CN1271990C - Liquid cosmetics - Google Patents
Liquid cosmetics Download PDFInfo
- Publication number
- CN1271990C CN1271990C CNB031193587A CN03119358A CN1271990C CN 1271990 C CN1271990 C CN 1271990C CN B031193587 A CNB031193587 A CN B031193587A CN 03119358 A CN03119358 A CN 03119358A CN 1271990 C CN1271990 C CN 1271990C
- Authority
- CN
- China
- Prior art keywords
- composition
- ascorbic acid
- liquid make
- sodium
- ascorbyl phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 36
- 239000002537 cosmetic Substances 0.000 title abstract description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- -1 polyoxypropylene Polymers 0.000 claims abstract description 19
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 8
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 24
- 229960005070 ascorbic acid Drugs 0.000 claims description 12
- 239000002211 L-ascorbic acid Substances 0.000 claims description 11
- 235000000069 L-ascorbic acid Nutrition 0.000 claims description 11
- 229940078752 magnesium ascorbyl phosphate Drugs 0.000 claims description 11
- 229940048058 sodium ascorbyl phosphate Drugs 0.000 claims description 8
- HRUVKSKSDDVGMC-JDYVBSGKSA-L disodium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;sulfate Chemical compound [Na+].[Na+].OS([O-])(=O)=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] HRUVKSKSDDVGMC-JDYVBSGKSA-L 0.000 claims description 4
- 239000004260 Potassium ascorbate Substances 0.000 claims description 2
- BLTFCXKOBQLMDR-JDYVBSGKSA-L [K+].[K+].[O-]S([O-])(=O)=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O Chemical compound [K+].[K+].[O-]S([O-])(=O)=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O BLTFCXKOBQLMDR-JDYVBSGKSA-L 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- 229940074358 magnesium ascorbate Drugs 0.000 claims description 2
- CVNIWQIEKVYHHB-PQYRJTSOSA-L magnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;sulfate Chemical compound [Mg+2].[O-]S([O-])(=O)=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CVNIWQIEKVYHHB-PQYRJTSOSA-L 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 229940017794 potassium ascorbate Drugs 0.000 claims description 2
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims description 2
- 229960005055 sodium ascorbate Drugs 0.000 claims description 2
- 229920001451 polypropylene glycol Polymers 0.000 abstract description 8
- 150000000996 L-ascorbic acids Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 18
- 206010009866 Cold sweat Diseases 0.000 description 16
- 230000035807 sensation Effects 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 12
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 11
- 238000000034 method Methods 0.000 description 9
- 239000000843 powder Substances 0.000 description 5
- 239000001509 sodium citrate Substances 0.000 description 5
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 5
- 230000002087 whitening effect Effects 0.000 description 5
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 4
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- 230000002421 anti-septic effect Effects 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000004359 castor oil Substances 0.000 description 3
- 235000019438 castor oil Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- HBXWUCXDUUJDRB-UHFFFAOYSA-N 1-octadecoxyoctadecane Chemical compound CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC HBXWUCXDUUJDRB-UHFFFAOYSA-N 0.000 description 2
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 244000042664 Matricaria chamomilla Species 0.000 description 2
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical group CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Polymers OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 235000014593 oils and fats Nutrition 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 229950009883 tocopheryl nicotinate Drugs 0.000 description 2
- OBETXYAYXDNJHR-SSDOTTSWSA-M (2r)-2-ethylhexanoate Chemical compound CCCC[C@@H](CC)C([O-])=O OBETXYAYXDNJHR-SSDOTTSWSA-M 0.000 description 1
- FEOHYDSNGHIXOM-WLDMJGECSA-N (3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)-2-methyloxane-2,4,5-triol Chemical compound CC1(O)[C@H](N)[C@@H](O)[C@H](O)[C@H](O1)CO FEOHYDSNGHIXOM-WLDMJGECSA-N 0.000 description 1
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 1
- DBTMGCOVALSLOR-UHFFFAOYSA-N 32-alpha-galactosyl-3-alpha-galactosyl-galactose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(OC2C(C(CO)OC(O)C2O)O)OC(CO)C1O DBTMGCOVALSLOR-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- 241000195940 Bryophyta Species 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- RXVWSYJTUUKTEA-UHFFFAOYSA-N D-maltotriose Natural products OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(O)C(CO)O1 RXVWSYJTUUKTEA-UHFFFAOYSA-N 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- 244000178870 Lavandula angustifolia Species 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- RFMMMVDNIPUKGG-YFKPBYRVSA-N N-acetyl-L-glutamic acid Chemical compound CC(=O)N[C@H](C(O)=O)CCC(O)=O RFMMMVDNIPUKGG-YFKPBYRVSA-N 0.000 description 1
- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- VYGQUTWHTHXGQB-UHFFFAOYSA-N Retinol hexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-UHFFFAOYSA-N 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000012644 addition polymerization Methods 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940044176 ceramide 3 Drugs 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Natural products C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- BEGBSFPALGFMJI-UHFFFAOYSA-N ethene;sodium Chemical group [Na].C=C BEGBSFPALGFMJI-UHFFFAOYSA-N 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 239000000138 intercalating agent Substances 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical class O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- FYGDTMLNYKFZSV-UHFFFAOYSA-N mannotriose Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(O)C(O)C2O)CO)C(O)C1O FYGDTMLNYKFZSV-UHFFFAOYSA-N 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 235000011929 mousse Nutrition 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940045635 sodium pyroglutamate Drugs 0.000 description 1
- CRPCXAMJWCDHFM-DFWYDOINSA-M sodium;(2s)-5-oxopyrrolidine-2-carboxylate Chemical compound [Na+].[O-]C(=O)[C@@H]1CCC(=O)N1 CRPCXAMJWCDHFM-DFWYDOINSA-M 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61G—TRANSPORT, PERSONAL CONVEYANCES, OR ACCOMMODATION SPECIALLY ADAPTED FOR PATIENTS OR DISABLED PERSONS; OPERATING TABLES OR CHAIRS; CHAIRS FOR DENTISTRY; FUNERAL DEVICES
- A61G5/00—Chairs or personal conveyances specially adapted for patients or disabled persons, e.g. wheelchairs
- A61G5/02—Chairs or personal conveyances specially adapted for patients or disabled persons, e.g. wheelchairs propelled by the patient or disabled person
- A61G5/024—Chairs or personal conveyances specially adapted for patients or disabled persons, e.g. wheelchairs propelled by the patient or disabled person having particular operating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61G—TRANSPORT, PERSONAL CONVEYANCES, OR ACCOMMODATION SPECIALLY ADAPTED FOR PATIENTS OR DISABLED PERSONS; OPERATING TABLES OR CHAIRS; CHAIRS FOR DENTISTRY; FUNERAL DEVICES
- A61G5/00—Chairs or personal conveyances specially adapted for patients or disabled persons, e.g. wheelchairs
- A61G5/08—Chairs or personal conveyances specially adapted for patients or disabled persons, e.g. wheelchairs foldable
- A61G5/0875—Chairs or personal conveyances specially adapted for patients or disabled persons, e.g. wheelchairs foldable dismountable, e.g. where the wheelchair can be disassembled for transportation or storage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61G—TRANSPORT, PERSONAL CONVEYANCES, OR ACCOMMODATION SPECIALLY ADAPTED FOR PATIENTS OR DISABLED PERSONS; OPERATING TABLES OR CHAIRS; CHAIRS FOR DENTISTRY; FUNERAL DEVICES
- A61G5/00—Chairs or personal conveyances specially adapted for patients or disabled persons, e.g. wheelchairs
- A61G5/10—Parts, details or accessories
- A61G5/1005—Wheelchairs having brakes
- A61G5/101—Wheelchairs having brakes of the parking brake type, e.g. holding the wheelchair
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cosmetics (AREA)
Abstract
The present invention provided a liquid cosmetic having excellent sense of use even in the presence of a water-soluble L-ascorbic acid derivative. The liquid cosmetic comprises (a) a specific polyoxypropylene diglyceryl, (b) 0.5-5 wt.% of the water-soluble L-ascorbic acid derivative, (c) one or more kinds of polyhydric alcohols containing three or more hydroxy groups as essential components and (d) ethanol in the content mass ratio of the component (a) to the component (b) of 1:10-10:1.
Description
Technical field
The present invention relates under the situation that the water solublity L-ascorbic acid derivates that uses as whitening composition exists, have high moistening effect and skin care effect and the usability better fluid cosmetics of the sensation that is not clamminess.
Background technology
Water solublity ascorbic acid derivates in the past has good whitening effect because of it, and is widely used in preparing cosmetics.But, if these cosmetics contain a large amount of water miscible L-ascorbic acid derivates, will produce the sensation of unique sensation that is clamminess and formation mucosa, feeling after the use is very bad.In order to obtain good usability, prior art has adopted the method for high molecular weight materials such as sneaking into water soluble polymer, wax, powder respectively and has sneaked into the sensation that the method for wet goods lubricant suppresses to be clamminess.For example, can sneak into dextrin fatty acid ester (spy opens the claim and the technical field part of 2002-020529 communique), voluminous powder and/or water absorption powder (spy opens the claim and the technical field part of 2002-104919 communique), water soluble polyether dimethyl polysiloxane (spy opens the claim and the technical field part of 2000-290128 communique), silicone oil (spy opens the page 2 of 2001-151623 communique, goes to the 16th from upper right the 6th row) etc.
Summary of the invention
But, when these methods are used for mobile liquid make-up, the usability better fluid cosmetics of the very difficult technically sensation that obtains to have the skin care effect and be not clamminess.In view of the foregoing, the invention provides the usability better fluid cosmetics that contain water solublity L-ascorbic acid derivates.
The present inventor is for solving above-mentioned problem, further investigate, it found that, in the liquid make-up that contains water solublity L-ascorbic acid derivates, if contain polyoxypropylene diglycerol and polyhydric alcohol with three above hydroxyls, just can obtain good usability, finish the present invention thus.
That is, the present invention relates to liquid make-up, this liquid make-up contains the following ingredients (a)～(c) as neccessary composition:
(a) polyoxypropylene diglycerol,
(b) the water solublity L-ascorbic acid derivates of 0.5～5 quality %,
(c) has the polyhydric alcohol of three above hydroxyls.
And, the present invention relates to also contain the alcoholic acid liquid make-up of composition (d), and the mass ratio that relates to composition (a) and composition (b) is 1: 10～10: 1 a liquid make-up.
Below composition of the present invention is described.
The composition that uses among the present invention (a) polyoxypropylene diglycerol is used to suppress the sensation that is clamminess that composition (b) water solublity L-ascorbic acid derivates is produced.Composition (a) is for having the material as the structure of following general formula 1 expression.Composition (a) is the chemical compound that the addition polymerization oxypropylene obtains in the diglycerol, there is no particular limitation to the average addition molal quantity of oxypropylene, but consider from the effect of the sensation that suppresses to be clamminess, with respect to per 1 mole of diglycerol, preferred 5～20 moles average addition molal quantity.
[general formula 1]
(preferred m+n+o+p=5～20)
Can select one or more described polyoxypropylene diglycerols to be used in combination as required.The example of the commercial articles of described composition (a) such as Savondol GP-9 (Japanese oils and fats), PristolDGP-09 (ミ ヨ シ oils and fats), SY-DP9, SY-DP14 (above is the preparation of this pharmaceutical industries of slope) etc.
With respect to the gross mass of liquid make-up, the content of the composition that uses among the present invention (a) is preferably 0.001～30 quality % (following usefulness " % " expression, " the quality % " in this description and " weight % " same meaning.), more preferably 0.1～10%.In this scope, can obtain having the good skin care and the liquid make-up of moistening effect.
The composition that uses among the present invention (b) water solublity L-ascorbic acid derivates is used to give the whitening effect of cosmetics, itself so long as water-soluble substances just there is no particular limitation.Its concrete example as, L-sodium ascorbate, L-potassium ascorbate, L-Magnesium ascorbate, L-sodium ascorbyl phosphate, L-magnesium ascorbyl phosphate, L-sodium ascorbyl phosphate potassium, L-ascorbic acid sodium sulfate, L-ascorbic acid magnesium sulfate, L-ascorbic acid potassium sulfate etc.Wherein, from the self stability of medicament and the simplicity when mixing consider preferred L-magnesium ascorbyl phosphate, L-sodium ascorbyl phosphate, L-ascorbic acid sodium sulfate.Can select one or more described combinations of substances to use as required.
With respect to the gross mass of liquid make-up, the content of the composition that uses among the present invention (b) is preferably 0.5～5%, and more preferably 1～3%.In this scope, can obtain having good whitening effect and skin care effect and the moisture retention better fluid cosmetics of the sensation that is not clamminess.
The polyhydric alcohol that the composition that uses among the present invention (c) has three above hydroxyls is used to give the moistening effect of cosmetics.Described intramolecularly has the glycerol that contract such as the example of polyhydric alcohol of three above hydroxyls such as glycerol, diglycerol, triglycerin, four glycerol, maltose, maltose alcohol, sucrose, fructose, xylitol, Sorbitol, maltotriose, erithritol and their polythene derivative, glucosan derivative etc. more.Wherein, consider that preferred intramolecularly has the polyhydric alcohol of 3～10 hydroxyls from moistening effect.Can use one or more described polyhydric alcohol as required with three above hydroxyls.
With respect to the gross mass of liquid make-up, the content of described composition (c) is preferably 0.001～30%, and more preferably 0.1～10%.In this scope, can obtain moistening effect especially fully.
Because liquid make-up of the present invention contains mentioned component (a)～(c), and has good usability.Because liquid make-up of the present invention also contains composition (d) ethanol, and the sensation that has better skin care effect and more can suppress to be clamminess.With respect to the gross mass of liquid make-up, the content of described composition (d) is preferably 1～30%, and more preferably 3～20%.
And, if the mass ratio (a) of mentioned component (a) and composition (b):, more preferably in 1: 5～5: 1 scopes, just can suppress the sensation that is clamminess better, and further improve effect of the present invention (b) at 1: 10～10: 1.(" mass ratio " and " weight ratio " same meaning in this description.)
In addition, the liquid condition of liquid make-up of the present invention is meant when using to have mobile state under general state, and its viscosity number at 20 ℃ is 5～40,000mPas.Preferred 10～20,000mPas, more preferably 10～5, in the scope of 000mPas, be expected to obtain having the liquid make-up of good more usability.
There is no particular limitation to the compound method of liquid make-up of the present invention, but can suitably select according to the formula property of cosmetics.Have for instance, surfactant and oil preparation etc. is dissolved in the ethanol, be dispersed in the condensing method of preparing in the water then; With the method for the mechanical force preparation that utilizes high-pressure homogenizer etc. etc.
Liquid make-up of the present invention can also be as medical exterior-applied article and topical drug etc. except can be used as cosmetics.The example of described cosmetics comprises, various liquid preparations such as astringent, beautifying liquid, fragrant composition.And also available known method is made described liquid make-up in preparations such as spray, mousse, and it is immersed on non-woven fabrics etc. make the film like preparation.
In the scope that does not influence effect of the present invention, liquid make-up of the present invention can contain the composition that generally uses in the fields such as cosmetics, medical exterior-applied article and external pharmaceuticals.For example, surfactant, oil preparation, wetting agent, polymer substance, UV absorbent, multivalent intercalating agent, nertralizer, pH regulator agent, antioxidant, antibacterial, antiseptic, pigment, powder body, pigment, spice, drug effect agent etc. can suitably be used as required.
The specific embodiment
[embodiment]
The following examples have further described the present invention, but the present invention is not limited to these embodiment.
Embodiment 1～12 and comparative example 1～5; Astringent
The astringent of preparation composition as table 1 (embodiment) and table 2 (comparative example) shown in to usability, promptly has or not three of the sensation that is clamminess, skin care effect, moistening effects etc. to estimate.
Table 1
| Composition | Embodiment (%) | ||||||||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | ||
| 1 | Polyoxypropylene (9) diglycerol | 1 | 1 | 1 | 10 | 0.3 | 10 | 1 | 0.5 | - | 1 | 1 | 10 |
| 2 | Polyoxypropylene (14) diglycerol | - | - | - | - | - | - | - | - | 1 | - | - | - |
| 3 | Glycerol | 5 | - | - | 5 | 5 | 5 | 5 | 0.5 | 5 | 5 | 5 | 5 |
| 4 | Maltose alcohol | - | 5 | - | - | - | - | - | - | - | - | - | - |
| 5 | Triglycerin | - | - | 5 | - | - | - | - | - | - | - | - | - |
| 6 | The L-magnesium ascorbyl phosphate | 3 | 3 | 3 | 3 | 3 | 1 | 1 | 0.5 | 3 | 3 | - | - |
| 7 | The L-sodium ascorbyl phosphate | - | - | - | - | - | - | - | - | - | - | 3 | 1 |
| 8 | Sodium citrate | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 |
| 9 | Pure water | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus |
| 10 | Ethanol | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | - | 10 | 10 |
| 11 | Dipropylene glycol | - | - | - | - | - | - | - | - | - | 10 | - | - |
| 12 | Polyethylene glycol oxide (60) hardened castor oil | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 |
| Composition (a)/composition (b) | 1/3 | 1/3 | 1/3 | 10/ 3 | 1/1 0 | 10/ 1 | 1/1 | 1/1 | 1/3 | 1/3 | 1/3 | 10/ 1 | |
| Judge | Have or not the sensation that is clamminess | ◎ | ◎ | ○ | ◎ | ○ | ◎ | ◎ | ◎ | ◎ | ○ | ◎ | ◎ |
| The skin care effect | ◎ | ◎ | ◎ | ○ | ○ | ○ | ◎ | ◎ | ◎ | ○ | ◎ | ○ | |
| Moistening effect | ◎ | ◎ | ◎ | ◎ | ○ | ◎ | ◎ | ○ | ◎ | ◎ | ◎ | ◎ | |
Table 2
| Composition | Comparative example (%) | |||||
| 1 | 2 | 3 | 4 | 5 | ||
| 1 | Polyoxypropylene (9) diglycerol | - | - | 1 | 2 | 6 |
| 2 | Polyoxypropylene (14) diglycerol | - | - | - | - | - |
| 3 | Glycerol | - | 5 | - | 5 | 5 |
| 4 | Maltose alcohol | - | - | - | - | - |
| 5 | Triglycerin | - | - | - | - | - |
| 6 | The L-magnesium ascorbyl phosphate | 3 | 3 | 3 | 6 | 6 |
| 7 | The L-sodium ascorbyl phosphate | - | - | - | - | - |
| 8 | Sodium citrate | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 |
| 9 | Pure water | Surplus | Surplus | Surplus | Surplus | Surplus |
| 10 | Ethanol | 10 | 10 | 10 | 10 | 10 |
| 11 | Dipropylene glycol | - | - | - | - | - |
| 12 | Polyethylene glycol oxide (60) hardened castor oil | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 |
| Composition (a)/composition (b) | - | - | 1/3 | 1/3 | 1/1 | |
| Judge | Have or not the sensation that is clamminess | × | × | ○ | × | △ |
| The skin care effect | × | × | × | △ | × | |
| Moistening effect | × | ○ | × | ○ | ○ | |
Preparation method
A: with composition 1～9 at 40 ℃ of mixed dissolutions.
B: composition 10～12 is dissolved in mixed at room temperature.
C: in B, add A, mix obtaining astringent.
The decision method of usability
Usability (having or not the sensation, skin care effect, the moistening effect that are clamminess) after being coated in astringent on the skin by 10 professional judges' evaluations divides 5 ranks with following evaluation criterion, judges according to its average mark.
[evaluation criterion]
5 minutes: very good
4 minutes: good
3 minutes: general
2 minutes: bad
1 minute: very bad
[criterion]
◎: average mark is more than 4.5 minutes
Zero: average mark 3.5 minutes～4.5 minutes
△: average mark 2.5 minutes～3.5 minutes
*: average mark is below 2.5 minutes
The result who obtains by above evaluation methodology is as table 1, shown in the table 2.
Shown in the result of table 1, the astringent of the embodiment of the invention 1～12 even sneaked into water solublity L-magnesium ascorbyl phosphate, L-sodium ascorbyl phosphate, also can obtain good usability.In contrast, the comparative example 1～5 of table 2 can not be met the astringent of all assessment items.
Embodiment 13: astringent
(composition) (%)
1, polyoxyethylene (60) hardened castor oil 0.3
2, the oil-soluble Radix Glycyrrhizae extract 0.01
3, vitamin E Nicotinate 0.01
4, ethanol 5.0
5, glycerol 10.0
6, polyoxyethylene (10) methyl glucosamine 2.0
7, the L-magnesium ascorbyl phosphate 3.0
8, polyoxypropylene (9) diglycerol 0.5
9, citric acid 0.01
10, sodium citrate 0.03
11, the Chamomile extracting solution 0.01
12, Garden lavender water 0.01
13, the L-arginine 0.1
14, antiseptic is an amount of
15, pure water surplus
Preparation method
A: with composition 1～4 at 40 ℃ of mixed dissolutions.
B: composition 5～15 is dissolved in mixed at room temperature.
C: in B, add A, mix obtaining astringent.
The astringent of embodiment 13 is to have the astringent that is clamminess and feels few, have the skin care effect abundant moistening effect, that produced by water solublity L-magnesium ascorbyl phosphate.
Embodiment 14: astringent
(composition) (%)
1, the different stearyl ether 0.1 of polyoxyethylene (40)
2, the different stearyl ether 0.05 of polyoxyethylene (20)
3, polyoxyethylene (6) alkyl (C12-18) ether phosphoric acid 0.1
4, olive oil 0.2
5, natural Vitamin E 0.2
6, the oil-soluble Herba Rosmarini Officinalis extract 0.01
7, vitamin E Nicotinate 0.01
8, ethanol 10.0
9, Sorbitol 3.0
10, polyoxypropylene (14) diglycerol 3.0
11, sodium citrate 0.5
12, sodium ethylene diamine tetracetate (EDT) 0.03
13, the Semen Coicis extracting solution 0.01
14, the Chamomile extracting solution 0.1
15, the L-magnesium ascorbyl phosphate 1.0
16, sodium pyroglutamate 0.2
17, sodium lactate 0.1
18, aqueous solution of sodium hyaluronate (1%) 2.0
19, antiseptic is an amount of
20, pure water surplus
Preparation method
A: with composition 1～8 at 40 ℃ of mixed dissolutions.
B: composition 9～20 is dissolved in mixed at room temperature.
C: in B, add A, mix obtaining astringent.
The astringent of embodiment 14 is the astringent that is clamminess and feels few, have abundant skin moistening effect and long-time stability that is produced by water solublity L-magnesium ascorbyl phosphate.
Embodiment 15: beautifying liquid
(composition) (%)
1, the hydrogenation soybean phospholipid 1.0
2, polyoxyethylene (10) cholesterol ethers 0.03
3, ceramide 3 0.1
4, stearic acid 0.01
5, three (2 ethyl hexanoic acid) glyceride 0.05
6, the oil-soluble Radix Glycyrrhizae extract 0.01
7, vitamin A palmitate 0.01
8, dipropylene glycol 5.0
9, pure water 15.0
10, L-ascorbic acid sodium sulfate 1.0
11, sodium citrate 0.05
12, ethanol 3.0
13,, the Fructus cydoniae oblongae seed extract 15.0
14, polyoxypropylene (9) diglycerol 1.0
15, diglycerol 5.0
16, the aqueous solution 30.0 of 1% (folder) oxa-grace rubber
17, acetylglutamate 0.3
18, spherical nylon powder 1.0
19, antiseptic is an amount of
20, pure water surplus
Preparation method
A: with composition 1～8 at 85 ℃ of mixed dissolutions.
B: 85 ℃ of heating, the limit is fully stirred to wherein adding A in the limit with composition 9.
C: cooling B, carry out corpusculed by high-pressure homogenizer.
D: composition 10～20 is dissolved in mixed at room temperature.
E: in D, add C, mix obtaining beautifying liquid.
The beautifying liquid of embodiment 15 is the beautifying liquid that is clamminess and feels few, have abundant moistening effect and good usability that is produced by water solublity L-magnesium ascorbyl phosphate.
As mentioned above, liquid make-up of the present invention not only has the whitening function of water solublity L-ascorbic acid derivates, and also can obtain good usability under the situation that water solublity L-ascorbic acid derivates exists.
Claims (3)
1, a kind of liquid make-up is characterized in that, this liquid make-up contains the following ingredients (a)～(c) as neccessary composition:
(a) polyoxypropylene diglycerol,
(b) the water solublity L-ascorbic acid derivates of 0.5～5 quality %, described water solublity L-ascorbic acid derivates is selected from a kind of in the group of being made up of L-sodium ascorbate, L-potassium ascorbate, L-Magnesium ascorbate, L-sodium ascorbyl phosphate, L-magnesium ascorbyl phosphate, L-sodium ascorbyl phosphate potassium, L-ascorbic acid sodium sulfate, L-ascorbic acid magnesium sulfate, L-ascorbic acid potassium sulfate or more than 2 kinds
(c) has the polyhydric alcohol of three above hydroxyls.
2, liquid make-up as claimed in claim 1 is characterized in that, this liquid make-up also contains composition (d) ethanol.
3, the liquid make-up described in claim 1 or 2 is characterized in that, the mass ratio of described composition (a) and composition (b) is 1: 10～10: 1.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002089111 | 2002-03-27 | ||
| JP089111/2002 | 2002-03-27 | ||
| JP2002327142A JP2004002281A (en) | 2002-03-27 | 2002-11-11 | Liquid cosmetic |
| JP327142/2002 | 2002-11-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1446533A CN1446533A (en) | 2003-10-08 |
| CN1271990C true CN1271990C (en) | 2006-08-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031193587A Expired - Lifetime CN1271990C (en) | 2002-03-27 | 2003-03-14 | Liquid cosmetics |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP2004002281A (en) |
| KR (1) | KR20030077968A (en) |
| CN (1) | CN1271990C (en) |
| TW (1) | TWI282740B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2673253C (en) * | 2006-12-26 | 2014-08-26 | Romano Development Inc. | Skin lightening composition for hyperpigmented skin |
| JP6973919B2 (en) * | 2017-09-06 | 2021-12-01 | 株式会社ノエビア | External skin preparation |
-
2002
- 2002-11-11 JP JP2002327142A patent/JP2004002281A/en active Pending
-
2003
- 2003-03-04 TW TW092104511A patent/TWI282740B/en not_active IP Right Cessation
- 2003-03-13 KR KR10-2003-0015590A patent/KR20030077968A/en not_active Ceased
- 2003-03-14 CN CNB031193587A patent/CN1271990C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HK1058001A1 (en) | 2004-04-30 |
| JP2004002281A (en) | 2004-01-08 |
| TW200304382A (en) | 2003-10-01 |
| CN1446533A (en) | 2003-10-08 |
| TWI282740B (en) | 2007-06-21 |
| KR20030077968A (en) | 2003-10-04 |
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