CN111603429A - Traditional Chinese medicine skin care lotion with whitening and freckle removing effects and preparation method thereof - Google Patents
Traditional Chinese medicine skin care lotion with whitening and freckle removing effects and preparation method thereof Download PDFInfo
- Publication number
- CN111603429A CN111603429A CN202010527680.8A CN202010527680A CN111603429A CN 111603429 A CN111603429 A CN 111603429A CN 202010527680 A CN202010527680 A CN 202010527680A CN 111603429 A CN111603429 A CN 111603429A
- Authority
- CN
- China
- Prior art keywords
- extract
- chinese medicine
- percent
- traditional chinese
- skin care
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 44
- 230000000694 effects Effects 0.000 title claims abstract description 26
- 208000003351 Melanosis Diseases 0.000 title claims abstract description 23
- 239000006210 lotion Substances 0.000 title claims abstract description 22
- 230000002087 whitening effect Effects 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000000284 extract Substances 0.000 claims description 100
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 66
- 238000001914 filtration Methods 0.000 claims description 32
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 26
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims description 19
- 235000006226 Areca catechu Nutrition 0.000 claims description 18
- 239000004166 Lanolin Substances 0.000 claims description 18
- 229940039717 lanolin Drugs 0.000 claims description 18
- 235000019388 lanolin Nutrition 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 16
- 244000197580 Poria cocos Species 0.000 claims description 15
- 235000008599 Poria cocos Nutrition 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 15
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 14
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 14
- 238000010828 elution Methods 0.000 claims description 14
- 241000209035 Ilex Species 0.000 claims description 13
- 235000003332 Ilex aquifolium Nutrition 0.000 claims description 13
- 235000002296 Ilex sandwicensis Nutrition 0.000 claims description 13
- 235000002294 Ilex volkensiana Nutrition 0.000 claims description 13
- 240000005790 Oroxylum indicum Species 0.000 claims description 13
- 235000012920 Oroxylum indicum Nutrition 0.000 claims description 13
- 238000001179 sorption measurement Methods 0.000 claims description 13
- 240000005067 Jasminum grandiflorum Species 0.000 claims description 12
- 235000004412 Jasminum grandiflorum Nutrition 0.000 claims description 12
- 241000213006 Angelica dahurica Species 0.000 claims description 10
- 241000512259 Ascophyllum nodosum Species 0.000 claims description 10
- 241000705930 Broussonetia papyrifera Species 0.000 claims description 10
- 206010014970 Ephelides Diseases 0.000 claims description 10
- 244000207740 Lemna minor Species 0.000 claims description 10
- 235000006439 Lemna minor Nutrition 0.000 claims description 10
- 240000003915 Lophatherum gracile Species 0.000 claims description 10
- 235000001855 Portulaca oleracea Nutrition 0.000 claims description 10
- 244000144730 Amygdalus persica Species 0.000 claims description 9
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 claims description 9
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 9
- 241000737253 Lygodium japonicum Species 0.000 claims description 9
- 235000006040 Prunus persica var persica Nutrition 0.000 claims description 9
- 239000001168 astaxanthin Substances 0.000 claims description 9
- 235000013793 astaxanthin Nutrition 0.000 claims description 9
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims description 9
- 229940022405 astaxanthin Drugs 0.000 claims description 9
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 9
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 9
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 9
- 239000011347 resin Substances 0.000 claims description 9
- 229920005989 resin Polymers 0.000 claims description 9
- 229940042585 tocopherol acetate Drugs 0.000 claims description 9
- 244000235603 Acacia catechu Species 0.000 claims description 8
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 235000011477 liquorice Nutrition 0.000 claims description 8
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 8
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 8
- 238000000108 ultra-filtration Methods 0.000 claims description 8
- 241001116389 Aloe Species 0.000 claims description 7
- 235000011399 aloe vera Nutrition 0.000 claims description 7
- 239000008367 deionised water Substances 0.000 claims description 7
- 229910021641 deionized water Inorganic materials 0.000 claims description 7
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 6
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 6
- 238000004140 cleaning Methods 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 6
- 239000012535 impurity Substances 0.000 claims description 6
- 229940010454 licorice Drugs 0.000 claims description 6
- 238000002791 soaking Methods 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 4
- 229960005150 glycerol Drugs 0.000 claims description 3
- 229960004063 propylene glycol Drugs 0.000 claims description 3
- 241000207840 Jasminum Species 0.000 claims description 2
- 235000010254 Jasminum officinale Nutrition 0.000 claims description 2
- 230000032683 aging Effects 0.000 claims description 2
- 241000490229 Eucephalus Species 0.000 claims 2
- 239000000306 component Substances 0.000 claims 2
- 239000008358 core component Substances 0.000 claims 1
- 229960004756 ethanol Drugs 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 abstract description 4
- 239000004909 Moisturizer Substances 0.000 abstract description 3
- 230000001333 moisturizer Effects 0.000 abstract description 3
- 229930003935 flavonoid Natural products 0.000 abstract description 2
- 150000002215 flavonoids Chemical class 0.000 abstract description 2
- 235000017173 flavonoids Nutrition 0.000 abstract description 2
- 150000004676 glycans Chemical class 0.000 abstract description 2
- 150000002989 phenols Chemical class 0.000 abstract description 2
- 229920001282 polysaccharide Polymers 0.000 abstract description 2
- 239000005017 polysaccharide Substances 0.000 abstract description 2
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 150000008130 triterpenoid saponins Chemical class 0.000 abstract 1
- 239000000341 volatile oil Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 50
- 210000003491 skin Anatomy 0.000 description 37
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 30
- 235000019441 ethanol Nutrition 0.000 description 18
- 241000628997 Flos Species 0.000 description 12
- 102000003425 Tyrosinase Human genes 0.000 description 11
- 108060008724 Tyrosinase Proteins 0.000 description 11
- 244000080767 Areca catechu Species 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 10
- 238000012360 testing method Methods 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 238000005303 weighing Methods 0.000 description 8
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 7
- 244000097654 Cudrania tricuspidata Species 0.000 description 6
- 235000010918 Cudrania tricuspidata Nutrition 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 6
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 6
- 239000002953 phosphate buffered saline Substances 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 5
- -1 superoxide ion Chemical class 0.000 description 5
- 240000000249 Morus alba Species 0.000 description 4
- 235000008708 Morus alba Nutrition 0.000 description 4
- 235000001188 Peltandra virginica Nutrition 0.000 description 4
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 4
- 230000003796 beauty Effects 0.000 description 4
- 239000003480 eluent Substances 0.000 description 4
- 239000012467 final product Substances 0.000 description 4
- 238000002372 labelling Methods 0.000 description 4
- 238000005374 membrane filtration Methods 0.000 description 4
- 210000000582 semen Anatomy 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 235000008216 herbs Nutrition 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000009759 skin aging Effects 0.000 description 3
- 150000003648 triterpenes Chemical class 0.000 description 3
- 206010002198 Anaphylactic reaction Diseases 0.000 description 2
- 206010008570 Chloasma Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 2
- 208000012641 Pigmentation disease Diseases 0.000 description 2
- 208000003455 anaphylaxis Diseases 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 210000002752 melanocyte Anatomy 0.000 description 2
- 230000003061 melanogenesis Effects 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 241001662414 Aster tataricus Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 230000002292 Radical scavenging effect Effects 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 229960000271 arbutin Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003851 biochemical process Effects 0.000 description 1
- 239000003157 biological pigment Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 210000001787 dendrite Anatomy 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- MGJZITXUQXWAKY-UHFFFAOYSA-N diphenyl-(2,4,6-trinitrophenyl)iminoazanium Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1N=[N+](C=1C=CC=CC=1)C1=CC=CC=C1 MGJZITXUQXWAKY-UHFFFAOYSA-N 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 210000005175 epidermal keratinocyte Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- OLOOJGVNMBJLLR-UHFFFAOYSA-N imperatorin Chemical compound C1=CC(=O)OC2=C1C=C1C=COC1=C2OCC=C(C)C OLOOJGVNMBJLLR-UHFFFAOYSA-N 0.000 description 1
- XKVWLLRDBHAWBL-UHFFFAOYSA-N imperatorin Natural products CC(=CCOc1c2OCCc2cc3C=CC(=O)Oc13)C XKVWLLRDBHAWBL-UHFFFAOYSA-N 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 235000017709 saponins Nutrition 0.000 description 1
- 239000009910 sargent gloryvine Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine skin moisturizer with whitening and freckle removing effects and a preparation method thereof. The skin care lotion is rich in active ingredients with whitening and freckle removing functions, such as phenols, flavonoids, polysaccharides, volatile oil, organic acids, triterpenoid saponins and the like. The invention also discloses a preparation method of the skin moisturizer, which is simple, convenient and is convenient to operate.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicine skin care, and particularly relates to a formula of a traditional Chinese medicine skin care lotion with whitening and freckle removing effects and a preparation method thereof.
Background
In recent years, with the increasing aesthetic consciousness of people, people seek fair skin, the products with poor quality stimulate people to seek higher quality for beauty care, and the use of skin-whitening and freckle-removing skin care products to achieve bright and white skin becomes a common pursuit of many beauty lovers. In recent years, beauty and skin care products have raised the trend of returning to nature, and green, nontoxic and effective substances in the nature are taken as raw materials, so that the beauty effect is ensured, and meanwhile, the requirements of consumers are met by the products which are milder and safer.
Various types of spots appear on the skin surface, and the main cause is the deposition of melanin. Melanin is a high molecular biological pigment mainly distributed in epidermal cells and keratinocytes of a human body, and the formation process of the melanin is a series of complex physiological and biochemical processes, so that in order to achieve the effects of whitening and removing freckles, the generation of the melanin is inhibited from the source, and the migration or decomposition of the generated melanin is cut off. The formation of melanin is closely related to tyrosinase, which is the main rate-limiting enzyme in the process of melanin formation, and when melanin is excessively accumulated, problems such as color spots, freckles, skin darkness and the like can be caused. The method reduces influence on melanin generation by inhibiting the activity of tyrosinase, and is the most main way for whitening and removing freckles; in addition, free radicals are one of the factors influencing melanogenesis, and research shows that the reduction of melanogenesis can be realized by removing free radicals; for the generated melanin, a mode of blocking the melanin from being transported from dendrites of melanocytes to keratinocytes can be adopted, and the expression of epidermal melanin is reduced, so that the whitening effect is achieved, and the better whitening and freckle removing effects are achieved.
Disclosure of Invention
The invention aims to provide the skin care lotion which is composed of traditional Chinese medicine extracts and has the effects of whitening and removing freckles, and can safely and effectively fade facial spots and make skin have good color.
The invention also aims to provide a preparation method of the skin care lotion with the effects of whitening and removing freckles, which is composed of the traditional Chinese medicine extracts, can retain the active ingredients in the extracting solution to the greatest extent, and is simple and convenient to operate.
In order to achieve the purpose, the technical scheme of the invention is as follows:
the traditional Chinese medicine skin care lotion with the effects of whitening and removing freckles is prepared from the following compound traditional Chinese medicine components in parts by mass: 5-25% of liquorice extract, 5-25% of jasmine flower extract, 5-25% of catechu extract, 5-25% of poria cocos extract, 4-15% of roughhaired holly root extract, 4-15% of angelica dahurica extract, 4-12% of kelp extract, 4-12% of broussonetia papyrifera extract, 4-12% of duckweed extract, 4-12% of oroxylum indicum extract, 4-12% of lygodium japonicum extract, 4-12% of radix pseudostellariae extract, 4-12% of lophatherum gracile extract, 2-8% of mulberry bark extract, 2-8% of peach blossom extract, 2-8% of aster tataricus extract, 2-8% of fresh aloe juice, 2-8% of 95% ethanol, 1-5% of propylene, 1-5% of glycerin, 1-5% of astaxanthin, 1-5% of ethoxylated lanolin (lanolin polyoxyethylene ether), 1-5% of tocopherol acetate and 0.05-0.3% of essence, wherein liquorice, jasminum grandiflorum, catechu, poria cocos, holly, kelp, angelica dahurica, broussonetia papyrifera, duckweed, oroxylum indicum, sargentgloryvine stem, radix pseudostellariae, lophatherum gracile and white mulberry root bark are the core formula of the compound traditional Chinese medicine skin care lotion, and other components are auxiliary formulas.
By adopting the technical scheme, the invention relates to a traditional Chinese medicine skin care lotion with whitening and freckle removing effects, which has the following beneficial effects: the liquorice in the formula contains 3 major active ingredients: flavones, triterpenes (glycyrrhizic acid as main ingredient) and polysaccharides, which have effects of preventing skin aging, effectively eliminating superoxide ion and inhibiting tyrosinase activity; the jasminum grandiflorum is rich in flavonoids, phenols, triterpenes and saccharides, and can improve immunity of the organism, prevent skin aging and inhibit melanin generation; catechin rich in Catechu can regulate oxygen free radical system, improve organism oxidation resistance and relieve pigmentation; the imperatorin contained in radix Angelicae Dahuricae can inhibit tyrosinase activity in melanocyte or block conduction of melanin synthesis signal, and can be used for preventing and treating mottle and chloasma; the radix pseudostellariae contains various saponins, amino acids, arbutin, vitamins and other effective components, and has remarkable curative effects on freckles, chloasma, butterfly spot and senile skin pigmentation; tuckahoe, poria cocos: the pachyman can improve and enhance cellular immunity and promote metabolism, the pachyman and pachylon triterpene can enhance superoxide dismutase activity and reduce peroxidase activity, and have antioxidant and antiaging effects, and hydroxyproline can increase collagen fiber in skin and delay skin aging. Most of the medicinal materials used in the main formula are selected from genuine producing areas, and the whitening active ingredients are rich, so that the effect is better compared with that in common producing areas.
Preferably, the preparation method of the traditional Chinese medicine skin care lotion with the effects of whitening and removing freckles comprises the following steps:
(1) respectively cleaning licorice, jasminum grandiflorum, catechu, poria cocos, roughhaired holly root, kelp, angelica dahurica, broussonetia papyrifera, duckweed, oroxylum indicum, lygodium japonicum, radix pseudostellariae, lophatherum gracile, cortex mori radicis, peach blossom, radix asteris and other medicinal materials, repeatedly extracting for 2-4 times with deionized water (95-100 ℃) in a ratio of 1: 12-14, 2-4 hours each time, filtering, and combining to obtain water extract of each traditional Chinese medicine;
(2) adding 95% ethanol (material-liquid ratio 1: 7-10) into the residue of each Chinese medicinal material, soaking at 40-70 deg.C for 24-48 hr, filtering, and mixing the ethanol filtrate with the water extractive solution of step (1);
(3) respectively adding the combined extracting solution into a macroporous resin adsorption column for adsorption elution, wherein an eluant is an ethanol solution with the mass/volume percentage of 20-30%, the elution flow rate is 2mL/min, and collecting the eluted extracting solution;
(4) adding the extract of each Chinese medicine after elution into a sterile tank according to the weight percentage of the formula in claim 2, and simultaneously adding propylene glycol, sodium hyaluronate, glycerol, astaxanthin, ethoxylated lanolin (lanolin polyoxyethylene ether), tocopherol acetate, fresh aloe juice and essence into the sterile tank according to the weight percentage of the formula in claim 2, and aging for 24-48 hours;
(5) filtering the aged traditional Chinese medicine skin care solution by adopting ultrafiltration membrane filtering equipment, wherein the adopted ultrafiltration membrane filtering equipment is Bestriver UF-BRT-380, the filtering mode is internal pressure type, the operating pressure is 0.3MPa, the working temperature is 35 ℃, the filtering precision is 6-50nm, macromolecular impurities invisible to naked eyes are thoroughly separated, and the traditional Chinese medicine skin care solution is bottled after being inspected to be qualified.
After the technical scheme is adopted, the method is simple and convenient to operate, the prepared traditional Chinese medicine skin care lotion is clear and bright, the feed liquid in the filtering process is operated in an internal pressure type mode, no filter aid is added, the filtering process is operated at pure physical normal temperature, no chemical reaction exists, thermosensitive components are not damaged, the purity of the traditional Chinese medicine is improved, the traditional Chinese medicine skin care lotion is easy to absorb by the skin, and the generation of melanin is inhibited and the discharge of melanin is promoted through multiple ways, so that the effects of whitening and removing freckles are achieved.
Detailed Description
First, in order to further explain the technical solution of the present invention, the present invention is explained in detail by the following specific examples.
Example 1:
in the embodiment, the important medicinal materials selected in the main medicine formula are genuine medicinal materials.
Preferably, the licorice origin is the western inner Mongolia; the production place of the jasminum grandiflorum is Yunnan; the producing place of the catechu is the south of Yunnan; the origin of the tuckahoe is the Dabie mountain area in the north of east Hubei province; the production place of the roughhaired holly is Guangdong Meizhou; the production place of the oroxylum indicum is Fujian; the radix Pseudostellariae is Cudrania tricuspidata No. 1 of Cudrania tricuspidata county, Ningde City of Fujian province.
(1) Respectively cleaning Glycyrrhrizae radix, flos Jasmini sambac, Catechu, Poria, flos Ilicis Asprellae, thallus laminariae, radix Angelicae Dahuricae, radix Broussonetiae, herba Spirodelae, semen Oroxyli, caulis Sargentodoxae, radix Pseudostellariae, folium Bambusae, cortex Mori, flos persicae, and radix Asteris, extracting with deionized water (98 deg.C) at a ratio of 1: 13 repeatedly for 3 times, each for 3 hr, filtering, and mixing to obtain water extractive solution of each Chinese medicine.
(2) Soaking the residue of each Chinese medicinal material in 95% ethanol (material-liquid ratio of 1: 8) at 55 deg.C for 36 hr, filtering, and mixing the ethanol filtrate with the water extractive solution.
(3) And (3) respectively adding the combined extracting solution into a macroporous resin (consisting of SP207 and HP2MGL in a mass ratio of 3: 7) adsorption column for adsorption elution, wherein an eluent is an ethanol solution with the mass/volume percentage of 25%, the elution flow rate is 2mL/min, and collecting the eluted extracting solution.
(4) Weighing 10% of eluted liquorice extract, 8% of jasminum grandiflorum extract, 8% of catechu extract, 8% of poria cocos extract, 7% of roughhaired holly extract, 6% of kelp extract, 6% of angelica dahurica extract, 6% of broussonetia papyrifera extract, 5% of duckweed extract, 4% of oroxylum indicum extract, 4% of lygodium japonicum extract, 4% of radix pseudostellariae extract, 4% of lophatherum gracile extract, 3% of mulberry bark extract, 3% of peach blossom extract and 2% of radix asteris extract, adding 1% of propylene glycol, 1.8% of sodium hyaluronate, 1.15% of glycerol, 1% of astaxanthin, 1% of ethoxylated lanolin (lanolin polyoxyethylene ether), 1% of tocopherol acetate, 5% of fresh aloe juice and 0.05% of essence into an aseptic tank.
(5) The aged traditional Chinese medicine skin care solution adopts Bestriver UF-BRT-380 ultrafiltration membrane filtration equipment, under the conditions that the operating pressure is 0.3MPa, the working temperature is 35 ℃ and the filtration precision is 6-50nm, an internal pressure type filtration mode is adopted to thoroughly separate macromolecular impurities invisible to the naked eye, and the aged traditional Chinese medicine skin care solution is bottled after being inspected to be qualified. Sterilizing, and labeling to obtain the final product.
Example 2:
in the embodiment, the important medicinal materials selected in the main medicine formula are genuine medicinal materials.
Preferably, the licorice origin is the western inner Mongolia; the production place of the jasminum grandiflorum is Yunnan; the producing place of the catechu is the south of Yunnan; the origin of the tuckahoe is the Dabie mountain area in the north of east Hubei province; the production place of the roughhaired holly is Guangdong Meizhou; the production place of the oroxylum indicum is Fujian; the radix Pseudostellariae is Cudrania tricuspidata No. 1 of Cudrania tricuspidata county, Ningde City of Fujian province.
(1) Respectively cleaning Glycyrrhrizae radix, flos Jasmini sambac, Catechu, Poria, flos Ilicis Asprellae, thallus laminariae, radix Angelicae Dahuricae, radix Broussonetiae, herba Spirodelae, semen Oroxyli, caulis Sargentodoxae, radix Pseudostellariae, folium Bambusae, cortex Mori, flos persicae, and radix Asteris, extracting with deionized water (98 deg.C) at a ratio of 1: 13 repeatedly for 3 times, each for 3 hr, filtering, and mixing to obtain water extractive solution of each Chinese medicine.
(2) Soaking the residue of each Chinese medicinal material in 95% ethanol (material-liquid ratio of 1: 8) at 55 deg.C for 36 hr, filtering, and mixing the ethanol filtrate with the water extractive solution. .
(3) And (3) respectively adding the combined extracting solution into a macroporous resin (consisting of SP207 and HP2MGL in a mass ratio of 3: 7) adsorption column for adsorption elution, wherein an eluent is an ethanol solution with the mass/volume percentage of 25%, the elution flow rate is 2mL/min, and collecting the eluted extracting solution.
(4) Weighing 8% of eluted liquorice extract, 7% of jasminum grandiflorum extract, 7% of catechu extract, 6% of poria cocos extract, 6% of roughhaired holly extract, 7% of kelp extract, 7% of angelica dahurica extract, 4% of broussonetia papyrifera extract, 6% of duckweed extract, 5% of oroxylum indicum extract, 5% of lygodium japonicum extract, 5% of radix pseudostellariae extract, 4% of lophatherum gracile extract, 4% of cortex mori extract, 4% of peach blossom extract and 3% of radix asteris extract according to weight percentage, adding the raw materials into an aseptic tank, and simultaneously adding 1% of propylene glycol, 1.8% of sodium hyaluronate, 1.15% of glycerol, 1% of astaxanthin, 1% of ethoxylated lanolin (lanolin polyoxyethylene ether), 1% of tocopherol acetate, 5% of fresh.
(5) The aged traditional Chinese medicine skin care solution adopts Bestriver UF-BRT-380 ultrafiltration membrane filtration equipment, under the conditions that the operating pressure is 0.3MPa, the working temperature is 35 ℃ and the filtration precision is 6-50nm, an internal pressure type filtration mode is adopted to thoroughly separate macromolecular impurities invisible to the naked eye, and the aged traditional Chinese medicine skin care solution is bottled after being inspected to be qualified. Sterilizing, and labeling to obtain the final product.
Example 3:
in the embodiment, the important medicinal materials selected in the main medicine formula are genuine medicinal materials.
Preferably, the licorice origin is the western inner Mongolia; the production place of the jasminum grandiflorum is Yunnan; the producing place of the catechu is the south of Yunnan; the origin of the tuckahoe is the Dabie mountain area in the north of east Hubei province; the production place of the roughhaired holly is Guangdong Meizhou; the production place of the oroxylum indicum is Fujian; the radix Pseudostellariae is Cudrania tricuspidata No. 1 of Cudrania tricuspidata county, Ningde City of Fujian province.
(1) Respectively cleaning Glycyrrhrizae radix, flos Jasmini sambac, Catechu, Poria, flos Ilicis Asprellae, thallus laminariae, radix Angelicae Dahuricae, radix Broussonetiae, herba Spirodelae, semen Oroxyli, caulis Sargentodoxae, radix Pseudostellariae, folium Bambusae, cortex Mori, flos persicae, and radix Asteris, extracting with deionized water (98 deg.C) at a ratio of 1: 13 repeatedly for 3 times, each for 3 hr, filtering, and mixing to obtain water extractive solution of each Chinese medicine.
(2) Soaking the residue of each Chinese medicinal material in 95% ethanol (material-liquid ratio of 1: 8) at 55 deg.C for 36 hr, filtering, and mixing the ethanol filtrate with the water extractive solution.
(3) And (3) respectively adding the combined extracting solution into a macroporous resin (consisting of SP207 and HP2MGL in a mass ratio of 3: 7) adsorption column for adsorption elution, wherein an eluent is an ethanol solution with the mass/volume percentage of 25%, the elution flow rate is 2mL/min, and collecting the eluted extracting solution.
(4) Weighing 5% of eluted liquorice extract, 5% of jasminum grandiflorum extract, 5% of catechu extract, 5% of poria cocos extract, 7% of roughhaired holly extract, 7% of kelp extract, 8% of angelica dahurica extract, 6% of broussonetia papyrifera extract, 6% of duckweed extract, 6% of oroxylum indicum extract, 4% of lygodium japonicum extract, 4% of radix pseudostellariae extract, 4% of lophatherum gracile extract, 6% of cortex mori extract, 5% of peach blossom extract and 5% of radix asteris extract according to weight percentage, adding the raw materials into an aseptic tank, and simultaneously adding 1% of propylene glycol, 1.8% of sodium hyaluronate, 1.15% of glycerol, 1% of astaxanthin, 1% of ethoxylated lanolin (lanolin polyoxyethylene ether), 1% of tocopherol acetate, 5% of fresh.
(5) The aged traditional Chinese medicine skin care solution adopts Bestriver UF-BRT-380 ultrafiltration membrane filtration equipment, under the conditions that the operating pressure is 0.3MPa, the working temperature is 35 ℃ and the filtration precision is 6-50nm, an internal pressure type filtration mode is adopted to thoroughly separate macromolecular impurities invisible to the naked eye, and the aged traditional Chinese medicine skin care solution is bottled after being inspected to be qualified. Sterilizing, and labeling to obtain the final product.
Example 4:
in this example, all herbs were selected from the general production area.
(1) Respectively cleaning Glycyrrhrizae radix, flos Jasmini sambac, Catechu, Poria, flos Ilicis Asprellae, thallus laminariae, radix Angelicae Dahuricae, radix Broussonetiae, herba Spirodelae, semen Oroxyli, caulis Sargentodoxae, radix Pseudostellariae, folium Bambusae, cortex Mori, flos persicae, and radix Asteris, extracting with deionized water (98 deg.C) at a ratio of 1: 13 repeatedly for 3 times, each for 3 hr, filtering, and mixing to obtain water extractive solution of each Chinese medicine.
(2) Soaking the residue of each Chinese medicinal material in 95% ethanol (material-liquid ratio of 1: 8) at 55 deg.C for 36 hr, filtering, and mixing the ethanol filtrate with the water extractive solution.
(3) And (3) respectively adding the combined extracting solution into a macroporous resin (consisting of SP207 and HP2MGL in a mass ratio of 3: 7) adsorption column for adsorption elution, wherein an eluent is an ethanol solution with the mass/volume percentage of 25%, the elution flow rate is 2mL/min, and collecting the eluted extracting solution.
(4) Weighing 10% of eluted liquorice extract, 8% of jasminum grandiflorum extract, 8% of catechu extract, 8% of poria cocos extract, 7% of roughhaired holly extract, 6% of kelp extract, 6% of angelica dahurica extract, 6% of broussonetia papyrifera extract, 5% of duckweed extract, 4% of oroxylum indicum extract, 4% of lygodium japonicum extract, 4% of radix pseudostellariae extract, 4% of lophatherum gracile extract, 3% of mulberry bark extract, 3% of peach blossom extract and 2% of radix asteris extract, adding 1% of propylene glycol, 1.8% of sodium hyaluronate, 1.15% of glycerol, 1% of astaxanthin, 1% of ethoxylated lanolin (lanolin polyoxyethylene ether), 1% of tocopherol acetate, 5% of fresh aloe juice and 0.05% of essence into an aseptic tank.
(5) The aged traditional Chinese medicine skin care solution adopts Bestriver UF-BRT-380 ultrafiltration membrane filtration equipment, under the conditions that the operating pressure is 0.3MPa, the working temperature is 35 ℃ and the filtration precision is 6-50nm, an internal pressure type filtration mode is adopted to thoroughly separate macromolecular impurities invisible to the naked eye, and the aged traditional Chinese medicine skin care solution is bottled after being inspected to be qualified. Sterilizing, and labeling to obtain the final product.
And secondly, irritation and allergy tests of the traditional Chinese medicine skin care lotion.
(1) Experimental animals: 50 Kunming white mice were randomly divided into 5 groups, a blank group and 10 groups of examples 1, 2, 3 and 4, and the back hair of the mice was shaved with a shaver.
(2) The experimental process comprises the following steps: the back of the blank group of mice was smeared with physiological saline, and the mice of the example group were smeared with the prepared skin moisturizers, and continuously observed for one week.
(3) The experimental results are as follows: by comparing the blank group mice with the test group mice, no irritation or anaphylactic reaction is found, which indicates that the skin lotion has no irritation or anaphylaxis.
And thirdly, the samples prepared in the examples measure the tyrosinase inhibition rate and the DPPH free radical clearance rate.
(I) determination of tyrosinase inhibition:
1. preparing a solution:
(1) preparation of Phosphate Buffered Saline (PBS): respectively and accurately weighing 71.6g of disodium hydrogen phosphate and 31.2g of sodium dihydrogen phosphate, adding deionized water to fully dissolve, respectively transferring to a 1000mL measuring flask to constant volume to prepare 0.2 mol.L～1The solution of (4) is mixed uniformly according to the proportion of 51: 49, and the pH is adjusted to 6.8, thus obtaining the product.
(2) Preparation of tyrosinase solution: accurately weighing a certain amount of 920 U.mg～1Tyrosinase, dissolved in PBS to 200 U.mg～1The enzyme solution is preserved and frozen in a refrigerator at the subzero temperature environment.
(3) Preparing a dopa solution: precisely weighing a certain amount of L-dopamine, and adding a small amount of 0.1 mol.L-1Pre-dissolving in hydrochloric acid solution, diluting with PBS to 1.5 g.L～1Dopa solution, stored at 4 ℃ in the dark.
(4) And diluting the skin care lotion obtained in the examples 1-4 by 2 times by using PBS to obtain a sample to be detected.
2. Measurement method
Respectively adding PBS, a sample to be detected and a tyrosinase solution into each test tube according to the design of table 1, uniformly mixing, reacting in a constant-temperature water bath (37 ℃) for 10min, respectively and rapidly transferring into 1mL of dopa solution, uniformly mixing, placing in a water bath for reacting for 5min, and immediately detecting A when the reaction reaches 5minλWhen the test piece is 475, A is measured1、A2、A3And A4The test was performed in parallel 3 times. Calculating according to the formula:
TABLE 1 composition of the reaction solution
(II) determination of DPPH radical scavenging Rate:
1. preparing a solution:
(1) accurately weighing a certain amount of DPPH, adding absolute ethyl alcohol to dissolve the DPPH to prepare the product with the mass concentration of about 0.04 g.L～1The DPPH solution is stored at 4 ℃ in the dark for later use.
(2) The skin lotions obtained in examples 1 to 4 were diluted 100 times with ethanol (95%) to obtain samples to be tested.
2. The determination method comprises the following steps:
precisely transferring the DPPH free radical solution and absolute ethyl alcohol into the same test tube with 2mL each, uniformly mixing, reacting for 20min in a dark place, and measuring the absorbance A of lambda-5171. Precisely transferring 2mL of each of the DPPH free radical solution and the sample solution to be detected into the same test tube, uniformly mixing, reacting for 20min in a dark place, and measuring the absorbance A of lambda (517)2(ii) a Precisely transferring 2mL of ethanol and sample solution to be detected into the same test tube, mixing, standing in dark for 20min, and measuring lambda-517 absorbance A3.3 replicates were performed. The DPPH clearance rate of the test liquid medicine is calculated according to a formula:
(III) results:
as can be seen from table 2, the skin care lotion with whitening and spot removing effects prepared in example 1 has the highest tyrosinase inhibition rate, while the DPPH clearance rate in example 2 is slightly higher than that in examples 1, 3 and 4, and the whitening effect in example 1 is the best in comprehensive consideration. Wherein the tyrosinase inhibition rate and DPPH clearance rate of example 1 using genuine herbs are higher than those of example 4 using genuine herbs, compared with example 1 where the Chinese herbal medicine components have the same specific gravity.
Table 2 results of skin lotions according to different examples
Note: the overall score is tyrosinase inhibition x 50% + DPPH clearance x 50%.
Claims (4)
1. The traditional Chinese medicine skin care lotion with the effects of whitening and removing freckles is characterized by comprising the following components: licorice, jasminum grandiflorum, catechu, poria cocos, roughhaired holly, kelp, angelica dahurica, broussonetia papyrifera, duckweed, oroxylum indicum, lygodium japonicum, radix pseudostellariae, lophatherum gracile, cortex mori, peach blossom, aster, aloe, 95% ethanol, propylene glycol, sodium hyaluronate, glycerol, astaxanthin, ethoxylated lanolin (lanolin polyoxyethylene ether), tocopherol acetate and essence.
2. The traditional Chinese medicine skin care lotion with whitening and freckle removing effects according to claim 1 is characterized in that:
the core components and the weight percentage are as follows: 5-25% of liquorice extract, 5-25% of jasmine flower extract, 5-25% of catechu extract, 5-25% of poria cocos extract, 4-15% of roughhaired holly extract, 4-15% of angelica dahurica extract, 4-12% of kelp extract, 4-12% of broussonetia papyrifera extract, 4-12% of duckweed extract, 4-12% of oroxylum indicum extract, 4-12% of lygodium japonicum extract, 4-12% of radix pseudostellariae extract, 4-12% of lophatherum gracile extract and 2-8% of cortex mori extract.
The auxiliary components and the weight percentage are as follows: 2 to 8 percent of peach blossom extracting solution, 2 to 8 percent of aster extracting solution, 2 to 8 percent of fresh aloe juice, 2 to 8 percent of 95 percent ethanol, 1 to 5 percent of propylene glycol, 1 to 5 percent of sodium hyaluronate, 1 to 5 percent of glycerol, 1 to 5 percent of astaxanthin, 1 to 5 percent of ethoxylated lanolin (lanolin polyoxyethylene ether), 1 to 5 percent of tocopherol acetate and 0.05 to 0.3 percent of essence.
3. A preparation method of a traditional Chinese medicine skin care lotion with whitening and freckle removing effects is characterized by comprising the following steps: the preparation method comprises the following specific steps:
(1) respectively cleaning licorice, jasminum grandiflorum, catechu, poria cocos, roughhaired holly root, kelp, angelica dahurica, broussonetia papyrifera, duckweed, oroxylum indicum, lygodium japonicum, radix pseudostellariae, lophatherum gracile, cortex mori radicis, peach blossom, radix asteris and other medicinal materials, repeatedly extracting for 2-4 times with deionized water (95-100 ℃) in a ratio of 1: 12-14, 2-4 hours each time, filtering, and combining to obtain water extract of each traditional Chinese medicine;
(2) adding 95% ethanol (material-liquid ratio 1: 7-10) into the residue of each Chinese medicinal material, soaking at 40-70 deg.C for 24-48 hr, filtering, and mixing the ethanol filtrate with the water extractive solution of step (1);
(3) respectively adding the combined extracting solution into a macroporous resin adsorption column for adsorption elution, wherein an eluant is an ethanol solution with the mass/volume percentage of 20-30%, the elution flow rate is 2mL/min, and collecting the eluted extracting solution;
(4) adding the extract of each Chinese medicine after elution into a sterile tank according to the weight percentage of the formula in claim 2, and simultaneously adding propylene glycol, sodium hyaluronate, glycerol, astaxanthin, ethoxylated lanolin (lanolin polyoxyethylene ether), tocopherol acetate, fresh aloe juice and essence into the sterile tank according to the weight percentage of the formula in claim 2, and aging for 24-48 hours;
(5) filtering the aged traditional Chinese medicine skin care solution by adopting ultrafiltration membrane filtering equipment, wherein the adopted ultrafiltration membrane filtering equipment is Bestriver UF-BRT-380, the filtering mode is internal pressure type, the operating pressure is 0.3MPa, the working temperature is 35 ℃, the filtering precision is 6-50nm, macromolecular impurities invisible to naked eyes are thoroughly separated, and the traditional Chinese medicine skin care solution is bottled after being inspected to be qualified.
4. The preparation method of the traditional Chinese medicine skin care lotion with whitening and freckle removing effects according to claim 3, which is characterized by comprising the following steps of: the macroporous resin of the macroporous resin adsorption column used in the preparation process is formed by mixing two types of resins, namely SP207 and HP2MGL, and the mass ratio is as follows: SP 207: HP2MGL is 3: 7.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010527680.8A CN111603429A (en) | 2020-06-06 | 2020-06-06 | Traditional Chinese medicine skin care lotion with whitening and freckle removing effects and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010527680.8A CN111603429A (en) | 2020-06-06 | 2020-06-06 | Traditional Chinese medicine skin care lotion with whitening and freckle removing effects and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111603429A true CN111603429A (en) | 2020-09-01 |
Family
ID=72195060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010527680.8A Pending CN111603429A (en) | 2020-06-06 | 2020-06-06 | Traditional Chinese medicine skin care lotion with whitening and freckle removing effects and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111603429A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120899556A (en) * | 2025-10-13 | 2025-11-07 | 广东艾粒生物科技有限责任公司 | A resveratrol composition with whitening and spot-fading effects, its preparation method and application |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895291A (en) * | 2006-06-09 | 2007-01-17 | 陈永丽 | Nano-Chinese medicinal biological product and its preparation |
| CN101287441A (en) * | 2005-07-25 | 2008-10-15 | 巴斯夫欧洲公司 | Dermocosmetic preparations |
| CN102028752A (en) * | 2010-12-29 | 2011-04-27 | 北京同仁堂麦尔海生物技术有限公司 | Chinese herbal medicine compound freckle-removing and skin-whitening composition and external preparation |
| CN102406592A (en) * | 2011-11-28 | 2012-04-11 | 广东轻工职业技术学院 | Chinese medicine extract composition with whitening skin care function and application of Chinese medicine extract composition |
| CN105748390A (en) * | 2016-03-10 | 2016-07-13 | 徐杰 | Whitening and moisturizing mask and preparation method thereof |
| CN109512775A (en) * | 2019-01-16 | 2019-03-26 | 徐为公 | A kind of anti crease and anti senile old MASQUE APAISANT HYDRATANT of whitening anti-acne |
| CN109820739A (en) * | 2018-11-27 | 2019-05-31 | 广州瑞誉化工科技有限公司 | A kind of skin composition and its preparation method and application of Plantain skin lightening |
-
2020
- 2020-06-06 CN CN202010527680.8A patent/CN111603429A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101287441A (en) * | 2005-07-25 | 2008-10-15 | 巴斯夫欧洲公司 | Dermocosmetic preparations |
| CN1895291A (en) * | 2006-06-09 | 2007-01-17 | 陈永丽 | Nano-Chinese medicinal biological product and its preparation |
| CN102028752A (en) * | 2010-12-29 | 2011-04-27 | 北京同仁堂麦尔海生物技术有限公司 | Chinese herbal medicine compound freckle-removing and skin-whitening composition and external preparation |
| CN102406592A (en) * | 2011-11-28 | 2012-04-11 | 广东轻工职业技术学院 | Chinese medicine extract composition with whitening skin care function and application of Chinese medicine extract composition |
| CN105748390A (en) * | 2016-03-10 | 2016-07-13 | 徐杰 | Whitening and moisturizing mask and preparation method thereof |
| CN109820739A (en) * | 2018-11-27 | 2019-05-31 | 广州瑞誉化工科技有限公司 | A kind of skin composition and its preparation method and application of Plantain skin lightening |
| CN109512775A (en) * | 2019-01-16 | 2019-03-26 | 徐为公 | A kind of anti crease and anti senile old MASQUE APAISANT HYDRATANT of whitening anti-acne |
Non-Patent Citations (1)
| Title |
|---|
| 刘旭峰: "《生活中的化学》", 31 August 2019, 北京：中国纺织出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120899556A (en) * | 2025-10-13 | 2025-11-07 | 广东艾粒生物科技有限责任公司 | A resveratrol composition with whitening and spot-fading effects, its preparation method and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102247446B (en) | Composite whitening and spot correcting lotion and manufacturing method thereof | |
| US7189419B2 (en) | Use of active extracts to lighten skin, lips, hair, and/or nails | |
| KR20080073466A (en) | Composition made using herbal mixture and method for preparing same | |
| CN105147991A (en) | Traditional Chinese medicine combination for inhibiting melanin generation and preparation method and application thereof | |
| KR20140126892A (en) | External composition for skin containing Ginsenoside Rg3 | |
| Pang et al. | Molecular understanding of the therapeutic potential of melanin inhibiting natural products | |
| CN104523479B (en) | Application and whitening articles for use of the himalayan prinsepia leaf extract in whitening articles for use | |
| CN113288836A (en) | Preparation method and application of acne-removing compound | |
| KR20130090029A (en) | Manufacturing method of skin external and skin external composition mainly with steamed ginseng seeds using the same | |
| CN112675101A (en) | Whitening and freckle-removing composition, whitening and freckle-removing cream and preparation method thereof | |
| CN115569103B (en) | Plant whitening and freckle removing composition and preparation method and application thereof | |
| CN111603429A (en) | Traditional Chinese medicine skin care lotion with whitening and freckle removing effects and preparation method thereof | |
| JPS61115013A (en) | Cosmetic | |
| KR101700105B1 (en) | A composition for antioxidating, whitening and improving wrinkle comprising extracts of false indigo | |
| US11672753B2 (en) | Composition for sebum control and pore minimizing | |
| KR101725969B1 (en) | A cosmetic composition effective for skin whitening comprising multiple herbal extracts | |
| JP2011088854A (en) | Involucrin expression inhibitor | |
| KR101515443B1 (en) | The functional cosmetic composition for anti-wrinkle, skin whitening and recovery of distrupted skin containing, comprising the mixture of extract of bergamot, Lonicera japonica Thunberg, Coix lachryma-jobi var. mayuen and wheat bud | |
| KR100750352B1 (en) | Cosmetic composition for whitening skin containing herbal extracts and method for producing the same | |
| KR20010028372A (en) | Cosmetic material composition for skin whitening | |
| CN113425635A (en) | Elsholtzia extract, its preparation and use | |
| CN109125150A (en) | A kind of skin care item and the preparation method and application thereof containing hawthorne leaf P.E | |
| CN113133959A (en) | Wild buckwheat rhizome extract, preparation method and application thereof | |
| KR20080111299A (en) | External preparation composition for skin whitening containing camphorol-3,7-O-alpha-L-diramnopyranoside | |
| KR20220099259A (en) | Skin whitening composition comprising Safflower seed oil hydrolyzate and Saururus chinensis extract |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20200901 |
|
| WD01 | Invention patent application deemed withdrawn after publication |