CN1471845A - Healthy food with glossy and rhizoma as main material and preparing method thereof - Google Patents
Healthy food with glossy and rhizoma as main material and preparing method thereof Download PDFInfo
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Abstract
A health-care food in the form of tablet for improving cerebral oxygen and blood supply and sleep, promoting intelligence development, relaxing senile dementia, etc is prepared from gastrodia tuber and ganoderma through preparing ganoderma powder through drying, pulverizing, extracting in alcohol and then in water, and vacuum drying, preparing gastrodia tuber powder through drying, pulverizing and sieving, mixing them together, wetting with alcohol granulating and tabletting.
Description
Technical field: the present invention relates to a kind of is health food of primary raw material and preparation method thereof with glossy ganoderma and rhizoma Gastrodiae.
Technical background: well-known, progressively quickening along with social modernization's process, the pressure from occupation competition and the life that people experience also increases the weight of thereupon, the insomnia of Chan Shenging therefrom, forgetful, sleepy weak etc. healthy worsen and quality of life decline situation also generally more suitable.Medically, sleep is meant inertia and the non-reactiveness of recurrence, and level of consciousness reduces or disappearance during sleep, and most physiological activity and reaction enter inert condition.By sleep, can make tired nerve cell recover normal physiological function, spirit and muscle power also are effectively restored.The anterior pituitary growth hormone secretion obviously increases during sleep, helps promoting body growth, and makes the synthetic increase of nucleoprotein, the storage that helps remembering.And sleep-disorder is meant the unusual of the unusual of amount of sleep and sleep matter or some clinical symptoms takes place when sleep, reduces or hypersomnia somnambulism etc. as sleep.Above symptom all can cause such as body immunity descend, to the resistance of various diseases weakens, failure of memory, headache etc. influence work, studying and living harmful effect; Cause vegetative nervous disorder, cause senile dementia, make the people cross serious harms such as presenility, shortening life-span.Especially children, as do not have enough sleep, growing of health and intelligence can be influenced.Motherland's medical science is also a lot of to the argumentation of insomnia.The traditional Chinese medical science thinks that insomnia i.e. " being insomnia ", also claims " must not sleep ", " must not crouch ", " insomnia " etc., be because the causes of disease such as diseases caused by external factors or internal injuries, cause visceral dysfunctions such as the heart, liver, courage, spleen, stomach, kidney, confused and worried, so that a kind of disease that often must not fall asleep.As saying in " the typhoid fever six scripts ": " overabundance of YANG leading to deficiency of YIN then must not be slept round the clock, covers night based on the moon, and cloudy arrogant then order closes and crouches and pacify; If the moon is won by sun, must not sleep also " so bother all the night.
Along with the development of society, the quickening of rhythm of life, the incidence of insomnia is in rising trend.According to statistics, there is 30% adult to suffer from insomnia approximately.Thus, the positive order benefit of insomnia becomes puzzlement human physical and mental health's a big disease.Medicine educational circles is also carrying out persevering endeavors for capturing this human spirit's chronic disease for a long time.Yet; though the medicine or the health products kind of the adjusting of using on the market at present sleep are various; but majority is a chemical synthetic drug; as barbiturates hypnotic sedative agent, Benzodiazepines anxiolytic; take back regular meeting and produce after effect, and have habituation, tolerance, easily the property accumulated, influence toxic and side effect such as other physiological functions.
Summary of the invention: it is health food of raw material and preparation method thereof with glossy ganoderma, rhizoma Gastrodiae that the present invention proposes a kind of, this health food is drawn materials natural, and be China's tradition rare Chinese medicine, can improve sleep, Anshen Bunao, take for a long time and also can promote brain blood supply, oxygen supply, enhancement intelligence, the senile dementia symptom of improving, effectively alleviate nervous and anxiety, slow down migraine, cerebral function is had good comprehensive adjustment and improvement effect, be particularly useful for disorder of chronicity nervous function and easy anxiety and tense crowd and improve sleep.Its preparation method is simple, is suitable for large-scale industrial production.
The traditional Chinese medicine and pharmacy theory that the present invention is traditional according to China is a primary raw material to have calm the nerves calm rhizoma Gastrodiae and glossy ganoderma in China's traditional Chinese medicine material, its drug effect clearly, be easy to metabolism, evident in efficacy and toxic and side effect is minimum.
It is the health food of raw material with glossy ganoderma, rhizoma Gastrodiae that the present invention proposes a kind of, is made up of 20%～80% Rhizoma Gastrodiae powder and 80%～20% glossy ganoderma by weight percentage.
Described glossy ganoderma is the extract of Basidiomycetes Polyporaceae (Polyproraceae) Ganoderma (Ganoderma) fungi red sesame G.Lucidum Karst. or purple sesame G.Japonicum Lloyd or its spore powder with crushed sporoderm or not spore powder with crushed sporoderm or fineness 〉=300 purpose superfine powders.
A kind of as the above-mentioned preparation method who states health food, step is as follows:
(1), with rhizoma Gastrodiae clean, dry, pulverize the back and cross 6～No. 9 standard screens, obtain being not less than 100 purpose Rhizoma Gastrodiae fine powders;
(2), with glossy ganoderma clean, dry, pulverize after, with the edible alcohol of 5～10 times of volumes,, must not be less than 8 hours room temperature～70 ℃ lixiviate 2～3 times at every turn, separate the lixiviate material, with the gained leaching liquor concentrated thickness medicinal extract that makes that under 40～60 ℃ of temperature, reduces pressure; Medicinal material after the alcohol extracting is decocted 2～3 times with the distilled water of 5～10 times of volumes again, each decocting time is 1～2 hour, behind the filtering dregs of a decoction, glossy ganoderma water extract is concentrated in 50～60 ℃ of decompressions, in vacuum drier, extract concentrate and the partially mixed back of alcohol extract out residual moisture and ethanol again, promptly get used Ganodenna Lucidum P.E;
(3) with Rhizoma Gastrodiae powder and Ganodenna Lucidum P.E or its spore powder with crushed sporoderm or not spore powder with crushed sporoderm or fineness 〉=300 purpose superfine powders directly mix aftershaping in ratio in the above-mentioned prescription, encapsulated or compressing tablet promptly gets health food.
Above-mentioned preparation method also can clean glossy ganoderma the back meal with 5～10 times of volumes, 1～10% ammoniacal liquor lixiviate 2～3 times, must not be less than 8 hours at every turn, separate the lixiviate material, the ammoniacal liquor extract of glossy ganoderma is concentrated in 50～60 ℃ of decompressions make medicinal extract, the back gets final product with vacuum drier is dry.
Described ethanol is 60～95% edible ethanols, and makes its pH to 4～6 with 2～5mol/L hcl acidifying.
Described weak aqua ammonia concentration is 1～10%.
Described glossy ganoderma alcohol extracting ℃ is carried out in room temperature～70, and glossy ganoderma ammoniacal liquor is carried in room temperature～60 and ℃ to be carried out, and glossy ganoderma water is carried at 80～100 ℃ and being carried out.
Described acidifying ethanol, ammoniacal liquor, water extraction time are 2～3 times, and alcohol and ammoniacal liquor carries and be no less than 8 hours at every turn, and it is 1～2 hour that water is carried.
The concentrate drying of described Ganodenna Lucidum P.E all carries out at low temperature, and the decompression thickening temperature is: alcohol extract is controlled at 30～50 ℃, and the water extract is controlled at 40～60 ℃, and vacuum drying is controlled at below 60 ℃.
Described extract all concentrates the back to reduce pressure dry in vacuum drier.
Rhizoma Gastrodiae (Gastrodia elata) is a kind of traditional rare traditional Chinese medicine of China, and according to the Shennong's Herbal record, rhizoma Gastrodiae has the infantile convulsion of inhibition, loses consciousness, proposes the refreshing effect of gas benefit.It also has suppressing hyperactive liver for calming endogenous wind, ends the effect of convulsion.Research in recent years finds that also rhizoma Gastrodiae also has the intelligence of increasing, brain tonic, function in delaying senility, also has certain curative effect to senile dementia.Glossy ganoderma claims 10000 years gill fungus, Ganoderma Lucidum and polyporus luciduses etc. again, is the general name of Basidiomycetes Polyporaceae (Polyproraceae) Ganoderma (Ganoderma) fungi red sesame G.Lucidum Karst. and purple sesame G.Japonicum Lloyd.Be exactly the famous and precious medicinal fungi of China since ancient times, contain multiple bioactive ingredients, warm in nature, can beneficial essence refresh oneself, strengthening the bones and muscles, cure mainly palpitaition, insomnia, forgetful, neurasthenia, chronic bronchitis, spiritlessness and weakness etc., have calmness, stable effect, can be used for treating diseases such as palpitation and insomnia, forgetful, spiritlessness and weakness.The two compatibility is used except that having the positive cooperativity that improves sleep, and wherein rhizoma Gastrodiae still has breath wind antispastic, ends headache and end dizzy effect, to the tic of treatment spasm, extremity numbness, headache are dizzy special efficacy is also arranged, and is a kind of cerebral tonic tranquillizing good medicine.
Mainly contain bioactive ingredients such as GL-B, ganoderic acid, adenosine and glycoprotein in the glossy ganoderma, have disease-resistant, cure the disease, effect of prolonging life.Numerous pharmaceutical researches and clinical testing proof glossy ganoderma also have following drug effect except that the calmness of calming the nerves: antitumor activity, protein, nucleic acid synthesis accelerant; Regulate nervous system, the non-specific resistancing action of body that gets rid of stress and cause; Protect liver and toxin expelling effect; Regulate cardiovascular system; The relievining asthma of respiratory system, antibechic, phlegm-dispelling functions; Immunoregulation effect; Radiate protective action, so this health food is particularly useful for modern people's long-term care requirement.
The relevant sleep function evaluation test that improves has been carried out in bioactive ingredients that the present invention has respectively according to above-mentioned rhizoma Gastrodiae and glossy ganoderma and pharmacological action thereof, clinical practice.Provide part test data of the present invention below in conjunction with embodiment:
One, biological activity test:
1, tried the thing material: Rhizoma Gastrodiae powder: the rhizoma Gastrodiae medicinal material is clean, dry, No. 8 standard screens are crossed in the pulverizing back; Ganodenna Lucidum P.E: the glossy ganoderma medicinal material is clean, dry, the preparation of method described in claims is pressed in the pulverizing back; Yellow Jackets: AR is provided by Guangzhou Chemical Reagent Factory, lot number: 850601
2, test animal: regular grade Kunming kind healthy male mice is provided the animal quality certification number by Chinese Academy of Sciences's Kunming zooscopy: the real moving card 9712 in Yunnan.
3, experimental technique and step:
(1) sleep latency test: get 160 mouse, be divided into 8 groups at random, 20/group by body weight.Irritate stomach (i.g) by 0.1ml/10g.bw with distilled water for first group; Second group of suspension of pressing 0.1ml/10g.bw i.g.6mg/ml Rhizoma Gastrodiae powder; Press 0.1ml/10g.bw i.g.6mg/ml Ganodenna Lucidum P.E suspension for the 3rd group; The 4th group of suspension of pressing 0.1ml/10g.bwi.g.1mg/ml Rhizoma Gastrodiae powder and 5mg/ml Ganodenna Lucidum P.E; The 5th group of suspension of pressing 0.1ml/10g.bw i.g.2mg/ml Rhizoma Gastrodiae powder and 4mg/ml Ganodenna Lucidum P.E; The 6th group of suspension of pressing 0.1ml/10g.bw i.g.3mg/ml Rhizoma Gastrodiae powder and 3mg/ml Ganodenna Lucidum P.E; The 7th group of suspension of pressing 0.1ml/10g.bw i.g.4mg/ml Rhizoma Gastrodiae powder and 2mg/ml Ganodenna Lucidum P.E; The 8th group of suspension of pressing 0.1ml/10g.bw i.g.5g/ml Rhizoma Gastrodiae powder and 1mg/ml Ganodenna Lucidum P.E; Each treated animal is all fed by last method and was raised 15 days, tests to feed the same day and raises back 10～15min, gives the amobarbital sodium solution of animal lumbar injection hypnosis sub-threshold dose.Observe then each dosage treated animal and negative control treated animal on 37 ± 2 ℃ of hot plates active situation and write down the sleeping rate of each treated animal and sleeping latent time (by the injection yellow Jackets to animal time of areflexia anyway).
(2) prolong test the length of one's sleep: handle with sleep experiment in incubation period.The lumbar injection hypnosis is the amobarbital sodium solution of dosage above threshold.The sleep time of record animal from sleeping (righting reflex loss) to awakening (righting reflex recovery).
4, experimental result:
Single give Rhizoma Gastrodiae powder and Ganodenna Lucidum P.E group sleep latency test and prolong test the length of one's sleep relatively be positive with negative control group, and there were significant differences, embodiment of the invention group and negative control group more all are positive and have very or utmost point significant difference.Experimental result can be referring to following table.
Rhizoma Gastrodiae powder and Ganodenna Lucidum P.E are to the influence of mice sleep (X ± SD)
| Group | The sleeping rate sleep of the Rhizoma Gastrodiae powder dosage Ganodenna Lucidum P.E dosage animal length of one's sleep in incubation period (mg/kg) is (sleeping number of animals (min) (min)/animal sum) (mg/kg) |
| Control group 1234567 | 0??????????????0???????????????4/20??????12.4±3.7???17.8±9.6 60?????????????0???????????????6/20??????9.8±3.5 #??25.7±8.9 #0??????????????60??????????????8/20??????9.3±4.2 #??26.1±11.2 #10?????????????50??????????????19/20 ***?7.9±3.5 ###?32.5±13.4 ##20?????????????40??????????????18/20 ***?8.6±3.9 ##??29.8±15.3 ##30?????????????30??????????????17/20 ***?8.4±4.5 ##??28.3±12.5 ##40?????????????20??????????????17/20 ***?8.5±4.3 ##??27.6±11.3 ##50?????????????10??????????????16/20 ***?9.0±3.9 ##??27.2±10.5 ## |
* expression and blank group are through x
2Check, P＜0.01; * represents P＜0.05; * * represents P＜0.001.
# represents to carry out t check, P＜0.01 with the blank group; ## represents P＜0.05; ### represents P＜0.001.
Two, acute toxicity testing:
1, material and method: the regular grade Kunming mouse, regular grade SD sexal maturity rat is provided by Chinese Academy of Sciences's Kunming zooscopy, the animal quality certification number: the real moving card 9712 in Yunnan.
2, test method and step:
2.1 acute toxicity test in mice: select 10 of body weight 23～30g healthy mices, male and female half and half.Being subjected to amount of reagent is 0.6g/kg.bw, and irritating the stomach amount is 0.2ml/10g.bw, and the continuous irrigation stomach is 3 times on an empty stomach, each 2 hours at interval, irritate behind the stomach activity of close observation mouse and death condition in 4 hours, and feed and observed 14 days, record mouse poisoning manifestations and death condition.2.2 rat acute toxicity test: select 5 of body weight 210～230g healthy rats, complete male.Being tried the agent amount is 0.6g/kg.bw, and irritating the stomach amount is 1ml/100g.bw, and the continuous irrigation stomach is 5 times on an empty stomach, each 2 hours at interval, irritate behind the stomach close observation activities in rats and death condition in 4 hours, and to feed and observed 14 days, the record rat poisons and death condition.
3, experimental result
After the animal used as test medication, minimizing comes into play from about the 10min, the animal performance is quiet, the rat mouse does not all have death during toxicity test, and rat generally shows, body weight, weightening finish, food-intake and food utilization, hematological indices is as hemoglobin (Hb), red blood cell count(RBC) (RBC), white blood cell count(WBC) (WBC) and classification, platelet count (PLT) etc., blood parameters: blood sugar (GLU), triglycerides (TG), cholesterol (CHO), total protein (TP), albumin (ALB), glutamic-pyruvic transaminase (ALT), glutamic-oxalacetic transaminease (AST), urea nitrogen (BU), creatinine (CRE) etc., organ coefficient: to liver, kidney, spleen carries out internal organs/weight ratio pH-value determination pH, calculate organ coefficient (internal organs/body weight * 100), pathological examination: perusal experimental animal main organs pathological change, and to liver, kidney, taste, duodenum, colon, testis carries out the Histopathology cut sections for microscopic examination all acts normally, and points out among this embodiment that directly to take after mixing at 1: 1 with Rhizoma Gastrodiae powder and Ganodenna Lucidum P.E should be safe under normal dose.
Result of the test shows that Rhizoma Gastrodiae powder and Ganodenna Lucidum P.E truly have certain improvement sleep effect, and the two mixture according to a certain percentage can have positive cooperativity preferably, and does not have any bad compatibility reaction.Behind human experiment, further shown the prolongation length of one's sleep that it is clear and definite, improve sleep quality, relax intense strain, alleviate effects such as migraine.And this invention pure natural of drawing materials, process is simple and easy to do, can not bring the material of any toxic side effect into, does not also add any compound, so but long-term safety take.
According to one's analysis, contain volatile oil in the rhizoma Gastrodiae, be easy to volatilization after the heating,, also can cause the significant wastage of medicinal material, bring very big inconvenience to processing simultaneously so the decoction or the boiling drug regimen of custom can not make full use of its effect, and consider that the rhizoma Gastrodiae medicinal material is comparatively famous and precious.So the present invention is used as medicine with Rhizoma Gastrodiae fine powder experimentizing relatively to draw directly with Rhizoma Gastrodiae extract and Rhizoma Gastrodiae powder, can play on the basis of effect of equivalence or synergy, adopt Rhizoma Gastrodiae fine powder directly to be used as medicine, can not only reduce the loss of medicinal material effectively, improve the utilization rate of medicinal material, and processing is convenient, can reduce production costs effectively, reduce the economic pressures of patient's long-term prescription, improve the compliance that it takes this product, reach treatment and the real purpose that keeps healthy.
According to relevant research, contained ganoderic acid in the glossy ganoderma (Ganodenic acid) is a kind of triterpene substance, it has strong pharmacologically active, pain relieving, calmness, inhibition histamine release are arranged, detoxify, protect the liver, kill functions such as tumour cell, be glossy ganoderma mainly contain one of composition, also be the main active that works the health-care efficacy that improves sleep among the present invention.The present invention desires to get the effect of glossy ganoderma for tranquilization, calmness, so in the preparation process of Ganodenna Lucidum P.E, pass through to adopt acidifying ethanol (40%～95% of PH=2～4, V/V), and control extraction temperature, extraction time, increase free ganoderic acid solubility in ethanol to reach, improve the purpose of ganoderic acid content in the extract.Perhaps increase the recovery rate of ganoderic acid by the lixiviate of alkalization water (1%～10% ammoniacal liquor).For guaranteeing product quality, extract the back concentration operation and adopt low-temperature reduced-pressure distillation and vacuum freezing drying method simultaneously.Simultaneously, on the basis of experiment, draw also and can directly adopt not spore powder with crushed sporoderm of glossy ganoderma ultra-fine powder or glossy ganoderma spore powder with crushed sporoderm or glossy ganoderma.
The specific embodiment: the present invention is described in further detail below in conjunction with example.
Embodiment one
A kind of capsule shape glossy ganoderma gastrodia tuber health food.With Ganodenna Lucidum P.E and Rhizoma Gastrodiae powder is raw material, and the preparation method is as follows:
1, with glossy ganoderma---the red sesame G.LucidumKarst. of Gammaproteobacteria Polyporaceae (Polyproraceae) Ganoderma (Ganoderma) fungi cleans, dry, pulverize after, be about 4 60% ethanolic solution to pH with the 2mol/L hcl acidifying of 5 times of volumes in 60 ℃ of branches three times lixiviate 8 hours, 24 hours, 48 hours respectively, merge leaching liquor, decompression distillation is to the medicinal extract shape;
2, the medicinal material filter residue after the alcohol extracting decocted respectively for three times 1 hour, 1.5 hours, 2 hours with 5 times of volume distillation moisture again, merging filtrate, and decompression distillation is to the thickness paste;
3, merge glossy ganoderma alcohol extract and water extract, get Powdered Ganodenna Lucidum P.E through vacuum drying;
4, the rhizoma Gastrodiae medicinal material is cleaned, dry, pulverize after, with No. 6 standard screens screenings, Rhizoma Gastrodiae powder;
5, with Ganodenna Lucidum P.E and Rhizoma Gastrodiae powder geometric ratio (weight ratio) mixing, filled capsules gets final product.
Embodiment two
A kind of capsule shape glossy ganoderma gastrodia tuber health food.With Ganodenna Lucidum P.E and Rhizoma Gastrodiae powder is raw material, and the preparation method is as follows:
1, with glossy ganoderma---the purple sesame G.Japonicum of Basidiomycetes Polyporaceae (Polyproraceae) Ganoderma (Ganoderma) fungi Lloyd cleans, dry, pulverize after, with 5% ammoniacal liquor of 10 times of volumes in 60 ℃ of branches three times lixiviate 8 hours, 24 hours, 48 hours respectively, merge leaching liquor, decompression distillation is to paste;
2, glossy ganoderma extract is got Powdered Ganodenna Lucidum P.E through vacuum drying;
3, the rhizoma Gastrodiae medicinal material is cleaned, dry, pulverize after, with No. 6 standard screens screenings, Rhizoma Gastrodiae powder;
4, with Ganodenna Lucidum P.E and Rhizoma Gastrodiae powder geometric ratio (weight ratio) mixing, filled capsules gets final product.
Embodiment three
A kind of tablets glossy ganoderma gastrodia tuber health food.With Ganodenna Lucidum P.E and Rhizoma Gastrodiae powder is raw material, and the preparation method is as follows:
1, with glossy ganoderma---the red sesame G.Lucidum of Basidiomycetes Polyporaceae (Polyproraceae) Ganoderma (Ganoderma) fungi Karst. cleans, thousand dry, pulverize after, be about 5 95% ethanolic solution to pH with the 5mol/L hcl acidifying of 5 times of volumes in 60 ℃ of branches three times lixiviate 8 hours, 24 hours, 48 hours respectively, merge leaching liquor, decompression distillation is to paste;
2, the medicinal material filter residue decocted respectively for three times 1 hour, 1.5 hours, 2 hours with 5 times of volume distillation moisture again after the alcohol extracting, merging filtrate, and decompression distillation is to the thickness paste;
3, merge alcohol extract and the water extract of glossy ganoderma, get Powdered Ganodenna Lucidum P.E through vacuum drying;
4, the rhizoma Gastrodiae medicinal material is cleaned, dry, pulverize after, with the screening of No. 9 standards of pharmacopoeia sieves, Rhizoma Gastrodiae fine powder;
5, with Ganodenna Lucidum P.E and Rhizoma Gastrodiae powder geometric ratio (weight ratio) mixing, make wetting agent, cross No. 4 standard pharmacopeia sieve series grains, whole grain back compressing tablets and get final product with 5% ethanol.
Embodiment four
A kind of tablets glossy ganoderma gastrodia tuber health food.With Rhizoma Gastrodiae powder and glossy ganoderma ultra-fine powder is raw material, and the preparation method is as follows:
1, the rhizoma Gastrodiae medicinal material is cleaned, dry, pulverize after, with the screening of No. 9 standards of pharmacopoeia sieves, Rhizoma Gastrodiae fine powder;
2, get Rhizoma Gastrodiae fine powder and fineness 〉=300 purpose glossy ganodermas---the superfine powder geometric ratio (weight ratio) of the purple sesame G.Japonicum of Basidiomycetes Polyporaceae (Polyproraceae) Ganoderma (Ganoderma) fungi Lloyd mixes, make wetting agent with 5% ethanol, cross No. 4 standard pharmacopeia sieve series grains, whole grain back compressing tablets and get final product.The obtained health food of above embodiment all shows through human experiment significant improvement sleep, alleviate effects such as nervous anxiety and headache and dizzy.
Claims (10)
1, a kind of is the health food of raw material with glossy ganoderma, rhizoma Gastrodiae, is made up of 20%～80% Rhizoma Gastrodiae powder and 80%～20% glossy ganoderma by weight percentage.
2, glossy ganoderma described in the claim 1 is the extract of Basidiomycetes Polyporaceae (Polyproraceae) Ganoderma (Ganoderma) fungi red sesame G.Lucidum Karst. or purple sesame G.Japonicum Lloyd or its spore powder with crushed sporoderm or not spore powder with crushed sporoderm or fineness 〉=300 purpose superfine powders.
3, a kind of preparation method of health food according to claim 1, step is as follows:
(1), with rhizoma Gastrodiae clean, dry, pulverize the back and cross 6～No. 9 standard screens, obtain being not less than 100 purpose Rhizoma Gastrodiae fine powders;
(2), with glossy ganoderma clean, dry, pulverize after, with the edible alcohol of 5～10 times of volumes,, must not be less than 8 hours room temperature～70 ℃ lixiviate 2～3 times at every turn, separate the lixiviate material, with the gained leaching liquor concentrated thickness medicinal extract that makes that under 40～60 ℃ of temperature, reduces pressure; Medicinal material after the alcohol extracting is decocted 2～3 times with the distilled water of 5～10 times of volumes again, each decocting time is 1～2 hour, behind the filtering dregs of a decoction, glossy ganoderma water extract is concentrated in 50～60 ℃ of decompressions, in vacuum drier, extract concentrate and the partially mixed back of alcohol extract out residual moisture and ethanol again, promptly get used Ganodenna Lucidum P.E;
(3) with Rhizoma Gastrodiae powder and Ganodenna Lucidum P.E or its spore powder with crushed sporoderm or not spore powder with crushed sporoderm or fineness 〉=300 purpose superfine powders directly mix aftershaping in ratio in the above-mentioned prescription, encapsulated or compressing tablet promptly gets health food.
4, preparation method according to claim 2, it is characterized in that: also glossy ganoderma can be cleaned the back meal with 5～10 times of volumes, 1～10% ammoniacal liquor lixiviate 2～3 times, must not be less than 8 hours at every turn, separate the lixiviate material, the ammoniacal liquor extract of glossy ganoderma concentrated in 50～60 ℃ of decompressions make medicinal extract, the back gets final product with vacuum drier is dry.
5, preparation method according to claim 2 is characterized in that used ethanol is 60～95% edible ethanols, and makes its pH to 4～6 with 2～5mol/L hcl acidifying.
6, preparation method according to claim 3 is characterized in that used weak aqua ammonia concentration is 1～10%.
7, according to claim 2 or 3 described preparation methods, it is characterized in that the glossy ganoderma alcohol extracting ℃ carries out in room temperature～70, glossy ganoderma ammoniacal liquor is carried in room temperature～60 and ℃ to be carried out, and glossy ganoderma water is carried at 80～100 ℃ and being carried out.
8, according to claim 2 or 3 described preparation methods, it is characterized in that acidifying ethanol, ammoniacal liquor, water extraction time are 2～3 times, and alcohol and ammoniacal liquor carries and is no less than 8 hours at every turn, it is 1～2 hour that water is carried.
9, preparation method according to claim 2 is characterized in that the concentrate drying of Ganodenna Lucidum P.E all takes low temperature to carry out, and the decompression thickening temperature is: alcohol extract is controlled at 30～50 ℃, and the water extract is controlled at 40～60 ℃, and vacuum drying is controlled at below 60 ℃.
10, preparation method according to claim 2, it is dry in vacuum drier to it is characterized in that extract all concentrates the back to reduce pressure.
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| CN101049435B (en) * | 2006-04-03 | 2011-05-18 | 蹇在金 | Method of preparing nutriment for preventing brain dementia of middle-aged persons and elderly persons |
| CN104872728A (en) * | 2015-05-08 | 2015-09-02 | 苏州葛家坞生物科技有限公司 | Preparation method of lucid ganoderma crab paste and product of preparation method |
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| CN105211886A (en) * | 2015-09-21 | 2016-01-06 | 大方县九龙天麻开发有限公司 | A kind of immunity regulating type Rhizoma gastrodiae beverage and preparation method thereof |
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