CN111803390A - Hypochlorous acid water nanogel and preparation method thereof - Google Patents
Hypochlorous acid water nanogel and preparation method thereof Download PDFInfo
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- CN111803390A CN111803390A CN202010729988.0A CN202010729988A CN111803390A CN 111803390 A CN111803390 A CN 111803390A CN 202010729988 A CN202010729988 A CN 202010729988A CN 111803390 A CN111803390 A CN 111803390A
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- CN
- China
- Prior art keywords
- hypochlorous acid
- acid water
- nanogel
- glycerol
- trehalose
- Prior art date
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- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 title claims abstract description 120
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 116
- 238000002360 preparation method Methods 0.000 title abstract description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 81
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 28
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 28
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 28
- 239000002994 raw material Substances 0.000 claims abstract description 20
- 238000002791 soaking Methods 0.000 claims abstract description 10
- 238000003756 stirring Methods 0.000 claims abstract description 10
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 21
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 21
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 19
- 229960001631 carbomer Drugs 0.000 claims description 19
- 229920001577 copolymer Polymers 0.000 claims description 15
- 229920000058 polyacrylate Polymers 0.000 claims description 14
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 claims description 10
- 229940104261 taurate Drugs 0.000 claims description 10
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 10
- 239000002537 cosmetic Substances 0.000 claims description 9
- 239000006071 cream Substances 0.000 claims description 9
- 239000003755 preservative agent Substances 0.000 claims description 9
- 239000008367 deionised water Substances 0.000 claims description 8
- 229910021641 deionized water Inorganic materials 0.000 claims description 8
- 230000001954 sterilising effect Effects 0.000 claims description 7
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 230000002335 preservative effect Effects 0.000 claims description 6
- 210000003491 skin Anatomy 0.000 claims description 6
- 241000894006 Bacteria Species 0.000 claims description 3
- 229920006037 cross link polymer Polymers 0.000 claims description 3
- 239000010410 layer Substances 0.000 claims description 3
- 230000004060 metabolic process Effects 0.000 claims description 3
- 239000011241 protective layer Substances 0.000 claims description 3
- 230000008929 regeneration Effects 0.000 claims description 3
- 238000011069 regeneration method Methods 0.000 claims description 3
- 210000004927 skin cell Anatomy 0.000 claims description 3
- FWFUWXVFYKCSQA-UHFFFAOYSA-M sodium;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonate Chemical compound [Na+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C FWFUWXVFYKCSQA-UHFFFAOYSA-M 0.000 claims description 3
- 230000002087 whitening effect Effects 0.000 claims description 3
- BQMNFPBUAQPINY-UHFFFAOYSA-N azane;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonic acid Chemical compound [NH4+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C BQMNFPBUAQPINY-UHFFFAOYSA-N 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 10
- 239000002562 thickening agent Substances 0.000 abstract description 5
- 238000004321 preservation Methods 0.000 abstract description 2
- 230000002035 prolonged effect Effects 0.000 abstract description 2
- 238000002474 experimental method Methods 0.000 description 7
- 238000004659 sterilization and disinfection Methods 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 6
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 5
- 239000000460 chlorine Substances 0.000 description 5
- 229910052801 chlorine Inorganic materials 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 5
- 239000000499 gel Substances 0.000 description 4
- 239000012459 cleaning agent Substances 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 206010067484 Adverse reaction Diseases 0.000 description 2
- 239000004909 Moisturizer Substances 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 230000001333 moisturizer Effects 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 1
- 241000238876 Acari Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- 241000991587 Enterovirus C Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 241001085205 Prenanthella exigua Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical class C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000005415 magnetization Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
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Abstract
The invention discloses hypochlorous acid water nanogel and a preparation method thereof, wherein the hypochlorous acid water nanogel is composed of the following raw materials: hypochlorous acid water, glycerol, trehalose and an auxiliary agent, and the preparation method comprises the following steps: under the condition of low temperature, firstly, performing micromolecular treatment on hypochlorous acid water, adding trehalose, and dissolving for later use; dispersing the thickener with glycerol at low temperature; adding hypochlorous acid water into the thickening agent, and soaking for 5-10 minutes until the hypochlorous acid water is completely soaked; homogenizing for 5min, adding neutralizer, and stirring to obtain hypochlorous acid water nanogel. The hypochlorous acid water is subjected to micromolecular treatment, so that the activity of the hypochlorous acid water is stronger, and the hypochlorous acid water can easily penetrate into the deep layer of the skin to be sterilized and cleaned; the hypochlorous acid water which is unstable and difficult to preserve for a long time is gelatinized, the preservation period of the hypochlorous acid water is prolonged, the use is more convenient, the hypochlorous acid water contained in the gel is slowly released, and the utilization efficiency and the use effect are improved.
Description
Technical Field
The invention relates to the field of hypochlorous acid water preparation, and particularly relates to hypochlorous acid water nanogel and a preparation method thereof.
Background
Hypochlorous acid is oxyacid of chlorine element, has a chemical formula of HClO and a structural formula of H-O-Cl, wherein the valence of the chlorine element is +1 valence, and is the lowest-valence oxyacid of the chlorine element, but the oxidability of the hypochlorous acid is extremely strong in the oxyacid of the chlorine element, and is the second-strong acid oxidized in the oxyacid of the chlorine element, and the hypochlorous acid exists in a solution only, the concentrated solution is yellow, the dilute solution is colorless and extremely unstable, is a very weak acid which is weaker than carbonic acid and is equivalent to hydrogen sulfuric acid, and the hypochlorous acid has the effects of disinfection, cleaning and sterilization, and can be used for cleaning the face and killing mites.
In the prior art, the hypochlorous acid cleaning agent sold in the market is large in bottled amount, and after the hypochlorous acid cleaning agent is used once, the unspent hypochlorous acid cleaning agent is easy to decompose, is difficult to effectively preserve, easily causes unnecessary resource waste, and needs to be further processed.
Disclosure of Invention
In order to solve the problems, the invention aims to provide hypochlorous acid water nanogel and a preparation method thereof.
In order to achieve the above object, the present invention adopts the following aspects
The hypochlorous acid water nanogel is composed of the following raw materials: hypochlorous acid water, glycerol, trehalose and an auxiliary agent.
Preferably, the hypochlorous acid water nanogel is composed of the following raw materials: hypochlorous acid water, glycerol, trehalose, an ammonium acryloyldimethyl taurate/VP copolymer and deionized water.
Preferably, the hypochlorous acid water nanogel consists of the following raw materials in percentage by mass: 95.7% of hypochlorous acid water, 3% of glycerol, 0.5% of trehalose, 0.5% of acryloyl dimethyl taurate/VP copolymer and 0.3% of deionized water.
Preferably, the hypochlorous acid water nanogel is composed of the following raw materials: hypochlorous acid water, glycerol, trehalose, carbome 20 and triethanolamine.
Preferably, the hypochlorous acid water nanogel consists of the following raw materials in percentage by mass: 95.5% of hypochlorous acid water, 3% of glycerol, 0.5% of trehalose, 200.5% of carbomer and 0.5% of triethanolamine.
Preferably, the hypochlorous acid water nanogel is composed of the following raw materials: hypochlorous acid water, glycerol, trehalose, polyacrylate cross-linked polymer-6 and triethanolamine.
Preferably, the hypochlorous acid water nanogel consists of the following raw materials in percentage by mass: 95.5 percent of hypochlorous acid water, 3 percent of glycerol, 0.5 percent of trehalose, 60.5 percent of polyacrylate cross-linked polymer and 0.5 percent of triethanolamine.
The preparation method of the hypochlorous acid water nanogel comprises the following steps:
s1, under the low temperature condition, firstly, performing micromolecular treatment on hypochlorous acid water, then adding trehalose, and dissolving for later use;
s2, dispersing the acryloyl dimethyl ammonium taurate/VP copolymer by using glycerol at low temperature;
s3, adding hypochlorous acid water into the acryloyl dimethyl ammonium taurate/VP copolymer, and soaking for 5-10 minutes until the acryloyl dimethyl ammonium taurate/VP copolymer is completely soaked;
and S4, homogenizing for 5min, adding deionized water, and uniformly stirring to obtain the hypochlorous acid water nanogel.
The preparation method of the hypochlorous acid water nanogel comprises the following steps:
s1, under the low temperature condition, firstly, performing micromolecular treatment on hypochlorous acid water, then adding trehalose, and dissolving for later use;
s2, dispersing carbomer U20 with glycerol at low temperature;
s3, adding hypochlorous acid water into carbomer U20, and soaking for 5-10 minutes until carbomer U20 is completely soaked;
and S4, homogenizing for 5min, adding triethanolamine, and stirring uniformly to obtain the hypochlorous acid water nanogel.
The preparation method of the hypochlorous acid water nanogel comprises the following steps:
s1, under the low temperature condition, firstly, performing micromolecular treatment on hypochlorous acid water, then adding trehalose, and dissolving for later use;
s2, dispersing the polyacrylate cross-linked polymer-6 with glycerol under the low-temperature condition;
s3, adding hypochlorous acid water into the polyacrylate cross-linked polymer-6, and soaking for 5-10 minutes until the polyacrylate cross-linked polymer-6 is completely foamed;
and S4, homogenizing for 5min, adding triethanolamine, and stirring uniformly to obtain the hypochlorous acid water nanogel.
Preferably, the hypochlorous acid water is reduced in molecular weight by subjecting the hypochlorous acid water to a strong magnetization treatment or irradiating the hypochlorous acid water with far infrared rays to split the molecular groups.
The application of the hypochlorous acid water nanogel can be used as a cosmetic raw material to be added into a cream cosmetic, and the hypochlorous acid water nanogel can be used in the cream to play a triple role, namely, sterilization is performed, a protective layer is formed on skin after the hypochlorous acid water nanogel is used, and external bacteria are isolated; whitening, which can accelerate the metabolism of skin cells, rapidly metabolize melanin and promote the regeneration of horny layer; and thirdly, the preservative is replaced, and other preservatives do not need to be added after the preservative is added.
In the invention:
trehalose, a typical stress metabolite, can form a unique protective film on the cell surface under severe environmental conditions such as high temperature, high cold, high osmotic pressure, dry dehydration and the like, and effectively protects the biomolecular structure from being damaged, thereby maintaining the life process and biological characteristics of a living body.
Acryloyl dimethyl ammonium taurate/VP copolymer, english name: arisroflex AVC, a synthetic polymer, is used as a gelling agent for clear systems and as a thickener for oil-in-water emulsions.
Carbomer U20, cross-linked acrylic acid polymer, INCI name Carbomer, foreign trade name Carbopol, carboxyl groups in Carbomer molecules are neutralized and ionized by alkali, negative charges repel each other, molecular chains are dispersed and stretched, and the Carbomer greatly swells to form transparent gel. A small amount of carbomer can enable the system to have good rheological property, and enable the particles or oil drops to be suspended permanently.
Polyacrylate crosslinked polymer-6, abbreviated as ZEN, high molecular polymer, is used as thickener and film-forming agent in cosmetics.
Triethanolamine, TEA for short, is used as an emulsifier, moisturizer, thickener, PH balancer in cosmetics (including skin washes, eye gels, moisturizers, shampoos, etc.). It is used in cosmetic formulations for neutralization with fatty acids to form soaps and with sulfated fatty acids to form amine salts. The triethanolamine is a common emulsifier in cream preparations, and cream products emulsified by the triethanolamine have the characteristics of fine and smooth cream and bright white cream, and in addition, the colloid phase formed by the triethanolamine and higher fatty acid or higher fatty alcohol has good stability, stable product quality and high specific gravity of the added components. Triethanolamine is the most common neutralizer of acidic polymer gel containing carbomer and the like, and forms a stable polymer structure through neutralization with carboxyl of carbomer, so that the application effects of thickening and moisturizing are achieved.
The invention has the beneficial effects that:
the invention carries out micromolecular treatment on the hypochlorous acid water, so that the activity of the hypochlorous acid water is stronger, and the hypochlorous acid water can be easier to go deep into the skin for sterilization and cleaning.
The hypochlorous acid water which is unstable and difficult to preserve for a long time is gelatinized, the preservation period of the hypochlorous acid water is prolonged, the use is more convenient, the hypochlorous acid water contained in the gel is slowly released, and the utilization efficiency and the use effect are improved.
The hypochlorous acid water nanogel can be directly used for cleaning skin, can also be used as a cosmetic raw material to be added into cream cosmetics and used in the cream to play a triple role, and firstly, sterilization is carried out, a protective layer is formed on the skin after the hypochlorous acid water nanogel is used, and external bacteria are isolated; whitening, which can accelerate the metabolism of skin cells, rapidly metabolize melanin and promote the regeneration of horny layer; and thirdly, the preservative is replaced, and other preservatives do not need to be added after the preservative is added.
Detailed Description
In order to make those skilled in the art better understand the technical solutions in the present application, the following will clearly and completely describe the technical solutions in the present application with reference to the embodiments, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and all other embodiments obtained by a person of ordinary skill in the art without making creative efforts based on the embodiments in the present application shall fall within the protection scope of the present application.
Example 1
The hypochlorous acid water nanogel comprises the following raw materials in percentage by mass: 95.7% of hypochlorous acid water, 3% of glycerol, 0.5% of trehalose, 0.5% of acryloyl dimethyl taurate/VP copolymer and 0.3% of deionized water.
The preparation method of the hypochlorous acid water nanogel comprises the following steps:
s1, under the low temperature condition, firstly, performing micromolecular treatment on hypochlorous acid water, then adding trehalose, and dissolving for later use;
s2, dispersing the acryloyl dimethyl ammonium taurate/VP copolymer by using glycerol at low temperature;
s3, adding hypochlorous acid water into the acryloyl dimethyl ammonium taurate/VP copolymer, and soaking for 5-10 minutes until the acryloyl dimethyl ammonium taurate/VP copolymer is completely soaked;
and S4, homogenizing for 5min, adding deionized water, and uniformly stirring to obtain the hypochlorous acid water nanogel.
Example 2
The composite material consists of the following raw materials in percentage by mass: 95.5% of hypochlorous acid water, 3% of glycerol, 0.5% of trehalose, 200.5% of carbomer and 0.5% of triethanolamine.
The preparation method of the hypochlorous acid water nanogel comprises the following steps:
s1, under the low temperature condition, firstly, performing micromolecular treatment on hypochlorous acid water, then adding trehalose, and dissolving for later use;
s2, dispersing carbomer U20 with glycerol at low temperature;
s3, adding hypochlorous acid water into carbomer U20, and soaking for 5-10 minutes until carbomer U20 is completely soaked;
and S4, homogenizing for 5min, adding triethanolamine, and stirring uniformly to obtain the hypochlorous acid water nanogel.
Example 3
The hypochlorous acid water nanogel comprises the following raw materials in percentage by mass: 95.5 percent of hypochlorous acid water, 3 percent of glycerol, 0.5 percent of trehalose, 60.5 percent of polyacrylate cross-linked polymer and 0.5 percent of triethanolamine.
The preparation method of the hypochlorous acid water nanogel comprises the following steps:
s1, under the low temperature condition, firstly, performing micromolecular treatment on hypochlorous acid water, then adding trehalose, and dissolving for later use;
s2, dispersing the polyacrylate cross-linked polymer-6 with glycerol under the low-temperature condition;
s3, adding hypochlorous acid water into the polyacrylate cross-linked polymer-6, and soaking for 5-10 minutes until the polyacrylate cross-linked polymer-6 is completely foamed;
and S4, homogenizing for 5min, adding triethanolamine, and stirring uniformly to obtain the hypochlorous acid water nanogel.
Experimental example 1
Safety and toxicology experiments
Experiment 1: the experimental mice are divided into three groups, five mice are used in each group, the hypochlorous acid water nanogel prepared in the embodiment 1-3 is smeared on an experimental block on the back of the experimental mouse, the hair is removed, the experiment is carried out twice a day, the hypochlorous acid water nanogel is kept on the experimental part for at least ten minutes each time, the experiment is continuously carried out for 10 days, and whether the surface of the experimental part of the experimental mouse has abnormity or abnormal conditions is observed.
Experiment 2: the experimental mice were divided into three groups of five mice each, and the hypochlorous acid water nanogel prepared in examples 1 to 3 was intragastrically administered to the experimental mice once every three days for three consecutive experiments, and the experimental mice were observed for adverse reactions or death. The results are shown in Table 1.
TABLE 1
As can be seen from the experimental data in Table 1, the hypochlorous acid water nanogel prepared by the method has no obvious adverse effect on experimental animals, so that the method is determined to have no adverse reaction or weak adverse reaction, and the use safety is guaranteed.
Experimental example two
Experiment of bactericidal Effect
The hypochlorous acid water nanogels prepared in examples 1 to 3 were subjected to a sterilization effect test, and the sterilization effects were respectively tested by using staphylococcus aureus, colibacillus, candida albicans, bacillus subtilis var niger and poliovirus as examples.
Selecting ten sterile wet tissues, dividing the sterile wet tissues into two groups, respectively dripping five viruses with certain concentrations, then simply cleaning one group, smearing hypochlorous acid water nanogel on all the wet tissues, and sampling at different time points after smearing to detect the virus content.
Table 2 shows experimental data of the hypochlorous acid water nanogel prepared in example 1, table 3 shows experimental data of the hypochlorous acid water nanogel prepared in example 2, and table 4 shows experimental data of the hypochlorous acid water nanogel prepared in example 3.
TABLE 2
TABLE 3
TABLE 4
As can be seen from the experimental data in tables 2, 3 and 4, the bactericidal effect of the hypochlorous acid water nanogel prepared by the invention reaches or even exceeds the national requirement on the effect of the hypochlorous acid water on killing microorganisms.
Finally, the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting, and other modifications or equivalent substitutions made by the technical solutions of the present invention by those of ordinary skill in the art should be covered within the scope of the claims of the present invention as long as they do not depart from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. The hypochlorous acid water nanogel is characterized by consisting of the following raw materials:
hypochlorous acid water, glycerol, trehalose and an auxiliary agent.
2. The hypochlorous acid water nanogel of claim 1, comprising the following raw materials: hypochlorous acid water, glycerol, trehalose, an ammonium acryloyldimethyl taurate/VP copolymer and deionized water.
3. The hypochlorous acid water nanogel of claim 2, which consists of the following raw materials in percentage by mass: 95.7% of hypochlorous acid water, 3% of glycerol, 0.5% of trehalose, 0.5% of acryloyl dimethyl taurate/VP copolymer and 0.3% of deionized water.
4. The hypochlorous acid water nanogel of claim 1, comprising the following raw materials: hypochlorous acid water, glycerol, trehalose, carbome 20 and triethanolamine.
5. The hypochlorous acid water nanogel of claim 4, which consists of the following raw materials in percentage by mass: 95.5% of hypochlorous acid water, 3% of glycerol, 0.5% of trehalose, 200.5% of carbomer and 0.5% of triethanolamine.
6. The hypochlorous acid water nanogel of claim 1, which consists of the following raw materials in percentage by mass: 95.5 percent of hypochlorous acid water, 3 percent of glycerol, 0.5 percent of trehalose, 60.5 percent of polyacrylate cross-linked polymer and 0.5 percent of triethanolamine.
7. The method of preparing a nanogel of hypochlorous acid as defined in claim 2, comprising the steps of:
s1, under the low temperature condition, firstly, performing micromolecular treatment on hypochlorous acid water, then adding trehalose, and dissolving for later use;
s2, dispersing the acryloyl dimethyl ammonium taurate/VP copolymer by using glycerol at low temperature;
s3, adding hypochlorous acid water into the acryloyl dimethyl ammonium taurate/VP copolymer, and soaking for 5-10 minutes until the acryloyl dimethyl ammonium taurate/VP copolymer is completely soaked;
and S4, homogenizing for 5min, adding deionized water, and uniformly stirring to obtain the hypochlorous acid water nanogel.
8. The method of preparing a nanogel of hypochlorous acid as defined in claim 4, comprising the steps of:
s1, under the low temperature condition, firstly, performing micromolecular treatment on hypochlorous acid water, then adding trehalose, and dissolving for later use;
s2, dispersing carbomer U20 with glycerol at low temperature;
s3, adding hypochlorous acid water into carbomer U20, and soaking for 5-10 minutes until carbomer U20 is completely soaked;
and S4, homogenizing for 5min, adding triethanolamine, and stirring uniformly to obtain the hypochlorous acid water nanogel.
9. The method of preparing a nanogel of hypochlorous acid as defined in claim 6, comprising the steps of:
s1, under the low temperature condition, firstly, performing micromolecular treatment on hypochlorous acid water, then adding trehalose, and dissolving for later use;
s2, dispersing the polyacrylate cross-linked polymer-6 with glycerol under the low-temperature condition;
s3, adding hypochlorous acid water into the polyacrylate cross-linked polymer-6, and soaking for 5-10 minutes until the polyacrylate cross-linked polymer-6 is completely foamed;
and S4, homogenizing for 5min, adding triethanolamine, and stirring uniformly to obtain the hypochlorous acid water nanogel.
10. The use of the hypochlorous acid aqueous nanogel according to claim 1, wherein the hypochlorous acid aqueous nanogel is used as a cosmetic raw material added to a cream cosmetic to play a triple role in sterilizing, forming a protective layer on the skin after use to isolate external bacteria; whitening, which can accelerate the metabolism of skin cells, rapidly metabolize melanin and promote the regeneration of horny layer; and thirdly, the preservative is replaced, and other preservatives do not need to be added after the preservative is added.
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