CN111012705A - Extraction process of kapok leaf extract and essence cream thereof - Google Patents
Extraction process of kapok leaf extract and essence cream thereof Download PDFInfo
- Publication number
- CN111012705A CN111012705A CN201911308035.0A CN201911308035A CN111012705A CN 111012705 A CN111012705 A CN 111012705A CN 201911308035 A CN201911308035 A CN 201911308035A CN 111012705 A CN111012705 A CN 111012705A
- Authority
- CN
- China
- Prior art keywords
- kapok
- polydimethylsiloxane
- essence
- extract
- extraction process
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000284 extract Substances 0.000 title claims abstract description 98
- 244000146553 Ceiba pentandra Species 0.000 title claims abstract description 89
- 235000003301 Ceiba pentandra Nutrition 0.000 title claims abstract description 87
- 238000000605 extraction Methods 0.000 title claims abstract description 42
- 239000006071 cream Substances 0.000 title claims abstract description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 61
- 238000003756 stirring Methods 0.000 claims abstract description 38
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 30
- 238000002386 leaching Methods 0.000 claims abstract description 25
- 239000008367 deionised water Substances 0.000 claims abstract description 14
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 14
- 239000000706 filtrate Substances 0.000 claims abstract description 14
- 238000011049 filling Methods 0.000 claims abstract description 8
- 238000001914 filtration Methods 0.000 claims abstract description 8
- 238000007873 sieving Methods 0.000 claims abstract description 5
- 238000002791 soaking Methods 0.000 claims abstract description 5
- 238000005406 washing Methods 0.000 claims abstract description 5
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 76
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 76
- 239000000203 mixture Substances 0.000 claims description 42
- -1 polydimethylsiloxane Polymers 0.000 claims description 37
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 36
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 32
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 24
- 102000008186 Collagen Human genes 0.000 claims description 19
- 108010035532 Collagen Proteins 0.000 claims description 19
- 102000016942 Elastin Human genes 0.000 claims description 19
- 108010014258 Elastin Proteins 0.000 claims description 19
- 229920001436 collagen Polymers 0.000 claims description 19
- 229920006037 cross link polymer Polymers 0.000 claims description 19
- 229920002549 elastin Polymers 0.000 claims description 19
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 17
- BYUQATUKPXLFLZ-UIOOFZCWSA-N CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(O)=O)CC1=CN=CN1 Chemical compound CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(O)=O)CC1=CN=CN1 BYUQATUKPXLFLZ-UIOOFZCWSA-N 0.000 claims description 15
- 229940093441 palmitoyl oligopeptide Drugs 0.000 claims description 15
- 241000257465 Echinoidea Species 0.000 claims description 14
- 235000011187 glycerol Nutrition 0.000 claims description 14
- 230000001965 increasing effect Effects 0.000 claims description 14
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 13
- 235000007689 Borago officinalis Nutrition 0.000 claims description 13
- 240000004282 Grewia occidentalis Species 0.000 claims description 13
- 229960005323 phenoxyethanol Drugs 0.000 claims description 13
- 229920002554 vinyl polymer Polymers 0.000 claims description 13
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 12
- 239000011780 sodium chloride Substances 0.000 claims description 12
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 12
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 12
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims description 11
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 11
- IUMSDRXLFWAGNT-UHFFFAOYSA-N Dodecamethylcyclohexasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 IUMSDRXLFWAGNT-UHFFFAOYSA-N 0.000 claims description 11
- OQILCOQZDHPEAZ-UHFFFAOYSA-N Palmitinsaeure-octylester Natural products CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 claims description 11
- 239000003995 emulsifying agent Substances 0.000 claims description 11
- GJQLBGWSDGMZKM-UHFFFAOYSA-N ethylhexyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(CC)CCCCC GJQLBGWSDGMZKM-UHFFFAOYSA-N 0.000 claims description 11
- 229940100524 ethylhexylglycerin Drugs 0.000 claims description 11
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 11
- 229940042585 tocopherol acetate Drugs 0.000 claims description 10
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 9
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 9
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 9
- IHRKJQSLKLYWBQ-QKDODKLFSA-N (2s)-2-[[(2s)-1-[(2s)-5-amino-2-[[2-(hexadecanoylamino)acetyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O IHRKJQSLKLYWBQ-QKDODKLFSA-N 0.000 claims description 6
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 6
- DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 claims description 6
- 229940094946 palmitoyl tetrapeptide-7 Drugs 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- 239000003906 humectant Substances 0.000 claims description 5
- 239000009636 Huang Qi Substances 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000003755 preservative agent Substances 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
- 229940051250 hexylene glycol Drugs 0.000 claims description 3
- 238000005070 sampling Methods 0.000 claims description 3
- 230000002528 anti-freeze Effects 0.000 claims description 2
- 239000007798 antifreeze agent Substances 0.000 claims description 2
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims 1
- 230000003712 anti-aging effect Effects 0.000 abstract description 11
- 238000001556 precipitation Methods 0.000 abstract description 8
- 238000007605 air drying Methods 0.000 abstract 1
- 238000010298 pulverizing process Methods 0.000 abstract 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 61
- 239000000523 sample Substances 0.000 description 49
- 229940008099 dimethicone Drugs 0.000 description 41
- 230000000694 effects Effects 0.000 description 21
- 210000003491 skin Anatomy 0.000 description 21
- 241000045403 Astragalus propinquus Species 0.000 description 19
- 150000001413 amino acids Chemical class 0.000 description 19
- 235000006533 astragalus Nutrition 0.000 description 19
- 150000004676 glycans Chemical class 0.000 description 17
- 229920001282 polysaccharide Polymers 0.000 description 17
- 239000005017 polysaccharide Substances 0.000 description 17
- 229930182470 glycoside Natural products 0.000 description 16
- 150000002338 glycosides Chemical class 0.000 description 16
- 210000004027 cell Anatomy 0.000 description 14
- 239000003921 oil Substances 0.000 description 12
- 238000012360 testing method Methods 0.000 description 12
- 238000006243 chemical reaction Methods 0.000 description 11
- 230000001153 anti-wrinkle effect Effects 0.000 description 10
- 239000000047 product Substances 0.000 description 10
- 230000032683 aging Effects 0.000 description 8
- 210000002421 cell wall Anatomy 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 7
- 230000009286 beneficial effect Effects 0.000 description 7
- 230000001804 emulsifying effect Effects 0.000 description 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- 239000012535 impurity Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000008569 process Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 230000037303 wrinkles Effects 0.000 description 5
- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 description 4
- 102000004414 Calcitonin Gene-Related Peptide Human genes 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 230000004224 protection Effects 0.000 description 4
- 210000004927 skin cell Anatomy 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 238000010998 test method Methods 0.000 description 4
- 244000293889 Bombax malabaricum Species 0.000 description 3
- 235000004480 Bombax malabaricum Nutrition 0.000 description 3
- 239000004471 Glycine Substances 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 3
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 3
- 208000026935 allergic disease Diseases 0.000 description 3
- 230000007815 allergy Effects 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- VEVRNHHLCPGNDU-MUGJNUQGSA-O desmosine Chemical compound OC(=O)[C@@H](N)CCCC[N+]1=CC(CC[C@H](N)C(O)=O)=C(CCC[C@H](N)C(O)=O)C(CC[C@H](N)C(O)=O)=C1 VEVRNHHLCPGNDU-MUGJNUQGSA-O 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000007803 itching Effects 0.000 description 3
- 230000004089 microcirculation Effects 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 230000003266 anti-allergic effect Effects 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 229920005573 silicon-containing polymer Polymers 0.000 description 2
- 230000037394 skin elasticity Effects 0.000 description 2
- 231100000430 skin reaction Toxicity 0.000 description 2
- 230000037339 smooth wrinkles Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 230000009469 supplementation Effects 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 240000007185 Albizia julibrissin Species 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 240000001432 Calendula officinalis Species 0.000 description 1
- 235000005881 Calendula officinalis Nutrition 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 108010049047 Echinocandins Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 241000305492 Gastrodia Species 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000005016 Intestinal Neoplasms Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 244000215777 Plumeria rubra Species 0.000 description 1
- 235000013087 Plumeria rubra Nutrition 0.000 description 1
- 241001180876 Saposhnikovia Species 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000006750 UV protection Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 229940097275 indigo Drugs 0.000 description 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 201000002313 intestinal cancer Diseases 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 1
- 238000007427 paired t-test Methods 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000009781 safety test method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 230000036555 skin type Effects 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an extraction process of a kapok leaf extract and essence cream thereof. The extraction process comprises washing kapok leaves with deionized water, air drying, pulverizing, and sieving with 20 mesh sieve; adding the crushed kapok leaves, butanediol and deionized water into a container, soaking at normal temperature for 72-75h, and stirring once every 5-15h to obtain a leaching matter; storing the extract at 3-5 deg.C for 48-50h, and filtering to obtain filtrate; and (3) filling the filtrate into a clean container, and standing at normal temperature for later use. The extraction process is simple and feasible to operate, and the kapok leaf extract extracted by the extraction process is stable in quality and not prone to precipitation, turbidity and the like. The essence cream disclosed by the invention is moist and water-replenishing, does not stick greasy, has a good anti-aging effect, and is not easy to deteriorate.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to an extraction process of a kapok leaf extract and essence cream thereof.
Background
Kapok (Bombax malabaricum DC) also known as British tree, Morgan, red jasmine, kapok tree, red cotton, Panzhihua, Bangmang tree and the like is a kapok plant belonging to the genus kapok, a deciduous tree, often blossoming before and after leaves, and is a very spectacular plant which is common in the south of China. Kapok is mostly used as a medicine with flowers, barks and roots, has the effects of dispelling wind, removing dampness, promoting blood circulation, relieving swelling, eliminating stagnation, relieving pain and the like, is one of common medicines of Hainan Li nationality, is mainly decocted with roots, barks, flowers or leaves of the kapok in water for oral administration, and is used for treating red and white dysentery, damp-heat dysentery, female endogenous wind in the month, lung cancer, intestinal cancer, stomachache, hematochezia after defecation, arthralgia and the like.
The kapok leaf is the leaf of the plant kapok. In recent years, kapok has attracted much attention because of its excellent activity in anti-inflammatory, anti-tumor, liver protection, etc., but there are few studies on kapok leaves, and only a few reports on its chemical components and pharmacological actions are reported.
Secondly, there is a report in the prior art that kapok extract is applied to cosmetics. However, the common bombax ceiba extract in the prior art is prepared by boiling bombax ceiba in water, concentrating, drying, and adding excipient such as starch, etc., the extract has complex components, and if a large amount of the extract is added into the skin care product, the skin care product has the problems of irritation, discoloration or precipitation, etc.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention has the following objects: the extraction process of the kapok leaf extract is simple and easy to operate, and the kapok leaf extract extracted by the extraction process is stable in quality and not prone to precipitation, turbidity and the like.
One of the purposes of the invention is realized by adopting the following technical scheme:
an extraction process of a kapok leaf extract is characterized by comprising the following steps: comprises the following steps of (a) carrying out,
(1) washing the kapok leaves with deionized water, drying, crushing, and sieving with a 20-mesh sieve;
(2) adding the crushed kapok leaves, butanediol and deionized water into a container, soaking at normal temperature for 72-75h, and stirring once every 5-15h to obtain a leaching matter;
(3) placing the extract obtained in the step (2) in an environment of 3-5 ℃ for 48-50h, and filtering to obtain filtrate;
(4) and (4) filling the filtrate obtained in the step (3) into a clean container, and placing the container at normal temperature for later use.
In this embodiment, the principle of the kapok leaf extract extraction is as follows: firstly, water/butanediol diffuses to the cell wall of cells through capillaries inside kapok leaves; secondly, water/butanediol passes through the cell wall into the interior of the cell; then, the water/butanediol dissolves hydrophilic polysaccharide, glycoside, amino acid and other components in the cell to form a solution, and the water/butanediol continuously diffuses into the cell due to the concentration difference of the solution inside and outside the cell wall until the cell wall is burst by water/butanediol molecules; furthermore, molecules of components such as polysaccharide, glycoside and amino acid in the kapok leaves diffuse to the interface of the kapok leaves and water/butanediol; and finally, further diffusing the components such as polysaccharide, glycoside and amino acid in the kapok leaves into a water/butanediol system from the interface of the kapok leaves and water/butanediol.
The "crushing" step in the extraction process has a significant effect on the two stages of penetration and diffusion in the kapok leaf extraction process. If the crushing is fine, the fat-soluble oil ester is likely to be leached; on the contrary, if the powder is not crushed or not crushed to be fine enough, the speed of water/butanediol entering cells and the speed of leaching and diffusing components such as polysaccharide, glycoside and amino acid are slow, which is not beneficial to the extraction process.
The extraction process does not need to be carried out under heating conditions, because components such as polysaccharides, glycosides, amino acids, etc. can be dissolved in water at normal temperature, and only the leaching speed is slow. However, if the heat leaching is carried out, the leaching amount of the ineffective impurities is greatly increased, thereby increasing the risk of the subsequent use of the extract.
According to long-term accumulated practical experience, the general leaching time period needs 72-75 h. If the leaching time is too short, the components such as polysaccharide, glycoside and amino acid cannot be fully leached; conversely, when the leaching is carried out to reach saturation, too long a time has no practical significance. And secondly, in the leaching process, the components such as polysaccharide, glycosides and amino acid are continuously stirred, so that the components can be favorably diffused to a solvent, and the extraction effect can be favorably improved.
And finally, storing the extract at 3-5 ℃ for 48-50h, which is beneficial to full precipitation of weak-polarity components, and then filtering to obtain filtrate. When the filtrate is returned to normal temperature, the extract is stable, and quality problems such as precipitation, turbidity and the like are not easy to occur.
As a further example, 1-2 parts of kapok leaves, 4-5 parts of butanediol and 3-5 parts of deionized water are taken in the step (2).
In the embodiment, the using amount of the butanediol is 4-5 parts, so that the system is favorably preserved, the using risk of subsequent extracts is reduced, and the leaching of ineffective impurities is also reduced.
As a further example, 1 part of the kapok leaves, 4 parts of the butanediol and 5 parts of the deionized water are taken in the step (2).
The second purpose of the invention is: the essence cream containing the kapok leaf extract is moisturizing, non-sticky, good in anti-aging effect and not prone to deterioration.
The second purpose of the invention is realized by adopting the following technical scheme:
an essence cream comprising: the component A, the component B, the component C and the component D; wherein,
the component A comprises an emulsifier, ethylhexyl palmitate, cyclopentadimethylsiloxane, polydimethylsiloxane, cyclopentadimethylsiloxane/polydimethylsiloxane/vinyl polydimethylsiloxane crosspolymer and tocopherol acetate;
the component B comprises a humectant, an antifreeze, a preservative and water;
the C component comprises palmitoyl tripeptide-1/palmitoyl tetrapeptide-7, folium gossypii extract, sea urchin collagen, cod elastin, star flower extract and Astragalus membranaceus root extract; the kapok leaf extract is extracted by adopting the extraction process of the kapok leaf extract in any one of the embodiments;
the component D comprises essence.
The essence cream in the embodiment solves the aging problem from all aspects:
(1) enhancing cell activity, improving skin microcirculation: palmitoyl tripeptide-1/palmitoyl tetrapeptide-7 is a segment of less than 10 amino acid sequences, is a hydrolysate of skin matrix before healing after skin injury, and can enhance skin cell activity; palmitoyl tripeptide-1 can promote the synthesis of cell collagen and polysaccharide; the skin cytokine IL6 participates in chronic inflammatory reaction, plays an important role in the skin aging process, and the use of palmitoyl tetrapeptide-7 can reduce the level of IL6 in aging, so that the aim of maintaining the balance of the skin cytokine is fulfilled to realize the skin care and improve microcirculation;
(2) antioxidation: the kapok leaf extract contains components such as polysaccharide, glycosides and amino acid, can eliminate the peroxide free radicals, and has the effects of resisting oxidation and aging;
(3) and (3) collagen supplementation: CGRP (calcitonin gene-related peptide) inhibits immune responses to external and internal stimuli, and as aging (neuroaging) gradually diminishes, supplementation and promotion of CGRP expression may delay aging. Sea urchin collagen (NEUROCOL Y) can promote CGRP expression and maintain skin cell elasticity; sea urchin collagen restores cell activity by promoting endogenous metabolism; sea urchin collagen improves skin elasticity and restores skin youth by promoting collagen synthesis;
(4) and (3) supplementing elastin: elastin is a protein present in the extracellular matrix ECM and is responsible for flexibility and elasticity of the ECM, and cod elastin is rich in amino acids such as glycine, proline, desmosine, and the like. Desmosine is an essential amino acid used to crosslink elastic fibers, maintain the function and structure of elastin, and play an important role in regulating skin contraction and relaxation. Proline and glycine can promote the synthesis of elastin in human dermal fibroblasts;
(5) ultraviolet resistance: ultraviolet rays are the most important pollution source in environmental pollution sources, and can enable skin metabolism to release more free radicals, destroy skin cell membranes and cause premature senility or death of the skin. The star flower extract is water-soluble extract obtained by leaching flowers, leaves and stems of Limoniummulgare (Limoniummulgare) and contains UV double-effect protection factor, and the damage of UVB/UVA to skin cells can be obviously prevented by 0.5% of addition amount;
(6) removing wrinkles instantly: cyclopenta dimethyl siloxane/dimethyl polysiloxane/vinyl dimethyl siloxane cross-linked polymer belongs to silicon elastomer, can bring silky smooth feeling to skin, is not sticky, has strong powdery feeling, and can immediately smooth wrinkles.
(7) Relieving and anti-allergy: the skin can have the uncomfortable phenomena of redness, itching, dryness and the like when being stimulated, the Astragalus Membranaceus (Astragalis Membranaceus) root extract is carefully matched with the Astragalus Membranaceus, the divaricate saposhnikovia root, the tall gastrodia tuber, the calendula officinalis and the silktree albizzia herb according to the formula principle of 'monarch, minister, assistant and guide' in the traditional Chinese medicine, has good effects of relieving and anti-allergy, and has the effects of soothing, relieving itching, dispelling redness, diminishing swelling, repairing after allergy and the like.
As a further example of the implementation of the method,
the emulsifier is cetyl PEG/PPG-10/1 polydimethylsiloxane, cyclopentadimethylsiloxane (and) PEG/PPG-18/18 polydimethylsiloxane (and) cyclohexasiloxane;
or the emulsifier is cetyl PEG/PPG-10/1 polydimethylsiloxane, polydimethylsiloxane/PEG-10/15 cross-linked polymer;
or the emulsifier is cetyl PEG/PPG-10/1 polydimethylsiloxane, lauryl PEG-9 polydimethylsiloxane ethyl polydimethylsiloxane.
In this example, cetyl PEG/PPG-10/1 PDMS has a strong emulsifying ability, and in cooperation with another emulsifier, it makes the emulsifying system more stable.
As a further example, the humectant is one or more than two of glycerin, propylene glycol, and sodium hyaluronate.
As a further example, the antifreeze agent is sodium chloride.
As a further example, the preservative is one or two of hexylene glycol, phenoxyethanol/ethylhexylglycerin.
As a further example, cyclopentadimethylsiloxane (and) PEG/PPG-18/18 dimethicone (and) cyclohexasiloxane 7%, cetyl PEG/PPG-10/1 dimethicone 1%, ethylhexyl palmitate 1%, cyclopentadimethylsiloxane 4%, dimethicone 0.5%, cyclopentadimethylsiloxane/dimethicone/vinyl dimethicone crosspolymer 1.2%, and tocopherol acetate 0.3%;
12% of glycerol, 10% of propylene glycol, 0.03% of sodium hyaluronate, 1.2% of sodium chloride, 0.35% of 1, 2-hexanediol and 0.6% of phenoxyethanol/ethylhexyl glycerol;
palmitoyl tripeptide-1/palmitoyl tetrapeptide-71.0%, kapok leaf extract 1.0% -2.0%, sea urchin collagen 0.8%, cod elastin 1.5%, star flower extract 1.0%, astragalus membranaceus root extract 0.8%, and essence 0.1%;
the balance being water.
The essence cream prepared according to the formula of the embodiment has relatively low raw material cost and ensures a good use effect, namely, the essence cream of the embodiment has good cost performance.
As a further example, the preparation process of the essence cream comprises,
(1) cleaning related production equipment for later use;
(2) weighing the components of the group A and the group D in a first stirring container, stirring at 25 rpm at normal temperature for 15 minutes, and fully stirring to obtain a first mixture for later use;
(3) weighing the components of the group B and the group C in a second stirring container, stirring at 15 r/min at normal temperature for 15 minutes, and fully stirring to obtain a second mixture for later use;
(4) slowly adding 4% of the second mixture into the first mixture at 9 rpm within 6 minutes; then, the stirring speed was slowly increased from 9 rpm to 21 rpm, and during the increasing, the remaining 96% of the second mixture was added to the first mixture over 9 minutes; then, the stirring speed is increased to 45 revolutions per minute, and the stirring is carried out for 8 minutes;
(5) sampling, detecting, discharging and filling.
In the preparation process of the essence cream, the first mixture is an oil phase, is viscous and thick, and the second mixture is a water phase and is very thin, so that the stirring speed in the step (2) is faster than that in the step (3), and the mixture can be stirred uniformly. The second mixture is added into the first mixture, namely the water phase is added into the oil phase to form a water-in-oil (W/O) system, so that the active ingredients in the second mixture are wrapped and are not easily oxidized, the product is not easy to discolor and delaminate, the quality is stable, the quality guarantee period is long, and the like, and meanwhile, the kapok leaf extract can better play the role. In addition, in the process, 4% of the second mixture is slowly added into the first mixture, and then the rest of the second mixture is added, so that the first mixture of the oil phase fully wraps the active ingredients in the second mixture of the water phase, and the obtained essence cream is not easy to deteriorate; simultaneously, the emulsion is also beneficial to better emulsification of the mixture, and a stable water-in-oil system is better formed, so that the obtained essence cream is not easy to stratify and is more stable.
In addition, the processing technology of the embodiment does not need heating or homogenizing and emulsifying, and only needs stirring and emulsifying in a stirring container, thereby achieving the purposes of saving energy and water and simultaneously preventing the active ingredients from being oxidized more quickly due to heating.
Compared with the prior art, the invention has the beneficial effects that:
1. the raw material of the invention is the kapok leaves, and the raw material is visible everywhere, is easy to obtain and has low collection cost. The extraction process adopts normal temperature extraction and low temperature filtration, and can reduce the content of ineffective impurities. The adopted butanediol is a commonly used humectant in skin care products, does not bring risks to the use of subsequent extracts, and can prevent system putrefaction and deterioration; in addition, butylene glycol can reduce the leaching of less polar substances, thereby reducing the content of ineffective impurities in the extract. The extract obtained by the extraction process has stable quality, and is not easy to have quality problems of precipitation, turbidity and the like.
2. The kapok leaf essence containing cream has the advantages of good anti-aging effect, long shelf life, moistening and moisturizing, and no stickiness.
Detailed Description
The present invention is further described below with reference to specific embodiments, and it should be noted that, without conflict, any combination between the embodiments or technical features described below may form a new embodiment.
The various starting components used in the examples are commercially available. Wherein cyclopentadimethylsiloxane (and) PEG/PPG-18/18 polydimethylsiloxane (and) cyclohexasiloxane is available from Dow chemical industry Co., Ltd, Guangzhou city Wanlu chemical industry Co., Ltd, polydimethylsiloxane/PEG-10/15 cross-linked polymer is available from Nippon Xinyu chemical industry Co., Ltd, phenoxyethanol/ethylhexylglycerin is available from Shume/Guangzhou city Baihao Co., Ltd, palmitoyl tripeptide-1/palmitoyl tetrapeptide-7 is available from Guangzhou Youyuan Biotech Co., Ltd, Hemicacai collagen is available from Dermalab/Guangzhou Enable force trade Co., Ltd, cod elastin is available from Dermalab/Guangzhou Enable force trade Co., Ltd, France cottage extract is available from Codif/Guangzhou Enable force trade Co., Ltd, astragalus Membranaceus (Astragalus Membranaceus) root extract was obtained from vast forest Biotech, Inc., Beijing east.
Extraction process of kapok leaf extract
Extraction process example 1:
(1) washing the kapok leaves with deionized water, drying, crushing, and sieving with a 20-mesh sieve;
(2) adding 1 part of crushed kapok leaves, 4 parts of butanediol and 5 parts of deionized water into a container, soaking at normal temperature for 72-75h, and stirring once every 5-15h to obtain a leaching matter;
(3) placing the extract obtained in the step (2) in an environment of 3-5 ℃ for 48-50h, and filtering to obtain filtrate;
(4) and (4) filling the filtrate obtained in the step (3) into a clean container, and placing the container at normal temperature for later use.
Extraction process example 2:
(1) washing the kapok leaves with deionized water, drying, crushing, and sieving with a 20-mesh sieve;
(2) adding 2 parts of crushed kapok leaves, 5 parts of butanediol and 3 parts of deionized water into a container, soaking at normal temperature for 72 hours, and stirring once every 5-15 hours to obtain a leaching matter;
(3) placing the extract obtained in the step (2) in an environment of 3-5 ℃ for 48h, and filtering to obtain filtrate;
(4) and (4) filling the filtrate obtained in the step (3) into a clean container, and placing the container at normal temperature for later use.
In the above embodiment, the principle of the kapok leaf extract extraction is as follows: firstly, water/butanediol diffuses to the cell wall of cells through capillaries inside kapok leaves; secondly, water/butanediol passes through the cell wall into the interior of the cell; then, the water/butanediol dissolves hydrophilic polysaccharide, glycoside, amino acid and other components in the cell to form a solution, and the water/butanediol continuously diffuses into the cell due to the concentration difference of the solution inside and outside the cell wall until the cell wall is burst by water/butanediol molecules; furthermore, molecules of components such as polysaccharide, glycoside and amino acid in the kapok leaves diffuse to the interface of the kapok leaves and water/butanediol; and finally, further diffusing the components such as polysaccharide, glycoside and amino acid in the kapok leaves into a water/butanediol system from the interface of the kapok leaves and water/butanediol.
The "crushing" step in the extraction process has a significant effect on the two stages of penetration and diffusion in the kapok leaf extraction process. If the crushing is fine, the fat-soluble oil ester is likely to be leached; on the contrary, if the powder is not crushed or not crushed to be fine enough, the speed of water/butanediol entering cells and the speed of leaching and diffusing components such as polysaccharide, glycoside and amino acid are slow, which is not beneficial to the extraction process.
The extraction process does not need to be carried out under heating conditions, because components such as polysaccharides, glycosides, amino acids, etc. can be dissolved in water at normal temperature, and only the leaching speed is slow. However, if the heat leaching is carried out, the leaching amount of the ineffective impurities is greatly increased, thereby increasing the risk of the subsequent use of the extract.
According to long-term accumulated practical experience, the general leaching time period needs 72-75 h. If the leaching time is too short, the components such as polysaccharide, glycoside and amino acid cannot be fully leached; conversely, when the leaching is carried out to reach saturation, too long a time has no practical significance. And secondly, in the leaching process, the components such as polysaccharide, glycosides and amino acid are continuously stirred, so that the components can be favorably diffused to a solvent, and the extraction effect can be favorably improved.
And finally, storing the extract at 3-5 ℃ for 48-50h, which is beneficial to full precipitation of weak-polarity components, and then filtering to obtain filtrate. When the filtrate is returned to normal temperature, the extract is stable, and quality problems such as precipitation, turbidity and the like are not easy to occur.
Furthermore, the preferable dosage of the butanediol is 4-5 parts, which is beneficial to the system preservation, reduces the use risk of subsequent extracts and also reduces the leaching of ineffective impurities.
Therefore, the extraction process of the kapok leaf extract is simple and easy to operate, and the kapok leaf extract extracted by the extraction process is stable in quality and is not easy to precipitate, become turbid and the like.
Secondly, the components of the essence cream
Sample example 1:
the component A comprises: cyclopentadimethylsiloxane (and) PEG/PPG-18/18 dimethicone (and) cyclohexasiloxane 7.0%, cetyl PEG/PPG-10/1 dimethicone 1.0%, ethylhexyl palmitate 0.5%, cyclopentadimethylsiloxane 4.0%, dimethicone 0.5%, cyclopentadimethylsiloxane/dimethicone/vinyl dimethicone crosspolymer 0.8%, tocopherol acetate 0.3%;
and B component: 12.0% of glycerin, 10.0% of propylene glycol, 0.0% of sodium hyaluronate, 1.2% of sodium chloride, 0.35% of 1, 2-hexanediol, 0.6% of phenoxyethanol/ethylhexyl glycerin and water (to 100%, namely the balance of water);
and C, component C: palmitoyl tripeptide-1/palmitoyl tetrapeptide-70.5%, kapok leaf extract 1.0%, sea urchin collagen 0.5%, cod elastin 0.8%, star flower extract 0.5%, Astragalus Membranaceus (Astragalus Membranaceus) root extract 0.5%; wherein, the kapok leaf extract is extracted by adopting the way of the extraction process example 1;
and (D) component: 0.1 percent of essence.
Sample example 2:
the component A comprises: cyclopentadimethylsiloxane (and) PEG/PPG-18/18 dimethicone (and) cyclohexasiloxane 7.0%, cetyl PEG/PPG-10/1 dimethicone 1.0%, ethylhexyl palmitate 1.0%, cyclopentadimethylsiloxane 4.0%, dimethicone 0.5%, cyclopentadimethylsiloxane/dimethicone/vinyl dimethicone crosspolymer 1.2%, tocopherol acetate 0.3%;
and B component: 12.0% of glycerin, 10.0% of propylene glycol, 0.03% of sodium hyaluronate, 1.2% of sodium chloride, 0.35% of 1, 2-hexanediol, 0.6% of phenoxyethanol/ethylhexyl glycerin and water (to 100%, namely the balance of water);
and C, component C: palmitoyl tripeptide-1/palmitoyl tetrapeptide-71.0%, kapok leaf extract 2.0%, sea urchin collagen 0.8%, cod elastin 1.5%, star flower extract 1.0%, Astragalus Membranaceus (Astragalus Membranaceus) root extract 0.8%; wherein, the kapok leaf extract is extracted by adopting the way of the extraction process example 1;
and (D) component: 0.1 percent of essence.
Sample example 3:
the component A comprises: dimethicone/PEG-10/15 crosspolymer 6.0%, cetyl PEG/PPG-10/1 dimethicone 1.0%, ethylhexyl palmitate 1.0%, cyclopentadimethicone 4.0%, dimethicone 0.5%, cyclopentadimethicone/dimethicone/vinyl dimethicone crosspolymer 2.0%, tocopherol acetate 0.3%;
and B component: 12.0% of glycerin, 10.0% of propylene glycol, 0.1% of sodium hyaluronate, 1.2% of sodium chloride, 0.35% of 1, 2-hexanediol, 0.6% of phenoxyethanol/ethylhexyl glycerin and water (to 100%, namely the balance of water);
and C, component C: palmitoyl tripeptide-1/palmitoyl tetrapeptide-71.5%, kapok leaf extract 3.0%, sea urchin collagen 1.3%, cod elastin 3.0%, star flower extract 1.5%, Astragalus Membranaceus (Astragalus Membranaceus) root extract 1.2%; wherein, the kapok leaf extract is extracted by adopting the way of the extraction process example 1;
and (D) component: 0.1 percent of essence.
Sample example 4:
the component A comprises: lauryl PEG-9 Dimethylsiloxyethyl polydimethylsiloxane 4.0%, cetyl PEG/PPG-10/1 Dimethicone 1.0%, ethylhexyl palmitate 1.0%, Cyclopentadimethicone 4.0%, Dimethicone 0.5%, Cyclopentadimethicone/Dimethicone/vinyl Dimethicone Crosspolymer 2.0%, Tocopherol acetate 0.3%;
and B component: 12.0% of glycerin, 10.0% of propylene glycol, 0.1% of sodium hyaluronate, 1.2% of sodium chloride, 0.35% of 1, 2-hexanediol, 0.6% of phenoxyethanol/ethylhexyl glycerin and water (to 100%, namely the balance of water);
and C, component C: palmitoyl tripeptide-1/palmitoyl tetrapeptide-73.0%, kapok leaf extract 4.0%, echinocandin 2.0%, cod elastin 4.0%, star flower extract 2.0%, Astragalus Membranaceus (Astragalus Membranaceus) root extract 2.0%; wherein, the kapok leaf extract is extracted by adopting the way of the extraction process example 1;
and (D) component: 0.1 percent of essence.
Sample example 5:
the component A comprises: cyclopentadimethylsiloxane (and) PEG/PPG-18/18 dimethicone (and) cyclohexasiloxane 7.0%, cetyl PEG/PPG-10/1 dimethicone 1.0%, ethylhexyl palmitate 1.0%, cyclopentadimethylsiloxane 4.0%, dimethicone 0.5%, cyclopentadimethylsiloxane/dimethicone/vinyl dimethicone crosspolymer 1.2%, tocopherol acetate 0.3%;
and B component: 12.0% of glycerin, 10.0% of propylene glycol, 0.03% of sodium hyaluronate, 1.2% of sodium chloride, 0.35% of 1, 2-hexanediol, 0.6% of phenoxyethanol/ethylhexyl glycerin and water (to 100%, namely the balance of water);
and C, component C: palmitoyl tripeptide-1/palmitoyl tetrapeptide-71.0%, kapok leaf extract 0.0%, sea urchin collagen 0.8%, cod elastin 1.5%, star flower extract 1.0%, Astragalus Membranaceus (Astragalus Membranaceus) root extract 0.8%; wherein, the kapok leaf extract is extracted by adopting the way of the extraction process example 1;
and (D) component: 0.1 percent of essence.
Sample example 6:
the component A comprises: cyclopentadimethylsiloxane (and) PEG/PPG-18/18 dimethicone (and) cyclohexasiloxane 7.0%, cetyl PEG/PPG-10/1 dimethicone 1.0%, ethylhexyl palmitate 1.0%, cyclopentadimethylsiloxane 4.0%, dimethicone 0.5%, cyclopentadimethylsiloxane/dimethicone/vinyl dimethicone crosspolymer 1.2%, tocopherol acetate 0.3%;
and B component: 12.0% of glycerin, 10.0% of propylene glycol, 0.03% of sodium hyaluronate, 1.2% of sodium chloride, 0.35% of 1, 2-hexanediol, 0.6% of phenoxyethanol/ethylhexyl glycerin and water (to 100%, namely the balance of water);
and C, component C: palmitoyl tripeptide-1/palmitoyl tetrapeptide-71.0%, kapok leaf extract 1.0%, sea urchin collagen 0.8%, cod elastin 1.5%, star flower extract 1.0%, Astragalus Membranaceus (Astragalus Membranaceus) root extract 0.8%; wherein, the kapok leaf extract is extracted by adopting the way of the extraction process example 1;
and (D) component: 0.1 percent of essence.
Sample example 7:
the component A comprises: cyclopentadimethylsiloxane (and) PEG/PPG-18/18 dimethicone (and) cyclohexasiloxane 7.0%, cetyl PEG/PPG-10/1 dimethicone 1.0%, ethylhexyl palmitate 1.0%, cyclopentadimethylsiloxane 4.0%, dimethicone 0.5%, cyclopentadimethylsiloxane/dimethicone/vinyl dimethicone crosspolymer 1.2%, tocopherol acetate 0.3%;
and B component: 12.0% of glycerin, 10.0% of propylene glycol, 0.03% of sodium hyaluronate, 1.2% of sodium chloride, 0.35% of 1, 2-hexanediol, 0.6% of phenoxyethanol/ethylhexyl glycerin and water (to 100%, namely the balance of water);
and C, component C: palmitoyl tripeptide-1/palmitoyl tetrapeptide-71.0%, kapok leaf extract 3.0%, sea urchin collagen 0.8%, cod elastin 1.5%, star flower extract 1.0%, Astragalus Membranaceus (Astragalus Membranaceus) root extract 0.8%; wherein, the kapok leaf extract is extracted by adopting the way of the extraction process example 1;
and (D) component: 0.1 percent of essence.
In the above examples, palmitoyl tripeptide-1/palmitoyl tetrapeptide-7 can enhance cell activity and improve skin microcirculation; the kapok leaf extract contains components such as polysaccharide, glycosides and amino acid, can eliminate peroxide free radicals, and has the effects of resisting oxidation and aging; sea urchin collagen improves skin elasticity and restores skin youth by promoting collagen synthesis; cod elastin is rich in amino acids such as glycine, proline, desmosine, etc., and supplements elastin; the extract of star flower can resist ultraviolet; the cyclopenta dimethyl silicone polymer/vinyl dimethyl silicone polymer cross-linked polymer can bring silky smooth feeling to the skin, is not sticky, has strong powdery feeling, and can smooth wrinkles instantly; the extract of the root of the astragalus membranaceus (astraglus membranaceus) has good effects of relieving and resisting allergy, soothing and relieving itching, dispelling redness and swelling, repairing after allergy and the like; the glycerin, the propylene glycol and the sodium hyaluronate play a role in moisturizing; the sodium chloride improves the frost resistance of the essence cream; the hexylene glycol and the phenoxyethanol/ethylhexyl glycerin improve the antiseptic capability of the essence cream so as to better ensure the efficacy of the essence cream; cyclopenta-dimethyl siloxane (and) PEG/PPG-18/18 polydimethylsiloxane (and) cyclohexasiloxane, polydimethylsiloxane/PEG-10/15 cross-linked polymer, lauryl PEG-9 polydimethylsiloxane ethyl polydimethylsiloxane, and cetyl PEG/PPG-10/1 polydimethylsiloxane are used as emulsifiers, so that the stability of the whole system of the essence cream is ensured. The components in the embodiment supplement each other, so that the essence cream can comprehensively solve the aging problem, moisten and moisturize, is not sticky, has a good anti-aging effect, and is not easy to deteriorate.
Preparation method of essence cream
The essence creams of sample examples 1 to 7 were prepared by combining the above-mentioned components of sample examples 1 to 7, respectively, according to the following steps:
(1) cleaning related production equipment for later use;
(2) weighing the components of the group A and the group D in a first stirring container, stirring at 25 rpm at normal temperature for 15 minutes, and fully stirring to obtain a first mixture for later use;
(3) weighing the components of the group B and the group C in a second stirring container, stirring at 15 r/min at normal temperature for 15 minutes, and fully stirring to obtain a second mixture for later use;
(4) slowly adding 4% of the second mixture into the first mixture at 9 rpm within 6 minutes; then, the stirring speed was slowly increased from 9 rpm to 21 rpm, and during the increasing, the remaining 96% of the second mixture was added to the first mixture over 9 minutes; then, the stirring speed is increased to 45 revolutions per minute, and the stirring is carried out for 8 minutes;
(5) sampling, detecting, discharging and filling.
In the preparation method of the essence cream, the first mixture is an oil phase and is viscous and thick, and the second mixture is a water phase and is very thin, so that the stirring speed in the step (2) is higher than that in the step (3) so as to be better stirred. The second mixture is added into the first mixture, namely the water phase is added into the oil phase to form a water-in-oil (W/O) system, so that the active ingredients in the second mixture are wrapped and are not easily oxidized, the product is not easily discolored, the quality is stable, the quality guarantee period is long, and the like, and meanwhile, the kapok leaf extract can better play the role. In addition, in the process, 4% of the second mixture is slowly added to the first mixture, and then the rest of the second mixture is added, so that the first mixture of the oil phase is favorable for wrapping the active ingredients in the second mixture to better form a stable water-in-oil system; meanwhile, the mixture is favorably emulsified better, so that the obtained essence cream is not easy to layer, deteriorate and the like.
In addition, the processing technology of the embodiment does not need heating or homogenizing and emulsifying, and only needs stirring and emulsifying in a stirring container, thereby achieving the purposes of saving energy and water and simultaneously preventing the active ingredients from being oxidized more quickly due to heating.
Fourth, performance test of the essence cream
The samples of the essence cream of examples 1 to 4 were compared with a sample of a commercially available Japaneseh Anti-Wrinkle cream (Timezone Night Anti-Line/Wrinkle Creme) of a control group. The detection result shows that the anti-aging and anti-wrinkle effect of the essence cream of the sample examples 2 to 4 is better than that of the commercially available Yashilan indigo anti-wrinkle cream. The specific test method and data analysis are as follows:
test one: sample examples 1-4 and control group anti-aging wrinkle removal test
1. Test samples: samples the serum samples of examples 1-4, a control commercially available sample of ashira antiwrinkle cream;
2. selecting a crowd: the age group is 35-55 years old, and 50 men and women respectively;
3. test site: guangzhou;
4. test time: 11 months in 2018-1 month in 2019;
5. the test method comprises the following steps:
the distribution was randomly averaged for each half of the population. The medicine is used twice a day after cleaning face in the morning and evening. Other skin care products are forbidden during product trial. The test is carried out continuously for 8 weeks, data are collected once a week, and the face is cleaned 2 hours before the data are collected.
A facial image analyzer VISIA6 from Canfield, usa, was used to take high-definition pictures of the face with a 1200-ten-thousand-pixel camera, and then subjected to quantitative image analysis processing for comparative ranking of skin features with those of the same condition (same age, gender and skin type). If the subject's wrinkles are fine and shallow, the measured percentage value (T) is large, i.e., ranked top compared to 100 individuals in the database; if the subject has large, deep wrinkles, the measured percentage value (T) is small, i.e., ranked later than 100 in the database.
TABLE 1 mean T values of test subjects as a function of time
Analysis and conclusion 1:
(1) as shown in table 1, it can be seen that the anti-aging and wrinkle-removing effects of the sample examples 2 to 4 are more excellent by comparing the essence creams of the sample examples 1 to 4 with the control sample.
(2) By statistical analysis, paired t-test:
in the formula: t isn-the value of the change in time of the subject,
T0-pre-product non-use value of subject.
From the above equation: the average change rate in use of sample example 1 was 26.51%, the average change rate in use of sample example 2 was 44.46%, the average change rate in use of sample example 3 was 53.97%, and the average change rate in use of sample example 4 was 52.53%; the average rate of change in use for the control group was 32.61%.
It can be seen that the anti-aging and anti-wrinkle effects of the samples of examples 2 to 4 are all better than those of the control group. In addition, comparing sample examples 1 to 4, since the active ingredients of group C ingredients in sample examples 3 and 4 are more than those in sample examples 1 and 2, in order to ensure the stability of the system of sample examples 3 and 4, the emulsifying power of the emulsifying agent (i.e., dimethicone/PEG-10/15 cross-linked polymer, lauryl PEG-9 dimethiconoethyl dimethicone) selected for sample examples 3 and 4 is stronger than that of sample examples 1 and 2, so that the anti-wrinkle effect of sample examples 3 and 4 is slightly better than that of sample example 2 as a whole, but the preparation cost is greatly increased. Second, sample example 1 was very inexpensive to prepare, but was much less effective than example 2. The anti-aging and wrinkle-removing effects of sample example 2 are not much different from those of sample examples 3 and 4, and the manufacturing cost is much lower than those of sample examples 3 and 4.
Therefore, in summary, the essence cream prepared according to the sample formulation of sample example 2 is the most cost-effective.
And (2) test II: determination of the amount of kapok leaf extract added
The other components of the sample example 2 were added in the same amounts, and the above test method was used to obtain:
sample example 5: when the kapok leaf extract was not added, the T value after 5 to 8 weeks was about 64.8%;
sample example 6: when the kapok leaf extract is added at 1%, the T value after 5 to 8 weeks is about 72.0%;
sample example 2: when the kapok leaf extract is added at 2%, the T value after 5 to 8 weeks is about 77.7%;
sample example 7: when 3% of the kapok leaf extract was added, the T value after 5 to 8 weeks was approximately 78.6%.
Analysis and conclusion 2:
sample example 2 has a certain anti-aging and wrinkle-removing effect when kapok leaf extract is not added (i.e., sample example 5); and after the kapok leaf extract is added, the anti-aging and wrinkle-removing effects are obviously enhanced. Secondly, the addition amount of the kapok leaf extract is 1 to 3 percent, which is more appropriate; if the addition of excessive extract is not practical, the waste is caused; on the other hand, if the amount is too low, the effect of the kapok leaf extract on resisting oxidation and aging cannot be exerted.
And (3) test III: sample examples 1-7 product safety testing
The test method comprises the following steps: according to the requirements of the technical Specification for safety of cosmetics, 30 test subjects were selected, and the skin care products of sample examples 1 to 7 were subjected to closed patch test, and skin reaction was observed by naked eyes 24 hours later. The degree of reaction and the grade scoring criteria are as follows.
TABLE 2 skin response grading Standard for skin Enclosed Patch test
Analysis and conclusion 3:
in sample example 1, 30 persons showed negative reaction, and 0 person showed suspicious reaction; in sample example 2, 30 persons reacted negatively and 0 person reacted suspiciously; in sample example 3, 30 persons reacted negatively and 0 persons reacted suspiciously; in sample example 4, 30 persons showed negative reaction, and 0 person showed suspicious reaction; in sample example 5, 30 persons showed negative reaction, and 0 person showed suspicious reaction; in sample example 6, 30 persons showed negative reaction, and 0 person showed suspicious reaction; in example 7, 30 persons showed negative reaction and 0 person showed suspicious reaction.
According to the judgment standard of the human skin patch experiment in the specification of cosmetic safety technology 2015, the sample examples 1-7 have no adverse reaction on human bodies.
The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.
Claims (10)
1. An extraction process of a kapok leaf extract is characterized by comprising the following steps: comprises the following steps of (a) carrying out,
(1) washing the kapok leaves with deionized water, drying, crushing, and sieving with a 20-mesh sieve;
(2) adding the crushed kapok leaves, butanediol and deionized water into a container, soaking at normal temperature for 72-75h, and stirring once every 5-15h to obtain a leaching matter;
(3) placing the extract obtained in the step (2) in an environment of 3-5 ℃ for 48-50h, and filtering to obtain filtrate;
(4) and (4) filling the filtrate obtained in the step (3) into a clean container, and placing the container at normal temperature for later use.
2. The extraction process of kapok leaf extract according to claim 1, wherein: taking 1-2 parts of kapok leaves, 4-5 parts of butanediol and 3-5 parts of deionized water in the step (2).
3. The extraction process of kapok leaf extract as claimed in claim 2, wherein: taking 1 part of kapok leaves, 4 parts of butanediol and 5 parts of deionized water in the step (2).
4. An essence cream, comprising: the component A, the component B, the component C and the component D; wherein,
the component A comprises an emulsifier, ethylhexyl palmitate, cyclopentadimethylsiloxane, polydimethylsiloxane, cyclopentadimethylsiloxane/polydimethylsiloxane/vinyl polydimethylsiloxane crosspolymer and tocopherol acetate;
the component B comprises a humectant, an antifreeze, a preservative and water;
the C component comprises palmitoyl tripeptide-1/palmitoyl tetrapeptide-7, folium gossypii extract, sea urchin collagen, cod elastin, star flower extract and Astragalus membranaceus root extract; the kapok leaf extract is extracted by adopting the extraction process of the kapok leaf extract as described in any one of the claims 1 to 3;
the component D comprises essence.
5. The essence of claim 4, wherein: the emulsifier is cetyl PEG/PPG-10/1 polydimethylsiloxane, cyclopentadimethylsiloxane (and) PEG/PPG-18/18 polydimethylsiloxane (and) cyclohexasiloxane;
or the emulsifier is cetyl PEG/PPG-10/1 polydimethylsiloxane, polydimethylsiloxane/PEG-10/15 cross-linked polymer;
or the emulsifier is cetyl PEG/PPG-10/1 polydimethylsiloxane, lauryl PEG-9 polydimethylsiloxane ethyl polydimethylsiloxane.
6. The essence of claim 4, wherein: the humectant is one or more than two of glycerin, propylene glycol and sodium hyaluronate.
7. The essence of claim 4, wherein: the antifreeze agent is sodium chloride.
8. The essence of claim 4, wherein: the preservative is one or two of hexylene glycol, phenoxyethanol and ethylhexyl glycerin.
9. The essence of claim 4, wherein:
cyclopentadimethylsiloxane (and) PEG/PPG-18/18 polydimethylsiloxane (and) cyclohexasiloxane 7%, cetyl PEG/PPG-10/1 polydimethylsiloxane 1%, ethylhexyl palmitate 1%, cyclopentadimethylsiloxane 4%, polydimethylsiloxane 0.5%, cyclopentadimethylsiloxane/polydimethylsiloxane/vinyl polydimethylsiloxane crosspolymer 1.2%, and tocopheryl acetate 0.3%;
12% of glycerol, 10% of propylene glycol, 0.03% of sodium hyaluronate, 1.2% of sodium chloride, 0.35% of 1, 2-hexanediol and 0.6% of phenoxyethanol/ethylhexyl glycerol;
palmitoyl tripeptide-1/palmitoyl tetrapeptide-71.0%, kapok leaf extract 1.0% -3.0%, sea urchin collagen 0.8%, cod elastin 1.5%, star flower extract 1.0%, astragalus membranaceus root extract 0.8%, and essence 0.1%;
the balance being water.
10. The essence of claim 4, wherein: the preparation process of the essence cream comprises the following steps,
(1) cleaning related production equipment for later use;
(2) weighing the components of the group A and the group D in a first stirring container, stirring at 25 rpm at normal temperature for 15 minutes, and fully stirring to obtain a first mixture for later use;
(3) weighing the components of the group B and the group C in a second stirring container, stirring at 15 r/min at normal temperature for 15 minutes, and fully stirring to obtain a second mixture for later use;
(4) slowly adding 4% of the second mixture into the first mixture at 9 rpm within 6 minutes; then, the stirring speed was slowly increased from 9 rpm to 21 rpm, and during the increasing, the remaining 96% of the second mixture was added to the first mixture over 9 minutes; then, the stirring speed is increased to 45 revolutions per minute, and the stirring is carried out for 8 minutes;
(5) sampling, detecting, discharging and filling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911308035.0A CN111012705A (en) | 2019-12-18 | 2019-12-18 | Extraction process of kapok leaf extract and essence cream thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911308035.0A CN111012705A (en) | 2019-12-18 | 2019-12-18 | Extraction process of kapok leaf extract and essence cream thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111012705A true CN111012705A (en) | 2020-04-17 |
Family
ID=70209451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911308035.0A Pending CN111012705A (en) | 2019-12-18 | 2019-12-18 | Extraction process of kapok leaf extract and essence cream thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111012705A (en) |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001072569A (en) * | 1999-09-08 | 2001-03-21 | Noevir Co Ltd | Skin preparation for external use |
| JP2009029710A (en) * | 2007-07-24 | 2009-02-12 | Maruzen Pharmaceut Co Ltd | Antioxidant, anti-aging agent, anti-inflammatory agent, hair restorer, anti-obesity agent, endothelin-1 mRNA expression increase inhibitor, and cosmetic and beauty food and drink |
| JP2014091718A (en) * | 2012-11-05 | 2014-05-19 | Sepa Sigma Inc | Pig-placenta essence cosmetic |
| US20160106799A1 (en) * | 2013-05-29 | 2016-04-21 | Siamab Therapeutics, Inc. | Carbohydrate Compounds for Nutritional and Therapeutic Use |
| CN105646464A (en) * | 2016-02-23 | 2016-06-08 | 中国药科大学 | Method for extracting high-purity mangiferin from bombax ceiba leaves |
| CN106420505A (en) * | 2016-12-01 | 2017-02-22 | 北京东方淼森生物科技有限公司 | Traditional Chinese medicine plant composition, and preparation method and application thereof |
| CN106913487A (en) * | 2017-04-25 | 2017-07-04 | 攀枝花学院 | Compound mango leaf extract face cream and preparation method thereof |
| CN107137263A (en) * | 2017-04-19 | 2017-09-08 | 北京赛尔佳人化妆品有限公司 | A kind of anti-ageing face mask liquid and preparation method thereof |
| CN107951770A (en) * | 2017-12-06 | 2018-04-24 | 绿馨颜（惠州）生物科技有限公司 | It is a kind of to remove wrinkle eye cream and preparation method thereof immediately |
| CN108276489A (en) * | 2018-04-09 | 2018-07-13 | 无限极（中国）有限公司 | Collagen and preparation method thereof, application |
-
2019
- 2019-12-18 CN CN201911308035.0A patent/CN111012705A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001072569A (en) * | 1999-09-08 | 2001-03-21 | Noevir Co Ltd | Skin preparation for external use |
| JP2009029710A (en) * | 2007-07-24 | 2009-02-12 | Maruzen Pharmaceut Co Ltd | Antioxidant, anti-aging agent, anti-inflammatory agent, hair restorer, anti-obesity agent, endothelin-1 mRNA expression increase inhibitor, and cosmetic and beauty food and drink |
| JP2014091718A (en) * | 2012-11-05 | 2014-05-19 | Sepa Sigma Inc | Pig-placenta essence cosmetic |
| US20160106799A1 (en) * | 2013-05-29 | 2016-04-21 | Siamab Therapeutics, Inc. | Carbohydrate Compounds for Nutritional and Therapeutic Use |
| CN105646464A (en) * | 2016-02-23 | 2016-06-08 | 中国药科大学 | Method for extracting high-purity mangiferin from bombax ceiba leaves |
| CN106420505A (en) * | 2016-12-01 | 2017-02-22 | 北京东方淼森生物科技有限公司 | Traditional Chinese medicine plant composition, and preparation method and application thereof |
| CN107137263A (en) * | 2017-04-19 | 2017-09-08 | 北京赛尔佳人化妆品有限公司 | A kind of anti-ageing face mask liquid and preparation method thereof |
| CN106913487A (en) * | 2017-04-25 | 2017-07-04 | 攀枝花学院 | Compound mango leaf extract face cream and preparation method thereof |
| CN107951770A (en) * | 2017-12-06 | 2018-04-24 | 绿馨颜（惠州）生物科技有限公司 | It is a kind of to remove wrinkle eye cream and preparation method thereof immediately |
| CN108276489A (en) * | 2018-04-09 | 2018-07-13 | 无限极（中国）有限公司 | Collagen and preparation method thereof, application |
Non-Patent Citations (2)
| Title |
|---|
| 台湾省来裕公司: "NEUROCOL Y 海胆胶原蛋白", 《台湾省来裕公司》 * |
| 安科丽: "戴上隔离面具，不再让肌肤继续"裸奔"", 《安科丽》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110755321A (en) | Composition for quick allergy relief and preparation method and application thereof | |
| CN110693756A (en) | Deep moisturizing composition and application thereof, and deep moisturizing mask | |
| CN108653142A (en) | A kind of moisture-keeping composition | |
| CN110302091B (en) | Composition containing nicotinamide adenine dinucleotide for resisting skin aging and preparation method and application thereof | |
| CN114177104A (en) | Anti-aging face cream | |
| WO2014182917A1 (en) | Formulations and methods for improving skin conditions | |
| CN105168054A (en) | Mask capable of supplementing water, whitening and removing wrinkles and preparation method of mask | |
| CN104958241A (en) | Moisturizing traditional Chinese medicine mask product and preparation method thereof | |
| LU93280B1 (en) | Cosmetic composition based on extracts of Avena sativa, Lens esculenta and Tropaeolum majus | |
| CN110090167B (en) | Biological polysaccharide for ultraviolet injury repair and application thereof | |
| CN114796024B (en) | Bionic sebum composition for skin barrier repair, and preparation method and application thereof | |
| CN110801412B (en) | Sebum bionic composition, application thereof and cosmetics | |
| CN110859791B (en) | Skin whitening composition and its application, skin whitening mask | |
| CN109453059B (en) | Whitening cosmetic additive, whitening sleep mask and preparation method of whitening cosmetic additive | |
| CN111135122A (en) | Composition containing ganoderma lucidum extract and application thereof in moisturizing and anti-wrinkle cosmetics | |
| CN110292543B (en) | Biological composition for replacing ultraviolet absorbent and application thereof | |
| CN115607502A (en) | Composition containing sweet osmanthus extract and application and cosmetic thereof | |
| CN114805485A (en) | Chlorella bioactive peptide and application thereof in preparation of anti-aging essence | |
| CN111743798B (en) | Multi-effect anti-aging skin care product and preparation method thereof | |
| CN114652628A (en) | Anti-aging cream for beautifying chest and body and enhancing skin immune barrier and preparation method thereof | |
| CN108771643A (en) | It is full of and moistens maintenance essence | |
| TW202106323A (en) | Use ofrosmarinus officinaliscallus extract for manufacturing composition inhibiting skin aging and a culture medium for inducingrosmarinus officinaliscallus | |
| CN111012705A (en) | Extraction process of kapok leaf extract and essence cream thereof | |
| CN105640836B (en) | A kind of surfactant and preparation method thereof containing lotus active constituent | |
| CN115887328A (en) | A kind of composite polypeptide liposome composition and its preparation method and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200417 |