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CN110721002B - Device of blood glucose is surveyed with blood sampling of mouse tail vein for experiments - Google Patents

Device of blood glucose is surveyed with blood sampling of mouse tail vein for experiments Download PDF

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CN110721002B
CN110721002B CN201910866130.6A CN201910866130A CN110721002B CN 110721002 B CN110721002 B CN 110721002B CN 201910866130 A CN201910866130 A CN 201910866130A CN 110721002 B CN110721002 B CN 110721002B
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blood
blood collection
mouse
needle
tail
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CN110721002A (en
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李红波
熊德富
郝佳晖
张一博
王文
倪李睿
孙俊杰
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Xian Medical University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D3/00—Appliances for supporting or fettering animals for operative purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15146—Devices loaded with multiple lancets simultaneously, e.g. for serial firing without reloading, for example by use of stocking means.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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Abstract

The invention discloses a device for measuring blood sugar by taking blood from tail veins of an experimental mouse, which comprises a bottom plate, wherein baffle plates are arranged around the bottom plate, a mouse positioning box is arranged on the bottom plate, a detachable box cover is arranged at the top of the mouse positioning box, a plurality of mouse tail extending holes are arranged on one side of the bottom of the mouse positioning box, and a blood taking mechanism is also arranged on the bottom plate. The invention solves the problem of low blood sampling efficiency of the traditional blood sampling mode, can effectively relieve the stress reaction of mice and improves the preparation rate of blood sugar measurement.

Description

Device of blood glucose is surveyed with blood sampling of mouse tail vein for experiments
Technical Field
The invention belongs to the technical field of blood sampling equipment, and relates to a device for measuring blood sugar by sampling blood from tail veins of an experimental mouse.
Background
The in-process does not have corresponding convenient device to the survey of mouse blood sugar for the experiment to current experiment development, and it is usually only many people of experimenter mutually support and accomplish the survey of mouse blood sugar, snatch and fix the mouse after, prick mouse tail vein with the blood taking needle and take a blood sample, and often cause the stress response nature blood sugar situation that the mouse rose at this in-process easily, and blood sampling efficiency is comparatively low moreover.
Disclosure of Invention
The invention aims to provide a device for measuring blood sugar by taking blood from tail veins of an experimental mouse, which solves the problem of low blood taking efficiency in the traditional blood taking mode, can effectively relieve the stress reaction of the mouse and improves the preparation rate of blood sugar measurement.
The technical scheme includes that the device for measuring the blood sugar by taking blood from the tail vein of the experimental mouse comprises a bottom plate, baffle plates are arranged on the periphery of the bottom plate, a mouse positioning box is arranged on the bottom plate, a detachable box cover is arranged at the top of the mouse positioning box, a plurality of mouse tail extending holes are formed in one side of the bottom of the mouse positioning box, and a blood taking mechanism is further arranged on the bottom plate.
The present invention is also characterized in that,
a layer of iron sheet is laid on the upper surface of the bottom plate, a magnet sheet A is arranged at the bottom of the mouse positioning box, and the mouse positioning box and the bottom plate are adsorbed together by the magnet sheet A;
the bottom of the blood sampling base is provided with a magnet piece B which adsorbs the blood sampling base on the bottom plate.
Mouse locating box and case lid are light-tight ya keli material.
The blood sampling mechanism comprises a blood sampling base, a groove for placing a mouse tail is formed in the upper surface of one end of the blood sampling base, the other end of the blood sampling base is connected with one end of a pressing plate through a rotating shaft, a spring is coaxially sleeved on the rotating shaft, one end of the spring is in contact with the lower surface of the pressing plate, the other end of the spring is in contact with the lower surface of the base, a blood sampling needle positioning sleeve is arranged at the other end of the pressing plate, and the blood sampling needle positioning sleeve is used for placing a blood sampling needle;
a circular needle hole is formed in the center of the blood taking needle positioning sleeve, and the needle tip of the blood taking needle extends out of the circular needle hole; the circular pinhole is positioned right above the groove.
The top of clamp plate is equipped with the gland, and the one end of gland is articulated with the one end of clamp plate, and the other end lock just of gland is at the other end upper surface of clamp plate, and the gland lid can prevent that the blood taking needle from popping out from the blood taking needle position sleeve on the clamp plate.
The upper surface of gland is equipped with handle B, conveniently pulls up the gland.
The invention has the following beneficial effects:
(1) the base plate, the mouse positioning box and the blood sampling mechanism form a detachable structure by utilizing the principle that the magnet and the iron attract each other, the mouse positioning box can move back and forth on the base plate, a mouse is placed in the mouse positioning box and moves along with the mouse positioning box, the tension can be properly relieved, and the stress response of an experimental mouse is reduced to a certain degree;
(2) the invention fills the gap of the blood sampling device special for the experimental mouse in the traditional measuring method, the blood sampling mechanism in the invention adopts a stapler type design, the convenience and the high efficiency of the blood sampling process are increased, meanwhile, the connection of the blood sampling device and the bottom plate improves the separation mode of the original blood sampling device and the bottom plate, the measuring environment is improved to a certain extent, and the measurement is well and orderly.
(3) The blood sampling and blood sugar measurement can be completed by only one operator by adopting the device disclosed by the invention, so that the labor is saved, and the blood sampling efficiency is improved.
Drawings
FIG. 1 is a schematic diagram showing the structure of a blood glucose measuring device for collecting blood from the tail vein of a laboratory mouse according to the present invention;
FIG. 2 is a schematic diagram showing the structure of a mouse positioning box in the device for measuring blood sugar by collecting blood from the tail vein of a laboratory mouse according to the present invention;
FIG. 3 is a schematic structural diagram of a blood sampling mechanism in the blood glucose measuring device for sampling blood from the tail vein of a laboratory mouse according to the present invention.
In the figure, 1, a box cover, 2, a mouse positioning box, 3, a tail extending hole, 4, a blood sampling mechanism, 5, a gland, 6, a blood sampling positioning sleeve, 7, a blood sampling base, 8, a bottom plate, 9, a baffle, 10, handles A, 11, handles B, 12, a groove, 13, a rotating shaft and 14, and a pressing plate.
Detailed Description
The present invention will be described in detail below with reference to the accompanying drawings and specific embodiments.
The invention relates to a device for measuring blood sugar by taking blood from tail veins of an experimental mouse, which comprises a bottom plate 8, wherein baffle plates 9 are arranged around the bottom plate 8, a layer of iron sheet is laid on the upper surface of the bottom plate 8, a mouse positioning box 2 is arranged on the bottom plate 8, a detachable box cover 1 is arranged at the top of the mouse positioning box 2, a handle A10 is arranged at the top of the box cover 1, a plurality of mouse tail extension holes 3 are arranged on one side of the bottom of the mouse positioning box 2, and the mouse tail extension holes 3 are arranged at equal intervals;
the bottom of mouse positioning box 2 is equipped with magnet piece A, and magnet piece A adsorbs mouse positioning box 2 and bottom plate 8 together.
Mouse locating box 2 and case lid 1 are light tight ya keli material.
The bottom plate 8 is also provided with a blood sampling mechanism 4, the blood sampling mechanism 4 comprises a blood sampling base 7, the upper surface of one end of the blood sampling base 7 is provided with a groove 12, and the shape of the groove 12 is adapted to the shape of the tail of the mouse; the other end of the blood taking base 7 is connected with one end of a pressing plate 14 through a rotating shaft 13, a spring is coaxially sleeved on the rotating shaft 13, one end of the spring is in contact with the lower surface of the pressing plate 14, the other end of the spring is in contact with the lower surface of the base 7, a blood taking needle positioning sleeve 6 is arranged at the other end of the pressing plate 14, and the blood taking needle positioning sleeve 6 is used for placing a blood taking needle;
a circular needle hole is formed in the center of the blood taking needle positioning sleeve 6, and the needle tip of the blood taking needle extends out of the circular needle hole, so that blood taking is facilitated; the circular pinhole is positioned right above the groove 12.
A gland 5 is arranged above the pressing plate 14, one end of the gland 5 is hinged with one end of the pressing plate 14, the other end of the gland 5 is just buckled on the upper surface of the other end of the pressing plate 14, and the gland 5 is covered on the pressing plate 14 to prevent the blood taking needle from being ejected out of the blood taking needle positioning sleeve 6;
the upper surface of the gland 5 is provided with a handle B11 to facilitate the pulling of the gland 5.
The bottom of the blood sampling base 7 is provided with a magnet piece B, and the magnet piece B absorbs the blood sampling base 7 on the bottom plate 8.
The invention relates to a use method of a device for measuring blood sugar by taking blood from tail veins of an experimental mouse, which comprises the following steps of firstly putting a needle head of a blood taking needle downwards into a blood taking needle positioning sleeve 6 before use, and extending the needle head of the blood taking needle out of a circular needle hole;
when the mouse positioning box is used, padding is laid on the bottom plate 8, an experimental mouse is placed on the bottom plate 8, the box cover 1 is opened, the experimental mouse is placed in the mouse positioning box 2, the mouse tail penetrates out of the mouse tail extending hole 3 in the proper position and is placed on the groove 12, after the mouse positioning box is used, the mouse tail is fixed by the left hand, the blood taking needle is pressed down on the pressing cover 5 by the right hand, the blood taking needle punctures the tip vein of the tail of the experimental mouse, then the blood glucose detector provided with the blood glucose test paper is held by the right hand, and blood glucose measurement can be carried out after blood overflows. If the blood sampling mechanism 4 is used for the first time and the blood sampling is not successful, the left hand can be used for repeatedly squeezing the blood sampling needle to prick the part, so that the blood at the tail of the rat is prompted to overflow and the blood is measured again.

Claims (1)

1.一种实验用鼠尾静脉采血测定血糖的装置，其特征在于：包括底板，底板的四周设置挡板，底板上设有小鼠定位箱，小鼠定位箱的顶部设有可拆卸的箱盖，小鼠定位箱的底部一侧设有若干鼠尾伸出孔，底板上还设有采血机构；1. a device for measuring blood glucose by blood sampling from rat tail veins in an experiment, is characterized in that: comprise base plate, the periphery of base plate is provided with baffle plate, and the base plate is provided with mouse positioning box, and the top of mouse positioning box is provided with detachable box The bottom side of the mouse positioning box is provided with a number of rat tail protruding holes, and the bottom plate is also provided with a blood collection mechanism; 所述底板的上表面铺设有一层铁皮，小鼠定位箱的底部设有磁铁片A，磁铁片A将小鼠定位箱与底板吸附在一起；The upper surface of the bottom plate is covered with a layer of iron, and the bottom of the mouse positioning box is provided with a magnet piece A, and the magnet piece A adsorbs the mouse positioning box and the bottom plate together; 采血底座的底部设有磁铁片B，磁铁片B将采血底座吸附在底板上；The bottom of the blood collection base is provided with a magnet piece B, and the magnet piece B attaches the blood collection base to the bottom plate; 所述采血机构包括采血底座，采血底座的一端上表面设有用于放置小鼠尾巴的凹槽，采血底座的另一端通过转轴连接压板的一端，转轴上同轴套接有弹簧，所述弹簧的一端与压板的下表面接触，所述弹簧的另一端与底座的下表面接触，压板的另一端设有采血针定位套筒，采血针定位套筒用于放置采血针；The blood collection mechanism includes a blood collection base, one end of the blood collection base is provided with a groove for placing the mouse tail, the other end of the blood collection base is connected to one end of the pressure plate through a rotating shaft, and a spring is coaxially sleeved on the rotating shaft, and the spring One end is in contact with the lower surface of the pressure plate, the other end of the spring is in contact with the lower surface of the base, the other end of the pressure plate is provided with a blood collection needle positioning sleeve, and the blood collection needle positioning sleeve is used for placing the blood collection needle; 采血针定位套筒的中心处开设有圆形针孔，采血针的针尖从圆形针孔中伸出；圆形针孔位于凹槽的正上方；The center of the lancet positioning sleeve is provided with a circular pinhole, and the needle tip of the lancet protrudes from the circular pinhole; the circular pinhole is located just above the groove; 所述压板的上方设有压盖，压盖的一端与压板的一端铰接，压盖的另一端恰好扣合在压板的另一端上表面，压盖盖在压板上可防止采血针从采血针定位套筒中弹出；The top of the pressure plate is provided with a pressure cover, one end of the pressure cover is hinged with one end of the pressure plate, the other end of the pressure cover is just buckled on the upper surface of the other end of the pressure plate, and the pressure cover is covered on the pressure plate to prevent the blood collection needle from being positioned from the blood collection needle. ejected from the sleeve; 所述压盖的上表面设有把手B，方便拉起压盖；The upper surface of the gland is provided with a handle B, which is convenient for pulling up the gland; 所述小鼠定位箱和箱盖均为不透光亚克力材质；The mouse positioning box and the box cover are made of opaque acrylic material; 一种实验用鼠尾静脉采血测定血糖的装置的使用方法为，使用前，先将采血针针头朝下放入采血针定位套筒中，采血针针头从圆形针孔中伸出；A method of using an experimental rat tail vein blood collection device for measuring blood sugar is as follows: before use, put the needle of the blood collection needle downward into the positioning sleeve of the blood collection needle, and the needle of the blood collection needle protrudes from the circular needle hole; 使用时，在底板上铺设垫料，将实验用鼠放置于底板上，打开箱盖，将实验用鼠放进小鼠定位箱内，然后将小鼠尾巴从合适位置的鼠尾伸出孔中穿出，并放置在凹槽上，完成后，左手固定住小鼠尾巴，右手压在压盖上下压采血针，使采血针扎破实验用鼠尾部尖端静脉，然后用右手持装有血糖试纸的血糖检测仪，待血液溢出后即用可进行血糖测量, 若第一次使用采血机构未成功采血，可用左手反复挤压采血针扎取部位，促使鼠尾血液溢出，再次测量。When in use, lay padding on the bottom plate, place the experimental rat on the bottom plate, open the box cover, put the experimental rat into the mouse positioning box, and then extend the mouse tail from the mouse tail in the appropriate position. Pass it out and place it on the groove. After completion, fix the mouse tail with the left hand, press the blood collection needle up and down with the right hand on the gland, so that the blood collection needle pierces the vein at the tip of the tail of the experimental rat, and then use the right hand to hold the blood glucose test strip. The blood glucose monitor can be used for blood glucose measurement after the blood overflows. If the blood collection mechanism fails to collect blood for the first time, the blood collection needle can be repeatedly squeezed with the left hand to puncture the site to cause the blood to overflow from the tail of the rat, and then measure again.
CN201910866130.6A 2019-09-09 2019-09-09 Device of blood glucose is surveyed with blood sampling of mouse tail vein for experiments Active CN110721002B (en)

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CN112690786A (en) * 2020-12-28 2021-04-23 复旦大学附属中山医院 Sugar tolerance test system and method thereof

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Publication number Priority date Publication date Assignee Title
US4396023A (en) * 1981-09-21 1983-08-02 Anderson Porter W Apparatus for obtaining blood samples from animals such as mice or rats
CN202637184U (en) * 2012-07-26 2013-01-02 黑河学院 Device for vein haemospasia and fixation of rat
CN204446167U (en) * 2015-01-14 2015-07-08 苏州大学 Mouse tail vein injection experimental provision
CN205198188U (en) * 2015-11-12 2016-05-04 中国农业科学院农业质量标准与检测技术研究所 Rattail vein experimental apparatus
CN205379384U (en) * 2016-01-19 2016-07-13 张晓光 Auxiliary device for caudal vein injection and blood sampling of mice
CN208709902U (en) * 2018-01-18 2019-04-09 上海市同济医院 A kind of mouse tail vein automatic blood sampler
CN110151195A (en) * 2018-04-13 2019-08-23 刘奉伟 A kind of clinical examination blood collection auxiliary device
CN109771075A (en) * 2019-02-27 2019-05-21 山东中医药大学附属医院 Mouse tail vein blood collection and injection device

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