CN111603395B - Whitening and moisturizing emulsion containing lamellar liquid crystal and preparation method thereof - Google Patents

Abstract

The invention relates to a whitening and moisturizing lotion containing lamellar liquid crystal and a preparation method thereof. The invention mixes an oil phase, an emulsifier, a higher alcohol, beeswax, dimethylsiloxane, vitamin E and vitamin C, heats and stirs, Obtaining an oil phase; adding glycerin, propylene glycol, panthenol, sodium hyaluronate, nicotinamide, and p-hydroxyacetophenone to the purified water, heating and stirring to obtain an aqueous phase; adding xanthan gum and disodium EDTA to the purified water, Stir to obtain a water-soluble polymer solution; the above three phases are mixed together, emulsified at a certain homogenization speed, and the emulsification is completed, stirring and degassing, cooling, adding chamomile extract during the cooling process, and stirring to obtain a uniform and stable lotion. The emulsion obtained by the invention has good stability, uniform particle size, and contains a large number of lamellar liquid crystal phases. The existence of the lamellar liquid crystal phases improves product stability and moisturizing effect, and the product has moisturizing, whitening and anti-oxidation functions.

Description

A kind of whitening and moisturizing lotion containing lamellar liquid crystal and preparation method thereof

technical field

The invention relates to a whitening and moisturizing lotion containing lamellar liquid crystal and a preparation method thereof, belonging to the technical field of skin care products.

Background technique

With the improvement of people's living standards, people's demand and requirements for cosmetics are also getting higher and higher, especially with the change of living environment, higher requirements are put forward for whitening and moisturizing products. Melanin is a protein that exists in the basal layer of everyone's skin and is the main culprit that affects skin whitening. The exposure of ultraviolet rays will change the melanin to produce a substance that protects the skin, and then the melanin will move through the layers of cell metabolism to the epidermis of the skin, causing skin problems such as pigmentation and uneven skin tone.

Skin cells and tissues are prone to loss of water. Once the skin’s water content is insufficient, it may cause obstacles to the delivery of nutrients to the skin. At the same time, the signal transduction between skin cells and organelles will malfunction, resulting in faulty or interrupted signal transduction. The accumulation and increase of these subtle changes in the skin will disrupt the normal structure and function of the skin. The short-term consequences are that the skin becomes dry, unhydrated, and tight; the long-term consequences are skin aging, wrinkles, And become rough, dull, and inflexible. Moisturizing is an essential part of daily skin care. Professional hydrating and moisturizing cosmetics, which can deeply and effectively replenish moisture, nourish and moisturize the skin.

Niacinamide, a derivative of vitamin _B3 , is also a skin anti-aging ingredient for workers in the field of cosmetic dermatology. Its most important effect in skin anti-aging is to reduce and prevent the dull complexion and hairiness of the skin during the early aging process. Yellow, vegetable. At the same time, niacinamide can repair the damaged stratum corneum lipid barrier and improve skin resistance. Not only that, but niacinamide also has a deep water-locking effect.

Layered liquid crystal refers to that it can stably exist on the oil-water interface of the oil-in-water emulsion under certain conditions. It is an aggregation state between solid and liquid. Its molecular arrangement is long-range ordered, and it has liquid-like fluidity. and continuity, and anisotropy similar to crystals. With the development of new types of cosmetics, cosmetics containing lamellar liquid crystals have been classified as high-tech cosmetics. Cosmetics containing a lamellar liquid crystal structure have good stability; at the same time, it can prolong hydration and closure, so it has excellent moisturizing properties. Compared with ordinary cosmetics, lamellar liquid crystal cosmetics have four characteristics: improving product stability, efficient moisturizing, slow release of active ingredients and providing excellent skin feel.

At present, there are also a few reports on moisturizing emulsions with lamellar liquid crystals, but the emulsifiers used in the existing moisturizing emulsions with lamellar liquid crystals are liquid crystal emulsifiers, such as lecithins, sucrose esters, phytosterols , glucosides, these are currently commonly used liquid crystal emulsifiers. Long-term research has found that these liquid crystal emulsifiers have high cost, and second, the number of liquid crystals formed is small, and the size of droplets is uneven. For example, Chinese patent document CN109363954A discloses a moisturizing emulsion with lamellar liquid crystal, which, in parts by weight, includes the following components: 1.5-3.5 parts of natural liquid crystal emulsifier; 1-3 parts of solid grease; 4-8 parts of liquid grease 1-10 parts of moisturizing agent; 60-80 parts of water, the natural liquid crystal emulsifier is selected from one or more of lecithins, sucrose esters, phytosterols, and glucosides; preferably, The natural liquid crystal emulsifier is selected from one or more of hydrogenated lecithin, sucrose stearate, sucrose distearate, and phytosterols.

SUMMARY OF THE INVENTION

Aiming at the deficiencies of the prior art, especially the difficulties of the high cost of the emulsifier used in the current moisturizing lotion, the small number of liquid crystals formed, and the uneven size of the droplets, the present invention provides a whitening moisturizing lotion containing lamellar liquid crystals and a preparation method thereof .

The invention adopts a low-cost emulsifier and a specific co-emulsifier for compounding, and forms a layered liquid crystal at the oil-water interface through interaction, which can well encapsulate the active ingredients, has good whitening and moisturizing effects, and reduces costs at the same time. Get excellent moisturizing power.

The technical scheme of the present invention is as follows:

A whitening and moisturizing lotion containing lamellar liquid crystal, comprising the following raw materials by weight:

2-25 parts of oil phase, 5-12 parts of emulsifier, 3-10 parts of higher alcohol, 0.5-3 parts of beeswax, 0.2-2 parts of 1,3-butanediol, 1-5 parts of dimethylsiloxane , 5-15 parts of glycerin, 0.5-3 parts of panthenol, 0.5-3 parts of propylene glycol, 0.2-1 part of xanthan gum, 0.3-2 parts of chamomile extract, 0.01-0.5 part of vitamin E, 0.01-0.5 part of vitamin C parts, 0.1-5.0 parts of whitening and moisturizing ingredients, 0.05-0.2 parts of p-hydroxyacetophenone, 0.05-0.3 parts of disodium EDTA, and 30-90 parts of purified water.

According to a preferred aspect of the present invention, a whitening and moisturizing lotion containing lamellar liquid crystals includes the following raw materials by weight:

5-20 parts of oil phase, 5-10 parts of emulsifier, 5-10 parts of higher alcohol, 0.5-3 parts of beeswax, 0.5-1.5 parts of 1,3-butanediol, 1-4 parts of dimethylsiloxane , 7-12 parts of glycerin, 1-2 parts of panthenol, 1-2.5 parts of propylene glycol, 0.5-1 part of xanthan gum, 0.5-1 part of chamomile extract, 0.05-0.2 part of vitamin E, 0.05-0.2 part of vitamin C parts, 0.5-3.0 parts of whitening and moisturizing ingredients, 0.05-0.1 parts of p-hydroxyacetophenone, 0.1-0.25 parts of disodium EDTA, and 35-80 parts of purified water.

Preferably according to the present invention, the emulsifier is any mixture of one or more of PEG-40 hydrogenated castor oil, glycerol monostearate, polysorbate-40 or cetearyl glucoside .

Most preferably, the emulsifier is glycerol monostearate.

Preferably according to the present invention, the higher alcohol is an aliphatic alcohol with more than 12 carbon atoms in the carbon chain.

Further preferably, the high-carbon alcohol is one or more of cetearyl alcohol, sorbitol or lauryl alcohol, mixed arbitrarily.

Most preferably, the higher alcohol is cetearyl alcohol.

Preferably according to the present invention, the oil phase is any mixture of one or more of olive oil, caprylic/capric triglyceride, castor oil, squalane or jojoba oil.

Further preferably, the oil phase is a mixture of caprylic/capric triglyceride and hydrogenated castor oil.

Preferably according to the present invention, the whitening and moisturizing factor is selected from one or more of sodium hyaluronate, ceramide, nicotinamide, polyethylene glycol or phenethyl resorcinol, which is arbitrarily mixed.

Further preferably, the whitening and moisturizing factor is a mixture of sodium hyaluronate and niacinamide.

A whitening and moisturizing lotion with lamellar liquid crystal, comprising the following raw materials by weight:

Caprylic/Capric Triglyceride 4-15 Parts, Castor Oil 1-5 Parts, Glycerol Monostearate 5-10 Parts, Cetearyl Alcohol 5-10 Parts, Beeswax 0.5-3 Parts, 1,3- Butylene Glycol 0.5-1.5 Parts, Dimethicone 1-4 Parts, Glycerin 7-12 Parts, Panthenol 1-2 Parts, Propylene Glycol 1-2.5 Parts, Xanthan Gum 0.5-1 Parts, Chamomile Extract 0.5 Parts ~1 part, vitamin E 0.05-0.2 part, vitamin C 0.05-0.2 part, sodium hyaluronate 0.2-1 part, niacinamide 0.3-1.5 part, p-hydroxyacetophenone 0.05-0.1 part, disodium EDTA 0.1-0.25 35-80 parts of purified water.

A scheme with better effect of the present invention:

A whitening and moisturizing lotion containing lamellar liquid crystal, comprising the following raw materials by weight:

Caprylic/Capric Triglyceride 5 Parts, Castor Oil 2 Parts, Glycerol Monostearate 5 Parts, Cetearyl Alcohol 4 Parts, Beeswax 1 Part, 1,3-Butanediol 0.5 Parts, Dimethicone 1 part of oxane, 10 parts of glycerin, 1 part of panthenol, 1 part of propylene glycol, 0.7 part of xanthan gum, 0.5 part of chamomile extract, 0.2 part of vitamin E, 0.2 part of vitamin C, 0.3 part of sodium hyaluronate, 0.5 part of niacinamide parts, 0.1 part of p-hydroxyacetophenone, 0.1 part of disodium EDTA, 66.9 parts of purified water.

Another scheme with better effect of the present invention:

A whitening and moisturizing lotion containing lamellar liquid crystal, comprising the following raw materials by weight:

Caprylic/Capric Triglyceride 5 Parts, Castor Oil 2 Parts, Glycerol Monostearate 5 Parts, Cetearyl Alcohol 3 Parts, Beeswax 1.5 Parts, 1,3-Butanediol 0.5 Parts, Dimethicone 1 part of oxane, 12 parts of glycerin, 1 part of panthenol, 1 part of propylene glycol, 0.5 part of xanthan gum, 0.5 part of chamomile extract, 0.2 part of vitamin E, 0.2 part of vitamin C, 0.3 part of sodium hyaluronate, 0.5 part of niacinamide parts, 0.1 part of p-hydroxyacetophenone, 0.1 part of disodium EDTA, 65.6 parts of purified water.

One of the keys of the present invention is to use common, low-cost emulsifiers and high-carbon alcohols for compounding. The whitening and moisturizing lotion containing lamellar liquid crystal was obtained, and the ratio of emulsifier and higher alcohol was too large or too small to obtain lamellar liquid crystal, both of which were in the form of emulsion, and the selection of emulsifier was also the same. The low-cost emulsifier is compounded with high-carbon alcohol, and other materials are combined to finally obtain a whitening and moisturizing lotion containing lamellar liquid crystal, with a large number of liquid crystals, uniform droplet size, low cost, and whitening effect.

The second object of the present invention is to provide a method for preparing a whitening and moisturizing lotion containing lamellar liquid crystals.

A preparation method of a whitening and moisturizing lotion containing lamellar liquid crystal, comprising the following steps:

(1) Preparation of oil phase: Mix oil phase, emulsifier, higher alcohol, beeswax, dimethylsiloxane, vitamin E and vitamin C, heat to 50-70°C, stir for 2-10min, and obtain uniform mixing the oil phase;

(2) Preparation of water phase: add glycerin, propylene glycol, panthenol, sodium hyaluronate, nicotinamide, and p-hydroxyacetophenone into purified water, heat to 50-70°C, and stir for 2-10min to obtain a uniformly mixed water box;

(3) preparation of water-soluble polymer solution: adding xanthan gum and disodium EDTA to purified water, stirring, to obtain a well-mixed water-soluble polymer solution;

(4) heating and mixing the oil phase, the water phase and the water-soluble polymer solution to homogenize;

(5) Slowly stirring the homogenized mixture, degassing and cooling, adding chamomile extract, and stirring for 1-2 hours to obtain a uniform and stable emulsion.

Preferably according to the present invention, in step (4), the temperature of heating and mixing is 40-80° C.; the homogeneous stirring speed is 5,000-20,000 r\min.

Preferably according to the present invention, in step (5), the slow stirring speed is 200-400r\min.

The whitening and moisturizing lotion of the present invention can also add essence according to individual needs, and the essence is added together with the chamomile extract in step (5).

Technical characteristics and beneficial effects of the present invention:

1. Laminar liquid crystal is a type of liquid crystal, with the structure of oil/liquid crystal/water, while the structure of the human stratum corneum skin is oil/stratum corneum/water, and the structures of the two are very similar. The present invention introduces the layered liquid crystal into the emulsion system, and the existence of the layered liquid crystal improves the stability of the emulsion, so that the emulsion has efficient moisturizing effect, slow release effect of active ingredients, and excellent skin feel. The liquid crystal phase can be adsorbed on the oil-water interface, thereby forming a stable protective layer, which can well reduce the droplet aggregation caused by the collision between droplets; at the same time, due to the high viscosity of the liquid crystal phase, it is extremely Greatly improves the stability of the emulsion. The lamellar liquid crystal is a multi-layered structure composed of a surfactant and water, so a large amount of water exists in the lamellar liquid crystal. Therefore, when the emulsion with lamellar liquid crystals is applied to human skin, the water will not volatilize quickly and can be retained for a longer time, which makes the emulsion have efficient moisturizing properties. For encapsulated active ingredients, especially oil-soluble active ingredients, they can only be released when the oil-water interface is destroyed. Compared with the oil-water interface of common surfactants, lamellar liquid crystals have better stability and are less likely to be damaged, resulting in slower release of active ingredients.

2, the present invention adopts common, low-cost emulsifier and high-carbon alcohol compound, the emulsifier selected in the present invention is close to the long carbon chain structure of high-carbon alcohol, plus a specific ratio, and finally obtains the containing layer. The whitening and moisturizing lotion of liquid crystal, the ratio of emulsifier and higher alcohol is too large or too small to obtain lamellar liquid crystal, both are in the form of emulsion, the selection of emulsifier is also the same, the present invention adopts common, low cost The emulsifier is compounded with high-carbon alcohol, and other materials are combined to finally obtain a whitening and moisturizing lotion containing lamellar liquid crystals, a large number of liquid crystals, uniform droplet size, low cost, and whitening effect.

3. The niacinamide used in the present invention is a derivative of vitamin B3, and is also a skin anti-aging ingredient for workers in the field of cosmetic dermatology. The complexion is dull, yellow, and pale. At the same time, niacinamide can repair the damaged stratum corneum lipid barrier and improve skin resistance. The preferred sodium hyaluronate is a good humectant with significant hygroscopicity at low relative humidity and the opposite at high relative humidity, a property that makes it suitable for many seasons; in addition, hyaluronic acid Sodium also has the functions of nourishing the skin, preventing and repairing skin damage. The preferably used xanthan gum is a water-soluble macromolecule, which can impart good stability to the emulsion and improve the shelf life of the product.

4. The emulsion preparation method of the present invention is simple, does not require high pressure conditions, and the process is easy to control; the cost of raw materials used in the present invention is low, and common emulsifiers are used instead of phospholipid emulsifiers, and the same effect is achieved. The components of the emulsion act synergistically, so that the emulsion has the structure of lamellar liquid crystal, the droplet size is uniform, the stability is good, and it has the function of whitening and moisturizing.

Description of drawings

1 is an optical microscope image of the layered liquid crystal emulsion prepared in Example 4, a is a white light micrograph, and b is a polarized light micrograph;

FIG. 2 is a comparison curve of the water retention ratio of the layered liquid crystal emulsion prepared in Example 4 and the common emulsion.

3 is an optical microscope image of the layered liquid crystal emulsion prepared in Comparative Example 1, a is a white light micrograph, and b is a polarized light micrograph;

4 is an optical microscope image of the layered liquid crystal emulsion prepared in Comparative Example 2, a is a white light micrograph, and b is a polarized light micrograph;

5 is an optical microscope image of the layered liquid crystal emulsion prepared in Comparative Example 3, a is a white light micrograph, and b is a polarized light micrograph;

6 is an optical microscope image of the layered liquid crystal emulsion prepared in Comparative Example 4, a is a white light micrograph, and b is a polarized light micrograph.

specific implementation

The technical solutions of the present invention will be further described below in conjunction with specific implementation examples.

The test methods described in the examples are conventional methods unless otherwise specified; the reagents and raw materials used are commercially available unless otherwise specified.

In the embodiment, used glyceryl monostearate and castor oil are available from Shandong Yousuo Chemical Technology Co., Ltd.; Sodium Hyaluronate is available from Shandong Freda Bioengineering Co., Ltd.; Chamomile extract is available from Huzhou Jiamei Biochemical Products Co., Ltd. sells cetearyl alcohol, Guangzhou Suixin Chemical Co., Ltd. sells it.

Example 1

A whitening and moisturizing lotion containing lamellar liquid crystal, comprising the following raw materials by weight:

Caprylic/Capric Triglyceride 5g, Castor Oil 2g, Glycerol Monostearate 5g, Cetearyl Alcohol 5g, Beeswax 1.5g, 1,3-Butanediol 0.5g, Dimethicone 1g, Glycerin 12g, panthenol 1g, propylene glycol 1g, xanthan gum 0.5g, chamomile extract 0.5g, vitamin E 0.2g, vitamin C 0.2g, sodium hyaluronate 0.3g, niacinamide 0.5g, p-hydroxyacetophenone 0.1 g, disodium EDTA 0.1 g, purified water 63.6 g.

The preparation method of the whitening and moisturizing lotion containing lamellar liquid crystal comprises the following steps:

(1) Preparation of oil phase: according to the ratio of raw materials, mix oil phase, emulsifier, higher alcohol, beeswax, dimethylsiloxane, vitamin E and vitamin C, heat to 50°C, stir for 5 minutes, and obtain uniform mixing the oil phase;

(2) Preparation of water phase: add glycerin, propylene glycol, panthenol, sodium hyaluronate, nicotinamide, and p-hydroxyacetophenone to 31 g of purified water according to the ratio of raw materials, heat to 50°C, and stir for 5 minutes to obtain a mixed solution. homogeneous aqueous phase;

(3) prepare water-soluble polymer solution, disodium EDTA, xanthan gum, purified water 32.6g are stirred at normal temperature to obtain the mixed solution of water-soluble polymer;

(4) Mix the oil phase, the water phase and the water-soluble polymer solution at 50°C, and stir at 10000r/min for 10min;

(5) Slowly stirring the homogenized mixture, degassing and cooling, adding 0.5 g of chamomile extract during cooling, and stirring for another 1-2 hours to obtain a whitening and moisturizing emulsion containing lamellar liquid crystals uniformly and stably.

Example 2

A whitening and moisturizing lotion containing lamellar liquid crystal, comprising the following raw materials by weight:

Caprylic/Capric Triglyceride 5g, Castor Oil 2g, Glycerol Monostearate 5g, Cetearyl Alcohol 2g, Beeswax 1.5g, 1,3-Butanediol 0.5g, Dimethicone 1g, Glycerin 12g, panthenol 1g, propylene glycol 1g, xanthan gum 0.5g, chamomile extract 0.5g, vitamin E 0.2g, vitamin C 0.2g, sodium hyaluronate 0.5g, niacinamide 0.5g, p-hydroxyacetophenone 0.1 g, disodium EDTA 0.1 g, purified water 66.4 g.

The preparation method of the whitening and moisturizing lotion containing lamellar liquid crystal comprises the following steps:

(1) Preparation of oil phase: according to the ratio of raw materials, mix oil phase, emulsifier, higher alcohol, beeswax, dimethylsiloxane, vitamin E and vitamin C, heat to 50°C, stir for 5 minutes, and obtain uniform mixing the oil phase;

(2) Preparation of water phase: according to the ratio of raw materials, add glycerin, propylene glycol, panthenol, sodium hyaluronate, nicotinamide, and p-hydroxyacetophenone to 34 g of purified water, heat to 50° C., and stir for 5 minutes to obtain a mixed solution. homogeneous aqueous phase;

(3) prepare water-soluble polymer solution, disodium EDTA, xanthan gum, purified water 32.4g are stirred at normal temperature to obtain the mixed solution of water-soluble polymer;

(4) Mix the oil phase, the water phase and the water-soluble polymer solution at 50°C, and stir at 10000r/min for 10min;

(5) Slowly stirring the homogenized mixture, degassing and cooling, adding 0.5 g of chamomile extract during cooling, and stirring for another 1-2 hours to obtain a whitening and moisturizing emulsion containing lamellar liquid crystals uniformly and stably.

Example 3

A whitening and moisturizing lotion containing lamellar liquid crystal, comprising the following raw materials by weight:

Caprylic/Capric Triglyceride 5g, Castor Oil 2g, Glycerol Monostearate 7g, Cetearyl Alcohol 3g, Beeswax 1.5g, 1,3-Butanediol 1g, Dimethicone 1g, Glycerin 12g, panthenol 1g, propylene glycol 1g, xanthan gum 0.5g, chamomile extract 0.5g, vitamin E 0.2g, vitamin C 0.2g, sodium hyaluronate 0.5g, niacinamide 0.5g, p-hydroxyacetophenone 0.1g , EDTA disodium 0.1g, purified water 62.9g.

The preparation method of the whitening and moisturizing lotion containing lamellar liquid crystal comprises the following steps:

(1) Preparation of oil phase: according to the ratio of raw materials, mix oil phase, emulsifier, higher alcohol, beeswax, dimethylsiloxane, vitamin E and vitamin C, heat to 50°C, stir for 5 minutes, and obtain uniform mixing the oil phase;

(2) Preparation of aqueous phase: according to the ratio of raw materials, add glycerin, propylene glycol, panthenol, sodium hyaluronate, nicotinamide, and p-hydroxyacetophenone to 32.5 g of purified water, heat to 50 ° C, and stir for 5 min to obtain Mix the water phase evenly;

(3) prepare water-soluble polymer solution, disodium EDTA, xanthan gum, purified water 30.4g are stirred at normal temperature to obtain the mixed solution of water-soluble polymer;

(4) Mix the oil phase, the water phase and the water-soluble polymer solution at 50°C, and stir at 10000r/min for 10min;

(5) Slowly stirring the homogenized mixture, degassing and cooling, adding 0.5 g of chamomile extract during cooling, and stirring for another 1-2 hours to obtain a whitening and moisturizing emulsion containing lamellar liquid crystals uniformly and stably.

Example 4

A whitening and moisturizing lotion containing lamellar liquid crystal, comprising the following raw materials by weight:

Caprylic/Capric Triglyceride 5g, Castor Oil 2g, Glycerol Monostearate 5g, Cetearyl Alcohol 3g, Beeswax 1.5g, 1,3-Butanediol 1g, Dimethicone 1g, Glycerin 10g, Panthenol 1g, Propylene Glycol 0.5g, Xanthan Gum 0.5g, Chamomile Extract 0.5g, Vitamin E 0.2g, Vitamin C 0.2g, Sodium Hyaluronate 0.5g, Niacinamide 0.5g, Paraben Ketone 0.1g, disodium EDTA 0.1g, purified water 67.4g.

The preparation method of the whitening and moisturizing lotion containing lamellar liquid crystal comprises the following steps:

(1) Preparation of oil phase: according to the ratio of raw materials, mix oil phase, emulsifier, higher alcohol, beeswax, dimethylsiloxane, vitamin E and vitamin C, heat to 60°C, and stir for 5 minutes to obtain uniform mixing the oil phase;

(2) Preparation of water phase: according to the ratio of raw materials, add glycerin, propylene glycol, panthenol, sodium hyaluronate, nicotinamide, and p-hydroxyacetophenone to 37 g of purified water, heat to 60 ° C, and stir for 5 min to obtain a mixed solution. homogeneous aqueous phase;

(3) prepare water-soluble polymer solution, disodium EDTA, xanthan gum, purified water 30.4g are stirred at normal temperature to obtain the mixed solution of water-soluble polymer;

(4) Mix the oil phase, the water phase and the water-soluble polymer solution at 50°C, and stir at 10000r/min for 10min;

(5) Slowly stirring the homogenized mixture, degassing and cooling, adding 0.5 g of chamomile extract during cooling, and stirring for another 1-2 hours to obtain a whitening and moisturizing emulsion containing lamellar liquid crystals uniformly and stably.

The optical microscope image of the whitening and moisturizing emulsion containing lamellar liquid crystal prepared in this example is shown in FIG.

Example 5

A whitening and moisturizing lotion containing lamellar liquid crystal, comprising the following raw materials by weight:

Caprylic/Capric Triglyceride 5g, Castor Oil 2g, Glycerol Monostearate 5g, Cetearyl Alcohol 3g, Beeswax 1.5g, 1,3-Butanediol 1g, Dimethicone 1g, Glycerin 10g, panthenol 1g, propylene glycol 0.5g, xanthan gum 0.5g, chamomile extract 0.5g, vitamin E 0.2g, vitamin C 0.2g, sodium hyaluronate 0.5g, niacinamide 0.5g, p-hydroxyacetophenone 0.1 g, disodium EDTA 0.1 g, purified water 67.4 g.

The preparation method of the whitening and moisturizing lotion containing lamellar liquid crystal comprises the following steps:

(1) Preparation of oil phase: according to the ratio of raw materials, mix oil phase, emulsifier, higher alcohol, beeswax, dimethylsiloxane, vitamin E and vitamin C, heat to 60°C, and stir for 5 minutes to obtain uniform mixing the oil phase;

(2) Preparation of water phase: according to the ratio of raw materials, add glycerin, propylene glycol, panthenol, sodium hyaluronate, nicotinamide, and p-hydroxyacetophenone to 37 g of purified water, heat to 60 ° C, and stir for 5 min to obtain a mixed solution. homogeneous aqueous phase;

(3) prepare water-soluble polymer solution, disodium EDTA, xanthan gum, purified water 30.4g are stirred at normal temperature to obtain the mixed solution of water-soluble polymer;

(4) Mix the oil phase, the water phase and the water-soluble polymer solution at 60°C, and stir at 10000r/min for 10min;

(5) Slowly stirring the homogenized mixture, degassing and cooling, adding 0.5 g of chamomile extract during cooling, and stirring for another 1-2 hours to obtain a whitening and moisturizing emulsion containing lamellar liquid crystals uniformly and stably.

Example 6

A whitening and moisturizing lotion containing lamellar liquid crystal, comprising the following raw materials by weight:

Caprylic/Capric Triglyceride 5g, Castor Oil 2g, Glycerol Monostearate 5g, Cetearyl Alcohol 3g, Beeswax 1.5g, 1,3-Butanediol 1g, Dimethicone 1g, Glycerin 10g, panthenol 1g, propylene glycol 0.5g, xanthan gum 0.5g, chamomile extract 0.5g, vitamin E 0.2g, vitamin C 0.2g, sodium hyaluronate 0.5g, niacinamide 0.5g, p-hydroxyacetophenone 0.1 g, disodium EDTA 0.1 g, purified water 67.4 g.

The preparation method of the whitening and moisturizing lotion containing lamellar liquid crystal comprises the following steps:

(1) Preparation of oil phase: according to the ratio of raw materials, mix oil phase, emulsifier, higher alcohol, beeswax, dimethylsiloxane, vitamin E and vitamin C, heat to 70 ° C, stir for 5 minutes, and obtain uniform mixing the oil phase;

(2) Preparation of water phase: according to the ratio of raw materials, add glycerin, propylene glycol, panthenol, sodium hyaluronate, nicotinamide, and p-hydroxyacetophenone to 37 g of purified water, heat to 70° C., and stir for 5 minutes to obtain a mixed solution. homogeneous aqueous phase;

(3) prepare water-soluble polymer solution, disodium EDTA, xanthan gum, purified water 30.4g are stirred at normal temperature to obtain the mixed solution of water-soluble polymer;

(4) Mix the oil phase, the water phase and the water-soluble polymer solution at 70°C, and stir at 10000r/min for 10min;

(5) Slowly stirring the homogenized mixture, degassing and cooling, adding 0.5 g of chamomile extract during cooling, and stirring for another 1-2 hours to obtain a whitening and moisturizing emulsion containing lamellar liquid crystals uniformly and stably.

Example 7

A whitening and moisturizing lotion containing lamellar liquid crystal, comprising the following raw materials by weight:

Caprylic/Capric Triglyceride 5g, Castor Oil 2g, Glycerol Monostearate 5g, Cetearyl Alcohol 3g, Beeswax 1.5g, 1,3-Butanediol 1g, Dimethicone 1g, Glycerin 10g, panthenol 1g, propylene glycol 0.5g, xanthan gum 0.5g, chamomile extract 0.5g, vitamin E 0.2g, vitamin C 0.2g, sodium hyaluronate 0.5g, niacinamide 0.5g, p-hydroxyacetophenone 0.1 g, disodium EDTA 0.1 g, purified water 67.4 g.

The preparation method of the whitening and moisturizing lotion containing lamellar liquid crystal comprises the following steps:

(1) Preparation of oil phase: according to the ratio of raw materials, mix oil phase, emulsifier, higher alcohol, beeswax, dimethylsiloxane, vitamin E and vitamin C, heat to 50°C, stir for 5 minutes, and obtain uniform mixing the oil phase;

(2) Preparation of water phase: according to the ratio of raw materials, add glycerin, propylene glycol, panthenol, sodium hyaluronate, nicotinamide, and p-hydroxyacetophenone to 37 g of purified water, heat to 50° C., and stir for 5 minutes to obtain a mixed solution. homogeneous aqueous phase;

(3) prepare a water-soluble polymer solution, stir 0.1 g of disodium EDTA, 0.5 g of xanthan gum, and 30.4 g of purified water at normal temperature to obtain a mixed solution of water-soluble polymer;

(4) Mix the oil phase, the water phase and the water-soluble polymer solution at 50°C, and stir at 7000r/min for 10min;

(5) Slowly stirring the homogenized mixture, degassing and cooling, adding 0.5 g of chamomile extract during cooling, and stirring for another 1-2 hours to obtain a whitening and moisturizing emulsion containing lamellar liquid crystals uniformly and stably.

Example 8

A whitening and moisturizing lotion containing lamellar liquid crystal, comprising the following raw materials by weight:

Caprylic/Capric Triglyceride 5g, Castor Oil 2g, Glycerol Monostearate 5g, Cetearyl Alcohol 3g, Beeswax 1.5g, 1,3-Butanediol 1g, Dimethicone 1g, Glycerin 10g, panthenol 1g, propylene glycol 0.5g, xanthan gum 0.5g, chamomile extract 0.5g, vitamin E 0.2g, vitamin C 0.2g, sodium hyaluronate 0.5g, niacinamide 0.5g, p-hydroxyacetophenone 0.1 g, disodium EDTA 0.1 g, purified water 67.4 g.

The preparation method of the whitening and moisturizing lotion containing lamellar liquid crystal comprises the following steps:

(1) Preparation of oil phase: according to the ratio of raw materials, mix oil phase, emulsifier, higher alcohol, beeswax, dimethylsiloxane, vitamin E and vitamin C, heat to 50°C, stir for 5 minutes, and obtain uniform mixing the oil phase;

(2) Preparation of water phase: according to the ratio of raw materials, add glycerin, propylene glycol, panthenol, sodium hyaluronate, nicotinamide, and p-hydroxyacetophenone to 37 g of purified water, heat to 50° C., and stir for 5 minutes to obtain a mixed solution. homogeneous aqueous phase;

(3) prepare water-soluble polymer solution, disodium EDTA, xanthan gum, purified water 30.4g are stirred at normal temperature to obtain the mixed solution of water-soluble polymer;

(4) Mix the oil phase, the water phase and the water-soluble polymer solution at 50°C, and stir at 15000r/min for 10min;

(5) Slowly stirring the homogenized mixture, degassing and cooling, adding 0.5 g of chamomile extract during cooling, and stirring for 1-2 hours to obtain a uniform and stable whitening and moisturizing emulsion containing lamellar liquid crystals.

Comparative Example 1

An oil-in-water emulsion, the composition of raw materials by weight is as described in Example 1, except that: sorbitol is used instead of cetearyl alcohol; other raw materials and components are the same as in Example 1. The optical microscope image of the oil-in-water emulsion prepared by this comparative example is shown in FIG. 3 .

The preparation method is the same as that of Example 1.

Comparative Example 2

An oil-in-water emulsion, the composition of raw materials by weight is as described in Example 1, except that: olive oil is used instead of caprylic/capric triglyceride and castor oil; other raw materials and compositions are the same as in Example 1. The optical microscope image of the oil-in-water emulsion prepared by this comparative example is shown in FIG. 4 .

The preparation method is the same as that of Example 1.

Comparative Example 3

An oil-in-water emulsion, the composition of raw materials by weight is as shown in Example 1, the difference is: polysorbate-40 is used instead of glycerol monostearate; other raw materials and components are the same as those in Example 1. The optical microscope image of the oil-in-water emulsion prepared by this comparative example is shown in FIG. 5 .

The preparation method is the same as that of Example 1.

Comparative Example 4

An oil-in-water emulsion, the composition of raw materials by weight is as described in Example 1, the difference is: the addition of caprylic/capric triglyceride is 10 g; other raw materials and compositions are the same as in Example 1. The optical microscope image of the oil-in-water emulsion prepared by this comparative example is shown in FIG. 6 .

The preparation method is the same as that of Example 1.

Test Example 1

Using optical microscope images as a comparison, the particle size distribution, the integrity of the lamellar liquid crystal and the number of lamellar liquid crystals of the emulsions under different formulations were compared. Optical microscope images were observed with a polarizing microscope, where a capillary was dipped in a certain amount of emulsion, placed on a glass slide, and then covered with a coverslip. The white light and polarized light microscopic images of the emulsion were observed at different magnifications and different positions. The test results are shown in Table 1 below.

Table 1 Particle size distribution of emulsion and morphology of lamellar liquid crystal

Sample serial number Particle size distribution The number of layered liquid crystals lamellar liquid crystal morphology Example 1 uniform many whole Comparative Example 1 uniform none none Comparative Example 2 uniform few incomplete Comparative Example 3 uniform none none Comparative Example 4 uneven many whole

By comparison, it can be found that with the increase of emulsifier content, the viscosity of the system increases. Under the same rotation speed, the emulsion system cannot be well dispersed, so the particle size of the emulsion increases and the distribution is uneven; changing the emulsifier , the lamellar liquid crystal disappears in the system, indicating that the type of emulsifier plays a key role in the formation of lamellar liquid crystal; changing the oil phase, the lamellar liquid crystal also decreases, which is mainly due to the different hydrophobic effects of different oil phases; When the higher alcohol is changed, the lamellar liquid crystal disappears, mainly because the length of the carbon chain without the higher alcohol is different, and the chain length is the same or close to the carbon chain length of the emulsifier, and it is easier to form the lamellar liquid crystal.

Claims (2)

1. A whitening and moisturizing emulsion containing lamellar liquid crystal comprises the following raw materials in parts by weight:

5g of caprylic/capric triglyceride, 2g of castor oil, 5g of glyceryl monostearate, 3g of cetostearyl alcohol, 1.5g of beeswax, 1g of 1, 3-butanediol, 1g of dimethyl siloxane, 10g of glycerol, 1g of panthenol, 0.5g of propylene glycol, 0.5g of xanthan gum, 0.5g of chamomile extract, 0.2g of vitamin E, 0.2g of vitamin C, 0.5g of sodium hyaluronate, 0.5g of nicotinamide, 0.1g of p-hydroxyacetophenone, 0.1g of disodium EDTA and 67.4g of refined water;

the preparation method of the whitening and moisturizing emulsion containing the lamellar liquid crystal comprises the following steps:

(1) preparing an oil phase: mixing caprylic/capric triglyceride, castor oil, glyceryl monostearate, cetostearyl alcohol, beeswax, dimethyl siloxane, vitamin E and vitamin C according to the raw material ratio, heating to 60 ℃, and stirring for 5min to obtain a uniformly mixed oil phase;

(2) preparation of the aqueous phase: adding glycerol, 1, 3-butanediol, propylene glycol, panthenol, sodium hyaluronate, nicotinamide and p-hydroxyacetophenone into 37g of refined water, heating to 60 deg.C, and stirring for 5min to obtain uniformly mixed water phase;

(3) preparing a water-soluble polymer solution, namely stirring disodium EDTA, xanthan gum and 30.4g of refined water at normal temperature to obtain a mixed solution of the water-soluble polymer;

(4) mixing the oil phase, the water phase and the water-soluble polymer solution at 50 ℃, and stirring at 10000r/min for 10 min;

(5) and slowly stirring the homogenized mixture, degassing and cooling, adding 0.5g of chamomile extract in the cooling process, and stirring for 1-2 hours to obtain the uniform and stable whitening and moisturizing emulsion containing the lamellar liquid crystal.

2. A whitening and moisturizing emulsion containing lamellar liquid crystal comprises the following raw materials in parts by weight:

5g of caprylic/capric triglyceride, 2g of castor oil, 5g of glyceryl monostearate, 2g of cetostearyl alcohol, 1.5g of beeswax, 0.5g of 1, 3-butanediol, 1g of dimethyl siloxane, 12g of glycerol, 1g of panthenol, 1g of propylene glycol, 0.5g of xanthan gum, 0.5g of chamomile extract, 0.2g of vitamin E, 0.2g of vitamin C, 0.5g of sodium hyaluronate, 0.5g of nicotinamide, 0.1g of p-hydroxyacetophenone, 0.1g of disodium EDTA and 66.4g of refined water;

the preparation method of the whitening and moisturizing emulsion containing the lamellar liquid crystal comprises the following steps:

(1) preparing an oil phase: mixing caprylic/capric triglyceride, castor oil, glyceryl monostearate, cetostearyl alcohol, beeswax, dimethyl siloxane, vitamin E and vitamin C according to the raw material ratio, heating to 50 ℃, and stirring for 5min to obtain a uniformly mixed oil phase;

(2) preparation of the aqueous phase: adding glycerol, 1, 3-butanediol, propylene glycol, panthenol, sodium hyaluronate, nicotinamide and p-hydroxyacetophenone into 34g of refined water, heating to 50 ℃, and stirring for 5min to obtain a uniformly mixed water phase;

(3) preparing a water-soluble polymer solution, namely stirring disodium EDTA, xanthan gum and 32.4g of refined water at normal temperature to obtain a mixed solution of a water-soluble polymer;

(4) mixing the oil phase, the water phase and the water-soluble polymer solution at 50 ℃, and stirring at 10000r/min for 10 min;

(5) and slowly stirring the homogenized mixture, degassing and cooling, adding 0.5g of chamomile extract in the cooling process, and stirring for 1-2 hours to obtain the uniform and stable whitening and moisturizing emulsion containing the lamellar liquid crystal.

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