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CN113974903A - Blood vessel covered stent - Google Patents

Blood vessel covered stent Download PDF

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Publication number
CN113974903A
CN113974903A CN202111432760.6A CN202111432760A CN113974903A CN 113974903 A CN113974903 A CN 113974903A CN 202111432760 A CN202111432760 A CN 202111432760A CN 113974903 A CN113974903 A CN 113974903A
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CN
China
Prior art keywords
support section
support
section
main
frame
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202111432760.6A
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Chinese (zh)
Inventor
肖颖彬
蹇朝
马瑞彦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Second Affiliated Hospital of Army Medical University
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN202111432760.6A priority Critical patent/CN113974903A/en
Publication of CN113974903A publication Critical patent/CN113974903A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/07Stent-grafts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/07Stent-grafts
    • A61F2002/072Encapsulated stents, e.g. wire or whole stent embedded in lining
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Prostheses (AREA)

Abstract

The invention belongs to the field of vascular stents, and discloses a vascular covered stent which comprises a supporting main body and a positioning end, wherein the positioning end is positioned on one end part of the supporting main body, the supporting main body comprises a supporting frame and a coating film, the coating film is covered on the inner side and/or the outer side of the supporting frame, and a plurality of outwards-expanded hollow structures are arranged on the positioning end. The aortic dissection can be well fixed.

Description

Blood vessel covered stent
Technical Field
The invention belongs to the field of vascular stents, and particularly relates to a vascular stent graft.
Background
Standford type A aortic dissection, particularly in cases where the laceration is near the aortic valve, is one of the most complicated and risky diseases of cardiovascular surgery. The current main stream mode is surgical aortic replacement, but the surgical operation has the problems of more anastomotic stoma, longer cardiac arrest time, larger damage to patients and the like in the process.
The interventional method has the advantages of small trauma, short operation time, small damage to patients and the like, and is an ideal treatment scheme compared with surgical replacement, but the currently clinically used interventional stent can only be suitable for the Standford B type aortic dissection.
Some researchers have proposed some intervention solutions, and hopefully, the difficult problem of interventional therapy of the type a interlayer can be solved, but the existing solutions are difficult to achieve a good treatment effect.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide a vascular covered stent which can better fix an aortic dissection.
The technical scheme is as follows:
the blood vessel covered stent comprises a supporting main body and a positioning end, wherein the positioning end is located on one end of the supporting main body, the supporting main body comprises a supporting frame and a coating film, the coating film is covered on the inner side and/or the outer side of the supporting frame, and a plurality of outwards-expanded hollow structures are arranged on the positioning end.
In one embodiment, the support body comprises a main lifting support section and an arch support section, the diameter of the arch support section being larger than the diameter of the main lifting support section.
In one embodiment, the bow support section is provided with a window, and the surface of the window is not covered by the coating film.
In one embodiment, the window has a width in the range of 8mm to 14mm and a length in the range of 40 to 120 mm.
In one embodiment, the raised main support section has a diameter of 20mm to 40mm, and the arch support section is 2mm to 12mm larger than the raised main support section diameter.
In one embodiment, the support body further comprises a main lifting support section, the main lifting support section and the main lifting support section are respectively located at two ends of the arch support section, and the positioning end is located at an end of the main lifting support section far away from the arch support section.
In one embodiment, the diameter of the arch support section is greater than the diameter of the descending main support section.
In one embodiment, the ascending main support section and the arch support section, and the descending main support section and the arch support section are integrally connected or separately connected and overlapped at the connection position.
In one embodiment, the supporting device further comprises a connection supporting section, the connection supporting section is located between the supporting main body and the positioning end, the connection supporting section is covered with a coating film, the connection supporting section and the supporting frame both comprise frame strips, and the frame strips adopted by the connection supporting section are higher in density than the frame strips adopted by the supporting frame.
In one embodiment, the positioning end comprises the frame strip, the frame strip is arranged to elastically expand outwards, the frame strip forms a plurality of positioning pieces, and the positioning pieces are of hollow structures and are not covered by the coating film.
The technical scheme provided by the invention has the following advantages and effects:
during the use through with blood vessel covered stent through the mode of implanting transfer treat the treatment intravascular, if transfer to aortic arch portion one side on, utilize the location end location in patient's aortic sinus this moment, realize blood vessel covered stent's location for the position of implanting is more accurate, can not take place to shift in the follow-up treatment in addition, so can guarantee the effect of treatment. After the location end is fixed well the position, release the support main part again, prop open naturally after the support main part releases, will compress tightly and prop up the blood vessel, and the support main part at this moment has the cover of coating film, so the support main part compresses tightly for the coating film when compressing tightly with the blood vessel inboard, and the location end is location in the aortic sinus, so the support main part can be followed and is close to aortic sinus one side and compress tightly the blood vessel inner wall, can be applicable to the aortic dissection case of breach in aortic valve position. Because the existence of the coating film seals the interlayer laceration, and the supporting frame has the force action of outward expansion, the coating film is tightly attached to the inner wall of the blood vessel, the internal infiltration of blood is avoided, and the blood vessel with the interlayer rupture is reshaped.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and, together with the description, serve to explain the principles and effects of the invention.
Unless otherwise specified or defined, the same reference numerals in different figures refer to the same or similar features, and different reference numerals may be used for the same or similar features.
FIG. 1 is a schematic diagram of a free-state architecture of an embodiment of the present invention;
FIG. 2 is a schematic structural diagram of an embodiment of the present invention in a simulated use state;
FIG. 3 is a schematic view of the connecting structure of the positioning end and the lifting main support section according to the embodiment of the present invention;
FIG. 4 is a schematic structural view of an arch support section of an embodiment of the invention;
fig. 5 is a schematic structural diagram of a main support section according to an embodiment of the present invention.
Description of reference numerals:
10. a support body; 11. a support frame; 111. a frame bar; 12. coating a film; 13. lifting the main support section; 14. a bow support section; 141. a window; 15. lowering the main support section; 20. a positioning end; 21. positioning plates; 30. and a cross-connecting support section.
Detailed Description
In order to facilitate an understanding of the invention, specific embodiments thereof will be described in more detail below with reference to the accompanying drawings.
Unless specifically stated or otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In the case of combining the technical solutions of the present invention in a realistic scenario, all technical and scientific terms used herein may also have meanings corresponding to the purpose of achieving the technical solutions of the present invention.
As used herein, unless otherwise specified or defined, "first" and "second" … are used merely for name differentiation and do not denote any particular quantity or order.
As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items, unless specified or otherwise defined.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly secured to the other element or intervening elements may also be present; when an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present; when an element is referred to as being "mounted on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "on" another element, it can be directly on the other element or intervening elements may also be present.
As shown in fig. 1 to 3, the blood vessel stent graft includes a supporting main body 10 and a positioning end 20, the positioning end 20 is located on one end of the supporting main body 10, the supporting main body 10 includes a supporting frame 11 and a coating film 12, the coating film 12 covers the inside and/or outside of the supporting frame 11, and a plurality of hollow structures extending outward are provided on the positioning end 20.
During the use through with blood vessel covered stent through the mode of implanting transfer treat the treatment in the blood vessel, if transfer to aortic arch portion one side on, utilize location end 20 to fix a position in patient's aortic sinus this moment, realize blood vessel covered stent's location for the position of implanting is more accurate, can not take place to shift in the follow-up treatment in addition, so can guarantee the effect of treatment. After the position is fixed at positioning end 20, support main body 10 part is released again, support main body 10 part is opened naturally after releasing, will compress tightly and prop up the blood vessel, support main body this moment has the cover of coating film 12, so support main body part compresses tightly for coating film 12 when compressing tightly with the blood vessel inboard, and positioning end 20 is location in the aortic sinus, be used for fixing a position on the aortic sinus for the structure spare of fretwork promptly, so support main body 10 can be followed and is compressed tightly the blood vessel inner wall near aortic sinus one side, can be applicable to the aortic dissection case of breach in aortic valve position. Because the existence of the coating film 12 seals the interlayer laceration, and the supporting frame 11 has the force action of outward expansion, the coating film 12 is tightly attached to the inner wall of the blood vessel, the internal infiltration of blood is avoided, and the blood vessel with the interlayer rupture is reshaped.
The coating film 12 is made of an implantable polymer film, so that blood is prevented from passing through the coating film, and body rejection is not easily caused. In the present embodiment, the inner side and the outer side of the supporting frame 11 are covered by the covering film 12.
As shown in fig. 1 to 4, the support body 10 comprises a lifting main support section 13 and an arch support section 14, the diameter of the arch support section 14 being larger than the diameter of the lifting main support section 13. Since a branch of the blood vessel exists at the aortic arch position as shown in fig. 2, blood is likely to enter between the supporting body 10 and the inner wall of the blood vessel, so that the diameter of the arch supporting section 14 is set large to ensure sufficient pressure force and prevent blood infiltration.
Specifically, as shown in fig. 1 and 4, a window 141 is disposed on the arch support section 14, and the surface of the window 141 is not covered by the coating film 12. The window 141 is free of the cover film 12, so that the blood can normally flow to the branch position.
And the window 141 has a width ranging from 8mm to 14mm and a length ranging from 40 to 120 mm. Because of the difference in vessel size between different people, a range value is set, and an appropriate window 141 size is selected according to the patient's specific situation.
Wherein the diameter of the lifting main support section 13 is 20mm to 40mm, and the arch support section 14 is 2mm to 12mm larger than the diameter of the lifting main support section 13. Similarly, an appropriate size of the main support section 13 is selected according to the specific condition of the patient. The diameter of the arch support section 14 is set according to the diameter of the main lifting support section 13. Specifically, the diameter of the main lifting support section 13 is 20mm, 22mm, 24mm, 26mm, 28mm, 30mm, 32mm, 34mm, 36mm, 38mm, 40mm, accordingly, when the diameter of the main lifting support section is 20mm to 24mm, the diameter of the arch support section 14 is 4mm larger than that of the main lifting support section, when the diameter of the main lifting support section reaches 36mm to 40mm, the diameter of the arch support section 14 is 10mm larger than that of the main lifting support section, which is just an example, and the diameters of the main lifting support section and the arch support section 14 are also adjusted appropriately according to the age, the hardening degree and other factors of the blood vessel of the patient in specific use.
As shown in fig. 1, 2 and 5, the support body 10 further includes a main descending support section 15, the main ascending support section 13 and the main descending support section 15 are respectively located at two ends of the arch support section 14, and the positioning end 20 is located at an end of the main ascending support section 13 far away from the arch support section 14. For better coverage of the aortic vessel due to its longer length, a descending main support section 15 is also provided for supporting the vessel.
As shown in fig. 1, the diameter of the arch support section 14 is larger than the diameter of the descending main support section 15. The arrangement is the same as the principle of lifting the main support section 13, and ensures that the arch support section 14 can be tightly close to the inner wall of the blood vessel, thereby preventing the blood from infiltrating. The length of the main descending support section 15 is 30 mm-180 mm, so that the length of the blood vessel can be covered as far as possible, and the blood vessel is suitable for different dissections, and is selected according to the condition of a patient.
As shown in fig. 1 to 3, the blood vessel stent graft further includes a connection supporting section 30, the connection supporting section 30 is located between the supporting body 10 and the positioning end 20, the connection supporting section 30 is covered with the covering film 12, both the connection supporting section 30 and the supporting frame 11 include frame strips 111, and the frame strips 111 adopted by the connection supporting section 30 have a higher density than the frame strips 111 adopted by the supporting frame 11. Wherein the frame strips 111 employed herein serve to provide a frame for the interface support section 30 and the support body 10 and provide corresponding outwardly extending spring forces. The frame strips 111 of the connecting and supporting section 30 have a higher density, so that the outward expansion elastic force provided by the connecting and supporting section is larger, namely, the connecting and supporting section has a larger radial supporting force, and can act together with the positioning end 20 to better fix the blood vessel covered stent. And the denser frame strip 111 can ensure that the part of support presses the coating film 12 to the native blood vessel with good fitting degree, thereby reducing the risk of blood infiltration.
The positioning end 20 comprises the frame strip 111, the frame strip 111 is arranged to elastically expand outwards, the frame strip 111 forms a plurality of positioning pieces 21, and the positioning pieces 21 are hollow structures and are not covered by the coating film 12. The spacer 21 of this moment is promptly play the positioning action, because this location end 20, outwards expand, after transplanting the human blood vessel, the spacer 21 can be arranged in patient's aorta sinus, and the spacer 21 of this moment is three, just fixes a position three arteria carotis sinuses in, because the spacer 21 expands outward and fretwork does not have coating film 12, so when not influencing sinus coronary artery opening blood flow, through the radial support to the sinus, can realize accurate positioning and the assistance-fixing of blood vessel tectorial membrane support.
Specifically, the frame bar 111 is made of a metal material, in this embodiment, a nitinol wire is used, and the positioning end 20 and the supporting frame 11 are formed by knitting and shaping, where the nitinol wire of the supporting frame 11 is configured to be connected in a W-shaped wave ring.
In this embodiment, the rising main support section 13 and the arch support section 14, and the falling main support section 15 and the arch support section 14 are integrally connected, so that there is no connection place, and the problem of infiltration of the connection is not considered. In other embodiments, the ascending main support section 13 and the arch support section 14, and the descending main support section 15 and the arch support section 14 are separately disposed and are connected at their junctions with each other. This arrangement can be changed in a flexible manner and removed when the main support section 15 does not need to be lowered, or removed when the arch support section 14 is not needed, making it more flexible to use.
It should be noted that, for the sake of clarity, the supporting frame 11 is shown, so that the portion covered by the covering film 12 is also shown as a frame bar 111, wherein the position of the edge is shown as the covering film 12, as shown in fig. 1.
When the drawing description is quoted, the new characteristics are explained; in order to avoid that repeated reference to the drawings results in an insufficiently concise description, the drawings are not referred to one by one in the case of clear description of the already described features.
The above embodiments are provided to illustrate, reproduce and deduce the technical solutions of the present invention, and to fully describe the technical solutions, the objects and the effects of the present invention, so as to make the public more thoroughly and comprehensively understand the disclosure of the present invention, and not to limit the protection scope of the present invention.
The above examples are not intended to be exhaustive of the invention and there may be many other embodiments not listed. Any alterations and modifications without departing from the spirit of the invention are within the scope of the invention.

Claims (10)

1.血管覆膜支架,其特征在于,包括支撑主体和定位端,所述定位端位于所述支撑主体的其中一个端部上,所述支撑主体包括支撑框架和包覆膜,所述包覆膜覆盖在所述支撑框架内侧和/或外侧,所述定位端上设置有多个向外扩展的镂空结构。1. A stent graft for blood vessels, characterized in that it comprises a support body and a positioning end, the positioning end is located on one end of the support body, the support body comprises a support frame and a coating film, the coating The membrane is covered on the inner side and/or the outer side of the support frame, and a plurality of outwardly expanding hollow structures are arranged on the positioning end. 2.如权利要求1所述血管覆膜支架,其特征在于,所述支撑主体包括升主支撑段和弓部支撑段,所述弓部支撑段的直径比所述升主支撑段的直径大。2 . The stent graft according to claim 1 , wherein the support body comprises an ascending main support section and an arcuate support section, and the diameter of the arcuate support section is larger than that of the ascending main support section. 3 . . 3.如权利要求2所述血管覆膜支架、其特征在于,所述弓部支撑段上设置有窗口,所述窗口表面无所述包覆膜覆盖。3 . The stent-graft according to claim 2 , wherein a window is provided on the support segment of the arcuate portion, and the surface of the window is not covered by the coating film. 4 . 4.如权利要求3所述血管覆膜支架,其特征在于,所述窗口的宽度范围为8mm至14mm,长度范围为40至120mm。4 . The stent graft according to claim 3 , wherein the window has a width ranging from 8 mm to 14 mm and a length ranging from 40 mm to 120 mm. 5 . 5.如权利要求2所述血管覆膜支架,其特征在于,所述升主支撑段的直径为20mm至40mm,所述弓部支撑段比所述升主支撑段直径大2mm至12mm。5 . The stent graft according to claim 2 , wherein the diameter of the ascending main support section is 20 mm to 40 mm, and the diameter of the arcuate support section is 2 mm to 12 mm larger than the diameter of the ascending main support section. 6 . 6.如权利要求2所述血管覆膜支架,其特征在于,所述支撑主体还包括降主支撑段,所述升主支撑段和降主支撑段分别位于所述弓部支撑段的两端部,所述定位端位于所述升主支撑段的远离所述弓部支撑段的端部。6 . The stent graft according to claim 2 , wherein the supporting body further comprises a descending main supporting section, and the ascending main supporting section and the descending main supporting section are respectively located at both ends of the arcuate supporting section. 7 . The positioning end is located at the end of the main support section that is remote from the bow support section. 7.如权利要求6所述血管覆膜支架,其特征在于,所述弓部支撑段的直径比所述降主支撑段的直径大。7 . The stent-graft of claim 6 , wherein the diameter of the arcuate support section is larger than the diameter of the descending main support section. 8 . 8.如权利要求6所述血管覆膜支架,其特征在于,所述升主支撑段和所述弓部支撑段,以及所述降主支撑段和所述弓部支撑段之间为一体连接,或是分开设置,在连接处相重叠连接。8. The stent graft according to claim 6, wherein the ascending main support section and the arcuate support section, and the descending main support section and the arcuate support section are integrally connected , or separately, overlapping connections at the connection. 9.如权利要求1至8任一项所述血管覆膜支架,其特征在于,还包括交接支撑段,所述交接支撑段位于所述支撑主体和所述定位端之间,所述交接支撑段覆盖有包覆膜,所述交接支撑段和所述支撑框架均包括框架条,所述交接支撑段采用的框架条比所述支撑框架采用的框架条密度高。9. The stent-graft according to any one of claims 1 to 8, further comprising a transition support section, the transition support section is located between the support body and the positioning end, and the transition support The segment is covered with a coating film, and both the transition support segment and the support frame include frame strips, and the frame strips used in the transition support segment have a higher density than the frame strips used in the support frame. 10.如权利要求9所述血管覆膜支架,其特征在于,所述定位端包括有所述框架条,所述框架条设置成向外弹性扩展,且所述框架条组成多个定位片,所述定位片为镂空结构且无所述包覆膜覆盖。10. The stent graft according to claim 9, wherein the positioning end comprises the frame strip, the frame strip is arranged to elastically expand outward, and the frame strip forms a plurality of positioning pieces, The positioning piece is a hollow structure and is not covered by the coating film.
CN202111432760.6A 2021-11-29 2021-11-29 Blood vessel covered stent Pending CN113974903A (en)

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