CN1202364A - Oil solutions for remitting angina pectoris - Google Patents
Oil solutions for remitting angina pectoris Download PDFInfo
- Publication number
- CN1202364A CN1202364A CN 97108105 CN97108105A CN1202364A CN 1202364 A CN1202364 A CN 1202364A CN 97108105 CN97108105 CN 97108105 CN 97108105 A CN97108105 A CN 97108105A CN 1202364 A CN1202364 A CN 1202364A
- Authority
- CN
- China
- Prior art keywords
- remitting
- angina pectoris
- oleum
- oil solutions
- acori graminei
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010002383 Angina Pectoris Diseases 0.000 title claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 11
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 11
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 11
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000001914 filtration Methods 0.000 claims abstract description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 3
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 7
- 241000628997 Flos Species 0.000 claims description 7
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 6
- 241000208340 Araliaceae Species 0.000 claims description 6
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 6
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 6
- 235000008434 ginseng Nutrition 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 6
- 239000004570 mortar (masonry) Substances 0.000 claims description 3
- 210000004556 brain Anatomy 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 claims description 2
- 201000010099 disease Diseases 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 239000007788 liquid Substances 0.000 abstract description 4
- 238000002156 mixing Methods 0.000 abstract description 2
- -1 nitrogen ketone Chemical class 0.000 abstract description 2
- 231100000957 no side effect Toxicity 0.000 abstract description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 2
- 238000000605 extraction Methods 0.000 abstract 2
- 229940041616 menthol Drugs 0.000 abstract 2
- 239000003921 oil Substances 0.000 abstract 2
- 244000295724 Allium chinense Species 0.000 abstract 1
- 235000016790 Allium chinense Nutrition 0.000 abstract 1
- 235000002568 Capsicum frutescens Nutrition 0.000 abstract 1
- 241000779819 Syncarpia glomulifera Species 0.000 abstract 1
- 239000010634 clove oil Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 238000012856 packing Methods 0.000 abstract 1
- 239000001739 pinus spp. Substances 0.000 abstract 1
- 229940036248 turpentine Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 231100000862 numbness Toxicity 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000035943 smell Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 229940127291 Calcium channel antagonist Drugs 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003257 anti-anginal effect Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000000480 calcium channel blocker Substances 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000009191 jumping Effects 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000003087 receptor blocking agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The oil solution is prepared with Acori graminei, Allium chinense, notoginseng, chili and menthol in certain proportion as main components and through the steps of crushing and alcohol extraction of the first mentioned four materials, mixing the extraction liquid with menthol as well as nitrogen ketone, clove oil, cinnamic oil and turpentine, filtration, packing and disinfection. It is developed based on the Chinese medical theory of treating internal disease through external treatment and the modern transdermal technology and has fast curative effect and no side effect.
Description
The present invention relates to a kind of Chinese medicine preparation.
Obstruction of qi in the chest and cardialgia (coronary heart disease, angina pectoris) is one of clinical common, multiple cardiovascular disease, gives the human physical and mental health very harmful.At present to the treatment of this disease still based on nitric acid lipid, calcium antagonist, B-receptor blocking agent, route of administration comprises intravenously administrable, sublingual administration, oral administration etc., though they have therapeutical effect preferably aspect antianginal, but the side effect of varying degree is all arranged, and prolonged application easily produces drug resistance.The transdermal methods administration is a kind of novel medication that development in recent years is got up, but all with slow release, controlled release and suitable long-acting be its characteristics.Have Chinese medicine for outer use such as unguentum, patch etc. now, all be difficult to reach the effect of quick-acting antalgesic again.
The present invention's purpose aims to provide a kind of according to the traditional Chinese medical science " inner disease outer treat " principle, in conjunction with modern transdermal new technique, through a kind of pure Chinese medicine external novel formulation---the oil solutions for remitting angina pectoris of clinical, experimentation repeatedly, be used for the treatment of angina pectoris, evident in efficacy, have no side effect.
Technical scheme of the present invention is: it is main component that this oil solutions for remitting angina pectoris adopts Rhizoma Acori Graminei, Bulbus Allii Macrostemonis, Radix Notoginseng, Mentholum, Fructus Capsici, by certain percentage by weight proportioning, during making earlier with Rhizoma Acori Graminei, Bulbus Allii Macrostemonis, Radix Notoginseng is cataclasm, use alcohol reflux, obtain extracting solution, again that Fructus Capsici is cataclasm, use alcohol reflux, obtain extracting solution, both extracting solution and PUHE brain are melted with putting to grind altogether altogether in the mortar, and add azone and Oleum Caryophylli, Oleum Cinnamomi, Oleum Terebinthinae, mix homogeneously, filtration, fill, sterilization, promptly.
The present invention is according to the traditional Chinese medical science " inner disease outer treat " principle, and in conjunction with modern transdermal new technique, through clinical, experimentation repeatedly, a kind of pure Chinese medicine external novel formulation that develops, medication uniqueness, prescription are rigorous, and dosage form design novelty, curative effect are rapid, and the medicine source is extensive.The side is a principal agent with the hot temperature fragrance of Rhizoma Acori Graminei, Bulbus Allii Macrostemonis, the logical breast sun of a surname, Flos Magnoliae, Flos Caryophylli, Fructus Capsici, Cortex Cinnamomi, the Radix Angelicae Dahuricae, Rhizoma Atractylodis, is all thick products of abnormal smells from the patient, or the big heat of Da Xin, or fragrant warm-dryness syndrome, to help the hot Wen Xuantong of principal agent; Benefit is with Radix Ginseng Rubra, Radix Notoginseng benefiting QI for activating blood circulation, to control the accompanied symptoms of its blood stasis due to qi deficiency; Many product in the side only with hot Wen Dare, probably it is too high strong, and the Borneolum Syntheticum, Mentholum that are assistant hot cold (cold) be with slow its warm-dryness syndrome too, and Borneolum Syntheticum is kind especially has one's ideas straightened out, and also helps its a surname to lead to.Oleum Terebinthinae, the two figuration of azone are strengthened drug osmotic for making, and speed the logical gesture of a surname.We's Wen Tongxuan numbness, benefiting QI for activating blood circulation, heart arteries and veins mechanism of qi one are smooth, and it is made by oneself bitterly.
Dosage form: externally-applied liniment.
Function: fragrance a surname numbness, blood-activating analgetic.
Main disease to be treated: obstruction of qi in the chest and cardialgia, i.e. angina pectoris.
Usage: be coated with this product 0.1-0.2ml at every turn and put on the skin in the about 6 * 6cm of front skin
2, every day 3 times.Immediately embrocate during angina pectoris attacks, and can smell nose.
Its percentage by weight of above-mentioned main component is: Rhizoma Acori Graminei 10-20%, Bulbus Allii Macrostemonis 10-20%, Radix Notoginseng 7.5-15%, Mentholum 30-55%, Fructus Capsici 10-20%.
In above-mentioned main prescription, also can add Flos Magnoliae, Borneolum Syntheticum, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Radix Ginseng Rubra becomes the production example prescription, and its percentage by weight is: Rhizoma Acori Graminei 7.5-15%, Bulbus Allii Macrostemonis 7.5-15%, Flos Magnoliae 4.5-9%, Borneolum Syntheticum 7.5-15%, Rhizoma Atractylodis 4.5-9%, Radix Angelicae Dahuricae 7-14%, Radix Ginseng Rubra 4.5-9%, Radix Notoginseng 4.5-9%, Mentholum 20-37.4%, Oleum Caryophylli 1-3%, Oleum Cinnamomi 2-5%, Fructus Capsici 7.5-15%, Oleum Terebinthinae 1-3%, azone 2-6%.
Above-mentioned main prescription and embodiment its preparation technology that writes out a prescription is:
With Rhizoma Acori Graminei, Bulbus Allii Macrostemonis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Flos Magnoliae, Radix Ginseng Rubra, Radix Notoginseng is cataclasm one-tenth coarse granule, with 95% alcohol reflux twice, each 2 hours, merge extractive liquid, reclaimed ethanol; Fructus Capsici is cataclasm separately, and with 95% alcohol reflux twice, each 2 hours, merge extractive liquid, reclaimed ethanol; Melt with Borneolum Syntheticum, Mentholum and with putting to grind altogether altogether in the mortar, to there not being coarse granule, and while grinding the adding azone, add Oleum Caryophylli, Oleum Cinnamomi, Oleum Terebinthinae again, fully stir, mix homogeneously is with all medicinal liquid mixings, stir, refilter, in the filtrate filling bottle, the gland of jumping a queue, scalding 30 minutes, promptly.
Claims (4)
1, a kind of oil solutions for remitting angina pectoris, it is characterized in that adopting Rhizoma Acori Graminei, Bulbus Allii Macrostemonis, Radix Notoginseng, Mentholum, Fructus Capsici is main component, by certain percentage by weight proportioning, during making earlier with Rhizoma Acori Graminei, Bulbus Allii Macrostemonis, Radix Notoginseng is cataclasm, use alcohol reflux, obtain extracting solution, again that Fructus Capsici is cataclasm, use alcohol reflux, obtain extracting solution, both extracting solution and PUHE brain are melted with putting to grind altogether altogether in the mortar, and add azone and Oleum Caryophylli, Oleum Cinnamomi, Oleum Terebinthinae, mix homogeneously, filtration, fill, sterilization, promptly.
2, oil solutions for remitting angina pectoris according to claim 1 is characterized in that described certain percentage by weight proportioning is: Rhizoma Acori Graminei 10-20%, Bulbus Allii Macrostemonis 10-20%, Radix Notoginseng 7.5-15%, Mentholum 30-55%, Fructus Capsici 10-20%.
3, oil solutions for remitting angina pectoris according to claim 1 is characterized in that also can adding Flos Magnoliae, Borneolum Syntheticum, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Radix Ginseng Rubra.
4, oil solutions for remitting angina pectoris according to claim 1 is characterized in that the percentage by weight proportioning is: Rhizoma Acori Graminei 7.5-15%, Bulbus Allii Macrostemonis 7.5-15%, Flos Magnoliae 4.5-9%, Borneolum Syntheticum 7.5-15%, Rhizoma Atractylodis 4.5-9%, Radix Angelicae Dahuricae 7-14%, Radix Ginseng Rubra 4.5-9%, Radix Notoginseng 4.5-9%, Mentholum 20-37.4%, Oleum Caryophylli 1-3%, Oleum Cinnamomi 2-5%, Fructus Capsici 7.5-15%, Oleum Terebinthinae 1-3%, azone 2-6%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97108105 CN1202364A (en) | 1997-06-13 | 1997-06-13 | Oil solutions for remitting angina pectoris |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97108105 CN1202364A (en) | 1997-06-13 | 1997-06-13 | Oil solutions for remitting angina pectoris |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1202364A true CN1202364A (en) | 1998-12-23 |
Family
ID=5170133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 97108105 Pending CN1202364A (en) | 1997-06-13 | 1997-06-13 | Oil solutions for remitting angina pectoris |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1202364A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008501788A (en) * | 2004-06-09 | 2008-01-24 | ピュリメド カンパニー リミテッド | Ishizuchi extract for prevention or treatment of ischemic heart disease, pharmaceutical composition containing the same and health food |
| WO2010127411A1 (en) * | 2009-05-08 | 2010-11-11 | Allmedic Pty Ltd | Treatment of pain and/or inflammation and treatment and prevention of a skin or mucosal disease and/or condition |
| CN101843753B (en) * | 2009-12-09 | 2011-07-20 | 北京绿源求证科技发展有限责任公司 | Chinese medicament for treating angina |
| CN108310314A (en) * | 2018-03-06 | 2018-07-24 | 杭州益寿生物医药科技有限公司 | A kind of composition of plant extracts for analgesic |
-
1997
- 1997-06-13 CN CN 97108105 patent/CN1202364A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008501788A (en) * | 2004-06-09 | 2008-01-24 | ピュリメド カンパニー リミテッド | Ishizuchi extract for prevention or treatment of ischemic heart disease, pharmaceutical composition containing the same and health food |
| EP1793690A4 (en) * | 2004-06-09 | 2009-07-29 | Purimed Co Ltd | Acorus gramineus soland extract for preventing and treating ischemic heart disease and pharmaceutical composition and health food containing the same |
| WO2010127411A1 (en) * | 2009-05-08 | 2010-11-11 | Allmedic Pty Ltd | Treatment of pain and/or inflammation and treatment and prevention of a skin or mucosal disease and/or condition |
| AU2010244983B2 (en) * | 2009-05-08 | 2015-07-16 | Allmedic Pty Ltd | Treatment of pain and/or inflammation and treatment and prevention of a skin or mucosal disease and/or condition |
| CN101843753B (en) * | 2009-12-09 | 2011-07-20 | 北京绿源求证科技发展有限责任公司 | Chinese medicament for treating angina |
| CN108310314A (en) * | 2018-03-06 | 2018-07-24 | 杭州益寿生物医药科技有限公司 | A kind of composition of plant extracts for analgesic |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |