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CN1373770A - 假单胞菌素前药 - Google Patents

假单胞菌素前药 Download PDF

Info

Publication number
CN1373770A
CN1373770A CN00810331A CN00810331A CN1373770A CN 1373770 A CN1373770 A CN 1373770A CN 00810331 A CN00810331 A CN 00810331A CN 00810331 A CN00810331 A CN 00810331A CN 1373770 A CN1373770 A CN 1373770A
Authority
CN
China
Prior art keywords
alkyl
pseudomycin
alkoxyl group
prodrug
perhaps
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00810331A
Other languages
English (en)
Chinese (zh)
Inventor
S·H·陈
M·J·罗德里格茨
X孙.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CN1373770A publication Critical patent/CN1373770A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN00810331A 1999-07-15 2000-06-08 假单胞菌素前药 Pending CN1373770A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14384099P 1999-07-15 1999-07-15
US60/143,840 1999-07-15

Publications (1)

Publication Number Publication Date
CN1373770A true CN1373770A (zh) 2002-10-09

Family

ID=22505903

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00810331A Pending CN1373770A (zh) 1999-07-15 2000-06-08 假单胞菌素前药

Country Status (11)

Country Link
EP (1) EP1198470A1 (fr)
JP (1) JP2003505396A (fr)
CN (1) CN1373770A (fr)
AU (1) AU5310500A (fr)
BR (1) BR0013153A (fr)
CA (1) CA2379058A1 (fr)
EA (1) EA200200161A1 (fr)
HU (1) HUP0202223A3 (fr)
MX (1) MXPA02000315A (fr)
NO (1) NO20020192L (fr)
WO (1) WO2001005813A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1902175B (zh) * 2003-12-30 2012-08-22 什诺波特有限公司 酰氧基烃基氨基甲酸酯前药及其中间体的合成

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
KR20110097942A (ko) * 2003-08-20 2011-08-31 제노포트 인코포레이티드 아실옥시알킬 카르바메이트 프로드러그, 합성 및 사용 방법
WO2005066122A2 (fr) 2003-12-30 2005-07-21 Xenoport, Inc. Synthese de promedicaments a base de carbamate d'acyloxyalkyle et leurs intermediaires
JP4938771B2 (ja) 2005-06-20 2012-05-23 ゼノポート，インコーポレーテッド トラネキサム酸のカルバミン酸アシルオキシアルキルプロドラッグ、合成法、および使用
TW200820963A (en) 2006-07-28 2008-05-16 Xenoport Inc Acyloxyalkyl carbamate prodrugs of α-amino acids, methods of synthesis and use
WO2010017498A1 (fr) * 2008-08-07 2010-02-11 Xenoport, Inc. Procédés de synthèse de carbonates de n-hydroxysuccinimidyle

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5576298A (en) * 1992-11-30 1996-11-19 Research And Development Institute, Inc. At Montana State University Peptides from pseudomonas syringae possessing broad-spectrum antibiotic activity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1902175B (zh) * 2003-12-30 2012-08-22 什诺波特有限公司 酰氧基烃基氨基甲酸酯前药及其中间体的合成

Also Published As

Publication number Publication date
CA2379058A1 (fr) 2001-01-25
WO2001005813A1 (fr) 2001-01-25
EP1198470A1 (fr) 2002-04-24
JP2003505396A (ja) 2003-02-12
HUP0202223A3 (en) 2002-11-28
MXPA02000315A (es) 2002-06-21
NO20020192D0 (no) 2002-01-14
BR0013153A (pt) 2002-04-02
EA200200161A1 (ru) 2002-06-27
NO20020192L (no) 2002-03-14
AU5310500A (en) 2001-02-05
HUP0202223A2 (en) 2002-10-28

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Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication