CN111358762A - Astaxanthin microcapsule embedding process - Google Patents
Astaxanthin microcapsule embedding process Download PDFInfo
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- CN111358762A CN111358762A CN202010266014.3A CN202010266014A CN111358762A CN 111358762 A CN111358762 A CN 111358762A CN 202010266014 A CN202010266014 A CN 202010266014A CN 111358762 A CN111358762 A CN 111358762A
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- astaxanthin
- oil
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- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 title claims abstract description 47
- 235000013793 astaxanthin Nutrition 0.000 title claims abstract description 47
- 239000001168 astaxanthin Substances 0.000 title claims abstract description 47
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 title claims abstract description 47
- 229940022405 astaxanthin Drugs 0.000 title claims abstract description 47
- 239000003094 microcapsule Substances 0.000 title claims abstract description 29
- 238000000034 method Methods 0.000 title claims abstract description 19
- 230000008569 process Effects 0.000 title claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000000463 material Substances 0.000 claims abstract description 18
- 239000004094 surface-active agent Substances 0.000 claims abstract description 13
- 239000000843 powder Substances 0.000 claims abstract description 12
- 238000001035 drying Methods 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 8
- 230000009471 action Effects 0.000 claims abstract description 6
- 230000001804 emulsifying effect Effects 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims abstract description 6
- 230000010355 oscillation Effects 0.000 claims abstract description 6
- 238000010008 shearing Methods 0.000 claims abstract description 6
- 238000001514 detection method Methods 0.000 claims abstract description 3
- 238000005507 spraying Methods 0.000 claims abstract description 3
- 239000012071 phase Substances 0.000 claims description 45
- 229920000858 Cyclodextrin Polymers 0.000 claims description 5
- 239000001116 FEMA 4028 Substances 0.000 claims description 5
- 229920000881 Modified starch Polymers 0.000 claims description 5
- 239000004368 Modified starch Substances 0.000 claims description 5
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 5
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 5
- 229960004853 betadex Drugs 0.000 claims description 5
- 238000004945 emulsification Methods 0.000 claims description 5
- 235000019426 modified starch Nutrition 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- FYGDTMLNYKFZSV-DZOUCCHMSA-N alpha-D-Glcp-(1->4)-alpha-D-Glcp-(1->4)-D-Glcp Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)O[C@H](O[C@@H]2[C@H](OC(O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-DZOUCCHMSA-N 0.000 claims description 4
- 239000008346 aqueous phase Substances 0.000 claims description 4
- 239000002270 dispersing agent Substances 0.000 claims 1
- 238000005516 engineering process Methods 0.000 abstract description 6
- 238000009210 therapy by ultrasound Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 description 6
- 238000012986 modification Methods 0.000 description 6
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- 230000006872 improvement Effects 0.000 description 3
- 229930003427 Vitamin E Natural products 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to an astaxanthin microcapsule embedding process, which comprises the following operation steps: s1, selecting water phase wall materials and oil phase contents; s2, mixing: mixing according to the proportion; s3, high-pressure ultrasonic treatment, homogenizing and emulsifying: the mixture is subjected to high-speed shearing, high-speed convection impact and high-frequency oscillation in a high-pressure ultrasonic homogenizing cavity, and the astaxanthin oil enables molecular bonds of a water phase and an oil phase to be tightly combined to form uniform mixed liquid drops under the action of a surfactant; s4, embedding, granulating and drying: forming water-phase cavity bubbles among the mixed droplets, and instantly drying by spraying to form oil-in-water O/W astaxanthin microcapsule powder; s5, carrying out material receiving detection in the clean area; and S6, subpackaging and warehousing. The astaxanthin microcapsule embedding technology and the process greatly improve the water solubility, improve the bioavailability and obviously improve the embedding rate of the astaxanthin microcapsule powder.
Description
Technical Field
The invention relates to the technical field of embedding processes, in particular to an astaxanthin microcapsule embedding process.
Background
Astaxanthin is a natural, nontoxic, bright-colored carotenoid with high biological activity, the oxidation resistance of the astaxanthin is 10 times that of β -carotene and 500 times that of vitamin E, and is called super vitamin E.
The astaxanthin microcapsule powder produced by the astaxanthin microcapsule embedding technology in the prior art is poor in water solubility, not easy to absorb and low in bioavailability, and meanwhile, the astaxanthin microcapsule powder produced by the astaxanthin microcapsule embedding technology is low in embedding rate, easy to be oxidized and decomposed when meeting air and illumination and short in quality guarantee period, so that the problems are urgently solved.
Disclosure of Invention
The invention aims to solve the technical problem of overcoming the defects of the prior art and provides an astaxanthin microcapsule embedding process.
In order to solve the technical problems, the technical scheme provided by the invention is as follows: an astaxanthin microencapsulation process, which comprises the following operation steps:
selection of S1, aqueous phase wall material and oil phase content: selecting a proper water phase wall material, selecting a surfactant in an oil phase content, and selecting heat-sensitive, easily-oxidized or easily-volatilized astaxanthin oil;
s2, mixing: mixing according to the proportion;
s3, high-pressure ultrasonic homogenizing and emulsifying: the mixture is subjected to high-speed shearing, high-speed convection impact and high-frequency oscillation in a high-pressure ultrasonic homogenizing cavity, and the astaxanthin oil enables molecular bonds of a water phase and an oil phase to be tightly combined to form uniform mixed liquid drops under the action of a surfactant;
s4, embedding, granulating and drying: forming water-phase cavity bubbles among the mixed droplets, and instantly drying by spraying to form oil-in-water O/W astaxanthin microcapsule powder;
s5, carrying out material receiving detection in the clean area;
and S6, finishing packaging.
In the step S1, the aqueous phase wall material is one or more of β cyclodextrin, maltooligosaccharide and modified starch.
As a modification, the oil phase content in step S1 includes astaxanthin oil and a surfactant.
As an improvement, the ratio in the step S2 is the ratio of the water phase to the oil phase: 1: 0.2-0.4.
As a modification, the high-pressure ultrasonic homogeneous emulsification in the step S3 adopts 25000 and 35000PSi as pressure and 50-60kHz as frequency.
As a modification, the microencapsulation embedding temperature in the step S4 is controlled at an instantaneous temperature of 160-200 ℃.
As a modification, the particle size of the astaxanthin microcapsule powder formed in the step S4 is 50-60 microns.
The invention has the following advantages:
1. the astaxanthin microcapsule embedding technology and process greatly improve water solubility and bioavailability.
2. The embedding rate of the astaxanthin microcapsule powder produced by the astaxanthin microcapsule embedding technology and technology is obviously improved, and the quality guarantee period is prolonged from 3-6 months to 24 months.
Detailed Description
The present invention will be described in further detail with reference to examples.
Example 1
In the specific implementation of the invention, the operation steps of the astaxanthin microcapsule embedding process comprise:
s1, selecting a water phase wall material and an oil phase content, wherein the water phase wall material is a combination of β cyclodextrin, malto-oligosaccharide and modified starch, and the oil phase content comprises astaxanthin oil and a surfactant;
s2, mixing: according to the proportion, the proportion of the water phase and the oil phase is as follows: 1: 0.4, mixing;
s3, high-pressure ultrasonic homogenizing and emulsifying: the mixture is subjected to high-speed shearing, high-speed convection impact and high-frequency oscillation through a high-pressure ultrasonic homogenizing cavity, wherein the pressure adopted by high-pressure ultrasonic homogenizing emulsification is 35000PSi, the frequency is 60kHz, and under the action of a surfactant, astaxanthin oil enables molecular bonds of a water phase and an oil phase to be tightly combined to form uniform mixed liquid drops;
s4, embedding, granulating and drying: forming water-phase cavity bubbles among the mixed droplets, and spray-drying instantly to form oil-in-water O/W astaxanthin microcapsule powder with particle diameter of 60 microns and microcapsule embedding temperature controlled at 200 deg.C instantly.
Example 2
In the specific implementation of the invention, the operation steps of the astaxanthin microcapsule embedding process comprise:
s1, selecting a water phase wall material and an oil phase content, wherein the water phase wall material is a combination of β cyclodextrin and modified starch, and the oil phase content comprises astaxanthin oil and a surfactant;
s2, mixing: according to the proportion, the proportion of the water phase and the oil phase is as follows: 1: 0.2, mixing;
s3, high-pressure ultrasonic homogenizing and emulsifying: the mixture is subjected to high-speed shearing, high-speed convection impact and high-frequency oscillation through a high-pressure ultrasonic homogenizing cavity, the high-pressure ultrasonic homogenizing emulsification adopts 25000PSi and 50kHz of pressure, and astaxanthin oil is subjected to tight combination of water phase and oil phase molecular bonds under the action of a surfactant to form uniform mixed liquid drops;
s4, embedding, granulating and drying: forming water-phase cavity bubbles among the mixed droplets, and spray-instantly drying to form oil-in-water O/W astaxanthin microcapsule powder with particle diameter of 50 μm and microcapsule embedding temperature controlled at 160 deg.C.
Example 3
In the specific implementation of the invention, the operation steps of the astaxanthin microcapsule embedding process comprise:
s1, selecting a water phase wall material and an oil phase content, wherein the water phase wall material is one or more of β cyclodextrin, malto-oligosaccharide and modified starch, and the oil phase content comprises astaxanthin oil and a surfactant;
s2, mixing: according to the proportion, the proportion of the water phase and the oil phase is as follows: 1: 0.33, mixing;
s3, high-pressure ultrasonic homogenizing and emulsifying: the mixture is subjected to high-speed shearing, high-speed convection impact and high-frequency oscillation through a high-pressure ultrasonic homogenizing cavity, the pressure adopted by high-pressure ultrasonic homogenizing emulsification is 30000PSi, the frequency is 55kHz, and under the action of a surfactant, astaxanthin oil enables molecular bonds of a water phase and an oil phase to be tightly combined to form uniform mixed liquid drops;
s4, embedding, granulating and drying: forming water-phase cavity bubbles among the mixed droplets, and spray-drying instantly to form oil-in-water O/W astaxanthin microcapsule powder with particle diameter of 50-60 μm and microcapsule embedding temperature controlled at instant temperature of 180 deg.C.
Although the invention has been described in detail hereinabove with respect to a general description and specific embodiments thereof, it will be apparent to those skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (7)
1. An astaxanthin microcapsule embedding process is characterized by comprising the following operation steps:
selection of S1, aqueous phase wall material and oil phase content: selecting a proper water phase wall material, selecting a surfactant in an oil phase content, and selecting heat-sensitive, easily-oxidized or easily-volatilized astaxanthin oil;
s2, mixing: mixing according to the material proportion;
s3, high-pressure ultrasonic homogenizing and emulsifying: the mixture is subjected to high-speed shearing, high-speed convection impact and high-frequency oscillation in a high-pressure ultrasonic homogenizing cavity, and the astaxanthin oil enables molecular bonds of a water phase and an oil phase to be tightly combined to form uniform mixed liquid drops under the action of a surfactant;
s4, embedding, granulating and drying: forming water-phase cavity bubbles among the mixed droplets, and instantly drying by spraying to form oil-in-water O/W astaxanthin microcapsule powder;
s5, carrying out material receiving detection in the clean area;
and S6, adding a dispersing agent, mixing, subpackaging and warehousing.
2. The process of claim 1, wherein the aqueous phase wall material of step S1 is selected from β cyclodextrin, maltooligosaccharide, and modified starch.
3. The process for microencapsulating astaxanthin according to claim 1, wherein: the oil phase content in step S1 includes astaxanthin oil and a surfactant.
4. The process for microencapsulating astaxanthin according to claim 1, wherein: the mixture ratio in the step S2 is the mixture ratio of water phase and oil phase materials: 1: 0.2-0.4.
5. The process for microencapsulating astaxanthin according to claim 1, wherein: the high-pressure ultrasonic homogeneous emulsification in the step S3 adopts 25000-35000PSi as pressure and 50-60kHz as frequency.
6. The process for microencapsulating astaxanthin according to claim 1, wherein: the microencapsulation embedding temperature in the step S4 is controlled to be 160-200 ℃ at the instant temperature.
7. The process for microencapsulating astaxanthin according to claim 1, wherein: the particle size of the astaxanthin microcapsule powder formed in the step S4 is 50-60 microns.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010266014.3A CN111358762A (en) | 2020-04-07 | 2020-04-07 | Astaxanthin microcapsule embedding process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010266014.3A CN111358762A (en) | 2020-04-07 | 2020-04-07 | Astaxanthin microcapsule embedding process |
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| Publication Number | Publication Date |
|---|---|
| CN111358762A true CN111358762A (en) | 2020-07-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010266014.3A Pending CN111358762A (en) | 2020-04-07 | 2020-04-07 | Astaxanthin microcapsule embedding process |
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| CN (1) | CN111358762A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110279805A (en) * | 2019-06-06 | 2019-09-27 | 中国热带农业科学院香料饮料研究所 | A kind of preparation method of vanilla medicinal extract inclusion compound and inclusion compound obtained |
| CN112998270A (en) * | 2021-04-12 | 2021-06-22 | 海南三元星生物科技股份有限公司 | Preparation method of astaxanthin microcapsules |
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| DE102009038565A1 (en) * | 2009-08-22 | 2011-02-24 | Gavrilovic, Rade | Spray container with a valve in a spray head, useful as a mouth spray e.g. for preventing prostate cancer and cystitis, comprises a composition comprising astaxanthin in a microencapsulated form |
| CN104705654A (en) * | 2015-04-02 | 2015-06-17 | 徐权汉 | Preparation method for astaxanthin microcapsules |
| CN105581364A (en) * | 2016-03-07 | 2016-05-18 | 云南瑞升烟草技术（集团）有限公司 | Preparation method of astaxanthin microcapsule and application to cigarette shreds |
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| CN106579312A (en) * | 2016-12-08 | 2017-04-26 | 佛山科学技术学院 | Astaxanthin-adding shrimp paste and preparation method thereof |
-
2020
- 2020-04-07 CN CN202010266014.3A patent/CN111358762A/en active Pending
Patent Citations (5)
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| DE102009038565A1 (en) * | 2009-08-22 | 2011-02-24 | Gavrilovic, Rade | Spray container with a valve in a spray head, useful as a mouth spray e.g. for preventing prostate cancer and cystitis, comprises a composition comprising astaxanthin in a microencapsulated form |
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| CN112998270A (en) * | 2021-04-12 | 2021-06-22 | 海南三元星生物科技股份有限公司 | Preparation method of astaxanthin microcapsules |
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Application publication date: 20200703 |