CN1309422C - Nanometer particle and medicine capsule of polymeric compound and preparation - Google Patents
Nanometer particle and medicine capsule of polymeric compound and preparation Download PDFInfo
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- CN1309422C CN1309422C CNB2005100605749A CN200510060574A CN1309422C CN 1309422 C CN1309422 C CN 1309422C CN B2005100605749 A CNB2005100605749 A CN B2005100605749A CN 200510060574 A CN200510060574 A CN 200510060574A CN 1309422 C CN1309422 C CN 1309422C
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- Prior art keywords
- chitosan
- nanoparticle
- polyvinyl alcohol
- polylactic acid
- water
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- 239000003814 drug Substances 0.000 title claims abstract description 38
- 229920000642 polymer Polymers 0.000 title claims abstract description 21
- 239000002775 capsule Substances 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000002245 particle Substances 0.000 title claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 40
- 239000003381 stabilizer Substances 0.000 claims abstract description 37
- 238000000034 method Methods 0.000 claims abstract description 29
- 239000000203 mixture Substances 0.000 claims abstract description 29
- 229920000747 poly(lactic acid) Polymers 0.000 claims abstract description 28
- 239000004626 polylactic acid Substances 0.000 claims abstract description 28
- 229920002521 macromolecule Polymers 0.000 claims abstract description 15
- 239000007787 solid Substances 0.000 claims abstract description 11
- 239000002105 nanoparticle Substances 0.000 claims description 63
- 229920001661 Chitosan Polymers 0.000 claims description 34
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 30
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 29
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 29
- 239000000243 solution Substances 0.000 claims description 27
- 238000004945 emulsification Methods 0.000 claims description 25
- 238000003756 stirring Methods 0.000 claims description 15
- 229940126586 small molecule drug Drugs 0.000 claims description 12
- 229920002988 biodegradable polymer Polymers 0.000 claims description 8
- 239000004621 biodegradable polymer Substances 0.000 claims description 8
- 239000005517 L01XE01 - Imatinib Substances 0.000 claims description 7
- 229940080856 gleevec Drugs 0.000 claims description 7
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims description 7
- 238000007789 sealing Methods 0.000 claims description 6
- 239000003960 organic solvent Substances 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 230000002045 lasting effect Effects 0.000 claims description 3
- 239000002088 nanocapsule Substances 0.000 claims description 2
- 230000015556 catabolic process Effects 0.000 abstract description 6
- 238000006731 degradation reaction Methods 0.000 abstract description 6
- 229940079593 drug Drugs 0.000 abstract description 5
- 229920000867 polyelectrolyte Polymers 0.000 abstract description 5
- 239000004094 surface-active agent Substances 0.000 abstract description 4
- 238000005516 engineering process Methods 0.000 abstract description 3
- 230000001804 emulsifying effect Effects 0.000 abstract description 2
- 150000003384 small molecules Chemical class 0.000 abstract 2
- 238000013019 agitation Methods 0.000 abstract 1
- 241001597008 Nomeidae Species 0.000 description 9
- 238000000053 physical method Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a polymer nanometer particle, a medicine capsule and the preparation thereof. The polymer nanometer particle is composed of the following components: 85 to 95 wt% of degradation type high molecules composed of polylactic acid and a derivative thereof, and 5 to 15 wt% of surface stabilizing agent macromolecules composed of a non-ionic macromolecule surfactant and other polyelectrolyte mixtures. A degradation type macromolecule solution is added into the water containing a surface stabilizing agent to form a water-in-oil structure. After the agitation of one hour, a milky solution is obtained. Finally, the nanometer particle can be obtained by an ultrasonic emulsifying method. The medicine capsule is formed by that water-soluble small molecule medicines are sealed in the nanometer particles composed of the degradation type high molecules and the surface stabilizing agent macromolecules, and the solid content of the small molecule medicines in the nanometer particles is from 1 to 10%. As a result, the present invention has the characteristics that the present invention has simple preparation technology and reduces preparation cost; besides, the present invention can perfectly control the mechanism of degradation and release, greatly widen the application area, etc.
Description
Technical field
What the present invention relates to is a kind of Biodegradable polymer nano-particle and slow-release medicine capsule and their preparation method, belongs to the capsular preparing technical field of nanoparticle and medicament slow release.
Background technology
In the prior art, although polymer nano-particle at medicine, chemical industry, electronics, field extensive uses such as coating utilize the Biodegradable polymer to come control drug release also to be in experimental stage at present.Its chief reason is owing to degradation-type polymer price comparison costliness, while sustained release mechanism more complicated, and the difference of drug use purpose in addition also causes the corresponding adjustment of polymer formulators needs.A few days ago, by the exploitation of biotechnology, the price of degradation-type polymer reduces greatly; Shape and size by the control nanoparticle in addition, the mechanism that we can well control degradation discharge.
Summary of the invention
The purpose of this patent is to overcome the deficiency of above-mentioned existence, and provide a kind of can be according to present existing condition, pass through process optimization, utilize existing physical method, as have children outside the state plan homogeneous ball-type shaped polymer nanoparticle and medicament capsule and the preparation that emulsification method etc. obtains, and this nanoparticle solids content reaches 10%, and size is less than 300 nanometers, this nanoparticle can be used for sealing soluble small molecular medicine, the release of achieve effective control medicine simultaneously.
This patent is achieved through the following technical solutions:
A kind of polymer nano-particle, it is made of degradation-type macromolecule and surface stabilizer, and wherein the degradation-type macromolecule is a polylactic acid, and surface stabilizer is the mixture of polyvinyl alcohol and chitosan; The weight percent proportioning of polylactic acid is 85--95%, and the weight percent proportioning of the mixture of polyvinyl alcohol and chitosan is 5-15%.
Described polylactic acid weight percent proportioning is 90%, and the weight percent proportioning of the mixture of polyvinyl alcohol and chitosan is 10%.
In the mixture of described polyvinyl alcohol and chitosan, the weight percent proportioning of polyvinyl alcohol is 50-90%, and the weight percent proportioning of chitosan is 10-50%.
The slow-release medicine capsule that a kind of aforesaid polymer nano-particle contains, it is characterized in that: it is sealed in the soluble small molecular medicine in the described nanoparticle that is made of the mixture of polylactic acid and polyvinyl alcohol and chitosan, and the solids content of small-molecule drug in nanoparticle is 1～10%.
The size of described nanoparticle is between 300 nanometers and 3 microns, and big or small homogeneous.
A kind of preparation of aforesaid polymer nano-particle, it is that polylactic acid solution is joined in the water of the mixture that contains polyvinyl alcohol and chitosan, forms water in oil structure, obtains milky solution through stirring after one hour, by crossing the method for ultrasonic emulsification, the nanoparticle that obtains.
Described polylactic acid solution is dissolved in the dichloromethane by polylactic acid and constitutes, and will be added by the mixture that polyvinyl alcohol and chitosan are formed to form the water that contains surface stabilizer in the entry.
A kind of preparation of aforesaid medicament capsule, it mixes polylactic acid and small-molecule drug by prescription, form water in oil structure, obtains milky solution through stirring after one hour, by the method for ultrasonic emulsification, obtains nanoparticle again; This nanoparticle is poured into rapidly in the water that contains by polyvinyl alcohol and chitosan composition mixture, again by the method for ultrasonic emulsification, obtains Biodegradable polymer nano-particle or capsule,
After the present invention will contain the aqueous solution of Gleevec and be dissolved in the polylactic acid solution mix homogeneously of dichloromethane, ultrasonic 2 to 10 minutes of the method for usefulness ultrasonic emulsification obtained being dispersed in the white nanoparticle in the organic solvent; They are poured in the water that contains polyvinyl alcohol and chitosan, and ultrasonic 2 to 10 minutes of the method for lasting stirring usefulness ultrasonic emulsification after 1 hour obtains white water soluble nanometer particles.
Described water soluble nanometer particles surface is owing to present positive charge; And nanoparticle solids content 10%, medicine sealing content is up to 90%.
The present invention utilizes biphase emulsifying and supersound method to prepare the Biodegradable polymer nano-particle at ambient temperature, and adopting macromolecule is that polyelectrolyte molecules is a stabilizing agent; This ball-type nanoparticle (the nanoparticle solids content reaches 10%) that utilizes physical method to obtain, size is less than 300 nanometers, and homogeneous; Nanoparticle can be used for sealing the soluble small molecular medicine in addition, and effective control drug release.
The present invention compared with prior art, it is simple to have preparation technology, has reduced preparation cost, the mechanism that discharges of control degradation has been widened characteristics such as application widely well.
The specific embodiment
Below in conjunction with embodiment this utility model is described in detail:
Embodiment 1: getting the high molecular weight percent proportioning of degradation-type is 85--95%, and the weight percent proportioning of surface stabilizer is 5-15%; Wherein the degradation-type macromolecule be polylactic acid with and derivant or chitosan with and its derivant; Surface stabilizer is by nonionic molecules surfactant and other polyelectrolyte mixture; By polylactic acid with and derivant be dissolved in and make degradation-type macromole solution in the dichloromethane, will mix the surface stabilizer of forming by weight percent proportioning 50-90% polyvinyl alcohol and weight percent proportioning 10-50% chitosan and add and form the water that contains surface stabilizer in the entry.Degradation-type macromole solution is joined in the water that contains surface stabilizer, form water in oil structure, obtaining milky solution through stirring after one hour,, obtaining size between 300 nanometers and 3 microns and uniform degradation-type polymer nano-particle by crossing the method for ultrasonic emulsification.
Embodiment 2: getting the high molecular weight percent proportioning of degradation-type is 85%, and the weight percent proportioning of surface stabilizer is 15%; Wherein the degradation-type macromolecule be polylactic acid with and derivant or chitosan with and its derivant; Surface stabilizer is by nonionic molecules surfactant and other polyelectrolyte mixture; By polylactic acid with and derivant be dissolved in and make degradation-type macromole solution in the dichloromethane, will mix the surface stabilizer of forming by weight percent proportioning 50% polyvinyl alcohol and weight percent proportioning 50% chitosan and add and form the water that contains surface stabilizer in the entry.Degradation-type macromole solution is joined in the water that contains surface stabilizer, form water in oil structure, obtaining milky solution through stirring after one hour,, obtaining size between 300 nanometers and 3 microns and uniform degradation-type polymer nano-particle by crossing the method for ultrasonic emulsification.
Embodiment 3: getting the high molecular weight percent proportioning of degradation-type is 95%, and the weight percent proportioning of surface stabilizer is 5%; Wherein the degradation-type macromolecule be polylactic acid with and derivant or chitosan with and its derivant; Surface stabilizer is by nonionic molecules surfactant and other polyelectrolyte mixture; By polylactic acid with and derivant be dissolved in and make degradation-type macromole solution in the dichloromethane, will mix the surface stabilizer of forming by weight percent proportioning 90% polyvinyl alcohol and weight percent proportioning 10% chitosan and add and form the water that contains surface stabilizer in the entry.Degradation-type macromole solution is joined in the water that contains surface stabilizer, form water in oil structure, obtaining milky solution through stirring after one hour,, obtaining size between 300 nanometers and 3 microns and uniform degradation-type polymer nano-particle by crossing the method for ultrasonic emulsification.
Embodiment 4: the weight percent proportioning that to get the high molecular weight percent proportioning of degradation-type be 85--95%, surface stabilizer is that 5-15% is as the capsular container of slow-release medicine; Get with the proportioning of above-mentioned container at 1～10% small-molecule drug, as the Gleevec medicine, the soluble small molecular medicine is sealed in the described nanoparticle container that is made of degradation-type macromolecule and surface stabilizer macromole.Degradation-type macromole and small-molecule drug are mixed by prescription, form water in oil structure, obtain milky solution after one hour, by the method for ultrasonic emulsification, obtain nanoparticle again through stirring; This nanoparticle is poured into rapidly in the water that contains surface stabilizer, this surface stabilizer is mixed by weight percent proportioning 50-90% polyvinyl alcohol and weight percent proportioning 10-50% chitosan and forms, by the method for ultrasonic emulsification, obtain Biodegradable polymer nano-particle capsule again
Embodiment 5 gets that the high molecular weight percent proportioning of degradation-type is 85%, the weight percent proportioning of surface stabilizer is 15% as the capsular container of slow-release medicine; Get with the proportioning of above-mentioned container at 1% small-molecule drug, as the Gleevec medicine, the soluble small molecular medicine is sealed in the described nanoparticle container that is made of degradation-type macromolecule and surface stabilizer macromole.Degradation-type macromole and small-molecule drug are mixed by prescription, form water in oil structure, obtain milky solution after one hour, by the method for ultrasonic emulsification, obtain nanoparticle again through stirring; This nanoparticle is poured into rapidly in the water that contains surface stabilizer, this surface stabilizer is mixed by percentage by weight 50% polyvinyl alcohol and percentage by weight 50% chitosan and forms, by the method for ultrasonic emulsification, obtain Biodegradable polymer nano-particle capsule again
Embodiment 6 gets that the high molecular weight percent proportioning of degradation-type is 95%, the weight percent proportioning of surface stabilizer is 5% as the capsular container of slow-release medicine; Get with the proportioning of above-mentioned container at 10% small-molecule drug, as the Gleevec medicine, the soluble small molecular medicine is sealed in the described nanoparticle container that is made of degradation-type macromolecule and surface stabilizer macromole, degradation-type macromole and small-molecule drug are mixed by prescription, form water in oil structure, obtain milky solution through stirring after one hour, by the method for ultrasonic emulsification, obtain nanoparticle again; This nanoparticle is poured into rapidly in the water that contains surface stabilizer, this surface stabilizer is mixed by weight percent proportioning 90% polyvinyl alcohol and weight percent proportioning 10% chitosan and forms, by the method for ultrasonic emulsification, obtain Biodegradable polymer nano-particle capsule again.
The present invention is that ultrasonic 2 to 10 minutes of the method for usefulness ultrasonic emulsification obtains being dispersed in the white nanoparticle in the organic solvent with after containing the aqueous solution of Gleevec small-molecule drug and being dissolved in the polylactic acid solution mix homogeneously of dichloromethane; They are poured in the water that contains polyvinyl alcohol and chitosan, and ultrasonic 2 to 10 minutes of the method for lasting stirring usefulness ultrasonic emulsification after 1 hour obtains white water soluble nanometer particles.
Water soluble nanometer particles of the present invention surface is owing to present positive charge; And nanoparticle solids content 10%, medicine sealing content is up to 90%.
The solids content of small-molecule drug of the present invention in nanoparticle is 1～10%.
Described nano-particles size size is between 300 nanometers and 3 microns, and big or small homogeneous.
Embodiment 7: 500 milligrams of polylactic acid of dissolving are in 10 milliliters of dichloromethane, with this solution with contain in water 30 grams of 300 milligrams of 300 milligrams of polyvinyl alcohol and chitosans, stir after 1 hour with ultrasonic 2 to 10 minutes of the method for ultrasonic emulsification, will obtain the water soluble nanometer particles of white.This nanoparticle surface is owing to there is the existence of chitosan to present positive charge.This method prepares nanoparticle solids content 10%
Embodiment 8: will contain 500 milligrams of the solution of water 2 gram of Gleevec 30mg and dissolving polylactic acid behind 10 milliliters of mix homogeneously of dichloromethane, with ultrasonic 2 to 10 minutes of the method for ultrasonic emulsification, the nanoparticle that will obtain white was dispersed in the organic solvent.This solution is poured in water 30 grams that contain 300 milligrams of 300 milligrams of polyvinyl alcohol and chitosans, continued to stir after 1 hour, will obtain the water soluble nanometer particles of white with ultrasonic 2 to 10 minutes of the method for ultrasonic emulsification.This nanoparticle surface is owing to there is the existence of chitosan to present positive charge.This method prepares nanoparticle solids content 10%, and medicine sealing content is up to 90%.
Claims (10)
1, a kind of polymer nano-particle is characterized in that: it is made of degradation-type macromolecule and surface stabilizer, and wherein the degradation-type macromolecule is a polylactic acid, and surface stabilizer is the mixture of polyvinyl alcohol and chitosan; The weight percent proportioning of polylactic acid is 85-95%, and the weight percent proportioning of the mixture of polyvinyl alcohol and chitosan is 5-15%.
2, polymer nano-particle according to claim 1 is characterized in that described polylactic acid weight percent proportioning is 90%, and the weight percent proportioning of the mixture of polyvinyl alcohol and chitosan is 10%.
3, polymer nano-particle according to claim 2 is characterized in that in the mixture of described polyvinyl alcohol and chitosan that the weight percent proportioning of polyvinyl alcohol is 50-90%, and the weight percent proportioning of chitosan is 10-50%.
4, a kind of by slow-release medicine capsule as claim 1 or 2 or 3 described polymer nano-particles containings, it is characterized in that: it is sealed in the soluble small molecular medicine in the described nanoparticle that is made of the mixture of polylactic acid and polyvinyl alcohol and chitosan, and the solids content of small-molecule drug in nanoparticle is 1～10%.
5, medicament capsule according to claim 4, the size that it is characterized in that nanoparticle is between 300 nanometers and 3 microns, and big or small homogeneous.
6, a kind of preparation as claim 1 or 2 or 3 described polymer nano-particles, it is that polylactic acid solution is joined in the water of the mixture that contains polyvinyl alcohol and chitosan, form water in oil structure, obtain milky solution through stirring after one hour, by crossing the method for ultrasonic emulsification, the nanoparticle that obtains.
7, the preparation of polymer nano-particle according to claim 6, it is characterized in that described polylactic acid solution is dissolved in the dichloromethane by polylactic acid constitutes, and will be added by the mixture that polyvinyl alcohol and chitosan are formed to form the water that contains surface stabilizer in the entry.
8, a kind of preparation as claim 4 or 5 described medicament capsules, it is characterized in that: it mixes polylactic acid and small-molecule drug by prescription, form water in oil structure, obtains milky solution through stirring after one hour, by the method for ultrasonic emulsification, obtain nanoparticle again; This nanoparticle is poured into rapidly in the water that contains by polyvinyl alcohol and chitosan composition mixture, again by the method for ultrasonic emulsification, obtains Biodegradable polymer nano-particle or capsule.
9, the preparation of medicament capsule according to claim 8, after it is characterized in that to contain the aqueous solution of Gleevec and being dissolved in the polylactic acid solution mix homogeneously of dichloromethane, with the method for ultrasonic emulsification ultrasonic 2 to 10 minutes, obtain being dispersed in the white nanoparticle in the organic solvent; They are poured in the water that contains polyvinyl alcohol and chitosan, and ultrasonic 2 to 10 minutes of the method for lasting stirring usefulness ultrasonic emulsification after 1 hour obtains white water soluble nanometer particles.
10, the preparation of medicament capsule according to claim 9 is characterized in that the water soluble nanometer particles surface owing to present positive charge; And nanoparticle solids content 10%, medicine sealing content is up to 90%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100605749A CN1309422C (en) | 2005-08-29 | 2005-08-29 | Nanometer particle and medicine capsule of polymeric compound and preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100605749A CN1309422C (en) | 2005-08-29 | 2005-08-29 | Nanometer particle and medicine capsule of polymeric compound and preparation |
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| Publication Number | Publication Date |
|---|---|
| CN1733310A CN1733310A (en) | 2006-02-15 |
| CN1309422C true CN1309422C (en) | 2007-04-11 |
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| CNB2005100605749A Expired - Fee Related CN1309422C (en) | 2005-08-29 | 2005-08-29 | Nanometer particle and medicine capsule of polymeric compound and preparation |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0602338A (en) * | 2006-03-24 | 2007-12-11 | Univ Kyushu Nat Univ Corp | organic compounds |
| CN103417515B (en) * | 2013-08-07 | 2015-03-04 | 中山大学 | Biodegradable nanoparticle-entrapped oral colon-targeted micro-capsule and preparation method thereof |
| CN105310986A (en) * | 2015-10-09 | 2016-02-10 | 北京万全德众医药生物技术有限公司 | Olodaterol lung targeting nanoparticle and its preparation method |
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Non-Patent Citations (3)
| Title |
|---|
| 四川科学技术出版社 罗明生等，药剂辅料大全，第1期 1995 * |
| 聚乳酸微球表面的氨等离子体表面改性 常江等，化学工业与工程，第21期 2004 * |
| 聚乳酸微球表面的氨等离子体表面改性 常江等，化学工业与工程，第21期 2004;四川科学技术出版社 罗明生等，药剂辅料大全，第1期 1995 * |
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