CN1248179C - Coronary artery stenosis model and its producing method - Google Patents
Coronary artery stenosis model and its producing method Download PDFInfo
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- CN1248179C CN1248179C CN 200410057396 CN200410057396A CN1248179C CN 1248179 C CN1248179 C CN 1248179C CN 200410057396 CN200410057396 CN 200410057396 CN 200410057396 A CN200410057396 A CN 200410057396A CN 1248179 C CN1248179 C CN 1248179C
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Abstract
The present invention discloses a coronary artery stenosis model and a fabricating method thereof. Stenosis models with different stenosis degrees and different stenosis positions can be fabricated optionally on any positions of the left or the right coronary artery of an excised pig heart by using a surgical suture method or ligating the coronary artery. The present invention has the advantages of high quality and low cost, and simple processes and requirements of fabrication; the biological histology characteristics of the pig heart are fully consistent with that of a human body, and the model has the characteristic of human simulation; with thin and tiny blood vessels, medical imageology research of CT, or MRI, etc. can be done with pertinence; the present invention can be applied to research of coronary artery imaging, coronary artery stenosis, coronary artery histology and other aspects, particularly research on medical imageology.
Description
[technical field]
The present invention relates to a kind of coronary artery stenosis model and preparation method thereof.
[background technology]
The medical image method of new coronary imaging, such as spiral CT, magnetic resonance and electron beam ct, be applied to clinical before, must verify the accuracy of their clinical practice, and such research can not be implemented on human body, after must finishing animal or Study of model earlier, just can be used for clinical.
External expert Renandin and Davros have reported the method for making of coronary artery model and arteria renalis model respectively, they all adopt liquid resin (liquid resin) material of similar plastics, adopt computer-aided design (CAD) and area of computer aided manufacture craft to make.
Resin mould can be used for studying computerized tomography (CT) scanning machine equipment or accuracy and the error of magnetic resonance imaging machine (MRI) when blood vessel imaging.But area of computer aided modelling equipment is extremely expensive, and manufacture craft is loaded down with trivial details, data demand precision height, and therefore making the coronary artery model can not form scale, and application is restricted.Secondly, the resin mould material is a duroplasts, and is very big with human heart tissue density difference, thereby can not reflect real tissue characteristics.The 3rd, resin material can not make＜the coronary artery model (it is not enough to make precision) of 1.0mm diameter, the assessment of little blood vessel is restricted.
Marcus adopts the stripped coronary artery of monkey to study, and mainly studies higher fatty acid pathological change coronarius after the meal, but not the research of coronary artery stenosis.
[summary of the invention]
The problem that the present invention need solve just is to provide a kind of coronary artery stenosis model and preparation method thereof.
For addressing the above problem, the present invention adopts following technical scheme:
Coronary artery stenosis model of the present invention, it is any position on the arteria coroaria sinistra of isolated pig heart and arteria coronaria dextra, can make the narrow model of different stenosis, different narrow positions arbitrarily.
The present invention also provides a kind of method for making of coronary artery stenosis model, and it is made by the isolated pig heart.
Method for making of the present invention comprises the following steps:
(1) the isolated pig heart cleans and checks;
(2) adopt surgical sutures method or ligation coronary artery;
(3) conventional coronarography confirms narrow model;
(4) inspection of experimental techniques such as row CT or MRI behind the normal saline flushing.
(5) Computer Processing image forms the three-dimensional structure image;
(6) CT or MRI 3-D view and conventional coronarography contrast.
The invention has the advantages that:
The first, " inexpensive ", every isolated pig heart only needs about 10 yuans, and surgery ligation sutures etc. are hardly with cost.
The second, manufacture craft and requirement are simple, only need a pin one line to finish.
The 3rd, pig heart biological histology characteristic and human body are in full accord, and Medical Imaging researchs such as CT or MRI have more specific aim.
The 4th, the isolated pig heart coronary artery is dissected similar to human body, and model possesses " personification " most, and branch vessel is tiny, is that other method can not be made.
The 5th, at the arteria coroaria sinistra (LAD) of isolated pig heart and any position on the arteria coronaria dextra (RCA), can make the narrow model of different stenosis, different narrow positions arbitrarily controls such as () taking back, take over arbitrarily.
[description of drawings]
The narrow model that Fig. 1 shows for the conventional coronarography of the present invention.
The EBCT that Fig. 2 shows for the present invention is to the imaging of same model.
[embodiment]
(1) adopt 28 of the fresh pig hearts that the market of farm produce buys, visual inspection does not have breakage and vessel branch complete, and the heart size is close with human body, and weight is at 350～540 grams, and average 461 ± 50 restrain.Arteria coroaria sinistra of pig heart (LAD) and arteria coronaria dextra (RCA) and organization of human body and out of shape very approaching.
(2) at first finish " flood-pot-test " in the laboratory, promptly LAD and the RCA to pig heart injects physiological saline respectively, outmoded thrombus cleaned up, and confirm that LAD and RCA do not have breakage, and branch is complete.Practical application LAD26 props up, and RCA22 props up.
(3) adopt 5～No. 7 suture line (prolene suture of department of cardiovascular surgery, material is a prolene), near, the neutralization section far away (being divided into 3 sections) of isolated pig heart coronary artery descending anterior branch and arteria coronaria dextra according to coronary artery length respectively brokenly seam prick the coronary artery tube wall, cause in various degree narrow 1～99% stenosis rate with the coronary artery tube chamber of length, concrete stenosis rate is decided according to conventional coronarography, if ligation coronary artery tube chamber then causes entirely shutting of tube chamber to cause 100% narrow model fully.The making that every place is narrow needs about 5～10 minutes, and the ligation coronary artery was made 100% narrow need 1 minute.
Make narrow 60 places altogether, 18 places are positioned near section of LAD, and 11 places are positioned at the LAD stage casing, and 3 places are positioned at far away section of LAD; 6 places are positioned near section of RCA, and 9 places are positioned at the RCA stage casing, and 11 places are positioned at far away section of RCA.
(4) the capable above-mentioned isolated pig heart coronary artery radiography of angiocardiography machine that adopts Philips company to produce, the result is as diagnostic criteria.Use diameter 5F (1F=0.36mm) Berman foley's tube and insert LAD opening or RCA opening, capable respectively left and right coronarography, contrast machine is nonionic Ultravist370,370mgI/mL, each Medrad100 that adopts, high pressure injector produced in USA is with 5mL/s flow velocity injection 10mL, positive lateral projection.
(5) adopt electron beam computerized tomography (EBCT) scanning machine to scan above-mentioned coronary artery stenosis model, detect the accuracy of coronary artery stenosis with checking EBCT as inspection method.Concrete grammar is: with the isolated pig cardiac module be positioned over EBCT scanning bed on, with the coronarography position consistency, adopt the Single Slice Mode sequence, scanning slice thickness 1.5mm, no interlayer is every, 100 milliseconds of every tomographic image acquisition times, rebuild circle footpath 12.7cm, reconstruction matrix 512 * 512, therefore, image pixel value is 0.25 * 0.25mm
2Inject contrast preparation Ultravist370 of the same race, 370mgI/mL is diluted to 2% concentration with physiological saline, adopts the flow velocity injection 10～14mL of high pressure injector with 0.5mL/s, and finishing whole heart scanning needs 45～60 layers, scans whole heart and needs 31～42 seconds altogether.
Adopt Allegro, ISG, the medical imaging aftertreatment workstation that Canada Company produces, above-mentioned EBCT image is carried out three-dimensional reconstruction, method for reconstructing adopts maximum intensity projection method, curved surface recombination method and surface shaded explicit representation, the stenosis rate of estimation coronary artery stenosis model, result and coronarography result contrast.As Fig. 1 and Fig. 2, arrow is depicted as the narrow model of coronary artery.
Claims (1)
1, a kind of coronary artery stenosis model, it is characterized in that it is at the arteria coroaria sinistra of isolated pig heart and any position on the arteria coronaria dextra, can make the narrow model of different stenosis, different narrow positions arbitrarily, its method for making comprises the following steps:
(1) the isolated pig heart cleans and checks;
(2) adopt surgical sutures method seam to prick coronary artery or ligation coronary artery;
(3) conventional coronarography confirms narrow model;
(4) carry out the CT experimental check behind the normal saline flushing;
(5) Computer Processing image forms the three-dimensional structure image;
(6) CT 3-D view and conventional coronarography contrast.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410057396 CN1248179C (en) | 2004-08-31 | 2004-08-31 | Coronary artery stenosis model and its producing method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200410057396 CN1248179C (en) | 2004-08-31 | 2004-08-31 | Coronary artery stenosis model and its producing method |
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| Publication Number | Publication Date |
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| CN1588489A CN1588489A (en) | 2005-03-02 |
| CN1248179C true CN1248179C (en) | 2006-03-29 |
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| CN 200410057396 Expired - Fee Related CN1248179C (en) | 2004-08-31 | 2004-08-31 | Coronary artery stenosis model and its producing method |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101739880B (en) * | 2009-11-19 | 2015-01-14 | 裴秋艳 | Pretreatment method of heart of foetus |
| CN102750860A (en) * | 2012-06-22 | 2012-10-24 | 关真民 | Coronary artery stenosis demonstration model |
| JP6452715B2 (en) * | 2014-11-10 | 2019-01-16 | 国立大学法人大阪大学 | Catheter simulator and contrast method for catheter simulator |
| CN107578686A (en) * | 2016-07-05 | 2018-01-12 | 中国人民解放军第四军医大学 | A kind of preparation method of coronary artery perforation model |
| WO2018079711A1 (en) * | 2016-10-28 | 2018-05-03 | 国立大学法人大阪大学 | Organ model for catheter and/or simulator |
| CN107595348A (en) * | 2017-10-19 | 2018-01-19 | 孙晓刚 | Total aortic arch replacement and support elephant trunk technique aorta clamping device |
| CN113331848A (en) * | 2021-06-03 | 2021-09-03 | 宋培记 | Use of ultra-low contrast agents for coronary artery imaging in renal insufficiency patients |
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