CN1113660C - Exterior-applied medicine for treating acne and its preparing process - Google Patents
Exterior-applied medicine for treating acne and its preparing process Download PDFInfo
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- CN1113660C CN1113660C CN00105458A CN00105458A CN1113660C CN 1113660 C CN1113660 C CN 1113660C CN 00105458 A CN00105458 A CN 00105458A CN 00105458 A CN00105458 A CN 00105458A CN 1113660 C CN1113660 C CN 1113660C
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- medicine
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- 239000003814 drug Substances 0.000 title claims abstract description 66
- 206010000496 acne Diseases 0.000 title claims abstract description 41
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 38
- 238000000034 method Methods 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000001816 cooling Methods 0.000 claims abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 31
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 18
- 239000002994 raw material Substances 0.000 claims description 9
- 229940126678 chinese medicines Drugs 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 238000000746 purification Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000003860 topical agent Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 7
- 239000007788 liquid Substances 0.000 abstract description 2
- 238000012545 processing Methods 0.000 abstract description 2
- 241000212948 Cnidium Species 0.000 abstract 2
- 244000241838 Lycium barbarum Species 0.000 abstract 2
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 2
- 235000015468 Lycium chinense Nutrition 0.000 abstract 2
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- 235000012907 honey Nutrition 0.000 abstract 2
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 238000002791 soaking Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 7
- 230000003203 everyday effect Effects 0.000 description 5
- 210000001061 forehead Anatomy 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 238000004321 preservation Methods 0.000 description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 230000002124 endocrine Effects 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
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- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- HPUXDMUGCAWDFW-UHFFFAOYSA-N Osthole Natural products COc1ccc2CCC(=O)Oc2c1C=CC(=O)C HPUXDMUGCAWDFW-UHFFFAOYSA-N 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 206010065954 Stubbornness Diseases 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229960002737 fructose Drugs 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229960001031 glucose Drugs 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- MBRLOUHOWLUMFF-UHFFFAOYSA-N osthole Chemical compound C1=CC(=O)OC2=C(CC=C(C)C)C(OC)=CC=C21 MBRLOUHOWLUMFF-UHFFFAOYSA-N 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to an externally applied medicine and a preparation method thereof for treating acne. The medicine is prepared from three kinds of traditional Chinese medicines which are cnidium fruits, wolfberry bark and honey. The medicine is manufactured into a liquid preparation through reasonably proportioning the cnidium fruits and the wolfberry bark, adding a proper amount of clean water, soaking, twice heating for processing, filtering, cooling and mixing with a proper amount of honey. The medicine has the advantages of few kinds of traditional Chinese medicines, simple preparation process, obvious curative effect, high cure rate and low recurrence rate after cure.
Description
The present invention relates to a kind of external used medicine for the treatment of the acne disease and preparation method thereof, especially utilize external used medicine of the treatment acne disease that Chinese traditional Chinese herbal medicine makes and preparation method thereof.
At present, the acne disease is a kind of dermatosis, also is a kind of commonly encountered diseases, frequently-occurring disease, is commonly called as acne or comedo, and the endocrine disturbance is a pathogenesis etiology.Patient crowd is mainly the adolescent, usually the little red pimple of blackhead appears in forehead and the buccal at face, often improper because of cleaning, cause infection, the patient suffering be can't bear, and relapse rate is quite high, and the acne disease is stubbornness, the hateful disease of the facial appearance of influence, and the topical agent of research and development treatment acne disease has become the concern problem of current the world of medicine.At the field of Chinese medicines, the medicine of existing considerable acne disease, for example, acne ointment certain curative effect and cure rate are arranged, but relapse rate is higher.
The purpose of this invention is to provide a kind of pure Chinese medicinal preparation,, and can overcome the deficiency that has such medicine now preferably with treatment acne pain; Another object of the present invention provides a kind of preparation method of this Chinese medicine preparation.
The objective of the invention is traditional advantage and inner disease outer treat principle by making full use of Chinese herbal medicine, with three flavor Chinese medicine Fructus Cnidiis, Cortex Lycii and Mel rational proportion and suitable processing realize.
The external used medicine of treatment acne disease of the present invention, this medicine are the medicaments of being made by listed weight portion proportioning by following raw material:
Fructus Cnidii 3-25 Cortex Lycii 3-30 Mel 3-20.
The external used medicine of treatment acne disease of the present invention, this medicine are the medicaments of being made by listed preferred weight portion proportioning by following raw material:
Fructus Cnidii 5-20 Cortex Lycii 5-25 Mel 5-12.
The external used medicine of treatment acne disease of the present invention, this medicine are the medicaments of being made by the weight portion proportioning of listed the best by following raw material:
Fructus Cnidii 20 Cortex Lycii 18 Mel 8.
The topical agent that the external used medicine of treatment acne disease of the present invention, described medicament are in the pharmaceutics to be admitted.
As the further improvement of the external used medicine of treatment acne disease of the present invention, described medicament is a water preparation.
The preparation method of the external used medicine of treatment acne disease of the present invention comprises following process steps:
1. Fructus Cnidii and Cortex Lycii are pressed described weight portion proportioning, add 120-1150 kilogram water purification, soaked 1-2 hour;
2. under 90-100 ℃, heated 1-1.5 hour;
3. leach juice with 50 orders-80 mesh sieve, as juice A;
4. will sieve the warm water 90-850 kilogram that surplus two kinds of Chinese medicines add 50-80 ℃, soak 3-10 minute;
5. under 90-100 ℃, heated 0.5-1 hour;
6. leach juice with 50 orders-80 mesh sieve, and mix with juice A;
7. will mix the juice cooling;
8. by described weight portion proportioning Mel is added and mix juice, stir;
9. 30 milliliters every bottle is a fractional pack.
The external used medicine of treatment acne disease of the present invention, wherein the effect of various Chinese medicines and ingredient are listed below:
Cortex Lycii is nontoxic, and removing heat from blood is brought down a fever, and contains sweet alkali soap glycoside, and Bacillus typhi, dysentery bacterium are had stronger inhibitory action, prolongs the effect of medicament preservation term in medicine of the present invention in addition.
The little poison of Fructus Cnidii, removing dampness and killing parasites contains the volatility osthole, is used for the treatment of skin ulcer rash scabies more and itches and skin pruritus, and fungus, influenza virus are had inhibitory action.
Mel is nontoxic, detoxifcation, skin moistening, detumescence, tonifying the stomach and spleen, the equal scalable endocrine of oral administration and externally, contain fructose, glucose, pantothenic acid, nicotinic acid, be rich in vitamin A, D, E, to dysentery bacterium, pyococcus has stronger inhibitory action, be beneficial to the convergence and the healing of skin wound, in medicine of the present invention, also work to prolong the medicament preservation term.
The advantage of the external used medicine of treatment acne disease of the present invention is: this medicine is a pure Chinese medicinal preparation, is used for the facial affected part of patient outward, and nontoxic substantially, side effect are safe in utilization, convenient; Used raw material of Chinese medicine kind is fewer, and preparation method is comparatively simple; The patient that the state of an illness is lighter, continuous use 5-12 day, 30 milliliters of external one fractional packs are smeared the affected part every day and can be cured for 1-3 time; The patient that the state of an illness is heavier, continuous use 15-24 day, an external 2-3 fractional pack, the 60-90 milliliter is smeared the affected part every day and can be cured for 2-5 time; This medicine evident in efficacy, cure rate is higher, and recurrence rate after healing is low, and through the statistics of 50 cases, effective percentage is 100%, and cure rate is 95%; Under the room temperature, the preservation term of this medicine is 1 year.
Below in conjunction with embodiment,, be described further external used medicine of treatment acne disease of the present invention and preparation method thereof.
The external used medicine of the treatment acne disease of present embodiment, make medicament by following raw material by listed optimum weight (kilogram) proportioning:
Fructus Cnidii 20 Cortex Lycii 18 Mel 8.
The external used medicine of the treatment acne disease of present embodiment, described medicament is a water preparation.
The exterior-applied liquid medicine agent medicine of the treatment acne disease of present embodiment, its preparation method comprises following process steps:
1. Fructus Cnidii and Cortex Lycii are pressed described weight proportion, add 800 kilograms of water purification, soaked 1-2 hour;
2. under 90-100 ℃, heated 1-1.5 hour;
3. leach juice with 50 orders-80 mesh sieve, as juice A;
4. will sieve 600 kilograms in the warm water that surplus two kinds of Chinese medicines add 50-80 ℃, soak 3-10 minute;
5. under 90-100 ℃, heated 0.5-1 hour;
6. leach juice with 50 orders-80 mesh sieve, and mix with juice A;
7. will mix the juice cooling;
8. by described weight proportion Mel is added and mix juice, stir;
9. 30 milliliters every bottle is a fractional pack.
Provide several cases of the external used medicine embodiment of treatment acne disease of the present invention below:
Case 1 Feng Kai man birth people from Tianjin in 1981
Suffered from acne sick nearly 2 years, the state of an illness is heavier, and two cheeks are full of acne, and oral medicine and external medicine were all used, and did not see and put.In August, 1999, use 30 milliliters of medicaments of the present invention, i.e. fractional pack, external every day 3 times was cured in 10 days, so far recurrence.
The outstanding woman of case 2 Liu Gui birth people from Beian City, Heilongjiang Province in 1964
Suffered from acne sick nearly 7 years, the state of an illness is heavier, and two cheeks and forehead are full of acne, and oral medicine and external medicine were all used, and the thousands of units of treatment cost do not take effect.In JIUYUE, 1998 is used 50 milliliters of medicaments of the present invention, does not promptly use up two fractional packs, smears every day 3 times, cures in 15 days, so far not recurrence.
Auspicious China woman of 3 weeks of case birth people from Nanjing, Jiangsu Province in 1974
Suffered from acne sick nearly 4 years, the state of an illness is heavier, and two cheeks and forehead are full of acne, and oral medicine and external medicine were all used, and did not take effect.In October, 1998, use 90 milliliters of medicaments of the present invention, i.e. three fractional packs, external every day 3 times was cured in 24 days, so far recurrence.
The characteristics of external used medicine of the treatment acne disease of present embodiment and preparation method thereof are:
The reasonable mixture ratio of three kinds of raw material of Chinese medicine, evident in efficacy, recurrence rate after healing is low, and preparation technology is fairly simple.
Claims (6)
1. external used medicine for the treatment of the acne disease is characterized in that this medicine is the medicament of being made by listed weight portion proportioning by following raw material:
Fructus Cnidii 3-25 Cortex Lycii 3-30 Mel 3-20.
2. the external used medicine of treatment acne disease according to claim 1, wherein the weight portion proportioning of each raw material is:
Fructus Cnidii 5-25 Cortex Lycii 5-20 Mel 5-12.
3. the external used medicine of treatment acne disease according to claim 1, wherein the weight portion proportioning of each raw material is:
Fructus Cnidii 20 Cortex Lycii 18 Mel 8.
4. according to the external used medicine of the described treatment acne of claim 1,2 or 3 disease, it is characterized in that the topical agent that described medicament is in the pharmaceutics to be admitted.
5. the external used medicine of treatment acne disease according to claim 4 is characterized in that described medicament is a water preparation.
6. the external used medicine of treatment acne disease according to claim 5 is characterized in that its preparation method, comprises following process steps:
1. Fructus Cnidii and Cortex Lycii are pressed described weight portion proportioning, add 120-1150 kilogram water purification, soaked 1-2 hour;
2. under 90-100 ℃, heated 1-1.5 hour;
3. leach juice with 50 orders-80 mesh sieve, as juice A;
4. will sieve the warm water 90-850 kilogram that surplus two kinds of Chinese medicines add 50-80 ℃, soak 3-10 minute;
5. under 90-100 ℃, heated 0.5-1 hour;
6. leach juice with 50 orders-80 mesh sieve, and mix with juice A;
7. will mix the juice cooling;
8. by described weight portion proportioning Mel is added and mix juice, stir
9. 30 milliliters every bottle is a fractional pack.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00105458A CN1113660C (en) | 2000-04-06 | 2000-04-06 | Exterior-applied medicine for treating acne and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00105458A CN1113660C (en) | 2000-04-06 | 2000-04-06 | Exterior-applied medicine for treating acne and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1316252A CN1316252A (en) | 2001-10-10 |
| CN1113660C true CN1113660C (en) | 2003-07-09 |
Family
ID=4577714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00105458A Expired - Fee Related CN1113660C (en) | 2000-04-06 | 2000-04-06 | Exterior-applied medicine for treating acne and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1113660C (en) |
-
2000
- 2000-04-06 CN CN00105458A patent/CN1113660C/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN1316252A (en) | 2001-10-10 |
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