CN1327913C - Method and apparatus for dialysate preparation and supply - Google Patents
Method and apparatus for dialysate preparation and supply Download PDFInfo
- Publication number
- CN1327913C CN1327913C CNB2004100269620A CN200410026962A CN1327913C CN 1327913 C CN1327913 C CN 1327913C CN B2004100269620 A CNB2004100269620 A CN B2004100269620A CN 200410026962 A CN200410026962 A CN 200410026962A CN 1327913 C CN1327913 C CN 1327913C
- Authority
- CN
- China
- Prior art keywords
- liquid
- cavity
- dosing
- mixing
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims 2
- 239000007788 liquid Substances 0.000 claims abstract description 79
- 238000001631 haemodialysis Methods 0.000 claims abstract description 17
- 230000000322 hemodialysis Effects 0.000 claims abstract description 17
- 238000002156 mixing Methods 0.000 claims abstract description 13
- 239000012528 membrane Substances 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 238000001514 detection method Methods 0.000 claims description 5
- 230000005540 biological transmission Effects 0.000 claims description 4
- 239000000523 sample Substances 0.000 claims description 4
- 230000008569 process Effects 0.000 abstract description 9
- 238000012423 maintenance Methods 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 2
- 239000000385 dialysis solution Substances 0.000 description 43
- 239000010408 film Substances 0.000 description 29
- 238000000502 dialysis Methods 0.000 description 17
- 239000008280 blood Substances 0.000 description 13
- 210000004369 blood Anatomy 0.000 description 13
- 239000010409 thin film Substances 0.000 description 13
- 239000000243 solution Substances 0.000 description 12
- 208000002925 dental caries Diseases 0.000 description 10
- 230000000694 effects Effects 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 238000001223 reverse osmosis Methods 0.000 description 6
- 239000012141 concentrate Substances 0.000 description 5
- 239000002699 waste material Substances 0.000 description 5
- 230000008859 change Effects 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 239000003053 toxin Substances 0.000 description 4
- 231100000765 toxin Toxicity 0.000 description 4
- 230000007306 turnover Effects 0.000 description 4
- 230000009471 action Effects 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000009740 moulding (composite fabrication) Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 208000001889 Acid-Base Imbalance Diseases 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 230000009183 running Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Images
Landscapes
- External Artificial Organs (AREA)
Abstract
本发明提供一种配液供液方法，主要是利用一腔体进行配液并利用同一腔体进行平衡供液；一种配液供液装置，包括一独立腔体、配液组件，所述腔体内设置有膜，将腔体分隔出最少两个空间，其中一个空间与配液组件相连接形成配液回路。本发明不需停机便可依要求调节透析液流量，具有结构简单，控制容易，制造成本低，维护费用少、安全性高，稳定性好的优点，可较好地应用于血液透析临床治疗过程中。
The invention provides a method for mixing and supplying liquid, mainly using a cavity for liquid mixing and using the same cavity for balanced liquid supply; a liquid mixing and supplying device including an independent cavity and a liquid mixing component. The cavity is provided with a membrane, which separates the cavity into at least two spaces, one of which is connected with the liquid distribution component to form a liquid distribution circuit. The invention can adjust the dialysate flow according to requirements without shutting down, has the advantages of simple structure, easy control, low manufacturing cost, low maintenance cost, high safety and good stability, and can be better applied to the clinical treatment process of hemodialysis middle.
Description
Technical field
The present invention relates to the hemodialysis medical skill, the particularly a kind of dosing of dialysis fluid circuit in the hemodialysis apparatus and method and apparatus of balance feed flow of being applied to.
Background technology
Hemodialysis is the dialyser that blood is made by a kind of semipermeable membrane that can only allow small-molecule substance (as electrolyte, micromolecule kidney toxin) pass through, make the side of blood at film, dialysis solution is at the opposite side of film, the solution of both sides is by disperse, osmosis, be that solute is by the high low side flow of a side direction concentration of concentration, allow in the blood in, the micromolecule toxin may penetrate in the dialysis solution, electrolyte also can reach balance by osmosis, thereby realizes the therapy equipment of blood purification purpose.Existing hemodialysis apparatus mainly comprises blood circuit and dialysis fluid circuit two big ingredients, blood circuit is meant from patient's tremulous pulse blood is drawn, wait across semipermeable membrane and dialysis solution through dialyser and to ooze ion exchange, correct acid base imbalance, remove after toxin and the redundant moisture, return patient's vein; Dialysis fluid circuit is meant that the reverse osmosis water that will introduce is after heating and being configured to the dialysis solution of standard in proportion, the bascule of flowing through, under the effect of bascule, guarantee the balance of the dialysis solution of turnover dialyser, make dialysis solution in dialyser, carry out effectively waiting oozing ion exchange across semipermeable membrane, thereby reach the effect of treatment with blood.The primary structure of existing hemodialysis apparatus as shown in Figure 1, by dialyser 1, bascule 2, ultrafiltrate pump 3, heating liquid dispensing device 4, heat exchanger 5 assemblies such as grade connect and compose, reverse osmosis water carries out heat exchange with the waste liquid of discharging in heat exchanger 5, obtain certain temperature, in heating liquid dispensing device 4, be heated to the temperature of needed by human body, and with the concentrated dialysis A that throws in proportion, the B concentrated solution carries out the normal dialysis liquid of mixed diluting one-tenth and blood of human body intermediate concentration (wait and ooze), effect by bascule (counter balance pocket or ballast pump) 2, make the dialysis solution turnover dialyser 1 and the flow of the bascule 2 of coming in and going out reach balance, and through ultrafiltrate pump 3 extraction human body redundant moisture, thereby the purpose of realization dialysis treatment.By aforementioned dialysis procedure as seen, hemodialysis apparatus will realize the purpose of dialysis treatment, and its key technology is the dosing and the balance feed flow process of standard dialysis solution in the dialysis fluid circuit.In the prior art, Deutsche Bundespatent (patent No. DE4116177) discloses a kind of counter balance pocket, this counter balance pocket is to be divided into two separate spaces by a slice film in an airtight cavity, a space feed liquor, another space drain, thus realize the turnover dialyser and the flow equilibrium of the counter balance pocket of coming in and going out.Japan Patent (patent No. 2002-028230) discloses a kind of liquid dispensing device, the cavity of this liquid dispensing device is divided into I, II, three chambers of III by two active film, behind the feed liquor of I chamber, be extracted into the III chamber through the loop, dissolving tank is set on the loop, dissolving dialysis powder (A, B powder) and dialysis liquid-phase mixing, and intermediary II chamber is used for regulating pondage, to reach the purpose of configuration standard dialysis solution.In aforementioned two patents, Deutsche Bundespatent has solved the equilibrated problem of dialysis fluid circuit feed flow, but dosing need be provided with liquid dispensing device in addition and realize, and the method for synchronous dosing when need adopting feed flow, this method of coming dosing according to flow and flow velocity, usually can appear at that (counter balance pocket) any one electrically-controlled valve asthenia subtracts the problem of unstable that all can cause the change of flow and electrical conductivity occur on the dialysis fluid circuit, directly influence therapeutic effect; Japan Patent has solved the problem of dosing, and dialysis solution feed flow balance also will utilize other bascule to realize, the electrical conductivity of this liquid dispensing device is relatively stable, but owing to be subjected to spatial restriction, not only increased hardware device, and will reach synchronously with bascule, therefore, dialysis fluid flow is difficult to realize arbitrarily adjustable through the flow velocity (flow of unit interval) of dialyser on the dialysis fluid circuit.The principle of aforementioned two patents all is to realize on the basis that the dosing of dialysis fluid circuit and balance feed flow divide two devices to finish; this just causes reverse osmosis water and concentrated A in the dialysis solution dosing process; the mixed proportion of B dialysis solution and reverse osmosis water flow (being dialysate flow); electrical conductivity concentration must be established in advance; can not arbitrarily change in the treatment; regulate these parameters; must shut down earlier and just can reset; again need long time just can reach required electrical conductivity concentration after the start; and shutdown operation is very numerous and diverse in the dialysis procedure; may cause great malpractice; therefore; all existing hemodialysis apparatus are not all shut down the function that changes parameter midway; and current development along with the hemodialysis technology; the treatment project of utilizing the hemodialysis principle to carry out increases; the dialysate flow rate that originally is known as 500ml/min in the world can not satisfy the requirement of clinical treatment; and prior art also can't be implemented in the clinical dialysis procedure situation according to the patient (as blood pressure; pulse) dialysate concentration is carried out online adjustment; therefore clinical treatment wishes can be provided in the hemodialysis apparatus that can adjust dialysate flow rate and electrical conductivity concentration in the dialysis procedure, and existing method that dosing and balance feed flow are realized by two devices respectively in dialysis fluid circuit and device difficulty satisfy the requirements of this respect.
Summary of the invention
The objective of the invention is to overcome the shortcoming of prior art, provide a kind of control simple in structure, easy, safe and reliable, stability is high, volume is little, cost is low, can adjust the method for dialysis solution dosing feed flow in the dialysis fluid circuit of dialysate flow rate in therapeutic process at any time on demand.
Another object of the present invention is to provide a kind of dosing liquid feed device of realizing said method.
Purpose of the present invention is achieved through the following technical solutions: this dosing feed liquid method carries out dosing and utilizes same cavity to carry out the balance feed flow for utilizing a cavity.
Utilize film to be separated out minimum two spaces in the described cavity, one of them space is connected with the dosing assembly and forms the dosing loop.
Described dosing assembly comprises liquid delivery member, concentration micromatic setting, electrical conductivity checkout gear.
Described film can be one or more pieces elastic films.
Utilize two groups of described cavitys to be used, one group (comprising one or more cavity), another group (comprising one or more cavity) was carried out the balance feed flow in dosing; Vice versa.Blood dialysis is continuously carried out.
The dosing liquid feed device of realizing said method comprises an individual cavity, dosing assembly, is provided with film in the described cavity, and cavity is separated out minimum two spaces, and one of them space is connected with the dosing assembly.
The wall perforate of described cavity is equipped with the flexible plug screw that can finely tune spatial volume in the cavity from the outside.
Described film is an elastic film, and its quantity can be one or more pieces; The connected mode of described film and individual cavity is fixedly connected on the cavity inner wall for the edge with film, and the space of the relative both sides of film directly is not communicated with.
Described dosing assembly comprises liquid delivery member, concentration micromatic setting, electrical conductivity checkout gear, and liquid delivery member, concentration micromatic setting and electric conductance detection probe are connected with a spatial entery and delivery port of described cavity.
Described liquid delivery member comprises A, B concentrated solution delivery pump, dialysis solution combination drive pump.
Described concentration micromatic setting comprises motor, gear transmission structure, pull bar, elastica, base, motor is connected with pull bar by gear transmission structure, the end of described pull bar is connected with elastica, elastica is close on the base, the surface of being close to elastica on base is provided with cavity, elastica seals cavity, is provided with water inlet and outlet in the described base and is connected with cavity respectively; Even when elastica is close to susceptor surface, the water inlet in the base all can be communicated with outlet, and motor can be regulated amount infused by the volume that pull bar spurs between thin film change elastica and the cavity, thereby regulates dialysate concentration.
Described concentration micromatic setting can be arranged with the individual cavity branch and be connected by conduit, also can be set directly on the individual cavity, link together with individual cavity, when form that employing links together, directly with the base of individual cavity as the concentration micromatic setting, described elastica directly sealing is installed on the chamber wall of individual cavity.
Described dosing liquid feed device can adopt the use that combines of two individual cavity, so that an individual cavity another individual cavity in dosing is carried out the balance feed flow, vice versa, can make device not operation continuously like this with continuing, uninterruptedly carries out to guarantee blood dialysis.Because be not subjected to the influence of another cavity dosing process during a cavity feed flow, the flow rate during feed flow just can be realized regulating at any time with the needs of clinical treatment; Equally; do not influence the feed flow of another cavity during one cavity dosing; therefore; its concentration electrical conductivity just can realize the situation needs with patient such as blood pressure pulse during dosing; at any time regulate, that is realized in clinical dialysis procedure, need not shutting down and adjust the flow of dialysis solution and the effect of dialysis solution electrical conductivity concentration according to the needs of patient treatment at any time.
The relative prior art of the present invention has following advantage and effect: (1) has overcome prior art can not be adjusted dialysate flow and electrical conductivity concentration in therapeutic process shortcoming; a kind of technology that just can regulate dialysate flow according to the needs of clinical treatment of need not shutting down in treatment clinical course is provided; carry out multinomial blood purification treatment project for clinical, satisfy the patient and take different dialysate flows and concentration that probability is provided at therapeutic process.(2) simple in structure, control is easy, low cost of manufacture, and maintenance cost is few; Because the method applied in the present invention and device thereof are realized dosing and balance feed flow and are finished in same cavity, saved the dosing structure of available technology adopting, and a large amount of hardware setting and the electric-controlled parts that transfer to bascule after the dosing, control principle is greatly simplified, direct production cost is low, and is saving a large amount of time aspect the debugging based on the hemodialysis apparatus that this technology is produced, and the maintenance process of equipment also can be simplified, indirect cost is also low, helps the marketing of product.(3) safe, good stability; Because the dialysis solution dosing is independently finished on the loop one, the configuration of dialysis solution is under the adjusting of electrical conductivity and fine setting, promptly accurately dispose before use and finish, when turning to dialyser to dialyse, do not have the situation of electrical conductivity fluctuation, and dialysis solution is all realized balance at same cavity, mechanism can accurately be controlled, operate fairly simplely, the safety of equipment is higher, good stability.
Description of drawings
Fig. 1 is the fundamental diagram of existing hemodialysis apparatus.
Fig. 2 is the structural representation of dosing liquid feed device of the present invention.
Fig. 3 is the structural representation of the concentration micromatic setting in the dosing liquid feed device shown in Figure 2.
Fig. 4 is another structural representation of dosing liquid feed device of the present invention.
Fig. 5 is the another structural representation of dosing liquid feed device of the present invention.
Fig. 6 is a structural representation again of dosing liquid feed device of the present invention.
The specific embodiment
The present invention is described in further detail below in conjunction with embodiment and accompanying drawing, but embodiments of the present invention are not limited thereto.
Fig. 2 shows specific constructive form of the present invention, as seen from Figure 2, this dosing liquid feed device includes an individual cavity 6, this inside cavity is divided into two chambers 9,10 by thin film 7,8, wherein a thin film 8 is near the chamber wall of individual cavity 6, and perforate is equipped with the flexible plug screw 11 that can finely tune spatial volume in the cavity from the outside on the wall of chamber; A chamber 10 between two thin film 7,8 is provided with dosing inlet and dosing outlet; With pipeline that dosing outlet and dosing inlet is connected on be provided with electromagnetic valve N3, N4, chamber 10 also is provided with the transfusion outlet, with pipeline that transfusion outlet is connected on be provided with electromagnetic valve N2, dosing inlet and dosing outlet are connected with liquid delivery pump 12, concentration micromatic setting, electrical conductivity detection probe 13 through pipeline, form dialysis solution dosing loop; Another chamber 9 is provided with liquid in-out mouth (be the import and the outlet of liquid, also can be provided with inlet and liquid outlet respectively separately) in the cavity, and the pipeline that is connected with this liquid in-out mouth is provided with electromagnetic valve N5, N6.
The concrete structure of described concentration micromatic setting as shown in Figure 3, by motor 14, geared sleeve 15, pull bar 16, briquetting 17, elastic film 18, base 19 constitutes, motor 14 is connected with pull bar 16 by geared sleeve 15, the end seal of pull bar 16 is connected with elastic film 18, elastic film 18 is close on the base 19, briquetting 17 tightly suppresses elastic film 18, the surface of being close to elastic film 18 on base 19 is provided with cavity 20, elastic film 18 can seal cavity 20, be provided with the water inlet 21 and the outlet 22 that are connected with cavity 20 respectively in the described base 19, even when elastic film 18 is close to base 19 surfaces, the water inlet 21 in the base 19 all can be communicated with outlet 22.The operation principle of this concentration micromatic setting is that motor 14 is regulated amount infused by the volume that pull bar 16 pulling elastic films 18 change between elastic film 18 and the cavity 20, thereby adjusting dialysate concentration, concrete adjustment process is: when motor 14 is just changeing, driven wheel cover 15, geared sleeve 15 pulling pull bars 16, pull bar 16 pull-up elastic films 18 increase the space between elastic film 18 and base 19 surfaces, thereby increase the feed liquor amount; During motor 14 counter-rotatings, geared sleeve 15 reverse rotations, pull bar 16 promotes elastic film 18 and resets, and elastic film 18 is replied and is adjacent to base 19 surfaces, makes the space between elastic film 18 and base 19 surfaces reply initial condition, thereby reduces the feed liquor amount.
This dosing liquid feed device is connected in the hemodialysis apparatus, and as shown in Figure 2, the transfusion outlet of individual cavity 6 and liquid in-out mouth are connected with dialyser 23 by pipeline respectively, form dialysis fluid circuit; The dosing inlet of individual cavity 6 is connected with the outlet 22 (as shown in Figure 3) of heater 24 and concentration micromatic setting by pipeline simultaneously, the dosing outlet of individual cavity 6 is connected with the water inlet 21 (as shown in Figure 3) of concentration micromatic setting by pipeline, and the outlet 22 of concentration micromatic setting and water inlet 21 are connected by concentrate pump 26,27 and pipeline with A, B concentrated solution storage tank respectively; In addition, the reverse osmosis water supply line is connected with heater 24 by heat exchanger 25.
Method of work of the present invention is as shown in Figure 2: reverse osmosis water (RO water) enters heater 24 through heat exchanger 25, after being heated to 37 ℃, be pressed in the chamber 10 by delivery pump 12, by concentrate pump 26,27 A, B concentrated solution are sent in the chamber 10 to scale during intaking, formation is mixed in proportion the dialysis solution after the dilution; Dialysis solution are pushed two thin film 7,8 of this chamber the both sides inwall of cavity 6 in the chamber 10, make the dialysis solution that is full of in the whole cavity 6 after the dilution.After closing RO water (promptly closing electromagnetic valve N1), under the delivery pump 12 in dosing loop drives, dialysis solution in the beginning circular chamber 10, detect electrical conductivity by electrical conductivity detection probe 13 simultaneously, if electrical conductivity is on the low side, then instruct concentrate pump 26,27 to cover A, B concentrated solution, simultaneously motor 14 pulling pull bars 16, pull bar 16 pulling thin film 18 increase the space for covering A, B concentrated solution; If electrical conductivity is higher, same instruction step motor 14 pulling thin film 18 increase the space for covering RO water (open electromagnetic valve N1 this moment, stops concentrate pump 26,27 runnings simultaneously); So fine setting covers and concentrates A, B concentrated solution and corresponding RO water, finally obtains the normal dialysis liquid of desired concn.
After configuring normal dialysis liquid, under the effect of dialysis solution delivery pump 28, dialysis solution is drawn into dialyser 23 by the transfusion outlet (opens solenoid valve N2 this moment) of chamber 10, opens solenoid valve N5 meanwhile, close electromagnetic valve N6, make the former waste liquid of fresh dialysis fluid be admitted to another chamber 9 through in dialyser 23, carrying out forming after the exchange of toxin plasma with blood in chamber 10.Thin film 7 between chamber 9 and the chamber 10 is to chamber 10 side shiftings, therefore sends the amount of liquid of chamber 9 to and the amount of liquid of extruder chamber 10 is reached balance; Equally, the liquid of turnover dialyser 23 is also reached balance, has so promptly realized the dosing of dialysis solution and the operational approach of finishing in same cavity to dialyser balance feed flow.
After the liquid that places chamber 10 was admitted to chamber 9 fully, the thin film 7,8 of intracavity was close to a side of cavity 6 inwalls fully, and at this moment whole cavity 6 has been full of exhausted waste liquid.When the dosing feed flow process next time begins, be transfused to chamber 10 behind 37 ℃ RO water mixing A, the B concentrated solution, thin film 7 between chamber 10,9 is to chamber 9 side shiftings, the waste liquid that is positioned at chamber 9 is extruded (this moment opens solenoid valve N6, close electromagnetic valve N5), waste liquid is dropped behind heat exchanger 25 heating RO water.Behind 10 fulls of liquid of chamber, promptly begin next cyclic process identical with aforementioned process.
Present embodiment is identical with embodiment 1 except that following characteristics: adopt the use that links together of two identical cavitys, concrete connected mode is seen Fig. 4, and two identical individual cavity connect together.Like this, utilize two cavitys, when a cavity dosing with spline structure, another cavity carries out the balance feed flow, and this cavity feed flow finishes when entering dosing, and the cavity of another dosing state then enters the balance feed flow, two cavitys are used alternatingly, and can realize to dialyser 23 uninterrupted balance feed flows.Because two cavitys all use same dosing control, it is consistent that the volume of two cavity intracavity is wanted, otherwise deviation can appear in the electrical conductivity of normal dialysis liquid; For this reason, utilize flexible plug screw 11 on the cavity wall to adjust the variation of cavity internal volume, make the volume of two cavitys reach consistent.
Present embodiment is identical with embodiment 2 except that following characteristics: as shown in Figure 5, a slice thin film only is set all in two cavitys; The flexible plug screw 11 of this structural requirement on cavity wall both can have been adjusted two intravital volumes in chamber, must stand fluid pressure in the cavity again and non-leakage.
Present embodiment is identical with embodiment 3 except that following characteristics: as shown in Figure 6, concentration micromatic setting among the cancellation embodiment 3, the concentration micromatic setting is directly installed on the chamber wall of two cavitys, with the base of chamber wall as the concentration micromatic setting, the elastic film of concentration micromatic setting seals respectively on the chamber wall that is installed in two cavitys.Like this, on the dialysis solution dosing loop of two interior each self-formings of cavity, do not need to connect flexible micromatic setting through pipeline.When RO water mixes with A, B concentrated solution, after entering chamber of cavity, when dialysis solution flows in the cocycle of dosing loop, need cover A, B concentrated solution or RO water, then instruction is positioned at two motors on the wall of chamber and finely tunes respectively, obtains the normal dialysis liquid of specified electrical conductivity with this.
Structure in the present embodiment also can be cancelled a cavity, and its mechanism is close with embodiment 1.
Embodiment 5
Present embodiment is identical with embodiment 4 except that following characteristics: two thin film all are set in two cavitys, and the cancellation sealing is installed in the elastic film of two concentration micromatic settings on the body lumen wall of chamber; The action principle of this structure is with embodiment 4.
In addition; the version and the distortion thereof of the thin film more than two are set respectively in plural cavity; as long as its equivalence of adopting the model of action that carries out dosing and balance feed flow at same cavity all to belong to the present invention program is replaced, should belong within protection scope of the present invention.
Claims (9)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100269620A CN1327913C (en) | 2004-04-23 | 2004-04-23 | Method and apparatus for dialysate preparation and supply |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100269620A CN1327913C (en) | 2004-04-23 | 2004-04-23 | Method and apparatus for dialysate preparation and supply |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1569265A CN1569265A (en) | 2005-01-26 |
| CN1327913C true CN1327913C (en) | 2007-07-25 |
Family
ID=34480811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100269620A Expired - Lifetime CN1327913C (en) | 2004-04-23 | 2004-04-23 | Method and apparatus for dialysate preparation and supply |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1327913C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010130202A1 (en) * | 2009-05-15 | 2010-11-18 | 重庆山外山科技有限公司 | Volume-varied balancer for purifying blood |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102698332B (en) * | 2006-10-30 | 2015-08-05 | 甘布罗伦迪亚股份公司 | For the air separator of extracorporeal fluid treatment sets |
| CA2753895C (en) | 2006-10-30 | 2013-12-10 | Gambro Lundia Ab | Air separator for extracorporeal fluid treatment sets |
| CN101342389B (en) * | 2008-09-03 | 2010-06-02 | 荣维淳 | Full-automatic liquid preparation machine |
| CN104383619B (en) * | 2014-12-03 | 2016-08-24 | 佟博弘 | Dialysate flow intelligent regulating device and method, dialysis machine |
| US10625009B2 (en) | 2016-02-17 | 2020-04-21 | Baxter International Inc. | Airtrap, system and method for removing microbubbles from a fluid stream |
| CN106902408B (en) * | 2017-02-22 | 2019-08-23 | 广州大学 | A kind of blood purification metering device and method |
| CN112843362A (en) * | 2020-12-31 | 2021-05-28 | 江苏关怀医疗科技有限公司 | Dialysate preparation and supply device for dialysate system |
| CN115990429A (en) * | 2023-02-23 | 2023-04-21 | 北京迈淩医疗技术发展有限公司 | Concentrated dialysis solution preparation equipment and preparation method thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4366061A (en) * | 1980-01-23 | 1982-12-28 | Cordis Dow Corp. | Automated diaphragm apparatus and method for controlling negative pressure hemodialysis treatment |
| US6042784A (en) * | 1997-03-01 | 2000-03-28 | Fresenius Medical Care Deutschland Gmbh | Method and apparatus for ultrafiltration in hemodialysis |
| US6277272B1 (en) * | 1998-10-07 | 2001-08-21 | Nipro Corporation | Dialysis system and cleaning and priming method thereof |
| EP1163916A2 (en) * | 2000-06-15 | 2001-12-19 | Nipro Corporation | Apparatus for preparing solutions |
| CN1404882A (en) * | 2002-10-28 | 2003-03-26 | 尹良红 | Balancing pump and its driving method and use |
| US6595944B2 (en) * | 2000-06-17 | 2003-07-22 | Fresenius Medical Care Deutschland Gmbh | Dialysis machine and method of operating a dialysis machine |
| US6649057B2 (en) * | 2000-07-14 | 2003-11-18 | Nipro Corporation | Dialysate preparing apparatus |
| CN2689952Y (en) * | 2004-04-23 | 2005-04-06 | 暨南大学 | Liquid distribution and supply device |
-
2004
- 2004-04-23 CN CNB2004100269620A patent/CN1327913C/en not_active Expired - Lifetime
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4366061A (en) * | 1980-01-23 | 1982-12-28 | Cordis Dow Corp. | Automated diaphragm apparatus and method for controlling negative pressure hemodialysis treatment |
| US6042784A (en) * | 1997-03-01 | 2000-03-28 | Fresenius Medical Care Deutschland Gmbh | Method and apparatus for ultrafiltration in hemodialysis |
| US6277272B1 (en) * | 1998-10-07 | 2001-08-21 | Nipro Corporation | Dialysis system and cleaning and priming method thereof |
| EP1163916A2 (en) * | 2000-06-15 | 2001-12-19 | Nipro Corporation | Apparatus for preparing solutions |
| US6595944B2 (en) * | 2000-06-17 | 2003-07-22 | Fresenius Medical Care Deutschland Gmbh | Dialysis machine and method of operating a dialysis machine |
| US6649057B2 (en) * | 2000-07-14 | 2003-11-18 | Nipro Corporation | Dialysate preparing apparatus |
| CN1404882A (en) * | 2002-10-28 | 2003-03-26 | 尹良红 | Balancing pump and its driving method and use |
| CN2689952Y (en) * | 2004-04-23 | 2005-04-06 | 暨南大学 | Liquid distribution and supply device |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010130202A1 (en) * | 2009-05-15 | 2010-11-18 | 重庆山外山科技有限公司 | Volume-varied balancer for purifying blood |
| RU2495680C2 (en) * | 2009-05-15 | 2013-10-20 | ЧУНЦИН ШАНЬВАЙШАНЬ САЙЕНС энд ТЕКНОЛОДЖИ КО., ЛТД. | Variable-volume compensator for blood purification |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1569265A (en) | 2005-01-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12496383B2 (en) | Flow regulation device | |
| JP4235555B2 (en) | Extracorporeal circuit priming method and dialysis device | |
| EP3033121B1 (en) | Dual haemodialysis and haemodiafiltration blood treatment device | |
| CN101708347B (en) | Hemodialysis system for controlling electric conduction and ultra-filtration by weighing | |
| US12070539B2 (en) | Extracorporeal blood treatment method | |
| CN1327913C (en) | Method and apparatus for dialysate preparation and supply | |
| JP2018525091A (en) | Portable ultrafiltration unit and device for supplying dialysate to ultrafiltration unit | |
| CN2689952Y (en) | Liquid distribution and supply device | |
| JP7317008B2 (en) | Dialysis system with carbon dioxide generation and prime | |
| US12491294B2 (en) | Peritoneal diaylsis system and cassettes therefor | |
| EP4188475B1 (en) | Renal failure therapy systems having reduced time between treatments | |
| JP2025509791A (en) | Production of medical fluids for renal replacement therapy | |
| WO2015173713A1 (en) | Single needle hemo(dia)filtration apparatus | |
| CN110141702A (en) | Inversion hemodiafiltration method and apparatus, blood filter component and its pipeline assembly | |
| AU2023417284A1 (en) | Disposable set, apparatus and procedure of blood recirculation in an extracorporeal blood treatment apparatus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20070725 |
|
| CX01 | Expiry of patent term |