CN111838165A - Herbicide composition containing atrazine and application thereof - Google Patents

Abstract

The invention relates to an atrazine-containing herbicide composition, which comprises an active component; the active component comprises an active component A and an active component B, wherein the active component A is Atrazine (Atrazine); the active component B is a compound with a structure shown in a formula I and pharmaceutically acceptable salt thereof;

Description

Atrazine-containing herbicidal composition and application thereof

technical field

The invention belongs to the field of agricultural herbicides, and relates to an atrazine-containing herbicide composition and application thereof.

Background technique

Sorghum has been regarded as a pioneer crop in China's dryland farmland because of its characteristics of drought resistance, waterlogging resistance, salinity resistance, and barren resistance. In recent years, with the increasing trend of mechanization, scale and labor force reduction in agriculture, chemical weed control technology in sorghum field will become an indispensable and important measure in sorghum production. Sorghum belongs to the category of "small grains", and there are few special herbicides or registered varieties.

At present, the herbicides in sorghum fields are mainly soil sealants compounded by atrazine and amides. The efficacy of closed herbicides is greatly affected by the environment, especially soil moisture. The efficacy of closed herbicides declines significantly in arid areas and under no-tillage conditions. Therefore, the purpose of weed control can only be achieved by increasing their use. Atrazine is the most widely used herbicide in sorghum fields, and its long-term high-dose use has caused environmental damage and increased weed resistance. Atrazine can only be partially decomposed after 180 days in the natural environment. At the same time, atrazine has strong leaching properties and is easy to migrate down in the soil and enter the groundwater, thereby causing groundwater pollution and having a great impact on the soil environment. Moreover, due to the long-term use of atrazine, it has also led to the formation of a large number of resistant weed populations and the phenomenon of weed community succession. , Tian Convolvulus rose to dominant weeds; crabgrass resistance to atrazine increased, and the control effect decreased. To sum up, atrazine exists in a large amount, and there are many residues in the soil, and the control effect of some atrazine-resistant weeds (mainly crabgrass) is poor.

Chinese Patent 201810139901.7 discloses a compound and its herbicidal activity (the structural formula is as follows), the compound is mainly used in paddy fields, and has control effect on penoxsulam-resistant barnyard grass, annual and perennial grasses and broadleaf weeds, However, the patent scheme does not mention its use in combination with other herbicides.

SUMMARY OF THE INVENTION

The technical problem to be solved by the present invention is to provide a herbicide composition containing atrazine, which can be used to control weeds such as sorghum field barnyardgrass, crabgrass, quinoa, amaranth, etc., but is very safe for sorghum; At the same time, it also has an excellent control effect on the crabgrass that is resistant to atrazine, and achieves the purpose of complementing its advantages.

The technical scheme of the present invention is:

An atrazine-containing herbicidal composition, comprising an active component; the active component includes an active component A and an active component B, and the active component A is atrazine;

The active ingredient B is a compound of formula I and a pharmaceutically acceptable salt thereof;

Wherein, the mass ratio of active ingredient A and active ingredient B is 10:1-80.

Wherein, the pharmaceutically acceptable salt is the salt formed by the compound of formula I with amines, alkali metal and alkaline earth metal bases or quaternary ammonium salt bases, respectively.

According to a preferred embodiment of the present invention, wherein: the total application amount of the active component is 300 ga.i./hm ² , and the mass ratio of the active component A to the active component B is 1:1 to 1:4 (Note : g ai/hm ² , i.e. grams of active ingredient per hectare). Under the dosage and ratio, the overall control effect on weeds such as barnyardgrass, crabgrass and abalone is as high as 98%.

According to a preferred embodiment of the present invention, wherein: the mass ratio of the active ingredient A to the active ingredient B is 5:1 to 1:2; more preferably, it is 5:1 to 1:1. Mixed in this ratio, when the total application amount of active components is 180-300g ai/hm ² , the difference between the measured control effect E and the theoretical control effect E ₀ is the largest, and the effect of mutual synergistic gain of the two components is the most significant. .

According to a preferred embodiment of the present invention, wherein: the herbicide composition further comprises adjuvants; the adjuvants include surfactants, wetting agents, dispersing agents, emulsifiers, fast penetration agents, solvents and fillers and other beneficial agents The known substances for the stability of the active ingredient in the formulation and the exertion of the medicinal effect can be various ingredients commonly used or allowed to be used in the pesticide formulation. For example, the active ingredient can be formulated into emulsifiable concentrates, waters, concentrated emulsions, microemulsions, wettable powders, water suspensions, oil suspensions, water dispersible granules, or soluble powders (granules) and the like. The surfactant is sodium lauryl sulfate, sodium secondary alkyl sulfate, sodium dodecylbenzenesulfonate, polyoxyethylene fatty acid ester, polyoxyethylene fatty alcohol ether, polyoxyethylene fatty ammonia, ethoxylate base castor oil, fatty acid polyethylene glycol ester, alkylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, etc.

According to a preferred embodiment of the present invention, wherein: the total content of the active components in the herbicide composition is 0.5-95.0 wt %.

According to a preferred embodiment of the present invention, wherein: the herbicide composition is a solid dispersion formulation or a liquid dispersion formulation. The liquid dispersion preparation includes one or more of emulsifiable concentrates, water-dispersible granules, concentrated emulsions, microemulsions, wettable powders, water suspensions and oil suspensions. The solid dispersion preparation is soluble powder/soluble granule and the like.

According to a preferred embodiment of the present invention, wherein: the herbicidal composition is a premixed formulation or a two-component individually packaged formulation; the active ingredient A and the active ingredient B in the premixed formulation have been pre-mixed in mass proportions, and are mixed with water before use. /soil/fertilizer diluted to a predetermined concentration; the two-component individually packaged preparations are separately packaged according to mass ratio, mixed before use, and diluted with water/soil/fertilizer to a predetermined concentration before use.

The present invention also relates to the application of the above-mentioned atrazine-containing herbicide composition in the control of weeds in sorghum fields, the weeds include annual and perennial grass and broadleaf weeds in sorghum fields, especially barnyardgrass, crabgrass, Quinoa, amaranth, abalone, polygonum and other weeds, and in the control of barnyardgrass, crabgrass, abalone and other weeds have obvious advantages.

The herbicidal composition of the present invention can be used in admixture with other compounds with herbicidal, insecticidal or fungicidal properties, especially herbicides for soil treatment, as well as with nematicides, repellants, growth regulators, plant nutrients or soil regulators Mixed use.

The technical effects of the atrazine-containing herbicidal composition of the present invention include:

(1) The researchers further studied the compound of formula I and found that although the compound of formula I showed efficient control of annual and perennial grass and broadleaf weeds in paddy fields, especially for barnyard grass, crabgrass, Quinoa, amaranth, etc. have very good control effects, wherein barnyardgrass belongs to the annual Gramineae weed, and crabgrass also belongs to Gramineae, but the compound of formula I structure is very safe to sorghum belonging to the same family of Gramineae, which makes the structure of formula I very safe. The compounds can be used for the control of other grass and broadleaf weeds in sorghum fields.

(2) The present invention combines atrazine with the compound of formula 1, and achieves a good synergistic effect, which can not only reduce the amount of atrazine, but also reduce the residue in the soil, especially the atrazine resistance. Crabgrass also has excellent control effect, achieving a good complementary effect.

(3) for the problems such as the existing special herbicides for sorghum field or the registered varieties, and it is difficult to control all weeds with a single agent, the present invention combines atrazine with the compound of formula I structure, and is effective against barnyardgrass. Grass, crabgrass, broad-leaved weeds, quinoa, abalone, etc. have good control effects. Mixed use has obvious synergistic effect. Each agent can complement each other's advantages, which not only achieves the purpose of expanding the weed killing spectrum, but also reduces costs and reduces the number of applications. and the amount of atrazine used to slow down the selection of atrazine-resistant weeds and save labor.

Compared with the prior art, the present invention uses the compound of formula I structure and its pharmaceutically acceptable salt and atrazine in combination according to a certain proportion for the first time, and has achieved unexpected technical effects, making the two herbicidal active ingredients not only Complementary advantages have been achieved, and the weed control ability has been significantly increased. This shows that the compound of formula I and its pharmaceutically acceptable salt and the two herbicidal active ingredients of atrazine have a synergistic effect when used in combination, and have the effect of synergistic gain.

Detailed ways

In order to make the technical effects of the present invention more clearly understood, the following description is made in conjunction with the specific embodiments of the present invention. However, it is pointed out that the herbicidal composition based on the idea of the present invention can be prepared into any formulation suitable for agricultural use by known methods, and is not limited to the types listed in the following examples.

Example 1

The herbicide composition of this embodiment is a wettable powder, wherein the total content of active components is 66wt%, wherein atrazine is 60wt%, and the active component B is a compound of formula I, and the content is 6wt%.

The adjuvants used are: sodium dodecylbenzenesulfonate 2.0wt%, white carbon black 5wt%, sodium lignosulfonate 10wt%, and finally supplemented with diatomaceous earth to 100wt%.

Preparation method: according to the above formula, the active ingredient atrazine, the compound of formula I structure, auxiliary agents and fillers are fully mixed, and after being pulverized by an ultrafine pulverizer, the corresponding wettable powder pesticide can be prepared.

Example 2

The herbicide composition of this embodiment is a water-dispersible granule, wherein the total content of active components is 42wt%, of which atrazine is 35wt%, and the active component B is a compound of formula I, and the content is 7wt%.

The auxiliary agents used are: 12wt% of sodium methylenebisnaphthalene sulfonate formaldehyde condensate, 5wt% of citric acid, 15wt% of soluble starch, and finally supplemented to 100wt% with gypsum.

Preparation method: Mix and pulverize the active components and auxiliary agents according to the above formula, obtain water-dispersible granules through spray drying or boiling drying, or add water and knead them, and then add them to a granulator equipped with a certain size screen for granulation. grain. Then it is dried and sieved (according to the screen range) to obtain granular products.

Example 3

The herbicide composition of the present embodiment is an oil suspension agent, wherein the total content of active components is 20wt%, wherein atrazine is 10wt%, and the active component B is a compound of formula I, and the content is 10wt%.

The adjuvants used are: fatty alcohol polyoxyethylene ether 5wt%, glycerol monolaurate polyoxyethylene ether 10wt%, fast penetration agent T10wt%, and finally supplemented to 100wt% with vegetable oil.

Preparation method: according to the above formula, the active components and auxiliary agents are mixed uniformly, added into a sand grinding kettle, and ground to be fine, and then the corresponding oil suspension agent product can be prepared.

Example 4

The herbicide composition of the present embodiment is an emulsifiable concentrate, wherein the total content of active components is 9wt%, of which atrazine is 3wt%, and the active component B is a compound of formula I, and the content is 6wt%.

The additives used are: N,N-dimethylformamide 10wt%, fatty alcohol polyoxyethylene ether 10wt%, glycerol monolaurate polyoxyethylene ether 10wt%, fast penetration agent T10wt%, and finally supplemented with solvent oil. to 100wt%.

Preparation method: according to the above formula, the active component and the auxiliary agent are mixed, and the corresponding emulsifiable concentrate product can be prepared by dissolving into a uniform oil phase.

Example 5

The herbicide composition of this embodiment is an aqueous emulsion, wherein the total content of active components is 20 wt%, of which atrazine is 4 wt%, and the active component B is a compound of formula I, and the content is 16 wt%.

The additives used are: N-methylpyrrolidone 5wt%, polyvinyl alcohol 0.8wt%, sorbitan fatty acid ester polyoxyethylene ether 5wt%, alkyl-diethylene glycol ether-sodium sulfonate 2.5wt% %, agricultural milk 2201 2wt%, ethylene glycol 5wt%, and finally make up to 100wt% with water.

Preparation method: according to the above formula, the active components and auxiliary agents are mixed to dissolve into a uniform oil phase. Mix water, antifreeze, etc. to form a homogeneous aqueous phase. Under high-speed stirring, the water phase is added to the oil phase or the oil phase is added to the water phase to form a water emulsion with good dispersibility.

Example 6

The herbicide composition of the present embodiment is a suspending agent, wherein the total content of active components is 18 wt %, wherein atrazine is 2 wt %, and the active component B is a compound of formula I, and the content is 16 wt %.

The additives used are: sodium lignosulfonate 5wt%, white carbon black 0.3wt%, agricultural milk 2201 5wt%, glycerol 8wt%, a little silicone, and finally water to make up to 100wt%.

Preparation method: mix the active components and auxiliary agents according to the above formula, and grind them by a sand mill for 2-4 hours to make the average particle size below 5 microns, and then the corresponding suspending agent product can be prepared.

Determination of herbicidal effect

(1) the herbicidal control effect is measured to the combined herbicide composition of embodiment 1-6, the independent atrazine herbicide, the independent compound herbicide of formula I structure, and the assay method is as follows:

Under greenhouse conditions, the method of potted cultivation was used. Specifically, in each disposable plastic flowerpot with a diameter of 20cm, an equal amount of sifted soil is loaded, and the same amount of weed seeds are sown, and 15-20 seeds are sown in each pot (seeds are barnyardgrass, abalone) Mahe potted plant), cover with soil 0.5-1cm and then flatten. Place the pot in a stainless steel square pan to allow it to naturally absorb water from the bottom until the soil is saturated. The test materials were cultured in a greenhouse, and the stem and leaf spraying treatment was carried out at the 5-6 leaf stage of barnyardgrass and the 4-leaf stage of abalone, and each treatment was repeated 3 times, and a blank control was set. After 6 hours of treatment, they were placed in a greenhouse for routine management, and observed and recorded. After 30 days, the fresh weight of each treated weed was investigated, and the fresh weight control effect (%) of each treatment was calculated.

When calculating the control effect of fresh weight, the green part of the weeds of each treatment (flower pot) should be cut off and weighed, and then the fresh weight control effect % of each treatment should be calculated according to the following formula. The fresh weight control effect was calculated separately for each weed.

According to the above method, the control effects of the herbicidal compositions of Examples 1-6, the atrazine herbicide alone, and the compound herbicide with the structure of formula I alone on barnyardgrass and abalone were calculated. And the fresh weight control effect was recorded as the measured control effect value as shown in Table 1 and Table 2.

Table 1. Control efficacy of different herbicides on barnyardgrass

Table 2. Control efficacy of different herbicides on abalone

In Table 1 and Table 2: the dosage (ga.i./hm ² ) represents the dosage of the herbicidal active ingredient per hectare. The measured control effect %E is calculated by the above calculation formula of fresh weight control effect.

Theoretical control effect %E ₀ calculation theory and basis are:

The theoretical efficacy of the combined effect of two herbicides was evaluated by Gowing method. The formula for calculating the mixing effect is: E ₀ =X+Y-XY/100, in which: X represents the weed control effect of the herbicidal active ingredient A when the dosage is P; Y represents the weeds of the herbicidal active ingredient B when the dosage is Q Control effect; E ₀ represents the theoretical control effect of herbicide (A+B) when the herbicide dosage is (P+Q).

According to the Gowing method, when EE ₀ >0, it means that there is a synergy between the two herbicides mixed, that is, the two herbicidal active ingredients are mixed to produce a synergistic effect; when EE ₀ =0, it means that the mixed herbicide produces a phase of Additive effect, when EE ₀ <0, indicating that the mixed herbicides produce antagonistic effect.

Referring to Table 1-Table 2, it is obvious that atrazine is used in combination with the compound of formula ¹ in an amount of 15-1200 ^g ai/hm in an amount of 150 g ai/hm , so that atrazine: the mass ratio of the compound of formula 1 is used in combination. When the ratio is 10:1 to 1:8, the measured control effect E of barnyardgrass is greater than its theoretical control effect E ₀ , and the minimum EE ₀ is 5.1, and the maximum is 16.7; the measured control effect E of abalone and barnyardgrass is greater than Its theoretical prevention effect E ₀ , and the EE ₀ minimum is 5.1, and the maximum is 16.6. Among them, when the mass ratio of atrazine: the compound of formula 1 is in the range of 5:1 to 1:1, the mutual synergistic effect of the two components is particularly significant, and the application amount can be minimized. When the dosage of atrazine is 150g ai/hm ² and the dosage of the compound of formula 1 is 300g ai/hm ² , the measured control effect on barnyardgrass reaches 95.4%, and the measured control effect on abalone reaches 95.3%. It can be said that this The proportion and application rate of the species are very effective for barnyardgrass and abalone.

From this, it can be concluded that when atrazine and the compound of formula 1 are used in combination as the active components of herbicides in Examples 1-6 of the present invention, there is a synergy between the active components of the two herbicides, that is, the two active components are synergistic. Herbicidally active ingredients produce synergistic benefits.

(2) Determination of control effect on mixed weeds

Test method: Put an equal and appropriate amount of sieved loam in a disposable plastic flower pot with a diameter of 20cm, and sow a quantitative amount of weed seeds and sorghum seeds. Each pot is sown with 15-20 weed seeds and 10 sorghum seeds. Grains (crabgrass, barnyardgrass, abalone and sorghum seeds are sown in combined pots), covered with soil 0.5-1cm and then flattened. Place the pot in a stainless steel square pan to allow it to naturally absorb water from the bottom until the soil is saturated. The test material is placed in the greenhouse for cultivation, and the stem and leaf spraying is carried out when the 5-6 leaf stage of barnyard grass, the 4-6 leaf stage of abalone, the 4-6 leaf stage of crabgrass, and the 5-6 leaf stage of sorghum are carried out. Repeated 3 times, and set blank control. After 6 hours of treatment, they were placed in a greenhouse for routine management, and observation records were made regularly. After 30 days, the fresh weight of each treated weed was investigated, and the fresh weight (%) was calculated. The plant height, leaf color and growth of sorghum were visually observed and compared with the control to evaluate the safety to sorghum. The results are shown in Table 3.

Table 3. The control effect results of the composition examples on weeds (% of fresh weight control effect)

Note: The fresh weight control effect and overall fresh weight of a single weed in the table are the average of three replicates.

In the above table, the calculation method of the overall fresh weight control effect is: add up the fresh weight of the aboveground parts of various weeds in each treatment (flower pot) to obtain the total weight, and the calculation formula of the control effect is:

It can be clearly seen from Table 3 that when atrazine is used alone, the measured control effect on barnyardgrass is only 30.8%, only 20.6% ^on crabgrass, 60.1% on abalone, and 60.1% on three The overall control effect of weeds is only 40.5%, and the overall control effect is very poor; the measured control effect of compound B (the compound of formula I) alone is only 70.2% and 70.6% for barnyardgrass and abalone, and the measured control effect for crabgrass is only 70.2% and 70.6%. was slightly higher at 80.8%, while the overall control efficacy against the three weeds was only 73.6%.

In Examples 1-6, when atrazine and compound B are used in combination, they have good control effects on barnyardgrass, crabgrass and abalone, and the measured control effect is between 85.4-100%. The overall control effect of the three weeds was also above 90%. This shows that the combination of atrazine and the compound of formula I used as a herbicidal active substance can significantly improve the overall herbicidal effect, expand the herbicidal spectrum, and have good practical value. After the treatment, the safety of sorghum was regularly investigated. Regardless of the pre-application and the final investigation results, the plant height, leaf color, growth and other aspects of each treatment were not different from those of the control. Safe and non-toxic.

It can be seen from Examples 3-5 that when the total application amount of active components is 300 g ai/hm ² , if the mass ratio of active component A and active component B is 1:1 to 1:4, the mixed herbicide obtained will be effective for The overall control effect of barnyardgrass, crabgrass and abalone reached more than 98%. It can be said that when the mass ratio of active ingredient A and active ingredient B is 1:1 to 1: ⁴ , and the application rate (converted to the amount of active ingredient) is 300g ai/hm2, the annual and It is very effective in controlling perennial grasses and broadleaf weeds and is very safe for sorghum.

In addition, the herbicidal composition based on the idea of the present invention can be prepared into any formulation suitable for agricultural use by known methods, and is not limited to the types listed in the following examples. Wherein, the compound of formula I can also be replaced by a pharmaceutically acceptable salt, such as a salt formed by the compound of formula (I) with amines, alkali metal and alkaline earth metal bases or quaternary ammonium salt bases.

The above-mentioned embodiments merely describe the preferred embodiments of the present invention, and do not limit the scope of the present invention. Without departing from the design spirit of the present invention, those of ordinary skill in the art can make various modifications to the technical solutions of the present invention. Variations and improvements should fall within the protection scope determined by the claims of the present invention.

Claims (10)

1. An atrazine-containing herbicide composition characterized by comprising an active ingredient;

the active component comprises an active ingredient A and an active ingredient B, wherein the active ingredient A is atrazine;

the active component B is a compound with a structure shown in a formula I and pharmaceutically acceptable salt thereof;

wherein the mass ratio of the active component A to the active component B is 10: 1-80.

2. The atrazine-containing herbicide composition as claimed in claim 1, wherein the pharmaceutically acceptable salt is a salt formed by a compound having a structure represented by formula I and amines, alkali metal and alkaline earth metal bases or quaternary ammonium bases.

3. The atrazine-containing herbicide composition as claimed in claim 1, wherein the total application rate of the active ingredients is 300ga.i./hm²And the mass ratio of the active ingredient A to the active ingredient B is 1: 1-1: 4.

4. The atrazine-containing herbicide composition as claimed in claim 1 or 3, wherein the mass ratio of the active ingredient A to the active ingredient B is 5:1 to 1: 2; more preferably 5:1 to 1: 1.

5. The atrazine-containing herbicide composition as claimed in claim 1, further comprising an adjuvant; the auxiliary agent comprises one or more of a quick penetration agent, a surfactant, a wetting agent, a dispersing agent, an emulsifying agent, a solvent and a filler.

6. The atrazine-containing herbicide composition as claimed in claim 5, wherein the total content of the active ingredients in the herbicide composition is 0.5 to 95.0 wt%.

7. The atrazine-containing herbicide composition as claimed in claim 5, wherein the herbicide composition is a solid dispersion formulation or a liquid dispersion formulation.

8. The atrazine-containing herbicide composition as claimed in claim 5, wherein the herbicide composition is a pre-mixed formulation or a two-component individually packaged formulation; the active ingredient A and the active ingredient B in the premixed preparation are premixed according to the mass proportion and diluted to a preset concentration by adding water/soil/fertilizer before use; the double-component individually packaged preparation is packaged according to the mass ratio, is automatically mixed before use, and is diluted to a preset concentration by adding water/soil/fertilizer before use.

9. Use of an atrazine-containing herbicide composition in the control of weeds in sorghum fields according to any one of claims 1 to 8, characterized in that the weeds comprise annual and perennial grasses and broadleaf weeds in sorghum fields.

10. Use according to claim 9, wherein the weeds comprise Echinochloa crusgalli, crab grass, Abutilon.