CN111905037A

CN111905037A - Nursing composition, nursing product and preparation method thereof

Info

Publication number: CN111905037A
Application number: CN202010814907.7A
Authority: CN
Inventors: 朱军; 王磊; 谢水林; 孟丽; 陈凤鸾; 聂舟; 王晓慧
Original assignee: Guangzhou Rui Sen Biotechnology Co ltd
Current assignee: Guangzhou Rui Sen Biotechnology Co ltd
Priority date: 2020-08-13
Filing date: 2020-08-13
Publication date: 2020-11-10

Abstract

The invention discloses a nursing composition, a nursing product and a preparation method thereof, and belongs to the technical field of female nursing products. The care composition includes plant extracts including coconut extract, soybean extract and epimedium extract. The nursing composition can nourish yin and improve vaginal relaxation by compounding the coconut extract, the soybean extract and the epimedium extract, and can also appropriately supplement estrogen in a human body, regulate endocrine in the human body and keep the private part compact and moist. The nursing product containing the nursing composition can improve vaginal relaxation, regulate hormone in vivo, maintain flora balance, increase vaginal lubrication, and has bactericidal effect. The preparation method has the advantages of simple process, low production cost, low energy consumption and easy realization of industrial production.

Description

Nursing composition, nursing product and preparation method thereof

Technical Field

The invention relates to the technical field of female care products, and particularly relates to a care composition, a care product and a preparation method thereof.

Background

As is known, the female genital tract is an open cavity tract, and is a micro-ecosystem mainly composed of dominant bacteria, and in daily life, women suffer from gynecological inflammation to different degrees, and the gynecological inflammation is frequently caused by: the female has unbalanced vaginal microecology and poor vaginal relaxation elasticity, and is easy to be infected by the outside; atrophy or secretion function disorder of vaginal glands, vaginal dryness, internal acid-base imbalance, vaginal self-cleaning and barrier function loss; and do not pay attention to personal hygiene, etc. Women's gynecological inflammation is frequent, which can cause endocrine dyscrasia, lackluster and easy to generate color spots, involuntary confidence, irritability and easy premature senility, and make women suffer great harm. Meanwhile, with the increase of age, the organs of the human body are aged gradually, the ovarian function is reduced gradually, the estrogen level is reduced, the secretion capacity of the human body is weakened, and the vagina is dry and astringent and loses elasticity; meanwhile, various physiological processes mediated by estrogen are affected, and physiological and psychological symptoms such as palpitation, chest distress, anxiety, depression, easy excitation, insomnia, hypomnesis and the like are generated.

Most of the existing private care products are bacteriostatic and bactericidal products, which cannot fundamentally repair muscles and ligaments around the vagina, cannot perform a good tightening effect on the vagina and cannot regulate in-vivo hormones, and in addition, part of the products are improper to use, which easily causes double infection or drug resistance of bacteria, causes imbalance of flora in the vagina and low immunity of the vagina, so that inflammation is repeatedly attacked and cannot be radically cured.

In view of this, the invention is particularly proposed.

Disclosure of Invention

One of the purposes of the invention is to provide a nursing composition which can nourish the vagina and improve vaginal relaxation, and also can appropriately supplement estrogen in the human body, regulate the internal secretion of the human body and keep the tight and moist of the private parts.

The second purpose of the invention is to provide a nursing product which not only can improve vaginal relaxation and regulate hormone in vivo, maintain flora balance, increase vaginal lubrication, but also has the efficacy of sterilization.

The invention also aims to provide a preparation method of the nursing product, which has the advantages of simple process, low production cost, low energy consumption and easy realization of industrial production.

The invention is realized by the following steps:

in a first aspect, the present application provides a care composition comprising a plant extract including coconut extract, soybean extract, and epimedium extract.

In an alternative embodiment, the care composition further comprises at least one of aloe vera extract and safflower extract.

In a preferred embodiment, the coconut extract is a cherry tomato extract.

In an alternative embodiment, the weight ratio of aloe vera extract to cherry tomato extract is 1-3: 1-4.

In an alternative embodiment, the weight ratio of safflower extract to cherry tomato extract is 0.5-2: 1-4.

In an alternative embodiment, the weight ratio of epimedium extract to cherry tomato extract is 0.5-1: 1-4.

In an alternative embodiment, the weight ratio of soy extract to cherry tomato extract is 0.1-0.5: 1-4.

In a second aspect, the present application provides a treatment product whose starting materials comprise a treatment composition as described previously.

In an alternative embodiment, the ingredients of the care product further comprise at least one of a thickening agent, a neutralizing agent, a humectant, a solvent, a solubilizer, a bactericide, a cooling agent, a pH adjuster, and a pH buffer.

In an alternative embodiment, the thickener comprises at least one of hydroxyethyl cellulose, methyl hydroxyethyl cellulose, and methyl cellulose.

In alternative embodiments, the neutralizing agent comprises at least one of triethanolamine, arginine, and aminomethyl propanol.

In an alternative embodiment, the humectant comprises at least one of glycerin, propylene glycol, butylene glycol, and sodium 1,3 propanediol hyaluronate.

In an alternative embodiment, the solvent is ethanol.

In an alternative embodiment, the antimicrobial agent comprises at least one of chlorhexidine acetate, chlorhexidine digluconate, chlorhexidine dihydrochloride, and chlorhexidine diacetate.

In an alternative embodiment, the cooling agent comprises at least one of menthol and menthol.

In an alternative embodiment, the solubilizing agent comprises at least one of PPG-26-Butaneth-26/PEG-40 hydrogenated castor oil, PPG-12-Butaneth-12, PEG-20 hydrogenated castor oil, PEG-30 hydrogenated castor oil, and PEG-60 hydrogenated castor oil.

In alternative embodiments, the pH adjusting agent comprises at least one of lactic acid, lactobionic acid and citric acid.

In an alternative embodiment, the pH buffering agent is sodium citrate.

In an alternative embodiment, the raw materials comprise, by weight, 1-2.5% of hydroxyethyl cellulose, 1-2% of triethanolamine, 3-8% of glycerol, 3-8% of ethanol, 0.1-0.5% of chlorhexidine acetate, 0.01-0.1% of menthol, 1-3% of PPG-26-buteth-26/PEG-40 hydrogenated castor oil, 0.5-2.5% of lactic acid, 0.1-1% of sodium citrate, 0.05-0.3% of sodium hyaluronate, and 2-15% of plant extract, with the balance being water.

In an alternative embodiment, the raw materials comprise, by weight, 1.5-2% of hydroxyethyl cellulose, 1-2% of triethanolamine, 3-6% of glycerol, 3-6% of ethanol, 0.1-0.3% of chlorhexidine acetate, 0.01-0.08% of menthol, 1-3% of PPG-26-butyether-26/PEG-40 hydrogenated castor oil, 1-2.5% of lactic acid, 0.3-1% of sodium citrate, 0.05-0.2% of sodium hyaluronate, and 3-15% of plant extract, with the balance being water.

In a third aspect, the present application provides a method of making a care product as described above, comprising the steps of: mixing the raw materials.

In an alternative embodiment, when the starting materials include hydroxyethylcellulose, triethanolamine, glycerol, ethanol, chlorhexidine acetate, menthol, PPG-26-butyether-26/PEG-40 hydrogenated castor oil, lactic acid, sodium citrate, sodium hyaluronate, and plant extracts, the following steps are followed: mixing glycerol, ethanol, chlorhexidine acetate, Mentholum, PPG-26-Butanol polyether-26/PEG-40 hydrogenated castor oil to obtain a first mixed solution.

And mixing hydroxyethyl cellulose, triethanolamine and water to obtain a second mixed solution.

And mixing the second mixed solution with sodium citrate, lactic acid, sodium hyaluronate and plant extract to obtain a third mixed solution.

And mixing the first mixed solution and the third mixed solution.

In an alternative embodiment, the second mixture is prepared by first mixing the hydroxyethyl cellulose with water and then mixing it with triethanolamine.

In an alternative embodiment, the mixing of the hydroxyethylcellulose with water is carried out at a temperature of 80-85 ℃.

In an alternative embodiment, the second mixed solution is prepared at a stirring speed of 80 to 150 rpm.

In an alternative embodiment, the aqueous solution of hydroxyethyl cellulose mixed with triethanolamine is incubated for 20-30 min.

In an alternative embodiment, the second mixed solution is mixed with the sodium citrate, the lactic acid, and then the sodium hyaluronate and the plant extract in sequence.

In an alternative embodiment, when the plant extracts include both the cherry tomato extract, the aloe vera extract, the safflower extract, the epimedium extract and the soybean extract, the second mixture is mixed with sodium citrate and lactic acid and then sequentially mixed with sodium hyaluronate, the cherry tomato extract, the aloe vera extract, the safflower extract, the soybean extract and the epimedium extract.

In an optional embodiment, the temperature of the second mixed solution after heat preservation is reduced to 40-45 ℃ and then the second mixed solution is mixed with sodium citrate and lactic acid.

In an alternative embodiment, the second mixture is mixed with the sodium citrate and the lactic acid by stirring at a rotation speed of 300-500rpm for 5-10 min.

The beneficial effects of the invention include:

the nursing composition provided by the application can nourish the yin and improve vaginal relaxation by compounding the coconut extract, the soybean extract and the epimedium extract, and can also appropriately supplement estrogen in a human body, regulate endocrine in the human body and keep the private parts compact and moist. The nursing product containing the nursing composition can improve vaginal relaxation, regulate hormone in vivo, maintain flora balance, increase vaginal lubrication, and has bactericidal effect. The preparation method of the nursing product has the advantages of simple process, low production cost, low energy consumption and easy realization of industrial production.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

The care compositions, care products, and methods of making the same provided herein are described in detail below.

The present application proposes a care composition comprising plant extracts including coconut extract, soybean extract and epimedium extract.

Preferably, the coconut extract is a cherry tomato extract.

The cherry tomato coconut is one of three rare plants in the world, is the only miracle plant growing on the island of the African Seityold, is rich in saponin, glucoxib, tannic acid, amino acid, fatty acid, vitamins, and trace elements such as iron, zinc, phosphorus, potassium, calcium and the like, and can be used as one of the components of the nursing composition in the application, so that the nursing composition has the effects of promoting vaginal mucosa tightening, fibrous histiocyte regeneration and the like.

It is worth noting that coconut extracts from other species of coconut have similar efficacy to cherry tomato extract, but are superior to cherry tomato extract.

The soybean extract contains soybean isoflavone as main effective component. The soybean isoflavone has molecular weight and structure similar to that of female hormone, and is called "plant female hormone". For female with high hormone, the soybean isoflavone can reduce the harm; for female hormone deficiency, soybean isoflavone can be used for relieving female hormone deficiency. In addition, soybean isoflavone is a phytohormone and has the function of estrogen, but has no side effect after the estrogen is used.

The stem and leaf of epimedium contains icariine and icariine A, the rhizome and root contain active ingredients such as noricariine and icariin, and the extract of the rhizome or stem and leaf of epimedium is adopted as one of the components of the nursing composition, so that the nursing composition has the function of regulating endocrine.

In conclusion, the coconut extract, especially the cherry tomato extract, the soybean extract and the epimedium extract are compounded, so that the coconut extract, especially the cherry tomato extract, can nourish the yin and improve vaginal relaxation, and also can appropriately supplement estrogen in a human body, regulate endocrine in the human body and keep the private parts tight and moist.

Further, the care composition provided by the present application wherein the plant extract further comprises at least one of aloe vera extract and safflower extract.

The aloe extract contains anthraquinone compounds, polysaccharides, organic acids, amino acids, vitamins, mineral elements, active enzymes and other effective components, and has effects of diminishing inflammation, sterilizing, and promoting wound healing.

The Carthami flos extract contains various effective components such as safflower glycoside, neosafflower glycoside and safflower quinone glycoside, nonacosane beta-sitosterol, palmitic acid, myristic acid, lauric acid, dipalmitin, oleic acid, linoleic acid, beta-sitosterol-3-O-glucoside, polysaccharide, etc., and has effects of promoting blood circulation, dredging channels, removing blood stasis and relieving pain.

The aloe extract and the epimedium extract both have the functions of sterilization and bacteriostasis, and after the aloe extract and the epimedium extract are compounded, the irritation and the drug resistance of the traditional bactericide can be reduced or avoided.

In alternative embodiments, the weight ratio of aloe vera extract to cherry tomato extract may be 1-3: 1-4, such as 1: 1. 2: 2.5 or 3: 4, etc.

In an alternative embodiment, the weight ratio of the safflower extract to the cherry tomato extract may be 0.5-2: 1-4, such as 0.5: 1. 1: 3. 2: 2.5 or 1.5: 4, etc.

In an alternative embodiment, the weight ratio of epimedium extract to cherry tomato extract may be 0.5-1: 1-4, such as 0.5: 1. 1: 1. 1: 2.5 or 1: 4, etc.

In alternative embodiments, the weight ratio of soy extract to cherry tomato extract may be 0.1-0.5: 1-4, such as 0.1: 1. 0.3: 1. 0.5: 2.5 or 0.5: 4, etc.

It should be noted that the above-mentioned plant extracts referred to in the present application are commercially available as they are, for example, coconut extract from Guangzhou Hongzhong, aloe extract from Orobao, safflower extract from Weike, soybean extract from Ruyu chemical, and epimedium extract from Shaanxi Tianyuan biology, Inc. In addition, the plant extract can be prepared by the related technology.

In conclusion, the nursing composition provided by the application can nourish the yin and improve vaginal relaxation, can appropriately supplement estrogen in the human body, regulate endocrine in the human body, keep the private parts compact and moist, has the effects of sterilization and bacteriostasis, and can reduce or avoid irritation and drug resistance generated by the traditional bactericide.

In addition, the application also provides a care product, and the raw material of the care product comprises the care composition.

In alternative embodiments, the ingredients of the care product may also include, but are not limited to, at least one of a thickening agent, a neutralizing agent, a humectant, a solvent, a solubilizer, a bactericide, a cooling agent, a pH adjuster, and a pH buffer.

By reference, the thickener may, for example, comprise at least one of hydroxyethylcellulose, methylhydroxyethylcellulose, and methylcellulose. The neutralizing agent may include, for example, at least one of triethanolamine, arginine, and aminomethyl propanol. The humectant can include, for example, at least one of glycerin, propylene glycol, butylene glycol, and sodium 1,3 propanediol hyaluronate. The solvent may be, for example, ethanol. The antimicrobial agent may include, for example, at least one of chlorhexidine acetate, chlorhexidine digluconate, chlorhexidine dihydrochloride, and chlorhexidine diacetate. The cooling agent may include, for example, at least one of menthol and menthol. The solubilizer may include at least one of PPG-26-Butanethol-26/PEG-40 hydrogenated castor oil, PPG-12-Butanethol-12, PEG-20 hydrogenated castor oil, PEG-30 hydrogenated castor oil, and PEG-60 hydrogenated castor oil. The pH adjusting agent may include, for example, at least one of lactic acid, lactobionic acid, and citric acid. The pH buffer may be, for example, sodium citrate.

In alternative embodiments, the starting materials for the care product may include, by weight percent, 1-2.5% (e.g., 1%, 1.5%, 2%, or 2.5%, etc.) hydroxyethyl cellulose, 1-2% (e.g., 1%, 1.5%, or 2%, etc.) triethanolamine, 3-8% (e.g., 3%, 5%, 6%, or 8%, etc.) glycerol, 3-8% (e.g., 3%, 5%, 6%, or 8%, etc.) ethanol, 0.1-0.5% (e.g., 0.1%, 0.2%, 0.3%, 0.4%, or 0.5%, etc.) chlorhexidine acetate, 0.01-0.1% (e.g., 0.01%, 0.05%, 0.08%, or 0.1%, etc.) menthol, 1-3% (e.g., 1%, 1.5%, 2%, 2.5%, or 3%, etc.) 26-butanol-polyether-26/PEG-40 hydrogenated castor oil, 0.5-2.5%, 0.5%, 1.5%, or 3%, etc., PPG, 1.5%, 2%, 2.5%, etc.) lactic acid, 0.1-1% (e.g., 0.1%, 0.3%, 0.5%, 1%, etc.) sodium citrate, 0.05-0.3% (e.g., 0.05%, 0.1%, 0.2%, 0.3%, etc.) sodium hyaluronate, and 2-15% (e.g., 2%, 3%, 5%, 8%, 10%, 15%, etc.) plant extract, with the balance being water.

Further, the raw materials of the care product can comprise 1.5-2% of hydroxyethyl cellulose, 1-2% of triethanolamine, 3-6% of glycerol, 3-6% of ethanol, 0.1-0.3% of chlorhexidine acetate, 0.01-0.08% of menthol, 1-3% of PPG-26-Butaneth-26/PEG-40 hydrogenated castor oil, 1-2.5% of lactic acid, 0.3-1% of sodium citrate, 0.05-0.2% of sodium hyaluronate, 3-15% of plant extract, and the balance of water.

The chlorhexidine acetate is mainly used for being matched with the epimedium extract and the aloe extract in the plant extract, the sterilization effect of the nursing product can be further improved, and meanwhile, the epimedium extract and the aloe extract can reduce or avoid the irritation and drug resistance generated by the chlorhexidine acetate.

The lactic acid is mainly used for balancing the weak acid state of private parts, maintaining the balance of flora in vivo, keeping the environment of vagina healthy bacteria, and simultaneously leading the chlorhexidine acetate to better exert the sterilization effect under the weak acid condition.

In addition, in the present care product, hydroxyethyl cellulose acts primarily as a thickener, triethanolamine acts primarily as a neutralizer (i.e., a pH adjuster), glycerin is a humectant, ethanol is a solvent (primarily for chlorhexidine acetate and menthol), PPG-26-buteth-26/PEG-40 hydrogenated castor oil acts primarily as a solubilizer, menthol acts primarily as a soothing cooling, and sodium citrate is a pH buffer.

Bearing in, the nursing product formula that this application provided is compatible reasonable, and each component harmony is good, through coordinating the raw materials according to specific proportion for the nursing product has good effects such as disinfect and tighten, maintain bacterial colony balance and adjust hormone in vivo. This nursing product is safe not to have the stimulation, can not produce drug resistance and dependence after the use, can let the female private department more add the elasticity moist compactness.

Further, the present application also provides a method for preparing the aforementioned care product, which may comprise, for example, the steps of: mixing the raw materials.

In an alternative embodiment, when the starting materials include hydroxyethylcellulose, triethanolamine, glycerol, ethanol, chlorhexidine acetate, menthol, PPG-26-butyether-26/PEG-40 hydrogenated castor oil, lactic acid, sodium citrate, sodium hyaluronate, and plant extracts, the preparation may be performed by the following steps: mixing glycerol, ethanol, chlorhexidine acetate, Mentholum, PPG-26-Butanol polyether-26/PEG-40 hydrogenated castor oil to obtain a first mixed solution.

And finally, mixing the first mixed solution and the third mixed solution.

By mixing the raw materials in different mixing sequences, better efficacy can be achieved than with one-time mixing.

In an alternative embodiment, the second mixture may be prepared by first mixing the hydroxyethyl cellulose with water and then mixing the hydroxyethyl cellulose with triethanolamine.

In alternative embodiments, the mixing of the hydroxyethyl cellulose with water may be carried out at 80-85 deg.C, such as 80 deg.C, 82 deg.C, or 85 deg.C. Correspondingly, the mixing device can adopt a common water boiler.

In an alternative embodiment, the second mixture can be prepared under stirring conditions, and the stirring speed can be 80-150rpm, such as 80rpm, 100rpm, 120rpm, 150rpm, or the like.

In an alternative embodiment, the aqueous solution of hydroxyethyl cellulose mixed with triethanolamine may be incubated for 20-30 min.

The preparation process of the second mixed solution can refer to: adding water and hydroxyethyl cellulose into a water kettle, heating while stirring to 80-85 deg.C, adding triethanolamine after no granule feeling, stirring, and keeping the temperature for 20-30 min.

In an alternative embodiment, the second mixed solution may be mixed with sodium citrate and lactic acid, and then sequentially mixed with sodium hyaluronate and plant extract when preparing the third mixed solution. Preferably, the second mixed solution after heat preservation is cooled to 40-45 ℃ and then mixed with sodium citrate and lactic acid.

The pH value of the base material is adjusted by lactic acid to be stable, and then the plant active matter is added to ensure that the active ingredients are more stable and are not easily affected by acid. In addition, the plant extract belongs to active substances, the activity of the plant extract is easily damaged when the temperature is too high, and the activity of the plant extract can be effectively maintained by controlling the temperature to be 40-45 ℃. When the plant extracts include the cherry tomato extract, the aloe extract, the safflower extract, the epimedium extract and the soybean extract, the second mixture may be mixed with sodium citrate and lactic acid and then sequentially mixed with sodium hyaluronate, the cherry tomato extract, the aloe extract, the safflower extract, the soybean extract and the epimedium extract.

In an alternative embodiment, the second mixture solution, the sodium citrate and the lactic acid may be mixed for 5-10min at a rotation speed of 300-500rpm, such as 5min at 300 rpm/min.

Further, all the raw materials are uniformly stirred and then are inspected, and the raw materials are taken out of the pot after the physical and chemical indexes are qualified. Wherein the physical and chemical indexes can be found in Q/RSSW 1-2017.

In conclusion, the nursing product provided by the application has the advantages of simple preparation process, low production cost, low energy consumption and easy realization of industrial production.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

A nursing product comprises, by weight, 1.5% of hydroxyethyl cellulose, 1% of triethanolamine, 3% of glycerol, 3% of ethanol, 0.15% of chlorhexidine acetate, 0.01% of menthol, 1% of PPG-26-butanol polyether-26, 1% of PEG-40 hydrogenated castor oil, 0.5% of lactic acid, 0.1% of sodium citrate, 0.05% of sodium hyaluronate and 3.1% of plant extract.

The feminine care product contains 1% of cherry tomato extract, 1% of aloe vera extract, 0.5% of safflower extract, 0.1% of soybean extract and 0.5% of epimedium extract.

The preparation method comprises the following steps:

1. weighing corresponding raw material components according to the weight, and mixing and dissolving glycerin, ethanol, chlorhexidine acetate, menthol, PPG-26-butanol polyether-26 and PEG-40 hydrogenated castor oil in advance to obtain a first mixed solution for later use;

2. adding water and hydroxyethyl cellulose into a water kettle, heating and stirring to 85 ℃, wherein the stirring speed is 150rpm/min, adding triethanolamine and stirring uniformly after no granular sensation exists, so as to obtain a second mixed solution, and keeping the temperature for 30 min;

3. and cooling the temperature of the second mixed solution to 45 ℃, adding sodium citrate and lactic acid, stirring at the rotation speed of 300rpm/min for 5min, uniformly stirring, and then sequentially adding sodium hyaluronate, the cherry tomato extract, the aloe extract, the safflower extract, the soybean extract and the epimedium extract to obtain a third mixed solution.

4. And mixing the first mixed solution and the third mixed solution, uniformly stirring, inspecting, and taking out of the pot after the physical and chemical indexes are qualified.

Example 2

A nursing product comprises, by weight, 1.5% of hydroxyethyl cellulose, 1% of triethanolamine, 3% of glycerol, 3% of ethanol, 0.15% of chlorhexidine acetate, 0.01% of menthol, 1% of PPG-26-butanol polyether-26, 1% of PEG-40 hydrogenated castor oil, 0.8% of lactic acid, 0.1% of sodium citrate, 0.05% of sodium hyaluronate and 3.1% of plant extract.

The feminine care product contains 1% of cherry tomato extract, 1% of aloe extract, 0.5% of safflower extract, 0.1% of soybean extract, and 0.5% of epimedium extract.

The preparation method is the same as that of example 1.

Example 3

A care product comprises, by weight, 1.8% hydroxyethyl cellulose, 1.5% triethanolamine, 5% glycerol, 5% ethanol, 0.2% chlorhexidine acetate, 0.05% menthol, 2% PPG-26-Butanepolyether-26, 2% PEG-40 hydrogenated castor oil, 1.5% lactic acid, 0.5% sodium citrate, 0.1% sodium hyaluronate, and 7.3% plant extract.

The feminine care product comprises 3% of a cherry tomato extract, 3% of an aloe vera extract, 1% of a safflower extract, 0.3% of a soybean extract, and 1% of an epimedium extract.

The preparation method is the same as that of example 1.

Example 4

A care product comprises, by weight, 2% of hydroxyethyl cellulose, 1.5% of triethanolamine, 5% of glycerol, 5% of ethanol, 0.3% of chlorhexidine acetate, 0.05% of menthol, 1.5% of PPG-26-Butaneth-26, 1.5% of PEG-40 hydrogenated castor oil, 1.5% of lactic acid, 0.6% of sodium citrate, 0.1% of sodium hyaluronate and 8% of a plant extract.

The feminine care product contains 2.5% of cherry tomato extract, 2% of aloe extract, 2% of safflower extract, 0.5% of soybean extract and 1% of epimedium extract.

The preparation method is the same as that of example 1.

Example 5

A care product comprises, by weight, 2% hydroxyethyl cellulose, 2% triethanolamine, 6% glycerol, 6% ethanol, 0.3% chlorhexidine acetate, 0.08% menthol, 3% PPG-26-Butaneth-26, 3% PEG-40 hydrogenated castor oil, 2.5% lactic acid, 1% sodium citrate, 0.2% sodium hyaluronate, and 10% plant extract.

The feminine care product contains 4% of cherry tomato extract, 3% of aloe vera extract, 1.5% of safflower extract, 0.5% of soybean extract and 1% of epimedium extract.

The preparation method is the same as that of example 1.

Example 6

This example differs from example 1 in that the coconut extract is a Malaysia coconut extract.

Example 7

This example differs from example 1 in that the weight ratio of soybean extract to cherry tomato extract was 0.05:0.5, the weight ratio of epimedium extract to cherry tomato extract was 0.3:0.5, the weight ratio of aloe extract to cherry tomato extract was 0.6:0.5, and the weight ratio of safflower extract to cherry tomato extract was 0.3: 0.5.

Comparative example 1

This comparative example is the same as example 3 except that the weight percent of hydroxyethyl cellulose in the care product composition is 0.5%.

Comparative example 2

This comparative example is the same as example 3 except that the weight percent of hydroxyethyl cellulose in the care product composition is 5%.

Comparative example 3

This comparative example is the same as example 3 except that the chlorhexidine acetate is present in the composition of the care product in an amount of 0.8% by weight.

Comparative example 4

This comparative example is identical to example 3, except that the care product does not contain soy extract and the cherry tomato extract is 3.3%.

Comparative example 5

The remainder of this comparative example is the same as example 3 except that the care product does not contain epimedium extract and the cherry tomato extract is 4%.

Test example 1: stability testing of Care products

The care products obtained in examples 1 to 7 and comparative examples 1 to 5 were left to stand for 90 days, and the appearance of each care product and the presence or absence of precipitation, delamination and precipitation were observed, and the results are shown in Table 1.

Table 1 stability test results

As can be seen from Table 1, the care products prepared in examples 1-7 of the present application had moderate consistency and luster appearance, and the solutions were free from precipitation, delamination and crystallization after standing for 90 days, and the solution systems were significantly better than the care products prepared in comparative examples 1-3, but the differences were not as great as the care products prepared in comparative examples 4-5.

Test example 2: sterilization testing of care products

The test is carried out according to the sanitary standard C3.2 of the disposable sanitary article of GB15979-2002, the action time is respectively 2min, 5min, 10min and 20min, the test is repeated three times for each action time, and the result is shown in Table 2.

TABLE 2 Sterilization test results

The results of sterilization tests on examples 1-7 and comparative examples 1-5 of the feminine care product show that the examples 1-7 have sterilization effects on escherichia coli, staphylococcus aureus and candida albicans within 2min, 5min, 10min and 20min, and the sterilization rate is more than 90%; and the comparative examples 1, 2, 3 and 4 can simultaneously achieve the sterilization rate of over 90 percent on escherichia coli, staphylococcus aureus and candida albicans within 10 min.

Test example 3: vaginal mucosa irritation test

The test was performed according to the vaginal mucosa irritation test in the disinfection specifications (2002 edition).

The vaginal mucosa stimulation of a new zealand rabbit test sample is selected and divided into a control group and a sample group, wherein each group comprises 3 rabbits. The animals were sacrificed 24h after exposure to the virus and the vaginal mucosal tissues were taken for pathological observation.

TABLE 3 vaginal mucosa irritation test results

Note: the average integral is the sum of the stimulation response integrals of 3 sites of 3 animals/total number of observations (number of animals × 3);

stimulation index is the mean integral of the infected group-the mean integral of the negative control group.

As can be seen from the results of the vaginal mucosa stimulation tests of examples 1-7 and comparative examples 1-5, the stimulation indexes of examples 1 and 2 to the vaginal mucosa are 0.22 and 0.11 respectively, the stimulation indexes of examples 3-7 to the vaginal mucosa are 0, and the stimulation intensities of the examples 1-7 to the rabbit vaginal mucosa are non-stimulation according to the stimulation intensity classification of the vaginal mucosa; the irritation index of the comparative example is stronger than that of examples 1-7, and the comparative example has slight irritation to the vaginal mucosa of rabbits.

Test example 4: test for Effect of Care products on growth of beneficial bacteria (Lactobacillus acidophilus GDMCC1.208)

Lactobacillus acidophilus was selected to test the effect of the care products prepared in examples 1-7 on probiotic bacteria. The inoculation mode adopts a test tube to inoculate lactobacillus acidophilus. In this example, a blank group, a positive control group, a physiological saline group and a treatment group were set, and the products prepared in examples 1 to 7 were used in the treatment groups, respectively.

Wherein, blank control group: only 15mL MRS medium.

Positive control group: taking the number of strains as 1 × 10⁵0.5mL of Lactobacillus acidophilus is inoculated in 15mL of MRS medium and cultured for 24 hours at 37 ℃ and 220 r/min.

Physiological saline group: taking the number of strains as 1 × 10⁵The Lactobacillus acidophilus is inoculated in 0.5mL of 15mL of LMRS medium, and then 0.5mL of physiological saline is added to the medium, and the medium is cultured for 24 hours at 37 ℃ and 220 r/min.

Treatment group: taking the number of strains as 1 × 10⁵The Lactobacillus acidophilus is inoculated in 0.5mL of the 15mL Sabouraud's medium, then 0.5mL of the care product of the examples of the application is added, and the mixture is cultured for 48 hours at 37 ℃ and 220 r/min.

The experimental results are as follows: compared with the positive control group without the nursing product, the turbidity of the culture solution of the treatment group added with the nursing product is consistent with that of the positive control group, and the culture solution is a light yellow turbid solution. The blank control group and the physiological saline group are clear and transparent liquids. The results show that the growth of the probiotics is not inhibited by the addition of the care product in the examples of the present application, in other words, the care product in the examples of the present application has a protective effect on the growth of the probiotics.

Experimental example 6 clinical tightening effect test

60 patients with vaginal relaxation were searched, the patients were 25-49 years old, and all were married and born with fixed partners. There were 52 cases of spontaneous labor and 8 cases of caesarean section.

Patient exclusion criteria: acute genitourinary tract infection exists, and the front wall and the back wall of the vagina or the uterus prolapse is above III degrees; serious diabetes, psychological diseases, nervous system diseases and the like are combined; there is no sexual partner.

The patients were divided into 12 groups of 5 individuals each, and randomized into groups, each of which was administered once a day with the feminine care products prepared in examples 1-7 and comparative examples 1-5, respectively, and prohibited from sexual life after use, and paid attention to keep the vulva dry.

Female sexual function was evaluated using the FSFI scale, with FSFI scoring results as shown in table 4.

TABLE 4 comparison of FSFI scores before and after patient use (points)

By evaluating the FSFI scores of all patients, the vaginal lubrication degree, the sexual life satisfaction degree and the vaginal relaxation score are all higher than those before use, which shows that the metabolism is effectively promoted, the fiber strength in the vagina is increased, and the vaginal relaxation is improved; comparing the examples with the comparative examples, the examples have higher scores than the comparative examples.

To sum up, the nursing product formula that this application provided is compatible reasonable, and each component harmony is good, has to disinfect and compacts, maintains the colony and balance, adjusts effects such as internal hormone, and is safe nonirritant, can not produce drug resistance and dependence after the use, lets the female private department more add the elasticity moist and compact. The compound of the cherry tomato extract, the soybean extract and the epimedium extract not only can nourish yin and improve vaginal relaxation, but also can appropriately supplement estrogen in human bodies, regulate endocrine in human bodies and keep the private parts compact and moist. The plant bactericidal extract such as aloe extract, epimedium extract and traditional bactericide (chlorhexidine acetate) are compounded, so that the irritation and drug resistance of the traditional bactericide can be reduced. Lactic acid is added, which is helpful for balancing weak acid state in private parts and maintaining flora balance in vivo, and keeps healthy bacteria environment in vagina. The preparation method of the nursing product has the advantages of simple process, low production cost, low energy consumption and easy realization of industrial production.

The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A care composition comprising plant extracts including coconut extract, soybean extract and epimedium extract.

2. The treatment composition as set forth in claim 1, further comprising at least one of aloe vera extract and safflower extract;

preferably, the coconut extract is a cherry tomato extract;

preferably, the weight ratio of the soybean extract to the cherry tomato extract is 0.1-0.5: 1-4;

preferably, the weight ratio of the epimedium extract to the cherry tomato extract is 0.5-1: 1-4;

preferably, the weight ratio of the aloe extract to the cherry tomato extract is 1-3: 1-4;

preferably, the weight ratio of the safflower extract to the cherry tomato extract is 0.5-2: 1-4.

3. A care product characterized in that the starting material of the care product comprises the care composition according to claim 1 or 2.

4. The care product of claim 3, wherein the ingredients of the care product further comprise at least one of a thickener, a neutralizer, a humectant, a solvent, a solubilizer, a bactericide, a cooling agent, a pH adjuster, and a pH buffer;

preferably, the thickener comprises at least one of hydroxyethyl cellulose, methyl hydroxyethyl cellulose and methyl cellulose;

preferably, the neutralizing agent comprises at least one of triethanolamine, arginine, and aminomethyl propanol;

preferably, the humectant comprises at least one of glycerin, propylene glycol, butylene glycol, and sodium 1,3 propanediol hyaluronate;

preferably, the solvent is ethanol;

preferably, the bactericide comprises at least one of chlorhexidine acetate, chlorhexidine digluconate, chlorhexidine dihydrochloride, and chlorhexidine diacetate;

preferably, the cooling agent comprises at least one of menthol and menthol;

preferably, the solubilizer comprises at least one of PPG-26-Butanethol-26/PEG-40 hydrogenated castor oil, PPG-12-Butanethol-12, PEG-20 hydrogenated castor oil, PEG-30 hydrogenated castor oil and PEG-60 hydrogenated castor oil;

preferably, the pH adjusting agent comprises at least one of lactic acid, lactobionic acid and citric acid;

preferably, the pH buffer is sodium citrate.

5. The care product of claim 4, wherein said starting materials comprise, in weight percent, 1-2.5% of said hydroxyethylcellulose, 1-2% of said triethanolamine, 3-8% of said glycerin, 3-8% of said ethanol, 0.1-0.5% of said chlorhexidine acetate, 0.01-0.1% of said menthol, 1-3% of said PPG-26-Butaneth-26/PEG-40 hydrogenated castor oil, 0.5-2.5% of said lactic acid, 0.1-1% of said sodium citrate, 0.05-0.3% of said sodium hyaluronate, and 2-15% of said plant extract, with the balance being water.

6. The care product of claim 5, wherein said starting materials comprise, in weight percent, 1.5-2% of said hydroxyethylcellulose, 1-2% of said triethanolamine, 3-6% of said glycerin, 3-6% of said ethanol, 0.1-0.3% of said chlorhexidine acetate, 0.01-0.08% of said menthol, 1-3% of said PPG-26-Butaneth-26/PEG-40 hydrogenated castor oil, 1-2.5% of said lactic acid, 0.3-1% of said sodium citrate, 0.05-0.2% of said sodium hyaluronate, and 3-15% of said plant extract, with the balance being water.

7. Process for the preparation of a care product according to any one of claims 3 to 6, characterized in that it comprises the following steps: the raw materials are mixed.

8. The method according to claim 7, wherein when the raw material comprises hydroxyethylcellulose, triethanolamine, glycerol, ethanol, chlorhexidine acetate, menthol, PPG-26-Butaneth-26/PEG-40 hydrogenated castor oil, lactic acid, sodium citrate, sodium hyaluronate and the plant extract,

the preparation method comprises the following steps: mixing the glycerol, the ethanol, the chlorhexidine acetate, the menthol and the PPG-26-butanol polyether-26/PEG-40 hydrogenated castor oil to obtain a first mixed solution;

mixing the hydroxyethyl cellulose, the triethanolamine and water to obtain a second mixed solution;

mixing the second mixed solution with the sodium citrate, the lactic acid, the sodium hyaluronate and the plant extract to obtain a third mixed solution;

and mixing the first mixed solution and the third mixed solution.

9. The method according to claim 8, wherein the second mixed solution is prepared by mixing the hydroxyethyl cellulose with water and then mixing the hydroxyethyl cellulose with the triethanolamine;

preferably, the mixing of the hydroxyethyl cellulose and the water is carried out at the temperature of 80-85 ℃;

preferably, the preparation process of the second mixed solution is carried out under the condition that the stirring rotating speed is 80-150 rpm;

preferably, the temperature of the hydroxyethyl cellulose aqueous solution mixed with the triethanolamine is kept for 20-30 min.

10. The method according to claim 9, wherein the second mixed solution is mixed with the sodium citrate and the lactic acid, and then sequentially mixed with the sodium hyaluronate and the plant extract;

preferably, when the plant extracts simultaneously include the cherry tomato extract, the aloe vera extract, the safflower extract, the epimedium extract and the soybean extract, the second mixed solution is mixed with the sodium citrate and the lactic acid and then sequentially mixed with the sodium hyaluronate, the cherry tomato extract, the aloe extract, the safflower extract, the soybean extract and the epimedium extract;

preferably, the second mixed solution after heat preservation is cooled to 40-45 ℃ and then is mixed with the sodium citrate and the lactic acid;

preferably, the mixing of the second mixed solution, the sodium citrate and the lactic acid is performed for 5-10min under the condition of the rotation speed of 300-500 rpm.