 claims description 6
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
- 229930195725 Mannitol Natural products 0.000 claims description 4
- 238000004108 freeze drying Methods 0.000 claims description 4
- 239000000594 mannitol Substances 0.000 claims description 4
- 235000010355 mannitol Nutrition 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 206010023126 Jaundice Diseases 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims description 2
- 229920003081 Povidone K 30 Polymers 0.000 claims description 2
- 159000000007 calcium salts Chemical class 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 159000000003 magnesium salts Chemical class 0.000 claims description 2
- 229960003194 meglumine Drugs 0.000 claims description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 claims description 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 2
- 159000000000 sodium salts Chemical class 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 5
- 241000205585 Aquilegia canadensis Species 0.000 abstract description 2
- 235000003826 Artemisia Nutrition 0.000 abstract 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 abstract 1
- 240000006891 Artemisia vulgaris Species 0.000 abstract 1
- 235000009052 artemisia Nutrition 0.000 abstract 1
- 238000001784 detoxification Methods 0.000 abstract 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 6
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 6
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 6
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 6
- 229940074393 chlorogenic acid Drugs 0.000 description 6
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 6
- 235000001368 chlorogenic acid Nutrition 0.000 description 6
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 206010008909 Chronic Hepatitis Diseases 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000012869 ethanol precipitation Methods 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000005325 percolation Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a medicament for heat-clearing, detoxification and removing dampness, which comprises capilary Artemisia extractive or its salt, cape jasmine extract or its salt, baicalin or its salt, honeysuckle flower extract or its salt and water-soluble medicinal findings.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of pharmaceutical preparation of mattress Cape jasmine Huang,, the invention still further relates to the preparation method of said preparation simultaneously more specifically to a kind of mattress Cape jasmine bloom injection.
Background technology
" mattress Cape jasmine Huang " is a name side of China's traditional Chinese medical science, and heat clearing away is arranged on the Chinese medicine, detoxifcation, dampness removing, the function of jaundice eliminating.Be used for dampness-heat in the liver and gallbladder, appearance is known Huang, distending pain in the chest and hypochondrium, nausea and vomiting, yellowish or reddish urine, diseases such as acute, delay property, chronic hepatitis.The preparation of " mattress Cape jasmine Huang " mainly contains water for injection injection and tablet at present clinically.Aqueous injection technology is more backward, and stable effective ingredients is poor, and the impurity content height causes untoward reaction more.Therefore, adopting the modern crafts means that " mattress Cape jasmine Huang " carried out secondary development, is the needs of the modernization of Chinese medicine.
Summary of the invention
The object of the present invention is to provide a kind of steady quality, impurity content is few, untoward reaction is little mattress Cape jasmine bloom injection and preparation method thereof.
According to tcm prescription, in conjunction with the modern Chinese medicine preparation method, mattress Cape jasmine bloom injection is made by Herba Artemisiae Scopariae extract or its salt, Fructus Gardeniae extract or its salt, baicalin or its salt, Flos Lonicerae extract or its salt and water-soluble injection adjuvant.The ratio range by weight of its Herba Artemisiae Scopariae extract or its salt, Fructus Gardeniae extract or its salt, baicalin or its salt, Flos Lonicerae extract or its salt and water-soluble injection adjuvant is: (1～100): (1～10): (0.1～100): (1～10): (1～100).More suitable weight proportion scope is: (3～8): (2～4): (15～25): (2～6): (10～30).
Above-mentioned water-soluble injection adjuvant is one or more in meglumine, mannitol, 30 POVIDONE K 30 BP/USP 30, glucose, the lactose, and it act as hydrotropy, shaping etc.
The salt of four kinds of used main components can be acceptable salt on sodium salt, potassium salt, calcium salt, magnesium salt or other physiology in the prescription.
The preparation method of above-mentioned injectable powder is as follows:
1, the preparation of lyophilized injectable powder: adopt freeze-drying.Concrete steps are: get Herba Artemisiae Scopariae extract or its salt, Fructus Gardeniae extract or its salt, baicalin or its salt, Flos Lonicerae extract or its salt of recipe quantity, add the water for injection of 60% recipe quantity, dissolve with 10%NaOH, transfer pH to dissolve fully to extract, add injection supplementary material, dissolving adds activated carbon adsorption, filter, standardize solution, fine straining, packing, lyophilizing, sealing by fusing are promptly.
2, the preparation of spray drying injectable powder: adopt spray drying method, concrete steps are: get Herba Artemisiae Scopariae extract or its salt, Fructus Gardeniae extract or its salt, baicalin or its salt, Flos Lonicerae extract or its salt of recipe quantity, add the water for injection of 60% recipe quantity, with the 10%NaOH dissolving, transfer pH to dissolve fully, the adding injection supplementary material to extract, dissolving, add activated carbon adsorption, filter standardize solution, fine straining, spray drying, packing, sealing by fusing is promptly.
The present invention adopts modern crafts, makes the mattress Cape jasmine bloom injection that stability is high, impurity content is few, untoward reaction is little, complies with the requirement of the modernization of Chinese medicine.
The specific embodiment
The invention is further illustrated by the following examples.
Embodiment 1
Herba Artemisiae Scopariae extract or its salt 12g
Fructus Gardeniae extract or its salt 6.4g
Baicalin or its salt 40g
Flos Lonicerae extract or its salt (in chlorogenic acid) 8g
Mannitol 66.4g
Make 1000 altogether
Preparation method: get baicalin or its salt and add an amount of moistening of water, dissolve with sodium hydroxide solution; Three flavors such as all the other Herba Artemisiae Scopariae extract are dissolved in water respectively, and other gets mannitol and is dissolved in water, and mixing is regulated pH value, is diluted to 2000ml with water for injection, adds activated carbon adsorption, filter, and packing, lyophilizing, sealing by fusing is promptly.
Annotate: 1. Herba Artemisiae Scopariae extract is 90% ethanol percolation extract of Herba Artemisiae Scopariae, removes grease such as chlorophyll, the solid extract that makes through drying under reduced pressure.
2. Fructus Gardeniae extract is the 70% alcohol reflux liquid of Fructus Gardeniae, uses 95% ethanol precipitation, the solid extract that makes through drying under reduced pressure.
3. baicalin is the decocting liquid of Radix Scutellariae, and multiple acid out is made with extra care and got behind hydrochloric acid, contains baicalin (C21H18O11) and should be more than 90%.
4. Flos Lonicerae extract: extracting honeysuckle decocts with water secondary, and each 2 hours, collecting decoction filtered, and filtrate adds lime cream and is adjusted to pH value to 10～12, leave standstill, the leaching precipitation adds suitable quantity of water, adds sulphuric acid and regulates pH value to 6～7, stirs evenly, filter, filtrate is concentrated into the thick paste shape, oven dry, promptly.Containing chlorogenic acid should be more than 18%.
Embodiment 2
Herba Artemisiae Scopariae extract or its salt 22g
Fructus Gardeniae extract or its salt 6.4g
Baicalin or its salt 40g
Flos Lonicerae extract or its salt (in chlorogenic acid) 16g
Adjuvant 0
Make 1000 altogether
Preparation method: get four flavor extracts, it is an amount of to add water, with the sodium hydroxide solution dissolving, regulates pH value, is diluted to 2000ml with water for injection, adds activated carbon adsorption, filters, and spray drying, packing, sealing by fusing is promptly.
Embodiment 3
Herba Artemisiae Scopariae extract or its salt 80g
Fructus Gardeniae extract or its salt 12g
Baicalin or its salt 5g
Flos Lonicerae extract or its salt (in chlorogenic acid) 7g
Adjuvant 32g
Embodiment 4
Herba Artemisiae Scopariae extract or its salt 100g
Fructus Gardeniae extract or its salt 2g
Baicalin or its salt 1g
Flos Lonicerae extract or its salt (in chlorogenic acid) 10g
Adjuvant 60g
Embodiment 5
Herba Artemisiae Scopariae extract or its salt 10g
Fructus Gardeniae extract or its salt 10g
Baicalin or its salt 100g
Flos Lonicerae extract or its salt (in chlorogenic acid) 5g
Adjuvant 80g
Among the embodiment 2-4, the extract of four kinds of Main Ingredients and Appearances is with example 1.Preparation method can adopt freeze-drying or spray drying method etc.Preparation process is with example 1.Prepared mattress Cape jasmine bloom injection all has good performance.
Claims (7)
1, a kind ofly is used for heat clearing away, detoxifcation, dampness removing, the injection mattress Cape jasmine bloom injection of jaundice eliminating, it is characterized in that being formed by Herba Artemisiae Scopariae extract or its salt, Fructus Gardeniae extract or its salt, baicalin or its salt, Flos Lonicerae extract or its salt and the assembly of water-soluble injection adjuvant, wherein the weight proportion scope of 5 kinds of component Herba Artemisiae Scopariae extract or its salt, Fructus Gardeniae extract or its salt, baicalin or its salt, Flos Lonicerae extract or its salt and water-soluble injection adjuvant is: (1～100): (1～10): (0.1～100): (1～10): (0～100).
2, mattress Cape jasmine bloom injection according to claim 1 is characterized in that the weight proportion scope of 5 kinds of components is: (3-8): (2-4): (1 5-25): (2-6): (10-30).
3, mattress Cape jasmine bloom injection according to claim 1 and 2 is characterized in that the water-soluble injection adjuvant is one or more in meglumine, mannitol, 30 POVIDONE K 30 BP/USP 30, glucose, the lactose.
4, mattress Cape jasmine bloom injection according to claim 1 and 2, the salt that it is characterized in that four main components can be acceptable salt on sodium salt, potassium salt, calcium salt, magnesium salt or other physiology.
5, the preparation method of injection mattress Cape jasmine bloom injection according to claim 1 and 2 is characterized in that adopting freeze-drying or spray drying method for preparation.
6, the preparation method of injection mattress Cape jasmine bloom injection according to claim 5 is characterized in that adopting freeze-drying, and concrete steps are: Herba Artemisiae Scopariae extract or its salt, Fructus Gardeniae extract or its salt, baicalin or its salt, Flos Lonicerae extract or its salt of getting recipe quantity, the water for injection that adds 60% recipe quantity with 10%NaOH dissolving, transfers pH to dissolve fully to extract, add injection supplementary material, dissolving adds activated carbon adsorption, filter, standardize solution, fine straining, packing, lyophilizing, sealing by fusing are promptly.
7, the preparation method of injection mattress Cape jasmine bloom injection according to claim 5, it is characterized in that adopting spray drying method, concrete steps are: Herba Artemisiae Scopariae extract or its salt, Fructus Gardeniae extract or its salt, baicalin or its salt, Flos Lonicerae extract or its salt of getting recipe quantity, the water for injection that adds 60% recipe quantity, dissolve with 10%NaOH, transfer pH to dissolve fully to extract, add injection supplementary material, dissolving adds activated carbon adsorption, filter, standardize solution, fine straining, spray drying, packing, sealing by fusing are promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101087184A CN1544018A (en) | 2003-11-19 | 2003-11-19 | Yinzhihuang powder injection and its preparation process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101087184A CN1544018A (en) | 2003-11-19 | 2003-11-19 | Yinzhihuang powder injection and its preparation process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1544018A true CN1544018A (en) | 2004-11-10 |
Family
ID=34334825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2003101087184A Pending CN1544018A (en) | 2003-11-19 | 2003-11-19 | Yinzhihuang powder injection and its preparation process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1544018A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102770150A (en) * | 2009-11-26 | 2012-11-07 | 株式会社爱茉莉太平洋 | Composition for promoting the activity of peroxisome proliferator-activated receptor-delta |
| CN119909117A (en) * | 2025-01-24 | 2025-05-02 | 北京华润高科天然药物有限公司 | A kind of Yinzhihuang oral liquid and preparation method thereof |
-
2003
- 2003-11-19 CN CNA2003101087184A patent/CN1544018A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102770150A (en) * | 2009-11-26 | 2012-11-07 | 株式会社爱茉莉太平洋 | Composition for promoting the activity of peroxisome proliferator-activated receptor-delta |
| CN102770150B (en) * | 2009-11-26 | 2015-06-10 | 株式会社爱茉莉太平洋 | Composition for promoting the activity of peroxisome proliferator-activated receptor-delta |
| US10183048B2 (en) | 2009-11-26 | 2019-01-22 | Amorepacific Corporation | Composition for promoting the activity of peroxisome proliferator-activated receptor-delta |
| CN119909117A (en) * | 2025-01-24 | 2025-05-02 | 北京华润高科天然药物有限公司 | A kind of Yinzhihuang oral liquid and preparation method thereof |
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