CN111436430A - 一种消化内镜消毒液及其制备方法 - Google Patents
一种消化内镜消毒液及其制备方法 Download PDFInfo
- Publication number
- CN111436430A CN111436430A CN202010431018.2A CN202010431018A CN111436430A CN 111436430 A CN111436430 A CN 111436430A CN 202010431018 A CN202010431018 A CN 202010431018A CN 111436430 A CN111436430 A CN 111436430A
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- China
- Prior art keywords
- sodium
- disinfectant
- digestive
- mixed solution
- ether
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 46
- 230000001079 digestive effect Effects 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title abstract description 11
- VVOAZFWZEDHOOU-UHFFFAOYSA-N honokiol Natural products OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 claims abstract description 35
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims abstract description 32
- ZWLUXSQADUDCSB-UHFFFAOYSA-N phthalaldehyde Chemical compound O=CC1=CC=CC=C1C=O ZWLUXSQADUDCSB-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229940054441 o-phthalaldehyde Drugs 0.000 claims abstract description 17
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 32
- 239000011259 mixed solution Substances 0.000 claims description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
- 238000003756 stirring Methods 0.000 claims description 25
- 239000000243 solution Substances 0.000 claims description 21
- 238000010438 heat treatment Methods 0.000 claims description 17
- 230000007797 corrosion Effects 0.000 claims description 14
- 238000005260 corrosion Methods 0.000 claims description 14
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 13
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims description 12
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims description 12
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 11
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 claims description 11
- 235000019982 sodium hexametaphosphate Nutrition 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 10
- JDSQBDGCMUXRBM-UHFFFAOYSA-N 2-[2-(2-butoxypropoxy)propoxy]propan-1-ol Chemical compound CCCCOC(C)COC(C)COC(C)CO JDSQBDGCMUXRBM-UHFFFAOYSA-N 0.000 claims description 9
- 239000006184 cosolvent Substances 0.000 claims description 8
- 239000003112 inhibitor Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 239000003381 stabilizer Substances 0.000 claims description 8
- 239000004094 surface-active agent Substances 0.000 claims description 8
- 230000000249 desinfective effect Effects 0.000 claims description 7
- 235000019830 sodium polyphosphate Nutrition 0.000 claims description 6
- 230000003078 antioxidant effect Effects 0.000 claims description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 239000003963 antioxidant agent Substances 0.000 claims description 4
- 235000006708 antioxidants Nutrition 0.000 claims description 4
- 239000002738 chelating agent Substances 0.000 claims description 4
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 4
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 4
- 235000018417 cysteine Nutrition 0.000 claims description 4
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 4
- 235000019441 ethanol Nutrition 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
- -1 hydroxy diphenyl ether Chemical compound 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 229940057950 sodium laureth sulfate Drugs 0.000 claims description 4
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims description 4
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 claims description 4
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims description 2
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 235000010323 ascorbic acid Nutrition 0.000 claims description 2
- 239000011668 ascorbic acid Substances 0.000 claims description 2
- 229960005070 ascorbic acid Drugs 0.000 claims description 2
- 229910021538 borax Inorganic materials 0.000 claims description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 2
- 239000004327 boric acid Substances 0.000 claims description 2
- 235000010338 boric acid Nutrition 0.000 claims description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- PSLWZOIUBRXAQW-UHFFFAOYSA-M dimethyl(dioctadecyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC PSLWZOIUBRXAQW-UHFFFAOYSA-M 0.000 claims description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 2
- PCAXGMRPPOMODZ-UHFFFAOYSA-N disulfurous acid, diammonium salt Chemical compound [NH4+].[NH4+].[O-]S(=O)S([O-])(=O)=O PCAXGMRPPOMODZ-UHFFFAOYSA-N 0.000 claims description 2
- 238000001839 endoscopy Methods 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 2
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims description 2
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 2
- 229940068041 phytic acid Drugs 0.000 claims description 2
- 235000002949 phytic acid Nutrition 0.000 claims description 2
- 239000000467 phytic acid Substances 0.000 claims description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 2
- MDSQKJDNWUMBQQ-UHFFFAOYSA-M sodium myreth sulfate Chemical compound [Na+].CCCCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O MDSQKJDNWUMBQQ-UHFFFAOYSA-M 0.000 claims description 2
- 229940048086 sodium pyrophosphate Drugs 0.000 claims description 2
- 159000000000 sodium salts Chemical class 0.000 claims description 2
- 235000010265 sodium sulphite Nutrition 0.000 claims description 2
- 239000004328 sodium tetraborate Substances 0.000 claims description 2
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 2
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 claims description 2
- 235000019345 sodium thiosulphate Nutrition 0.000 claims description 2
- 235000019832 sodium triphosphate Nutrition 0.000 claims description 2
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 2
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims 1
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Natural products C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 claims 1
- 229960001484 edetic acid Drugs 0.000 claims 1
- 150000007529 inorganic bases Chemical class 0.000 claims 1
- 150000004760 silicates Chemical class 0.000 claims 1
- 229940083542 sodium Drugs 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract description 38
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 36
- 230000002147 killing effect Effects 0.000 abstract description 10
- 241000894006 Bacteria Species 0.000 abstract description 7
- 244000000010 microbial pathogen Species 0.000 abstract description 6
- 238000002791 soaking Methods 0.000 abstract description 6
- 241000233866 Fungi Species 0.000 abstract description 4
- BYTORXDZJWWIKR-UHFFFAOYSA-N Hinokiol Natural products CC(C)c1cc2CCC3C(C)(CO)C(O)CCC3(C)c2cc1O BYTORXDZJWWIKR-UHFFFAOYSA-N 0.000 abstract description 3
- FVYXIJYOAGAUQK-UHFFFAOYSA-N honokiol Chemical compound C1=C(CC=C)C(O)=CC=C1C1=CC(CC=C)=CC=C1O FVYXIJYOAGAUQK-UHFFFAOYSA-N 0.000 abstract description 3
- 244000005700 microbiome Species 0.000 abstract description 3
- 102000004169 proteins and genes Human genes 0.000 abstract description 3
- 108090000623 proteins and genes Proteins 0.000 abstract description 3
- 230000007246 mechanism Effects 0.000 abstract description 2
- 230000035515 penetration Effects 0.000 abstract description 2
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 25
- 238000012360 testing method Methods 0.000 description 17
- 239000003002 pH adjusting agent Substances 0.000 description 15
- 230000000694 effects Effects 0.000 description 14
- 230000000052 comparative effect Effects 0.000 description 9
- 210000004215 spore Anatomy 0.000 description 9
- 239000004115 Sodium Silicate Substances 0.000 description 8
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 8
- 229910052911 sodium silicate Inorganic materials 0.000 description 8
- 239000000725 suspension Substances 0.000 description 8
- 238000005406 washing Methods 0.000 description 8
- 230000001580 bacterial effect Effects 0.000 description 7
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 7
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 6
- 244000063299 Bacillus subtilis Species 0.000 description 5
- 235000014469 Bacillus subtilis Nutrition 0.000 description 5
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 4
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 229960002233 benzalkonium bromide Drugs 0.000 description 4
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 235000019794 sodium silicate Nutrition 0.000 description 4
- 241000222122 Candida albicans Species 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 229940095731 candida albicans Drugs 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 229910000975 Carbon steel Inorganic materials 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 239000010962 carbon steel Substances 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000009972 noncorrosive effect Effects 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 235000015393 sodium molybdate Nutrition 0.000 description 2
- 239000011684 sodium molybdate Substances 0.000 description 2
- TVXXNOYZHKPKGW-UHFFFAOYSA-N sodium molybdate (anhydrous) Chemical compound [Na+].[Na+].[O-][Mo]([O-])(=O)=O TVXXNOYZHKPKGW-UHFFFAOYSA-N 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 2
- 241000353754 Bacillus subtilis subsp. niger Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 206010064091 Iatrogenic infection Diseases 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- SWLVFNYSXGMGBS-UHFFFAOYSA-N ammonium bromide Chemical compound [NH4+].[Br-] SWLVFNYSXGMGBS-UHFFFAOYSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 210000004666 bacterial spore Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 230000005669 field effect Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- MEFBJEMVZONFCJ-UHFFFAOYSA-N molybdate Chemical compound [O-][Mo]([O-])(=O)=O MEFBJEMVZONFCJ-UHFFFAOYSA-N 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 241000894007 species Species 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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Abstract
本发明涉及一种消化内镜消毒液及其制备方法，其中将邻苯二甲醛、异丙醇、三氯羟基二苯醚与厚朴酚复配，采用不同机制的杀菌消毒成分直接或间接作用于致病微生物的生物蛋白质，增强对致病微生物如真菌、细菌、芽孢等的穿透作用，进而增强所述消毒液对上述微生物的杀灭作用，实现了消化内镜等精密医疗器械的高水平消毒。同时，本发明的消毒液还具有稳定性好，明显缩短所的浸泡时间，对消化内镜等医疗器械的腐蚀性小等优点。
Description
技术领域
本发明涉及一种消化内镜消毒液及其制备方法，属于消毒液领域。
背景技术
消化内镜是一种重复性使用的精密检查器械,是消化领域重要的诊疗手段。但是由于消化内镜价格昂贵，且需要进入人体内部进行检查和治疗，因此，其消毒问题已经成为保障患者健康和预防医源性感染的重要问题之一。
目前，消化内镜的消毒主要为化学药液和气体两种，其中化学药液浸泡是更为常用的消毒方法。化学消毒剂种类繁多，如苯扎溴铵(新洁尔灭)、含氯消毒剂、戊二醛、过氧乙酸等。它们对各类细菌及少数芽孢菌有灭活作用，还能使真菌及病毒灭活，且无腐蚀性。苯扎溴铵对病毒具有杀伤作用，但消毒所需时间较长，否则消毒作用较差，故目前已不提倡使用；含氯消毒剂长期使用可使内镜软管受损，临床也较少用。戊二醛是国内目前较普遍使用的消毒剂，但是其气味大，对人体和环境均有危害，而且浸泡时间长，在临床应用中存在其对医患双方健康损害、出现耐药菌等多种问题。过氧乙酸对消化内镜进行消毒明显提高了消毒速率和效果，但是其仍有刺激性气味。而邻苯二甲醛作为一种高效消毒灭菌剂，具有高效、快速、毒性低、刺激性小等优点，日益受到关注和广泛使用。但是，目前，现有技术中可供选择的邻苯二甲醛产品较少。
发明内容
针对现有技术中存在的不足，本发明提供了一种消化内镜消毒液，所述消毒液具有高水平消毒、、浸泡时间短、刺激性小等特点，对真菌、细菌和芽孢等具有显著的杀灭效果。
为实现本发明，采取的技术方案是一种消化内镜消毒液，按质量百分比计，包括邻苯二甲醛0.5～5％、异丙醇5～10％、三氯羟基二苯醚0.5～2％、厚朴酚1.5～5％、表面活性剂1～10％、助溶剂0.5～10％、缓蚀剂0.2～5％、稳定剂0.2～6％、pH调节剂适量、余量为水。
在一个优选的实施方式中，所述表面活性剂选自脂肪醇聚氧乙烯醚、烷基酚聚氧乙烯、脂肪酸烷醇酰胺、聚氧乙烯聚氧丙烯丙二醇醚、十六烷基三甲基溴化铵、双十八烷基二甲基溴化铵、月桂醇聚醚硫酸钠、肉豆蔻醇聚醚硫酸钠或椰油酰氨基丙基甜菜碱的一种或多种。
在一个优选的实施方式中，所述助溶剂选自乙醇、甘油、丙二醇和聚乙二醇中的一种或多种。
在一个优选的实施方式中，所述缓蚀剂选自硅酸盐、钼酸盐、植酸、季戊四醇、六偏磷酸钠和多聚磷酸钠中的一种或多种。
在一个优选的实施方式中，所述稳定剂可以包括螯合剂和/或抗氧化剂；所述螯合剂选自乙二胺四乙酸及其钠盐、三聚磷酸钠、多聚磷酸钠、六偏磷酸钠、焦磷酸钠、乙二胺四乙酸及其钠中的一种或者几种；所述抗氧化剂选自抗坏血酸、抗坏血酸棕榈酸酯、亚硫酸钠、硫代硫酸钠、焦亚硫酸氨、半胱氨酸中的一种或多种。
在一个优选的实施方式中，所述pH值调节剂为无机强碱、碳酸盐、碳酸氢盐、硼酸、硼砂、磷酸二氢钾和磷酸氢二钠中的一种或多种。
在一个优选的实施方式中，所述消化内镜消毒液的pH值为7.5～8.5。
本发明的另一个目的是提供一种消化内镜消毒液的制备方法，包括以下步骤：
将邻苯二甲醛、异丙醇、缓蚀剂和稳定剂与部分水混合，边加热边搅拌，得到混合液1；
将三氯羟基二苯醚、厚朴酚、表面活性剂、助溶剂和剩余水混合，边加热边搅拌，得到混合液2；
将混合液1和混合液2混合，搅拌均与，加入pH调节剂至pH值为7.5-8.5，得到所述消化内镜消毒液。
有益效果
本发明首次将厚朴酚作为有效成分应用于消化内镜的消毒领域。本发明将邻苯二甲醛、异丙醇、三氯羟基二苯醚与厚朴酚复配，采用不同机制的杀菌消毒成分直接或间接作用于致病微生物的生物蛋白质，增强对致病微生物如真菌、细菌、芽孢等的穿透作用，进而增强所述消毒液对上述微生物的杀灭作用，实现了消化内镜等精密医疗器械的高水平消毒。同时，本发明的消毒液还具有稳定性好，明显缩短所的浸泡时间，对消化内镜等医疗器械的腐蚀性小等优点。
本发明的消毒液中还添加了表面活性剂、助溶剂、缓蚀剂、稳定剂等成分。利用表面活性剂的润湿、促渗透等作用，增加有效成分对致病微生物表面的接触面积，促进有效成分对致病微生物的杀灭作用。助溶剂加快邻苯二甲醛、三氯羟基二苯醚、厚朴酚等成分的溶解和相互融合速度，避免有效成分混合不均匀导致的效果不稳定以及长时间搅拌和加热导致的有效成分损失。加入缓蚀剂则降低了邻苯二甲醛等成分消化内镜的腐蚀性。稳定剂则增强了所述消化液的抗氧化性，保证产品品质稳定。
具体实施方式
还可进一步通过实施例来理解本发明，其中所述实施例说明了一些制备或使用方法。然而，要理解的是，这些实施例不限制本发明。现在已知的或进一步开发的本发明的变化被认为落入本文中描述的和以下要求保护的本发明范围之内。
实施例1
一种消化内镜消毒液，按质量百分比计，包括邻苯二甲醛2.5％、异丙醇6％、三氯羟基二苯醚1％、厚朴酚2.5％、聚氧乙烯聚氧丙烯丙二醇醚5％、丙二醇3％、硅酸钠1％、六偏磷酸钠1.5％，抗坏血酸棕榈酸酯1.5％、pH调节剂适量、余量为水。
所述消化液的制备方法包括以下步骤：
将邻苯二甲醛、异丙醇、硅酸钠、六偏磷酸钠和抗坏血酸棕榈酸酯与部分水混合，边加热边搅拌，得到混合液1；
将三氯羟基二苯醚、厚朴酚、聚氧乙烯聚氧丙烯丙二醇醚、丙二醇和剩余水混合，边加热边搅拌，得到混合液2；
将混合液1和混合液2混合，搅拌均与，加入pH调节剂至pH值为8.5，得到所述消化内镜消毒液。
实施例2
一种消化内镜消毒液，按质量百分比计，包括邻苯二甲醛2％、异丙醇5％、三氯羟基二苯醚1.5％、厚朴酚3％、月桂醇聚醚硫酸钠6％、聚乙二醇2.5％、钼酸钠2％、乙二胺四乙酸钠1.5％，半胱氨酸1.5％、pH调节剂适量、余量为水。
所述消化液的制备方法包括以下步骤：
将邻苯二甲醛、异丙醇、钼酸钠、乙二胺四乙酸钠和半胱氨酸与部分水混合，边加热边搅拌，得到混合液1；
将三氯羟基二苯醚、厚朴酚、月桂醇聚醚硫酸钠、聚乙二醇和剩余水混合，边加热边搅拌，得到混合液2；
将混合液1和混合液2混合，搅拌均与，加入pH调节剂至pH值为8.5，得到所述消化内镜消毒液。
实施例3
一种消化内镜消毒液，按质量百分比计，包括邻苯二甲醛1.5％、异丙醇7％、三氯羟基二苯醚1％、厚朴酚2％、椰油酰氨基丙基甜菜碱8％、甘油5％、多聚磷酸钠2.5％、抗坏血酸棕榈酸酯3％、pH调节剂适量、余量为水。
所述消化液的制备方法包括以下步骤：
将邻苯二甲醛、异丙醇、多聚磷酸钠、抗坏血酸棕榈酸酯与部分水混合，边加热边搅拌，得到混合液1；
将三氯羟基二苯醚、厚朴酚、椰油酰氨基丙基甜菜碱、甘油和剩余水混合，边加热边搅拌，得到混合液2；
将混合液1和混合液2混合，搅拌均与，加入pH调节剂至pH值为8.5，得到所述消化内镜消毒液。
对比例1
一种消化内镜消毒液，按质量百分比计，包括邻苯二甲醛1.5％、异丙醇6％、三氯羟基二苯醚1％、苯扎溴铵2.5％、聚氧乙烯聚氧丙烯丙二醇醚5％、丙二醇3％、硅酸钠1％、六偏磷酸钠1.5％，抗坏血酸棕榈酸酯1.5％、pH调节剂适量、余量为水。
所述消化液的制备方法包括以下步骤：
将邻苯二甲醛、异丙醇、硅酸钠、六偏磷酸钠和抗坏血酸棕榈酸酯与部分水混合，边加热边搅拌，得到混合液1；
将三氯羟基二苯醚、苯扎溴铵、聚氧乙烯聚氧丙烯丙二醇醚、丙二醇和剩余水混合，边加热边搅拌，得到混合液2；
将混合液1和混合液2混合，搅拌均与，加入pH调节剂至pH值为8.5，得到所述消化内镜消毒液。
对比例2：
一种消化内镜消毒液，按质量百分比计，包括邻苯二甲醛1.5％、乙醇6％、三氯羟基二苯醚1％、厚朴酚2.5％、聚氧乙烯聚氧丙烯丙二醇醚5％、丙二醇3％、硅酸钠1％、六偏磷酸钠1.5％，抗坏血酸棕榈酸酯1.5％、pH调节剂适量、余量为水。
所述消化液的制备方法包括以下步骤：
将邻苯二甲醛、乙醇、硅酸钠、六偏磷酸钠和抗坏血酸棕榈酸酯与部分水混合，边加热边搅拌，得到混合液1；
将三氯羟基二苯醚、厚朴酚、聚氧乙烯聚氧丙烯丙二醇醚、丙二醇和剩余水混合，边加热边搅拌，得到混合液2；
将混合液1和混合液2混合，搅拌均与，加入pH调节剂至pH值为8.5，得到所述消化内镜消毒液。
对比例3：
一种消化内镜消毒液，按质量百分比计，包括戊二醛1.5％、异丙醇6％、三氯羟基二苯醚1％、厚朴酚2.5％、聚氧乙烯聚氧丙烯丙二醇醚5％、丙二醇3％、硅酸钠1％、六偏磷酸钠1.5％，抗坏血酸棕榈酸酯1.5％、pH调节剂适量、余量为水。
所述消化液的制备方法包括以下步骤：
将戊二醛、异丙醇、硅酸钠、六偏磷酸钠和抗坏血酸棕榈酸酯与部分水混合，边加热边搅拌，得到混合液1；
将三氯羟基二苯醚、厚朴酚、聚氧乙烯聚氧丙烯丙二醇醚、丙二醇和剩余水混合，边加热边搅拌，得到混合液2；
将混合液1和混合液2混合，搅拌均与，加入pH调节剂至pH值为8.5，得到所述消化内镜消毒液。
试验例1：考察本发明的消毒液的杀菌效果和内镜消毒模拟现场效果。
1.材料
试验指标菌为金黄色葡萄球菌(ATCC 6538)、枯草杆菌黑色变种芽孢(ATCC9372)、大肠杆菌(8099)和白色念珠菌(ATCC 10231)，由中国普通微生物菌种保藏中心提供。
制备菌悬液和染菌载体：取各试验菌种，经增菌培养，取单个典型菌落接种营养琼脂培养基斜面，培养后洗下斜面上菌苔，用稀释液配制成所需浓度菌悬液，备用；依据2002年版《消毒技术规范》培养出枯草杆菌黑色变种芽孢悬，在灭菌的聚四氟乙烯管腔载体，在管腔内污染细菌芽孢，要求回收菌数达到相关规定要求，晾干备用。
2.方法
2.1悬液定量杀菌试验：将本发明的消毒液(实施例1-3)、对比例1-3的消毒液与菌悬液共同放置水浴(20℃)中恒温保持5min。用无菌吸管分别吸取4ml本发明实施例1-3的消毒液和对比例1-3的消毒液注入六个相同的无菌试管中，分别吸取0.5ml菌悬液和0.5ml3％牛血清白蛋白加于上述两个无菌试管中，混合形成均匀的菌药混合液。将菌药混合液相互作用固定时间，吸取0.5ml菌药混合液加于4.5ml中和剂中，混匀。中和作用10min，进行活菌计数，计算杀灭对数值。试验进行3次。
2.2内镜消毒模拟现场试验：按《内镜清洗消毒机消毒效果检验技术规范(试行)》的要求，将实施例1-3和对比例1-3的消毒液装于内镜清洗消毒机的消毒槽内，将模拟内镜体管道在50nm、500nm和950nm处剪开，取染菌载体分别连接在50nm、500nm和950nm处，将模拟内镜体装放于内镜清洗消毒机。按消毒程序(初洗2min、酶洗2min、清洗1min、浸泡消毒5min和末洗2min)进行处理，程序结束后取下载体进行活菌培养计数。试验进行3次。
3.试验结果
3.1悬液定量杀菌效果
试验结果表明，本发明的消毒液对悬液内大肠杆菌、金黄色葡萄球菌和白色念珠菌，分别作用1min和3min，杀灭对数值如下表1所示。对枯草芽胞杆菌黑色变种芽孢作用30min和60min，平均杀灭对数值如下表2所示。本发明实施例1的消毒液对大肠杆菌、金黄色葡萄球菌和白色念珠菌明显优于对比例1。对于枯草芽胞杆菌黑色变种芽孢的作用，本发明实施例1的消毒液仅作用30min即可达到平均杀灭对数值>5的效果，其作用时间相较于对比例1明显缩短。
表1本发明的消毒液对致病细菌的杀灭效果对比
表2本发明的消毒液对枯草芽胞杆菌黑色变种芽孢的杀灭效果对比
3.2内镜消毒模拟现场效果
试验结果表明，本发明的消毒液装于内镜清洗消毒机进行模拟现场消毒，按消毒程序(初洗2min、酶洗2min、清洗1min、浸泡消毒5min、末洗2min)处理后，对载体上人工污染的枯草杆菌黑色变种芽孢的消除效果明显优于对比例1。
表3消化内镜消毒模拟现场试验结果
试验例2：考察本发明的消毒液的稳定性和金属腐蚀性
1.稳定性考察
将密封包装的本发明实施例1的消毒液置37℃恒温恒湿箱中存放90天。于放置前、后分别取样，测定邻苯二甲醛含量，计算其下降率。经计算，邻苯二甲醛含量下降了约1％。
2.金属腐蚀性试验
将不锈钢、铝和碳钢制成直径(20±1)mm、厚1.0mm、中间设置直径15mm小孔的圆片，用砂纸磨去表面氧化层，经洗涤剂浸泡10min，洗净；用无水乙醇再次脱脂。置50℃干燥1h称重后浸泡于本发明实施例1的消毒液中(100ml/片)，浸泡时间为72h，并定期更换消毒液，每日1次。对照组为蒸馏水连续浸泡。浸泡结束后取出金属片，用蒸馏水和软毛刷反复洗净，滤纸吸干，置50℃干燥1h后称重，计算腐蚀速率。经检测，本发明实施例1的消毒液对不锈钢的腐蚀速率为0.0065mm/a，对铝的腐蚀速率是0.0077mm/a，对碳钢的腐蚀速率是0.0051mm/a，均属于基本无腐蚀级别。
基于以上试验结果可以看出，本发明的消毒液配制厚朴酚后对细菌等的杀灭效果明显增强，对芽孢的杀灭时间明显缩短，同时保持了稳定性以及对金属无腐蚀，产生了明显优于现有技术的良好消毒效果。
本发明内容仅仅举例说明了要求保护的一些具体实施方案，其中一个或更多个技术方案中所记载的技术特征可以与任意的一个或多个技术方案相组合，这些经组合而得到的技术方案也在本申请保护范围内，就像这些经组合而得到的技术方案已经在本发明公开内容中具体记载一样。
Claims (8)
1.一种消化内镜消毒液，其特征在于，按质量百分比计，所述消毒液包括邻苯二甲醛0.5～5％、异丙醇5～10％、三氯羟基二苯醚0.5～2％、厚朴酚1.5～5％、表面活性剂1～10％、助溶剂0.5～10％、缓蚀剂0.2～5％、稳定剂0.2～6％、pH调节剂适量、余量为水。
2.根据权利要求1所述的消毒液，其特征在于，所述表面活性剂选自脂肪醇聚氧乙烯醚、烷基酚聚氧乙烯、脂肪酸烷醇酰胺、聚氧乙烯聚氧丙烯丙二醇醚、十六烷基三甲基溴化铵、双十八烷基二甲基溴化铵、月桂醇聚醚硫酸钠、肉豆蔻醇聚醚硫酸钠或椰油酰氨基丙基甜菜碱的一种或多种。
3.根据权利要求1所述的消毒液，其特征在于，所述助溶剂选自乙醇、甘油、丙二醇和聚乙二醇中的一种或多种。
4.根据权利要求1所述的消毒液，其特征在于，所述缓蚀剂选自硅酸盐、钼酸盐、植酸、季戊四醇、六偏磷酸钠和多聚磷酸钠中的一种或多种。
5.根据权利要求1所述的消毒液，其特征在于，所述稳定剂可以包括螯合剂和/或抗氧化剂；所述螯合剂选自乙二胺四乙酸及其钠盐、三聚磷酸钠、多聚磷酸钠、六偏磷酸钠、焦磷酸钠、乙二胺四乙酸及其钠中的一种或者几种；所述抗氧化剂选自抗坏血酸、抗坏血酸棕榈酸酯、亚硫酸钠、硫代硫酸钠、焦亚硫酸氨、半胱氨酸中的一种或多种。
6.根据权利要求1所述的消毒液，其特征在于，所述pH值调节剂为无机强碱、碳酸盐、碳酸氢盐、硼酸、硼砂、磷酸二氢钾和磷酸氢二钠中的一种或多种。
7.根据权利要求1所述的消毒液，其特征在于，所述消化内镜消毒液的pH值为7.5～8.5。
8.根据权利要求1所述的消毒液的制备方法，其特征在于，包括以下步骤：
将邻苯二甲醛、异丙醇、缓蚀剂和稳定剂与部分水混合，边加热边搅拌，得到混合液1；
将三氯羟基二苯醚、厚朴酚、表面活性剂、助溶剂和剩余水混合，边加热边搅拌，得到混合液2；
将混合液1和混合液2混合，搅拌均与，加入pH调节剂至pH值为7.5-8.5，得到所述消化内镜消毒液。
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