CN111803067B - Animal magnetic resonance imaging eye protection device and use method - Google Patents
Animal magnetic resonance imaging eye protection device and use method Download PDFInfo
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- CN111803067B CN111803067B CN202010100174.0A CN202010100174A CN111803067B CN 111803067 B CN111803067 B CN 111803067B CN 202010100174 A CN202010100174 A CN 202010100174A CN 111803067 B CN111803067 B CN 111803067B
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- 241001465754 Metazoa Species 0.000 title claims abstract description 70
- 238000002595 magnetic resonance imaging Methods 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 title claims abstract description 17
- 210000003128 head Anatomy 0.000 claims abstract description 60
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 230000005540 biological transmission Effects 0.000 claims abstract description 25
- 229920000742 Cotton Polymers 0.000 claims abstract description 16
- 230000007246 mechanism Effects 0.000 claims abstract description 8
- 238000010171 animal model Methods 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims description 25
- 239000003889 eye drop Substances 0.000 claims description 8
- 229940012356 eye drops Drugs 0.000 claims description 8
- 239000002504 physiological saline solution Substances 0.000 claims description 8
- 230000009471 action Effects 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 238000009736 wetting Methods 0.000 claims description 2
- 201000004569 Blindness Diseases 0.000 abstract description 8
- 239000007789 gas Substances 0.000 description 23
- 230000008569 process Effects 0.000 description 9
- 239000007924 injection Substances 0.000 description 8
- 238000002347 injection Methods 0.000 description 8
- 238000003384 imaging method Methods 0.000 description 7
- 238000011160 research Methods 0.000 description 4
- 206010002091 Anaesthesia Diseases 0.000 description 3
- 230000037005 anaesthesia Effects 0.000 description 3
- 230000003444 anaesthetic effect Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- NMFHJNAPXOMSRX-PUPDPRJKSA-N [(1r)-3-(3,4-dimethoxyphenyl)-1-[3-(2-morpholin-4-ylethoxy)phenyl]propyl] (2s)-1-[(2s)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate Chemical compound C([C@@H](OC(=O)[C@@H]1CCCCN1C(=O)[C@@H](CC)C=1C=C(OC)C(OC)=C(OC)C=1)C=1C=C(OCCN2CCOCC2)C=CC=1)CC1=CC=C(OC)C(OC)=C1 NMFHJNAPXOMSRX-PUPDPRJKSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 1
- 206010013774 Dry eye Diseases 0.000 description 1
- 101100330193 Homo sapiens CYREN gene Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 230000036982 action potential Effects 0.000 description 1
- 239000003994 anesthetic gas Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
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- 239000003814 drug Substances 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000005389 magnetism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000001012 protector Effects 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/40—Animals
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- High Energy & Nuclear Physics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Radiology & Medical Imaging (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
The invention provides an animal magnetic resonance imaging eye protection device and a use method thereof, wherein the eye protection device comprises two conical eye shields, a connecting mechanism fixed with the head of an animal is arranged on the two conical eye shields, a cotton gauze is arranged in the conical eye shields, a pressure type nozzle facing the cotton gauze is arranged at the top of the conical eye shields, the pressure type nozzle is connected with a gas transmission assembly, the gas transmission assembly comprises a first gas transmission pipe, one end of the first gas transmission pipe is connected with two second gas transmission pipes, the other end of the first gas transmission pipe is connected with an air filling device, the second gas transmission pipe is connected with the pressure type nozzle, and a water filling port is arranged on the first gas transmission pipe. The invention can prevent the blindness of eyes of experimental animals, can be repeatedly used, is simple to operate, and does not influence the omnibearing examination of the heads, the bodies and the like of the animals.
Description
Technical Field
The invention relates to the technical field of magnetic resonance imaging instruments, in particular to an animal magnetic resonance imaging eye protection device and a using method thereof.
Background
Magnetic resonance imaging (Magnetic Resonance Imaging, MRI) has been widely used in preclinical research and medical diagnostics. Animals are widely used in imaging experimental research as a model animal for preclinical research. The MRI imaging is carried out on the premise that the checked part does not macroscopically move or is static, and the animal MRI is the biggest difference from the human MRI check that the animal does not cooperate with the check or the experimenter and keeps a body position still. Therefore, in the animal magnetic resonance imaging experiment, the anesthetic is generally injected first or the anesthetic device continuously breathes the animal into the anesthetic gas mixed with oxygen, and the animal performs a series of imaging scans under the deep anesthesia state, so that the imaging time is longer, and the imaging lasts for one to two hours or even longer.
The anesthetic blocks the motor nerve fibers of skeletal muscles and diaphragm muscles, action potential can not be transmitted downwards, nerve impulses of receptors, effectors and the like of the cornea are blocked, and after the animal is anesthetized, the eyelid of the eye is not closed and is always opened. The magnetic resonance imaging magnet room is relatively dry and well ventilated, and the eyes of animals are dry for a long time, so that eye diseases and even blindness of eyes can be induced. However, in order to observe the occurrence and development processes of the diseases, the modeling process of the model animal needs to repeatedly perform magnetic resonance imaging scanning at different time points, and if the eyes of the animal are ill or blind, diet, emotion and the like of the animal are affected, which is not beneficial to the successful establishment and further long-term tracking research of a specific disease model.
The animal should take eye protection measures during the magnetic resonance imaging process, but the animal is positioned in the center of a strong magnetic field, which is unfavorable for the conventional protection measures. If the scanning bed is withdrawn after one examination is completed, and the next scanning is performed after the protective measures are applied, the scanning bed needs to be repositioned in and out, so that the experimental process is influenced, the layer position and direction of the same examination position before and after the animal are difficult to ensure to be consistent, and the later image comparison is not facilitated.
At present, the risk of blindness of eyes of animals is basically not considered or measures are taken in the magnetic resonance imaging experiment of animals, but the protection measures are complex and wrap the whole head area, so that the head-related examination is not facilitated.
Disclosure of Invention
Aiming at the problems existing in the animal magnetic resonance imaging experimental process and the defects existing in the prior art, the invention provides the animal magnetic resonance imaging eye protection device and the application method thereof, which can be repeatedly used while preventing the blindness of eyes of experimental animals, are simple to operate, and do not influence the head, body and other omnibearing examination of the animals.
The technical scheme of the invention is realized as follows: the utility model provides an animal magnetic resonance imaging eye protector, including two conical eye-pieces, be provided with the coupling mechanism fixed with animal head on two conical eye-pieces, be provided with cotton gauze in the conical eye-piece, the top of conical eye-piece is provided with the pressure type nozzle towards cotton gauze, pressure type nozzle links to each other with the gas transmission subassembly, the gas transmission subassembly includes first gas-supply pipe, the one end of first gas-supply pipe is connected with two second gas-supply pipes, the other end links to each other with the air entrainment device, the second conveyer pipe links to each other with pressure type nozzle, be provided with the water filling port on the first gas-supply pipe.
Further, the water injection port is located at a position, close to the second gas delivery pipe, of the first gas delivery pipe, a first one-way valve is arranged on the first gas delivery pipe between the water injection port and the gas filling device and used for controlling gas to flow towards the water injection port, a second one-way valve is arranged on the first gas delivery pipe between the water injection port and the first one-way valve and used for controlling gas and liquid to flow towards the conical eyeshade.
Further, the connecting mechanism comprises a back head belt, a front head belt and a chin belt, wherein two ends of the back head belt are respectively connected with the two conical eyeshields, one ends of the front head belt and the chin belt are respectively connected with one conical eyeshield, the other ends of the front head belt and the chin belt are free ends, two hanging rings are arranged on the other conical eyeshield, and the free ends of the front head belt and the chin belt are respectively connected with the hanging rings.
Further, the top of conical eye-shade is provided with the receiver, and second conveyer pipe and pressure type nozzle pass through the receiver and link to each other, and the tip of area links to each other with the lateral wall of receiver behind the head, and the one end of area before the head and chin area all links to each other with the lateral wall of a receiver, and two links are all fixed in on the lateral wall of another receiver.
Further, a sealing cover is arranged at the water injection port.
Further, the back head strap, the front head strap and the chin strap are all elastic fixing straps.
Further, the distance between the cotton gauze and the opening end of the conical eyeshade is 3mm.
Further, the air-adding device is a hand-held air bag.
The application method of the animal magnetic resonance imaging eye protection device comprises the following steps:
(1) Before the magnetic resonance scanning starts, physiological saline or eyedrops are filled through a water filling port of the first gas transmission pipe, and the water filling port is sealed;
(2) Fixing an experimental animal on a magnetic resonance scanning bed, then respectively covering two eyes of the animal by two conical eye shields, arranging a head rear belt behind the head of the animal, arranging a head front belt in front of the head of the animal, connecting a hanging ring with a chin belt at the chin of the animal, connecting the chin belt with the other hanging ring, and fixing the conical eye shields on the head of the animal;
(3) The air-entraining device is used for inflating the first air conveying pipe, and physiological saline or eyedrops are uniformly sprayed on the cotton gauze arranged in the conical eyeshade under the action of air pressure through the pressure nozzle, so that a moist environment is provided for the surroundings of eyes of animals.
The invention has the beneficial effects that:
The working principle of the invention is as follows: the air-entrapping device is inflated to generate pressure, the physiological saline or eyedrops are pressurized through the first one-way valve and the second one-way valve, the physiological saline or eyedrops are forced to be ejected through the pressure type nozzle by air pressure, cotton gauze which is evenly sprayed in the eyeshade provides a moist environment for animal eyes, and blindness caused by dry eyes in a long-time imaging acquisition process under an animal anesthesia state is prevented.
The invention aims at preventing the blindness of eyes of experimental animals, designs the animal magnetic resonance imaging eye protection device on the basis of not influencing the magnetic resonance experimental process, controls the spraying time and the spraying quantity by an inspector, keeps the eyes of the animals moist, has simple operation and low cost, does not influence the head, body and other omnibearing inspection of the animals, and can be suitable for rabbits, rodents, primates and other large animals.
The animal magnetic resonance imaging eye protection device has the advantages of simple structure, low cost, convenient use, no need of entering and exiting a scanning bed, repeated use, no direct spraying of sprayed liquid onto animal eyes, no introduction of motion artifacts caused by local motion of the head and the like due to animal stimulation, effective prevention of the risk of animal blindness in the long-term experiment process, and no influence on the omnibearing MRI examination of the head, the body and the like of the animal.
Drawings
In order to more clearly illustrate the embodiments of the invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of the structure of the present invention;
FIG. 2 is a schematic view of the structure of a conical eye shield;
Fig. 3 is a schematic structural view of the liquid storage box.
Conical eye shade 1, cotton gauze 2, back of head area 3, front of head area 4, chin area 5, no magnetism couple 6, link 7, pressure nozzle 8, first gas-supply pipe 9, second gas-supply pipe 10, air entrainment device 11, water injection mouth 12, sealed lid 13, first check valve 14, second check valve 15, reservoir 16.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without any inventive effort, are intended to be within the scope of the invention.
Example 1
As shown in fig. 1-2, an animal magnetic resonance imaging eye protection device comprises two conical eyepieces 1, wherein the conical eyepieces 1 are of conical hard non-magnetic plastic structures, a layer of cotton gauze 2 is arranged in each conical eyepiece 1, the distance between the cotton gauze 2 and the opening end of each conical eyepiece 1 is 3mm, and liquid is prevented from being directly dripped on animal eyes to stimulate the eyes, so that the animal eyes are uncomfortable to move locally.
The two conical eyeshade 1 are provided with a connecting mechanism fixed with the head of an animal, the connecting mechanism comprises a head rear belt 3, a head front belt 4 and a chin belt 5, the head rear belt 3, the head front belt 4 and the chin belt 5 are elastic fixing belts, two ends of the head rear belt 3 are respectively connected with the two conical eyeshades 1, one ends of the head front belt 4 and the chin belt 5 are respectively connected with the conical eyeshade 1, the other ends are free ends, a non-magnetic hook 6 is fixed on the other conical eyeshade 1, two hanging rings 7 are arranged on the other conical eyeshade 1, and the free ends of the head front belt 4 and the chin belt 5 are respectively connected with the corresponding hanging rings 7. The back head belt 3 is used for connecting and fixing two conical eyeshades 1, and is positioned behind the head when in use; the head front belt 4 is used for fixing the conical eye cover 1, and is connected with a hanging ring 7 through a non-magnetic hanging hook 6 by bypassing the front of the head of an animal when in use, the chin belt 5 is used for fixing the eye cover, and is connected with the hanging ring 7 on the other side through the non-magnetic hanging hook 6 by bypassing the chin of the animal when in use.
The top of the conical eye shield 1 is provided with a pressure type nozzle 8, the liquid outlet end of the pressure type nozzle 8 is opposite to the cotton gauze 2, the liquid inlet end of the pressure type nozzle 8 is connected with a gas transmission assembly, the gas transmission assembly comprises a first gas transmission pipe 9, one end of the first gas transmission pipe 9 is connected with two second gas transmission pipes 10, the other end of the first gas transmission pipe is connected with an air adding device 11, and the air adding device 11 is a hand-held air bag. The first air pipe 9 and the two second air pipes 10 form a Y-shaped air pipe, the second air pipe is connected with the liquid inlet end of the pressure nozzle 8, the first air pipe is provided with a water filling port 12, and a sealing cover 13 is arranged at the water filling port 12.
The water filling port 12 is located at the position of the first gas pipe 9, which is close to the second gas pipe 10, a first one-way valve 14 is arranged on the first gas pipe 9 between the water filling port 12 and the gas filling device 11, the first one-way valve 14 is used for controlling gas to flow towards the water filling port 12, a second one-way valve 15 is arranged on the first gas pipe 9 between the water filling port 12 and the first one-way valve 14, and the second one-way valve 15 is used for controlling gas and liquid to flow towards the conical eyeshade 1.
Example two
This embodiment is substantially the same as the first embodiment except that: as shown in fig. 1 and 3, the top of the conical eye shield 1 is sleeved with a liquid storage box 16, a liquid outlet of the second conveying pipe is connected with the upper end of the liquid storage box 16, a liquid inlet of the pressure type nozzle 8 is connected with the lower end of the liquid storage box 16, and the second conveying pipe is communicated with the pressure type nozzle 8 through the liquid storage box 16. The two ends of the back head belt 3 are respectively connected with the side walls of the corresponding liquid storage boxes 16, one ends of the front head belt 4 and the chin belt 5 are connected with the side wall of one liquid storage box 16, and the two hanging rings 7 are fixed on the side wall of the other liquid storage box 16. The liquid storage box 16 is added, so that the storage amount of liquid medicine in the air delivery assembly is improved, and the connection mechanism and the eyeshade are convenient to connect.
Example III
The method for using the animal magnetic resonance imaging eye protection device according to the first embodiment and the second embodiment comprises the following steps:
(1) Before the magnetic resonance scanning starts, physiological saline or eyedrops are filled into the first air delivery pipe 9 and the second air delivery pipe 10 through the water injection port 12 of the first air delivery pipe 9, and the water injection port 12 is sealed;
(2) Fixing an experimental animal on a magnetic resonance scanning bed, then respectively covering eyes of the animal by two conical eye shields 1, arranging a head rear belt 3 behind the head of the animal, arranging a head front belt 4 in front of the head of the animal, connecting a hanging ring 7, arranging a chin belt 5 at the chin of the animal, connecting the chin belt 5 with the other hanging ring 7, and fixing the conical eye shields 1 on the head of the animal;
(3) The first check valve 14 and the second check valve 15 are opened, the hand-held air bag is manually pressed, air enters the first air pipe 9 through the first check valve 14, physiological saline or eyedrops in the first air pipe 9 and the second air pipe 10 are uniformly sprayed on the cotton gauze 2 arranged in the conical eye cover 1 through the pressure nozzle 8 under the action of air pressure, a wetting environment is provided for the periphery of eyes of an animal, and blindness caused by dryness of the eyes in the long-time imaging acquisition process under the anesthesia state of the animal is prevented.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
Claims (3)
1. An animal magnetic resonance imaging eye protection device, characterized in that: the device comprises two conical eyepieces (1), wherein a connecting mechanism fixed with the head of an animal is arranged on the two conical eyepieces (1), a cotton gauze (2) is arranged in the conical eyepieces (1), a pressure type nozzle (8) facing the cotton gauze (2) is arranged at the top of the conical eyepieces (1), the pressure type nozzle (8) is connected with a gas transmission assembly, the gas transmission assembly comprises a first gas transmission pipe (9), one end of the first gas transmission pipe (9) is connected with two second gas transmission pipes (10), the other end of the first gas transmission pipe is connected with an air filling device (11), the second gas transmission pipe (10) is connected with the pressure type nozzle (8), and a water filling port (12) is arranged on the first gas transmission pipe (9);
The water filling port (12) is positioned at the position, close to the second air conveying pipe (10), of the first air conveying pipe (9), a first one-way valve (14) is arranged on the first air conveying pipe (9) between the water filling port (12) and the air filling device (11), the first one-way valve (14) is used for controlling air to flow towards the water filling port (12), a second one-way valve (15) is arranged on the first air conveying pipe (9) between the water filling port (12) and the first one-way valve (14), and the second one-way valve (15) is used for controlling air and liquid to flow towards the conical eyeshade (1);
The connecting mechanism comprises a back head belt (3), a front head belt (4) and a chin belt (5), wherein two ends of the back head belt (3) are respectively connected with two conical eyeshields (1), one ends of the front head belt (4) and the chin belt (5) are connected with one conical eyeshield (1), the other ends are free ends, two hanging rings (7) are arranged on the other conical eyeshield (1), and the free ends of the front head belt (4) and the chin belt (5) are respectively connected with the hanging rings (7);
The top of the conical eye cover (1) is provided with a liquid storage box (16), the second air pipe (10) is connected with the pressure type nozzle (8) through the liquid storage box (16), the end part of the head rear belt (3) is connected with the side wall of the liquid storage box (16), one end of the head front belt (4) and one end of the chin belt (5) are connected with the side wall of one liquid storage box (16), and the two hanging rings (7) are fixed on the side wall of the other liquid storage box (16);
the air-entraining device (11) is a hand-held air bag;
a sealing cover (13) is arranged at the water filling port (12);
The distance between the cotton gauze (2) and the opening end of the conical eyeshade (1) is 3mm.
2. An animal magnetic resonance imaging eye protection device according to claim 1, wherein: the back head belt (3), the front head belt (4) and the chin belt (5) are all elastic fixing belts.
3. A method of using an animal magnetic resonance imaging eye protection device according to claim 1 or 2, comprising the steps of:
(1) Before the magnetic resonance scanning starts, physiological saline or eyedrops are filled through a water filling port (12) of the first gas pipe (9) and the water filling port (12) is sealed;
(2) Fixing an experimental animal on a magnetic resonance scanning bed, then respectively covering two eyes of the animal by two conical eye shields (1), arranging a head back belt (3) behind the head of the animal, arranging a head front belt (4) in front of the head of the animal and connecting with a hanging ring (7), arranging a chin belt (5) at the chin of the animal and connecting with the other hanging ring (7), and fixing the conical eye shields (1) on the head of the animal;
(3) The air-entraining device (11) is used for inflating the first air conveying pipe (9), and physiological saline or eyedrops are uniformly sprayed on the cotton gauze (2) arranged in the conical eyeshade (1) through the pressure nozzle (8) under the action of air pressure, so as to provide a wetting environment for the surroundings of eyes of animals.
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| CN103598946A (en) * | 2013-03-14 | 2014-02-26 | 孙其刚 | Eye enlarging instrument |
| CN103462789A (en) * | 2013-09-16 | 2013-12-25 | 黄廷球 | Acupoint massage health care instrument |
| CN205163374U (en) * | 2015-11-26 | 2016-04-20 | 丹阳市职业技术教育中心 | Ware is treated to manual near -sighted intraocular pressure |
| CN205814528U (en) * | 2016-04-27 | 2016-12-21 | 惠春艳 | A kind of atomization safety goggles |
| JP3206781U (en) * | 2016-07-14 | 2016-10-06 | 望宇 津田 | Eye pressure reduction / decompression device |
| CN208274677U (en) * | 2017-08-17 | 2018-12-25 | 芜湖市第二人民医院 | Newborn's anti-dropout eye protection cover |
| CN208659690U (en) * | 2017-12-18 | 2019-03-29 | 无锡市人民医院 | Disposable sleep aids for patients with hyperthyroidism and exophthalmos |
| CN208659684U (en) * | 2017-12-26 | 2019-03-29 | 王秀芝 | A kind of novel ophthalmology eye drop device |
| CN110664407A (en) * | 2019-09-19 | 2020-01-10 | 哈尔滨医科大学 | A kind of protective device for magnetic resonance imaging to prevent blindness in rabbits and using method |
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