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CN111803635B - 小分子抑制剂在治疗呼吸道病毒性肺炎上的应用 - Google Patents

小分子抑制剂在治疗呼吸道病毒性肺炎上的应用 Download PDF

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Publication number
CN111803635B
CN111803635B CN202010701456.6A CN202010701456A CN111803635B CN 111803635 B CN111803635 B CN 111803635B CN 202010701456 A CN202010701456 A CN 202010701456A CN 111803635 B CN111803635 B CN 111803635B
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China
Prior art keywords
virus
ahr
ifn
viral pneumonia
inhibitor
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CN202010701456.6A
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English (en)
Chinese (zh)
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CN111803635A (zh
Inventor
黄波
刘玉英
佟伟民
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Institute of Basic Medical Sciences of CAMS and PUMC
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Institute of Basic Medical Sciences of CAMS and PUMC
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Priority to PCT/CN2020/113478 priority Critical patent/WO2021253647A1/fr
Publication of CN111803635A publication Critical patent/CN111803635A/zh
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/405Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202010701456.6A 2020-06-17 2020-07-20 小分子抑制剂在治疗呼吸道病毒性肺炎上的应用 Active CN111803635B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2020/113478 WO2021253647A1 (fr) 2020-06-17 2020-09-04 Utilisation d'un inhibiteur de petites molécules dans le traitement de la pneumonie virale respiratoire

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202010552732 2020-06-17
CN2020105527327 2020-06-17

Publications (2)

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CN111803635A CN111803635A (zh) 2020-10-23
CN111803635B true CN111803635B (zh) 2023-03-14

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CN202010701456.6A Active CN111803635B (zh) 2020-06-17 2020-07-20 小分子抑制剂在治疗呼吸道病毒性肺炎上的应用
CN202010919429.6A Active CN113797337B (zh) 2020-06-17 2020-09-04 小分子抑制剂在预防及治疗呼吸道病毒性肺炎中的应用

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CN202010919429.6A Active CN113797337B (zh) 2020-06-17 2020-09-04 小分子抑制剂在预防及治疗呼吸道病毒性肺炎中的应用

Country Status (2)

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CN (2) CN111803635B (fr)
WO (1) WO2021253647A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118490680B (zh) * 2023-06-20 2025-02-11 吉林省西点药业科技发展股份有限公司 瑞香素在制备治疗病毒性肺炎的药物中的应用
CN119258221B (zh) * 2024-12-11 2025-04-04 吉林大学 AhR激动剂在制备治疗放射性肺炎药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103169970A (zh) * 2011-12-25 2013-06-26 复旦大学 一种治疗病毒性肺炎的药物组合物

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
CA2375647A1 (fr) * 1999-07-08 2001-01-18 Patrick T. Prendergast Utilisation de flavones, de coumarines et de composes associes dans le traitement d'infections
EP1418164A1 (fr) * 2002-11-07 2004-05-12 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nouveaux derivés de stilbène et leur utilisation en tant que antagonistes des ligands du recepteur des arylhydrocarbures
CN107648216B (zh) * 2010-07-27 2021-03-30 波士顿大学管理委员会 作为新型癌症疗法的芳烃受体(AhR)调节剂
NO2694640T3 (fr) * 2011-04-15 2018-03-17
US9175266B2 (en) * 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
MX388871B (es) * 2014-06-27 2025-03-20 Nogra Pharma Ltd Moduladores del receptor arilo y metodos para elaborar y usar los mismos.
EP3193917B9 (fr) * 2014-09-17 2022-02-16 IO Biotech ApS Vaccins comprenants la tryptophane 2,3-dioxygénase (tdo) ou des fragments de la tdo
GB201417369D0 (en) * 2014-10-01 2014-11-12 Redx Pharma Ltd Compounds
CN106860471A (zh) * 2015-12-13 2017-06-20 复旦大学 一种AhR受体蛋白抑制剂在制备抗病毒药物中的用途
US10640499B2 (en) * 2016-09-02 2020-05-05 Gilead Sciences, Inc. Toll like receptor modulator compounds
BR112020004586A2 (pt) * 2017-09-08 2020-09-08 Insignis Therapeutics, Inc. métodos para uso da dipivefrina
CN111166734A (zh) * 2020-02-27 2020-05-19 黄铭 萘醌类物质治疗病原性生物引起的肺炎的用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103169970A (zh) * 2011-12-25 2013-06-26 复旦大学 一种治疗病毒性肺炎的药物组合物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A potential role for AHR in SARS-CoV-2 pathology;F Giovannoni 等;《Research Square》;20200427;第2页"摘要",第2页倒数第1段至第3页第3段,第4页第3段 *
Indoleamine 2,3-Dioxygenase (IDO) Activity During the Primary Immune Response to Influenza Infection Modifies the Memory T Cell Response to Influenza Challenge;Leo K. Sage 等;《VIRAL IMMUNOLOGY》;20141231;摘要,第113页左栏第4段,第115页左栏"结果" *
Murine Coronavirus Infection Activates the Aryl Hydrocarbon Receptor in an Indoleamine 2,3-Dioxygenase-Independent Manner, Contributing to Cytokine Modulation and Proviral TCDD-Inducible-PARP Expression;Matthew E. Grunewald 等;《Journal of Virology》;20200228;摘要,第2页图1说明 *

Also Published As

Publication number Publication date
WO2021253647A1 (fr) 2021-12-23
CN113797337A (zh) 2021-12-17
CN111803635A (zh) 2020-10-23
CN113797337B (zh) 2023-02-07

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