CN1367658A - Method for treating and preventing finger disorders - Google Patents
Method for treating and preventing finger disorders Download PDFInfo
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- CN1367658A CN1367658A CN00811032A CN00811032A CN1367658A CN 1367658 A CN1367658 A CN 1367658A CN 00811032 A CN00811032 A CN 00811032A CN 00811032 A CN00811032 A CN 00811032A CN 1367658 A CN1367658 A CN 1367658A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D29/00—Manicuring or pedicuring implements
- A45D29/16—Cuticle sticks
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- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D34/00—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes
- A45D34/04—Appliances specially adapted for applying liquid, e.g. using roller or ball
- A45D34/042—Appliances specially adapted for applying liquid, e.g. using roller or ball using a brush or the like
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
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Abstract
本发明涉及了一种预防或处理手指毛病的方法。确切地说,本发明涉及了发放和涂敷指甲和表皮处理合成物的改进方法。
The present invention relates to a method for preventing or treating finger ailments. More particularly, the present invention relates to an improved method for dispensing and applying nail and cuticle treatment compositions.
Description
发明领域Field of Invention
本发明涉及了一种预防或处理手指毛病的方法。确切地说,本发明涉及了发放和涂敷指甲和表皮处理合成物的改进方法。The invention relates to a method for preventing or treating finger troubles. More specifically, the present invention relates to improved methods of dispensing and applying nail and cuticle treatment compositions.
发明背景Background of the Invention
目前市场上存在多种多样的手指或指甲处理方法。这种指甲处理方法的范围包括从纯粹修饰到几乎完全药疗方法。理想上,这种手指或指甲处理方法应该同时是修饰性和药疗性的。但是,这种双重目的往往难以在单一的涂敷处理中达到。例如,修饰性的指甲处理通常需要非药疗的成分,如成膜聚合物或色素,它们不用于涂敷表皮或邻近皮肤,并且往往对这些手指区域有不利的影响(如促进了干燥性)。A wide variety of finger or nail treatments currently exist on the market. Such nail treatments range from purely grooming to almost exclusively medicinal. Ideally, this finger or nail treatment should be cosmetic and medicinal at the same time. However, this dual purpose is often difficult to achieve in a single coating process. For example, grooming nail treatments often require non-pharmaceutical ingredients, such as film-forming polymers or pigments, that are not intended to coat the epidermis or adjacent skin and often have adverse effects on these finger areas (eg, promote dryness) .
药疗性的指甲处理有助于使指甲表面光滑和软化。确切地说,这种处理滋养和软化了表皮和周围皮肤组织,同时降低了指甲本身的脆性。这对具有干燥和脆性指甲的人来说特别重要。Medicinal nail treatments help smooth and soften the nail surface. Specifically, this treatment nourishes and softens the cuticle and surrounding skin tissue while reducing the brittleness of the nail itself. This is especially important for people with dry and brittle nails.
另外,手指或指甲处理的涂敷应该同时是方便和可控的。使用者应该对为了有效和美观目的所涂敷的处理量保持控制(即光滑和均匀的涂敷)。这种使用方便和控制性质也避免了处理合成物脏乱的过分涂敷和有助于改进使用者对使用这种处理方法的适应性。本发明人发现,本发明的方法改进了手指或指甲处理合成物的发放,从而改进了方便性、美观性以及使用者与对这种处理的适应性。Additionally, the application of the finger or nail treatment should be both convenient and controllable. The user should maintain control over the amount of treatment applied for efficacy and aesthetics (ie smooth and even application). This ease of use and control also avoids messy over-application of the treatment composition and helps improve the user's comfort with using the treatment method. The present inventors have discovered that the method of the present invention improves the dispensing of finger or nail treatment compositions, thereby improving convenience, aesthetics, and user compliance with such treatments.
因此,本发明的一个方面是提供了处理或预防手指毛病、特别是指甲和表皮毛病的新的和改进的方法。Accordingly, it is an aspect of the present invention to provide new and improved methods of treating or preventing finger disorders, particularly nail and cuticle disorders.
另一个方面是提供了湿润、光滑和软化指甲表面和指甲周围皮肤和组织表面的方法。Another aspect is to provide a method of moistening, smoothing and softening the surface of the nail and the surface of the skin and tissue surrounding the nail.
本发明的又一个方面是提供了湿润、光滑和软化指甲表面和指甲周围皮肤和组织表面的方法,包括采用一个改进的涂敷装置来涂敷手指或指甲处理合成物。In yet another aspect of the present invention there is provided a method of wetting, smoothing and softening the surface of the nail and the surface of the skin and tissue surrounding the nail comprising applying a finger or nail treatment composition using an improved applicator.
发明概述Invention Summary
本发明涉及了处理或预防手指毛病的方法,包括如下步骤:The present invention relates to the method for processing or preventing finger trouble, comprises the following steps:
A)提供一个发放手指处理合成物的发放装置,包括:A) Provide a dispensing device for dispensing a finger treatment composition comprising:
i)一个确定了一个腔室的外壳,它具有一个发放端和一个作动端,上述发放端具有一个涂敷区和上述腔室具有一个内表面,上述涂敷区提供了手指处理合成物的光滑和均匀的表面分布;i) a housing defining a chamber having a dispensing end and an actuating end, said dispensing end having an application zone and said chamber having an interior surface, said application zone providing a release of the finger treatment composition smooth and even surface distribution;
ii)一个位于上述腔室内的活塞,上述活塞能够在上述腔室内移动,上述活塞具有一个面对上述外壳的上述发放端的顶侧,并且具有一个背对着上述顶侧的前进机构,上述活塞的上述顶侧在上述腔室和上述活塞的上述顶侧之间形成了上述腔室的一个可变容积区,其中上述可变容积区用于贮存上述指甲和表皮处理合成物;以及ii) a piston located in said chamber, said piston being movable within said chamber, said piston having a top side facing said dispensing end of said housing, and having an advancing mechanism facing away from said top side, said piston's said top side defines a variable volume region of said chamber between said chamber and said top side of said piston, wherein said variable volume region is used to store said nail and cuticle treatment composition; and
iii)一个调节器,可动地装在上述外壳上,并且可动地在上述外壳的上述作动端与上述内表面配合,上述调节器配合上述前进机构,用于使上述活塞朝着上述发放端方向前进;iii) An adjuster, movably installed on the above-mentioned casing, and movably cooperates with the above-mentioned inner surface at the above-mentioned actuating end of the above-mentioned casing, and the above-mentioned adjuster cooperates with the above-mentioned advancing mechanism, and is used to make the above-mentioned piston move toward the above-mentioned end direction forward;
其中装置预先填充了手指处理合成物,手指处理合成物包括从约1.0%到约99%的油性成分,以及其中合成物包含小于1.0%的成膜聚合物;以及wherein the device is pre-filled with a finger treatment composition, the finger treatment composition comprising from about 1.0% to about 99% oily ingredients, and wherein the composition comprises less than 1.0% film-forming polymer; and
B)从发放装置把手指处理合成物发放到手指或指甲上。B) Dispensing the finger treatment composition from the dispensing device onto the fingers or nails.
附图简述Brief description of the attached drawings
尽管本技术说明以权利要求来结束,指出了和明确地申请了本发明的专利范围,但相信从结合附图的以下详细描述,将会更好地理解本发明,图中相同的编号表示完全相同的零部件,其中:Although the technical description ends with the claims, pointing out and clearly applying for the patent scope of the present invention, it is believed that from the following detailed description in conjunction with the accompanying drawings, the present invention will be better understood, and the same numbering in the figure indicates complete Identical components, where:
图1是本发明发放装置一个优选实施例的透视图;Fig. 1 is the perspective view of a preferred embodiment of dispensing device of the present invention;
图2是不带帽的图1所示发放装置的垂直剖视图;以及Figure 2 is a vertical cross-sectional view of the dispensing device shown in Figure 1 without the cap; and
图3是安装了帽的图1所示发放装置的垂直剖视图,具有另一个制品提升器实施例。Figure 3 is a vertical cross-sectional view of the dispensing device of Figure 1 with the cap installed, with another embodiment of the product lifter.
本发明详述A.发放装置A. Dispensing device
参照附图,以10概括地表示一个手指处理发放装置,用于发放手指处理合成物,如流体、乳油、半固体、凝胶、软膏、液体等。发放装置10部分地包括一个概括地用51表示的调节器,它可以是一个可转动的手轮,可动地连接到一个外壳20上,外壳20与一个概括地用80表示的涂敷器连接。调节器可以是适于使活塞前进的任何机构。例如,按钮或推压式棘轮前进机构是适当的替代品。还供选用地提供了一个具有闭端17和开端18的帽14。例如依靠与涂敷器80的摩擦配合,把帽14可卸除地与发放装置10连接。Referring to the drawings, generally indicated at 10 is a finger treatment dispensing device for dispensing finger treatment compositions such as fluids, creams, semisolids, gels, ointments, liquids, and the like. The
参照图2,其中可看到发放装置10的一个垂直剖视图,外壳20空心而细长,并且具有一条沿其长度延伸的轴线。外壳20中具有一个腔室21,并且包括一个对着作动端26的敞开的发放端24,作动端26具有一个内表面28。最好是,内表面28为圆柱形。用于这里的圆柱形是指一个细长而具有大致圆截面的三维形状。最好是,内表面28从外壳20的作动端26延伸到发放端24。腔室21的截面形状可以替代地为各种形状,如椭圆形、矩形、扁长形、不规则形等。在作动端26,内表面28包括一个唇边30和至少一个制动区32。制动区32包括一个在内表面28中的基本为局部的凹槽、凹区或凸起。内表面28可以包括许多制动区32,这些制动区32最好沿内表面28径向隔开。唇边30最好位于径向隔开的制动区32附近和之后。发放端24可以包括一个缩小或减少截面的第一缩径区23,在发放时制品通过缩径区。最好是,第一缩径区23为截锥形。另外,外壳20的发放端24具有一个包括一条棱36的外表面34。外表面34最好为圆柱形。外壳20优先由如尼龙、丙烯腈-丁二烯-苯乙烯(ABS)、聚丙烯(PP)、聚乙烯(PE)、苯乙烯-丙烯腈(SAN)等材料构成,或者更好地由如带ABS的聚对苯二甲酸丁二醇酯(PBT)的材料构成,或者最好地,可以采用购自BP化学公司牌号为BAREX.TM.210的橡胶改性丙烯腈共聚物。Referring to Figure 2, in which a vertical cross-sectional view of dispensing
一个活塞40位于外壳20的腔室21内。这个活塞40最好限于在腔室21内轴向或移动运动,并且最好不相对于内表面28转动。活塞40具有一个面对外壳20发放端24的顶侧42和一个背对着顶侧42的底侧44。当活塞40沿轴向在腔室21内移动时,活塞40的顶侧42在腔室21内形成一个可变容积区22。这个可变容积区22用于贮存要从发放装置10发放的制品。在一个优选实施例中,活塞40的顶侧42上设有一个与内表面28密封配合的上密封边43。活塞40的底侧44也可以设有一个与内表面28密封配合的下密封边45。上密封边43和下密封边45分别从活塞40的顶侧42和底侧44沿径向朝外延伸。最好是,上密封边43和下密封边45预防贮存在可变容积区22中的制品通过活塞40朝着外壳20的作动端26或腔室21的任何其他部分泄漏。上密封边43和下密封边45与内表面28之间的密封配合和摩擦力阻止了活塞40的转动。因此,活塞40一般被限于移动运动。改变上密封边43或下密封边45与内表面28之间的表面接触量,可以增加或减少这些摩擦力。A
如图所示,外壳20最好为具有大致圆截面的圆柱形。或者是,外壳20可以具有大致椭圆截面或甚至不规则的截面。如果外壳20内的腔室21为非圆截面,则腔室21的轮廓或截面形状进一步预防了活塞40的转动,因为活塞40最好具有与腔室21相同的轮廓。活塞40最好由氟化的高密度聚乙烯(HDPE)构成,虽然也可以采用许多其他柔性聚合物。As shown,
如图所示,活塞40还具有一个背对着顶侧42从活塞伸出的螺杆46。因此,螺杆46从活塞40的底侧44伸向外壳20的作动端26。最好是螺杆46由缩醛制成。螺杆46的上端47固定连接到活塞40的底侧44。因此螺杆46和活塞40成一体运动,该运动限于轴向移动。活塞40与螺杆46连接的组合体形成了一个制品提升器48,其作用是移动制品推出到外壳20中腔室21的可变容积区22之外。如图3所示,制品提升器48可以是一个单件,包括了与活塞40整体形成的螺杆46。在图2所示的优选实施例中,活塞40和螺杆46可以是分开的构件。为了限制制品提升器48的轴向行程,在背对着螺杆46上端47的另一端,可以在螺杆46上设有一个螺杆挡块49。也可以使制品提升器48或活塞40在腔室21的可变容积区22中简单地碰到底来限制制品提升器48的行程量。可以采用限制轴向行程的其他替代方法,例如,螺杆46可以部分地带螺纹,螺杆46或活塞40可以做得较短或较长,活塞40可以在顶侧42设有一个凸起,以及在限制相似构件轴向行程技术中已知的各种其他方法。As shown, the
如图2所示,当调节器为手轮时,具有一个螺孔52的作动器50设在手轮51上。最好是,螺孔52与作动器50同心。作动器50在外壳20的作动端26上与内表面28配合,并且适于仅沿一个方向,即沿前进的方向相对于外壳20转动。由于螺杆46上的螺纹与螺孔52配合,螺杆46与螺孔52的配合使得当作动器50转动时,活塞40朝外壳20的发放端24前进,由此使制品从发放装置10发放。As shown in FIG. 2 , when the regulator is a handwheel, an
在使用时,手轮51最好是一个同时包括作动器50和握住区54的整体单件。因此,手轮51包括了具有螺孔52的作动器50,并且具有与作动器50连接的握住区54。握住区54从外壳20的作动端26伸出,最好具有一个带槽或滚花的表面,以便使用者易于握住手轮51。最好是,一个空腔59沿轴向延伸通过手轮51的握住区54,以提供通向螺孔52的入口。更好地,螺孔52小于螺杆的挡块49,而空腔59容许螺杆挡块49通过。作动器50包括一条槽56,它在外壳20的作动端26上与内表面28上的唇边30配合或被捕获,使得作动器50可以转动但不能相对于内表面28作轴向运动。这种构造容许手轮51转动而阻止手轮51的轴向运动。手轮51最好采用喷射模制方法由塑料形成单件,如购自DOW化学公司牌号为MAGNUM.TM.9015的ABS,也可以采用具有碳化钙填料的PP均聚物或共聚物,填料的填充程度从重量的约5%到约40%。In use, the
手轮51上的作动器50最好还包括至少一个弹性臂58,从作动器50沿径向朝外伸出,并且可以朝内表面28沿径向倾斜。在这里的弹性是指弹性臂58的性质,它依靠从其原始位置的挠曲迫使它回到其原始位置。弹性臂58可以参照图4更好地看出,图中表示了沿图2的4-4线所取的发放装置10的整个截面。弹性臂58与内表面28上的制动区32配合,使得作动器50可以沿前进方向转动但不能沿相反方向转动。作动器50最好具有至少两个弹性臂58。更好地,弹性臂58朝内表面28向外与径向成一个角度,使得当手轮51沿前进方向转动时,弹性臂58与制动区32配合并被制动区32向内挠曲。当手轮51沿前进方向转动时,螺杆46与螺孔52的配合使活塞40朝发放端24移动。任何沿相反方向的手轮51转动企图均被限制,并且使弹性臂58靠在制动区32上,预防了手轮51沿相反方向的转动。由于手轮51限制成仅沿前进方向转动,仅容许制品提升器48沿一个方向移动。因此,发放装置10具有单向性质。The
为了从发放装置10以可控方式发放制品,使用者转动手轮51。最好是,绕着内表面28沿径向隔开制动区32,当手轮51沿前进方向转动时弹性臂58与制动区32配合和脱开。弹性臂58与制动区32的每次配合提供了活塞40移动的某些增量,因此提供了制品提升器48移动的增量。可以改变制动区32之间的径向间隔来提供每次转动增量的活塞40轴向移动的多或少。例如,制动区32可以绕着内表面28均匀地隔开,不规则地隔开,甚至以变化的距离间断地隔开。活塞40运动的增量控制了从可变容积区22发放的制品量,发放了一个增量容积的制品,因此达到了制品剂量的增加。这种剂量的增加有助于使用者发放精确或正规的制品量,并且有助于避免脏乱或浪费的过分发放。To dispense articles from the dispensing
这种构造的一个优点是当手轮51沿前进方向转动时产生可听到的声音。当转动作动器50期间弹性臂58从制动区32弹回并与外壳20内表面28接触时,产生了这种咔嗒声。此外,当手轮51沿前进方向转动时产生一个有触觉的信号。当弹性臂58向内挠曲并且压在每个制动区32之间的内表面28上而产生张力时,产生了对转动间断阻力的感觉。当弹性臂58朝着和进入制动区32向外弹回时,这种张力被释放。例如,转动手轮51一定咔嗒声数目来达到剂量的增加,可以规定咔嗒声数目来提供精确的制品剂量。One advantage of this configuration is that an audible sound is produced when the
一个涂敷器80可以连接在外壳20的发放端24,与腔室21的可变容积区22液体连通,使得通过涂敷器80来发放制品。涂敷器80是空心的,并且包括套圈82和涂敷区84。涂敷器80最好由塑料构成,如PP、PE、聚对苯二甲酸乙二醇酯(PET)、尼龙、或者甚至如购自DuPont公司牌号为HYTREL.TM.5526的聚酯。套圈82位于涂敷区84的另一端并且与外壳20的发放端24连接。套圈82包括一个具有凸缘边89的内表面85。凸缘边89与发放端24上的棱36配合,形成了套圈82和发放端24之间的咬合配合79,由此把涂敷器80连接在外壳20上。涂敷器80的涂敷区84具有至少一个孔86,以便通过涂敷器80来发放制品。最好是,孔86可以具有从约0.25mm(0.01英寸)到约5mm(0.2英寸)的直径。An
再参照图2,表示了一个优选实施例,其中涂敷区84具有一个孔86,纤维刚毛72通过孔86伸出。这种类型的纤维刚毛72可以成圆锥形,最好纤维刚毛72具有从约0.1mm(0.004英寸)到约0.05mm(0.002英寸)的粗细或直径。这些纤维刚毛72可以由各种材料制成,但最好由如尼龙的塑料制成,更好地由聚对苯二甲酸丁二醇酯(PBT)制成。改变纤维刚毛72的长度或相邻部分的粗细,可以容易地改变纤维刚毛72伸出涂敷区84之外的量。在图2所示的这个优选实施例中,在涂敷器80中形成一个内肩部88和一个平台锁扣95。最好是平台锁扣95朝着孔86沿轴向隔开,同时也以台阶方式从内肩部88向内沿径向隔开。平台锁扣95的形式为等间隔分开的四个向内突出撑条。或者是,平台锁扣95可以是任何沿径向向内的突起。一个具有径向伸出边96的过渡件90位于外壳20的发放端24内,使得边96被捕获在内肩部88和外壳20的发放端24之间。最好是边96把过渡件90分隔成一个上过渡区97和一个下过渡区93。过渡件90可以由氟化HDPE或某些其他柔性聚合物构成。过渡件90具有一个通道92,它使孔86和纤维刚毛72与腔室21的可变容积区22液体连通。相似于第一缩径区23,一个第二缩径区25可以位于通道92内,以缩小或减少在发放时制品通过的截面,由此起到减小通过通道92的流动面积的作用。最好是,过渡件90的位置使得它通过套圈82伸入涂敷器80的涂敷区84中。或者是,具有通道92的过渡件90可以通过涂敷器80伸出并且在涂敷区84之外。在这个优选实施例中,一个具有中心开孔的环形平台94固定到形成刷尖74的纤维刚毛72上。过渡件90的上过渡区97延伸通过环形平台94中的开孔。环形平台94被捕获在过渡件90的边96和平台锁扣95之间,使得相对于涂敷区84中的开孔86,环形平台94确定了刷尖74的纤维刚毛72位置。Referring again to FIG. 2, a preferred embodiment is shown in which the
再参照图3,表示了安装在发放装置10的涂敷器80上的一个选用的帽14,由此密封闭合了涂敷器80的开孔86和涂敷区84。最好是帽14的闭端17与涂敷器80隔开和不接触。如图1所示,帽14可以卸除。一条涂敷器肋16设在涂敷器80上,一条帽锁定肋19设在帽14的内部。帽锁定肋19形式可以是间断或连续的突起。当帽14装到涂敷器80上时,涂敷器肋16和帽锁定肋19配合,把帽14可卸除地固定在涂敷器80上。为了把帽14连接定位在涂敷器80上,开端18(图1)与涂敷器80配合,使得涂敷器肋16与帽锁定肋19配合。因此,当不使用发放装置10时使用者可以简单地把帽14咬合定位在涂敷器80上,并且为了接近涂敷器80也可以容易地卸除帽14。在图3所示的实施例中,帽锁定肋19或涂敷器肋16稍微变形,然后回到其正常位置,以保证帽14保持定位,直到使用者为了发放制品而卸除帽14时为止。帽14的内部还设有一条密封凸缘15,其位置对准涂敷器80上的密封面81。帽14上的密封凸缘15与涂敷器80的密封面81配合,提供了帽14和涂敷器80的密封配合,使得当帽14装在涂敷器80上时,在帽14和涂敷器80之间产生气密。因此,帽14与涂敷器80上的套圈82密封地配合,阻止了在发放装置10的可变容积区22内保存的任何制品逸出或制品干燥。最好是,当帽位于安装位置时,帽14外部与涂敷器80和外壳20之间保持平滑或平齐的轮廓。Referring again to FIG. 3, an
如图2和3所示,易于完成发放装置的装配,可以从把制品提升器48螺接到手轮51上来开始。把螺杆46与螺孔52以某种方式配合,该方式使得在需要时容许活塞40的底侧44与螺杆46的上端47连接。然后把制品提升器48和手轮51插入外壳20的作动端26,使得槽56和唇边30配合,由此可转动地连接定位了手轮51,同时也把活塞40定位在腔室21内,形成了可变容积区22。在装配时应该小心定位弹性臂58来与制动区32适当配合,以避免弹性臂58的受载或打滑。然后可以对可变容积区22填充制品。如果需要,可以把过渡件90放入外壳20的发放端24中,以及如果需要,可以把刷尖74装在过渡件90上。可以在过渡件90之上把涂敷器80连接到发放端24上,安装时捕获了刷尖74。还可以把帽14可卸除地连接在涂敷器80上。As shown in Figures 2 and 3, assembly of the dispensing device is easily accomplished by screwing the
或者是,也可以从颠倒放置外壳20来开始,使得作动端26面朝上,然后通过作动端26把活塞40放入外壳20的腔室21内,使得底侧44面朝上。然后把手轮51插入外壳20的作动端26,可以通过空腔59把螺杆46的上端47与活塞40的底侧44连接,同时配合手轮51的螺孔52。虽然可以利用这里描述的发放装置10发放如流体、流动材料、半固体或液体,但主要是发放不含成膜剂和/或色素的手指处理合成物。当采用这种发放装置10发放和涂敷手指或指甲处理合成物时,得到了一层均匀薄膜。Alternatively, it is also possible to start by placing the
虽然已经表示和描述了本发明的特定形式和实施例,但可以对这种发放装置10作出各种修改而不偏离本发明说明的内容。例如,采用把构件咬合在一起以外的方法,包括螺接、胶接、焊接等,可以形成各构件之间的各种连接。在本发明描述中采用的名称仅用作说明的意义,而不作为限制的名称。可以设想名称的所有相当物包括在所附权利要求范围之内。在美国专利号5,851,079;5,827,002和5,830,640中可以找到其他适当的实施例,为了完整性均引入这里作为参考。一个特别优选的发放装置是Mitsubishi Pencil KabushkiKaisha的UC18C笔。UC18C笔的更详细描述可以在PCT申请号PCT/JP99/01450中找到,为了完整性引入这里作为参考。B.手指处理合成物While particular forms and embodiments of the invention have been shown and described, various modifications may be made to the dispensing
本发明的手指或指甲处理合成物可以包括、包含或基本包括这里描述的本发明的基本成分和限制,以及这里描述的任何附加或选用的配料、成分或限制。The finger or nail treatment compositions of the present invention may comprise, comprise or consist essentially of the essential ingredients and limitations of the invention described herein, as well as any additional or optional ingredients, ingredients or limitations described herein.
除非另作规定,所有百分比、部分和比值均基于本发明专用处理合成物的总重量。除非另作规定,与列出成分有关的所有这些重量均基于有效的含量,因此不包括可能在采购材料中包括的载体或副产物。Unless otherwise specified, all percentages, parts and ratios are based on the total weight of the special treatment compositions of the present invention. All such weights as they pertain to listed ingredients are based on the active level and, therefore, do not include carriers or by-products that may be included in purchased materials, unless otherwise specified.
用于这里的词语“手指或指甲”意味着指甲和指甲周围的手指区,包括表皮和周围皮肤组织。The term "finger or nail" as used herein means the nail and the area of the finger surrounding the nail, including the epidermis and surrounding skin tissue.
用于这里的词语“手指毛病”包括(但不限于)脆性指甲、干燥指甲、剥离指甲、撕裂指甲、开裂皮肤、干燥皮肤、剥离皮肤、灰白皮肤、硬结皮肤和指甲倒刺。The term "finger problems" as used herein includes, but is not limited to, brittle nails, dry nails, peeling nails, torn nails, cracked skin, dry skin, peeling skin, gray skin, incrusted skin, and nail barbs.
用于这里的词语“安全和有效量”意味着足以明显引入确实效果的复合物或合成物的量,最好是引入湿润和软化效果,更好地是直观的干燥程度的减少,独立地包括了这里公布的各种效果,但量低到足以避免严重的副作用,即在熟练技术人员正常判断范围内,提供了一个合理的效果与风险比。The phrase "safe and effective amount" as used herein means an amount of the compound or composition sufficient to appreciably introduce a positive effect, preferably a moisturizing and softening effect, more preferably a visual reduction in dryness, independently comprising The various effects published here are not limited, but the amount is low enough to avoid serious side effects, that is, within the normal judgment range of the skilled artisan, to provide a reasonable effect to risk ratio.
这里采用的词语“处理”或“处理和/或预防”意味着对哺乳动物中指甲或指甲周围皮肤毛病的处理,包括:The words "treating" or "treating and/or preventing" are used herein to mean the treatment of nail or perinail skin disorders in mammals, including:
(i)预防毛病,即使得毛病的症状不发展;(i) prevent the disease, that is, prevent the symptoms of the disease from developing;
(ii)阻止毛病,即抑制症状的发展;(ii) arresting the disorder, that is, inhibiting the development of symptoms;
(iii)减轻毛病,即使得症状消退。(iii) Alleviation of a disease, that is, causing the symptoms to subside.
以下详细描述本发明的手指处理合成物,包括其基本成分和选用成分。The finger treatment compositions of the present invention, including their essential and optional ingredients, are described in detail below.
基本成分油性成分Essential Ingredients Oily Ingredients
本发明的基本成分是油性成分。适当油性成分的例子包括脂肪和油、蜡、碳氢化合物、高级脂肪酸、高级醇、酯、香精油和硅油。脂肪和油的例子包括天然脂肪和油,如豆油、糠油(米糠油)、西蒙得木油、鳄梨油、杏仁油、橄榄油、可可油、红花油、葵花籽油、芝麻油、桃仁油(杏仁油)、蓖麻油、棕榈油、貂油、牛脂和猪脂;由这些天然脂肪和油氢化得到的硬化油;以及合成甘油三脂,如三肉豆蔻精和甘油基三(2-乙基己酸)。蜡的例子包括巴西棕榈蜡、鲸蜡、蜂蜡和羊毛脂。碳氢化合物的例子包括液态石蜡、凡士林、石蜡微晶蜡、地蜡、角鲨烷和姥鲛烷。高级脂肪酸的例子包括月桂酸、肉豆蔻酸、棕榈酸、硬脂酸、山榆酸、油酸、亚油酸、亚麻酸、羊毛脂肪酸和异硬脂酸。高级醇的例子包括月桂醇、鲸蜡醇、十八烷醇、油醇、羊毛脂醇、胆甾醇和2-己基癸醇。酯的例子包括鲸蜡基辛酸酯、甘油基三辛酸酯、肉豆蔻基乳酸、鲸蜡基乳酸、异丙基肉豆蔻脂、肉豆蔻基肉豆蔻脂、辛基十二烷基肉豆蔻脂、异丙基棕榈酸、异丙基己二酸、硬脂酸丁酯、癸基油酸酯、胆甾烯基异硬脂酸和聚氧乙烯(POE)山梨醇脂肪酸酯。香精油的例子包括薄荷油、茉莉油、樟脑油、日本扁柏油、橘皮油、黑麦油、松节油、肉桂油、香柠檬油、橘子油、白菖油、松油、熏衣草油、月桂叶油、丁子香油、日本罗汉柏油、玫瑰油、桉树油、柠檬油、百里香油、薄荷油、鼠尾草油、薄荷醇、桉树脑、丁子香酚、柠檬醛、香茅醛、龙脑、芳樟醇、香叶醇、樟脑、百里酚、千日菊酰胺、蒎烯、苎烯和萜烯混合物。硅油的例子包括二甲基聚硅氧烷。这些油性成分可以单独使用或者两个或几个组合使用。在本发明中,优先采用甘油基肉豆蔻酯、甘油基三(2-乙基己酸)、羊毛脂、液态石蜡、凡士林、石蜡微晶蜡、角鲨烷、月桂酸、肉豆蔻酸、棕榈酸、亚油酸、亚麻酸、异硬脂酸、鲸蜡醇、十八烷醇、油醇、胆甾醇、鲸蜡基辛酸酯、甘油基三辛酸酯、异丙基肉豆蔻酯、辛基十二烷基肉豆蔻酯、胆甾烯基异硬脂酸、POE山梨醇脂肪酸酯、薄荷油、橘皮油、肉桂油、玫瑰油、薄荷醇、桉树脑、丁子香酚、柠檬醛、香茅醛、香叶醛、蒎烯、苎烯和二甲基聚硅氧烷。The essential ingredient of the present invention is an oily ingredient. Examples of suitable oily ingredients include fats and oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, esters, essential oils and silicone oils. Examples of fats and oils include natural fats and oils such as soybean oil, bran oil (rice bran oil), jojoba oil, avocado oil, almond oil, olive oil, cocoa butter, safflower oil, sunflower oil, sesame oil, almond oil (almond oil), castor oil, palm oil, mink oil, tallow, and lard; hardened oils obtained from the hydrogenation of these natural fats and oils; and synthetic triglycerides such as trimyristin and tri(2-ethylglyceryl) hexanoic acid). Examples of waxes include carnauba wax, spermaceti, beeswax and lanolin. Examples of hydrocarbons include liquid paraffin, petrolatum, paraffin microcrystalline wax, ozokerite, squalane and pristane. Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, lanolin fatty acid, and isostearic acid. Examples of higher alcohols include lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol and 2-hexyldecanol. Examples of esters include cetyl caprylate, glyceryl tricaprylate, myristyl lactic acid, cetyl lactic acid, isopropyl myristate, myristyl myristate, octyldodecyl myristate butter, isopropyl palmitate, isopropyl adipate, butyl stearate, decyl oleate, cholestenyl isostearate and polyoxyethylene (POE) sorbitan fatty acid ester. Examples of essential oils include peppermint oil, jasmine oil, camphor oil, hinoki oil, orange peel oil, rye oil, turpentine oil, cinnamon oil, bergamot oil, orange oil, calamus oil, pine oil, lavender oil, Bay leaf oil, clove oil, Japanese cedar oil, rose oil, eucalyptus oil, lemon oil, thyme oil, peppermint oil, sage oil, menthol, cineole, eugenol, citral, citronellal, borneol , Linalool, Geraniol, Camphor, Thymol, Spilanthol, Pinene, Limonene and Terpene Blend. Examples of silicone oils include dimethylpolysiloxane. These oily ingredients may be used alone or in combination of two or more. In the present invention, glyceryl myristate, glyceryl tris (2-ethylhexanoic acid), lanolin, liquid paraffin, petrolatum, paraffin microcrystalline wax, squalane, lauric acid, myristic acid, palmitate Acid, Linoleic Acid, Linolenic Acid, Isostearic Acid, Cetyl Alcohol, Stearyl Alcohol, Oleyl Alcohol, Cholesteryl Alcohol, Cetyl Caprylate, Glyceryl Tricaprylate, Isopropyl Myristyl, Octyldodecyl Myristyl Ester, Cholesteryl Isostearic Acid, POE Sorbitan Fatty Acid Ester, Peppermint Oil, Orange Peel Oil, Cinnamon Oil, Rose Oil, Menthol, Eucalyptol, Eugenol, Lemon Aldehydes, Citronellal, Geranial, Pinene, Limonene, and Dimethicone.
油性成分优先包括了手指处理合成物的从约1%到约99%,更好地从约50%到约95%,最好地从约75%到约90%。基本不含成膜剂The oily component preferably comprises from about 1% to about 99%, more preferably from about 50% to about 95%, most preferably from about 75% to about 90%, of the finger treatment composition. Essentially free of film formers
本发明的手指处理合成物最好基本上不含成膜剂。一般说,这里所用的词语“基本上不含”意味着成膜剂的量级约1%或更少,更好约0.5%或更少,最好约0.1%或更少,甚至更好为0%或不大于0.05%。The finger treatment compositions of the present invention are preferably substantially free of film formers. Generally, the term "substantially free" as used herein means that the film former is present in an amount of about 1% or less, more preferably about 0.5% or less, most preferably about 0.1% or less, even more preferably 0% or not greater than 0.05%.
典型的成膜剂包括(但不限于):丙烯酰胺/丙烯酸钠共聚物;丙烯酸铵共聚物;秘鲁香脂;聚氨酯和聚氨酯衍生物,如脂族聚酯聚氨酯;纤维素树胶;纤维素聚合物(如硝化纤维之类的纤维素酯)、乙烯马来酐共聚物;羟乙基纤维素;羟丙基纤维素;聚丙烯酰胺;聚乙烯;聚乙烯醇;PVM/MA共聚物(聚乙烯甲基醚马来酐);PVP(聚乙烯吡咯烷酮);马来酐共聚物,如购自Gulf科技公司的PA-18;PVP/十六碳烯共聚物,如购自GAF公司的Ganex V-216;丙烯基丙烯基盐共聚物;等等。成膜剂的补充例子可在美国专利号5,639,447中找到,为了完整性引入这里作为参考。Typical film formers include (but are not limited to): acrylamide/sodium acrylate copolymers; ammonium acrylate copolymers; Peru balsam; polyurethanes and polyurethane derivatives such as aliphatic polyester polyurethanes; cellulose gums; Cellulose esters such as nitrocellulose), ethylene maleic anhydride copolymer; hydroxyethyl cellulose; hydroxypropyl cellulose; polyacrylamide; polyethylene; polyvinyl alcohol; PVM/MA copolymer (polyvinyl methyl base ether maleic anhydride); PVP (polyvinylpyrrolidone); maleic anhydride copolymers such as PA-18 from Gulf Technologies; PVP/hexadecene copolymers such as Ganex V-216 from GAF ; Propylene propenyl salt copolymer; and so on. Additional examples of film formers can be found in US Patent No. 5,639,447, incorporated herein by reference for completeness.
不受理论上的限制,可以认为成膜剂对表皮和指甲周围皮肤组织有不利影响。本发明人发现,成膜聚合物使皮肤感到干燥和发痒。本发明直接改进了皮肤的感觉(即软化和湿润了皮肤)和改进了皮肤的整个外观(即均匀了皮肤色调和减少了皮肤的“灰白”外观)。基本不含色素Without being bound by theory, it is believed that the film formers have an adverse effect on the epidermis and the skin tissue surrounding the nail. The inventors have found that film-forming polymers leave the skin feeling dry and itchy. The present invention directly improves the feel of the skin (ie, softens and moisturizes the skin) and improves the overall appearance of the skin (ie, evens out skin tone and reduces the "gray" appearance of the skin). basically no coloring
本发明的手指处理合成物最好基本上没有不含色素。一般说,这里所用的词语“基本上不含”意味着这种着色成分或色素的量级约0.1%或更少,更好约0.075%或更少,最好0%或不大于约0.05%。The finger treatment compositions of the present invention are preferably substantially free of pigments. Generally, the term "substantially free" as used herein means that such coloring ingredients or pigments are present in an amount of about 0.1% or less, more preferably about 0.075% or less, most preferably 0% or not more than about 0.05% .
典型的色素包括(但不限于)有机和无机色素和染料。有机色素一般是各种芳香族类型,包括偶氮、靛类、三苯甲烷、蒽醌和黄嘌呤染料,设计成D&C和FD&C蓝色、棕色、绿色、橘黄色、红色、黄色等。有机色素一般由合格颜色添加剂的不溶金属盐组成,称为色淀。无机色素包括氧化铁、群青和铬或氢氧化铬颜料,以及其混合物。Typical pigments include, but are not limited to, organic and inorganic pigments and dyes. Organic pigments are generally various aromatic types, including azo, indigo, triphenylmethane, anthraquinone, and xanthine dyes, designed as D&C and FD&C blue, brown, green, orange, red, yellow, etc. Organic pigments generally consist of insoluble metal salts of qualified color additives, called lakes. Inorganic pigments include iron oxide, ultramarine blue, and chromium or chromium hydroxide pigments, and mixtures thereof.
不受理论上的限制,可以认为色素对表皮和指甲周围皮肤组织的健康有不利影响,如使用者所感到那样。使用者通常避免对这些皮肤区域涂敷色素,以保持这些区域的健康和青春外观。Without being bound by theory, it is believed that the pigment has an adverse effect on the health of the cuticle and skin tissue surrounding the nail, as perceived by the user. Users typically avoid applying pigment to these areas of skin in order to maintain the healthy and youthful appearance of these areas.
选用成分Selected ingredients
本发明的手指处理合成物可以包含附加化妆品,它们通常用于这种配方中,例如防腐剂;如生物素、维生素B5及其衍生物(如羟泛酸)、维生素B3及其衍生物(如烟酰胺)。维生素E及其衍生物(如生育酚烟酸盐)、磷脂、α羟基酸(如乙二醇酸、乳酸)、β羟基酸(如水杨酸)、维生素A及其衍生物(如视黄酸和视黄酸酯)、维生素C和维生素D的护肤活性剂;杀菌剂;香水;阻膜剂;增稠剂;表面活性物质;乳化剂;增塑剂;湿化剂和/或湿润剂;所公布的基本成分之外的脂肪和蜡;或者如乙醇、多元醇或水的化妆品的其他常规成分;膜稳定剂;电解液;有机溶剂或硅衍生物。在1998年7月7日发布的Blank等的美国专利号5,776,918和1997年10月30日发布的Oblong等的PCT申请号WO 97/39733中,详细描述了这些和其他适当的选用成分,为了完整性引入这里作为参考。The finger treatment composition of the present invention may contain additional cosmetics, which are commonly used in such formulations, such as preservatives; such as biotin, vitamin B5 and its derivatives (such as pantothenic acid), vitamin B3 and its derivatives ( such as niacinamide). Vitamin E and its derivatives (such as tocopheryl nicotinate), phospholipids, alpha hydroxy acids (such as glycolic acid, lactic acid), beta hydroxy acids (such as salicylic acid), vitamin A and its derivatives (such as retinoic acid and retinoic acid esters), vitamin C and vitamin D; bactericides; perfumes; barrier agents; thickeners; surface active substances; emulsifiers; plasticizers; humectants and/or humectants; Fats and waxes other than the published essential ingredients; or other conventional ingredients of cosmetics such as alcohols, polyols or water; membrane stabilizers; electrolytes; organic solvents or silicon derivatives. These and other suitable optional ingredients are described in detail in U.S. Pat. Sex is incorporated here by reference.
当把水溶材料添加到本发明的手指处理合成物中时,合成物可以为含水油或含油水乳剂的形式。最好是,乳剂是含水油溶剂。处理和/或预防手指毛病的方法When water soluble materials are added to the finger treatment compositions of the present invention, the compositions may be in the form of aqueous oil or oil in water emulsions. Preferably, the emulsion is an aqueous oily solvent. Methods of treating and/or preventing finger disorders
处理和预防手指毛病的方法包括把安全和有效量的本发明手指处理合成物局部地涂到手指上,特别是指甲上。根据所希望的处理程度,如按照手指毛病的进展和其他症状变化速率,涂敷的合成物量、涂敷次数和使用时间将有很大变化。A method of treating and preventing finger disorders comprises topically applying to the fingers, especially the nails, a safe and effective amount of the finger treatment compositions of the present invention. The amount of composition applied, the number of applications and the duration of application will vary widely depending on the degree of treatment desired, eg, in terms of the rate of progression of finger disorders and other symptoms.
在一个优选实施例中,合成物长期地涂敷到手指上,特别是涂敷到指甲上。“长期局部涂敷”意味着在受疗者寿命中的一个很长时间上,连续地局部涂敷合成物,优先是至少约一个星期时间、更好是至少约一个月时间、甚至更好至少约三个月、甚至更好至少约六个月、以及更好至少约一年。尽管在各个最大使用期(如五年、十年或二十年)之后可得到效果,但最好长期涂敷延续到整个受疗者的寿命。典型的涂敷是在此延长期中每天约一次的量级,但涂敷的速率可以从每星期约一次变化到每天约三次或更多。In a preferred embodiment, the composition is applied chronically to the fingers, in particular to the nails. "Chronic topical application" means continuous topical application of the composition over a substantial period of the life of the subject, preferably for at least about a week, more preferably at least about a month, even more preferably at least About three months, even better at least about six months, and better at least about one year. Although effects may be obtained after respective maximum periods of use (eg, five, ten or twenty years), long-term application is preferably extended throughout the life of the subject. Typical application is on the order of about once per day for this extended period, but the rate of application can vary from about once per week to about three times per day or more.
可以采用本发明合成物的范围广泛的数量来提供手指和/或指甲的外观和/或感觉效果。通常每次涂敷的本发明合成物数量以(mg的合成物)/(cm2的皮肤和指甲)计算,从约0.1mg/cm2到约100mg/cm2。特别有用的涂敷量为约10mg/cm2。The compositions of the present invention may be employed in a wide range of amounts to provide finger and/or nail look and/or feel effects. Typically the amount of composition of the invention per application is calculated as (mg of composition)/(cm 2 of skin and nails), from about 0.1 mg/cm 2 to about 100 mg/cm 2 . A particularly useful application level is about 10 mg/cm 2 .
最好涂敷以油性合成物,或者含油水或含水油乳剂之类形式的合成物来实现本发明的方法,合成物用于留在皮肤上以得到某些美观的、预防的和治疗的或其他效果(即一种“留下”的合成物)。在把合成物涂敷到皮肤之后,优先留在皮肤上至少约15分钟时间,更好约至少30分钟,甚至更好约至少1小时,最好至少几个小时,如直到12小时。The methods of the present invention are preferably applied in the form of oily compositions, or compositions such as oil-in-water or water-in-oil emulsions, which are intended to be left on the skin to obtain certain cosmetic, preventive and therapeutic or Other effects (i.e. a "leave" composition). After application of the composition to the skin, it is preferably left on the skin for a period of at least about 15 minutes, more preferably at least about 30 minutes, even more preferably at least about 1 hour, most preferably at least several hours, such as up to 12 hours.
举例Example
在以下非限定性例子中说明了包括本发明发放装置和手指处理合成物的使用方法。熟练的技术人员可以进行其他的修改而不偏离本发明的精神和范围。采用本发明发放装置和手指处理合成物来举例的方法改进了湿润性和使用者与手指处理合成物的适应性。Methods of use comprising dispensing devices and finger treatment compositions of the present invention are illustrated in the following non-limiting examples. Other modifications can be made by skilled artisans without departing from the spirit and scope of the invention. The methods exemplified by the dispensing device and finger treatment composition of the present invention provide improved wettability and user compliance with the finger treatment composition.
可以采用常规的配方和混合技术来制备所有举例的合成物。列出的成分量为重量百分比,并且包括少量材料,如稀释剂、填充剂等。所以,所列的配方包括了列出的成分和与这些成分相关的任何少量材料。All exemplified compositions can be prepared using conventional formulation and mixing techniques. The listed ingredient amounts are percent by weight and include minor materials such as diluents, fillers, and the like. Therefore, listed formulations include the listed ingredients and any minor materials associated with those ingredients.
例IExample I
一种处理手指毛病的方法,采用了发放装置来涂敷以下油性合成物形式的手指处理合成物。A method of treating finger conditions employs a dispensing device to apply a finger treatment composition in the form of the following oily composition.
葵花籽油 25%
红花油 25%
豆油 25%
橄榄油 20%
维生素E生育酚 2%Vitamin E Tocopherol 2%
少量(防腐剂等) 3%A small amount (preservatives, etc.) 3%
把以上成分添加到不锈钢容器中,采用常规的混合技术彻底混合。然后把手指处理油装入发放装置中,并且采用发放装置涂敷到手指上,特别是涂敷到指甲和表皮上。Add the above ingredients to a stainless steel container and mix thoroughly using conventional mixing techniques. The finger treatment oil is then filled into the dispensing device and applied to the fingers, particularly the nails and cuticles, using the dispensing device.
例IIExample II
一种处理手指毛病的方法,采用了发放装置来涂敷以下含水油乳剂形式的手指处理合成物。A method of treating finger conditions employs a dispensing device to apply the following finger treatment composition in the form of an aqueous oil emulsion.
葵花籽油 23%
红花油 23%
豆油 25%
鲸蜡基双甲基共多羟基硅油(乳化剂) 0.5%Cetyl dimethyl copolyol (emulsifier) 0.5%
水 10%
甘油 10%
烟酸胺 2%Niacinamide 2%
少量(防腐剂等) 4.5%A small amount (preservatives, etc.) 4.5%
在装有热源的不锈钢容器中,混合油(葵花籽油、红花油和豆油)和乳化剂,并且伴随着搅拌加热到150F。在一个单独的不锈钢容器中,伴随着搅拌添加水、甘油、烟酸胺和防腐剂,并且混合到均匀。然后一起混合油和水混合物,伴随着搅拌冷却到室温。然后把手指处理乳剂装入发放装置并且采用发放装置涂敷手指上,特别是涂敷到指甲和表皮上。In a stainless steel vessel with a heat source, combine the oils (sunflower, safflower, and soybean) and emulsifier and heat to 150F with stirring. In a separate stainless steel container, add the water, glycerin, niacinamide, and preservative with stirring and mix until homogeneous. The oil and water mixture are then mixed together and cooled to room temperature with stirring. The finger treatment emulsion is then filled into the dispensing device and applied to the fingers, particularly the nails and cuticles, using the dispensing device.
Claims (10)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14662799P | 1999-07-30 | 1999-07-30 | |
| US60/146,627 | 1999-07-30 |
Publications (1)
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| CN1367658A true CN1367658A (en) | 2002-09-04 |
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| CN00811032A Pending CN1367658A (en) | 1999-07-30 | 2000-07-24 | Method for treating and preventing finger disorders |
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| EP (1) | EP1199955A2 (en) |
| JP (1) | JP2003505175A (en) |
| CN (1) | CN1367658A (en) |
| AU (1) | AU5838700A (en) |
| MX (1) | MXPA02001144A (en) |
| WO (1) | WO2001008529A2 (en) |
Cited By (1)
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| CN100431447C (en) * | 2004-09-02 | 2008-11-12 | 株式会社永青 | Applicator |
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| KR100445936B1 (en) * | 2001-10-11 | 2004-08-25 | 김종출 | Multipurpose case |
| ITMI20022154A1 (en) * | 2002-10-10 | 2004-04-11 | Gibo Italia Srl | COMPOSITE CONTAINER STRUCTURE, PARTICULARLY FOR COSMETICS. |
| CN100421596C (en) * | 2003-12-02 | 2008-10-01 | 株式会社常盘 | container with applicator |
| US20090175810A1 (en) | 2008-01-03 | 2009-07-09 | Gareth Winckle | Compositions and methods for treating diseases of the nail |
| US8039494B1 (en) | 2010-07-08 | 2011-10-18 | Dow Pharmaceutical Sciences, Inc. | Compositions and methods for treating diseases of the nail |
| BRPI1003698A2 (en) * | 2010-10-22 | 2013-02-19 | Antonio Carlos Wiezorkoski | Typical application of protective insulating film for finger area and finger nail fold |
| BRPI1003668A2 (en) * | 2010-10-22 | 2013-02-19 | Antonio Carlos Wiezorkoski | Cosmetic composition for the typical application of a protective insulating film to the epoxy area and finger nail fold |
| KR101779573B1 (en) * | 2010-11-04 | 2017-09-18 | 김종출 | Cosmetics vessel |
| US9339096B2 (en) * | 2013-02-21 | 2016-05-17 | Hct Packaging, Inc. | Cuticle care system |
| MX363386B (en) | 2013-10-03 | 2019-03-20 | Dow Pharmaceutical Sciences | Stabilized efinaconazole compositions. |
| CN105848719A (en) | 2013-11-22 | 2016-08-10 | 道尔医药科学公司 | Anti-infective methods, compositions, and devices |
| US20160058155A1 (en) | 2014-09-02 | 2016-03-03 | HCT Group Holdings Limited | Container with dispensing tip |
| WO2016044266A1 (en) | 2014-09-15 | 2016-03-24 | HCT Group Holdings Limited | Container with collapsible applicator |
| US9993059B2 (en) | 2015-07-10 | 2018-06-12 | HCT Group Holdings Limited | Roller applicator |
| USD818641S1 (en) | 2016-03-16 | 2018-05-22 | HCT Group Holdings Limited | Cosmetics applicator with cap |
| USD808822S1 (en) | 2016-07-22 | 2018-01-30 | HCT Group Holdings Limited | Cosmetics dispenser and applicator |
| FR3097727B1 (en) * | 2019-06-28 | 2021-07-16 | Oreal | Perfume applicator pen |
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| US1925140A (en) * | 1932-11-07 | 1933-09-05 | Ivan S Gardiner | Manicure implement |
| US2876782A (en) * | 1955-07-20 | 1959-03-10 | Richard B Despard | Dispensing container |
| US4049010A (en) * | 1976-03-10 | 1977-09-20 | Jovan, Inc. | Fingernail conditioning and polishing method and apparatus |
| US4033363A (en) * | 1976-04-14 | 1977-07-05 | Lawrence Peska Associates, Inc. | Cuticle instrument |
| US4810498A (en) * | 1986-02-13 | 1989-03-07 | The Peau Corporation | Nail oil composition |
| US5034215A (en) * | 1989-12-26 | 1991-07-23 | Santa Coloma Roth Nora | Cuticle and nail conditioning composition |
| AU3073692A (en) | 1991-11-25 | 1993-06-28 | Richardson-Vicks Inc. | Compositions for regulating skin wrinkles and/or skin atrophy |
| JP3105704B2 (en) * | 1993-07-16 | 2000-11-06 | 三菱鉛筆株式会社 | Liquid cosmetics |
| US5830640A (en) | 1995-03-07 | 1998-11-03 | George Washington University | Determining invasiveness of prostatic adenocarcinoma |
| US5639447A (en) | 1995-05-02 | 1997-06-17 | Mycone Dental Corporation | Quick-drying nail polish |
| AU3115097A (en) | 1996-04-23 | 1997-11-12 | Procter & Gamble Company, The | Methods of regulating skin condition with centella asiatica extract |
| JP3922744B2 (en) | 1996-09-09 | 2007-05-30 | 三菱鉛筆株式会社 | Liquid applicator |
| US5851079A (en) * | 1996-10-25 | 1998-12-22 | The Procter & Gamble Company | Simplified undirectional twist-up dispensing device with incremental dosing |
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2000
- 2000-07-24 EP EP00944155A patent/EP1199955A2/en not_active Withdrawn
- 2000-07-24 WO PCT/IB2000/001019 patent/WO2001008529A2/en not_active Ceased
- 2000-07-24 CN CN00811032A patent/CN1367658A/en active Pending
- 2000-07-24 AU AU58387/00A patent/AU5838700A/en not_active Abandoned
- 2000-07-24 MX MXPA02001144A patent/MXPA02001144A/en unknown
- 2000-07-24 JP JP2001513273A patent/JP2003505175A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100431447C (en) * | 2004-09-02 | 2008-11-12 | 株式会社永青 | Applicator |
Also Published As
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| AU5838700A (en) | 2001-02-19 |
| EP1199955A2 (en) | 2002-05-02 |
| WO2001008529A3 (en) | 2001-08-23 |
| WO2001008529A2 (en) | 2001-02-08 |
| MXPA02001144A (en) | 2002-08-20 |
| JP2003505175A (en) | 2003-02-12 |
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