CN120801735A

CN120801735A - Cell image analysis system and slide storage method thereof

Info

Publication number: CN120801735A
Application number: CN202511248421.0A
Authority: CN
Inventors: 姜斌; 苏晓冬; 周慕昭; 陈海云
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2020-07-31
Filing date: 2021-05-18
Publication date: 2025-10-17
Also published as: CN114062698A; CN114062698B

Abstract

The invention provides a cell image analysis system and a slide storage method thereof, wherein the system comprises a first slide box, a control device, a slide loading device, a detection platform, an imaging device, a slide unloading device and a second slide box, wherein the first slide box is used for loading a slide to be detected, the control device controls the slide loading device to load the slide to be detected in the first slide box to the detection platform, the detection platform is used for carrying the slide to be detected for detection, the imaging device controls the imaging device to shoot cells of a sample in the slide to be detected on the detection platform, the shot slide to be detected is the detected slide, the slide unloading device controls the slide unloading device to unload the detected slide from the detection platform to the second slide box, and the second slide box is used for loading the detected slide, and the capacity of the second slide box is larger than that of the first slide box. The system and the method greatly reduce the times of frequent replacement of the slide box by a user, avoid the blockage of the slide caused by the filling of the slide box, and greatly improve the storage efficiency of the slide.

Description

Cell image analysis system and slide storage method thereof

The application is a divisional application of Chinese application patent application with the application number of 202110540914.7. The application date of the original application is 2021, 05 and 18, and the application is named as a cell image analysis system and a slide storage method thereof.

Technical Field

The present invention relates to the field of medical technology, and more particularly to slide storage.

Background

When analyzing the cell morphology, the cell image analysis device needs to place a plurality of slides in a temporary storage container (such as a slide basket) so as to realize the transmission and the transportation of the slides and improve the transmission efficiency and the transmission convenience. The slide basket carries a plurality of slides and is conveyed to a sample injection channel of the cell image analysis device, and the cell image analysis device clamps the slides into the cell image analysis device one by one for cell fractal analysis. The inspected slides are returned to the slide basket or to another slide basket, and then the inspected slides are collectively placed and stored for later review.

However, the current slide basket has smaller capacity, the whole slide basket is quickly filled with the inspected slide, and a user is required to frequently take the filled slide basket, otherwise, the cell image analysis device is blocked to stop. In addition, the slide storage density in the slide basket is low, and is not suitable for long-term storage of slides, so that a user is required to manually take out and put the slides one by one into other slide storage containers which can be closely put in a plurality of slide storage containers, which causes time and effort for an operator to frequently perform the operation every day, and if the taking is delayed, the slides are blocked, and the cell image analysis apparatus is suspended.

In addition, the existing recycling slide basket is only opened at one side, so that the recycling of the slide into the slide basket and the taking out of the slide from the recycling slide basket are realized at the same side, the cleaning of the slide is troublesome, the usability is poor, and the user experience is poor. And the lens oil can be remained on the blood smear after analysis, the existing slide basket for recycling has no functions of oil proofing, oil guiding and oil collecting, and the greasy dirt residue is serious after long-term use, so that the repeated use is influenced.

Disclosure of Invention

The embodiment of the invention provides a cell image analysis system on a repositioning smear and a slide storage method thereof, which are used for solving at least one of the problems.

According to a first aspect of the present invention there is provided a cell image analysis system, the system comprising:

the first glass slide box is used for loading glass slides to be tested;

A control device;

The control device controls the slide loading device to load the slide to be detected in the first slide box to the detection platform;

The detection platform is used for bearing the slide to be detected for detection;

The control device controls the imaging device to shoot cells of a sample in the slide to be detected on the detection platform, and the slide to be detected after shooting is a detected slide;

A slide unloading device, the control device controlling the slide unloading device to unload the tested slide from the detection platform to a second slide box;

The second slide box is used for loading the tested slide, and the capacity of the second slide box is larger than that of the first slide box.

According to a second aspect of the present invention there is provided a cell image analysis system, the system comprising:

A control device;

the slide loading device is used for loading the slide to be detected to the detection platform;

The imaging device is used for shooting cells of a sample in the slide to be detected on the detection platform, and the slide to be detected after shooting is a detected slide;

Slide unloading means for unloading the slide from the detection platform into a recovery slide cassette;

the recovery slide cassette is configured to hold at least 20, 40, 60, 80, or 100 slides.

According to a third aspect of the present invention, there is provided a slide storage method of a cell image analysis system, the method comprising:

sequentially acquiring slides to be detected from the first slide box and loading the slides to be detected onto a detection platform;

Detecting a sample in the slide to be detected on the detection platform, wherein the detected slide to be detected is a detected slide;

Unloading the detected slide from the detection platform to corresponding areas in a plurality of preset areas of a second slide box according to sample attributes of the detected slide, wherein the plurality of preset areas are set by a user according to the sample attributes;

The second slide cassette carries a tested slide from a plurality of the first slide cassettes.

According to the cell image analysis system and the slide storage method thereof, through directly placing the detected slide into the slide box with large capacity and storing the slide for a long time, the times of frequent replacement of the slide box by a user are greatly reduced, the slide blockage caused by filling the slide box is avoided, the slide box with large capacity is directly used for storing the slide for a long time, the detected slide is not manually transferred into a long-term storage container, and the storage efficiency of the slide is greatly improved.

Drawings

The above and other objects, features and advantages of the present invention will become more apparent from the following more particular description of embodiments of the present invention, as illustrated in the accompanying drawings. The accompanying drawings are included to provide a further understanding of embodiments of the invention and are incorporated in and constitute a part of this specification, illustrate the invention and together with the embodiments of the invention, and not constitute a limitation to the invention. In the drawings, like reference numerals generally refer to like parts or steps.

FIG. 1a shows an example of a slide basket;

FIG. 1b shows an example of a slide storage container;

FIG. 2 is a schematic diagram of a cell image analysis system according to an embodiment of the present invention;

Fig. 3a and 3b are examples of slide placement directions according to embodiments of the present invention;

Fig. 4 is a schematic structural view of a control device according to an embodiment of the present invention;

Fig. 5 a-5 c are examples of slide loading devices according to embodiments of the present invention;

fig. 6 a-6 c are examples of slide loading devices according to embodiments of the invention;

FIG. 7 is a schematic diagram of a further construction of a cell image analysis system according to an embodiment of the present invention;

FIGS. 8 a-8 c are examples of slide unloading devices according to embodiments of the invention;

fig. 9 a-9 c are examples of slide unloading devices according to embodiments of the invention;

FIGS. 10 a-10 d illustrate a slide storage mode;

FIGS. 11a and 11b are examples of a single row of second slide cassettes in accordance with an embodiment of the invention;

FIGS. 12a and 12b are examples of a second slide cassette arranged in double rows according to an embodiment of the invention;

FIG. 13 is an example of a third row of arranged second slide cassettes in accordance with an embodiment of the invention;

fig. 14a and 14b are examples of preset areas of a second slide cassette according to an embodiment of the invention;

15 a-15 c are examples of slides that are spaced apart in accordance with embodiments of the invention;

fig. 16 is an example in which a second slide cassette is displayed in a display section according to an embodiment of the present invention;

FIG. 17 is a schematic perspective view from the left of a second slide cassette according to an embodiment of the invention;

FIG. 18 is a schematic perspective view of the second slide cassette of FIG. 17 from the right side;

FIG. 19 is another schematic perspective view of the second slide cassette of FIG. 17 from the left;

FIG. 20 is a schematic perspective view of a receptacle according to an embodiment of the invention;

FIG. 21 is a schematic perspective view of a side panel of a second slide cassette according to an embodiment of the invention;

FIG. 22 is a partial perspective view of a second slide cassette according to an embodiment of the invention;

FIG. 23 is a schematic view showing a structure of a recovery slide cassette (single row slot set) for storing a detected sample slide according to another embodiment of the present invention;

FIGS. 24 and 25 are schematic views showing the structure of a recycling slide cassette (double row slot set) for storing a detected slide according to another embodiment of the present invention at different angles;

FIG. 26 is a schematic illustration of a sample slide being tilted within a slot in an embodiment of the invention;

FIG. 27 is a schematic diagram of the location of a readable element and guide information in an embodiment of the invention;

fig. 28 is a schematic flow chart of a slide storage method of a cellular image analysis system according to an embodiment of the invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, exemplary embodiments according to the present invention will be described in detail with reference to the accompanying drawings. It should be apparent that the described embodiments are only some embodiments of the present invention and not all embodiments of the present invention, and it should be understood that the present invention is not limited by the example embodiments described herein. Based on the embodiments of the invention described in the present application, all other embodiments that a person skilled in the art would have without inventive effort shall fall within the scope of the invention.

In the current cell image analysis process, a slide basket for storing slides is generally small in volume and accommodates only a few or so slides, as shown in fig. 1a, and fig. 1a shows an example of a slide basket. Moreover, in order to achieve machine-to-slide clamping and placement operations, the inter-slide spacing is relatively large, so the density at which the slide basket can hold slides is low. If the existing slide baskets are used for storing the slides after analysis, users are required to frequently take the fully-filled slide baskets, otherwise, the machine is blocked to stop, and the efficiency of cell image analysis is greatly reduced.

Based on the above considerations, a cell image analysis system is provided according to an embodiment of the present invention. Referring to fig. 2, fig. 2 shows a schematic diagram of the structure of a cell image analysis system according to an embodiment of the present invention. As shown in fig. 2, the system 200 includes:

A first slide cassette 210 for loading slides to be measured;

A control device 220;

a slide loading device 230, wherein the control device 220 controls the slide loading device 230 to load the slide to be tested in the first slide box 210 to a test platform 240;

The detection platform 240 is used for carrying the slide to be detected for detection;

The imaging device 250 controls the imaging device 250 to shoot cells of a sample in the slide to be detected on the detection platform, and the slide to be detected after shooting is a detected slide;

A slide unloading device 260, the control device 220 controlling the slide unloading device 260 to unload the tested slide from the test platform into a second slide cassette 270;

The second slide cassette 270 is used for loading the tested slide, and the capacity of the second slide cassette 270 is larger than that of the first slide cassette 210.

The cell image analysis system of the embodiment of the invention directly places the detected glass slide into the second glass slide box with the capacity larger than that of the first glass slide box for storing the glass slide to be detected, so that the large-capacity second glass slide box can accommodate the glass slides from the plurality of first glass slide boxes, and users do not need to replace the fully-filled second glass slide boxes frequently.

In addition, conventional slide baskets are not suitable for long-term storage of slides because of the low slide storage density. In practical applications, medical institutions such as hospitals require 2 weeks up to 2 years of archiving backups of slides. If a conventional slide basket is used to store the slides, there is a significant requirement for storage space. It is generally necessary for a user to manually remove one by one and place it into another slide storage container in which multiple slides may be closely placed, as shown in fig. 1b, an example of which is shown in fig. 1 b. This process takes up significant time and effort from the user and if delayed a little, can cause the slide to clog and stop, further compromising the storage of the tested slide.

However, in the system for analyzing a cell image provided by the embodiment of the present invention, the second slide box may also be directly used as a storage container. Therefore, the user can directly use the second slide box containing the tested slide for long-term storage without manually moving the tested slide into the long-term storage container, so that the workload and error rate of the user are greatly reduced, the slide is prevented from being damaged or lost due to manual misoperation, and meanwhile, the efficiency of storing the slide can be improved by directly using the second slide box for long-term storage.

Thus, the second cassette can be placed in the cellular image analysis system as a temporary storage module for the slide, and can be removed from the cellular image analysis system as a long-term storage container for the slide.

Optionally, the slides in the first slide cassette 210 and/or the second slide cassette 270 may be placed vertically or horizontally. Referring to fig. 3a and 3b, fig. 3a and 3b illustrate examples of slide placement directions according to embodiments of the present invention. In fig. 3a, the slide is placed vertically, and in fig. 3b, the slide is placed horizontally.

In some embodiments, the first slide cassette 210 is configured to hold at least 10 slides.

It should be appreciated that the slide placement directions in the first slide cassette and the second slide cassette may be the same or different, and are not limited herein.

Alternatively, referring to fig. 4, fig. 4 shows a schematic structural view of a control device according to an embodiment of the present invention. As shown in fig. 4, the control device 220 includes at least a processing component 431, a RAM432, a ROM433, a communication interface 434, a memory 436, and an I/O interface 435, wherein the processing component 431, the RAM432, the ROM433, the communication interface 434, the memory 436, and the I/O interface 435 may communicate through a bus 437.

The processing component 431 may be implemented by software, hardware, firmware, or a combination thereof, and may use at least one of a Circuit, a single or multiple Application-specific integrated circuits (ASIC), a digital signal Processor (DIGITAL SIGNAL Processor, DSP), a digital signal processing device (DIGITAL SIGNAL Processing Device, DSPD), a programmable logic device (Programmable Logic Device, PLD), a field programmable gate array (Field Programmable GATE ARRAY, FPGA), a central processing unit (Central Processing Unit, CPU), a controller, a microcontroller, a microprocessor, or a combination thereof, so that the processing component 431 may perform part or all of the steps in the cellular image analysis method and the slide storage method thereof or any combination of the steps therein in the various embodiments of the present application.

The memory 436 contains various computer programs such as an operating system and application programs for execution by the processor component 431 and data necessary for execution of the computer programs. In addition, during sample detection, data that is stored locally, if desired, may be stored in memory 436.

In some embodiments, memory 436 may be volatile memory or nonvolatile memory, and may include both volatile and nonvolatile memory. The non-volatile Memory may be, among other things, a Read Only Memory (ROM), a programmable Read Only Memory (PROM, programmable Read-Only Memory), erasable programmable Read-Only Memory (EPROM, erasable Programmable Read-Only Memory), electrically erasable programmable Read-Only Memory (EEPROM, ELECTRICALLY ERASABLE PROGRAMMABLE READ-Only Memory), Magnetic random access Memory (FRAM, ferromagnetic random access Memory), flash Memory (Flash Memory), magnetic surface Memory, optical disk, or compact disk-Only Memory (CD-ROM, compact Disc Read-Only Memory), which may be disk Memory or tape Memory. The volatile memory may be random access memory (RAM, random Access Memory) which acts as external cache memory. by way of example and not limitation, many forms of RAM are available, such as static random access memory (SRAM, static Random Access Memory), synchronous static random access memory (SSRAM, synchronous Static Random Access Memory), dynamic random access memory (DRAM, dynamic Random Access Memory), synchronous dynamic random access memory (SDRAM, synchronous Dynamic Random Access Memory), and, Double data rate synchronous dynamic random access memory (DDRSDRAM, double Data Rate Synchronous Dynamic Random Access Memory), enhanced synchronous dynamic random access memory (ESDRAM, enhanced Synchronous Dynamic Random Access Memory), synchronous link dynamic random access memory (SLDRAM, syncLink Dynamic Random Access Memory), Direct memory bus random access memory (DRRAM, direct Rambus Random Access Memory). the memory 436 described in embodiments of the present invention is intended to comprise these and any other suitable types of memory.

The I/O interface 435 is constituted by a serial interface such as USB, IEEE1394, or RS-232C, a parallel interface such as SCSI, IDE, or IEEE1284, and an analog signal interface composed of a D/a converter, an a/D converter, and the like. An input device including a keyboard, mouse, trackball, click wheel, keys, buttons, touch pad, touch screen, or other control means is connected to the I/O interface 435, and a user can directly input data to the control device 130 using the input device. The I/O interface 435 may be connected to a display having a display function, such as a liquid crystal display, a touch panel, an LED display, etc., and the control device 220 may output the processed data as image display data to the display for display, such as a cell image, analysis data, instrument operation parameters, etc.

Communication interface 434 is an interface that may be any communication protocol. The communication interface 434 communicates with the outside through a network. The control device 220 may communicate data with any device connected via the network via the communication interface 434 in a communication protocol. It should be understood that the sample analysis system according to the embodiment of the present invention is not limited by the communication interface, and whether the interface is an interface of a now known communication protocol or an interface of a communication protocol developed in the future can be used in the cell image analysis system according to the embodiment of the present invention to realize a function of communicating with the outside through a network, which is not limited herein.

When the cell image analysis system according to the embodiment of the invention is operated, a corresponding operation interface can be provided for an operator to operate, and the operation interface can comprise corresponding controls, such as a mark selection box or a menu bar, so that the operator can input an operation instruction on the operation interface according to actual use conditions, and the analysis of cells on a sample slide by the cell image analysis system is realized.

Alternatively, the first and second cassettes 210 and 270 are disposed on both sides of the imaging device 250 or the inspection platform 240, respectively.

In some embodiments, when the first slide cassette 210 and the second slide cassette 270 are disposed on two sides of the imaging device 250, the slide loading device 230 clips a slide to be tested from the first slide cassette 210, moves and loads the slide onto the testing platform 240, takes the slide as a tested slide after being imaged by the imaging device 250, and clips, moves and unloads the slide into the second slide cassette by the slide unloading device 260.

In some embodiments, when the first slide cassette 210 and the second slide cassette 270 are disposed on two sides of the detection platform 240, the slide loading device 230 clips a slide to be detected from the first slide cassette 210, loads the slide onto the detection platform 240, takes the slide as a detected slide after shooting by the imaging device 250, and clips and unloads the slide to the second slide cassette by the slide unloading device 260.

Alternatively, the slide loading device 230 may be coupled to a transfer rail for transporting slides to be measured (e.g., slides to be measured prepared by a slide preparation device) from other equipment to the cell image analysis system 200, or the slide loading device 230 may be uncoupled from an external rail, in which case a user may directly place slides to be measured in the first slide cassette 210.

Alternatively, the slide loading device 230 may include a mechanical transfer section that automatically places a slide to be tested to a slide input module that loads the slide to be tested to the test platform, and a slide input module.

The mechanical conveying part automatically loads the slide to be detected, so that the processing speed of the system can be increased, the workload of a user (such as medical staff) is reduced, and the slide input module can cache the slide to be detected.

In some embodiments, referring to fig. 5a, fig. 5a shows an example of a slide loading device according to an embodiment of the invention. In fig. 5a, the slide loading device 530 includes a mechanical transfer portion 531 and a slide input module 532, where the mechanical transfer portion 531 may be implemented as a mechanical arm, for example, and the mechanical arm clamps the slide 533 to be tested from the slide to be tested vertically placed in the first slide box upward, horizontally and/or vertically, and then turns over to clamp the slide to be tested to the slide input module 532.

In other embodiments, referring to fig. 5b, fig. 5b shows yet another example of a slide loading device according to an embodiment of the invention. In fig. 5b, the slide loading device 530 comprises a mechanical transfer part 531 and a slide input module 532, wherein the mechanical transfer part 531 may be implemented as a mechanical arm, for example, and the mechanical arm clamps the slide 533 to be tested from the slide to be tested horizontally placed in the first slide box, and the slide to be tested is clamped to the slide input module 532 after being horizontally and/or vertically moved and turned over.

It should be appreciated that in the above embodiment, when the distance between the first slide cassette and the slide input module is relatively short (e.g., less than or equal to a predetermined value), the mechanical arm does not need to hold the slide horizontally and/or vertically, and the mechanical arm may omit the horizontal and/or vertical movement, and directly flip onto the slide input module after holding the slide to be measured placed vertically or horizontally.

In some embodiments, referring to fig. 5c, fig. 5c shows yet another example of a slide loading device according to an embodiment of the invention. In fig. 5c, the mechanical transfer section may also be implemented, for example, as a pushing device (not shown) that pushes or pulls the slide 533 to be tested horizontally from the slide horizontally placed in the first cassette directly to the slide input module 532.

In some embodiments, the slide input module 532 transfers slides to be tested placed thereon to the test platform. Further, the slide input module 532 may be configured to transport the slide to be measured to a position on the test platform facing the imaging device via a belt.

Optionally, the slide loading device 230 may also include only a mechanical transfer section. In this way, the detection efficiency can be further improved, and the volume of the cell image analysis system can be reduced.

In some embodiments, referring to fig. 6a, fig. 6a shows an example of a slide loading device according to an embodiment of the invention. In fig. 6a, the slide loading device 630 includes a mechanical transfer part 631, where the mechanical transfer part 631 may be implemented, for example, as a mechanical arm, and the mechanical arm clamps the slide 632 to be tested from the slide to be tested vertically placed in the first slide box upwards, and after moving horizontally and/or vertically, turns over, and clamps the slide to be tested to the test platform.

In other embodiments, referring to fig. 6b, fig. 6b shows yet another example of a slide loading device according to an embodiment of the present invention, a robot arm 631 clamps a slide 632 to be tested from a slide horizontally placed in a first slide cassette, and after horizontal and/or vertical movement, is flipped over to clamp the slide to be tested to the test platform.

In some embodiments, referring to fig. 6c, fig. 6c shows yet another example of a slide loading device according to an embodiment of the invention. In fig. 6c, the mechanical transfer unit may also be implemented, for example, as a pushing device (not shown) that pushes or pulls the slide 632 to be tested horizontally from the slide to be tested horizontally placed in the first cassette directly to the test platform.

Optionally, the detection platform 240 may include:

Slide movement means 241 for moving and fixing the slide with respect to the imaging means 250 so that the imaging means 250 takes a cell image of a specific region of the slide.

In some embodiments, the slide movement device may be provided with a fixture (e.g., a clamp) for clamping the smear to keep the position stable.

In some embodiments, the detection platform 240 may be located below the imaging device 250. When the slide device loads the slide to be detected on the detection platform, the imaging device positioned above the detection platform can shoot the slide to obtain a cell image of a sample in the slide.

In some embodiments, the shape of the detection platform includes, but is not limited to, square, circular rows. The position of the slide placed on the detection platform is provided with a light through hole so as to ensure the brightness of the shot image.

Optionally, as shown in fig. 2, the imaging device 250 includes a lens group 251 and a camera 252, and is used to capture cells in a sample smeared on a slide, and obtain a cell image.

Referring to fig. 7, fig. 7 shows still another schematic structure of a cell image analysis system according to an embodiment of the present invention. As shown in fig. 7, the imaging apparatus 700 includes a camera 710 and a lens group 720, wherein the lens group 720 may include a first objective lens 720a, a second objective lens 720b, and a relay cylinder 720c, and optionally, the lens group 720 may further include an eyepiece (not shown). The first objective lens 720a may be, for example, a 10-fold objective lens, and the second objective lens 720b may be, for example, a 100-fold objective lens. The lens group 720 may further include a third objective lens 720d, which may be, for example, a 40-fold objective lens. The user may select an objective lens with any magnification to shoot the glass slide 731 to be detected, as shown in fig. 7, a glass slide loading device (not shown) loads the glass slide to be detected in the first glass slide box 730 onto a detection platform, a glass slide moving device 740 on the detection platform moves the glass slide 731 to be detected within the field of view of the objective lens and fixes the glass slide to be detected, and an imaging device shoots an image of a sample cell in the glass slide to be detected, so as to obtain a cell image.

Alternatively, the slide loading device 230 and the slide unloading device 260 may be separate devices.

Optionally, the slide unloading device 260 includes a mechanical transfer section that automatically places a tested slide into a slide output module and a slide output module that unloads the tested slide into a second slide cassette. The slide output module can buffer the tested slide.

In some embodiments, referring to fig. 8a, fig. 8a shows an example of a slide unloading device according to an embodiment of the invention. In fig. 8a, the slide unloading device 860 comprises a mechanical conveyor 861 and a slide output module 862, wherein the mechanical conveyor 861 may be implemented as a robot arm, for example, which unloads the tested slide to the slide output module 862, and the robot arm clamps the tested slide 863 on the slide output module 862, turns over after moving horizontally and/or vertically, and vertically places the tested slide in the second slide box.

In other embodiments, referring to fig. 8b, fig. 8b shows yet another example of a slide unloading device according to an embodiment of the invention. In fig. 8b, the slide unloading device 860 comprises a mechanical conveyor 861 and a slide input module 862, wherein the mechanical conveyor 861 can be implemented as a robot arm, for example, which unloads the tested slide to the slide output module 862, and the robot arm clamps the tested slide 863 on the slide output module 862, turns over after moving horizontally and/or vertically, and places the tested slide horizontally in the second slide box.

It should be appreciated that in the above embodiments, when the distance between the second slide cassette and the slide output module is relatively short (e.g., less than or equal to a predetermined value), the robot arm does not need to hold the slide for horizontal movement, and the robot arm may omit horizontal and/or vertical movement, and the held slide is directly flipped over and placed vertically or horizontally in the second slide cassette.

In some embodiments, the detection platform transfers the slide that has been placed thereon to the slide output module 862. Further, the detection platform may be used to transport the slide to the position of the slide output module 862 via a belt.

In some embodiments, referring to fig. 8c, fig. 8c shows yet another example of a slide unloading device according to an embodiment of the invention. In fig. 8c, the mechanical transfer section can also be implemented, for example, as a pushing device (not shown) that pushes the tested slide 863 on the slide input module 862 directly horizontally into the second slide cassette.

Optionally, the slide unloading device 260 may also include only a mechanical conveyor. In this way, slide unloading efficiency can be further improved and the volume of the cell image analysis system can be reduced.

In some embodiments, referring to fig. 9a, fig. 9a shows an example of a slide unloading device according to an embodiment of the invention. In fig. 9a, the slide unloading device 960 includes a mechanical transfer portion 961, where the mechanical transfer portion 961 may be implemented, for example, as a robot arm that clamps the tested slide 963 on the test platform, moves horizontally and/or vertically, and then turns over to vertically place the tested slide in the second slide cassette.

In other embodiments, referring to fig. 9b, fig. 9b shows yet another example of a slide unloading device according to an embodiment of the invention, a robot 961 clamps a tested slide 962 on a test platform, turns over after moving horizontally and/or vertically, and places a tested slide 963 horizontally in a second slide cassette.

It should be appreciated that in the above embodiments, when the distance between the second slide cassette and the slide output module is relatively short (e.g., less than or equal to a predetermined value), the robot arm does not need to hold the slide horizontally and/or vertically, and the robot arm may omit the horizontal and/or vertical movement to place the tested slide vertically or horizontally in the second slide cassette.

In some embodiments, referring to fig. 9c, fig. 9c shows yet another example of a slide unloading device according to an embodiment of the invention. In fig. 9c, the mechanical transfer portion 961 may also be implemented as a pushing device, for example, which pushes the slide 963 to be tested directly and horizontally from the tested slide on the test platform into the second slide box.

Fig. 10 a-10 d illustrate a manner of storing slides. Fig. 10a shows a vertically forward slide storage mode, fig. 10b shows a horizontally forward slide storage mode, fig. 10c shows a vertically sideways slide storage mode, and fig. 10d shows a horizontally forward sideways slide storage mode, but none of these modes is visually clear of the slide labels. It is therefore very difficult to find a desired slide from a slide storage container in which the slide is stored for a long period of time. In order to reduce the storage space occupied by the slide, the interval between the slide and the slide is small, so that the slide is not easy to take by a finger, or a plurality of slide can be taken out at the same time each time, and the target slide is selected from the plurality of slide, thereby bringing increased inconvenience to users. According to the embodiment of the invention, the second glass slide box is used as a long-term storage container, so that a user can conveniently find a sample and can conveniently store and manage the sample.

Optionally, the second cassette 270 includes a plurality of adjacent receiving spaces that are arranged in a single row or a plurality of rows.

Referring to fig. 11 a-11 b, fig. 11a and 11b illustrate examples of a second slide cassette arranged in a single row according to an embodiment of the invention. Referring to fig. 12a and 12b, fig. 12a and 12b illustrate an example of a second slide cassette arranged in a double row according to an embodiment of the invention. Referring to fig. 13, fig. 13 illustrates an example of a second slide cassette arranged in three rows according to an embodiment of the invention.

The second slide box has smaller interval between slides, and only needs to meet the condition that samples (blood films) on the slides are not scratched, so that the unit space is ensured to contain as many slides as possible. The capacity of the second slide box can be configured by a user according to the needs so as to meet the needs of various different occasions in practical application. For example, different hospitals or users have different needs, and the users can configure the capacity of the second slide box to meet the capacity required for half a day, even a week, or other preset time period according to the different needs.

In some embodiments, the capacity of the second slide cassette is at least 5 times the capacity of the first slide cassette. For example, when a first cassette is configured to hold 10 slides to be tested, a second cassette is configured to hold at least 50 slides that have been tested. Further, the second glass slide box can comprise 50 adjacent accommodating spaces arranged and arranged, and can also comprise 50 adjacent accommodating spaces arranged in double rows, wherein each row can comprise 25 accommodating spaces.

In some embodiments, the second cassette is configured to hold at least 40, 60, 80, or 100 slides. For example, a single row of second slide cassettes may be configured to hold 60 slides, or a double row of second slide cassettes may be configured to hold 60 slides (30 slides per row).

Optionally, a hand-held device for holding is arranged on the second glass slide box. The handheld device can be realized as a handle arranged on the outer wall of one side of the second slide box, so that the second slide box is easy to hold and transfer, and a user can conveniently take and put the slide.

Optionally, an oil storage device is arranged in the second slide box and is used for collecting the oil of the tested slide in the second slide box. The oil storage device can be arranged at the bottom of the second glass slide box, so that the phenomenon that residual mirror oil on the glass slide obstructs the taking and placing of the glass slide is prevented.

Optionally, the first slide box and the second slide box are respectively disposed at two sides of the imaging device or the detection platform.

Optionally, an elastic device is disposed in the second slide box, and the elastic device is used for fixing the tested slide placed in the second slide box. Wherein the elastic means can clamp the slide in the accommodation space, and the slide is not detached from the accommodation space even if the second cassette is tipped or inverted.

Optionally, the second slide cassette 270 includes:

The control device controls the slide unloading device to move the tested slide into the corresponding preset area of the second slide box according to a preset rule.

The user may set the capacity, the position, the number (the number of preset areas) of the preset areas, and the like as needed.

In some embodiments, the predetermined region may be set according to sample attributes including sample information, pathology information (e.g., type of disorder), patient characteristics, test time, or sample collection source (e.g., department from which the sample was collected).

In some embodiments, the preset rules include moving the tested slide to a preset area corresponding to a sample property of the tested slide.

Referring to fig. 14a and 14b, fig. 14a and 14b illustrate examples of preset areas of a second slide cassette according to an embodiment of the present invention. In some embodiments, the user may set preset areas in the second slide box according to the sample collection source in the slide, such as a department, etc., as shown in fig. 14a, and fig. 14a includes 4 preset areas, namely, an area a, an area B, an area C, and an area D, corresponding to the department a, the department B, the department C, and other departments, respectively. Therefore, when a user searches the slide in future, the slide in the region B can be searched only according to the searched information, for example, the acquisition source is the department B, so that the slide searching efficiency is greatly improved. Similarly, in some embodiments, as shown in FIG. 14B, 3 preset zones are included in FIG. 14B, zone A, zone B, zone C, and the capacity in zone A is the sum of the capacities of zone B and zone C. It should be appreciated that the user may also set different preset regions according to other sample attributes, which is not limited herein.

It should be noted that, the above embodiment is only illustrative, and is not intended to limit the arrangement of the second glass sheet boxes in two rows, and the second glass sheet boxes can be divided into a plurality of preset areas according to the need whether they are arranged in a single row or in multiple rows.

In some embodiments, the preset rules further include determining a direction of the tested slide when placed in the second slide cassette based on the direction of the second slide cassette and/or placing the tested slide in the second slide cassette at a preset number of intervals.

When the second slide box is inserted into the tested slide, the label areas of the tested slide can be blocked, so that the slide can be conveniently searched and taken. Therefore, the user can insert at intervals according to the use requirement, the slide intervals are pulled apart, the label information of the slides is conveniently checked, and the slide interval placing mode enables the user to easily take out the slides without other slides. Referring again to the slide placement direction shown in fig. 10 a-10 d, when the control device controls the slide unloading device to unload the measured slide into the second slide cassette, the direction of the second slide cassette may be determined first, and then the control device controls the slide unloading device to unload the measured slide into the second slide cassette according to the slide placement direction of the second slide cassette.

Referring to fig. 15 a-15 c, fig. 15 a-15 c illustrate examples of slides that are spaced apart according to embodiments of the present invention. In fig. 15a, the slides in the second slide cassette are placed adjacent to each other without a gap, in fig. 15b, the slides in the second slide cassette are placed one slide apart, and in fig. 15c, the slides in the second slide cassette are placed two slides apart. It should be appreciated that the amount of separation between slides in the second cassette can be set by the user as desired and is not limited in this regard.

That is, the user can set at least one of the capacity, arrangement, setting of the preset area, and slide placement (including the direction and/or the interval between slides) of the second slide cassette, providing great flexibility for slide storage, being able to meet the needs of the user in various different situations, and improving storage efficiency.

Optionally, the second slide box comprises a marking part, and the marking part comprises an artificial tag and/or an electronic tag, and the artificial tag and/or the electronic tag is used for recording the characteristic information of the second slide box.

When the second slide box is directly used as a container for storing slides for a long time, in order to facilitate the later quick searching of samples, the information of the slide box can be marked on the second slide box, and each detected slide stored in the slide box can be marked.

In some embodiments, each receptacle on the second cassette can be provided with a corresponding identifier (e.g., a number for each row and/or column) to indicate the location of the receptacle, which can help to quickly locate the stored slides.

In some embodiments, a manual tab is included on the second slide cassette. Wherein the user can manually write information of the second slide box at the manual label, such as a number (ID information), a name, a detection department, a detection time or a detection person, etc.

In some embodiments, the second slide cassette includes an electronic tag thereon. The user can store and write information of the second slide box, such as a number (ID information), a name, a detection department, detection time or detection personnel, and the like, in the electronic tag, and can record related information of the detected slide by editing the electronic tag (such as an electronic chip and RFID), so that quick searching and positioning of a subsequent sample are facilitated.

In some embodiments, the electronic tag is further configured to record index information, storage location information, feature information of a sample, and/or a detection result of the sample for each of the tested slides in the second slide box.

Specifically, when a user needs to search a certain stored detected slide, the number of the second slide box where the detected slide is located and the position of the detected slide in the slide box can be obtained by searching in a corresponding storage system according to the known index information of the detected slide, such as the ID information of the detected slide, and the like, so that the detected slide to be searched can be quickly positioned, and the management and the search of the slide by the user are greatly facilitated.

In some embodiments, the electronic tag may include a read-write RFID chip or other electronics to record or alter the ID information of the second slide cassette, upon which the user locates and looks up the held slide specimen.

In some embodiments, information in the electronic label can be de-duplicated and rewritten to record characteristics and/or index information of the held slide within the cassette.

Optionally, the system further comprises:

And the storage device is used for storing the characteristic information of the second slide box and/or the index information, the storage position information, the characteristic information of the sample and/or the detection result of the sample of each tested slide in the second slide box.

The storage device may include a database system, configured to store ID information of the second slide boxes and corresponding position information thereof, and index information, storage position information, feature information of samples, and/or detection results of the samples in each second slide box. The storage device may further include retrieval software that can retrieve a slide to be searched for by the stored ID information of the second slide cassette or index information of the slide, feature information of the sample, or the like.

In some embodiments, after the glass slide is shot on the detection platform, the imaging device obtains a cell image of the glass slide, the control device determines a specific storage position of the glass slide in a preset area according to the sample attribute of the glass slide, and the control device controls the glass slide unloading device to unload the glass slide to the specific storage position, and simultaneously, the ID information of the glass slide, the cell image, the specific storage position stored in the second glass slide box and the ID information of the second glass slide box can be stored in the storage device in an associated mode. Further, all relevant information of the slide glass before detection can be stored in association with the cell image, the position information stored in the second slide box and the ID information of the second slide box according to the ID information of the slide glass.

In some embodiments, when a user needs to find the detected slide P (i.e., knows at least one index information S of the detected slide P), the information S may be retrieved in the database system, and then the position L of the detected slide P stored in the second slide case Q may be obtained, the user may quickly locate the second slide case Q by using a manual tag on the second slide case Q, so as to find the detected slide P, and after the user may quickly locate the second slide case Q by using a manual tag on the second slide case Q, a handheld reading device may be used to determine whether the specific position of the detected slide P is L by reading the information of the loaded slide recorded in the electronic tag in the second slide case Q, and then find the detected slide P according to the specific position. It is understood that the user can set up manual label and electronic tags simultaneously, combines the advantage that manual label is directly perceived easily to seek and electronic tags stores the sample information of each slide, improves slide's storage, management and inquiry efficiency.

Optionally, the system has a counting component for counting the number of slides tested in the second slide cassette.

In some embodiments, the number of slides in the second cassette may be counted as the number of slides that have been tested in the second cassette by counting the number of ID information of slides in the storage device that are associated with the second cassette.

In some embodiments, the number of times the slide unloading device is actuated may be counted as the number of slides that have been tested in the second slide cassette.

In some embodiments, the number of receiving spaces in which slides are placed may be counted as the number of slides that have been tested in the second slide cassette by detecting whether each receiving space has a slide placed. Further, the accommodation space position information or ID information where the slide is placed may also be counted to indicate the accommodation space where the slide is placed and the accommodation space where the slide is not placed.

Optionally, the system further comprises a prompting device for prompting a user to replace the second slide box when the number of the tested slides in at least one preset area reaches a preset threshold.

In some embodiments, when the counting component counts that the number of accommodating spaces in which the glass slides are placed in a certain preset area reaches the number of accommodating spaces in the preset area, that is, the preset area is already full, the user may be prompted to replace the second glass slide box. Or in order to store the measured slide by using the second slide box to the maximum extent, the user can not be reminded temporarily when the preset area is full, because other preset areas can be placed continuously at the moment, if the next measured slide belongs to the other preset areas, the next measured slide can be placed continuously in the other preset areas, but if the next measured slide still belongs to the full preset area, the user can be reminded to replace the second slide box at the moment.

In some embodiments, the prompting device may employ a voice prompt, and/or employ an indicator light prompt, without limitation.

Optionally, the system further comprises detecting means for detecting whether the second cassette is placed in a predetermined position before the tested slide is loaded into the second cassette.

In some embodiments, the detection device includes a sensor that can detect whether the second cassette is placed in a predetermined position.

Optionally, the prompting device is further configured to prompt a user that the second slide box is not placed when the detection device detects that the second slide box is not placed at the predetermined position.

In some embodiments, when the cellular image analysis system is started, or when or before a slide needs to be unloaded to the second slide box, if the second slide box is detected to be not placed at the predetermined position, the prompting device may use a voice prompt, for example, voice play "the second slide box is not placed", or may use an indicator light to prompt, for example, the indicator light is on or blinks, to indicate that the second slide box is not placed, and may use voice and the indicator light to prompt simultaneously, which is not limited herein.

Optionally, the system further has a display means for displaying the position in the second slide cassette where the slides have been loaded and/or the number of slides in the second slide cassette.

In some embodiments, the display component may be a display screen. Wherein, the distribution image of the second slide box can be displayed in the display screen, and different colors are adopted to distinguish the part loaded with the tested slide from the part not loaded with the slide. Further, the position information corresponding to every other accommodation space may also be displayed at the same time. Referring to fig. 16, fig. 16 illustrates an example in which a second slide cassette is displayed in a display part according to an embodiment of the present invention. In fig. 16, the second slide cassette may be divided into a preset area a, a preset area B, and a preset area C, and may be a first color (e.g., green, not shown) and/or a first symbol (e.g., o or v) may indicate that the receiving space has been loaded with slides, and a second color (e.g., yellow, not shown) and/or a second symbol (e.g., Δor x, or no mark) may indicate that the receiving space has not been loaded with slides, whereby the 1 st row, 1 st column, and 2 nd row, 1 st column in the preset area a in the second slide cassette are loaded with slides, and the 1 st row, 2 nd column, and 3 rd row, 2 column in the preset area B are loaded with slides. Further, the number of slides loaded in the second cassette may be displayed, such as 5/capacity 20 of the stored slides, and the number of slides loaded in each preset area in the second cassette may be displayed, such as preset area A, 2/capacity 6 of the stored slides, preset area B, 3/capacity 6 of the stored slides, preset area C, and 0/capacity 8 of the stored slides.

Optionally, the system further comprises an identification device 280 for identifying an electronic identification mark in the slide to be tested or the tested slide to obtain the identity information of the slide to be tested or the tested slide.

In some embodiments, the electronic identification of the slide under test or the tested slide may include, but is not limited to, a barcode and/or a radio frequency identification tag of the slide under test or the tested slide.

In some embodiments, the identification information of the test slide or the tested slide may include, but is not limited to, a number (ID) of the test slide or the tested slide, and/or a source of the test slide or the tested slide (e.g., from which department, and/or from which patient, etc.).

Specifically, the detection or analysis of the sample in the slide to be detected may be based on the bar code or the radio frequency identification tag on the slide to be detected to obtain the relevant information of the sample, such as the information of the patient, the operation information of the slide to be detected, and so on. In some embodiments, the relevant information of the sample includes, but is not limited to, personal information of the patient, barcode information of the sample. The personal information of the patient may include, among other things, name, patient number, height, weight, etc.

According to an embodiment of the present invention, a cell image analysis system includes:

A control device;

Optionally, the recycling slide box is set into a plurality of preset areas according to sample attributes, and the control device controls the slide unloading device to move the tested slide into the preset areas corresponding to the sample attributes of the tested slide, wherein the sample attributes comprise sample information, pathological information, patient characteristics, detection time or sample acquisition sources.

Optionally, the control device controls the slide unloading device to place the tested slides in the recovery slide box at intervals of a preset number.

Optionally, an elastic device is disposed in the recovery slide box, and the elastic device is used for fixing the tested slide placed in the recovery slide box.

Optionally, the recycling slide box comprises an identification part, wherein the identification part comprises an artificial tag and/or an electronic tag, the artificial tag and/or the electronic tag is used for recording characteristic information of the recycling slide box, and the electronic tag is also used for recording index information, storage position information and sample characteristic information of each tested slide in the recycling slide box and/or a sample detection result.

Optionally, the system further comprises:

And the storage device is used for storing the characteristic information of the recycling glass slide box and/or the index information, the storage position information and the characteristic information of the sample and/or the detection result of the sample of each tested glass slide in the recycling glass slide box.

Optionally, the system further comprises:

a counting part for counting the number of the detected slides in the recovery slide box;

And a display part for displaying the position of the detected slide in the recovery slide box and/or the number of the detected slides in the recovery slide box.

Optionally, the system further comprises a prompting device for prompting a user to replace the recovery slide box when the number of the tested slides in at least one preset area reaches a preset threshold.

Optionally, the system further comprises a detection device for detecting whether the recovery slide box is placed at a predetermined position before the detected slide is loaded into the recovery slide box, and when the detection device detects that the recovery slide box is not placed at the predetermined position, the prompting device prompts a user that the recovery slide box is not placed.

It should be understood that the components included in the cellular image analysis system shown above are illustrative only and may include more or fewer components. The invention is not limited in this regard.

Fig. 17-19 illustrate perspective views of a second cassette or recovery cassette 270 provided in accordance with an embodiment of the present invention.

As illustrated in fig. 17 and 18, the recovery slide cassette 270 has a housing 12 and a plurality of slots 114 provided in the housing 12 for receiving slides 10. In the current embodiment, the recovery slide cassette 270 has 60 slots or recovery storage slots 114 that can recover and store 60 slides 10.

The housing 12 includes four sides (i.e., left and right opposite sides and front and rear opposite sides), a top and a bottom. The case 12 has a first side plate 1110 and a second side plate 1120 on two opposing first side portions 1210 (left and right side portions in fig. 17 and 18), respectively. Each slot 114 is formed by a first support 1141 on the first side panel 1110 and a second support 1142 on the second side panel 1120 opposite the first support 1141.

The first side panel 1110 and the second side panel 1120 are, for example, releasably mounted to the inside of the respective first side 1210 of the housing 12. Of course, in other embodiments, the first side panel 1110 and the second side panel 1120 may be integrated inside the corresponding first side 1210 of the housing 12, for example.

The housing 12 has openings for the slide 10 to enter and exit the slot 114, i.e., a first opening 1220 and a second opening (not shown), on opposite second sides (front and rear sides), respectively, whereby the second cassette or the recovery cassette 270 communicates front and rear, and the recovered slide 10 can be inserted or removed from front to rear, or from rear to front. By providing openings on both the front and rear sides of the recovery slide box 270, a user can conveniently find and clean the slide.

In a preferred embodiment, the length of each recovery storage slot 114 is less than the length of the slide. It is particularly preferred that the length of each recovery storage slot 114 is less than the length of the slide by the length of the slide's label zone (i.e., slide label information printing zone) so as to ensure that the slide label information printing zone is not covered by the slot and that the slide label information printing zone is not contaminated by the lens oil that is dropped onto the slide, thereby avoiding contamination of the user's hands when looking for slides.

In addition, a handle 121 is provided on the top 1230 of the housing 12 for the convenience of the user to access and replace the recovery slide cassette 270.

Further, as shown in fig. 17 to 19, anti-slip recesses 122 are provided on both the left and right outer sides of the housing 12 (i.e., the outer sides of the first side 1210 where the side plates are located) for a user to take in and take out the slide cassettes 270 from the lateral direction.

At the time of recovering a slide, the recovery slide cassette 270 is accommodated in an accommodating seat 3 provided in the cell image analysis system, as shown in fig. 20. As shown in fig. 19 and 20, in order to facilitate placement of the recovery glass box 270 in the housing seat 3, the recovery glass box 270 has a fool-proof design, and on the outside (here, the left outside) of one of the first side portions 1210 of the housing 12, there is a guide groove 123 functioning as a fool-proof function, which cooperates with the guide bar 38 provided in the housing seat 3 to guide the recovery glass box 270 into the housing seat 3. Further, recesses 124 are provided on both sides of the guide groove 123, respectively, which cooperate with the ball plungers 37 provided in the housing seats to fixedly position the recovery glass box 270 in the housing seat 3. Thereby, the recovery glass sheet cassette 270 can be accurately positioned in the accommodation seat 3, and misoperation of a user can be prevented.

Further, as shown in fig. 19 and 20, a fixing device 125 is provided at the bottom of the recovery glass box 270, the fixing device 125 is used in cooperation with a suction device 32 provided in the bottom of the accommodating cavity of the accommodating seat 3, and when the suction device 32 cooperates with the fixing device 125, the recovery glass box 270 is firmly fixed on the accommodating seat 3, and at this time, the user cannot take out the recovery glass box 270 from the accommodating seat 3.

In addition, in the embodiment shown in fig. 20, the housing seat 3 further includes an identification portion 33 for detecting whether the recovery glass sheet cassette 270 is put into the housing seat 3.

Lens oil is often remained on the analyzed slide, a large amount of oil stains are remained in the recovered slide box after the recovered slide box is reused for a period of time, so that the pollution of the oil stains is caused, and meanwhile, a user needs to frequently replace gloves, so that the cost is increased. Therefore, the embodiment of the invention provides a novel oil guiding and gathering system.

In the oil guiding and collecting system according to an embodiment of the present invention, at least one oil guiding groove 112 is formed in at least one of the first side plate 1110 and the second side plate 1120 of the housing. As shown in fig. 21, fig. 21 shows a perspective view of a first side plate 1110 according to an embodiment of the present invention, in which an oil guide groove 112 is formed in the first side plate 1110.

Preferably, at least one oil guide groove 112 is formed in each of the first side plate 1110 and the second side plate 1120. It is further preferred that the oil guide grooves formed in the first side plate 1110 are asymmetrically arranged with the oil guide grooves formed in the second side plate 1120 to ensure smooth recovery of the slide into the slot 114.

Preferably, as shown in fig. 21, all of the slots 114 are penetrated by the oil guide groove 112 from top to bottom, so that the mirror oil in the slots 114 is guided along the oil guide groove 112, in particular to the bottom 1240 of the housing 12. That is, the at least one oil guide groove 112 is configured to penetrate a support portion of each of the slots 114 on a side plate where the at least one oil guide groove is located, for example, from the middle. For example, in the embodiment shown in fig. 21, the oil guide groove 112 opened in the first side plate 1110 penetrates the first support portion 1141 of each of the slots 114. In the case that the second side plate 1120 is provided with an oil guiding groove, the oil guiding groove of the second side plate 1120 may penetrate the second supporting portion 1142 of each slot 114.

As shown in fig. 21, the oil guide groove 112 extends at least from an uppermost one 114' of the plurality of slots, for example, vertically to near the bottom 1240 of the housing 12, and penetrates the first support portion 1141 of each slot 114. Preferably, the oil guide groove 112 extends obliquely (i.e., at an angle to the vertical) at least from the uppermost slot 114' of the plurality of slots to near the bottom 1240 of the housing 12, thereby enabling the slide to be smoothly retrieved into the recovery slide cassette 270 without jamming in the slot 114.

In some embodiments, at least one first oil guide groove 111 is formed in at least one of the first side plate 1110 and the second side plate 1120, at least one second oil guide groove 112 is formed in at least one of the first side plate 1110 and the second side plate 1120, the at least one first oil guide groove 111 extends near a side edge of the side plate where it is located and does not extend through the support portion of each slot, and the at least one second oil guide groove 112 extends through the support portion of each slot in the side plate where it is located.

In the embodiment shown in fig. 21, a first oil guide groove 111 and a second oil guide groove 112 are formed in the first side plate 1110. The first oil guide groove 111 extends near the front side edge of the first side plate 1110 in front of the insertion groove 114, from the underside of the top 1230 of the housing 12 to near the bottom 1240 of the housing 12, in particular to the oil reservoir 127 provided in the bottom 1240 of the housing 12, the oil reservoir 127 being able to receive oil dirt guided by the oil guide grooves 111, 113 of the side plates for easy cleaning by a user. The second oil guide groove 112 extends from the uppermost insertion groove 114' up to near the bottom 1240 of the housing 12, particularly to the oil reservoir 127, and penetrates the first support portion 1141 of each insertion groove 114.

Although fig. 21 shows only the oil guiding structure of the first side plate 1110, it is understood that the second side plate 1120 may have the same or similar oil guiding structure.

Furthermore, as shown in fig. 21, the first side plate 1110 has a clamping portion 113, particularly an elastic clamping portion (e.g., a spring piece), for clamping the slide from the side in the slot 114, respectively, for each slot 114, and the slide from the side can protect the blood film smeared on the upper side of the slide. It will be appreciated that the second side plate 1120 also has, for each slot 114, a clamping portion 113 for clamping the slide laterally in the slot 114, respectively, corresponding to the first side plate 1110.

Preferably, the clamping portions 113 extend obliquely from the respective side plate towards the longitudinal axis of the slot 114. The angled design of the lateral gripping portion, particularly the large angle design, can provide assistance in cleaning slides in the recovery cassette 270, facilitating cleaning of the slides by the user. That is, the angled design of the lateral gripping portion not only effectively provides lateral gripping forces, but also provides front-to-back assistance when cleaning slides in the recovery cassette 270 from front to back, making cleaning slides smoother. In addition, when the user takes out the recovery cassette after completion of recovery from the housing seat, the slide inside will not fall out even if the recovery cassette is turned upside down and tilted.

Fig. 22 shows a preferred design of the spring clips 113, each spring clip 113 extending obliquely from the respective side plate towards the longitudinal axis of the respective slot 114, at an angle of approximately 40 °.

Further, as shown in fig. 18, to facilitate the user's searching for the recovered slide, a label 128 is provided on the handle 121 for the user to distinguish between different recovery cassettes 270. Further, on the right side of the housing 12, there is an information storage identifying section 126 in which the case of the slide collected in the collection cassette 270 is stored. Accordingly, as shown in fig. 20, an information identification module 36 (e.g., RFID card reader) is provided on the side plate 31 of the housing seat 3, and the information identification module 36 is used in cooperation with the information storage identification portion 126.

Therefore, the embodiment of the invention provides a high-capacity slide recovery box capable of preventing oil, guiding oil, collecting oil and cleaning slide rapidly. Aiming at the defects of small capacity, inconvenient cleaning of slides, residual greasy dirt and the like of the existing slide recovery box, the embodiment of the invention greatly enhances the usability of the slide recovery box through the characteristics of an oil guide groove structure, a double-opening (slide can be in and out in a two-way) structure, a two-side large-bevel-angle compaction slide structure and the like.

Fig. 23 shows a perspective view of a second cassette or recovery cassette 300 according to another embodiment of the invention, the recovery cassette 300 comprising a cassette body 310 and a slot assembly 320 disposed in the cassette body 310. The case 310 has a receiving cavity 311. One side surface of the accommodating chamber 311 is provided with an insertion opening 312 for laterally inserting a sample slide, and the other side surfaces and the bottom surface of the accommodating chamber 311 are closed. The slot assembly 320 is disposed in the receiving cavity 311, and the slot assembly 320 has at least one row of slot sets having at least two slots 321 for inserting the sample slide 800. All the slots 321 in each row of slot groups are transversely arranged and are stacked in the vertical direction, and the inlets of the slots 321 are communicated with the inserting and taking ports 312.

The mirror oil is generally located at the middle of the specimen slide 800, and when the specimen slide 800, which has been completed to be inspected, is moved to the recovery slide cassette 300, it is inserted into the corresponding slot 321 from the insertion opening 312, and the middle is accommodated in the slot 321. Since the other side and bottom surfaces of the case 310 are closed except for the insertion opening 312. Therefore, most of the liquid on the sample slide 800 flows into the accommodating cavity of the box body 310 even if flowing everywhere, so that the outflow situation of the liquid can be reduced, the pollution to other devices and instruments can be avoided, and the inconvenience to operators can be reduced.

Referring to fig. 23 to 25, in one embodiment, the case 310 has a bottom case 314, a top case 315, and a side case 313 connected between the bottom case 314 and the top case 315. The bottom shell 314, the top shell 315 and the side housing 313 enclose a receiving cavity 311, and the insertion opening 312 is located on one surface of the side housing 313. The entire box 310 may be generally square with three of the four sides of the box 310 being closed and only one side being provided with the access opening 312.

Referring to fig. 26, the receiving cavity 311 has an outer side and an inner side opposite to the outer side. To further reduce outflow of fluids such as mirror oil, in one embodiment, the slot assembly 320 has a limiting structure that forms a slide insertion channel in the slot 321 that is disposed diagonally downward from the outside to the inside so that the sample slide 800 is disposed diagonally downward from the outside to the inside in the slot 321. As shown in fig. 5, the specimen slide 800 is inserted into the slot 321 from right to left. The left side of the drawing sheet is the front end 801 of the specimen slide 800, and the front end 801 is located inside the accommodating chamber 311. The right side of the drawing is the rear end 802 of the specimen slide 800, and the rear end 802 is located outside the accommodating chamber 311. At this time, that is, the front end 801 of the sample slide 800 is lower than the rear end 802 thereof, the liquid such as the mirror oil is guided to flow in the direction of the front end 801 thereof, and the liquid is further guided to flow into the inside of the accommodating chamber 311 of the cassette 310, not to the side of the insertion port 312 of the accommodating chamber 311, and the outflow of the liquid to the outside of the recovery slide cassette 300 is further reduced.

The slide insertion channel refers to a movable space of the sample slide 800 in the cassette 310 after the sample slide 800 is stored in the cassette 310, that is, the sample slide 800 can only move in the slide insertion channel. The cassette 310 has a slot 321 and the slide insertion channel may include all or a portion of the slot 321, such as a slide insertion channel that receives the sample slide 800 formed by a portion of the slot 321 and other components (e.g., a lower or upper punch as described below).

In one embodiment, the restraint structure includes a hold down 322, the hold down 322 having a hold down 3221 for holding down the sample slide 800, the hold down 3221 for holding down one end of the sample slide 800 from above the sample slide 800 such that the sample slide 800 is disposed obliquely downward from outside to inside in the slot 321. Typically, the hold down 322 is primarily pressed down against the front end 801 of the specimen slide 800, although in some embodiments, the hold down 322 may be pressed against other locations on the specimen slide 800, as long as the front end 801 of the specimen slide 800 is below the rear end 802 thereof.

The hold-down 322 may be disposed within the slot 321 or may be disposed outside the slot 321. Referring to fig. 5, in one embodiment, an inlet is formed at an end of the slot 321 facing the insertion opening 312, an outlet is formed at an end of the slot 321 facing away from the inlet, and the inlet and the outlet are disposed through. The front end 801 of the specimen slide 800 protrudes beyond the outlet. The pressing portion 3221 is located outside the outlet, and is used to press down a portion of the sample slide 800 that protrudes outside the outlet, i.e., against the front end 801 of the sample slide 800. In this embodiment, the specimen slide 800 can move only in a portion of the space in the slot 321 due to the restriction of the hold-down piece 322, which is one of the components of the slide insertion channel, and the passage space defined by the hold-down piece 322.

In this embodiment, the pressing portion 3221 is lower than the upper groove wall 323 of the corresponding slot 321 and higher than the lower groove wall 324, and finally, a space for the sample slide 800 to be disposed obliquely downward is limited in the slot 321.

Referring to fig. 26, in an embodiment, the pressing member 322 is disposed obliquely, wherein an end of the pressing member 322 facing the insertion opening 312 is a first end 3222, an end of the pressing member 322 facing away from the insertion opening 312 is a second end 3223, and the pressing portion 3221 is located at the second end 3223 of the pressing member 322. The first end 3222 of the hold-down piece 322 is higher than the second end 3223 thereof, such that when the sample slide 800 is inserted, the hold-down piece 322 forms a guide opening that tapers from right to left toward the first end 3222 of the sample slide 800, facilitating insertion of the sample slide 800 below the corresponding hold-down piece 322, and guiding movement of the sample slide 800 toward the second end 3223 of the hold-down piece 322.

Of course, the hold down 322 described above is just one of the means for achieving an angled setting of the specimen slide 800. In another embodiment, the restraint structure includes an upper top (not shown) for lifting one end of the specimen slide 800 from below the specimen slide 800 such that the specimen slide 800 is disposed diagonally downward from the outside to the inside in the slot 321.

The upper top member generally lifts the rear end 802 of the specimen slide 800, although in some embodiments the upper top member may be positioned elsewhere on the specimen slide 800, so long as the front end 801 of the specimen slide 800 is positioned below the rear end 802 thereof.

The upper top piece has an upper top for jacking up the specimen slide 800. Similar to the hold down 322, the upper top piece may be disposed within the slot 321 or may be disposed outside of the slot 321. In one embodiment, the upper top is located outside of the slot 321, which is used to jack up the portion of the specimen slide 800 located outside of the slot 321, i.e., the rear end 802 of the specimen slide 800.

The lower press 322 and the upper top may be mounted to the socket assembly 320 or the case 310. The lower press 322 and the upper press may be used alternatively or in combination. The upper and lower pressing pieces 322 may be provided in the slot 321, may be provided outside the slot 321, or may be provided one inside the slot 321 and the other outside the slot 321.

In one embodiment, the upper and lower press pieces 322 are partially or entirely made of an elastic material, so that the upper and lower press pieces 322 have certain self-adaptive adjustment characteristics when contacting the sample slide 800, and avoid hard contact with the sample slide 800. Of course, in other embodiments, the upper and lower press pieces 322 may be made of non-elastic materials.

Furthermore, in another embodiment, the slot 321 includes an upper slot wall 323 and a lower slot wall 324, wherein at least the lower slot wall 324 is disposed obliquely downward from the outside to the inside to form a limiting structure. After the sample slide 800 is inserted into the slot 321, it is placed along the inclined surface of the lower slot wall 324 under the force of gravity so that the front end 801 of the sample slide 800 is lower than the rear end 802 thereof.

In this embodiment, the upper groove wall 323 may be an inclined surface in the same direction as the lower groove wall 324, but of course, it may be disposed horizontally, or may even be an inclined surface opposite to the lower groove wall 324 (opposite to the inclined direction), and the shape of the upper groove wall 323 is not limited herein.

In addition to the various structures described above, the confining structure may be of other types to allow the sample slide 800 to be disposed obliquely and direct the liquid thereon toward the front end 801 thereof.

Further, referring to fig. 26 and 27, in one embodiment, the slots 321 include an upper slot wall 323 and a lower slot wall 324, and the middle portions of the upper slot wall 323 and the lower slot wall 324 of all the slots 321 in the same column are left empty, so as to connect all the slots 321 in the same column, and the limiting structure is located at the empty space 325. The gap 325 can facilitate the setting of the limiting structure, and is also convenient for the liquid such as the mirror oil to flow to the bottom wall of the accommodating cavity 311, avoiding more residues on the upper groove wall 323 and the lower groove wall 324, and simultaneously being convenient for observing the condition of the sample slide 800 in the slot 321.

On the other hand, in order to further reduce the outflow of the liquid such as the mirror oil out of the cassette 310, referring to fig. 6, in one embodiment, the accommodating cavity 311 has a liquid storage tank 317 therein, and the liquid storage tank 317 is used for collecting the liquid flowing down from the sample slide 800, so as to further reduce the outflow of the liquid out of the recycling slide cassette 300.

In one embodiment, the reservoir 317 is disposed on the bottom wall of the receiving chamber 311, and the liquid collected from various locations within the receiving chamber 311 eventually flows to the bottom wall of the receiving chamber 311 and is temporarily stored in the reservoir 317.

In one embodiment, at least one liquid storage groove 317 is disposed below each row of the slot sets. The reservoir 317 may be inverted T-shaped with the vertical section 3171 of the inverted T-shaped reservoir 317 extending below the corresponding set of slots and the lateral section 3172 of the inverted T-shaped reservoir 317 being located outside the set of slots. When the slot sets are more than two, the lateral segments 3172 of the reservoirs 317 of adjacent slot sets are in communication with each other so that liquid from all slot sets can be pooled at the lateral segments 3172 for subsequent treatment of the liquid.

In fig. 27, the liquid reservoir 317 is concavely provided on the bottom wall of the accommodation chamber 311. In other embodiments, the bottom wall may be inclined to form the liquid storage groove 317, for example, an end of the bottom wall on the inner side may be inclined to form the liquid storage groove 317 with the side surface of the case 310 on the inner side of the accommodating chamber 311.

Further, the number of the slot sets may be flexibly set according to the recycling requirement and the space requirement, as shown in fig. 1, and in one embodiment, the slot sets are one set. As shown in fig. 22 to 23, in one embodiment, the slot assembly 320 has at least two rows of slot sets, all of which are disposed side by side in the receiving cavity 311 of the case 310.

Further, whether one set or more than two sets of slots are employed. In one embodiment, the outer wall of the box 310 has a readable unit 331 representing the identity information of the recovered slide box 300, and the readable unit 331 is a series of components capable of transmitting the identity information, such as a radio frequency identification tag, a two-dimensional code, a bar code, and the like. The identity information may be unique. The identity of the current recovery slide cassette 300 can be recorded by the identification of the readable unit 331, and which sample slides 800 are placed in the recovery slide cassette 300, so that when a certain sample slide 800 needs to be queried later, it can be determined which recovery slide cassette 300 is in accordance with the recorded information.

Of course, to more precisely determine the position of the sample slide 800, in one embodiment, the cassette 310 or the slot assembly 320 is provided with index information 322 for displaying the serial number of the slot 321. As shown in fig. 6, the index information 322 is provided on the socket component 320. The guiding information 322 may be digital or other information, so long as the sequence of each slot 321 can be displayed. The guide information 322 may be provided for each slot 321 individually or may be provided with a certain number of slots 321.

There is also provided a slide storage method of a cellular image analysis system according to an embodiment of the present invention, referring to fig. 28, fig. 28 shows a schematic flowchart of a slide storage method of a cellular image analysis system according to an embodiment of the present invention. As shown in fig. 28, the method 1700 includes:

Step S1710, sequentially obtaining slides to be tested from the first slide box and loading the slides to the detection platform;

step S1720, detecting a sample in the slide to be detected on the detection platform, wherein the detected slide to be detected is a detected slide;

Step S1730, unloading the detected slide from the detection platform to a corresponding region of a plurality of preset regions of a second slide box according to the sample attribute of the detected slide, wherein the plurality of preset regions are set by a user according to the sample attribute;

According to an embodiment of the present invention, in step S1730, unloading the tested slide from the test platform to a corresponding region of a plurality of preset regions of a second slide cassette according to sample properties of the tested slide, including:

Acquiring position information of corresponding areas of sample attributes of the tested slide in the preset areas;

And moving the detected slide to the corresponding region according to the position information, and placing the detected slide in the second slide box at intervals of a preset number.

According to the embodiment of the invention, when the detected slide is unloaded into the second slide box, the slide can be classified according to the information related to the sample in the slide and then placed in different preset areas, and the same type of slide can be placed in the same preset area, so that the slide is convenient to classify and store for a long time and is beneficial to searching of the sample.

Specifically, after the imaging device shoots the slide, the control device determines the preset area and the specific position where the slide is to be placed in the preset area according to the sample attribute of the slide, and controls the slide unloading device to move the slide to the second slide box according to the specific position, as described above, the interval between slides placed in the second slide box can be set by the user, at this time, the slide unloading device determines the placing direction of the slide based on the direction of the second slide box, and unloads the slide to the second slide box according to the placing interval set by the user.

Optionally, the second slide cassette is replaced and directly used as a storage container at intervals of a preset time period or when the number of the tested slides in at least one preset area in the second slide cassette reaches a preset threshold value.

If the capacity of the second slide box can meet the capacity of all detected slides within a period of time (such as one day), the user can select to replace the second slide box only in a preset time or a fixed time (such as the end of daily work), and directly move the second slide box into a special slide storage space for long-term storage, so that the process of frequently replacing the second slide box in the process of detecting a plurality of first slide boxes is omitted, the process of transferring the detected slides in the second slide box into a long-term storage container is also omitted, the work flow of the user is greatly saved, and the storage efficiency of the slides is improved.

Optionally, the second slide cassette has an electronic tag, the method further comprising:

And storing the characteristic information of the second slide box, the index information, the storage position information and the characteristic information of the sample and/or the detection result of the sample of each tested slide in the second slide box in the electronic tag.

Optionally, the method further comprises:

Reading the electronic tag of the second slide box to obtain index information of each tested slide;

Inquiring in the index information of each tested slide according to the index information of the slide to be checked to obtain the storage position information of the slide to be checked;

And taking the slide to be checked out of the second slide box according to the storage position information of the slide to be checked.

In some embodiments, a cell image analysis system according to an embodiment of the present invention illustrates the operation of its slide storage.

The user performs cellular image analysis on the slides to be tested in the different first slide boxes at different times, and it is assumed that the user detects a slides to be tested in the first slide boxes with the capacity of C1 in one day,

Firstly, a user starts a cell image analysis system, at the moment, whether the second slide box is at a preset position or not can be detected, if the second slide box is not at the preset position, the user is prompted, and if the second slide box is at the preset position, detection of each slide is started;

then, for each first glass sheet box, a user sends out a detection instruction through an operating system;

Then, after receiving the detection instruction, the control device controls a mechanical arm in the slide loading device to sequentially clamp the slide to be detected from a first slide box positioned at one side of the imaging device or the detection platform, and can load the slide to be detected directly (or indirectly through a slide input module) to the detection platform through at least one operation of horizontal movement, vertical movement and overturning;

Then, the imaging device positioned above the detection platform shoots cells in a specific area in the glass slide to be detected according to shooting conditions set by a user to obtain a cell image of the glass slide to be detected, and the shot glass slide to be detected is recorded as a detected glass slide;

Then, the control device determines which preset area in the second slide box the sample to be detected belongs to and which containing space is placed in, namely a specific storage position, according to the sample attribute of the slide to be detected;

Then, the control device controls a mechanical arm in the slide unloading device to directly unload (or indirectly unload through a slide output module) the detected slide on the detection platform to a specific storage position in a corresponding preset area in a second slide box with the capacity of C2 according to the specific storage position;

Then, the identity information of the detected slide, the photographed cell image, the detection time, the ID information of the second slide box, the specific position information of the detected slide in the second slide box and the like can be stored in a storage device in an associated mode, meanwhile, the number of the detected slides in the second slide box is added by 1 in a technical unit in the system, and in a second slide box schematic diagram displayed by a display component, a region corresponding to the detected slide is changed from a second sign into a first sign to indicate that the region is loaded with the detected slide;

Then, if the counting unit counts that the second slide box is full of the detected slide, the prompting device prompts the user to replace the second slide box, the user can hold a handle arranged on one side of the second slide box full of the detected slide, take the second slide box out of the cell image analysis system and directly put the second slide box into a special storage area for long-term storage of the detected slide, wherein if the capacity C2 of the second slide box is more than or equal to C1×a, namely, the second slide box can meet the number of detected slides in one day, and at the moment, whether the second slide box is full or not, the user can replace the second slide box after finishing detection in the same day and take the taken second slide box as a long-term storage container;

Then, when the user needs to re-detect one or more detected slides, the information related to the detected slide can be searched in index information in all second slide boxes in the database, namely, the ID information of the second slide box where the detected slide is located, the storage position of the second slide box and the storage position of the detected slide in the second slide box can be obtained, so that the detected slide can be directly and accurately found.

Embodiments of the present application also provide a computer readable storage medium storing a plurality of program instructions that, when invoked by a processor for execution, may perform part or all of the steps or any combination of the steps in the methods for cell image analysis and slide storage in various embodiments of the present application.

In an exemplary embodiment, the present invention also provides a computer-readable storage medium, such as a memory, comprising a computer program executable by a processor of a cell image analysis system to perform the steps of the foregoing method. The computer readable storage medium may be FRAM, ROM, PROM, EPROM, EEPROM, flash Memory, magnetic surface Memory, optical disk, or CD-ROM, or various devices including one or any combination of the above, such as portable analyzers, etc.

In summary, according to the cell image analysis system and the slide storage method thereof according to the embodiments of the present invention, the detected slide is directly placed in the slide box with large capacity and stored for a long period of time, so that the number of times of frequent replacement of the slide box by a user is greatly reduced, the slide blockage caused by filling of the slide box is avoided, and the slide box with large capacity is directly used for long period of time storage, so that the slide storage efficiency is greatly improved without manually transferring the detected slide to the long period of time storage container.

Those of ordinary skill in the art will appreciate that the various illustrative elements and algorithm steps described in connection with the embodiments disclosed herein may be implemented as electronic hardware, or combinations of computer software and electronic hardware. Whether such functionality is implemented as hardware or software depends upon the particular application and design constraints imposed on the solution. Skilled artisans may implement the described functionality in varying ways for each particular application, but such implementation decisions should not be interpreted as causing a departure from the scope of the present invention.

In the several embodiments provided by the present application, it should be understood that the disclosed apparatus and method may be implemented in other ways. For example, the above-described device embodiments are merely illustrative, e.g., the division of the elements is merely a logical functional division, and there may be additional divisions when actually implemented, e.g., multiple elements or components may be combined or integrated into another device, or some features may be omitted or not performed.

In the description provided herein, numerous specific details are set forth. However, it is understood that embodiments of the invention may be practiced without these specific details. In some instances, well-known methods, structures and techniques have not been shown in detail in order not to obscure an understanding of this description.

Similarly, it should be appreciated that in order to streamline the invention and aid in understanding one or more of the various inventive aspects, various features of the invention are sometimes grouped together in a single embodiment, figure, or description thereof in the description of exemplary embodiments of the invention. This method of disclosure, however, is not to be interpreted as reflecting an intention that the claimed invention requires more features than are expressly recited in each claim. Rather, as the following claims reflect, inventive aspects lie in less than all features of a single disclosed embodiment. Thus, the claims following the detailed description are hereby expressly incorporated into this detailed description, with each claim standing on its own as a separate embodiment of this invention.

It will be understood by those skilled in the art that all of the features disclosed in this specification (including any accompanying claims, abstract and drawings), and all of the processes or units of any method or apparatus so disclosed, may be combined in any combination, except combinations where the features are mutually exclusive. Each feature disclosed in this specification (including any accompanying claims, abstract and drawings), may be replaced by alternative features serving the same, equivalent or similar purpose, unless expressly stated otherwise.

Furthermore, those skilled in the art will appreciate that while some embodiments described herein include some features but not others included in other embodiments, combinations of features of different embodiments are meant to be within the scope of the invention and form different embodiments. For example, in the claims, any of the claimed embodiments may be used in any combination.

It should be noted that the above-mentioned embodiments illustrate rather than limit the invention, and that those skilled in the art will be able to design alternative embodiments without departing from the scope of the appended claims. In the claims, any reference signs placed between parentheses shall not be construed as limiting the claim. The word "comprising" does not exclude the presence of elements or steps not listed in a claim. The word "a" or "an" preceding an element does not exclude the presence of a plurality of such elements. The invention may be implemented by means of hardware comprising several distinct elements, and by means of a suitably programmed computer. In the unit claims enumerating several means, several of these means may be embodied by one and the same item of hardware. The use of the words first, second, third, etc. do not denote any order. These words may be interpreted as names.

The foregoing description is merely illustrative of specific embodiments of the present invention and the scope of the present invention is not limited thereto, and any person skilled in the art can easily think about variations or substitutions within the scope of the present invention. The protection scope of the invention is subject to the protection scope of the claims.

Claims

1. A cell image analysis system, the system comprising:

the first glass slide box is used for loading glass slides to be detected, and the glass slides in the first glass slide box are vertically placed;

A control device;

The second glass slide box is used for loading the detected glass slide, the glass slide in the second glass slide box is horizontally placed, and the capacity of the second glass slide box is more than 2 times of that of the first glass slide box.

2. The system of claim 1, wherein the second slide cassette is provided with elastic means for holding the tested slide placed in the second slide cassette, and/or

The second slide box comprises an identification part, wherein the identification part comprises an artificial label and/or an electronic label, the artificial label and/or the electronic label are/is used for recording characteristic information of the second slide box, preferably, the electronic label is also used for recording index information, storage position information, characteristic information of a sample and/or detection result of the sample of each tested slide in the second slide box, and/or

The second glass sheet box is provided with a hand-held device for holding and/or

The second slide box is internally provided with an oil storage device which is used for collecting the mirror oil of the tested slide in the second slide box and/or

The system has a counting part for counting the number of the detected slides in the second slide box, a display part for displaying the position of the detected slides in the second slide box and/or the number of the detected slides in the second slide box, and/or

The system further comprises a prompting device for prompting a user to replace the second glass box when the number of the detected glass in at least one preset area reaches a preset threshold value, and/or

The system further comprises a detection device for detecting whether the second slide box is placed at a preset position before the detected slide is loaded into the second slide box, and the prompting device prompts a user that the second slide box is not placed when the detection device detects that the second slide box is not placed at the preset position.

3. The system of claim 1 or 2, wherein the second cassette comprises a configurable number of adjacent receptacles arranged in a single row or in multiple rows.

4. A system according to any of claims 1-3, wherein the capacity of the second slide cassette is at least 5 times the capacity of the first slide cassette, and/or

The second cassette is configured to hold at least 40 slides, and/or

The first cassette is configured to hold at least 10 slides.

5. The system of any one of claims 1 to 4, wherein the second cassette has a housing and a plurality of slots provided in the housing for receiving slides, the housing having a first side plate and a second side plate on two first side portions disposed opposite each other, each slot being formed by a first support on the first side plate and a second support on the second side plate opposite the first support.

6. The system of claim 5, wherein at least one oil guide channel is formed in at least one of the first side plate and the second side plate.

7. The system of claim 6, wherein at least one oil guide groove extends from at least an uppermost one of the plurality of slots to near the bottom of the housing, preferably at least one oil guide groove extends obliquely from at least an uppermost one of the plurality of slots to near the bottom of the housing, and/or

At least one oil guide groove penetrates through the supporting part of each slot, which is positioned on the side plate where the at least one oil guide groove is positioned, and/or

At least one first oil guiding groove is arranged in at least one side plate of the first side plate and the second side plate, at least one second oil guiding groove is arranged in at least one side plate of the first side plate and the second side plate, the at least one first oil guiding groove extends in the side edge of the side plate where the first oil guiding groove is arranged and does not penetrate through the supporting part of each slot, the at least one second oil guiding groove penetrates through the supporting part of each slot in the side plate where the second oil guiding groove is arranged, and/or

At least one first oil guide groove is formed in the first side plate, at least one second oil guide groove is formed in the second side plate, and the at least one first oil guide groove and the at least one second oil guide groove are asymmetrically arranged.

8. The system of claim 6 or 7, wherein each slot has a length less than the length of the slide, and/or

The length of each slot is less than the length of the slide by at least the length of the label region of the slide.

9. The system according to any one of claims 6 to 8, wherein the housing has openings for access of slides to the slot on each of the two opposing second sides, and/or

Lateral clamping portions are provided on the first and second side plates for each slot, respectively, for clamping a smear in the slot from the smear side, preferably each lateral clamping portion extending obliquely from the respective side plate towards the longitudinal axis of the respective slot, preferably at an angle of about 40 °.

10. A cell image analysis system, the system comprising:

A control device;

The slide loading device is used for loading the slide to be detected to the detection platform along the first direction;

slide unloading means for unloading the slide from the detection platform in the first direction into a recovery slide cassette;

the recovery slide cassette is configured to hold at least 20 slides and is configured to hold the tested slides.