CN1411870A - Acupoint plaster and its application - Google Patents
Acupoint plaster and its application Download PDFInfo
- Publication number
- CN1411870A CN1411870A CN 01136097 CN01136097A CN1411870A CN 1411870 A CN1411870 A CN 1411870A CN 01136097 CN01136097 CN 01136097 CN 01136097 A CN01136097 A CN 01136097A CN 1411870 A CN1411870 A CN 1411870A
- Authority
- CN
- China
- Prior art keywords
- carrier
- medicine
- adhesive plaster
- acupoint
- hypnotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000011505 plaster Substances 0.000 title claims abstract description 12
- 239000000853 adhesive Substances 0.000 claims abstract description 11
- 230000001070 adhesive effect Effects 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 230000000147 hypnotic effect Effects 0.000 claims abstract description 6
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000009472 formulation Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 238000004945 emulsification Methods 0.000 claims description 2
- 230000008014 freezing Effects 0.000 claims description 2
- 238000007710 freezing Methods 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 claims 1
- 239000004380 Cholic acid Substances 0.000 claims 1
- 229910000831 Steel Inorganic materials 0.000 claims 1
- 229940125713 antianxiety drug Drugs 0.000 claims 1
- 239000002249 anxiolytic agent Substances 0.000 claims 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 claims 1
- 229960002471 cholic acid Drugs 0.000 claims 1
- 235000019416 cholic acid Nutrition 0.000 claims 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 1
- 239000010959 steel Substances 0.000 claims 1
- 229940125725 tranquilizer Drugs 0.000 claims 1
- 239000003204 tranquilizing agent Substances 0.000 claims 1
- 230000002936 tranquilizing effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 14
- 238000000034 method Methods 0.000 abstract description 4
- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 abstract description 2
- JLPULHDHAOZNQI-JLOPVYAASA-N [(2r)-3-hexadecanoyloxy-2-[(9e,12e)-octadeca-9,12-dienoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC JLPULHDHAOZNQI-JLOPVYAASA-N 0.000 abstract 1
- 230000008595 infiltration Effects 0.000 abstract 1
- 238000001764 infiltration Methods 0.000 abstract 1
- 238000005457 optimization Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 238000001467 acupuncture Methods 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 3
- -1 polyethylene Polymers 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- GJMPSRSMBJLKKB-UHFFFAOYSA-N 3-methylphenylacetic acid Chemical compound CC1=CC=CC(CC(O)=O)=C1 GJMPSRSMBJLKKB-UHFFFAOYSA-N 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- 206010070840 Gastrointestinal tract irritation Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 210000001142 back Anatomy 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 210000003797 carpal joint Anatomy 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000011247 coating layer Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000000624 ear auricle Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000003811 finger Anatomy 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004932 little finger Anatomy 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000001595 mastoid Anatomy 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940117957 triethanolamine hydrochloride Drugs 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Finger-Pressure Massage (AREA)
Abstract
The present invention relates to a medicinal acupoint adhesive plaster, and is characterized by that it utilizes soybean phosphatidyl choline and sodium cholate, medicine and triethanolamine and adopts the optimization and screening process to form optimum prescription and preparation. The above-mentioned medicine can be hypnotic, sedative and antianxietic. Said adhesive plaster carrier can quickly release the medicine, and can make the medicine slowly release and infiltration into skin and come into body circulation by means of acupoint.
Description
Title of the present invention is carrier acupoint adhesive plaster and uses thereof, fundamental of the present invention is a novel formulation carrier acupoint adhesive plaster, the carrier acupoint adhesive plaster belongs to a kind of novel form in the Transdermal absorption dosage form, mainly be to prepare the carrier transfer body that makes new advances with the new mode of new technique, the patch that makes it to form enters the raising of body circulation ratio than the transdermal agent transdermal of other type, manyly quickly medicine is written in the body, and can be made into rapid release and slow release.If make Anmian point, the doctor bright cave district (master point) that patch spreads on recess behind the dorsum auriculae or add adjunct acupuncture points Shenmen and tsu san li again with new support and hypnotic, make medicine infiltrate through body from the skin layer at acupuncture point, use novel like this patch that medicine and acupuncture point dual function are arranged, increase drug effect.
The present invention uses novel form to make the hypnotic carrier acupoint adhesive plaster peroral dosage form more commonly used than general hypnotic following advantage:
1. good absorbing:
Oral medicine is because disintegration, the dissolubility of gastral acid-base value, medicine and take interacting of other medicine or food etc. simultaneously, the absorption of medicine can be affected, but novel form does not then have these influence factors, and medicine infiltrates and enters the body circulation in the body very soon, so the absorptance oral agents is good.
2. bioavailability height
Oral agents is because the gastral process of digesting and assimilating, plasma concentration curve can occur that peak time is slow, area is less under smooth sharp-pointed, the peak of peak value, novel form since absorb fast, the peak occurs early and high, remove slowly, area increases under the peak, so the bioavailability height.
3. drug effect height
Novel formulation has the dual function at medicine and acupuncture point, and drug effect is higher than peroral dosage form.
4. toxic and side effects is little
Novel formulation GI irritation can not occur.
5. easy to use
Novel formulation does not need glassware for drinking water and water such as teacup when using, unconditional normal use the down.
Embodiment 1.
The preparation of carrier acupoint adhesive plaster
1. carrier prepares S-PC (SPC) alcoholic solution and adds the sodium cholate mixing, add medicine, abundant mixing, add the triethanolamine hydrochloride buffer, make lipid concn become 10% suspension, carry out supersound process freezing, thaw, with in pressure dispersing emulsification machine or the ultrasonic Treatment particle diameter that obtains setting, use the microporous filter membrane degerming, promptly.
2. patch preparation is screened comparison, preparation bank material and pressure sensitive adhesive at common used material such as polyethylene, polyester, porous polypropylene, polyvinyl chloride copolymer, cellulose family etc.
3. seriality coating layer symphysis production. art is adopted in the preparation of carrier patch, comprises preparation, coating, drying, rolling, lamination, cutting, branch metering and the packing etc. of matrix solution.
Embodiment 2.
The use of the hypnotic bromine acyl ammonia methoxytryptamine of carrier acupoint adhesive plaster
1. determine to use master point to sleep peacefully and cure the position of bright cave and adjunct acupuncture points Shenmen, tsu san li, select left and right sides ear and a side upper and lower extremities, totally 4 places for use.
2. take out 4 patches, the thin film on the patch surface of tearing is affixed on place, each acupuncture point with patch, smooths, and massages gently tens times, make patch fully and skin is sticking and, the preparation of can lying in bed is fallen asleep.The particular location at each acupuncture point is as follows: 1. sleep peacefully (or claiming calm) and the bright cave of doctor: recess behind the ear-lobe, mastoid process lower edge.2. Shenmen: carpal joint little finger of toe side, a palm back band recess.3. tsu san li: following 3 cun of knee, lateral of tibia one horizontal finger.
Claims (2)
- The present invention is a kind of novel formulation: carrier acupoint adhesive plaster claim:1. the prescription of carrier and preparation technologyBig phosphatidylcholine+cholic acid steel+about the thing that shows↓+triethanolamine10% lipoid suspension↓ freezing↓ thaw↓ middle pressure dispersing emulsification machineSet particle diameter↓ microporous filter membrane degerming footpathThe carrier transfer body
- 2. the use of carrier acupoint adhesive plaster in hypnotic, tranquilizer, antianxiety drugs
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01136097 CN1411870A (en) | 2001-10-09 | 2001-10-09 | Acupoint plaster and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01136097 CN1411870A (en) | 2001-10-09 | 2001-10-09 | Acupoint plaster and its application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1411870A true CN1411870A (en) | 2003-04-23 |
Family
ID=4673436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01136097 Pending CN1411870A (en) | 2001-10-09 | 2001-10-09 | Acupoint plaster and its application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1411870A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101317819B (en) * | 2007-06-05 | 2012-05-30 | 天津药物研究院 | Transdermal drug delivery preparation of rotigotine flexible liposome and hydrophilic matrix |
| CN107613961A (en) * | 2015-05-19 | 2018-01-19 | 株式会社梅德瑞科思 | Percutaneous liquid preparation |
-
2001
- 2001-10-09 CN CN 01136097 patent/CN1411870A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101317819B (en) * | 2007-06-05 | 2012-05-30 | 天津药物研究院 | Transdermal drug delivery preparation of rotigotine flexible liposome and hydrophilic matrix |
| CN107613961A (en) * | 2015-05-19 | 2018-01-19 | 株式会社梅德瑞科思 | Percutaneous liquid preparation |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |