CN111436972A - Three-dimensional ultrasonic gynecological disease diagnosis device - Google Patents
Three-dimensional ultrasonic gynecological disease diagnosis device Download PDFInfo
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Abstract
The invention discloses a three-dimensional ultrasonic gynecological disease diagnosis device, which comprises a diagnosis device host, a mechanical scanning mechanism and a detection probe, wherein the detection probe is driven by the mechanical scanning mechanism to automatically scan; an ultrasonic probe and an optical lens are arranged in the detection probe and are respectively used for acquiring a two-dimensional ultrasonic image and an optical image of a patient; the diagnosis device host is internally provided with a gynecological disease diagnosis system for controlling the mechanical scanning mechanism and processing and analyzing the acquired ultrasonic image and optical image. By the mode, the detection probe can be accurately controlled to carry out intracavity ultrasonic diagnosis, so that the obtained two-dimensional image has position information, and three-dimensional reconstruction is conveniently and accurately carried out; the invention can also fuse the optical image and the ultrasonic image, effectively improve the resolution of the ultrasonic image, thereby obtaining a finer tissue structure, more accurately segmenting and extracting the lesion area and realizing the accurate diagnosis of gynecological diseases.
Description
Technical Field
The invention relates to the technical field of ultrasonic diagnosis, in particular to a three-dimensional ultrasonic gynecological disease diagnosis device.
Background
Gynecological diseases, which are common diseases and frequently encountered diseases of women, need to be treated effectively in time so as to avoid the influence of prolonged or worsened course of disease on patients. But because many diseases in the gynecological diseases do not have specific symptoms, timely effective and accurate diagnosis has important significance for discovery and treatment of the diseases. In various clinical diagnosis methods of gynecological diseases, the ultrasonic diagnosis in the cavity is widely applied as an effective examination means which is noninvasive, painless, convenient and intuitive.
At present, two-dimensional ultrasonic diagnosis is commonly adopted clinically to effectively acquire images of lesion positions, but the image definition is poor, so that the diagnosis effect on tiny lesions is poor, the phenomena of missed diagnosis, misdiagnosis and the like are caused, and the treatment of diseases is influenced. Therefore, the three-dimensional ultrasound technology with relatively higher definition and capable of displaying the condition between the diseased region and the surrounding tissue more intuitively has gradually received attention of people, and how to use the three-dimensional ultrasound technology to perform accurate and effective disease diagnosis on a patient is the current research focus.
The patent with publication number CN109350111A provides an image data integration system and method for ultrasound, which evaluates the disease condition of a patient by establishing a three-dimensional model, a lesion marker and lesion contrast with collected two-dimensional ultrasound image information of the patient, so as to accurately judge and determine the location and degree of the lesion of the patient, and facilitate medical staff to diagnose the disease of the patient. However, the acquisition of the clinical ultrasound image information is mainly obtained by a doctor holding an ultrasound probe for detection, so that the problems of unstable operation and poor consistency exist, and the two-dimensional ultrasound images of all sections are difficult to accurately acquire, so that the difficulty and the accuracy of the obtained two-dimensional ultrasound image are high when a three-dimensional model is established, and the accuracy of the final diagnosis result is affected.
In addition, because of the variety of gynecological diseases, not only do some clinical symptoms show no obvious specificity, but also the ultrasound images of some diseases are similar, so that the diagnosis of gynecological diseases based on the ultrasound images is still difficult to accurately identify the disease types, and the diagnosis result is not accurate and comprehensive.
In view of this, there is still a need to provide a more accurate and comprehensive three-dimensional ultrasonic gynecological disease diagnosis device, so as to diagnose gynecological diseases more accurately and assist medical staff in diagnosing and treating patients timely and effectively.
Disclosure of Invention
The invention aims to solve the problems and provides a three-dimensional ultrasonic gynecological disease diagnosis device, wherein an optical lens is additionally arranged on an ultrasonic probe to form a detection probe, and a mechanical scanning mechanism is arranged to accurately control the detection probe to carry out intracavity ultrasonic diagnosis, so that the obtained two-dimensional ultrasonic image and optical image have position information, and three-dimensional reconstruction is facilitated; the optical image and the ultrasonic image can be fused by utilizing a gynecological disease diagnosis system arranged in the device host, so that the resolution of the ultrasonic image is effectively improved, a more precise tissue structure is obtained, a lesion area is more accurately segmented and extracted, and the gynecological disease is accurately diagnosed.
In order to achieve the purpose, the invention provides a three-dimensional ultrasonic gynecological disease diagnosis device, which comprises a diagnosis device host, a mechanical scanning mechanism and a detection probe, wherein the mechanical scanning mechanism is in communication connection with the diagnosis device host, and the detection probe is electrically connected with the diagnosis device host; the mechanical scanning mechanism is fixed on the detection bed, and the detection probe is detachably arranged on the mechanical scanning mechanism and is used for carrying out automatic scanning under the driving of the mechanical scanning mechanism; an ultrasonic probe and an optical lens are arranged in the detection probe and are respectively used for acquiring a two-dimensional ultrasonic image and an optical image of a patient; the diagnosis device host is internally provided with a gynecological disease diagnosis system for controlling the mechanical scanning mechanism and carrying out image processing and analysis on the acquired ultrasonic images and optical images.
Further, the mechanical scanning mechanism comprises a translation mechanism and a mechanical arm, the translation mechanism comprises a vertical slide rail, a support plate and a slide block, and the mechanical arm is fixedly connected with the slide block; the two vertical slide rails are respectively fixed on two sides of the detection bed and are parallel to the lying direction of the patient; the supporting plate is parallel to the bed surface of the detection bed and is perpendicular to the vertical sliding rail; two pulleys are respectively arranged on the supporting plate and parallel to two ends of the vertical sliding rail, and the pulleys are embedded into the vertical sliding rail and roll along the vertical sliding rail; two horizontal sliding rails are respectively arranged on the two sides of the supporting plate, which are perpendicular to the vertical sliding rails; the slider is arranged on the supporting plate and is in sliding connection with the horizontal sliding rail.
Further, the mechanical arm is a six-degree-of-freedom mechanical arm which is fixed on the upper surface of the sliding block, and a clamping mechanism is arranged at the tail end of the six-degree-of-freedom mechanical arm; the clamping mechanism comprises a motor and a clamp, the motor is detachably mounted at the tail end of the six-degree-of-freedom mechanical arm, the driving end of the motor is connected with the clamp, and the clamp is used for clamping the detection probe.
Further, the detection probe comprises an ultrasonic probe, an optical lens, a light guide optical fiber and a transparent shell; the ultrasonic probe and the optical lens face in the same direction, the light guide optical fiber is coated on the outer surfaces of the ultrasonic probe and the optical lens, and the transparent shell is coated on the outer surface of the light guide optical fiber.
Furthermore, the gynecological disease diagnosis system comprises an image acquisition module, an image processing module, a disease diagnosis module and an output module which are connected in sequence; the image acquisition module is connected with the detection probe and is used for acquiring image information acquired by the detection probe; the image processing module is used for processing the image acquired by the image acquisition module to acquire corresponding image characteristics; the disease diagnosis module is used for automatically identifying and classifying the image characteristics acquired by the image processing module and obtaining a diagnosis result; the output module is connected with the display screen and used for outputting and displaying the diagnosis result obtained by the disease diagnosis module.
Further, the gynecological disease diagnosis system also comprises a control module, wherein the control module comprises a main control unit and a scanning control unit; the main control unit is respectively connected with the scanning control unit, the image acquisition module, the image processing module, the disease diagnosis module and the output module and is used for controlling the normal operation of each module or unit; the scanning control unit is in communication connection with the mechanical scanning mechanism and is used for controlling the motion state of the mechanical scanning mechanism.
Further, the image acquisition module comprises an ultrasonic image acquisition unit, an optical image acquisition unit and a position information matching unit; the ultrasonic image acquisition unit is connected with the ultrasonic probe and is used for acquiring a two-dimensional ultrasonic image; the optical image acquisition unit is connected with the optical lens and is used for acquiring a two-dimensional optical image in the uterine cavity; the position information matching unit is respectively connected with the ultrasonic image acquisition unit, the optical image acquisition unit and the scanning control unit and is used for matching the motion information provided by the scanning control unit with the image information acquired by the ultrasonic image acquisition unit and the optical image acquisition unit, so that the information output by the image acquisition module comprises the image information and the position information.
Further, the image processing module comprises a preprocessing unit, a three-dimensional reconstruction unit, an image fusion unit and a feature extraction unit which are connected in sequence; the preprocessing unit is used for carrying out filtering and denoising, image enhancement and image scaling processing on the image information input by the image acquisition module; the three-dimensional reconstruction unit is used for converting the preprocessed image information and position information into three-dimensional volume data, reconstructing a three-dimensional image of a uterine cavity, and respectively outputting an ultrasonic image and an optical image of a sagittal plane, a coronal plane and a cross section of the uterus; the image fusion unit is used for fusing the optical image output by the three-dimensional reconstruction unit into a corresponding ultrasonic image to obtain a fused ultrasonic image; the feature extraction unit performs image segmentation and focus feature extraction on the fused ultrasonic image, wherein the focus features comprise morphological features, distribution features, edge features, texture features and echo features.
Further, the disease diagnosis module comprises a model training unit and a disease classification unit; the model training unit is used for training a neural network model based on focus characteristics of a training sample, and the disease classification unit is used for automatically classifying the focus characteristics output by the image processing module based on the neural network model trained by the model training unit and outputting disease categories; the disease categories include uterine malformations, endometrial polyps, endometrial hyperplasia, uterine fibroids and endometrial cancer, the endometrial hyperplasia categories include simple hyperplasia, compound hyperplasia and atypical hyperplasia, the uterine fibroids categories include submucosal fibroids, intermuscular fibroids and submucosal fibroids.
Furthermore, the gynecological disease diagnosis system also comprises a storage module, wherein the storage module is connected with the control module and is used for storing the acquired image information, the output diagnosis information and the motion path information of the mechanical scanning mechanism.
Compared with the prior art, the invention has the beneficial effects that:
1. according to the three-dimensional ultrasonic gynecological disease diagnosis device provided by the invention, the optical lens is additionally arranged on the ultrasonic probe to form the detection probe, and the mechanical scanning mechanism is arranged to accurately control the detection probe to carry out intracavity ultrasonic diagnosis, so that the obtained two-dimensional ultrasonic image and the optical image have position information, and three-dimensional reconstruction is conveniently and accurately carried out; the optical image and the ultrasonic image can be fused by utilizing a gynecological disease diagnosis system arranged in the device host, so that the resolution of the ultrasonic image is effectively improved, a more precise tissue structure is obtained, a lesion area is more accurately segmented and extracted, and the gynecological disease is accurately diagnosed.
2. The mechanical scanning mechanism comprising the translation mechanism and the mechanical arm is arranged to control the motion of the detection probe, so that the motion condition of the detection probe in the detection process can be accurately controlled, the acquired image has position information, and the three-dimensional reconstruction can be accurately and efficiently performed; the original probe detection path can be repeated during the patient review, and targeted examination and comparison can be performed. Meanwhile, the invention can also utilize the large-range movement effect of the translation mechanism, solve the problems of small movement range and inconvenient operation of a single mechanical arm and ensure that the detection process is more convenient and efficient. In addition, the clamp is connected with the driving end of the motor, so that the detection probe can be controlled to select, rotary scanning can be conveniently carried out, and the detection mode is more comprehensive.
3. According to the invention, the detection probe simultaneously comprising the ultrasonic probe and the optical lens is arranged, and the gynecological disease diagnosis system comprising the image fusion unit is arranged to fuse the ultrasonic image and the optical image, so that the optical image is fused into the corresponding ultrasonic image by utilizing the characteristic of high resolution of the optical image obtained by the optical lens, the resolution of the ultrasonic image obtained after fusion is effectively improved, the fused ultrasonic image has more clear tissue details, the problem that partial diseases are difficult to effectively distinguish due to low resolution of the traditional ultrasonic image is solved, the classification of gynecological diseases is convenient to more accurately and finely divide, and the diagnosis result is more accurate and comprehensive.
4. The gynecological disease diagnosis system provided by the invention can not only carry out three-dimensional reconstruction and image fusion on the acquired ultrasonic image and optical image, but also train sample data by establishing a neural network model, realize automatic diagnosis on gynecological diseases and greatly improve the detection efficiency; the three-dimensional ultrasonic gynecological disease diagnosis device provided by the invention is easy to operate, convenient to use, accurate and efficient in diagnosis process, and can meet the requirements of practical application.
Drawings
FIG. 1 is a schematic structural diagram of a three-dimensional ultrasonic gynecological disease diagnosis device provided by the present invention;
FIG. 2 is a top view of the translation mechanism in the three-dimensional ultrasonic gynecological disease diagnosis device provided by the present invention;
FIG. 3 is a schematic cross-sectional view of a detection probe in the three-dimensional ultrasonic gynecological disease diagnosis device provided by the present invention;
FIG. 4 is a schematic diagram of a gynecological disease diagnosis system in the three-dimensional ultrasonic gynecological disease diagnosis device provided by the present invention;
the parts in the drawings are numbered as follows: 1. a diagnostic device host; 11. a display screen; 12. a connecting wire; 21. a vertical slide rail; 22. a pulley; 23. a support plate; 24. a horizontal slide rail; 25. a slider; 26. a six-degree-of-freedom mechanical arm; 27. a motor; 28. a clamp; 3. detecting a probe; 31. an ultrasonic probe; 32. an optical lens; 33. a light guide optical fiber; 34. a transparent housing; 4. and (4) detecting the bed.
Detailed Description
The following detailed description of the preferred embodiments of the present invention, taken in conjunction with the accompanying drawings, will make the advantages and features of the invention easier to understand by those skilled in the art, and thus will clearly and clearly define the scope of the invention. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present invention without any inventive step, are within the scope of the present invention.
Examples
Referring to fig. 1, an embodiment of the present invention provides a three-dimensional ultrasonic gynecological disease diagnosis apparatus, including a diagnosis apparatus host 1, a mechanical scanning mechanism and a detection probe 3, where the mechanical scanning mechanism and the diagnosis apparatus host 1 establish a communication connection based on a TCP/IP communication protocol, and the detection probe is electrically connected to the diagnosis apparatus host through a connection line 12; the mechanical scanning mechanism is fixed on the detection bed 4, and the detection probe 3 is detachably mounted on the mechanical scanning mechanism and is used for automatic scanning under the driving of the mechanical scanning mechanism; an ultrasonic probe 31 and an optical lens 32 are arranged in the detection probe 3 and are respectively used for acquiring a two-dimensional ultrasonic image and an optical image of a patient; the diagnosis device host 1 is internally provided with a gynecological disease diagnosis system for controlling the mechanical scanning mechanism and processing and analyzing the acquired ultrasonic images and optical images.
In conjunction with fig. 2, the mechanical scanning mechanism comprises a translation mechanism comprising a vertical slide rail 21, a support plate 23 and a slide 25, and a six-degree-of-freedom mechanical arm 26; two vertical slide rails 21 are respectively fixed on two sides of the detection bed 4 and are parallel to the lying direction of the patient; the supporting plate 23 is parallel to the bed surface of the detection bed 4 and is arranged perpendicular to the vertical slide rail 21; two pulleys 22 are respectively arranged on the supporting plate 23 parallel to two ends of the vertical slide rail, and the pulleys 22 are embedded in the vertical slide rail 21 and roll along the vertical slide rail 21, so that the supporting plate 23 is driven to slide along the vertical slide rail 21; two horizontal sliding rails 24 are respectively arranged on the supporting plate 23 and are perpendicular to the two sides of the vertical sliding rail 21; the sliding block 25 is arranged on the supporting plate 23 and is connected with the horizontal sliding rail 24 in a sliding manner; the six-degree-of-freedom mechanical arm 26 is fixed on the upper surface of the sliding block 25 and is driven by the sliding block to slide along the horizontal sliding rail 24. The tail end of the six-degree-of-freedom mechanical arm 26 is provided with a clamping mechanism; the clamping mechanism comprises a motor 27 and a clamp 28, the motor 27 is detachably mounted at the tail end of the six-degree-of-freedom mechanical arm 26, and the driving end of the motor 27 is connected with the clamp 28 and used for driving the clamp 28 to rotate; the clamp 28 is used for clamping the detection probe 3.
Referring to fig. 3 in combination, the detection probe 3 includes an ultrasonic probe 31, an optical lens 32, a light guide fiber 33 and a transparent casing 34; the orientations of the ultrasonic probe 31 and the optical lens 32 are the same, and the light guide fiber 33 is coated on the outer surfaces of the ultrasonic probe 31 and the optical lens 32 and used for providing light for the optical lens 32 so as to facilitate the collection of clear optical images; the transparent casing 34 covers the outer surface of the light guide fiber 33, and is used for protecting the light guide fiber 33 and ensuring light to pass through.
With reference to fig. 4, the gynecological disease diagnosis system in the three-dimensional ultrasonic gynecological disease diagnosis device provided in this embodiment includes an image acquisition module, an image processing module, a disease diagnosis module, and an output module, which are connected in sequence; the image acquisition module is connected with the detection probe and is used for acquiring image information acquired by the detection probe 3; the image processing module is used for processing the image acquired by the image acquisition module to acquire corresponding image characteristics; the disease diagnosis module is used for automatically identifying and classifying the image characteristics acquired by the image processing module and obtaining a diagnosis result; the output module is connected with the display screen 11 and is used for outputting and displaying the diagnosis result obtained by the disease diagnosis module.
The gynecological disease diagnosis system also comprises a control module and a storage module, wherein the control module comprises a main control unit and a scanning control unit; the main control unit is respectively connected with the scanning control unit, the storage module, the image acquisition module, the image processing module, the disease diagnosis module and the output module and is used for controlling the normal operation of each module or unit; the scanning control unit is in communication connection with the mechanical scanning mechanism and is used for controlling the motion state of the mechanical scanning mechanism; the storage module is used for storing the acquired image information, the output diagnosis information and the motion path information of the mechanical scanning mechanism.
Specifically, the image acquisition module comprises an ultrasonic image acquisition unit, an optical image acquisition unit and a position information matching unit; the ultrasonic image acquisition unit is connected with the ultrasonic probe 31 and is used for acquiring a two-dimensional ultrasonic image; the optical image acquisition unit is connected with the optical lens 32 and is used for acquiring a two-dimensional optical image in the uterine cavity; the position information matching unit is respectively connected with the ultrasonic image acquisition unit, the optical image acquisition unit and the scanning control unit and is used for matching the motion information provided by the scanning control unit with the image information acquired by the ultrasonic image acquisition unit and the optical image acquisition unit, so that the information output by the image acquisition module comprises the image information and the position information.
The image processing module comprises a preprocessing unit, a three-dimensional reconstruction unit, an image fusion unit and a feature extraction unit which are sequentially connected; the preprocessing unit is used for carrying out filtering and denoising, image enhancement and image scaling processing on the image information input by the image acquisition module; the three-dimensional reconstruction unit is used for converting the preprocessed image information and position information into three-dimensional volume data, reconstructing a three-dimensional image of a uterine cavity, and respectively outputting an ultrasonic image and an optical image of a sagittal plane, a coronal plane and a cross section of the uterus; the image fusion unit is used for fusing the optical image output by the three-dimensional reconstruction unit into a corresponding ultrasonic image to obtain a fused ultrasonic image; the feature extraction unit performs image segmentation and focus feature extraction on the fused ultrasonic image, wherein the focus features comprise morphological features, distribution features, edge features, texture features and echo features.
The disease diagnosis module comprises a model training unit and a disease classification unit; the model training unit is used for training a neural network model based on focus characteristics of a training sample, and the disease classification unit is used for automatically classifying the focus characteristics output by the image processing module based on the neural network model trained by the model training unit and outputting disease categories; the disease categories include uterine malformations, endometrial polyps, endometrial hyperplasia, uterine fibroids and endometrial cancer, the endometrial hyperplasia categories include simple hyperplasia, compound hyperplasia and atypical hyperplasia, the uterine fibroids categories include submucosal fibroids, intermuscular fibroids and submucosal fibroids.
The three-dimensional ultrasonic gynecological disease diagnosis device provided by the invention can start disease diagnosis after being started, and specifically comprises the following steps:
s1, image acquisition
A patient can take the bladder stones and lie on the detection bed, a doctor firstly moves the supporting plate 23 along the vertical slide rail 21 and then moves the sliding block 25 along the horizontal slide rail 24, so that the detection probe 3 at the tail end of the six-degree-of-freedom mechanical arm 26 is positioned at the vaginal opening of the patient, and then the movement of the six-degree-of-freedom mechanical arm 26 is controlled through an operation panel on a diagnosis device host machine to carry out ultrasonic scanning in the vaginal cavity; in the scanning process, a doctor can control the motor 27 to drive the detection probe 2 to perform rotary scanning according to needs so as to obtain images with different needs.
After the two-dimensional ultrasonic image and the two-dimensional optical image acquired by the detection probe are respectively received by the ultrasonic image acquisition unit and the optical image acquisition unit, the position information matching unit is input, the movement conditions of the six-degree-of-freedom mechanical arm 26 and the motor 27 in the scanning process are matched with the acquired ultrasonic image and optical image by the position information matching unit, so that each image has corresponding position information, and the image information and the position information are input into the image processing module.
S2, image processing
Specifically, in the embodiment, the size of the ultrasound image and the optical image after the scaling processing is set to be 512 × 512, the gray value normalization is set to be [0,1], and the parameters can be adjusted as required in other embodiments.
Inputting the preprocessed image information and the corresponding position information into a three-dimensional reconstruction unit for three-dimensional reconstruction, wherein the three-dimensional reconstruction process comprises the following steps:
s21, arranging the two-dimensional image information input into the three-dimensional reconstruction unit according to the corresponding position information to form an image sequence;
s22, performing linear interpolation on pixel values corresponding to adjacent images in the image sequence by adopting a linear gray scale interpolation method to obtain gray scale data corresponding to each adjacent image, thereby obtaining three-dimensional volume data consisting of cubic gray scale values;
s23, constructing a three-dimensional image of the uterine cavity based on the three-dimensional volume data obtained in the step S22, wherein the three-dimensional image of the uterine cavity comprises a three-dimensional ultrasonic image and a three-dimensional optical image;
and S24, performing multi-plane imaging on the three-dimensional image of the uterine cavity obtained in the step S23 to obtain an ultrasonic image and an optical image of the three-dimensional image of the uterine cavity in a sagittal plane, a coronal plane and a cross section of the uterus, and outputting the ultrasonic image and the optical image to an image fusion unit.
And then the image fusion unit fuses the ultrasonic image and the optical image corresponding to the same section, wherein the fusion method comprises the following steps:
extracting the gray value of each pixel point on the ultrasonic image and the optical image, and extracting the gray value g of the pixel point (i, j) on the ultrasonic imagea(i, j) the gray value g of the pixel point (i, j) at the same position on the corresponding optical imageb(i, j) are overlapped according to a certain proportion coefficient to obtain the gray value g of the pixel point (i, j) on the fused ultrasonic imagecAnd (i, j), so as to obtain a fused ultrasonic image according to the gray value of each pixel point after fusion. In this embodiment, gc(i,j)＝0.75ga(i,j)+0.25gb(i, j), under the condition, the obtained fusion ultrasonic image can increase the surface detail characteristics of the uterine cavity under the condition of fully retaining the original ultrasonic characteristics, the resolution ratio of the fusion ultrasonic image is improved, and a more precise tissue structure is convenient to obtain, so that the lesion area is more accurately segmented and extracted, and the gynecological diseases are accurately diagnosed.
The fused ultrasonic image obtained by the method is input to the feature extraction unit by the image fusion unit, the input fused ultrasonic image is segmented by the feature extraction unit according to different gray threshold values, and images corresponding to the myometrium, endometrium and other tissues are respectively extracted; and then, a feature extraction unit extracts focus features of the segmented image, wherein the focus features comprise morphological features, distribution features, edge features, texture features and echo features.
In particular, the morphological feature comprises the shape S of the uterine profile0With volume V0Thickness of endometrium H0And other abnormal tissue shapes SiWith volume Vi. Wherein the shape S of the uterine profile or other tissueiAnd (3) judging according to the eccentricity of the corresponding image contour: the closer the eccentricity is to 1, the closer the contour shape of the tissue is to an ellipse; the closer the eccentricity is to 0, the closer the contour shape of the tissue is to circular. Volume V of uterus or other tissueiThen the image resolution is multiplied by the number of mask pixels corresponding to the tissue.
The distribution characteristics are used for describing the distribution condition of abnormal tissues except normal tissues such as myometrium, endometrium and the like in the uterus, including the quantity i of the abnormal tissues and the coordinates C of the central point thereofi(a,b)。
The edge feature is used for describing the contour smoothing condition of the abnormal tissue and is formed by a correlation coefficient Ri 2Carrying out characterization; the correlation coefficient Ri 2The calculation formula of (a) is as follows:
in the above formula, n is the number of pixel points on the tissue contour, biIs the ordinate, B, of each pixel point on the tissue contouriThe vertical coordinates of the corresponding pixel points on the fitting curve obtained according to the organization contour line. Wherein the fitting curve is obtained by fitting according to a least square method.
The texture features are used for describing the surface texture condition of abnormal tissues and are extracted through a gray level co-occurrence matrix, and the extracted feature data comprise angle second moment MiAnd contrast ratio Ni. Wherein the second moment of angle MiUsed for describing the uniformity of the texture on the surface of the tissue, and the calculation formula is Mi＝∑a∑b[p(a,b)]2(ii) a The contrast is used for describing the definition of the texture of the tissue surface, and the calculation formula is Ni＝∑a∑b(a,b)2p (a, b); in the formula, (a, b) is any pixel point on the tissue image, and p (a, b) is the pixel value of the pixel point.
The echo feature is used for describing the echo condition of the abnormal tissue and is composed of an image gray value GiAnd (6) performing characterization.
By extracting the focus characteristics such as the morphological characteristics, the distribution characteristics, the edge characteristics, the texture characteristics and the echo characteristics, the characteristic extraction unit extracts the focus characteristics
And outputting the focus characteristic vector to a disease diagnosis module.
S3 disease diagnosis
After a disease classification unit of the disease diagnosis module receives the focus feature vectors output by the feature extraction unit, automatically classifying the focus feature vectors by using a neural network model, wherein the classification process comprises a disease large-class rough classification process and a disease feature subdivision process; the classification result obtained in the rough classification process comprises normal, uterine malformation, endometrial polyp, endometrial hyperplasia, hysteromyoma and endometrial carcinoma, and when the rough classification result is normal, uterine malformation, endometrial polyp or endometrial carcinoma, the classification is directly finished, and a diagnosis result is output; when the results of rough classification are endometrial hyperplasia and hysteromyoma, further subdivision is carried out: the fine categories of endometrial hyperplasia include simple hyperplasia, compound hyperplasia and atypical hyperplasia, and the fine categories of uterine fibroids include submucosal fibroids, intermuscular fibroids and submucosal fibroids.
The neural network model needs to be trained in advance, and the training process comprises the following steps:
s31, acquiring an intracavity ultrasonic image of the patient from a hospital; the types of the patients include uterine malformation, endometrial polyp, endometrial hyperplasia, uterine fibroids and endometrial cancer, and 2000 ultrasonic images are selected as training samples for various diseases;
s32, extracting the focus characteristics of each training sample according to the same method as the detection sample;
s33, constructing a neural network model, inputting the focus feature vectors from a first input end of the neural network model, and outputting six classification results of normal, uterine malformation, endometrial polyp, endometrial hyperplasia, uterine fibroid and endometrial cancer by a first output layer; and inputting the result of the first output layer into a second input layer for result detection, so that the result classified as normal, uterine malformation, endometrial polyp or endometrial cancer is directly output by the second output layer, and the result classified as endometrial hyperplasia and uterine fibroid is further classified and then output. The above training processes all adopt loss functions to perform supervised training.
With the use of the three-dimensional ultrasonic gynecological disease diagnosis device provided by the embodiment, more detection data can be obtained and stored in the storage module, and the new detection data can be periodically used for training instead of the original training data, so that the accuracy of the neural network module is improved.
S4, outputting the result
The output module identifies the disease classification result output by the disease diagnosis module, and displays the detection image and the disease diagnosis result through the display screen, so that a doctor can observe conveniently; also can be connected with a printer for printout, and is convenient for doctors and patients to store.
By the mode, the three-dimensional ultrasonic gynecological disease diagnosis device provided by the invention can accurately control the detection probe to carry out intracavity ultrasonic diagnosis, so that the obtained two-dimensional image has position information, and three-dimensional reconstruction is conveniently and accurately carried out; the optical image and the ultrasonic image can be fused, so that the resolution of the ultrasonic image is effectively improved, a more refined tissue structure is obtained, the categories of gynecological diseases are more accurately and finely divided, and the diagnosis result is more accurate and comprehensive. In addition, the invention can realize the automatic diagnosis of gynecological diseases, thereby greatly improving the detection efficiency; the three-dimensional ultrasonic gynecological disease diagnosis device provided by the invention is easy to operate, convenient to use, accurate and efficient in diagnosis process, and can meet the requirements of practical application.
The above description is only for the purpose of illustrating the technical solutions of the present invention and is not intended to limit the same; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; all the equivalent structures or equivalent processes performed by using the contents of the specification and the drawings of the invention, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (10)
1. The three-dimensional ultrasonic gynecological disease diagnosis device is characterized by comprising a diagnosis device host, a mechanical scanning mechanism and a detection probe, wherein the mechanical scanning mechanism is in communication connection with the diagnosis device host, and the detection probe is electrically connected with the diagnosis device host; the mechanical scanning mechanism is fixed on the detection bed, and the detection probe is detachably arranged on the mechanical scanning mechanism and is used for carrying out automatic scanning under the driving of the mechanical scanning mechanism; an ultrasonic probe and an optical lens are arranged in the detection probe and are respectively used for acquiring a two-dimensional ultrasonic image and an optical image of a patient; the diagnosis device host is internally provided with a gynecological disease diagnosis system for controlling the mechanical scanning mechanism and carrying out image processing and analysis on the acquired ultrasonic images and optical images.
2. The three-dimensional ultrasonic gynecological disease diagnosis device according to claim 1, characterized in that: the mechanical scanning mechanism comprises a translation mechanism and a mechanical arm, the translation mechanism comprises a vertical slide rail, a support plate and a slide block, and the mechanical arm is fixedly connected with the slide block; the two vertical slide rails are respectively fixed on two sides of the detection bed and are parallel to the lying direction of the patient; the supporting plate is parallel to the bed surface of the detection bed and is perpendicular to the vertical sliding rail; two pulleys are respectively arranged on the supporting plate and parallel to two ends of the vertical sliding rail, and the pulleys are embedded into the vertical sliding rail and roll along the vertical sliding rail; two horizontal sliding rails are respectively arranged on the two sides of the supporting plate, which are perpendicular to the vertical sliding rails; the slider is arranged on the supporting plate and is in sliding connection with the horizontal sliding rail.
3. The three-dimensional ultrasonic gynecological disease diagnosis device according to claim 2, characterized in that: the mechanical arm is a six-degree-of-freedom mechanical arm which is fixed on the upper surface of the sliding block, and a clamping mechanism is arranged at the tail end of the six-degree-of-freedom mechanical arm; the clamping mechanism comprises a motor and a clamp, the motor is detachably mounted at the tail end of the six-degree-of-freedom mechanical arm, the driving end of the motor is connected with the clamp, and the clamp is used for clamping the detection probe.
4. The three-dimensional ultrasonic gynecological disease diagnosis device according to claim 3, characterized in that: the detection probe comprises an ultrasonic probe, an optical lens, a light guide optical fiber and a transparent shell; the ultrasonic probe and the optical lens face in the same direction, the light guide optical fiber is coated on the outer surfaces of the ultrasonic probe and the optical lens, and the transparent shell is coated on the outer surface of the light guide optical fiber.
5. The three-dimensional ultrasonic gynecological disease diagnosis device according to claim 4, characterized in that: the gynecological disease diagnosis system comprises an image acquisition module, an image processing module, a disease diagnosis module and an output module which are connected in sequence; the image acquisition module is connected with the detection probe and is used for acquiring image information acquired by the detection probe; the image processing module is used for processing the image acquired by the image acquisition module to acquire corresponding image characteristics; the disease diagnosis module is used for automatically identifying and classifying the image characteristics acquired by the image processing module and obtaining a diagnosis result; the output module is connected with the display screen and used for outputting and displaying the diagnosis result obtained by the disease diagnosis module.
6. The three-dimensional ultrasonic gynecological disease diagnosis device according to claim 5, characterized in that: the gynecological disease diagnosis system also comprises a control module, wherein the control module comprises a main control unit and a scanning control unit; the main control unit is respectively connected with the scanning control unit, the image acquisition module, the image processing module, the disease diagnosis module and the output module and is used for controlling the normal operation of each module or unit; the scanning control unit is in communication connection with the mechanical scanning mechanism and is used for controlling the motion state of the mechanical scanning mechanism.
7. The three-dimensional ultrasonic gynecological disease diagnosis device according to claim 6, characterized in that: the image acquisition module comprises an ultrasonic image acquisition unit, an optical image acquisition unit and a position information matching unit; the ultrasonic image acquisition unit is connected with the ultrasonic probe and is used for acquiring a two-dimensional ultrasonic image; the optical image acquisition unit is connected with the optical lens and is used for acquiring a two-dimensional optical image in the uterine cavity; the position information matching unit is respectively connected with the ultrasonic image acquisition unit, the optical image acquisition unit and the scanning control unit and is used for matching the motion information provided by the scanning control unit with the image information acquired by the ultrasonic image acquisition unit and the optical image acquisition unit, so that the information output by the image acquisition module comprises the image information and the position information.
8. The three-dimensional ultrasonic gynecological disease diagnosis device according to claim 5, characterized in that: the image processing module comprises a preprocessing unit, a three-dimensional reconstruction unit, an image fusion unit and a feature extraction unit which are sequentially connected; the preprocessing unit is used for carrying out filtering and denoising, image enhancement and image scaling processing on the image information input by the image acquisition module; the three-dimensional reconstruction unit is used for converting the preprocessed image information and position information into three-dimensional volume data, reconstructing a three-dimensional image of a uterine cavity, and respectively outputting an ultrasonic image and an optical image of a sagittal plane, a coronal plane and a cross section of the uterus; the image fusion unit is used for fusing the optical image output by the three-dimensional reconstruction unit into a corresponding ultrasonic image to obtain a fused ultrasonic image; the feature extraction unit performs image segmentation and focus feature extraction on the fused ultrasonic image, wherein the focus features comprise morphological features, distribution features, edge features, texture features and echo features.
9. The three-dimensional ultrasonic gynecological disease diagnosis device according to claim 5, characterized in that: the disease diagnosis module comprises a model training unit and a disease classification unit; the model training unit is used for training a neural network model based on focus characteristics of a training sample, and the disease classification unit is used for automatically classifying the focus characteristics output by the image processing module based on the neural network model trained by the model training unit and outputting disease categories; the disease categories include uterine malformations, endometrial polyps, endometrial hyperplasia, uterine fibroids and endometrial cancer, the endometrial hyperplasia categories include simple hyperplasia, compound hyperplasia and atypical hyperplasia, the uterine fibroids categories include submucosal fibroids, intermuscular fibroids and submucosal fibroids.
10. The three-dimensional ultrasonic gynecological disease diagnosis device according to claim 5, characterized in that: the gynecological disease diagnosis system further comprises a storage module, wherein the storage module is connected with the control module and used for storing the acquired image information, the output diagnosis information and the motion path information of the mechanical scanning mechanism.
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Address after: Kunming University of technology, No.68, Wenchang Road, Wuhua District, Kunming City, Yunnan Province Applicant after: Wang Shican Address before: 350004 School of medical technology and engineering, Taijiang campus, Fujian Medical University, No.88 Jiaotong Road, Fuzhou City, Fujian Province Applicant before: Wang Shican |
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Application publication date: 20200724 |
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