CN1235618C - Chinese-medicinal aqueogel for treating burn and its preparing process - Google Patents
Chinese-medicinal aqueogel for treating burn and its preparing process Download PDFInfo
- Publication number
- CN1235618C CN1235618C CN 02111762 CN02111762A CN1235618C CN 1235618 C CN1235618 C CN 1235618C CN 02111762 CN02111762 CN 02111762 CN 02111762 A CN02111762 A CN 02111762A CN 1235618 C CN1235618 C CN 1235618C
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- CN
- China
- Prior art keywords
- chinese medicine
- preparation
- medicine extract
- aqueogel
- gauze
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000003814 drug Substances 0.000 claims abstract description 24
- 238000002360 preparation method Methods 0.000 claims abstract description 20
- 239000000284 extract Substances 0.000 claims abstract description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 12
- 238000002791 soaking Methods 0.000 claims description 9
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 5
- 235000010413 sodium alginate Nutrition 0.000 claims description 5
- 239000000661 sodium alginate Substances 0.000 claims description 5
- 229940005550 sodium alginate Drugs 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 4
- 239000012153 distilled water Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
- 238000011017 operating method Methods 0.000 claims 1
- 206010052428 Wound Diseases 0.000 abstract description 9
- 208000027418 Wounds and injury Diseases 0.000 abstract description 9
- 239000002674 ointment Substances 0.000 abstract description 3
- 239000006072 paste Substances 0.000 abstract description 3
- 230000001953 sensory effect Effects 0.000 abstract description 3
- 230000000202 analgesic effect Effects 0.000 abstract description 2
- 230000001139 anti-pruritic effect Effects 0.000 abstract description 2
- 239000003908 antipruritic agent Substances 0.000 abstract description 2
- 230000023597 hemostasis Effects 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 abstract description 2
- 230000029663 wound healing Effects 0.000 abstract description 2
- 239000000017 hydrogel Substances 0.000 abstract 2
- 241000037740 Coptis chinensis Species 0.000 abstract 1
- 241000972672 Phellodendron Species 0.000 abstract 1
- 241001648835 Polygonum cuspidatum Species 0.000 abstract 1
- 235000018167 Reynoutria japonica Nutrition 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 239000003610 charcoal Substances 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 7
- 239000000843 powder Substances 0.000 description 3
- 206010040943 Skin Ulcer Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- 231100000019 skin ulcer Toxicity 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及医药技术领域，是一种治疗烧伤创面的中药提取物水凝胶制剂及其制备方法。本发明从黄连、川黄柏、地榆炭、刘寄奴、虎杖中提取有效成分，制成水凝胶制剂，与同类中药制剂的油剂、膏剂、糊剂相比，本发明具有制备方法简单，使用方便，感官性状好等优点。经临床试用，其具有抗菌消炎、解热镇痛、止血化瘀、促进创面愈合、止痒等作用，是治疗烧伤创面的良药。The invention relates to the technical field of medicine, and relates to a traditional Chinese medicine extract hydrogel preparation for treating burn wounds and a preparation method thereof. The present invention extracts active ingredients from Coptis chinensis, Chuan Phellodendron, Burnet charcoal, Liu Jinu, and Polygonum cuspidatum to make a hydrogel preparation. Compared with oils, ointments, and pastes of similar Chinese medicine preparations, the present invention has simple preparation methods , easy to use, good sensory properties and so on. According to clinical trials, it has the functions of antibacterial and anti-inflammatory, antipyretic and analgesic, hemostasis, promoting wound healing, and antipruritic. It is a good medicine for treating burn wounds.
Description
Technical field: the present invention relates to medical technical field, is a kind of Chinese medicine extract aqueogel that is used for burn wound's treatment and preparation method thereof.
Background technology: burn wound is the crux of burn patient whole body or localized variation, can threaten patient's life in severe case.Thereby, actively promote wound repair to save patient's life, reduce complication, to improve therapeutic effect significant.Motherland's medical science extensive knowledge and profound scholarship has accumulated rich experience aspect burn treating, some proved recipe has demonstrated effect preferably in the deep burn treatment.The Chinese medicine preparation that is used for burn wound at present mostly is oil preparation, unguentum, paste or powder etc., and sensory properties is relatively poor, uses inconvenience, pollutes dressing, sheet bedding and medicated clothing easily.
Summary of the invention: the modern Chinese medicine pharmaceutical research shows that Rhizoma Coptidis has eliminating fire and detoxication, heat clearing and damp drying effect; Cortex Phellodendri has heat clearing and damp drying, pathogenic fire purging removes and steams, detoxifies and treat the skin ulcer effect; Charred Radix Sanguisorbae has cooling blood for hemostasis, the skin ulcer effect is held back in detoxifcation; Herba Artemisiae Anomalae has clearing away summer-heat and eliminating dampness, blood circulation promoting competent silt, inducing menstruation to relieve menalgia effect; Rhizoma Polygoni Cuspidati has the analgesic therapy of invigorating blood circulation, eliminating damp-heat, relieving cough and resolving phlegm effect, and Mentholum has itching-relieving action.The pharmacological action of these Chinese medicines conforms to the requirement of burn wound's treatment.The present invention is prepared into the sodium alginate aqueogel from Rhizoma Coptidis, Cortex Phellodendri, charred Radix Sanguisorbae, Herba Artemisiae Anomalae, Rhizoma Polygoni Cuspidati effective component extracting, is used for the treatment of burn wound.Compare with oil preparation, unguentum, paste, the powder of similar Chinese medicine preparation, the present invention has the advantages such as pollution that preparation method is simple, easy to use, sensory properties is good, be convenient to clean, be difficult for causing dressing, sheet bedding and medicated clothing.Clinic trial result shows, preparation of the present invention has anti-inflammation, antipyretic-antalgic, hemostasia and dissipation blood stasis, promotion wound healing, effect such as antipruritic, is the good medicine of treatment burn wound.
Preparation method of the present invention is:
1. prepare the Chinese medicine extract concentrated solution: get equivalent Rhizoma Coptidis, Cortex Phellodendri, charred Radix Sanguisorbae, Herba Artemisiae Anomalae, Rhizoma Polygoni Cuspidati raw medicinal material, it is pulverized, put in the chloroform of 2 times of volumes with mechanical means, soaking at room temperature 12 hours, filtered through gauze repeats merging filtrate 2 times; 95% ethanol of 2 times of volumes of filtering residue reuse, soaking at room temperature 12 hours, filtered through gauze repeats merging filtrate 2 times; Use the distilled water of 2 times of volumes at last, soaking at room temperature filtering residue 12 hours, filtered through gauze repeats merging filtrate 2 times.Above-mentioned filtrate combines behind the concentrating under reduced pressure respectively, is the Chinese medicine extract concentrated solution.
2. preparation Chinese medicine extract aqueogel: in above-mentioned Chinese medicine extract concentrated solution, add glycerol (amount of glycerol be final volume 30～40%), calcium chloride solution and sodium alginate successively, the attention addition sequence can not be put upside down, stir into even heavy-gravity gel, get the Chinese medicine extract aqueogel.
The specific embodiment:
Embodiment 1: gets Rhizoma Coptidis, Cortex Phellodendri, charred Radix Sanguisorbae, Herba Artemisiae Anomalae, each 20g of Rhizoma Polygoni Cuspidati raw medicinal material, it pulverized, add the chloroform of 2 times of volumes with mechanical means, and soaking at room temperature 12 hours, filtered through gauze repeats merging filtrate, concentrating under reduced pressure 2 times; 95% ethanol that adds 2 times of volumes in the filtering residue, soaking at room temperature 12 hours, filtered through gauze repeats merging filtrate, concentrating under reduced pressure 2 times; The distilled water that adds 2 times of volumes in the filtering residue again, soaking at room temperature 12 hours, filtered through gauze repeats merging filtrate, concentrating under reduced pressure 2 times.Merge all filtrates, be evaporated to final volume 350ml.In concentrated solution, add glycerol 150ml, 1mol/L CaCl
2Solution 10ml, sodium alginate 10g stirs, and makes sodium alginate be swelled into even, heavy-gravity gel.In addition Mentholum 3g is ground into fine powder, joins in the gel, stir, promptly get Chinese medicine extract aqueogel 500ml.
Claims (3)
1. preparation method for the treatment of the Chinese medicine extract aqueogel of burn wound, operating procedure is as follows:
(1). preparation Chinese medicine extract concentrated solution: get equivalent Rhizoma Coptidis, Cortex Phellodendri, charred Radix Sanguisorbae, Herba Artemisiae Anomalae, Rhizoma Polygoni Cuspidati raw medicinal material, it is pulverized, put in the chloroform of 2 times of volumes with mechanical means, soaking at room temperature 12 hours, filtered through gauze repeats merging filtrate 2 times; 95% ethanol soaking at room temperature of 2 times of volumes of filtering residue reuse 12 hours, filtered through gauze repeats merging filtrate 2 times; Use the distilled water of 2 times of volumes at last, soaking at room temperature filtering residue 12 hours, filtered through gauze repeats 2 times, merging filtrate, above-mentioned filtrate combines behind the concentrating under reduced pressure respectively, is the Chinese medicine extract concentrated solution;
(2). preparation Chinese medicine extract aqueogel: in above-mentioned Chinese medicine extract concentrated solution, add glycerol, calcium chloride solution and sodium alginate successively, stir into even heavy-gravity gel.
2. the Chinese medicine extract aqueogel that makes of the described preparation method of claim 1.
3. the application of the described Chinese medicine extract aqueogel of claim 2 in preparation treatment burn wound medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02111762 CN1235618C (en) | 2002-05-21 | 2002-05-21 | Chinese-medicinal aqueogel for treating burn and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02111762 CN1235618C (en) | 2002-05-21 | 2002-05-21 | Chinese-medicinal aqueogel for treating burn and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1382475A CN1382475A (en) | 2002-12-04 |
| CN1235618C true CN1235618C (en) | 2006-01-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02111762 Expired - Fee Related CN1235618C (en) | 2002-05-21 | 2002-05-21 | Chinese-medicinal aqueogel for treating burn and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1235618C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311378A (en) * | 2014-07-07 | 2016-02-10 | 徐海防 | Burn treatment medicine and preparation method thereof |
| CN104491108B (en) * | 2014-12-30 | 2017-04-26 | 西安交通大学 | Preparation method and application of traditional Chinese medicinal hydrogel |
| WO2017059255A1 (en) * | 2015-10-01 | 2017-04-06 | PhotoDynamic Inc. | Novel polygonum cuspidatum extracts and their use as photodynamic inactivating agents |
| CN109793918B (en) * | 2018-12-29 | 2021-02-12 | 中国人民解放军总医院 | Plant composite dressing capable of promoting large-area wound hair follicle regeneration |
| CN111166930A (en) * | 2019-11-19 | 2020-05-19 | 北京理工大学 | Sodium alginate hydrogel medical dressing and preparation method thereof |
-
2002
- 2002-05-21 CN CN 02111762 patent/CN1235618C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1382475A (en) | 2002-12-04 |
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