CN111249335A - Preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces - Google Patents
Preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces Download PDFInfo
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- CN111249335A CN111249335A CN201911287219.3A CN201911287219A CN111249335A CN 111249335 A CN111249335 A CN 111249335A CN 201911287219 A CN201911287219 A CN 201911287219A CN 111249335 A CN111249335 A CN 111249335A
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- angelica dahurica
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- wall
- radix angelicae
- salvia miltiorrhiza
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- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 238000002791 soaking Methods 0.000 claims abstract description 45
- 241000304195 Salvia miltiorrhiza Species 0.000 claims abstract description 36
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims abstract description 36
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000008367 deionised water Substances 0.000 claims abstract description 27
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 27
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 18
- 241000218378 Magnolia Species 0.000 claims abstract description 17
- 235000006679 Mentha X verticillata Nutrition 0.000 claims abstract description 17
- 235000002899 Mentha suaveolens Nutrition 0.000 claims abstract description 17
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims abstract description 17
- 241001506766 Xanthium Species 0.000 claims abstract description 17
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 15
- 150000001875 compounds Chemical class 0.000 claims abstract description 15
- 239000010949 copper Substances 0.000 claims abstract description 15
- 229910052802 copper Inorganic materials 0.000 claims abstract description 15
- 238000001035 drying Methods 0.000 claims abstract description 15
- 230000001954 sterilising effect Effects 0.000 claims abstract description 13
- 238000005303 weighing Methods 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 238000004140 cleaning Methods 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims abstract description 7
- 238000004806 packaging method and process Methods 0.000 claims abstract description 7
- 241000213006 Angelica dahurica Species 0.000 claims description 87
- 239000000203 mixture Substances 0.000 claims description 26
- 239000000843 powder Substances 0.000 claims description 24
- 238000010298 pulverizing process Methods 0.000 claims description 20
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 18
- 239000008187 granular material Substances 0.000 claims description 18
- 230000005684 electric field Effects 0.000 claims description 12
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 12
- 239000007779 soft material Substances 0.000 claims description 12
- 238000010025 steaming Methods 0.000 claims description 12
- 239000000284 extract Substances 0.000 claims description 7
- 241000005787 Cistanche Species 0.000 claims description 6
- 241000628997 Flos Species 0.000 claims description 6
- 235000006886 Zingiber officinale Nutrition 0.000 claims description 6
- 238000009835 boiling Methods 0.000 claims description 6
- 239000009670 cang er zi wan Substances 0.000 claims description 6
- 235000008397 ginger Nutrition 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 238000007873 sieving Methods 0.000 claims description 6
- 238000005507 spraying Methods 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 239000000080 wetting agent Substances 0.000 claims description 6
- 238000000227 grinding Methods 0.000 claims description 4
- 241000125175 Angelica Species 0.000 claims description 3
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 3
- 244000273928 Zingiber officinale Species 0.000 claims 1
- 208000002193 Pain Diseases 0.000 abstract description 6
- 206010019233 Headaches Diseases 0.000 abstract description 4
- 231100000869 headache Toxicity 0.000 abstract description 4
- 229910000906 Bronze Inorganic materials 0.000 abstract description 2
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 239000010974 bronze Substances 0.000 abstract description 2
- KUNSUQLRTQLHQQ-UHFFFAOYSA-N copper tin Chemical compound [Cu].[Sn] KUNSUQLRTQLHQQ-UHFFFAOYSA-N 0.000 abstract description 2
- 230000003821 menstrual periods Effects 0.000 abstract description 2
- 238000010411 cooking Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 7
- 241000234314 Zingiber Species 0.000 description 5
- 238000007605 air drying Methods 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 208000028659 discharge Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces, which comprises the following steps: weighing quantitatively, cleaning the main material, slicing, frying, cooking, drying, crushing, granulating, sterilizing, packaging and storing; the invention also discloses radix angelicae and salvia miltiorrhiza wall-broken decoction pieces, and the formula of the radix angelicae and salvia miltiorrhiza wall-broken decoction pieces comprises the following components: 20-25% of radix angelicae, 10-14% of salvia miltiorrhiza, 5-9% of copper, 1-4% of notopterygium root, 3-6% of cocklebur fruit, 2-5% of magnolia flower, 3-7% of mint, 8-12% of soaking agent, 9-13% of impregnating compound and the balance of deionized water; the beneficial effects are that: the formula adopted by the invention is the raw materials specified by the national standard, the wall-broken radix angelicae and radix salviae miltiorrhizae decoction pieces prepared by the invention are greatly improved, and the blood-activating and pain-relieving performance of the decoction pieces is improved by adding the radix salviae miltiorrhizae, so that the decoction pieces are more practical and can be eaten by women in menstrual period; the addition of the cocklebur fruit, the magnolia flower, the mint, the bronze and the notopterygium root improves the headache treatment performance of the decoction pieces.
Description
Technical Field
The invention relates to the technical field of preparation of radix angelicae decoction pieces, and particularly relates to a preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces.
Background
Radix angelicae, the name of traditional Chinese medicine, is a perennial big herb with a height of 1-2.5 meters, a cylindrical root with a diameter of 2-5 cm at the base of the stem, a basal leaf with a pinnate division, a multiple umbrella-shaped inflorescence with a terminal growth or lateral growth, and a long-round fruit with an oval shape. The main varieties include radix Angelicae Dahuricae, radix Angelicae Dahuricae (original variety), and radix Angelicae Pubescentis; the root is used as a medicine, and has the functions of dispelling diseases, removing dampness, expelling pus, promoting granulation, promoting blood circulation, relieving pain and the like; can be used for treating wind-cold type common cold, headache, rhinitis, and toothache. Can also be used as perfume for treating leucorrhea with red and white discharge, pain, furuncle, and toxic swelling; some northern provinces are cultivated, so that the production is self-selling, and the adjustment is omitted for a small number of provinces; generally under the forest, at the forest edge, beside the stream, in the shrubs and on the mountain and valley grasslands;
in the prior art, with the popularization of a medicine wall breaking technology, radix angelicae wall breaking decoction pieces are used for treating symptoms of activating blood and relieving pain in the market, but for menstrual women, the traditional radix angelicae wall breaking piece is poor in blood activating performance, so that the articles produced by the radix angelicae wall breaking decoction pieces cannot adapt to various crowds.
Disclosure of Invention
The invention aims to provide a preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces, which aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: a preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces comprises the following steps:
s1: quantitative weighing, namely weighing all the raw materials according to the components;
s2: cleaning the main materials, namely soaking the angelica dahurica and the salvia miltiorrhiza in clear water for 20-40 min, then soaking in 0.5% acetic acid solution for 1-2 h, taking out, and naturally drying;
s3: slicing and frying, namely slicing the angelica dahurica and the salvia miltiorrhiza which are dried in the step two, controlling the thickness of the slices to be 0.2cm, frying by adopting slow fire for 6-10 min until the surfaces of the slices after frying are not obviously changed in color and texture, and paying attention to that the angelica dahurica and the salvia miltiorrhiza are respectively and independently fried;
s4: steaming and drying, namely putting the fried angelica dahurica slices into a soaking agent while the fried angelica dahurica slices are hot, adding deionized water until the mixed liquid just submerges the angelica dahurica slices, steaming and boiling the angelica dahurica slices for 2 to 4 hours under pressure, taking out the angelica dahurica slices after the juice is completely absorbed, taking out the angelica dahurica slices, airing the angelica dahurica slices until the angelica dahurica slices are dried from four to six times, putting the angelica dahurica slices into a high-voltage electric field dryer again, treating the angelica dahurica slices for 2 hours at 55 ℃ with the electric field strength of 360kV/m, taking out the angelica dahurica slices, spraying a wetting agent on the surfaces of the angelica dahurica slices to keep the surfaces of the angelica;
s5: pulverizing radix Angelicae Dahuricae, Saviae Miltiorrhizae radix, herba cistanches, Notopterygii rhizoma, fructus Xanthii, flos Magnoliae and herba Menthae, sequentially adding into a wall breaking machine, breaking wall, pulverizing, sieving, and coarse powder of 105 mesh; then placing the prepared coarse powder into an ultrafine grinder, grinding for 20-35 min at 15 ℃, and grinding to 400 meshes to obtain ultrafine powder;
s6: granulating and sterilizing, namely preparing the ultrafine powder obtained in the step five into a soft material by using deionized water, putting the prepared soft material into a rotary granulator to obtain mixture granules, and putting the mixture granules into an ultraviolet sterilizer for sterilization and drying;
and S7, packaging and storing, subpackaging the mixture granules obtained in the step six under the aseptic condition to obtain the finished product, and storing in a ventilated and dry place.
The formula of the radix angelicae and salvia miltiorrhiza wall-broken decoction pieces comprises the following components: 20-25% of angelica dahurica, 10-14% of salvia miltiorrhiza, 5-9% of copper, 1-4% of notopterygium root, 3-6% of cocklebur fruit, 2-5% of magnolia flower, 3-7% of mint, 8-12% of soaking agent, 9-13% of impregnating compound and the balance of deionized water.
Preferably, the traditional Chinese medicine composition comprises 20% of angelica dahurica, 14% of salvia miltiorrhiza, 5% of copper, 4% of notopterygium root, 3% of cocklebur fruit, 5% of magnolia flower, 3% of mint, 8% of soaking agent, 9% of impregnating compound and the balance of deionized water.
Preferably, the traditional Chinese medicine composition comprises 25% of angelica dahurica, 10% of salvia miltiorrhiza, 9% of copper kidney, 1% of notopterygium root, 6% of cocklebur fruit, 2% of magnolia flower, 7% of mint, 12% of soaking agent, 13% of impregnating compound and the balance of deionized water.
Preferably, the traditional Chinese medicine composition comprises 22% of angelica dahurica, 12% of salvia miltiorrhiza, 7% of copper kidney, 2% of notopterygium root, 4% of cocklebur fruit, 3% of magnolia flower, 4% of mint, 9% of soaking agent, 10% of impregnating compound and the balance of deionized water.
Preferably, the traditional Chinese medicine composition comprises 23% of angelica dahurica, 13% of salvia miltiorrhiza, 8% of copper kidney, 3% of notopterygium root, 5% of cocklebur fruit, 4% of magnolia flower, 5% of mint, 11% of soaking agent, 11% of impregnating compound and the balance of deionized water.
Preferably, the soaking agent is ginger juice, and the soaking agent is yellow wine or dark plum extract or a mixture of the yellow wine and the dark plum extract.
Compared with the prior art, the invention has the beneficial effects that: the formula adopted by the invention is the raw materials specified by the national standard, the wall-broken radix angelicae and radix salviae miltiorrhizae decoction pieces prepared by the invention are greatly improved, and the blood-activating and pain-relieving performance of the decoction pieces is improved by adding the radix salviae miltiorrhizae, so that the decoction pieces are more practical and can be eaten by women in menstrual period; the addition of the cocklebur fruit, the magnolia flower, the mint, the bronze and the notopterygium root improves the headache treatment performance of the decoction pieces.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example one
The invention provides a technical scheme that: a preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces comprises the following steps:
s1: quantitative weighing, namely weighing all the raw materials according to the components;
s2: cleaning the main materials, soaking radix Angelicae Dahuricae and Saviae Miltiorrhizae radix in clear water for 20min, soaking in 0.5% acetic acid solution for 1 hr, taking out, and naturally air drying;
s3: slicing and frying, namely slicing the angelica dahurica and the salvia miltiorrhiza which are dried in the step two, controlling the thickness of the slices to be 0.2cm, frying by adopting slow fire for 6min until no obvious color and texture change exists on the surfaces of the slices after frying, and paying attention to that the angelica dahurica and the salvia miltiorrhiza are respectively and independently fried;
s4: steaming and drying, namely putting the fried angelica dahurica slices into a soaking agent while the fried angelica dahurica slices are hot, adding deionized water until the mixed liquid just submerges the angelica dahurica slices, steaming and boiling for 2h under pressure, taking out after the juice is absorbed completely, taking out, airing to be dried from four to six times, putting into a high-voltage electric field dryer again, treating for 2h at 55 ℃, taking out, spraying a wetting agent on the surface of the angelica dahurica slices to keep the surface of the angelica dahurica slices in a wet state, standing for 15min, putting into the high-voltage electric field dryer, and treating for 2h at 65 ℃;
s5: pulverizing radix Angelicae Dahuricae, Saviae Miltiorrhizae radix, herba cistanches, Notopterygii rhizoma, fructus Xanthii, flos Magnoliae and herba Menthae, sequentially adding into a wall breaking machine, breaking wall, pulverizing, sieving, and coarse powder of 105 mesh; then placing the obtained coarse powder into an ultrafine pulverizer, pulverizing for 20min at 15 ℃, and pulverizing to 400 meshes to obtain ultrafine powder;
s6: granulating and sterilizing, namely preparing the ultrafine powder obtained in the step five into a soft material by using deionized water, putting the prepared soft material into a rotary granulator to obtain mixture granules, and putting the mixture granules into an ultraviolet sterilizer for sterilization and drying;
and S7, packaging and storing, subpackaging the mixture granules obtained in the step six under the aseptic condition to obtain the finished product, and storing in a ventilated and dry place.
The formula of the radix angelicae and salvia miltiorrhiza wall-broken decoction pieces comprises the following components: 20% of angelica dahurica, 14% of salvia miltiorrhiza, 5% of copper, 4% of notopterygium root, 3% of cocklebur fruit, 5% of biond magnolia flower, 3% of mint, 8% of soaking agent, 9% of impregnating compound and the balance of deionized water.
Wherein the soaking agent is ginger juice, and the soaking agent is yellow wine.
Example two
The invention provides a technical scheme that: a preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces comprises the following steps:
s1: quantitative weighing, namely weighing all the raw materials according to the components;
s2: cleaning the main materials, soaking radix Angelicae Dahuricae and Saviae Miltiorrhizae radix in clear water for 25min, soaking in 0.5% acetic acid solution for 1.2 hr, taking out, and naturally air drying;
s3: slicing and frying, namely slicing the angelica dahurica and the salvia miltiorrhiza which are dried in the step two, controlling the thickness of the slices to be 0.2cm, frying by adopting slow fire for 7min until no obvious color and texture change exists on the surfaces of the slices after frying, and paying attention to that the angelica dahurica and the salvia miltiorrhiza are respectively and independently fried;
s4: steaming and drying, namely putting the fried angelica dahurica slices into a soaking agent while the fried angelica dahurica slices are hot, adding deionized water until the mixed liquid just submerges the angelica dahurica slices, steaming and boiling the angelica dahurica slices for 2.4 hours under pressure, taking out the angelica dahurica slices after the juice is completely absorbed, taking out the angelica dahurica slices, airing the angelica dahurica slices until the angelica dahurica slices are dried from four to six times, putting the angelica dahurica slices into a high-voltage electric field dryer again, treating the angelica dahurica slices for 2 hours at 55 ℃ with the electric field strength of 360kV/m, taking out the angelica dahurica slices, spraying a wetting agent on the surfaces of the angelica dahurica slices to keep the surfaces of the angelica;
s5: pulverizing radix Angelicae Dahuricae, Saviae Miltiorrhizae radix, herba cistanches, Notopterygii rhizoma, fructus Xanthii, flos Magnoliae and herba Menthae, sequentially adding into a wall breaking machine, breaking wall, pulverizing, sieving, and coarse powder of 105 mesh; then placing the obtained coarse powder in an ultrafine pulverizer, pulverizing for 25min at 15 deg.C, and pulverizing to 400 mesh to obtain ultrafine powder;
s6: granulating and sterilizing, namely preparing the ultrafine powder obtained in the step five into a soft material by using deionized water, putting the prepared soft material into a rotary granulator to obtain mixture granules, and putting the mixture granules into an ultraviolet sterilizer for sterilization and drying;
and S7, packaging and storing, subpackaging the mixture granules obtained in the step six under the aseptic condition to obtain the finished product, and storing in a ventilated and dry place.
The formula of the radix angelicae and salvia miltiorrhiza wall-broken decoction pieces comprises the following components: 25% of angelica dahurica, 10% of salvia miltiorrhiza, 9% of copper, 1% of notopterygium root, 6% of cocklebur fruit, 2% of biond magnolia flower, 7% of mint, 12% of soaking agent, 13% of impregnating compound and the balance of deionized water.
Wherein the soaking agent is ginger juice, and the soaking agent is dark plum extract.
EXAMPLE III
The invention provides a technical scheme that: a preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces comprises the following steps:
s1: quantitative weighing, namely weighing all the raw materials according to the components;
s2: cleaning the main materials, soaking radix Angelicae Dahuricae and Saviae Miltiorrhizae radix in clear water for 30min, soaking in 0.5% acetic acid solution for 1.5 hr, taking out, and naturally air drying;
s3: slicing and frying, namely slicing the angelica dahurica and the salvia miltiorrhiza which are dried in the step two, controlling the thickness of the slices to be 0.2cm, frying by adopting slow fire for 8min until no obvious color and texture change exists on the surfaces of the slices after frying, and paying attention to that the angelica dahurica and the salvia miltiorrhiza are respectively and independently fried;
s4: steaming and drying, namely putting the fried angelica dahurica slices into a soaking agent while the fried angelica dahurica slices are hot, adding deionized water until the mixed liquid just submerges the angelica dahurica slices, steaming and boiling the angelica dahurica slices for 3.4 hours under pressure, taking out the angelica dahurica slices after the juice is completely absorbed, taking out the angelica dahurica slices, airing the angelica dahurica slices until the angelica dahurica slices are dried from four to six times, putting the angelica dahurica slices into a high-voltage electric field dryer again, treating the angelica dahurica slices for 2 hours at 55 ℃ with the electric field strength of 360kV/m, taking out the angelica dahurica slices, spraying a wetting agent on the surfaces of the angelica dahurica slices to keep the surfaces in a wet;
s5: pulverizing radix Angelicae Dahuricae, Saviae Miltiorrhizae radix, herba cistanches, Notopterygii rhizoma, fructus Xanthii, flos Magnoliae and herba Menthae, sequentially adding into a wall breaking machine, breaking wall, pulverizing, sieving, and coarse powder of 105 mesh; then placing the obtained coarse powder into an ultrafine pulverizer, pulverizing for 29min at 15 ℃, and pulverizing to 400 meshes to obtain ultrafine powder;
s6: granulating and sterilizing, namely preparing the ultrafine powder obtained in the step five into a soft material by using deionized water, putting the prepared soft material into a rotary granulator to obtain mixture granules, and putting the mixture granules into an ultraviolet sterilizer for sterilization and drying;
and S7, packaging and storing, subpackaging the mixture granules obtained in the step six under the aseptic condition to obtain the finished product, and storing in a ventilated and dry place.
The formula of the radix angelicae and salvia miltiorrhiza wall-broken decoction pieces comprises the following components: 22% of angelica dahurica, 12% of salvia miltiorrhiza, 7% of copper, 2% of notopterygium root, 4% of cocklebur fruit, 3% of biond magnolia flower, 4% of mint, 9% of soaking agent, 10% of impregnating compound and the balance of deionized water.
Wherein the soaking agent is ginger juice, and the soaking agent is a mixture of yellow wine and dark plum extract.
Example four
The invention provides a technical scheme that: a preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces comprises the following steps:
s1: quantitative weighing, namely weighing all the raw materials according to the components;
s2: cleaning the main materials, soaking radix Angelicae Dahuricae and Saviae Miltiorrhizae radix in clear water for 40min, soaking in 0.5% acetic acid solution for 2 hr, taking out, and naturally air drying;
s3: slicing and frying, namely slicing the angelica dahurica and the salvia miltiorrhiza which are dried in the step two, controlling the thickness of the slices to be 0.2cm, frying by adopting slow fire for 10min until no obvious color and texture change exists on the surfaces of the slices after frying, and paying attention to that the angelica dahurica and the salvia miltiorrhiza are respectively and independently fried;
s4: steaming and drying, namely putting the fried angelica dahurica slices into a soaking agent while the fried angelica dahurica slices are hot, adding deionized water until the mixed liquid just submerges the angelica dahurica slices, steaming and boiling for 4h under pressure, taking out after the juice is absorbed completely, taking out, airing to be dried from four to six times, putting into a high-voltage electric field dryer again, treating for 2h at 55 ℃, taking out, spraying a wetting agent on the surface of the angelica dahurica slices to keep the surface of the angelica dahurica slices in a wet state, standing for 15min, putting into the high-voltage electric field dryer, and treating for 2h at 65 ℃;
s5: pulverizing radix Angelicae Dahuricae, Saviae Miltiorrhizae radix, herba cistanches, Notopterygii rhizoma, fructus Xanthii, flos Magnoliae and herba Menthae, sequentially adding into a wall breaking machine, breaking wall, pulverizing, sieving, and coarse powder of 105 mesh; then placing the obtained coarse powder into an ultrafine pulverizer, pulverizing for 35min at 15 ℃, and pulverizing to 400 meshes to obtain ultrafine powder;
s6: granulating and sterilizing, namely preparing the ultrafine powder obtained in the step five into a soft material by using deionized water, putting the prepared soft material into a rotary granulator to obtain mixture granules, and putting the mixture granules into an ultraviolet sterilizer for sterilization and drying;
and S7, packaging and storing, subpackaging the mixture granules obtained in the step six under the aseptic condition to obtain the finished product, and storing in a ventilated and dry place.
The formula of the radix angelicae and salvia miltiorrhiza wall-broken decoction pieces comprises the following components: 23% of angelica dahurica, 13% of salvia miltiorrhiza, 8% of copper, 3% of notopterygium root, 5% of cocklebur fruit, 4% of biond magnolia flower, 5% of mint, 11% of soaking agent, 11% of impregnating compound and the balance of deionized water.
Wherein the soaking agent is ginger juice, and the soaking agent is a mixture of yellow wine and dark plum extract.
By carrying out component detection on the four groups of embodiments and selecting a group of angelica dahurica decoction pieces from the market for comparison, the detection results are as follows:
the experimental data in the table show that the fourth group of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces have the best effects of promoting blood circulation, relieving pain and treating headache, so that the method has better popularization value.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. A preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces is characterized by comprising the following steps of: the preparation method comprises the following steps:
s1: quantitative weighing, namely weighing all the raw materials according to the components;
s2: cleaning the main materials, namely soaking the angelica dahurica and the salvia miltiorrhiza in clear water for 20-40 min, then soaking in 0.5% acetic acid solution for 1-2 h, taking out, and naturally drying;
s3: slicing and frying, namely slicing the angelica dahurica and the salvia miltiorrhiza which are dried in the step two, controlling the thickness of the slices to be 0.2cm, frying by adopting slow fire for 6-10 min until the surfaces of the slices after frying are not obviously changed in color and texture, and paying attention to that the angelica dahurica and the salvia miltiorrhiza are respectively and independently fried;
s4: steaming and drying, namely putting the fried angelica dahurica slices into a soaking agent while the fried angelica dahurica slices are hot, adding deionized water until the mixed liquid just submerges the angelica dahurica slices, steaming and boiling the angelica dahurica slices for 2 to 4 hours under pressure, taking out the angelica dahurica slices after the juice is completely absorbed, taking out the angelica dahurica slices, airing the angelica dahurica slices until the angelica dahurica slices are dried from four to six times, putting the angelica dahurica slices into a high-voltage electric field dryer again, treating the angelica dahurica slices for 2 hours at 55 ℃ with the electric field strength of 360kV/m, taking out the angelica dahurica slices, spraying a wetting agent on the surfaces of the angelica dahurica slices to keep the surfaces of the angelica;
s5: pulverizing radix Angelicae Dahuricae, Saviae Miltiorrhizae radix, herba cistanches, Notopterygii rhizoma, fructus Xanthii, flos Magnoliae and herba Menthae, sequentially adding into a wall breaking machine, breaking wall, pulverizing, sieving, and coarse powder of 105 mesh; then placing the prepared coarse powder into an ultrafine grinder, grinding for 20-35 min at 15 ℃, and grinding to 400 meshes to obtain ultrafine powder;
s6: granulating and sterilizing, namely preparing the ultrafine powder obtained in the step five into a soft material by using deionized water, putting the prepared soft material into a rotary granulator to obtain mixture granules, and putting the mixture granules into an ultraviolet sterilizer for sterilization and drying;
and S7, packaging and storing, subpackaging the mixture granules obtained in the step six under the aseptic condition to obtain the finished product, and storing in a ventilated and dry place.
2. The radix angelicae and radix salviae miltiorrhizae wall-broken decoction piece as claimed in claim 1, which is characterized in that; the formula of the B comprises the following components: 20-25% of angelica dahurica, 10-14% of salvia miltiorrhiza, 5-9% of copper, 1-4% of notopterygium root, 3-6% of cocklebur fruit, 2-5% of magnolia flower, 3-7% of mint, 8-12% of soaking agent, 9-13% of impregnating compound and the balance of deionized water.
3. The radix angelicae and radix salviae miltiorrhizae wall-broken decoction piece as claimed in claim 2, which is characterized in that: comprises 20% of angelica dahurica, 14% of salvia miltiorrhiza, 5% of copper, 4% of notopterygium root, 3% of cocklebur fruit, 5% of biond magnolia flower, 3% of mint, 8% of soaking agent, 9% of impregnating compound and the balance of deionized water.
4. The radix angelicae and radix salviae miltiorrhizae wall-broken decoction piece as claimed in claim 2, which is characterized in that: comprises 25% of angelica dahurica, 10% of salvia miltiorrhiza, 9% of copper, 1% of notopterygium root, 6% of cocklebur fruit, 2% of biond magnolia flower, 7% of mint, 12% of soaking agent, 13% of impregnating compound and the balance of deionized water.
5. The radix angelicae and radix salviae miltiorrhizae wall-broken decoction piece as claimed in claim 2, which is characterized in that: comprises 22% of angelica dahurica, 12% of salvia miltiorrhiza, 7% of copper, 2% of notopterygium root, 4% of cocklebur fruit, 3% of biond magnolia flower, 4% of mint, 9% of soaking agent, 10% of impregnating compound and the balance of deionized water.
6. The radix angelicae and radix salviae miltiorrhizae wall-broken decoction piece as claimed in claim 2, which is characterized in that: comprises 23% of angelica dahurica, 13% of salvia miltiorrhiza, 8% of copper, 3% of notopterygium root, 5% of cocklebur fruit, 4% of biond magnolia flower, 5% of mint, 11% of soaking agent, 11% of impregnating compound and the balance of deionized water.
7. The radix angelicae and radix salviae miltiorrhizae wall-broken decoction piece as claimed in claim 2, which is characterized in that: the soaking agent is ginger juice, and the soaking agent is yellow wine or dark plum extract or a mixture of the yellow wine and the dark plum extract.
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| US6413554B1 (en) * | 2000-11-14 | 2002-07-02 | Yong Il No | Compositions for treatment of hyperlipidemia and angina pectoris |
| CN104306415A (en) * | 2014-09-24 | 2015-01-28 | 苏州市天灵中药饮片有限公司 | Preparation method of radix angelicae wall-broken decoction pieces |
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| US6413554B1 (en) * | 2000-11-14 | 2002-07-02 | Yong Il No | Compositions for treatment of hyperlipidemia and angina pectoris |
| CN104306415A (en) * | 2014-09-24 | 2015-01-28 | 苏州市天灵中药饮片有限公司 | Preparation method of radix angelicae wall-broken decoction pieces |
| CN107823232A (en) * | 2017-10-26 | 2018-03-23 | 安徽协和成药业饮片有限公司 | A kind of preparation method of angelica dahurica decoction pieces |
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