CN111838435A - Additive premix for reducing diarrhea of weaned piglets - Google Patents

Abstract

The invention discloses an additive premix for reducing diarrhea of weaned piglets, comprising a carrier and an additive composition. The additive composition consists of 2,4,6-trihydroxybenzoic acid, tea tree oil, probiotics and vitamin C, wherein the probiotics 10‑90% Lactobacillus reuteri and Bacillus subtilis. The addition amounts of 2,4,6-trihydroxybenzoic acid, tea tree oil, probiotics and vitamin C in the composition are all 10-100 mg/kg. The present invention also provides a method for using the additive premix, which can be formulated into a teaching material and a nursery material. The additive premix provided by the invention can give full play to the beneficial effects of each component. Compared with single addition, the feeding effect is better, and the antioxidant capacity of the weaned piglets can be significantly improved, and the intestinal immune function can be improved, thereby alleviating the Diarrhea, improve growth performance and protect piglet health.

Description

A kind of additive premix for reducing diarrhea of weaned piglets

technical field

The invention relates to the technical field of feed additive premix, in particular to an additive premix for reducing diarrhea of weaned piglets.

Background technique

In large-scale farming, in order to improve economic efficiency, early weaning of piglets is often selected. At this time, the immune function of piglets is not fully developed, and changes in diet, environment and other factors often lead to weaning stress, resulting in stunted growth, diarrhea, and death. Among them, diarrhea is a key factor leading to slow growth and death of piglets, which has brought huge losses to the breeding industry. The use of antibiotics can alleviate the weaning stress faced by piglets, relieve diarrhea to a certain extent, and help piglets overcome difficulties, but the harmful effects of antibiotics on the body are also increasingly prominent. my country will completely ban the addition of medicinal antibiotics to feed in 2020. Therefore, finding more suitable alternatives is the focus of current research in this industry. Numerous studies have proven that beneficial substances such as probiotics and plant essential oils have the effect of relieving weaning stress.

Patent application CN201610662894.X discloses that adding 0.01% tea tree oil to the basic diet of piglets has the effect of relieving piglet diarrhea, but the added component is single, and the relief effect on diarrhea is limited; patent application CN201910573375.X discloses a treatment for piglets The traditional Chinese medicine extract for diarrhea contains various components such as Codonopsis pilosula, Pulsatilla, Poria, Atractylodes, Chinese yam, Qinpi, Coptidis, Oregano oil, and woody incense. In addition, the special taste contained in traditional Chinese medicine will affect the feed intake of piglets to a certain extent; in addition, some researchers (Zhou Meng et al., Journal of Animal Nutrition, 2014, 26(02), 445-452; Liu Hu Chuan et al., Journal of Animal Nutrition, 2012, 24(07), 1329-1335.) The study showed that adding probiotics to piglets’ diets can improve the intestinal immunity of piglets, improve digestibility, and then relieve piglet diarrhea, which has a negative impact on growth. The performance also improved to some extent, but its beneficial effect gradually diminished over time. In general, the antibiotic substitutes currently used in the market have their own defects. Based on this, the present invention provides an additive premix for reducing diarrhea of weaned piglets, which can relieve diarrhea of piglets, improve growth performance, and is simple to prepare. The cost is low and the beneficial effect is obvious to make up for the market vacancy.

SUMMARY OF THE INVENTION

The technical problem to be solved by the present invention is to provide an additive premix for reducing diarrhea of weaned piglets. The additive premix can significantly improve the growth performance of piglets, reduce the diarrhea rate, and ensure the health of piglets, so as to replace the application of antibiotics in piglets .

In order to solve the above problems, the present invention provides an additive premix for reducing diarrhea of weaned piglets, including a carrier and an additive composition, the additive composition is composed of 2,4,6-trihydroxybenzoic acid, tea tree oil, probiotics. bacteria and vitamin C.

The carrier of the present invention is a mixture of one or more of montmorillonite powder, zeolite powder and corn starch.

The probiotics of the invention are composite probiotics powder composed of Lactobacillus reuteri and Bacillus subtilis, wherein the proportion of Lactobacillus reuteri is 10-90%.

Further, the addition amount of each component in the additive composition of the present invention is 10-100 mg/kg of 2,4,6-trihydroxybenzoic acid, 10-100 mg/kg of tea tree oil, and 10-100 mg/kg of probiotics. kg, vitamin C 10-100mg/kg.

The advantages of the additive composition of the present invention are: 2,4,6-trihydroxybenzoic acid belongs to carboxyl group-containing polyphenols and exists in various natural plants. Polyphenols are a class of natural and safe antioxidants, which can increase the activity of glutathione peroxidase, superoxide dismutase, etc. in the body, thereby alleviating oxidative stress in the body. It is acidic and has antibacterial function; the main component of tea tree oil is 4-terpineol, which has broad-spectrum antibacterial, antioxidative, antitumor and immune-enhancing effects. Its application in piglets can improve growth performance and relieve diarrhea. At the same time, it can also improve the structure of the flora in the digestive tract and promote the balance of the micro-ecology; Lactobacillus reuteri and Bacillus subtilis, two commonly used probiotics in production, can interact with harmful bacteria (such as Escherichia coli that cause diarrhea) in the intestinal tract of the body. Competing for colonization sites, increasing the proportion of beneficial bacteria in the intestine, can also promote the catabolism of the contents, producing active substances such as short-chain fatty acids, thereby relieving diarrhea and improving growth performance; vitamin C is an essential vitamin, maintaining normal cell metabolism, It can enhance the body's anti-stress ability and immunity to the external environment, and it is also a beneficial substance that must be added to the piglet feed.

The method for using the additive premix for reducing diarrhea of weaned piglets provided by the present invention can be added to the piglet teaching trough feed and the nursery feed at a ratio of 1-5 kg/ton.

Advantages and beneficial effects of the present invention: Considering the needs of weaned piglets, unique and harmless beneficial active substances, plant essential oils, probiotics and vitamins are used as composite additives. Through theoretical derivation and experimental verification, a A better ratio can give full play to the beneficial effects of each component. Compared with single addition, the effect is better; without the use of antibiotics, it can significantly improve the antioxidant capacity of weaned piglets, improve intestinal immune function, and ensure Piglet intestinal function, thereby alleviating diarrhea, improving growth performance, and ensuring piglet health, thereby significantly improving economic efficiency.

Detailed ways

The following specific examples are given to illustrate the present invention. The examples are only used to further illustrate the present invention and do not represent the protection scope of the present invention. Non-essential modifications and adjustments made by others according to the present invention still belong to the protection of the present invention. scope.

Example 1

An additive premix for reducing diarrhea of weaned piglets, comprising a carrier and an additive composition, the additive composition is composed of 10 mg/kg of 2,4,6-trihydroxybenzoic acid, 100 mg/kg of tea tree oil, and 70 mg/kg of probiotics. kg, vitamin C 10 mg/kg, the carrier is zeolite powder, mixed evenly, and added to the piglet teaching trough feed at a rate of 1 kg/ton.

Example 2

An additive premix for reducing diarrhea in weaned piglets, comprising a carrier and an additive composition, the additive composition is composed of 30 mg/kg of 2,4,6-trihydroxybenzoic acid, 60 mg/kg of tea tree oil, and 100 mg/kg of probiotics. kg, vitamin C 80 mg/kg, the carrier is montmorillonite powder, mixed evenly, and added to the piglet teaching trough feed at a rate of 2.5 kg/ton.

Example 3

An additive premix for reducing diarrhea in weaned piglets, comprising a carrier and an additive composition, wherein the additive composition is composed of 60 mg/kg of 2,4,6-trihydroxybenzoic acid, 30 mg/kg of tea tree oil, and 50 mg/kg of probiotics. kg, vitamin C 100 mg/kg, the carrier is corn starch, mixed evenly, and added to the piglet teaching trough feed at a rate of 5 kg/ton.

Example 4

An additive premix for reducing diarrhea in weaned piglets, comprising a carrier and an additive composition, the additive composition is composed of 100 mg/kg of 2,4,6-trihydroxybenzoic acid, 80 mg/kg of tea tree oil, and 10 mg/kg of probiotics. kg, vitamin C 40 mg/kg, the carrier is montmorillonite powder, mixed evenly, and added to the piglet nursery feed at a rate of 1 kg/ton.

Example 5

An additive premix for reducing diarrhea of weaned piglets, comprising a carrier and an additive composition, the additive composition is composed of 80 mg/kg of 2,4,6-trihydroxybenzoic acid, 70 mg/kg of tea tree oil, and 40 mg/kg of probiotics. kg, vitamin C 60 mg/kg, the carrier is zeolite powder, mixed evenly, and added to the piglet nursery feed at a rate of 2.5 kg/ton.

Example 6

An additive premix for reducing diarrhea in weaned piglets, comprising a carrier and an additive composition, the additive composition is composed of 70 mg/kg of 2,4,6-trihydroxybenzoic acid, 10 mg/kg of tea tree oil, and 80 mg/kg of probiotics. kg, vitamin C 30 mg/kg, the carrier is corn starch, mixed evenly, and added to the piglet nursery material at a rate of 5 kg/ton.

Application example 1

96 Du × (long × big) weaned boars (21-23 d) were selected and divided into 3 groups, with 8 replicates in each group, and 4 pigs in each replicate: (1) Negative control group, fed Corn-soybean meal basal diet; (2) positive control group, fed with corn-soybean meal basal diet + antibiotics (70 g/t olaquindox + 75 g/t chlortetracycline + 20 g/t anthocyanin) (3) The test group was fed with corn-soybean meal type basal ration + the present invention's gained additive premix. All piglets were weighed at 8:00 in the morning on the first day of the experiment and recorded as the initial weight; on the 14th day of the experiment, the feeding was stopped at night, and after a 12-h fast, the piglets were weighed again at 8:00 in the morning of the next day, which was the final weight; Feed feeding at 8:00, 12:00, 16:00, and 20:00 every day, record the feeding amount and remaining feed amount of each group of piglets every day; record the piglet diarrhea every day (refer to the method provided in Table 1). Specific index calculation method:

Average daily gain = (final weight of piglets in each group - initial weight)/test days;

Average daily feed intake = (feed amount of piglets in each group - remaining feed amount)/test days;

Feed-to-weight ratio = average daily feed intake/average daily gain;

Diarrhea index = average diarrhea grade of diarrhea rate, diarrhea rate = number of diarrhea per piglet/total number of diarrhea, average diarrhea grade = sum of diarrhea score per pig/number of diarrhea. The test results are as follows:

Table 1 Evaluation standard of piglet diarrhea index

degree The appearance of stool score normal normal, cylindrical 0 mild diarrhea soft, tangible 1 moderate diarrhea Sticky, shapeless, high moisture content 2 severe diarrhea Liquid, formless, watery loose stools 3

Calculate the average daily gain, average daily feed intake, and feed-to-weight ratio of each group of piglets during the test period, and the results are shown in Table 2; it can be seen from Table 2 that the pigs using the additive premix of the present invention (ie, the test group), the average The daily gain and average daily feed intake were significantly higher than those of the negative control group, while the feed-to-weight ratio was lower, which was basically the same as the growth performance of the pigs in the antibiotic-added group, indicating that the additive premix of the present invention significantly improved the growth of weaned piglets. effect of performance.

Table 2 Influence of additive premix of the present invention on growth performance of weaned piglets

grouping Average daily weight gain (g) Average daily feed intake (g) Material to weight ratio test group 247 299 1.21 positive control group 240 287 1.20 negative control group 178 259 1.46

According to the piglet diarrhea index evaluation standard provided in Table 1, the diarrhea index of the piglets was calculated, and the results were shown in Table 3. As can be seen from Table 3, the piglets using the additive premix of the present invention had a piglet diarrhea index significantly lower than that of the negative control group. It is demonstrated that the additive premix of the present invention has a significant effect on improving diarrhea of weaned piglets.

Table 3 Piglet diarrhea index

grouping Diarrhea Index test group 4.52 positive control group 4.55 negative control group 7.06

In conclusion, the additive premix obtained by the present invention can significantly reduce the diarrhea rate of weaned piglets, improve the growth performance of piglets to a certain extent, and further improve the overall health of piglets. Therefore, in the stage of early weaning of piglets in the farm, the use of the additive premix of the present invention can reduce diarrhea, improve growth performance, better protect the health of piglets, and thus improve economic benefits.

Claims (6)

1. an additive premix for reducing diarrhea of weaned piglets, comprising a carrier and an additive composition, characterized in that: the additive composition is composed of 2,4,6-trihydroxybenzoic acid, tea tree oil, probiotics and vitamin C composition. 2 . The additive premix for reducing diarrhea of weaned piglets according to claim 1 , wherein the carrier is a mixture of one or more of montmorillonite powder, zeolite powder and corn starch. 3 . 3. The additive premix for reducing diarrhea of weaned piglets according to claim 1, wherein the probiotics in the additive composition are the composite probiotics powder composed of Lactobacillus reuteri and Bacillus subtilis, wherein the probiotics are composed of Lactobacillus reuteri and Bacillus subtilis. The mass proportion of Escherichia coli is 10-90%. 4. The additive premix for reducing diarrhea of weaned piglets according to claim 1, is characterized in that: the addition amount of each component in the additive composition is 2, 4, 6-trihydroxybenzoic acid 10-100 mg/ kg, tea tree oil 10-100 mg/kg, probiotics 10-100 mg/kg, vitamin C 10-100 mg/kg. 5. the additive premix for reducing diarrhea of weaned piglets according to claim 1 or 2 or 3 or 4, is characterized in that: described additive premix is added according to the ratio of 1-5 kg/ton of piglet teaching trough material middle. 6. the additive premix for improving pork meat quality according to claim 1 or 2 or 3 or 4, is characterized in that: the additive premix is added to the piglet nursery material according to the ratio of 1-5 kg/ton middle.