CN1316896A - Rheology modified compositions and processes thereof - Google Patents

Abstract

Rheology modified compositions, and methods for forming the compositions, are disclosed. The compositions and methods are useful in obtaining desirable properties, including viscosity, in cosmetic, pharmaceutical or household product formulations.

Description

Rheology modified composition and method of making the same

The method that the present invention relates to rheology modified compositions and form said composition.Described compositions and method can be used for comprising in the application of cosmetics, medicine and household products.

Background of invention

For many application, comprise personal nursing, medicine and household products, wish that all applied compositions has the viscosity of hope.Particularly, many application needs for this reason compositions for use have higher relatively viscosity.Rheology can influence such as the stability of the simplicity of the convenience of using, processing, outward appearance aesthetics, product and the character such as retention of used product.

Personal care formulations such as lotion and cream can comprise a large amount of solvents.These prescriptions use oil or softening agent as solvent or main component usually.Make us very much the character of wishing though oil has for cosmetics, as the ability of the property of softening and solvation and makeup removing, the existence of oil is inconvenient for using with fluid form, and also has any problem when application.

Household products such as cleaning product comprise a large amount of oil or wax as solvent or main component.Usually it is desirable for the cleaning product that is applied on surface, the particularly crust can not trickle on described surface before by erasing.Such as the product of furniture polish normally oil or cerul, and should be enough thick, to be retained in applied place, make it possible to finish glazing.

By rheology modified, for example make oily thickening, some do not make us the character of wishing can to reduce or eliminate oil or softening agent.For example, cosmetic formulations can use in thickener composition, as cream, gel or Water-In-Oil or oil-in-water emulsion, particularly water-in-oil emulsion.The preparation of water-in-oil emulsion need be carried out thickening to the oil-continuous phase of Emulsion usually.The thickening of oil phase is at the preparation cosmetic gel, particularly also need during anhydrous gel.

For example, if the component of prescription is responsive to dampness and/or oxygen, then can use the prescription of anhydrous gel form.Some composition in cosmetic or the pharmaceutical formulation is unsettled in water.For example, vitamin C decomposes in water quickly.Therefore, these unsettled compositions can be advantageously with anhydrous formulations for example the form of anhydrous gel provide.Unctuous compositions such as oily dispersion liquid are suitable anhydrous formulations; Yet, except that aforesaid other difficulties relevant with Unctuous compositions, these unsettled compositions in the oiliness prescription, be insoluble or dissolubility relatively poor.

Known polymer can be used as thickening agent or rheology modifier in personal nursing, domestic and drug products field.Yet some polymer might be incompatible with other compositions in the prescription, for example the aromatic in the cosmetic formulations.The thickening of oil also can be finished by the esterification derivative such as the dextrin cetylate that add silicon dioxide, bentonite or fatty acid metal salts such as aluminum salt or sugar.Thickening power also can be finished by add wax in oil phase.But the cream of thickening does not have attracting texture by adding wax, silicon dioxide or bentonite simply or be difficult to use.

The 5th, 318, No. 995 U.S. Patent Publications a kind of method of thickening water-in-oil emulsion, wherein use the copolymer comprise a small amount of ionic or ionizable group.

550, No. 745 European patents of EP disclose the oil phase that the combination of using two kinds of copolymers comes the thickening cosmetic composition.

European patent application has been described the use polyose alkylether for the 795th, No. 322 and has been come the thickened oil based composition and use thereof in packaging.But its disclosed content shows that this method is applicable to that usually some has the oil of the solubility parameter of particular range.

Therefore, still need to be used for the method and composition of the solvent-based formulas of thickening personal nursing, medicine and household products.Also need to have favourable oil nature but the compositions that undesirable character minimizes or do not have.The present invention promptly relates to these aspects and other important aspects.

The invention summary

One aspect of the present invention is a kind of compositions that comprises rheology modifier and solvent mixture, described solvent mixture comprises the hydrogen bonding chemical compound of non-polar oil or wax and compatibility, and wherein said solvent mixture has and is lower than 6.5 joules every cubic centimetre (J/cc) ^1/2The polarity solubility parameter.In preferred embodiments, rheology modifier is a modification of polysaccharides.In a more preferred embodiment, rheology modifier is polysaccharide alkyl, thiazolinyl, alkynyl, aryl, aralkyl or aryl alkenyl ether or their mixture.

Another aspect of the present invention is a kind of compositions that comprises rheology modifier and solvent mixture, and described solvent mixture comprises the non-polar oil of animal, oil or plant origin or the hydrogen bonding chemical compound of wax and compatibility.In preferred embodiments, non-polar oil or wax comprise one or more in following group: the synthesis of derivatives of silicone oil, mineral oil, aliphatic hydrocarbon, native paraffin, pertroleum wax or natural or pertroleum wax.In preferred embodiments, rheology modifier is a modification of polysaccharides.In a more preferred embodiment, rheology modifier is polysaccharide alkyl, thiazolinyl, alkynyl, aryl, aralkyl or aryl alkenyl ether or their mixture.

Another aspect of the present invention is to form method for compositions.This method comprises at room temperature mixes compatibility hydrogen bonding chemical compound and modification of polysaccharides, forms a mixture.In preferred embodiments, rheology modifier is polysaccharide alkyl, thiazolinyl, alkynyl, aryl, aralkyl or aryl alkenyl ether.This mixture at room temperature is placed to the generation solvation.Then non-polar oil or wax are added in the mixture of solvation, form basically compositions uniformly.

Another aspect of the present invention is the method that forms silicone oil composite.This method comprises mixes compatibility hydrogen bonding chemical compound and modification of polysaccharides, adds silicone oil then under the temperature of room temperature or rising, forms basically compositions uniformly.In preferred embodiments, modification of polysaccharides is polysaccharide alkyl, thiazolinyl, alkynyl, aryl, aralkyl or aryl alkenyl ether.

Another aspect of the present invention is a kind of Emulsion, and this Emulsion comprises the hydrogen bonding chemical compound of non-polar oil or wax, rheology modifier and compatibility, and wherein solvent mixture has and is lower than 6.5 (J/cc) ^1/2The polarity solubility parameter.In preferred embodiments, rheology modifier is a modification of polysaccharides.In a more preferred embodiment, rheology modifier is polysaccharide alkyl, thiazolinyl, alkynyl, aryl, aralkyl or aryl alkenyl ether or their mixture.Silicone oil can be oil-in-water type or water-in-oil emulsion.In preferred embodiments, Emulsion is water-in-oil emulsion.

Another aspect of the present invention is a kind of personal care formulations, and this prescription comprises the hydrogen bonding chemical compound of non-polar oil or wax, rheology modifier and compatibility, and wherein solvent mixture has and is lower than 6.5 (J/cc) ^1/2The polarity solubility parameter.In preferred embodiments, rheology modifier is a modification of polysaccharides.In a more preferred embodiment, rheology modifier is polysaccharide alkyl, thiazolinyl, alkynyl, aryl, aralkyl or aryl alkenyl ether or their mixture.This personal care formulations can be used on hair, skin, mucosa and/or the fingernail.

Another aspect of the present invention is a kind of anhydrous formulations, and this anhydrous formulations comprises the hydrogen bonding chemical compound of non-polar oil or wax, rheology modifier and compatibility, and wherein solvent mixture has and is lower than 6.5 (J/cc) ^1/2The polarity solubility parameter.In preferred embodiments, rheology modifier is a modification of polysaccharides.In a more preferred embodiment, rheology modifier is polysaccharide alkyl, thiazolinyl, alkynyl, aryl, aralkyl or aryl alkenyl ether or their mixture.Detailed description of the Invention

The invention provides be used for personal nursing, medicine or domestic and through improved oil compositions, and the method for preparing said composition.Wondrous and find unexpectedly, character such as the viscosity in these compositionss, using rheology modifier and hydrogen bonding chemical compound that compositions is had in desired application, to make us wishing, and reduced simultaneously and in oil compositions, often can observedly not make us the character of wishing.Find unexpectedly that also the compositions and methods of the invention can improve the optical clarity of the compositions that comprises organic solvent and polymer, the reduction of this available turbidity confirms.The unexpected character of another of the present invention's method and composition is when they at room temperature use, can provide through improved character, as viscosity increase and optical clarity increase.That is to say,, unexpectedly find that heating for the uniformity of the present composition and/or transparency not necessarily though for example heating can be advantageously used in the mixing of the component of quickening the present composition.Therefore, compositions of the present invention can at room temperature prepare.

If wish, method and composition of the present invention can provide and at room temperature be solid personal nursing, medicine or household compositions.The present composition and method can reduce the restriction in the process for preparation when using in the preparation solid composite.For example, at room temperature need fast setting usually, guaranteeing uniformity, and deposition is minimized for solid prescription.According to the present invention, these fast setting not necessarily.

Therefore, in one embodiment, the invention provides the method for the optical clarity that improves oil compositions.Personal nursing and other prescriptions that comprise thickening agent often have the muddiness of the amount of not making us wishing.Wondrous and find unexpectedly, be used in combination character such as the viscosity that the hydrogen bonding chemical compound can make compositions have to make us wishing with rheology modifier in personal nursing, medicine and domestic environments, and compare with the thickener composition that does not comprise the hydrogen bonding chemical compound simultaneously and also show muddy the reduction.

In another embodiment, the invention provides and at room temperature forming the method for the oil-based composition comprise polymer viscosity modifier.Wondrous and find unexpectedly, use hydrogen bonding chemical compound such as alcohol, reduce or when having eliminated in oil phase dissolving viscosity modifier to the needs of heat.

Method and composition of the present invention can be used for for example forming anhydrous formulations.These anhydrous formulations can be included in composition unstable in the water, insoluble or that dissolubility is low, and for example vitamin comprises vitamin A, C, D and E.

Comprise the oil formula that contains that all are generally used for nursing and/or protecting skin, hair, fingernail, mucosa, oral cavity or health at this used term " personal care composition ", but they do not have medical treatment or therapeutical effect usually.Comprise cosmetic composition in this used term " personal nursing " compositions.

This used term " household compositions " and " domestic prescription " comprise promising consumer be used to clean, repair, maintain, renovate, beautify, decorate, protect, improve or the sterilize product of dwelling and utensil or interior items, described interior items comprises kitchen and bathroom accessory, furniture, tableware, kitchen tools and clothes.

Comprise the compositions that contains medicine, medicine, medical treatment or treatment product, tonic, food additive, vitamin, mineral etc. at this used term " pharmaceutical composition ", and no matter it is to be used for for oral administration or external.

Comprise at this used term " external " personal nursing or pharmaceutical composition are applied on skin or the mucosa.Comprise with good grounds its effect of institute and be mainly used in prescription and method on the skin in this used term " skin with prescription " or " skin treatment ", and so comprise cosmetics and medicinal application.

Comprise oil at these all terms " oil " derived from mineral, plant and animal.Therefore term oil uses extensively and comprises petroleum oil such as long chain hydrocarbon, and silicone oil.According to oil of the present invention for example is to comprise the chemical compound that has at least about the linearity of 5 carbon atoms or side chain, saturated or unsaturated hydrocarbons alkyl chain, for example has 5,6,7,8 or more a plurality of carbon atom.Therefore, these chemical compounds that comprise at least 8,9,10,11 or 12 carbon atoms, 28,27,26,25,24,23 or 22 carbon atoms of as many as preferred upper limit are according to oil of the present invention.

Be meant at room temperature be solid organic compound at this used term " wax ", the preferred hydrocarbons chemical compound.Except that hydrocarbon, wax also comprises fatty acid-alcohol ester.

Comprise the alkyl that all are saturated at this used term " alkyl ", no matter be straight chain, side chain or cyclic." thiazolinyl " comprises that all contain the alkyl of at least one carbon-to-carbon double bond, no matter be straight chain, side chain or cyclic." alkynyl " comprises that all contain the triple-linked alkyl of at least one carbon one carbon, no matter be straight chain, side chain or cyclic.

Comprise the organic compound that all contain at least one negatron atom such as oxygen, nitrogen or sulfur and can form non-covalent intermolecular bonding by the negatron atom at this used term " hydrogen bonding chemical compound ".Its example comprises alcohol, amine and mercaptan.

In this used term " polarity solubility parameter " representative because the fluid cohesion energy density that dipole-dipole and hydrogen bonding interaction produce.The calculating of this solubility parameter is described in the discussion of following examples 3.

Preferred hydrogen bonding chemical compound is those chemical compounds that comprise one or more hydroxyls according to the present invention.Particularly preferred hydrogen bonding chemical compound is an alcohol.The alcohol that hydrocarbon chain has at least about 8 carbon atoms is preferred, and the alcohol that hydrocarbon chain has at least about 8-32 carbon atom is preferred, and the alcohol that hydrocarbon chain has at least about 10-24 carbon atom is most preferred.Particularly, in cosmetic applications, highly preferred alcohol has 12-24 carbon atom.Overall chain length is that the Guerbet alcohol of 12-32 carbon atom is well known in the art and can be applicable in the personal care applications, and can be used among the present invention.Guerbet alcohol is 2 one alkyl chain triacontanols, as 2 monobutyl capryl alcohol, 2-hexyldecanol, 2-octyldodecanol.The example that is particularly preferred for the alcohol among the present invention is decanol, dodecanol, hexadecanol, stearyl alcohol, butyl capryl alcohol, hexyldecanol and octyldodecanol.If desired, can use the mixture of two or more a plurality of hydrogen bonding chemical compounds, for example Chun mixture.

In the gross weight of the oil phase of compositions, hydrogen bonding chemical compound such as alcohol, the amount in the present composition is about 0.1-60 weight %, is preferably about 0.2-40 weight %, more preferably about 0.3-20 weight %, and most preferably be about 0.5-10 weight %.Preferably, the amount of hydrogen bonding chemical compound is 1-5 weight %, 1-4 weight % more preferably, and most preferably be 1-3 weight %.

According to the present invention, rheology modifier preferably increases the thickening agent of the viscosity of liquid.Rheology modifier comprises synthetic polymer and polysaccharide.Modification of polysaccharides alkyl, thiazolinyl, alkynyl, aryl, aralkyl or aryl alkenyl ether are highly preferred.Modification of polysaccharides alkyl, thiazolinyl, alkynyl, aryl, aralkyl or aryl alkenyl ether can be neutral or charged.

Be used herein to " modification " of describing polysaccharide and comprise polysaccharide alkyl, thiazolinyl, alkynyl, aryl, aralkyl or aryl alkenyl ether, ester, carbamate, amide, carbonic ester, perhaps have the polysaccharide that any other is connected the binding on the polysaccharide skeleton.Modification of polysaccharides can have extra substituent group, and these substituent groups can be cation, anion or nonionic.The example of cationic substituent comprises quaternary ammonium and phosphorus father-in-law.The example of anion substituent comprises carboxyl, phosphate ester, sulfuric ester, carboxyalkyl, sulfo group alkyl and phosphino-alkyl.The substituent example of nonionic comprises alkyl, aryl and hydroxy alkyl.Also can be used as extra substituent group by polysaccharide ether and alkyl ketene dimer or with substituent group that the reaction of alkyl succinic anhydride forms.Extra substituent group can be identical or different, and be selected from first alkyl, thiazolinyl, alkynyl, aryl or aryl alkyl.In modification of polysaccharides, neutral polysaccharide is preferred, and its camber is preferably through the polygalactomannan of modification.Polygalactomannan is well known in the art, and is to comprise as the galactose of polymerized unit and the polymer of mannose.Polygalactomannan is different mutually, particularly aspect galactose and the unitary ratio of mannose.Galactose: the proportional parts of mannose is the source decision according to galactomannan.Polygalactomannan can obtain from several sources, comprises guar gum, tara, fenugreek and locust bean gum.For the present invention, the modification polygalactomannan that is obtained from guar gum is particularly useful, for example alkyl guar gum, particularly ethyl guar.The modification polygalactomannan preferably has the substitution value greater than 2.4.But, in compositions of the present invention and method, can advantageously use other modification polygalactomannan.The synthetic polymer that can be used as rheology modifier comprises acrylate copolymer and copolymer, ethene polymers such as polyvinyl pyrrolidone polymers and copolymer, polyvinyl acetate and oil-soluble polyolefin.

Be meant and be dissolved in the liquid equably at this used term " miscible ".

Be meant the homogeneous phase that in even or non-uniform composition, comprises oil or wax at this used term " oil phase ".For some application, as recognized by those skilled in the art, wax is preferred.For example, the lipstick prescription comprises one or more waxes or solid oil usually.Similarly, in other are used, at room temperature be the oil of liquid preferably.

In compositions of the present invention, oil phase can be included in normally used any oil or oily mixture in personal nursing, domestic and the pharmaceutical formulation.These oil include but not limited to: hydrocarbon comprises mineral oil, as paraffin oil, vaseline, Parleam, linearity or branched-chain hydrocarbons and triglyceride, particularly vegetable oil.The example that is used for the present invention's hydrocarbon-type oil comprises isobutyltrimethylmethane., Fancol ID and 2-Methylpentadecane.The example of vegetable oil comprises that Oleum Helianthi, Oleum sesami, Semen Lini oil, Oleum Verniciae fordii, oiticica oil, Oleum Glycines, Oleum Gossypii semen, Oleum Cocois, Oleum Brassicae campestris, Semen pruni armeniacae oil, Caulis et folium euphorbiae milii oil, Petiolus Trachycarpi oil, American Avocado Tree oil, Jojoba oil, olive oil, Oleum Ricini and corn bud oil are as wheat germ oil.Other oil comprises the various greases that are derived from long chain acid and/or alcohol or polyhydric alcohol, as purcellin oil; Tricaprylin/decanoin; Myristic acid isopropyl, butyl or cetyl ester; Palmic acid isopropyl, butyl or 2-ethyl hexyl ester; Stearic acid isopropyl, butyl, octyl group, cetyl or isocetyl ester; Decyl oleate; Lauric acid hexyl ester; The propylene glycol dicaprylate; The adipic acid diisopropyl ester; And benzoic acid C ₁₂-C ₁₅The mixture of Arrcostab, this mixture can be from Finetex with FINSOLV ^TMTN is that trade name obtains.Following oil also is suitable: animal oil, as perhydro-squalene; And silicone oil, as dimethyl polysiloxane, phenyl dimethyl silscone (methicones), trimethylphenyl silsesquioxane (silsesquioxane), decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, octamethylcy-clotetrasiloxane, dimethyl cyclosiloxane, Cyclomethicone, alkyl dimethyl silicone and their mixture.Silicone oil for example can be commercially available from Dow Coming Corporation.Preferred oil is those oil with about 8 above carbon atoms according to the present invention, and includes but not limited to Jojoba oil, Oleum sesami, Semen Maydis oil, olive oil, safflower oil and Oleum Brassicae campestris; Adeps Bovis seu Bubali resin, and artificial oil, as purcellin oil, Palmic acid 2-ethyl hexyl ester, stearic acid 2-octyl group dodecyl ester, erucic acid 2-octyl group dodecyl ester, isostearic acid iso stearyl ester, benzoic acid 2-octyl group dodecyl ester, the different paraffin of hydrogenation and silicone oil.

According to the present invention, the amount of the rheology modifier needed viscosity of purposes that should be enough to achieve the goal.Generally, in the weight of oil, the amount of rheology modifier is about 0.1-40 weight %, is preferably about 0.3-30 weight %, and more preferably about 0.4-20 weight % most preferably is about 0.5-10 weight %.If compositions is clean compositions, in the weight of oil, the amount of rheology modifier is about 0.5-8 weight %.Be meant the compositions that does not have water basically at this used term " clean compositions ".If compositions is an emulsion type composition, water-in-oil emulsion for example, in the weight of oil, the amount of rheology modifier is about 0.5-10 weight %.Those skilled in the art will appreciate that for concrete personal nursing, domestic or medicinal application the amount of rheology modifier can be partly decides according to the form of compositions.

The compositions and methods of the invention can be used for comprising personal nursing, domestic and drug products in many products.Compositions of the present invention can be a various forms, and for example liquid, gel, solid bar, Emulsion, paste, water/pure liquid or dispersion liquid or ointment form also can randomly be packaged into the aerosol agent or disperse with foamy form.

Compositions of the present invention can comprise various additive as known in the art, comprise other rheology modifier, emulsifying agent, thickening agent, ester as polyacrylic acid, cellulose derivative or fatty acid and Polyethylene Glycol, intercalating agent, Babassuamidopropylamine, antiseptic, spice, electrolyte, lipoid material such as aliphatic alcohol, ceramide and mineral, plant, animal or artificial oil or wax.In the weight of compositions, the amount of additive and other compositions for example can be 0.001-20 weight %.If compositions of the present invention is a personal care composition, then can randomly be included in normally used additive in the personal-care supplies industry, it includes but not limited to active component, spice, antiseptic, fragrant preservative, fragrance release and sunscreen.The application of these additives in the personal care composition and they is well known in the art, and before the oily thickening, during or add with known technology afterwards.Known for those skilled in the art other compositions also can be incorporated in the personal care composition.These compositions comprise fatty ester, 18 β-glycyrrhetinic acid and the ceramide of coloring agent, opacifier, UV screening agent, antioxidant, pearling agent, Biocide, antibacterial, antidandruff agent, antiseborrheic, parasiticide, repellent, dyestuff, pigment, oxidant, Reducing agent, wetting agent, anion, nonionic or cationic polymer, vitamin, 'alpha '-hydroxy acids, tocopherol and ester thereof, ascorbic acid.

If compositions of the present invention is the Emulsion form, then this Emulsion can comprise the normally used any composition of Emulsion in this area, as surfactant and/or dispersing aid.Emulsion also can comprise thickening agent, and it for example is the polymer of water solublity or water-soluble rising property, mainly is included in the aqueous phase that contains of Emulsion.The example of suitable water solublity or water-soluble rising property polymer comprises hydroxyethyl-cellulose, agar, antler glue, pectin, guar gum, hydroxypropyl cellulose, crosslinked acrylic acid polymer and copolymer, Polyethylene Glycol, ethylene oxide polymer and copolymer, caprolactam homopolymer and copolymer, the vinyl methyl ether-be total to-maleic anhydride polymer and polyvinylpyrrolidone of hydroxyethyl-cellulose, hydroxypropyl emthylcellulose, cetyl modification.

Can in compositions of the present invention, mix powder.The example of powder comprises the Magnesiumaluminumsilicate of Chalk, Talcum, Kaolin, starch, terre verte, chemical modification, organically-modified montorillonite clay, aluminium hydrosilicate, fumed silica, octenyl succinic acid starch aluminum and their mixture.

Use the personal care product of compositions of the present invention and method preparation to can be used for various personal nursings, for example skin is handled, as moistening, cleaning, softening, protection, aquation or make skin smooth; Conditioning, softening, cleaning or to hair fixing; Epidermis water is lost to minimize; Conditioning or processing fingernail are perhaps transported various compositions such as sunscreen, vitamin, pigment, dyestuff or coloring agent to hair, skin and/or fingernail.

The personal care product that the present composition and method are suitable for comprises for example wetting agent, and wet tissue is used to clean or the face-cloth of wet skin, make up or remove ornaments and formal dress and use face-cloth, hairspray, skin conditioning agent, hair conditioner, deodorizer, comprise spraying, aerosol, gel and bar-shaped deodorizer, anti-perspirant, comprise spraying, aerosol, gel and bar-shaped anti-perspirant, sun-proof cream or liquid, bating liquor, emulsion or cream, makeup removing cream, liquid or emulsion, foundation cream, be used for artificial tanned liquid, emulsion or cream, the cream that shaves, shaving foam, liquid shaves, palpus back liquid, facial film is used for the cosmetic product of eye, lipstick, lip gloss, the pigment and the foundation cream that are used for face, shampoo, bathing product, the hand cleaning product, and be used for hair dyeing, bleaching, curl, or the compositions of hair straightening.Using in the product of face-cloth such as makeup removing or makeup, compositions of the present invention can be incorporated in and/or be carried on the surface of face-cloth.Other personal care products that the present invention's compositions and method are suitable for comprise dentifrice, tooth cleaning agent, adhesive of tooth, dandruff treatment product, freckle treatment product, wound dressing, wound care and treatment product and oral care product.These personal care products need not to prescribe promptly to be available commercially for consumer usually, and can be used for treating little damage and disease.The personal care product can choose wantonly and comprise active component, as antibacterial, anesthetis and biocides, and can be used on skin or the mucosa, and is included in the cementitious compositions.

Method and composition of the present invention can make using of personal care formulations and use has advantage.For example, the present composition can improve the distribution of various compositions in prescription uniformly basically, transports, comprises the effective or active component of transhipment more equably to hair, skin or fingernail better thus.The example of these active component comprises sunscreen, spice, pigment and other are used for the treatment of the material of skin as described in local as the present invention.Therefore, method and composition of the present invention for example can strengthen the injury that skin or hair are avoided sunlight by transporting sunscreen better.This can be partly according to the absorbent properties of sunscreen in the compositions and/or irradiation absorption composition, strengthen protective effect, and to the protective effect of ultraviolet and/or infrared ray radiation to sunlight.Can expect that also method and composition of the present invention can increase the time of staying of spice on skin thus better to skin transhipment spice.

Method of the present invention also can be used for compositions in the household compositions.In these were used, except that above-mentioned advantage, compositions of the present invention and method can also be transported effectively or active component more equably.

Can use the household products of the present invention's compositions and method to comprise cleaning product, prefinished products, be used to renovate or the product and the sterile products of decorative family.Also comprise pet nursing and dress up and use product." household products " and " household compositions " also comprises the product that is used to clean, repair, decorate or renovate automobile, ship, bicycle or other vehicles, used product during consumer place under repair at home, as the lubricant of be used to saw, bore or polish timber or metal.The lubricant that also comprises home-use machinery or equipment such as sewing machine and other little utensils.The example of cleaning product comprises detergent, rust remover, bleach, glass cleaner, comprises fabric sofetening paper, cloth or sponge, the stove and accessory pretreating agent at fabric softener, the stove and accessory cleaning agent, be used for the cleaning agent of crust such as bathroom device and ceramic tile, furniture detergent and glazing agent, and the cleaning agent or the polishing agent that are used for timber floor.Renovation and decoration comprise lacquer, ink, dyestuff, wood stain, varnish and lac with product.

For household products, except that above-mentioned mention, also can comprise other compositions.For household products, compositions for example can comprise buffer agent, chelating agen, auxiliary dispersants, surfactant, enzyme, fluorescent whitening agent, electrolyte, builder, antioxidant, thickening agent, aromatic, dyestuff, coloring agent, pigment, defoamer or their mixture.Other examples of optional member comprise bleaching scavenger, Dexol, reducing sugar, short chain alcohol, and solvent and hydrotropic agent are as ethanol, isopropyl alcohol and xylene monosulfonic acid; Flow control agent, enzyme stabilizers; Soil suspender; Anti redeposition agent; Anti-tarnishing agent; Anticorrosive; Coloring agent; Grinding agent, and other functional additives.The pH of Cleasing compositions can regulate by adding strong acid or alkali.Described buffer agent comprises sodium carbonate and sodium borate.

But compositions of the present invention and method be the drug application field also.The application of drug world is usually directed to the transhipment of medicine or other pharmacological actives.Be meant any chemistry or the biological substance that may produce desirable biology or pharmacological action at this used term " medicine " or " pharmacological actives " or any similar term, described effect comprises that (1) influences life process, (2) organism had preventive effect, and prevent undesirable biological agent, for example protect from infection, (3) treatment disease, comprise the disease that alleviation is caused by disease, for example alleviate pain or inflammation that disease causes, and/or alleviate, reduce or eliminate fully the disease of organism.Therefore, medicinal application comprises the disease that is used for the treatment of skin or the material of other diseases, and described disease or disease for example are rash, and fungus, virus or bacterial infection are chapped, decortication, burn, damage and dermatitis.Can comprise compositions of the present invention or prepared according to the methods of the invention prescription by use and come that the pharmaceutical actives of administration comprises antibacterial, anesthetis, vitamin and/or mineral, particularly those are because vitamin and/or mineral that medical reasons is left and the medicine that is used for the treatment of disease.Comprise the pharmaceutical composition of the present composition to patient's administration of needs treatments, can finish thus treatment of diseases.Described administration comprises oral administration, topical or passes through the suppository administration.

In medicinal application, compositions can comprise acceptable additive, component, carrier, extender, filler, processing aid and excipient on the materia medica known in the art.Term " acceptable excipient on the materia medica " comprises any solvent, disperse medium, coating materials and absorption delay agent.Therefore, compositions of the present invention can comprise known conventional excipients in the pharmaceutical field, as thickening agent, emulsifying agent, flavoring agent, coloring agent etc.

The example of the present composition and method medicinal application applicatory comprises the prescription that is used to swallow and is used for the prescription of topical application.The pharmaceutical formulation of swallowing that the present invention is suitable for comprises the dosage form such as capsule, flat capsule, tablet, liquid and gel.The pharmaceutical formulation of the topical that the present invention is suitable for comprises emulsifiable paste, washing liquid, gel, alite paste, ointment and the preparation that is used for the transdermal administration pharmaceutically active substance.For transdermal administration, helping chemical intensifier and other additives that medicine sees through skin or mucosa transhipment can be included in the said composition.

Except that the above, by following description, various improvement of the present invention are conspicuous to those skilled in the art.These improve also within the scope of the appended claims.

Embodiment

Following examples only are to be used to illustrate the present invention, and should never be interpreted as and limit the scope of the present invention.According to open and appended claims of the present invention, these embodiment and equivalent thereof will be more apparent to those skilled in the art.

Embodiment 1

Measure by turbidimetry and to comprise alkyl galactomannans--the optical clarity of the mixture of N-Hance_AG-200 polymer (Hercules Incorporated).This mixture is the mixture of N-Hance_AG-200/ alcohol/organic solvent, the polymer (AG-200), alcohol (dodecanol or hexadecanol) and organic solvent (the Finsolv TN that wherein mix various concentration, Palmic acid isopropyl esters, perhaps 50:50 Finsolv TN: the Palmic acid isopropyl esters).Mixture is prepared as follows: at first mix the solvent composition (annotate: hexadecanol and spermol at room temperature are solid) of suitable weight, add the N-Hance_AG-200 alkyl galactomannans of suitable weight then.With mixture heated to 70-85 ℃ about 1 hour, to accelerate the dissolving of polymer.Use the turbidity of Orbeco-Hellige 966 type transmissometer working samples.Sample is included in Wheaton-property glass scintillation bottle.The turbidity data see Table 1.

Table 1

50:50 Finsolv TN: Palmic acid isopropyl esters T (NTU) T (NTU) Wt% polymer Wt% polymer
											The % dodecanol	???0.5	????1	????2	????3		The % hexadecanol	????0.5	?1	?2	?3
											????0.0	???10.2	?11.9	?24.2	?50.8		????0.0	????10.2	?11.9	?24.2	?50.8
????1.0	???10.1	?11.5	?23.5	?35.6		????0.5	????9.7	?12.3	?27.1	?35.9
											????2.0	???9.5	?11.8	?23.4	?35.3		????1.0	????9.7	?12.6	?27.0	?35.9
????5.0	???5.8	?10.8	?22.7	?33.2		????1.5	????9.5	?11.8	?26.6	?35.6
											????10.0	???5.5	?10.2	?21.2	?32.1		????2.0	????8.9	?12.1	?26.7	?35.4
The Palmic acid isopropyl esters
											The % dodecanol	???0.5	?1	??2	????3		The % hexadecanol	????0.5	?1	?2	?3
											????0.0	???8.5	?18.4	?38.0	?58.1		????0.0	????8.5	?18.4	?38.0	?58.1
????1.0	???8.2	?17.2	?37.2	?555.33		????0.5	????10.0	?19.5	?43.3	?57.5
											????2.0	???8.2	?17.4	?36.2	?54.4		????1.0	????10.0	?18.9	?37.9	?56.1
????5.0	???7.4	?15.8	?33.5	?50.8		????1.5	????9.7	?19.0	?35.4	?55.3
											????1?0.0	???6.7	?13.8	?29.2	?46.5		????2.0	????9.5	?18.5	?37.0	?54.4
????????????????????????????????Finsolv?TN
											The % dodecanol	???0.5	??1	?2	????3		The % hexadecanol	????0.5	?1	?2	?3
											????0.0	???4.6	?10.2	?22.5	?34.5		????0.0	????4.6	?10.2	?22.5	?34.5
????1.0	???4.7	?10.0	?21.9	?34.5		????0.5	????4.6	?10.8	?22.0	?32.9
											????2.0	???4.?5	?9.9	?21.2	?33.7		????1.0	????4.9	?10.7	?22.0	?33.6
????5.0	???4.4	?9.0	?19.6	?31.5		????1.5	????5.2	?11.2	?22.0	?33.2
											????10.0	???4.0	?8.1	?17.7	?28.4		????20	????4.5	?10.9	?21.5	?33.0

From the data of table 1 as can be seen, along with the increase of polymer concentration, the turbidity of gained solution also increases.Also can be clear that, add the turbidity that long-chain alcohol can reduce gained solution, produce result more attractive in appearance.

Embodiment 2

The mixture of preparation N-Hance_AG-200 polymer or N-Hance_AG-50 polymer and decanol leaves standstill then.When leaving standstill, polymer is by alcohol height swelling.When polymer concentration is low, the complete swelling of solute, and when high concentration, still keep the polymer of excessive not solvation.The results are shown in Table 2.Table 2:N-Hance_AG polymer/decanol swelling and absorption

The Wt% polymer	The Wt% decanol	Outward appearance N-Hance_AG-50 system	Outward appearance N-Hance_AG-200 system
				10	?90	Phase under clear gel/sticky polymers (40), fluid solvent upper strata (60)	Phase under clear gel/sticky polymers (60), fluid solvent upper strata (40)
20	?80	Phase under clear gel/sticky polymers (70), fluid solvent upper strata (30)	Clear gel/sticky polymers phase is upwards rarer in polymer
				30	?70	Clear gel/sticky polymers phase is upwards rarer in polymer	Clear gel/sticky polymers phase
40	?60	Clear gel/sticky polymers phase	Clear gel/sticky polymers phase, the polymer of very small amount of excessive not solvation
				50	?50	Clear gel/sticky polymers phase, the polymer of a spot of excessive not solvation	Clear gel/sticky polymers phase, the polymer of the excessive not solvation of appreciable amount
60	?40	Clear gel/sticky polymers phase, the polymer of the excessive not solvation of appreciable amount	Clear gel/sticky polymers phase, the polymer of a large amount of excessive not solvations

70	?30	Clear gel/sticky polymers phase, the polymer of a large amount of excessive not solvations	Clear gel/sticky polymers phase, the polymer of a large amount of excessive not solvations
				80	?20	Clear gel/sticky polymers phase, the polymer of a large amount of excessive not solvations	Clear gel/sticky polymers phase, the polymer of a large amount of excessive not solvations
90	?10	Clear gel/sticky polymers phase, the polymer of a large amount of excessive not solvations	Clear gel/sticky polymers phase, the polymer of a large amount of excessive not solvations

The above results shows, can prepare the gel or the viscosity solution that comprise 30-40 weight % polymer.

Embodiment 3 carries out the viscosity modification with the N-Hance_AG polymer to solvent in the presence of alcohol

The solution (25wt%N-Hance_AG 50 polymer or 20wt%N-Hance_AG200 polymer) of preparation N-Hance_AG polymer in 2-butyl capryl alcohol.The polymer solutions of accurate weighing 1 or 2 grams in scintillation vial.Accurately weighing adds the 0 or 2 2-butyl capryl alcohol that restrain in each bottle.

Accurately weighing adds primary solvent in each bottle, makes final total volume be about 20 milliliters.At this used primary solvent be: DC-345 (Dow Corning, cyclomethicone), DC-556 (Dow Corning, phenyl trimethyl silicone), P-99A (Permethyl Specialties, Fancol ID), P-101A (Permethyl Specialties, 2-Methylpentadecane).With magnetic stirrer mixed solvent, polymer and alcohol, go up heating 1 hour at heating plate (95 ℃) then, form the polymer of 1-1.5 and 2-2.5 weight % nominal concentration, the 2-butyl capryl alcohol of 2-10 and 12-24 weight % concentration.

Use has Brookfield LVDV-II+viscometer of small sample adapter and #18 axle and measures solution viscosity.Each sample of 8 milliliters is added in the sample cell of viscometer, then at 25 ℃ of following constant temperature.The axle speed of rotation is set in the speed of rotation maximum in the rod reading.

Use the direct measuring samples turbidity of Orbeco-Hellige transmissometer.

Use the volume fraction rule of mixture to calculate solubility parameter (δ _{D, mix}=φ _{2-butyl capryl alcohol}δ _{D, 2-butyl capryl alcohol}+ φ _{Primary solvent}δ _{D, primary solvent}δ _{P, mix}=φ _{2-butyl capryl alcohol}δ _{P, 2-butyl capryl alcohol}+ φ _{Primary solvent}δ _{P, primary solvent}).The solubility parameter of used component is listed in the table 4.The turbidity of each compositions, viscosity and outward appearance are listed in the table 3.Solubility parameter is described in C.M.Hansen, and " The Three-dimensionalSolubility Parameters ", J.Paint Technol., the 39th rolls up in 105 pages (1967).

Table 3

Primary solvent	Polymer	The Wt.% primary solvent	The Wt.% polymer	Wt.% 2-butyl capryl alcohol	?δ d?(J/cc) 1/4	δ Doler(J/cc) 1/2	Turbidity (NTU)	Viscosity (cP)	Explanation
										DC-345							????2.0	????5.4
DC-556							????0.7	????25.4
										1-12							????0.4	????29.7
P-99A							????0.33	????4.3
										P-101A							????0.4	????6.0
DC-345	AG-50	????95.1	????1.2	????3.7	????15.2	????0.4	????5.9	????6.8	There is the obviously undissolved solid of amount
										DC-345	AG-50	????84.7	????1.3	????14.0	????15.3	????1.6	????44.2	????22.6	Homogeneous solution
DC-345	AG-50	????90.3	????2.4	????7.2	????15.3	????0.8	????180.0	????82.2	Homogeneous solution
										DC-345	AG-50	????81.6	????2.3	????16.2	????15.4	????1.8	????65.7	????68.9	Homogeneous solution
DC-556	AG-50	????94.7	????1.3	????3.9	????17.1	????0.5	????7.2	????71.3	Homogeneous solution
										DC-556	AG-50	????84.4	????1.3	????14.3	????17.0	????1.6	????7.4	????72.3	Homogeneous solution
DC-556	AG-50	????90.0	????2.5	????7.5	????17.1	????0.9	????15.8	????223.2	Homogeneous solution
										DC-556	AG-50	????80.2	????2.5	????17.3	????17.0	????2.0	????15.6	????237.6	Homogeneous solution
P-99A	AG-50	????92.6	????1.8	????5.5	????15.9	????0.5	????37.8	????10.4	There is a small amount of undissolved solid
										P-99A	AG-50	????81.8	????1.6	????16.7	????15.9	????1.5	????11.6	????12.2	Homogeneous solution
P-99A	AG-50	????87.7	????3.1	????9.2	????15.9	????0.8	????31.6	????24.9	Homogeneous solution
										P-99A	AG-50	????76.4	????3.0	????20.6	????15.9	????1.9	????21.5	????26.5	Homogeneous solution
P-101A	AG-50	????93.6	????1.6	????4.8	????16.6	????0.5	????16.6	????15.9	Homogeneous solution
										P-101A	AG-50	????80.8	????1.6	????17.6	????16.5	????1.7	????11.0	????19.5	Homogeneous solution
P-101A	AG-50	????87.4	????3.1	????9.4	????16.6	????0.9	????28.4	????55.0	Homogeneous solution
										P-101A	AG-50	????75.4	????2.9	????21.7	????16.5	????2.1	????18.8	????52.6	Homogeneous solution
DC-345	AG-200	????94.1	????1.2	????4.7	????15.2	????0.5	????245.0	????31.6	There is the undissolved solid of appreciable amount
										DC-345	AG-200	????84.9	????1.0	????14.1	????15.3	????1.5	????39.4	????32.3	There is a small amount of undissolved solid
DC-345	?AG-200	????89.1	????2.2	????8.7	????15.3	????0.9	????150.4	????152?7	Homogeneous solution
										DC-345	AG-200	????80.0	????2.0	????18.0	????15.4	????2.0	????60.5	????116.7	Homogeneous solution
DC-556	AG-200	????94.5	????1.1	????4.4	????17.1	????0.5	????9.1	????135.0	Homogeneous solution
										DC-556	AG-200	????85.5	????1.0	????13.5	????17.0	????1.5	????8.3	????102.0	Homogeneous solution

Table 3 (continuing)

Primary solvent	Polymer	The Wt.% primary solvent	The Wt.% polymer	Wt% 2-butyl capryl alcohol	????δ d(J/cc) 1/2	??δ Doler?(J/cc) 1/2	Turbidity (NTU)	Viscosity (cP)	Explanation
										DC-556	AG-200	????90.0	????2.0	????8.0	????17.1	????0.9	????14.8	????514.0	Homogeneous solution
DC-556	AG-200	????81.1	????1.9	????17.0	????17.0	????1.9	????13.8	????366.0	Homogeneous solution
										P-99A	AG-200	????93.1	????1.4	????5.6	????15.9	????0.5	????21.3	????10.0	Homogeneous solution
P-99A	AG-200	????80.6	????1.3	????18.1	????15.9	????1.6	????10.4	????13.5	Homogeneous solution
										P-99A	AG-200	????86.1	????2.8	????11.1	????15.9	????1.0	????28.8	????52.2	Homogeneous solution
P-99A	AG-200	????73.4	????2.7	????23.9	????15.9	????2.2	????21.9	????69.5	Homogeneous solution
										P-101A	AG-200	????93.0	????1.4	????5.6	????16.6	????0.5	????16.8	????40.5	Homogeneous solution
P-101A	AG-200	????78.6	????1.5	????19.8	????16.5	????1.9	????12.0	????41.2	Homogeneous solution
										P-101A	AG-200	????88.1	????2.4	????9.5	????16.6	????0.9	????25.3	????84.9	Homogeneous solution
P-101A	AG-200	????76.6	????2.3	????21.1	????16.5	????2.0	????17.7	????98.1	Homogeneous solution

" AG-200 "=N-Hance_AG 200 alkyl galactomannans polymer; " AG-50 "=N-Hance_AG 50 alkyl galactomannans polymer.The solubility parameter of solvent for use among table 4 embodiment 3

Solvent	????δ Always????(J/cc) 1/2	????δ d????(J/cc) 1/2	????δ p????(J/cc) 1/2	Density (g/cc)
					Dow?Corning DC-345	????15.2	????15.2	????0	????0.96
Dow?Corning DC-556	????17.2	????17.2	????0	????0.98
					Fancol ID (Permethyl 99A)	????15.9	????15.9	????0	????0.747
2-Methylpentadecane (Permethyl P-101A)	????16.6	????16.6	????0	????0.79
					2-butyl capryl alcohol (Jarcol 1-12)	????17.0	????16.12	????9.78	????0.833
2-hexyldecanol (Isofol 16)	????17.0	????16.26	????8.55	????0.836

React the δ of DC-345 and DC-556 based on dimethylsiloxane polymer and with respect to the solvatochromism of the linear dimethyl siloxane of low-molecular-weight of linear and cyclic alkane _pValue is 0 (to see J.E.Brady, D.Bjorkman, C.D.Herter, P.W.Carr; Analytical chemistry (1984) 56,278-83 page or leaf and the list of references of wherein quoting).δ _dValue is to be calculated by the liquid refractive index that measures, and wherein uses following relational expression: δ _d=62.78 * (n ²-1)/(n ²+ 2) (J/cc) ^1/2, wherein n is the refractive index of neat liquid.The solubility parameter of 2-butyl capryl alcohol and 2-hexyldecanol obtains in the 332A1 European patent from the 0th, 795.

δ _Always=(δ _d+ δ _p) ^1/2=(/ Δ E _Vap/ V) ^1/2, δ wherein _Always, δ _dAnd δ _pBe respectively total, dispersion and polarity solubility parameter.

The soft gel of embodiment 4 preparation gel anti-perspirant water-in-oil type anti-perspirants

Part	Composition	Weight %
			?A	REACH? 301 solution (a)	35.0
?B	Deionized water	21.0
			?C	Cyclomethicone and dimethyl silscone copolyol (b)	20.0
?D	Glycerol 99.7%	20.0
			?E	Natrosol?250MR?CS	0.25
?F	N-Hance_AG	1.00
			?G	The 2-hexyldecanol	3.00

(a) Reheis, Inc. (b) Silsoft MSC (OSI Specialties) method: 1, E is added among the B.PH is increased to 8.5.Mixed 30 minutes.Add D.Mixed 30 minutes.2, A is made an addition in the pre-composition of preparation in step 1, mixed 15 minutes.3, be added among the C with the pre-composition of slower speed preparation in the step 2 very slowly.4, mixed 15 minutes.5, mixed F and G totally 30 minutes.Very slowly add in the pre-composition that is preparation in the step 4 with slower speed.

Embodiment 5 preparation abrasive tumbling formula (roll-on) anti-perspirants 1, contrast composition (weight %3 * g)

A, Tetrachlorohydrex zirconium aluminum GLY powder (Rezal 36 GP SUF, Reheis)	20.0	?60.0
			B, Cyclomethicone and Quatemium-18 Hercolite and SDA 4 (Bentone Gel VS-5/PC, RHEOX)	13.5	?40.5
C, Cyclomethicone (Dow Corning 244)	66.0	?198.0
			D, silicon dioxide (Sylox15, W.R.Grace)	0.5	?1.5
E, spice	qs	?0.0
			???????????????????????????????????????????????????????????????100.0g??????????300.0

Contrast used method: program #1 X31651-67-1A1, make " B " and " C ", " E " reach " F " to mix 20 minutes.2, add " A " and mixed 15 minutes.3, add " D " and mixed 10 minutes.4, homogenize 3 minutes in 4 ounces of jars.II, abrasive tumbling formula anti-perspirant produced according to the present invention

Have the anti-perspirant suspension abrasive tumbling agent of N-Hance_AG polymer

Composition (weight %3 * g)

A, Tetrachlorohydrex zirconium aluminum GLY powder (Rezal 36 GP SUF Reheis)	16.0	?48.0
			B, Cyclomethicone and Quatemium-18 Hercolite and SDA 4 (Bentone Gel VS-5/PC, RHEOX)	13.0	?39.0
C, Cyclomethicone (Dow Corning 244)	66.0	?198.0
			(Sylox 15, W.R.Grace) for D, silicon dioxide	0.5	?1.5
E, spice	qs	?0.0
			F, N-Hance_AG 1.0 3.0 2-hexyldecanol 3.0 9.0
?????????????????????????????????????????????????????????????100.0?g?????????300.0

Method: 1, make " B " and " F " reach " C " and mixed 20 minutes.2, add " A " and mixed 15 minutes.3, add " D " and mixed 10 minutes.4, homogenize 3 minutes in 4 ounces of jars.

Embodiment 6 preparation liquid soaps

Opaque liquid soap prescription

Composition	Weight %
		Water	75.73
C14-C16 alkene sulfonic acid sodium, 40% activity	7.50
		Sodium N-lauroyl sarcosinate, 30% activity	6.66
Cocoamide base CAB, 35% activity	6.66
		The glycol stearate	1.00
?Natrosol_Plus?330	0.80??
		Propylene glycol	0.50
Glycerol	0.50
		EDTA four sodium	0.30
Stearalkonium chlorine	0.10
		Methyl butex	0.25
?????????????????????????????????????????????????????????100.00

Method: 1, NP330 is scattered in the water.PH is increased to about 8.0-8.5,, mixed then 45 minutes with dissolve polymer.In final solution, add methyl butex.2, under slowly stirring, add water-soluble polymer solution, Stearalkonium chlorine, alkene sulfonate and glycol stearate.With mixture heated to 80 ℃, until all glycol stearate fusions, and solution becomes opaque.3, add residual components, simultaneously solution is slowly cooled to room temperature.4, add pigment and spice.

Embodiment 8 preparation soap prescriptions

The hand soaps prescription

Composition	Weight %
		Water	65.70
C14-C16 alkene sulfonic acid sodium	20.00
		Sodium N-lauroyl sarcosinate	10.00
Cocoamide MEA	3.00
		?Natrosol_250HR	1.00
The EDTA disodium	0.20
		Methyl butex	0.10
?????????????????????????????????????????????????????100.00

Method: 1, Natrosol 250HR product is dispersed in the water.PH is increased to about 8.0-8.5,, mixed then 45 minutes with dissolve polymer.In final solution, add methyl butex.2, mixed surfactant in independent container is heated to 80 ℃, is mixed to then evenly.3, surfactant solution is added in the water-soluble polymer solution, and is mixed to evenly.4, add the EDTA disodium, be cooled to room temperature then.The source and the description of used product in liquid soap and the hand soaps prescription

The title that common name or CTFA adopt	Trade name	Supplier
			Stearalkonium chlorine Northfield.Illinois	?Ammonyx?4002	?Stepan?Chemical?Co.
C14-C16 alkene sulfonic acid sodium Northfield.Illinois	?Bio-Terge?AS-40	?Stepan?Chemical?Co.
			Sodium N-lauroyl sarcosinate	?Hamposyl?L-30	?W.R.Grace&Company ?Nashua,New?Hampshire
Cocoamide base CAB	?Lexaine?C	?Inolex?Chemical?Company ?Philadelphia,Pennsylvaina
			Cocoamide MEA Paterson, New Jersey	?MonamidCMA	?Mona?Industries?Inc.
EDTA four sodium Northfield, Illinois	?Perma?Kleer100	?Stepan?Chemical?Co.
			Hydroxyethyl-cellulose	?Natrosol?250HR ?N-Hance_AG	?Hercules?Incorporated ?Hercules?Incorporated

Embodiment 9 preparation conditioner prescription health-hair conditioning agent prescriptions

Composition	Weight %
		Natrosol_250HR	1.0
Water	74.1
		Cetrimonium chlorine (25%)	12.2
Lauryl amine oxide (30%)	10.2
		Polyquatemium-17(62％)	1.5
Polypropylene glycol	1.0
		Spice, antiseptic	To 100.0

Method: 1, under good stirring, Natrosol is dispersed in the water.PH is increased to about 8.0-8.5, with dissolve polymer, mixed then 45 minutes or until fully the dissolving.2, press said sequence and add residual components, and when each the interpolation, well mix.

Embodiment 10 preparation rinsing emulsion formulations

Pearly-lustre rinsing emulsion formulations

Composition		Weight %
			Phase A	?Natrosol_Plus?330	?1.00
?Natrosol?250HHR	?0.30
		Water		82.30

			Phase B	Stearalkonium chlorine (25%)	10.10
Propylene glycol	1.50
		Phenyl trimethyl silicone		1.45
Alkyl galactomannans	0.01
		2-butyl capryl alcohol		0.04
?Oleth-20	1.50
		?Polyquatemium-17(62％)		1.80
Spice, antiseptic	To 100.00

Method: 1, under good stirring, NP330 and Natrosol 250HHR are dispersed in the water.PH is increased to about 8.0-8.5,, is mixed to dissolving fully then with dissolve polymer.2, in independent container, mix stearalkonium chlorine and propylene glycol, be heated to 80 ℃ then.3, according to said sequence other listed among phase B compositions are added in the mixture of stearalkonium chlorine and propylene glycol, and when each the interpolation, well mix.4, surfactant mixture is added in the HMHECl solution, the good mixing, is cooled to 35 ℃ then.5, add spice and antiseptic then, form end formulation.Used raw material and source thereof in health-hair conditioner and the pearly-lustre rinsing emulsion formulations

The title that common name or CTFA adopt	Trade name	Supplier
			Quateminm-48	Adogen?470	?Sherex?Chemical?Co.,Inc. ?Dublin,Ohio
?Oleth-20	Emulphor?ON-870	?Rhone-Poulenc ?Cranbury,New?Jersey
			Hydrolyzed animal protein	Lexein?X-250	?Inolex?Chemical?Company ?Philadelphia,PA
?Polyquatemium-17	Mirapol?AD-1	?Rhone-Poulenc ?Cranbury,New?Jersey
			Cocoamide base propylamine oxide	AmmonyxCDO	?Stepan?Company ?Northfield,Illinois
Lauryl amine oxide	Ammonyx?LO	?Stepan?Company ?Northfield,Illinois
			Cetrimonium chlorine	Varisoft?E228	?Sherex?Chemical?Co.,Inc. ?Dublin,Ohio
Stearalkonium chlorine	Varisoft?SDC	?Sherex?Chemical?Co.,Inc. ?Dublin,Ohio
			Modification HEC	Natrosol_Plus?330	?Hercules?Incorporated ?Wilmington,Delaware
Hydroxyethyl-cellulose	Natrosol?250HHR	?Hercules?Incorporated

Embodiment 11 preparation hands and health washing liquids

Composition		Weight %
			A、	Natrosol_Plus?330	?0.50
Distilled water	78.25
		Glycerol, USP		?2.00

?B、	Glycol stearate (Emerest 2400)	2.75
			N-Hance_AG	0.50
	Stearic acid (Industrene 5016K)	2.50
			Mineral oil (Drakeol7)	2.00
	Acetylated lanolin (Lipolan 98)	0.50
			Spermol (Crodacol C95)	0.25
?C、				Distilled water	9.50
	Triethanolamine	0.50
?D、	Propylene glycol and diazolidinyl urea and methyl butex and propylparaben (Germaben II)	0.75
			???????????????????????????????????????????????????????????????????100.00

Method: 1, in the A part, NP 330 is dispersed in the water of stirring.Add glycerol, and mix continuously, be heated to 80 ℃ then.Mixed 15 minutes down at 80 ℃.2, in independent container, mix each composition in the B part.With mixture heated to 80 ℃, mix then.3, under good the stirring, the A part slowly is added in the B part.The temperature of emulsion is maintained at about 80 ℃, and stirs consistently.4, each composition in the mixed C part is added in the emulsion then.Continue to mix, be cooled to 40 ℃ simultaneously.5, in emulsion, add D part (antiseptic), well mix then.6, the cooling emulsion is contained in the container then.Material that hands and body wash are used and supplier

The title that CTFA adopts	Trade name	Supplier
				HMHEC4	?Hercules?Incorporated ?Wilmington,Delaware
The glycol stearate	Emerest?2400	?Henkel?Corporation ?Hoboken,NJ
			Stearic acid	Industrine?5016K	?Witco?Corporation ?Newark,NJ
Mineral oil	Drakeol?7	?Penreco. ?Kams?City,NJ
			Acetylated lanolin	Lipolan?98	?Lipo?chemicals ?Patterson,NJ
Spermol	Crodacol?C95	?Croda?Inc. ?Parsippany,NJ
			Hydroxyethyl-cellulose	Natrosol?250MR	?Hercules?Incorporated
Modification HEC		?Natrosol_Plus?330 ?Hercules?Incorporated

Breast shaves

Composition	Amount, g
		Deionized water	790.0
Sodium hydroxide (24.6% solution)	9.6
		Potassium hydroxide (34.2% solution)	34.2
Stearic acid, two pressures are crossed	71.6
		Coconut acid	10.0
Propylene glycol	27.0

Lauramide DEA	?10.0
		Oleum Cocois	?2.0
N-Hance_AG	?0.5
		Adeps Bovis seu Bubali glyceride	?30.0
Antiseptic (Germaben II)	?5.0
		Natrosol_250HR	?10.0
Amount to	?1000.0

Method:

For the preparation newborn concentrate that shaves, in a container, under room temperature, sodium hydroxide and potassium hydroxide are added in the deionized water.Temperature with container is increased to 75 ℃ then, and stirs 5 minutes.Pre-fusion stearic acid and coconut acid are added on respectively in alkali/aqueous mixtures then separately, stir 30 minutes, are cooled to 55 ℃ then.Natrosol 250HR is suspended in the propylene glycol, is added in the said mixture then.Next once lauramide DEA (fused), Oleum Cocois, Adeps Bovis seu Bubali glyceride (fused), N-Hance AG and antiseptic are added in the described container, stirred then 15 minutes, then place cooling.

Concentrate is transferred in another container.For aerosol cream, in 12 ounces of breast jars that shave of standard, add 225g.Seal this jar with the laboratory caging unit with valving then, and charge into the propellant of 9.0g.

The composition of the newborn usefulness that shaves and supplier

The title that CTFA adopts	Trade name	Supplier
				HMHEC3	?Hercules?Incorporated ?Wilmington,Delaware
Stearic acid	Industrene?5016	?Witco?Corporation ?Mempbis,Tennessee
			Coconut acid	Industrene?328	?Witco?Corporation ?Memphis,Tennessee
Lauramide DEA	Standamid?LD	?Henkel?Corporation ?Ambler,Pennsylvania
			Oleum Cocois	Oleum Cocois	?Sigma?Chemical?Co. ?St.Louis.Missouri
Adeps Bovis seu Bubali glyceride	Peacock?Acidless?Tallow	?Geo.Pfau?s?SonsCo. ?Jeffersonville,Indiana
			Sorbitol	Sorbo (70% activity)	?ICI?Americas,Inc. ?Wilmington,Delaware
Propylene glycol (with) diazolidinyl urea (with) methyl butex (with) propylparaben	GermabenⅡ	?Sutton?Laboratories ?Chatham,New?Jersey
			88/12 iso-butane/propane	The A-46 propellant	?Aeropres?Corporation ?Shreveport,Louisiana
Propylene glycol	Propylene glycol	?Eastman?Chemical?Co. ?Rochester,New?York
			Hydroxyethyl-cellulose	Natrosol_250HR N-Hance_AG	?Hercules?Incorporated ?Hercules?Incorporated

The standard emulsus toothpaste that contains HMHEC2

Composition		Weight %
			Ⅰ、	Natrosol_250?HNF	?0.75 1
Glycerol 100%	12.50
		N-Hance_AG		?0.50
Sorbitol (70% solid)	16.86
		Distilled water		14.71 2
			Ⅱ、	Dicalcium phosphate, anhydrous	45.00
			?Ⅲ、	Tetrasodium pyrophosphate (TSPP)	0.42
Saccharin sodium	0.20
		Sodium monofluorophosphate (SMFP)		0.76
Sodium benzoate	0.50
		Distilled water		6.25
			?Ⅳ、	Flavoring agent	0.55
Sodium lauryl sulfate	1.00
		????????????????????????????????????????????????????????????????100.00

1: proofread and correct polymer weight 2: for water: regulate the water yield method that is used for the polymer water content with respect to water content: 1, in container, the salt in the part III is made an addition in the water, stirs simultaneously, be heated to then about 60 ℃ to carry out pyrolysis.During heating cover this container, to prevent losing of water branch.2, for the part I, weighing glycerol also is added in the beaker, then polymer Natrosol N-Hance AG is dispersed in the glycerol, simultaneously stir about 5 minutes or until abundant dispersion.Add sorbitol, and continued to stir the mixture 10 minutes.Add water, and restir 15-30 minute, to guarantee the complete hydration of polymer (gel-free).Add the saline solution of temperature, and continue to stir 15 minutes or until evenly (no piece or gel).This mixture is transferred in the toothpaste blender (Ross double planetary mixer).3, for the part II, in blender, add DCP and water, under slower speed, mix 10 minutes then with complete moistening DCP.Open blender then, scrape pasty mixture from blade and mixer wall.The sealing blender, and apply vacuum.Blender ran up under vacuum 20 minutes or had level and smooth denseness until pasty mixture.4,, SLS is added in the blender, then mixed on low speed 5 minutes under no vacuum for the part IV.In blender, add flavoring agent, and under low speed, mixed 2 minutes.Open blender then, blade and mixer wall are swiped.The sealing blender applies vacuum, mixes 15 minutes under the medium speed then, observes foam.5, close blender, and break vacuum, take out the product of paste then.Gel

Composition	Weight %	Weight (g)
			A、N-Hance_AG	?2.00	?8.00
B, phenyl trimethyl silicone	90.00	?360.00
			C, 2-butyl capryl alcohol	8.00	?32.00
???????????????????????????????????100.00?????????????????????????400.00

Method: 1, in the mixture of " A ", " B " and " C ", add N-Hance AG.2, temperature is increased to 90 ℃ then, and mixed 1 hour.3, be cooled to room temperature, stir simultaneously.4, add the antiseptic methyl butex, and mixed 10 minutes.5, be distributed in the container.Gel

Use Dow Corning 345 to substitute phenyl trimethyl silicone.Adhesive of tooth

Adhesive of tooth according to one 100 gram batch of following formulation:

Mineral oil	?20.0
		Vaseline	?30.0
HMHEC2	?47.0
		N-Hance_AG	?3.0
	?100.0

Method:

In the beaker of 250ml, be metered into vaseline and mineral oil.This beaker is placed in the circulation oil bath that is heated to 67 ℃.Use the electronics blender to stir content with speed 0, the diameter of this blender is 1.5 inches, and blade is spaced apart 0.25 inch in the rotating shaft.When the temperature of content is 65 ℃, slowly add polymer, regulate the speed of blender simultaneously, to keep the eddy current in the mixture.Continue to mix 1 hour.Transparent bar-shaped anti-perspirant

Followingly prepare transparent bar-shaped anti-perspirant with two phase process.Phase 1:

Be not added in the reaction vessel 65% (not comprising in the antiperspirant salts solution part) of used propylene glycol total amount.In this container, add Klucel_GF, be stirred to dissolving then.Heat this container with dissolve polymer.After the polymer dissolution, solution is heated to 110-115 ℃ immediately, adds dibenzyl sorbitol then, and be mixed to dissolving fully.This phase I solution is cooled to about 100 ℃ then.The phase II:

Be not added in another container 35% (not comprising in the antiperspirant salts solution part) of used propylene glycol total amount, stir and be heated to about 60-70 ℃ then.Add EDTA four sodium and be mixed to the formation homogeneous slurry.Next in this container, add antiperspirant salts solution, and it is transparent and even until becoming to stir this solution.Add softening agent--dimethyl-silicon ketone copolymers, it is transparent to becoming to mix this phase II solution then.Mixed phase:

Under agitation the phase II is added in the phase I, is cooled to 80 ℃ then.Randomly, add aromatic and fully mixing at this moment.Product is poured onto 1 ounce of jar, the cooling of spending the night then.Spend the night the cooling after, the physics of test sample and chemical property.Device therefor:

The glass beaker of 2 400ml, oil bath, clip, mechanical agitator, Jiffy agitator and thermometer, and antipollution lid such as plastics package paper.Total prescription of this embodiment:

1, propylene glycol	?46.67g
		2、Al/Zrtetrachlorohydrate-gly	?36.60g *
3, dibenzyl sorbitol	?0.50g
		4、Klucel?GF	?0.30g
5, EDTA sodium	?0.20g
		6, phenyl trimethyl silicone	?3.00g
7、N-Hance_AG	?0.05g
		8,2-hexyldecanol	?0.20g
	?87.52g

*: 30% living solution phase I:

Polypropylene glycol	?32.07g
		Dibenzyl sorbitol	?0.50g
Klucel_GF	?0.30g
			?32.87g

The phase II:

Polypropylene glycol	14.60g
		Al/Zr?tetyachlorohydrate-gly	36.60g
EDTA sodium	0.20g
		Phenyl trimethyl silicone	3.00g
N-Hance_AG	0.05g
		The 2-hexyldecanol	0.20g
	54.65g

Transparent bar-shaped anti-perspirant

Use DC-345 (cyclomethicone) to substitute phenyl trimethyl silicone (DC-556).

Raw material that bar-shaped anti-perspirant is used and supplier thereof

Raw material	Supplier
		Propylene glycol (USP level)	?EM?Science ?Gibbstown,NJ
Al/Zrtetrachlorohydrate-gly Westchlor A2Z 8160 30%PG solution	?Westwood?Chernical?Corporation ?Middletown,New?York
		Dibenzyl sorbitol Millithix 925	?Milliken?Chemical
Klucel_GF	?Hercules?Incorporated ?Wilmington,DE
		Cyclomethicone DC-345	?Dow?Corning
EDTA sodium, Aldrich#5403EJ	?Aldrich?Chemical?Company ?Milwaukee,Wisconsin
		Phenyl trimethyl silicone DC-556	?Dow?Corning

Pearly shampoo

Composition	Weight %	Weight (g)
			Distilled water	To 100.00	?347.25
TEA-lauryl sulfate (40% activity) (Stepanol WAT)	15.00	?75.00
			Lauroamphoacetate sodium (with) tridecyl sodium sulfate (Miranol MHT)	10.00	?50.00
Cocoamide DEA (Ninol40C0)	2.50	?12.50
			Glycol stearate (Emerest 2400)	1.20	?6.00
Propylene glycol (with) diazolidinyl urea (with) methyl butex (with) propylparaben (Germaben II)	0.75	?3.75
			Natrosol_250HHR	?0.60	?3.00
N-Hance_AG	?0.50	?2.50
			Citric acid (50% solution)	PH regulator	?--
	100.00	?500.00

Method: 1, in container, N-Hance_ is dispersed in the water of stirring.With citric acid solution pH is reduced to 7.0, to promote the dissolving of surface-treated N-Hance.Be heated to 50 ℃.2, Natrosol slowly is sieved in the N-Hance solution, is mixed to dissolving fully then.3, temperature is increased to 70 ℃.Disposable interpolation TEALS and glycol stearate.Between each adds, fully mix.In case evenly, just stop heating immediately.Continue to stir.4, when temperature reaches 55 ℃, the remaining composition of disposable interpolation.5, being adjusted to pH with citric acid solution is 5.0.6, be cooled to 40 ℃, add aromatic then.The composition of pearly shampoo and supplier thereof

The title that CTFA adopts	Trade name	Supplier
			The TEA-lauryl sulfate	Stepanol?WAT	?Stepan?Company ?Nothfield.Illinois
Lauroamphoacetate sodium (with) tridecyl sodium sulfate	Miranol?MHT	?Rhone-Poulenc ?Cranbury,NJ
			Cocoamide DEA Nothfield, IL	Ninol?40C0	?Stepan?Company
The glycol stearate	Emerest?2400	?Henkel?Corporation ?Hoboken,NJ
			Propylene glycol (with) diazolidinyl urea (with) methyl butex (with) propylparaben	GermabenⅡ	?Sutton?Lab ?Chatham,NJ
Alkyl galactomannans	N-Hance_AG	?Hercules?Incorporated ?Wilmington,DE
			Hydroxyethyl-cellulose	Natrosol_250HHR	?Hercules?Incorporated

Suntan lotion

Composition		Weight %	Weight (g)
				A	The 2-hexyldecanol	0.50	?2.50
Mineral oil (Klearol, Witco)	13.00	?65.00
			Polyoxypropylene 15 stearyl ether (Arlamol E, ICI)		6.00	?30.00
Octyl methoxycinnamate (Neo Heliopan AV, H﹠R)	5.00	?25.00
			Benzophenone-3 (Uvinul M40 BASF)		3.00	?15.00
Castor oil hydrogenated (Castor Wax, Ross)	1.40	?7.00
			(Arlacel 987, ICI) for anhydro sorbitol list isostearate		1.20	?6.00
The polyoxyethylene polyols fatty acid ester (Arlatone T, ICI)	1.00	?5.00
			Ozokerite wax (O Wax 77W, Ross)		1.00	?5.00
(Arlacel 989, ICI) for polyoxyethylene fatty acid ester	0.50	?2.50
?B	?N-Hance_AG	?0.50					?2.50
			Distilled water	63.60	?318.00
	Glycerol	2.50				?12.50
			Magnesium sulfate	0.70	?3.50
	Diazolidinyl urea, PG, methyl butex, propylparaben (the Germaben II, ISP)	0.10				?0.50
			??????????????????????????????????????????????????????????????????100.00???????500.00

Method: 1, the used composition among the mixing portion A.2, temperature is increased to 70 ℃, stirred 30 minutes.3,, N-Hance AG is dispersed in the water for part B.Make the pH value of serosity be increased to 8.5 with sodium hydroxide.Be mixed to dissolving.Under agitation disposable adding glycerol, magnesium sulfate and antiseptic.Between adding, each fully mixes, to guarantee not having piece to form.4, under agitation lentamente part B is added in the part A.5, stirred 30 minutes down at 70 ℃.6, under agitation be cooled to room temperature.7, be filled in the container.Suntan lotion

Mineral oil with cyclomethicone (DC-345) alternative 50%.The raw material of suntan lotion and supplier thereof

The title that CTFA adopts	Trade name	Supplier
			Mineral oil	Klearol	?Witco?Corporation ?Dublin.OH
Polyoxypropylene 15 stearyl ether	Arlamol?E	?ICI?Surfactants ?Wilmington,DE
			Octyl methoxycinnamate	NeoHeliopanAV	?H&R?Corporation ?Springfield,NJ
Benzophenone-3	Uvinul?M40	?BASF?Corporation ?Washington.NJ
			Castor oil hydrogenated	Castor wax	?Ross
Anhydro sorbitol list isostearate	Arlacel?987	?ICI?Surfactants
			The polyoxyethylene polyols fatty acid ester	Arlatone?T	?ICI?Surfactants
Ozokerite wax	O?Wax?77W	?Ross
			Polyoxyethylene fatty acid ester	Arlacel?989	?ICI?Surfactants
?N-Hance_AG		?Hercules?Incorporated ?Wilmington,DE
			Diazolidinyl urea, PG, methyl butex, propylparaben	GermabenⅡ	?Sutton?Lab ?Chatham,NJ

Water-pure abrasive tumbling agent

Part	Composition	Weight %	Weight (g)
				A	REACH 501 solution (50%Al chlorohydrate)	39.00	?156.00
?B	Procetyl?AWS(PPG-5?ceteth-20)	2.00	?8.00
				?C	HMHEC4	0.20	?0.80
?D	Deionized water	15.70	?62.80
				?E	AD alcohol 40	41.10	?164.40
?F	N-Hance_Ag	1.00	?4.00
				?G	Aromatic (d)	1.00	?4.00
???????????????????????????????????????????????????????100.00??????????????400.00

Method: 1, HMHEC4 is dispersed among the D.Make pH be increased to 8.5 with sodium hydroxide solution.Mixed 30 minutes.2, add A gradually.Use the top to stir and carry out rapid mixing, with dissolving.3, in independent container, mix B, E and F, under constant agitation, slowly be added in the remaining batch of material then.4, add aromatic.Mixed 5 minutes.5, be poured onto in the abrasive tumbling container.The material and the supplier thereof of water-pure abrasive tumbling agent

The title that CTFA adopts	Trade name	Supplier
			Al?chlorohydrate	REACH?501	?Rehies?Incorporation ?Berkeley?Height,NJ
?PPG-5?ceteth-20	Procetyl?AWS	?Croda?Incorporation ?Parsippany,NJ
				HMHEC4	?Hercules?Incorporated ?Wilmington,DE
Ethanol	SD alcohol 4
			Aromatic Classic oriental/spice	#Q-7148 ?Fragrances?Inc.	?Quest?International ?Mount?Olive,NJ
Hydroxyethyl-cellulose	Natrosol_250MRCS	?Hercules?Incorporated ?Wilmington,DE
			Alkyl galactomannans	N-Hance_AG	?Hercules?Incorporated

Shower gels

Composition		Weight %	Weight (g)
				A	Deionized water	To 100.00	?276.60
?B	?Natrosol_250?HR	?0.95	?4.75
				?C	Sodium lauryl sulfate (Steol CS460, Stepan)	11.53	?57.65
Lauryl sulfosuccinic disodium (Stepan Mild SL3, Stepan)	11.80	?59.00
			The Cocoamphodiacetate disodium (Miranol C2M Conc NP, Rhone-Poulenc)		6.00	?30.00
Sodium N-lauroyl sarcosinate (Crodasinic LS30, Croda)	7.25	?36.25
			Propylene glycol		2.00	?10.00
Quaternized wheat protein (WheataFlor, Croda)	1.00	?5.00
			Hydrolysate and through the wheat protein of hydrolysis and wheat germ oil ﹠ Spheron MD 30/70 20 glycol distearates and Laureth-4 and CAPB (Euperlan PK 3000, Henkel)		2.00	?10.00
The EDTA disodium (EDETABD, BASF)	0.10	?0.50
			(Drom 229033, Drom) for spice		0.35	?1.75
Phenyl phenol and methyl butex and oxybenzene Ethyl formate and propylparaben and oxybenzene butyl formate (Phinonip, Nipa)	0.60	?3.00
			Phenyl trimethyl silicone (DC-556)		1.00	?5.00
?N-Hance_AG	0.02	?0.10
			The 2-hexyldecanol		0.08	?0.40
????????????????????????????????????????????????????????????????100.00?????????500.00

Method: 1, under agitation Natrosol is dispersed in the water.2, make the pH of serosity be increased to 8.5 with sodium hydroxide solution.It is even to be mixed to solution.Add the composition of phase C then according to said sequence.Between each the interpolation, mixed 1 minute or until evenly.3, with the pH regulator of end product to 5.3-5.7.4, be filled in the container.Raw material that bath gels is used and supplier thereof

The title that CTFA adopts	Trade name	Supplier
			Guar gum hydroxypropyl trimonium chlorine	N-Hance_3196	?Hercules?Incorporated ?Wilmington,DE
Sodium lauryl sulfate	Steol?CS460	?Stepan?Company ?Northfield,NJ
			The lauryl disodium sulfosuccinate	Stepan?Mild?SL3	?Stepan?Company
The Cocoamphodiacetate disodium	Miranol?C2M?ConeNP	?Rhone-Poulenc ?Cranbury,NJ
			Sodium N-lauroyl sarcosinate	Crodasinic?LS30	?Croda?Incorporated ?Parsiparmy,NJ
Quaternized wheat protein	WheataFlor	?Croda?Incorporated
			Hydrolysate and through wheat protein and wheat germ oil ﹠ Spheron MD 30/70 glycol distearate and the Laureth-4 and the CAPB of hydrolysis	?Euperlan?PK?3000	?Henkel?Corporation ?Hoboken,NJ
The EDTA disodium	EDETA?BD	?BASF?Corporation ?Washington,NJ
			Spice	Drom?229033	?Drom?International ?Towaco,NJ
Phenyl phenol and methyl butex and oxybenzene Ethyl formate and propylparaben and oxybenzene butyl formate	Phinonip	?Nipa?Hardwick?Inc. Wilmington,DE

Guar gum hydroxypropyl trimonium chlorine	N-Hance?3196	?Hercules?Incorporated ?Wilmington,DE
			Phenyl trimethyl silicone	DC-556	?Dow?Corning

The cosmetic breast that contains sunscreen

Composition		Trade name/supplier	Weight %
				Phase A	Cyclomethicone (with) dimethyl silscone copolyol	Dow Corning_3225C, shaping assistant	?6.0
Decyl oleate	Ceraphyl?140/VanDyk	?2.5
			Octyldimethyl PABA			?2.0
Tristerin S.E.	CerasyntQ/VanDyk	?1.0
			Stearic acid, through triple compactings			?2.0
Myristyl myristate		?1.0
			Ermine wax			?1.3
Alkyl galactomannans	N-Hance?AG-200/Hercules	?0.2
Phase B	Water						?57.3
			Antiseptic	Dowcil?200/Dow?Chemical ?Co.	?0.2
	?PEG-8					?5.0
			?Glycereth-26	?Liponic?EG-l/Lipo	?5.0
	Four hydroxypropyl ethylene diamines	Quadro/BASF				?0.5
Phase C	Pigment grind material (13% ferrum oxide, 40% titanium dioxide, 47% Kaolin)						?10.0
			Bentonite	Volclay,Superfine	?3.0
	?Supper?Pearl?100	?Mearl				?3.0
			?????????????????????????????????????????????????????????????????????????????????100.00

Method:

Make pigment grind material micronization, add remaining phase C composition then.Mixed phase C and B mutually.Under 78 ℃ (158 °F), phase B is added among the phase A with the mixture of C mutually, uses cage blender or sidespin (side-sweep) blender to mix simultaneously.Stir cooling down at 28 ℃ (82 °F).Liquid make-up

Composition		Trade name/supplier	Weight %
				Phase A	Cyclomethicone	Dow?Coming_344	?10.0
Ceraphyl 140A	Ceraphyl?140A/Van?Dyk	?2.7
			Stearoyl-oxy trimethyl silane and stearyl alcohol		Dow?Commg?580?Wax	?2.5
Stearic acid		?2.0
			Glyceryl monostearate S.E.		Cerasynt?Q/Van?Dyk	?1.0
Semen sojae atricolor stearol	Generol?122/Henkel	?0.4
			Alkyl galactomannans		N-Hance?AG-200/Hercules	?0.2
				Phase B	Water		?56.0
	?PEG-8	Polyglycol?E-400	?5.0
					?Glycereth-26	Liponic?EG-l/Lipo	?5.0
	Four hydroxypropyl ethylene diamines	Quadro/BASF	?0.5
					Antiseptic		?0.2
	Pigment grind material (13% ferrum oxide, 40% titanium dioxide, 47% Kaolin)		?14.5
				???????????????????????????????????????????????????????????????????????????????????100.00

Method:

Make pigment grind material micronization, add remaining phase B composition then.Individually phase A is heated to 75 ℃ (167 °F) with B mutually, mixes with cage blender or sidespin blender simultaneously.Cooling under mixing.At 48 ℃ (118) following product thickness that begins to become, then in about 38 ℃ (100) packing down.Make up and cover rod (cover stick)

Composition		Trade name/supplier	Weight %
				Phase A	Stearmide MEA	?Monamid?S/Mona	?18.6
Stearmide MEA stearate	Witcamide?MAS/Witco	?8.3
			The 2-octyldodecanol			?2.0
				Phase B	Alkyl galactomannans	N-Hance?AG-200/Hercules	?8.5
Mineral oil		?25.0
			Vaseline			?4.0
The PPG-3 myristicin	Witconol?APM/Witco	?8.0
			The pigment grind material			?25.0
				Phase C	Antiseptic		?0.1
Aromatic		?q.s.
			??????????????????????????????????????????????????????????????????????????????100.00

Method:

Down with dasher mixed phase B composition, be heated to 80 ℃ (176 °F) at 50 ℃ (122 °F) then.Phase A is heated to 80 ℃ (176 °F), is added into then among the phase B, and be mixed to evenly.Temperature is reduced to 60 ℃ (140 °F), adds phase C then.Cast in the bar-shaped mould, be cooled to room temperature then.The hair dressing agent

Composition	Trade name/supplier	Weight %
					?A	?B	?C
		Alkyl galactomannans	N-Hance?AG-200/Hercules					?0.5
The phenyl dimethyl silscone	Dow Coming_556 fluid					?7.5	?5.0
		Dimethyl silscone copolyol	Dow Coming_193 surfactant	?5.0
Vaseline	Sonojell#9/Witco				?31.0	?25.0	?31.0
		Mineral oil	Klearol/Witco	?23.0				?25.0
Mineral oil and lanolin oil	Nimelesterol?D/EmeryInd.				?47.0
		Paraffin						?12.0
Microwax	Amber?Wax/Bareco				?12.0		?13.0
		Lanoline		?25.0				?25.0
Ermine wax	Mink?Wax/Emulan?Inc.				?4.0		?4.0
		The myristic acid isopropyl esters	Emerest?2314/Emery?Ind.					?5.0
Aromatic					?q.s.	?q.s.	?q.s.
				?100				?100	?100

Method: prescription A-heating vaseline and microwax are until fusion.Add remaining composition.Prescription B-heating vaseline and microwax are until fusion.Add remaining composition.Prescription C-makes microwax, vaseline and the fusion together of ermine wax.In independent container, mix Nimelesterol and Dow Corning 556 fluids.Be added in first mixture.Eye shadow rod substrate

Composition	Trade name/supplier	Weight %
			Alkyl galactomannans	N-Hance_AG-200/Hercules	?0.5
Cyclomethicone	Dow Corning_345 fluid	?29.5
			Lanolin oil	Fluilan/Croda	?6.7
Brazil wax	Brazil wax/Strahl﹠Pitsch	?8.0
			Cera Flava	Cera Flava, white/Strahl﹠Pitsch	?3.3
Mineral oil	Carnation/Witco	?22.7
			Spermol	Adol?52/Sherex?Chemical?Co.	?2.7
Pigment		?26.6
			?????????????????????????????????????????????????????????????????????100.0

Method:

Mix all wax and oil, be heated to all fusions of all wax then.To be added in the substrate through the pigment that grinds.Be poured onto in the mould.The emulsus lipstick

Composition	Trade name/supplier	Weight %
			The pigment grind material
Titanium dioxide		4.0
			Pigment		3.4
Oleum Ricini		25.0
			Wax-matrix
Trimethyl silyloxy esters of silicon acis (with) stearyl alcohol	Dow?Corning_580?Wax	4.5
			Myristyl myristate		7.0
Octyldodecanol		2.0
			Lanolin oil		7.0
Alkyl galactomannans	N-Hance_AG-200/Hercules	1.0
			Candelilla wax		5.5
Cera Flava USP		4.5
			Brazil wax		2.5
?Ozokerite(76℃)		3.5
			American Avocado Tree oil		29.6
Propylene glycol (with) tertiary butylated hydroquinone (with) citric acid	Tenox?20/Eastman	0.1
			Antiseptic	Propylparaben	0.1
?DC?Red?21		0.15
			Aromatic		1.0
?????????????????????????????????????????????????????????????????????????????100.85

Method:

In advance DC Red 21 and aromatic are dissolved in the siloxane wax.Be metered into other compositions, be heated to 80 ℃ (176 °F) then, make the wax fusion.Add the siloxane wax/aromatic blend under 80 ℃ (176), and be poured onto in the mould.Before taking out club, mold cools down should be avoided the pulverizing of rod.Soft dose of hair (relaxer)

Composition		Trade name/supplier	Weight %
					?A	?B
			Phase A	Trimethyl silyl-Amo dimethyl silscone			Dow Corning_Q2-8220 conditioning additive or Dow Corning_ X2-8230	?2.0	?2.0
	Alkyl galactomannans	N-Hance_AG-200/Hercules			?0.5	?0.5
				Emulsifing wax			Polawax/Croda	?7.0	?7.0
	Spermol	Adol?52/Sherex?Chemical?Co.			?1.0	?1.0
				Vaseline			Protopet?White?IS/Witco Sonneborn	?4.0	?4.0
	Mineral oil	Camation/Witco?Sonneborn			?15.0	?15.0
Phase B	Water							?64.5	?64.5
			Propylene glycol		?2.0	?2.0
Phase C						Sodium hydroxide (50%)		?4.0	?4.0
	???????????????????????????????????????????????????????????????????????????100.0?????100.0

Method:

Heat phase A and B to 72 ℃ mutually (161) respectively.Under agitation lentamente phase B is added among the phase A.Add phase C.Homogenize.Sachet

Composition		Trade name/supplier	Weight %
				Phase A	Cyclomethicone (with) dimethyl silscone copolyol	Dow Corning_3225C shaping assistant	45.0
Stearyl alcohol		3.5
			Glycerol three (behenic acid) ester		Syncrowax?HR-C/Croda	11.0
Alkyl galactomannans	N-Hance_AG-200/Hercules	1.0
			Isofol-16 (2-hexyldecanol)			3.0
Phase B	Water						17.5
			Phase C	Aromatic		10.0
?????????????????????????????????????????????????????????????????????????????????100.0

Method:

Mix separately and heating oil phase and water to 75 ℃ (167).Under agitation lentamente water is added in the oil phase.Stirring is cooled to 55 ℃ (131 °F), and adds aromatic.Need heat to fill.Must be packaged in the container of sealing.Not spiced product is about 55 ℃ (131) fusions.Add spice and will reduce this fusing point.Water-in-silicone type antiperspirant spray

Composition		Trade name/supplier	Weight %
				Phase A	Isofol-16		2.0
Cyclomethicone	Dow Corning_345 fluid	33.0
			Mineral oil			2.0
Phenyl trimethyl silicone	Dow Corning_556 fluid	5.0
			Cyclomethicone (with) dimethyl silscone copolyol		Dow Corning_3225C shaping assistant	7.9
Alkyl galactomannans	N-Hance_AG-200/Hercules	0.1
			Phase B		Spheron MD 30/70 20	Tween?20/ICI	1.0
Aluminum Chlorohydrate (with) water		49.0
				?????????????????????????????????????????????????????????????????????????????????100.0

Method:

Mixed phase A composition is measured the phase refractive index then in suitable containers.In independent container, mixed phase B composition is measured the phase refractive index then.Suitably regulate the refractive index of phase A.When refractive index match, under moderate shear,, slowly be added among the phase B then with Gifford-Wood Eppenbach blender and A mutually.After all phase B add, shear this emulsion to even.Suggestion uses the high speed one way to shear, to improve stability.Transparent water-in-silicone type antiperspirant abrasive tumbling agent

Composition		Trade name/supplier	Weight %
				Phase A	Cyclomethicone	Dow Corning_344 fluid	20.0
Cyclomethicone (with) dimethyl silscone copolyol	Dow Corning_3225C shaping assistant	8.0
			Alkyl galactomannans		N-Hance_AG-200/Hercules	0.5
Isofol-16		1.5
Phase B	Aluminum zirconium Chlorohydrex-Gly (with) water						58.0
			Water		3.3
	Propylene glycol					8.7
			?????????????????????????????????????????????????????????????????????????????????100.0

Method:

Mixed phase A composition is measured the phase refractive index then in suitable containers.In independent container, mixed phase B composition is measured the phase refractive index then.Adding propylene glycol increases refractive index or adds water and reduce refractive index, and the refractive index of regulating phase B thus makes it be complementary with the refractive index of A mutually.When refractive index match, under moderate shear,, slowly be added among the phase B then with Gifford-Wood Eppenbach blender and A mutually.After all phase B add, shear this emulsion to even.

Claims (59)

1, a kind of compositions that comprises rheology modifier and solvent mixture, described solvent mixture comprises the hydrogen bonding chemical compound of non-polar oil or wax and compatibility, the polarity solubility parameter of wherein said solvent mixture is lower than 6.5 (J/cc) ^1/2

2, compositions as claimed in claim 1, wherein non-polar oil or wax are selected from following group: the synthesis of derivatives of silicone oil, mineral oil, aliphatic hydrocarbon, native paraffin, pertroleum wax and natural or pertroleum wax.

3, compositions as claimed in claim 1, wherein rheology modifier is a modification of polysaccharides.

4, compositions as claimed in claim 3, wherein rheology modifier is to comprise the polysaccharide that is selected from the group in following group: alkyl, thiazolinyl, alkynyl, aryl, aralkyl and aryl alkenyl.

5, compositions as claimed in claim 4, wherein said group are to be connected on the polysaccharide skeleton by the key that is selected from following group: ether, ester, carbamate, amide and carbonic ester.

6, compositions as claimed in claim 3, wherein modification of polysaccharides is the modification galactomannan.

7, compositions as claimed in claim 6, wherein the modification galactomannan is an ethyl guar.

8, compositions as claimed in claim 1, wherein the polarity solubility parameter of solvent mixture is lower than about 4.

9, compositions as claimed in claim 1, wherein the polarity solubility parameter of solvent mixture is lower than about 2.

10, compositions as claimed in claim 1, wherein the polarity solubility parameter of solvent mixture is lower than about 1.

11, compositions as claimed in claim 1, wherein the polarity solubility parameter of solvent mixture is lower than about 1.

12, a kind of emulsion, it comprises compositions as claimed in claim 1.

13, a kind of compositions that is used to handle skin, it comprises compositions as claimed in claim 1.

14, compositions as claimed in claim 13, it further comprises at least a material that is selected from following group: sunscreen, vitamin, pigment, wetting agent, skin conditioning agent, fragrant preservative and fragrance release.

15, a kind of method of handling skin, it is included in and uses the cosmetic formulations that comprises compositions as claimed in claim 1 on the skin.

16, a kind of method that is used to strengthen to the protective action of sunlight, it is included in and uses the compositions that comprises compositions as claimed in claim 1 on the skin.

17, a kind ofly be used to make transdermal water to lose minimized method, it is included in and uses the compositions that comprises compositions as claimed in claim 1 on the skin.

18, a kind of cosmetic composition that comprises compositions as claimed in claim 1, wherein said hydrogen bonding chemical compound are alcohol.

19, compositions as claimed in claim 18, wherein alcohol is the 2-alkyl chain triacontanol.

20, compositions as claimed in claim 1, its described hydrogen bonding chemical compound is an amine.

21, compositions as claimed in claim 1, its described hydrogen bonding chemical compound is a mercaptan.

22, a kind of oral care composition, it comprises compositions as claimed in claim 1.

23, a kind of dentifrice, it comprises compositions as claimed in claim 1.

24, a kind of adhesive of tooth, it comprises compositions as claimed in claim 1.

25, a kind of face-cloth of making up or removing ornaments and formal dress of being used to, it comprises compositions as claimed in claim 1.

26, a kind ofly be used to clean or the face-cloth of wet skin, it comprises compositions as claimed in claim 1.

27, a kind of method for the treatment of disease, it comprises that the patient's administration to the needs treatment comprises the pharmaceutical composition of compositions as claimed in claim 1.

28, method as claimed in claim 27, wherein said disease is a dermatosis.

29, method as claimed in claim 28, the wherein described compositions of topical.

30, a kind of wound dressing, it comprises compositions as claimed in claim 1.

31, a kind of anti-perspirant or deodorant compositions, it comprises compositions as claimed in claim 1.

32, compositions as claimed in claim 31, wherein anti-perspirant or deodorizer are the form of transparent or opaque rod.

33, compositions as claimed in claim 31, wherein anti-perspirant or deodorizer are the forms of spray, aerosol or abrasive tumbling agent.

34, a kind of anhydrous composition is comprising at least a vitamin and compositions as claimed in claim 1.

35, a kind of cementitious compositions, it comprises compositions as claimed in claim 1.

36, a kind of lipstick or lip gloss, it comprises compositions as claimed in claim 1.

37, a kind of liquid cosmetic composition, it comprises compositions as claimed in claim 1.

38, a kind of sunscreen composition, it comprises compositions as claimed in claim 1.

39, a kind of hair care composition, it comprises compositions as claimed in claim 1.

40, a kind of skin care compositions and methods, it comprises compositions as claimed in claim 1.

41, a kind of ointment that comprises anesthetis, antibacterial or biocide, it comprises compositions as claimed in claim 1.

42, a kind of pharmaceutical composition that comprises acceptable carrier on medicine and the materia medica, it comprises compositions as claimed in claim 1.

43, compositions as claimed in claim 42, it is the form of tablet or capsule.

44, a kind of method that increases the retention time of aromatic on skin, it is included in and uses the compositions that comprises aromatic and compositions as claimed in claim 1 on the skin.

45, a kind of formation method for compositions, it comprises:

At room temperature mix compatibility hydrogen bonding chemical compound and rheology modifier, form mixture,

Said mixture is at room temperature placed, until the generation solvation, and

Non-polar oil or wax are added in the mixture of own solvation, form basically compositions uniformly.

46, method as claimed in claim 44, wherein non-polar oil or wax are selected from following group: the synthesis of derivatives of silicone oil, mineral oil, aliphatic hydrocarbon, native paraffin, pertroleum wax and natural or pertroleum wax.

47, method as claimed in claim 44, wherein rheology modifier ether is modification of polysaccharides.

48, method as claimed in claim 46, wherein modification of polysaccharides is to comprise the polysaccharide that is selected from the group in following group: alkyl, thiazolinyl, alkynyl, aryl, aralkyl and aryl alkenyl.

49, method as claimed in claim 47, wherein said group are to be connected on the polysaccharide skeleton by the key that is selected from following group: ether, ester, carbamate, amide and carbonic ester.

50, method as claimed in claim 47, wherein modification of polysaccharides is the modification galactomannan.

51, method as claimed in claim 49, wherein the modification galactomannan is an ethyl guar.

52 1 kinds form method for compositions, and it comprises:

Mix compatibility hydrogen bonding chemical compound and polysaccharide alkyl, thiazolinyl, alkynyl, aryl, aralkyl and aryl alkenyl ether; At room temperature add silicone oil then, form basically compositions uniformly.

53, method as claimed in claim 51, wherein non-polar oil or wax are selected from following group: the synthesis of derivatives of silicone oil, mineral oil, aliphatic hydrocarbon, native paraffin, pertroleum wax and natural or pertroleum wax.

54, method as claimed in claim 51, wherein rheology modifier ether is modification of polysaccharides.

55, method as claimed in claim 53, wherein modification of polysaccharides is to comprise the polysaccharide that is selected from the group in following group: alkyl, thiazolinyl, alkynyl, aryl, aralkyl and aryl alkenyl.

56, method as claimed in claim 54, wherein said group are to be connected on the polysaccharide skeleton by the key that is selected from following group: ether, ester, carbamate, amide and carbonic ester.

57, method as claimed in claim 53, wherein modification of polysaccharides is the modification galactomannan.

58, method as claimed in claim 56, wherein the modification galactomannan is an ethyl guar.

59, a kind of composition for ink, it comprises compositions as claimed in claim 1.