CN112354506B - Nano-emulsion preparation device of composite sterilant - Google Patents

Abstract

The invention discloses a nano-emulsion preparation device for a composite sterile agent, comprising a support frame, a compression tube, a pressurizer, an oily material tank, a water-based material tank, a spray pipe, a reaction box, and a countercurrent stirring mechanism. A compression tube with a U-shaped structure is provided. The two ports of the compression tube are provided with a pressurizer fixed to the support frame, which can pulse pressure into the compression tube. The side wall of the parallel section on one side of the compression tube is provided with oily material The side wall of the parallel section on the other side of the compression pipe is provided with a water-based material tank, the side wall of the curved section of the compression pipe is connected with a spray pipe through a pipe joint, and the free end of the spray pipe is fixed with a support frame. The reaction box is equipped with a countercurrent stirring mechanism; the application is reasonable in design, simple in operation, high in production efficiency, and the prepared nanoemulsion is not easy to layer, settle, flocculate or aggregate, and has good stability, and the application prospect is very considerable.

Description

A kind of nanoemulsion preparation device of composite sterile agent

technical field

The invention relates to the technical field of nanoemulsion production, in particular to a nanoemulsion preparation device of a composite sterile agent.

Background technique

As one of the world's biological disasters, rodent damage has caused huge economic losses to agriculture, animal husbandry and forestry. Effective control of rodent damage is a key link to ensure the sustainable development of agriculture, forestry and animal husbandry; due to the environmental pollution caused by traditional rodent control measures and animal welfare issues have attracted increasing attention; therefore, new methods must be adopted to control rodent infestation, and sterile control is considered as one of the potential options; while plant-derived sterile agents are mainly plant-derived due to their active ingredients. Secondary metabolites, which do not pollute the environment, and are not easy to cause drug resistance in rodents, have become the object of research by many scholars; in the 1980s, plant-derived sterile agents have been used in rodent control.

The main components of the plant-derived compound sterile agent ND-1, shikonin and ethinyl estradiol, are poorly water-soluble drugs, which lead to low oral bioavailability due to their poor water solubility; they cannot be effectively transported to the required tissues and body systems. play its role; nanotechnology, which emerged in the late 1980s, has the potential to solve this problem; nanoemulsions prepared by nanotechnology are isotropic dispersions of two immiscible liquids; they are composed of oil dispersed in an aqueous system. systems or aqueous systems dispersed in oily systems; unlike microemulsions, nanoemulsions are thermodynamically unstable; nanoemulsions offer multiple benefits compared to conventional botanical formulations, including improved drug permeability, Solubility, Bioavailability, Therapeutic Activity, Stability.

In the research, an ultrasonic cell pulverizer was used, and the ultrasonic emulsification method was used. This method has low energy consumption, low pollution, and is easy to operate. However, the disadvantage of this method is that the produced nanoemulsion is easy to stratify, settle, flocculate or aggregate, and has poor stability. , which will eventually lead to system instability over time, eventually leading to irreversible phase separation.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide a nanoemulsion preparation device of a composite sterile agent, which has reasonable design, simple operation, high production efficiency, the prepared nanoemulsion is not easy to layer, settles, flocculates or aggregates, has good stability, and can effectively solve the above-mentioned problems. Issues raised in the background art.

The technical scheme adopted in the present invention is as follows: a nano-emulsion preparation device for composite sterile agent, comprising a support frame, a compression tube, a pressurizer, an oily material tank, a water-based material tank, a spray pipe, a reaction box, and a countercurrent stirring mechanism. The support frame is provided with a compression tube with a U-shaped structure, and the two ports of the compression tube are provided with a pressurizer fixed to the support frame, which can pulse pressure into the compression tube. One side of the compression tube is parallel to the side wall of the section. There is an oily material tank, the other side of the parallel section of the compression pipe is provided with a water-based material tank, the side wall of the curved section of the compression pipe is connected with a spray pipe through a pipe joint, and the free end of the spray pipe is provided with The reaction box fixed with the support frame is provided with a countercurrent stirring mechanism.

Further, the top surface of the support frame is provided with a rubber seat, and the compression tube and the pressurizer are fixed on the rubber seat through a clamp.

Further, the pressurizer includes a pipe body, a base, a biaxial motor, a crankshaft, a piston rod, a piston head, and a pressure relief valve, one port of the pipe body is connected with the compression pipe through a flange, and the other port of the pipe body One end is provided with a base, a biaxial motor is provided between the pipe bodies, the shaft end of the biaxial motor is symmetrically provided with a crankshaft located in the pipe body, the eccentric shaft of the crankshaft is provided with a piston rod, and the piston rod is provided on the eccentric shaft. The free end of the pipe body is provided with a piston head, and the side wall of the pipe body is provided with a pressure relief valve.

Further, the oily material tank includes a first conical tank, a top cover, an optical axis, a first motor, a crushing knife, a sieve plate, an elbow, a medicine pipe, an oil pipe, and a first one-way valve. The lower port of the tank is connected with the compression tube, the top surface of the first conical tank is provided with a top cover, the center of the top cover is provided with a vertical downward optical axis, and the optical axis outside the top cover is provided with a top cover. For the first motor, the optical axis on the inner side of the top cover is provided with a crushing knife, a sieve plate and an elbow in sequence from top to bottom. An oil pipe is provided under the side wall sieve plate of the first conical tank, and a first check valve is provided at the lower part of the first conical tank.

Further, the water-based material tank includes a second conical tank, an end cap, a water pipe, and a second one-way valve, the lower port of the second conical tank is connected to the compression pipe, and the top surface of the second conical pipe is An end cap is provided, the side wall of the second conical tank is provided with a water pipe, and the lower part of the second conical tank is provided with a second one-way valve.

Further, the injection pipe includes a funnel pipe, a spiral protrusion and a third one-way valve, the large diameter end of the funnel pipe is connected with the pipe joint through a flange, and the inner wall of the small diameter section of the funnel pipe is provided with a spiral protrusion , the side wall of the small diameter section of the funnel tube is provided with a third one-way valve.

Further, the reaction box includes a box body, a box cover, an impact seat, a discharge port, and a gate valve, the box body is a cylindrical cavity structure with an open top surface, and a box cover is provided on the top surface of the box body, so An impact seat is detachably installed in the relative position of the jet pipe in the box, the side wall of the box is provided with a discharge port, and the discharge port is provided with a gate valve.

Further, the countercurrent stirring mechanism includes a first rotating shaft, a hollow shaft, a first paddle, a first toothed plate, a second toothed plate, a first gear, and a second motor, and the first rotating shaft is arranged on the inner bottom surface of the reaction box , the side wall of the first rotating shaft is rotatably connected with a hollow shaft, and both the hollow shaft and the side wall of the first rotating shaft are provided with a first paddle, and the first paddle is an arc-shaped structure, wherein the first paddle is located in the first The first blade on the side wall of the rotating shaft is opposite to the bending direction of the first blade located on the side wall of the hollow shaft. The shaft end of the hollow shaft extends to the outside of the reaction box and is connected with a first toothed disc. Extending to the outside of the reaction box is connected with a second toothed plate, a first gear that is rotatably connected to the reaction box is symmetrically meshed between the first toothed plate and the second toothed plate, and the shaft end of the first shaft is provided with a reaction box. Box-fixed second motor.

Further, the countercurrent stirring mechanism includes a second rotating shaft, a second paddle, a second gear, a rack, a guide rail, a first connecting rod, a second connecting rod, and a third motor, and the second rotating shaft is arranged on the side of the reaction box. On the inner bottom surface, the side wall of the second rotating shaft is provided with a second paddle, and the second paddle is an arc-shaped structure, wherein the second paddle of the upper layer and the second paddle of the lower layer are bent in opposite directions, so The shaft end of the second rotating shaft extends to the outside of the reaction box and is connected with a second gear. The top surface is provided with a first connecting rod, the free end of the first connecting rod is provided with a second connecting rod, and the free end of the second connecting rod is connected with a third motor fixed to the reaction box.

Further, the countercurrent stirring mechanism includes a third rotating shaft, a third paddle, a third gear, a fourth gear, and a fourth motor, the third rotating shaft is symmetrically arranged on the inner bottom surface of the reaction box, and the side of the third rotating shaft is symmetrical. The wall is provided with a third paddle, the third paddle is a helical structure, and the third paddles on both sides have opposite directions of rotation, and the shaft end of the third rotating shaft extends to the outside of the reaction box and is connected with a third gear, A fourth gear is meshed between the third gears, and a fourth motor fixed to the reaction box is connected to the shaft end of the fourth gear.

The beneficial effects of the present invention are as follows: by setting the oily material tank in the present application, shikonin and ethinylestradiol can be crushed and dissolved in the edible oil quickly. Falling into the compression tube, when the pressurizer simultaneously pressurizes the compression tube, the oily mixture falling into the compression tube is fully mixed with distilled water, and then the mixed oily mixture and distilled water are washed away under the action of the change of the diameter of the injection tube. The three-way valve collided with the impact seat, realizing that the particles of the oily mixture and distilled water were fully pulverized, ensuring that the substances in the particles were fully released, and then under the action of the countercurrent stirring mechanism, the oily mixture and distilled water were quickly nanometer Emulsification, after intermittent blanking, intermittent mixing, intermittent spraying, and continuous stirring, the prepared nanoemulsion is not easy to layer, settle, flocculate or aggregate to form uniform and stable nano-emulsion particles; After the emulsification is completed, a small amount of nano-emulsified particles are drawn into cold water with a clean straw, and they are not spread in the shape of oil droplets, which improves the qualification rate. /min centrifugation for 15 minutes, no stratification, good stability; the application is reasonable in design, simple in operation, high in production efficiency, the prepared nanoemulsion is not easy to stratify, settles, flocculates or aggregates, has good stability, and has a very promising application prospect.

Description of drawings

FIG. 1 is a schematic diagram of the three-dimensional structure of the present invention.

FIG. 2 is a schematic three-dimensional structure diagram of a support frame.

FIG. 3 is a schematic three-dimensional structure diagram of a compression tube.

FIG. 4 is a schematic diagram of the three-dimensional structure of the pressurizer.

FIG. 5 is a schematic view of the front cross-sectional structure of the oily material tank.

FIG. 6 is a schematic view of the front cross-sectional structure of the water-based material tank.

FIG. 7 is a schematic view of the front cross-sectional structure of the injection pipe.

FIG. 8 is a schematic cross-sectional structural schematic diagram of the front view of the reaction box and the countercurrent stirring mechanism.

FIG. 9 is a schematic three-dimensional structure diagram of the countercurrent stirring mechanism in the first embodiment.

10 is a schematic three-dimensional structure diagram of the countercurrent stirring mechanism in the second embodiment.

11 is a schematic three-dimensional structure diagram of the countercurrent stirring mechanism in the third embodiment.

In the picture: support frame 1, rubber seat 1-1, clamp 1-2, compression pipe 2, pipe joint 2-1, pressurizer 3, pipe body 3-1, base 3-2, biaxial motor 3- 3. Crankshaft 3-4, piston rod 3-5, piston head 3-6, pressure relief valve 3-7, oily material tank 4, first conical tank 4-1, top cover 4-2, optical axis 4- 3. The first motor 4-4, the crushing knife 4-5, the sieve plate 4-6, the elbow 4-7, the medicine pipe 4-8, the oil pipe 4-9, the first one-way valve 4-10, the water-based material tank 5. The second conical tank 5-1, the end cover 5-2, the water pipe 5-3, the second one-way valve 5-4, the injection pipe 6, the funnel pipe 6-1, the spiral protrusion 6-2, the third Check valve 6-3, reaction box 7, box body 7-1, box cover 7-2, impact seat 7-3, outlet 7-4, gate valve 7-5, countercurrent stirring mechanism 8, first shaft 8 -1. Hollow shaft 8-2, first paddle 8-3, first gear plate 8-4, second gear plate 8-5, first gear 8-6, second motor 8-7, second shaft 8-8, second paddle 8-9, second gear 8-10, rack 8-11, guide rail 8-12, first link 8-13, second link 8-14, third motor 8 -15, the third shaft 8-16, the third paddle 8-17, the third gear 8-18, the fourth gear 8-19, the fourth motor 8-20.

Detailed ways

In order to make those skilled in the art better understand the technical solution of the present invention, the present invention will be further described in detail below with reference to the accompanying drawings, the following description is only used to illustrate the technical solution of the present invention and not limit it.

In the description of the present invention, it should be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", The orientation or positional relationship indicated by "top", "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying The device or element referred to must have a particular orientation, be constructed and operate in a particular orientation, and therefore should not be construed as limiting the invention; in addition, the terms "first", "second", "third", "fourth" ” etc. are only used for descriptive purposes and should not be construed to indicate or imply relative importance or to imply indicate the number of technical features indicated.

Example 1

Please refer to Figures 1-9, a nano-emulsion preparation device for composite sterile agent, including a support frame 1, a compression tube 2, a pressurizer 3, an oily material tank 4, an aqueous material tank 5, a spray pipe 6, and a reaction box 7 . The countercurrent stirring mechanism 8 is characterized in that a compression tube 2 with a U-shaped structure is installed on the support frame 1, and the two ports of the compression tube 2 are installed with a pressurizer 3 fixed with the support frame 1, which can be directed to the compression tube. 2, an oily material tank 4 is installed on the side wall of the parallel section on one side of the compression pipe 2, and a water-based material tank 5 is installed on the side wall of the parallel section on the other side of the compression pipe 2. The side wall of the curved segment of .

In the present invention, the top surface of the support frame 1 is fixed with a rubber seat 1-1 by bolts, and the compression tube 2 and the pressurizer 3 are fixed on the rubber seat 1-1 by a clamp 1-2, which reduces the shock effect.

In the present invention, the pressurizer 3 includes a pipe body 3-1, a base 3-2, a biaxial motor 3-3, a crankshaft 3-4, a piston rod 3-5, a piston head 3-6, and a pressure relief valve 3 -7, one port of the pipe body 3-1 is connected with the compression pipe 2 through a flange, the other end of the pipe body 3-1 is installed with a base 3-2, and the pipe body 3-1 is between the A biaxial motor 3-3 is installed, the shaft end of the biaxial motor 3-3 is symmetrically installed with a crankshaft 3-4 located in the pipe body 3-1, and a piston rod is hinged on the eccentric shaft of the crankshaft 3-4 3-5, the free end of the piston rod 3-5 is hinged with a piston head 3-6, and a pressure relief valve 3-7 is installed on the side wall of the pipe body 3-1.

In the present invention, the oily material tank 4 includes a first conical tank 4-1, a top cover 4-2, an optical axis 4-3, a first motor 4-4, a crushing knife 4-5, and a sieve plate 4-6 , elbow 4-7, medicine pipe 4-8, oil pipe 4-9, first one-way valve 4-10, the lower port of the first conical tank 4-1 is connected with the compression pipe 2, the first The top surface of the conical tank 4-1 is fixed with a top cover 4-2 by bolts, and the center of the top cover 4-2 is rotatably connected with a vertically downward optical axis 4-3. A first motor 4-4 is installed on the optical axis 4-3, and a crushing knife 4-5, a sieve plate 4-6, and a curved pipe are fixed on the optical axis 4-3 inside the top cover 4-2 in order from top to bottom. 4-7, a medicine tube 4-8 is welded between the side wall sieve plate 4-6 of the first conical tank 4-1 and the top cover 4-2, the side of the first conical tank 4-1 is An oil pipe 4-9 is welded under the wall sieve plate 4-6, and a first check valve 4-10 is installed at the lower part of the first conical tank 4-1.

In the present invention, the water-based material tank 5 includes a second conical tank 5-1, an end cover 5-2, a water pipe 5-3, and a second one-way valve 5-4. The second conical tank 5-1 The lower port of the second conical tank is connected with the compression pipe 2, the top surface of the second conical pipe is fixed with an end cover 5-2 by bolts, and the side wall of the second conical tank 5-1 is welded with a water pipe 5-3, so A second check valve 5-4 is installed at the lower part of the second conical tank 5-1.

In the present invention, the injection pipe 6 includes a funnel pipe 6-1, a spiral protrusion 6-2, and a third one-way valve 6-3, and the large diameter end of the funnel pipe 6-1 passes through the pipe joint 2-1 Flange connection, the inner wall of the small diameter section of the funnel tube 6-1 is welded with a spiral protrusion 6-2, and the side wall of the small diameter section of the funnel tube 6-1 is installed with a third one-way valve 6-3.

In the present invention, the reaction box 7 includes a box body 7-1, a box cover 7-2, an impact seat 7-3, a discharge port 7-4, and a gate valve 7-5, and the box body 7-1 is the top surface Open cylindrical cavity structure, the top surface of the box body 7-1 is fixed with a box cover 7-2 by bolts, and the relative position of the injection pipe 6 in the box body 7-1 is detachably installed with an impact seat 7-3 , a discharge port 7-4 is welded on the side wall of the box body 7-1, and a gate valve 7-5 is installed on the discharge port 7-4.

In the present invention, the countercurrent stirring mechanism 8 includes a first rotating shaft 8-1, a hollow shaft 8-2, a first paddle 8-3, a first toothed disc 8-4, a second toothed disc 8-5, a first toothed disc 8-5, The gear 8-6, the second motor 8-7, the first rotating shaft 8-1 is arranged on the inner bottom surface of the reaction box 7, the side wall of the first rotating shaft 8-1 is rotatably connected with a hollow shaft 8-2, and The side walls of the hollow shaft 8-2 and the first rotating shaft 8-1 are welded with a first paddle 8-3, and the first paddle 8-3 is a cambered structure, wherein the first paddle 8-3 is located on the first rotating shaft 8-1. The first paddle 8-3 of the side wall is opposite to the bending direction of the first paddle 8-3 located on the side wall of the hollow shaft 8-2, and the shaft end of the hollow shaft 8-2 extends to the outside of the reaction box 7 and is connected to the A toothed plate 8-4, the shaft end of the first rotating shaft 8-1 extends to the outside of the reaction box 7 and is connected with a second toothed plate 8-5, the first toothed plate 8-4 and the second toothed plate 8- 5 is symmetrically meshed with a first gear 8-6 rotatably connected to the reaction box 7, the shaft end of the first rotating shaft 8-1 is installed with a second motor 8-7 fixed with the reaction box 7, stirring process: start The second motor 8-7 drives the first paddle 8-3 on the side wall of the first rotating shaft 8-1 to rotate, the first rotating shaft 8-1 drives the second toothed plate 8-5 to rotate synchronously, and the second toothed plate 8- 5. Drive the first gear 8-6 to rotate, the first gear 8-6 drives the first toothed disc 8-4 to rotate, and the first toothed disc 8-4 drives the first paddle 8-3 of the side wall of the hollow shaft 8-2 to synchronize Rotation realizes the countercurrent stirring of oily material and water-based material.

Embodiment 2

Please refer to FIG. 8 and FIG. 10 , the rest of the structure is the same as that of the first embodiment. The counter-current stirring mechanism 8 may also be that the counter-current stirring mechanism 8 includes a second rotating shaft 8-8, a second paddle 8-9, a second Gear 8-10, rack 8-11, guide rail 8-12, first connecting rod 8-13, second connecting rod 8-14, third motor 8-15, the second rotating shaft 8-8 is set in the reaction The inner bottom surface of the box 7, the side wall of the second rotating shaft 8-8 is welded with a second paddle 8-9, and the second paddle 8-9 is a cambered structure, wherein the upper second paddle 8-9 is opposite to the bending direction of the lower second paddle 8-9, the shaft end of the second rotating shaft 8-8 extends to the outside of the reaction box 7 and is connected with a second gear 8-10, and the guide rail 8-12 is provided with a second gear 8-10. On the outer side wall of the reaction box 7, the guide rail 8-12 is slidably connected with a rack 8-11 adapted to the gear, and a first link 8-13 is hinged on one end top surface of the rack 8-11. The free end of the first connecting rod 8-13 is hinged with a second connecting rod 8-14, and the free end of the second connecting rod 8-14 is connected with a third motor 8-15 fixed with the reaction box 7, stirring Process: start the third motor 8-15, drive the second link 8-14 to rotate, the second link 8-14 drives the first link 8-13 to swing, so that the rack 8-11 makes a straight line along the guide rail 8-12 In the reciprocating motion, the rack 8-11 drives the second gear 8-10 to rotate forward and reverse, so that the second paddle 8-9 synchronizes forward and reverse rotation, and realizes the countercurrent stirring of the oily material and the water-based material.

Embodiment 3

Please refer to FIG. 8 and FIG. 11 , the rest of the structure is the same as that of the first embodiment. The counter-current stirring mechanism 8 may also be that the counter-current stirring mechanism 8 includes a third rotating shaft 8-16, a third paddle 8-17, a third Gear 8-18, fourth gear 8-19, fourth motor 8-20, the third rotating shaft 8-16 is symmetrically arranged on the inner bottom surface of the reaction box 7, and the side wall of the third rotating shaft 8-16 is provided with The third paddle 8-17, the third paddle 8-17 is a helical structure, and the third paddles 8-17 on both sides have opposite directions of rotation, and the shaft end of the third rotating shaft 8-16 extends to A third gear 8-18 is connected to the outside of the reaction box 7, a fourth gear 8-19 is meshed between the third gears 8-18, and the shaft end of the fourth gear 8-19 is connected to the reaction box 7 Fixed fourth motor 8-20, stirring process: start the fourth motor 8-20, drive the fourth gear 8-19 to rotate synchronously, the fourth gear 8-19 drives the third gear 8-18 to rotate in the opposite direction, so that the third paddle The blades 8-17 rotate in opposite directions to realize the countercurrent stirring of the oily material and the water-based material.

Working principle: The operator can first crush shikonin and ethinyl estradiol and dissolve them in the edible oil quickly. When the pressurizer 3 releases the pressure on the compression pipe 2 synchronously, the oily mixture and distilled water fall into the compression pipe 2. When the pressurizer 3 pressurizes the compression pipe 2 synchronously, the oily mixture falling into the compression pipe 2 is fully mixed with distilled water, and then the mixed oily mixture and distilled water are washed away under the action of the change of the diameter of the injection pipe 6. The one-way valve 6-3 hits the impact seat 7-3, so that the particles of the oily mixture and distilled water are fully pulverized, ensuring that the substances in the particles are fully released, and then under the action of the countercurrent stirring mechanism 8, the oily mixture is Rapid nano-emulsification of the mixture and distilled water, after intermittent blanking, intermittent mixing, intermittent spraying, and continuous stirring, the prepared nano-emulsion is not easy to stratify, settle, flocculate or aggregate to form uniform and stable nano-emulsion particles; the design of this application is reasonable, The operation is simple, the production efficiency is high, the prepared nanoemulsion is not easy to be layered, settles, flocculates or aggregates, has good stability, and has considerable application prospects.

Although the present invention has been described in detail with reference to the foregoing examples, for those skilled in the art, it is still possible to carry out and modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims (8)

1. a nanoemulsion preparation device of a composite sterile agent, comprising a support frame, a compression tube, a pressurizer, an oily material tank, a water-based material tank, a jet pipe, a reaction box, a countercurrent stirring mechanism, it is characterized in that the support frame There is a compression tube with a U-shaped structure on the top, and the two ports of the compression tube are provided with a pressurizer fixed with the support frame, which can pulse pressure into the compression tube, and the side wall of the parallel section on one side of the compression tube is provided with oil The side wall of the parallel section on the other side of the compression pipe is provided with a water-based material tank, and the side wall of the curved section of the compression pipe is connected with an injection pipe through a pipe joint, and the injection pipe includes a funnel pipe, a spiral protrusion, The third one-way valve, the large diameter end of the funnel tube and the pipe joint are connected by flanges, the inner wall of the small diameter section of the funnel tube is provided with a spiral protrusion, and the side wall of the small diameter section of the funnel tube is provided with a third Three one-way valve, the free end of the injection pipe is provided with a reaction box fixed with the support frame, the reaction box includes a box body, a box cover, an impact seat, a discharge port, and a gate valve, and the box body is open on the top surface A cylindrical cavity structure, the top surface of the box is provided with a box cover, the ejection pipe in the box is detachably installed with an impact seat at the relative position, the side wall of the box is provided with a discharge port, the outlet A gate valve is arranged on the material port, and a countercurrent stirring mechanism is arranged in the reaction box. 2. The nanoemulsion preparation device of a composite sterile agent according to claim 1, characterized in that the top surface of the support frame is provided with a rubber seat, and the compression tube and the pressurizer are fixed on the rubber through a clamp seat. 3. The nanoemulsion preparation device of a composite sterile agent according to claim 1, wherein the pressurizer comprises a pipe body, a base, a biaxial motor, a crankshaft, a piston rod, a piston head, a pressure relief valve , one port of the tube body is connected with the compression tube through a flange, the other end of the tube body is provided with a base, a biaxial motor is arranged between the tube bodies, and the shaft ends of the biaxial motor are symmetrically provided with The crankshaft is located in the pipe body, the eccentric shaft of the crankshaft is provided with a piston rod, the free end of the piston rod is provided with a piston head, and the side wall of the pipe body is provided with a pressure relief valve. 4. The nanoemulsion preparation device of a composite sterile agent according to claim 1, wherein the oily material tank comprises a first conical tank, a top cover, an optical axis, a first motor, a crushing knife, a sieve plate, elbow, medicine pipe, oil pipe, first one-way valve, the lower port of the first conical tank is connected with the compression pipe, the top surface of the first conical tank is provided with a top cover, the top cover The center is provided with a vertical downward optical axis, wherein the optical axis on the outside of the top cover is provided with a first motor, and the optical axis on the inner side of the top cover is provided with a crushing knife, a sieve plate, and a curved pipe in sequence from top to bottom. A medicine pipe is arranged between the side wall sieve plate and the top cover of the first conical tank, an oil pipe is arranged under the side wall sieve plate of the first conical tank, and the lower part of the first conical tank is provided with an oil pipe. The first one-way valve. 5. The nanoemulsion preparation device of a composite sterile agent according to claim 1, wherein the water-based material tank comprises a second conical tank, an end cap, a water pipe, and a second one-way valve, and the first The lower port of the second conical tank is connected with the compression pipe, the top surface of the second conical pipe is provided with an end cover, the side wall of the second conical tank is provided with a water pipe, and the lower part of the second conical tank is provided with an end cap. A second one-way valve is provided. 6. The nanoemulsion preparation device of a composite sterile agent according to claim 1, wherein the countercurrent stirring mechanism comprises a first rotating shaft, a hollow shaft, a first paddle, a first toothed disc, a second toothed The disk, the first gear and the second motor, the first rotating shaft is arranged on the inner bottom surface of the reaction box, the side wall of the first rotating shaft is rotatably connected with a hollow shaft, and the hollow shaft and the side wall of the first rotating shaft are provided with The first paddle, the first paddle has a cambered structure, wherein the first paddle located on the side wall of the first rotating shaft is opposite to the bending direction of the first paddle located on the side wall of the hollow shaft. The shaft end extends to the outside of the reaction box and is connected with a first toothed plate, the shaft end of the first rotating shaft extends to the outside of the reaction box and is connected with a second toothed plate, and the first toothed plate and the second toothed plate are symmetrically engaged with each other. The first gear is rotatably connected with the reaction box, and the shaft end of the first rotating shaft is provided with a second motor fixed with the reaction box. 7. The nanoemulsion preparation device of a composite sterile agent according to claim 1, wherein the countercurrent stirring mechanism comprises a second rotating shaft, a second paddle, a second gear, a rack, a guide rail, a first A connecting rod, a second connecting rod, and a third motor, the second rotating shaft is provided on the inner bottom surface of the reaction box, the side wall of the second rotating shaft is provided with a second paddle, and the second paddle is cambered structure, wherein the bending direction of the second blade of the upper layer is opposite to that of the second blade of the lower layer, the shaft end of the second shaft extends to the outside of the reaction box and is connected with a second gear, and the guide rail is provided on the outer side wall of the reaction box , the guide rail is slidably connected with a rack adapted to the gear, one end of the rack is provided with a first connecting rod, the free end of the first connecting rod is provided with a second connecting rod, and the first connecting rod is provided with a second connecting rod. The free end of the second connecting rod is connected with a third motor fixed with the reaction box. 8. The nanoemulsion preparation device of a composite sterile agent according to claim 1, wherein the countercurrent stirring mechanism comprises a third rotating shaft, a third paddle, a third gear, a fourth gear, and a fourth motor , the third rotating shaft is symmetrically arranged on the inner bottom surface of the reaction box, the side wall of the third rotating shaft is provided with a third paddle, the third paddle is a helical structure, and the third paddles on both sides rotate On the contrary, the shaft end of the third rotating shaft extends to the outside of the reaction box and is connected with a third gear, a fourth gear is meshed between the third gears, and the shaft end of the fourth gear is connected with the reaction box. Fourth motor.

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