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CN110694036A - A kind of dog patch with slow release function and preparation method thereof - Google Patents

A kind of dog patch with slow release function and preparation method thereof Download PDF

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CN110694036A
CN110694036A CN201910771431.0A CN201910771431A CN110694036A CN 110694036 A CN110694036 A CN 110694036A CN 201910771431 A CN201910771431 A CN 201910771431A CN 110694036 A CN110694036 A CN 110694036A
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parts
ointment
patch
prepared
drug
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黄培冬
邰先桃
应力
袁恺
张粲
廖映烨
马永刚
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Yunnan University of Traditional Chinese Medicine TCM
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Yunnan University of Traditional Chinese Medicine TCM
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Abstract

本发明公开一种具有缓释功能的三伏贴及其制备方法,包括药贴和药膏组成,药膏由中药活性物质、药膏基质、药物缓释剂组成,中药活性物质由以下重量份数的原料制成:炒芥子、醋延胡索、细辛、甘遂、仙灵脾、干姜、肉桂、丁香,姜汁。本发明利用上述配伍,添加药物缓释剂,使能在较长时间内持续释放中药活性成分,以达到长效作用。添加药物缓释剂后刺激小而且疗效持久,且安全。不需要频繁给药,可以减少次数,使血药浓度平稳,避免峰谷现象,有利于降低药物的毒副作用。同时可减少用药的总剂量,用最小剂量达到最大药效。使用凡士林作为药膏基质,携带中药活性物质能够透过皮肤进入血液循环,释放速度稳定,对使用者有持续、强有力的治疗效果。

Figure 201910771431

The invention discloses a dog patch with slow-release function and a preparation method thereof. Ingredients: Fried mustard seeds, vinegar Corydalis, Asarum, Gansui, Xianlingpi, dried ginger, cinnamon, cloves, ginger juice. The present invention utilizes the above-mentioned compatibility and adds a drug slow-release agent, so that the active ingredients of the traditional Chinese medicine can be continuously released for a long time, so as to achieve a long-term effect. After adding the drug sustained-release agent, the irritation is small and the effect is long-lasting, and it is safe. Frequent administration is not required, the frequency can be reduced, the blood drug concentration can be stabilized, the peak-valley phenomenon can be avoided, and the toxic and side effects of the drug can be reduced. At the same time, the total dose of the drug can be reduced, and the maximum effect can be achieved with the smallest dose. Using vaseline as the base of the ointment, the active substances of traditional Chinese medicine can enter the blood circulation through the skin, and the release rate is stable, which has a continuous and powerful therapeutic effect on the user.

Figure 201910771431

Description

一种具有缓释功能的三伏贴及其制备方法A kind of dog patch with slow release function and preparation method thereof

技术领域technical field

本发明涉及中药技术领域,具体涉及一种夏季养生三伏贴及其制备方法。The invention relates to the technical field of traditional Chinese medicines, in particular to a summer health-preserving dog fu stick and a preparation method thereof.

背景技术Background technique

“冬病夏治”疗法是我国传统中医药疗法中的特色疗法,它是根据《素问. 四气调神论》中“春夏养阳”的原则,结合天灸疗法,在人体的穴位上进行药物 敷贴,以鼓舞正气,增加抗病能力,从而达到防治疾病的目的。三伏天到来之际, 人体内阳气上升,经络通达,气血充沛,是温煦阳气、驱散内伏寒邪的最佳时机。 利用这一有利时机治疗某些寒性疾病,人体之阳气可充分得天阳之助,能最大限 度地祛除体内沉疴,调整人体阴阳平衡,使病情减轻、少发病甚至不发病。三伏 贴可疏通经络,调理气血,宽胸降气,健脾和胃,鼓舞阳气,调节人体的肺脾功 能,使机体的免疫功能不断增强,从而达到振奋阳气、促进血液循环、祛除寒邪、 增强抗病能力的效果。三伏贴能够有效帮助缓解儿童疾病,对于有慢性支气管炎、慢性咽炎、慢性鼻炎、反复感冒和支气管哮喘以及慢性腹泻、慢性胃炎、四肢不 温、畏寒、遗尿等症状或疾病有很好的治疗作用。三伏天是一年中最热、阳气最 盛、气温最高的阶段。此时贴几贴三伏贴可以帮助疏松人体腠理、促进经络气血 流通,是养生防病有效方法。"Summer treatment for winter diseases" is a characteristic therapy in traditional Chinese medicine in my country. It is based on the principle of "nourishing yang in spring and summer" in "Su Wen. Four Qi Regulating Theory", combined with moxibustion therapy, and is carried out on acupoints on the human body. Drug application to encourage uprightness, increase disease resistance, so as to achieve the purpose of disease prevention and treatment. When the dog days come, the yang qi in the human body rises, the meridians are accessible, and the qi and blood are abundant. It is the best time to warm the yang qi and dispel the inner cold evil. Taking advantage of this favorable opportunity to treat certain cold diseases, the yang qi of the human body can be fully aided by the heavenly yang, which can eliminate the scabies in the body to the greatest extent, and adjust the balance of yin and yang in the human body, so that the disease can be alleviated, less or even no disease. Sanfu paste can dredge the meridians, regulate qi and blood, widen the chest and lower qi, strengthen the spleen and stomach, encourage yang qi, regulate the function of the lungs and spleen of the human body, and continuously enhance the immune function of the body, thereby invigorating yang qi, promoting blood circulation, eliminating Cold evil, enhance the effect of disease resistance. Dog Fu Tie can effectively help relieve children's diseases. It is a good treatment for symptoms or diseases such as chronic bronchitis, chronic pharyngitis, chronic rhinitis, repeated colds and bronchial asthma, as well as chronic diarrhea, chronic gastritis, cold limbs, chills, enuresis and other symptoms. effect. Dog days are the hottest, most yang, and highest temperature stages of the year. At this time, sticking a few three-fu sticks can help loosen the body and promote the circulation of qi and blood in the meridians, which is an effective method for health preservation and disease prevention.

现阶段三伏贴及其使用方法是:将配伍好的中药打磨成100-120目的药粉后, 使用姜汁和蜂蜜调和后,制成一毛钱银币大小的药膏,这时用医用胶布或伤湿膏 贴敷。这样使用三伏贴,药膏有滑落的可能,同时这样的药膏会引起肌肤的不适, 引发皮肤病,再者药膏贴在身体上,药效释放过于集中,不利于药效的吸收。At this stage, the three-fu stick and its application method are as follows: after grinding the compatible traditional Chinese medicine into 100-120 mesh powder, mixing with ginger juice and honey to make an ointment the size of a dime silver coin, at this time, use medical tape or wound dampness Paste application. In this way, if the ointment is used in this way, the ointment may slip off. At the same time, such an ointment will cause discomfort to the skin and cause skin diseases. Furthermore, if the ointment is attached to the body, the release of the medicinal effect is too concentrated, which is not conducive to the absorption of the medicinal effect.

发明内容SUMMARY OF THE INVENTION

本发明的目的就是克服上述三伏贴的不足而全新的一种具有缓释功能的三 伏贴。一种具有缓释功能的三伏贴,其特征在于:包括药贴(1)和药膏(2)组 成,所述药膏(2)由中药活性物质、药膏基质、药物缓释剂组成。所述中药活 性物质由以下重量份数的原料制成:炒芥子20-40份、醋延胡索20-40份、细辛 10-15份、甘遂10-15份、仙灵脾15-25份、干姜20-30份、肉桂10-15份、丁香 10-15份,姜汁60-70份。The purpose of the present invention is to overcome the above-mentioned deficiencies of the three-fu paste and a brand-new three-fu paste with slow-release function. A dog patch with sustained-release function, characterized in that: it comprises a medicated patch (1) and an ointment (2), and the ointment (2) is made up of a traditional Chinese medicine active substance, an ointment base, and a drug sustained-release agent. The traditional Chinese medicine active substance is made from the following raw materials in parts by weight: 20-40 parts of fried mustard seeds, 20-40 parts of vinegar Corydalis fragrans, 10-15 parts of Asarum, 10-15 parts of kansui, and 15-25 parts of Xianlingpi , 20-30 parts of dried ginger, 10-15 parts of cinnamon, 10-15 parts of cloves, 60-70 parts of ginger juice.

所述药膏基质为凡士林。The ointment base is Vaseline.

所述药物缓释剂为聚维酮,能使药物缓慢释放,并在较长的一段时间内维持 药物的浓度保持在有效浓度。The drug sustained-release agent is povidone, which can slowly release the drug and maintain the concentration of the drug at an effective concentration for a long period of time.

每1000重量份的药膏中,含有175-265重量份的中药活性成分,含有732-824 重量份的药膏基质,含有1-3份药物缓释剂。Every 1000 parts by weight of the ointment contains 175-265 parts by weight of active ingredients of traditional Chinese medicine, 732-824 parts by weight of an ointment base, and 1-3 parts of drug sustained-release agents.

所述姜汁的制备方法为将新鲜生姜洗净,切片,榨汁,得到姜汁。The preparation method of the ginger juice is to wash the fresh ginger, slice it, and squeeze the juice to obtain the ginger juice.

所述药贴(1)的结构是由薄贴(3)、药膏固定环(4)、保护贴(5)组成, 所述薄贴(3)一面具有粘性,所述药膏固定环(4)位于具有粘性面的薄贴(3) 中部,保护贴(5)和具有粘性面的薄贴(3)相连接,将整张薄贴(3)及药膏 固定环(4)全部覆盖密封。The structure of the medicinal patch (1) is composed of a thin patch (3), an ointment fixing ring (4), and a protective sticker (5). The protective sticker (5) is connected to the thin sticker (3) with an adhesive surface, and the entire thin sticker (3) and the ointment fixing ring (4) are completely covered and sealed.

本发明的另一个目的是提供一种具有缓释功能的三伏贴的制备方法,其特征 在于,包括如下步骤:Another object of the present invention is to provide a kind of preparation method of the three voltaic patch with slow-release function, it is characterized in that, comprise the steps:

1、按照所述重量份数要求取原料炒芥子、醋延胡索、细辛、甘遂、仙灵脾、 干姜、肉桂、丁香、姜汁,以及药物缓释剂和药膏基质;1, according to the described parts by weight requirement, get raw material fried mustard seeds, vinegar Corydalis, Asarum, kansui, Xianlingpi, dried ginger, cinnamon, cloves, ginger juice, and drug slow-release agent and ointment base;

2、将炒芥子、醋延胡索、细辛、甘遂、仙灵脾、干姜、肉桂、丁香一起用 设备球磨机制成粉末,备用;2. Mix the fried mustard seeds, vinegar Corydalis, Asarum, Gansui, Xianlingpi, dried ginger, cinnamon, and cloves together with a ball mill to make powder, and set aside;

3、将步骤1准备好的姜汁调和步骤2制备的原料粉末,调和3-5分钟后, 使用干燥机干燥,备用;3. Blend the ginger juice prepared in step 1 with the raw material powder prepared in step 2, and after blending for 3-5 minutes, use a dryer to dry it for later use;

4、将步骤3制备好的中药活性成分,与步骤1准备好的药物缓释剂和药膏 基质混合,充分搅拌混合均匀后装管;4. Mix the active ingredients of traditional Chinese medicine prepared in step 3 with the drug slow-release agent and ointment base prepared in step 1, fully stir and mix evenly and then install into a tube;

5、将全部覆盖密封的药贴(1)与步骤4制备好的药膏(2)装盒,得成品 三伏贴。5. Pack the fully covered and sealed medicinal patch (1) and the medicinal ointment (2) prepared in step 4 into a box to obtain a finished Sanfu patch.

本发明中,炒芥子,取净芥子,照清炒法炒至深黄色有香辣气,制成炒芥子。 性温,味厚气锐。入肺、胃经。可利气豁痰,温中散寒,通络止痛。治疗痰饮咳 喘,胸胁胀满疼痛,反胃呕吐,中风不语,肢体痹痛麻木,脚气,阴疽,肿毒, 跌打肿痛。肺虚久咳及阴虚火旺者禁服。In the present invention, to fry mustard seeds, take net mustard seeds, and stir-fry them according to the stir-frying method until deep yellow and fragrant and spicy, to prepare fried mustard seeds. Warm in nature, thick and sharp in taste. Enter the lung and stomach meridians. It can benefit Qi and dispel phlegm, warm the middle and dispel cold, and relieve pain by dredging collaterals. Treatment of phlegm-drinking cough and asthma, fullness and pain in the chest and flanks, nausea and vomiting, apoplexy, numbness, numbness of limbs, beriberi, gangrene, swollen poison, swelling and pain from falls. People with lung deficiency and chronic cough and yin deficiency should not take it.

细辛,中药名,属马兜铃目,马兜铃科多年生草本;根状茎直立或横走,有 多条须根;叶通常2枚,叶片心形或卵状心形,花紫黑色;花梗长2~100px;花 被裂片三角状卵形,果近球状,直径约37.5px,棕黄色。花期4~5月。有祛风, 散寒,行水,开窍等功效。常用于风冷头痛,鼻渊,齿痛,痰饮咳逆,风湿痹痛 等。细辛既能外散风寒,又能内祛阴寒,同时止痛、镇咳功效较佳。Asarum, the name of Chinese medicine, belongs to Aristolochia, Aristolochiaceae perennial herb; rhizome is erect or horizontal, with many fibrous roots; leaves are usually 2, the leaves are heart-shaped or oval heart-shaped, and the flowers are purple-black; Pedicel is 2-100px long; perianth lobes are triangular-ovate, fruit nearly spherical, about 37.5px in diameter, brownish yellow. The flowering period is April to May. It has the functions of dispelling wind, dispelling cold, running water, and opening orifices. Commonly used for wind-cold headache, nasal congestion, toothache, phlegm-draining cough, rheumatic arthralgia, etc. Asarum can not only disperse wind-cold externally, but also dispel yin-cold internally, and at the same time, it has better analgesic and antitussive effects.

延胡索,中药名。性味:辛;苦;温;无毒。归经:入肝、胃、心经。功效 与作用:活血;行气;止痛。用于气血瘀滞诸痛证;本品辛散温通,“能行血中 气滞,气中血滞,故专治一身上下诸痛”,止痛作用强。常用于胸痹心痛、胃痛、 肝郁气滞胁肋胀痛、痛经、产后瘀滞腹痛、寒疝腹痛、跌打损伤、风湿痹痛等。 醋延胡索:取净延胡索,用醋拌匀,浸润,至醋吸尽,置锅内用文火炒至微干, 取出,放凉;或取净延胡索,加醋置锅内共煮,至醋吸净,烘干,取出,放凉。 醋制后可增强止痛的作用。Corydalis, Chinese medicine name. Nature and flavor: acrid; bitter; warm; non-toxic. Meridian: Enters the liver, stomach, and heart meridians. Efficacy and role: promoting blood circulation; promoting qi; relieving pain. It is used for all kinds of pain syndromes due to stagnation of qi and blood; this product is Xin San Wen Tong, "can promote qi stagnation in blood, and blood stagnation in qi, so it is specialized in treating all kinds of pain in the upper body and lower body", and has a strong analgesic effect. Commonly used for chest pain, stomach pain, liver qi stagnation, flank pain, dysmenorrhea, postpartum stasis abdominal pain, cold hernia abdominal pain, bruises, rheumatic arthralgia, etc. Vinegar Corydalis: Take clean Corydalis, mix well with vinegar, soak until the vinegar is exhausted, put it in a pot and fry it on low heat until it is slightly dry, take it out, and let it cool; Clean, dry, remove and let cool. Vinegar can enhance the pain relief effect.

干姜,中药名。为姜科植物姜的干燥根茎。冬季采挖,除去须根和泥沙,晒 干或低温干燥。趁鲜切片晒干或低温干燥者称为“干姜片”。温中散寒,回阳通脉, 温肺化饮。主治用于脘腹冷痛,呕吐泄泻,肢冷脉微,寒饮喘咳。Dried ginger, Chinese medicine name. It is the dried rhizome of the ginger plant Ginger. Excavate in winter, remove fibrous roots and sediment, and dry in the sun or at low temperature. Those sliced and dried in the sun or at low temperature are called "dried ginger slices". Warming the middle and dispelling cold, Huiyang and Tongmai, warming the lungs and transforming the drink. Indications are used for abdominal cold pain, vomiting and diarrhea, cold limbs and weak pulse, cold drink and cough.

肉桂为为樟科植物肉桂的干皮及枝皮,其主治补元阳,暖脾胃,除积冷,通 血脉。治命门火衰,肢冷脉微,亡阳虚脱,腹痛泄泻,寒疝奔豚,腰膝冷痛,经 闭癥瘕,阴疽,流注,及虚阳浮越,上热下寒。Cinnamon is the dry bark and branch bark of the Lauraceae plant, cinnamon, which is mainly used for nourishing Yuanyang, warming the spleen and stomach, removing cold accumulation, and dredging blood vessels. Treatment of fire failure in the door of life, cold limbs, weak pulse, depletion of yang, abdominal pain and diarrhea, cold hernia, cold pain in the waist and knees, amenorrhea, dysmenorrhea, yin gangrene, bleeding, and deficiency of yang, upper heat and lower cold .

丁香别名丁子香、鸡舌,其性温,味辛,归胃、脾、肾经。中医认为,丁香 的功效为温中、暖肾、降逆。可用于治疗打嗝和因消化不良引起的腹胀、腹泻、 呕吐、口臭等症。另外,丁香还有补肾阳的作用,可用来治疗因肾阳虚导致的阳 痿、早泄、腰部怕冷等症状。现代药理研究证实,丁香还具有如下一些保健作用, 丁香能抑制细菌及微生物滋长,可用于牙科口腔治疗中。公丁香适量,水煎漱口, 可以治疗牙疼、口腔溃疡、口臭等口腔问题,所以可以称为天然中药口香糖。丁 香具有健胃消胀、促进排气的功效,减轻因胃部发酵产生的呃逆、反胃与口气不 佳,缓和因拉肚子所引起的腹部疼痛。Cloves, also known as cloves, chicken tongue, are warm in nature and pungent in taste, and belong to the stomach, spleen and kidney meridians. Traditional Chinese medicine believes that cloves have the functions of warming the middle, warming the kidneys, and lowering the negative effects. It can be used to treat hiccups and bloating, diarrhea, vomiting, bad breath and other symptoms caused by indigestion. In addition, cloves also have the effect of tonifying kidney yang, which can be used to treat symptoms such as impotence, premature ejaculation, cold waist and other symptoms caused by kidney yang deficiency. Modern pharmacological studies have confirmed that cloves also have the following health care effects, cloves can inhibit the growth of bacteria and microorganisms, and can be used in dental and oral treatment. The right amount of cloves, decoction and gargle, can treat oral problems such as toothache, oral ulcers, bad breath, etc., so it can be called natural traditional Chinese medicine chewing gum. Cloves have the effect of invigorating the stomach, reducing bloating, promoting exhaust, reducing hiccups, nausea and bad breath caused by stomach fermentation, and alleviating abdominal pain caused by diarrhea.

本发明利用上述配伍,添加药物缓释剂,使能在较长时间内持续释放中药活 性成分,以达到长效作用。添加药物缓释剂后刺激小而且疗效持久,且安全。不 需要频繁给药,可以减少次数,使血药浓度平稳,避免峰谷现象,有利于降低药 物的毒副作用。同时可减少用药的总剂量,用最小剂量达到最大药效。The present invention utilizes the above-mentioned compatibility and adds a drug sustained-release agent, so that the active ingredient of the traditional Chinese medicine can be continuously released in a relatively long period of time, so as to achieve a long-acting effect. After adding the drug sustained-release agent, the irritation is small and the effect is long-lasting, and it is safe. Frequent administration is not required, the frequency can be reduced, the blood drug concentration can be stabilized, the peak-to-valley phenomenon can be avoided, and the toxic and side effects of the drug can be reduced. At the same time, the total dose of the drug can be reduced, and the maximum effect can be achieved with the smallest dose.

本方中,干姜、肉桂性味均未辛热为君药,臣药为甘遂、仙灵脾、炒芥子、 醋延胡索,佐药为细辛、丁香,使药为姜汁。In this recipe, dried ginger and cinnamon are neither spicy nor hot in nature and taste as the king medicine, the minister medicine is kansui, Xianlingpi, fried mustard seeds, vinegar Corydalis, the adjuvant is asarum, clove, and the medicine is ginger juice.

使用凡士林作为药膏基质,相比之前使用蜂蜜调和后涂抹于使用者平复上, 本发明粘度小、性质稳定,凡士林携带中药活性物质能够透过皮肤进入血液循环, 释放速度稳定,对使用者有持续、强有力的治疗效果。Using vaseline as the base of the ointment, compared with the previous use of honey to reconcile and spread it on the user's calm, the present invention has low viscosity and stable properties. , powerful therapeutic effect.

附图说明Description of drawings

图1是本发明的结构示意图;Fig. 1 is the structural representation of the present invention;

图2是本发明的侧视结构示意图。Figure 2 is a schematic side view of the structure of the present invention.

1是药贴,2是药膏,3是薄贴,4是药膏固定环,5是保护贴。1 is the medicine patch, 2 is the ointment, 3 is the thin patch, 4 is the ointment fixing ring, and 5 is the protective sticker.

具体实施方式Detailed ways

实施例1Example 1

本发明的目的就是克服上述三伏贴的不足而全新的一种具有缓释功能的三 伏贴,其特征在于:包括药贴1和药膏2组成,药膏2由中药活性物质、药膏基 质凡士林、药物缓释剂聚维酮组成。所述中药活性物质由以下重量份数的原料制 成:每1000重量份的药膏中,炒芥子20份、醋延胡索20份、细辛10份、甘遂 10份、仙灵脾15份、干姜20份、肉桂10份、丁香10份,姜汁60份。The object of the present invention is to overcome the deficiencies of above-mentioned dog plaster and a brand-new kind of dog plaster with slow-release function, it is characterized in that: comprise medicated patch 1 and ointment 2 to form, ointment 2 is made up of traditional Chinese medicine active substance, ointment base vaseline, medicine slow The release agent is composed of povidone. Described traditional Chinese medicine active material is made up of the following raw materials by weight: in every 1000 parts by weight of ointment, 20 parts of fried mustard seeds, 20 parts of vinegar Corydalis, 10 parts of asarum, 10 parts of kansui, 15 parts of celestial spleen, dry 20 parts ginger, 10 parts cinnamon, 10 parts cloves, 60 parts ginger juice.

含有824重量份的药膏基质,含有1份药物缓释剂。Contains 824 parts by weight of ointment base and 1 part of drug sustained release agent.

药贴1的结构是由薄贴3、药膏固定环4、保护贴5组成,薄贴3一面具有 粘性,所述药膏固定环4位于具有粘性面的薄贴3中部,保护贴5和具有粘性面 的薄贴3相连接,将整张薄贴3及药膏固定环4全部覆盖密封。The structure of the medicated patch 1 is composed of a thin sticker 3, an ointment fixing ring 4, and a protective sticker 5. One side of the thin sticker 3 is sticky, and the ointment fixing ring 4 is located in the middle of the thin sticker 3 with a sticky surface. The thin stickers 3 on the surface are connected, and the entire thin sticker 3 and the ointment fixing ring 4 are completely covered and sealed.

本发明的另一个目的是提供一种具有缓释功能的三伏贴的制备方法,其特征 在于,包括如下步骤:Another object of the present invention is to provide a kind of preparation method of the three voltaic patch with slow-release function, it is characterized in that, comprise the steps:

1、按照所述重量份数要求取原料炒芥子、醋延胡索、细辛、甘遂、仙灵脾、 干姜、肉桂、丁香、姜汁,以及凡士林和聚维酮;1, get raw material fried mustard seeds, vinegar Corydalis fragrans, asarum, kansui, Xianlingpi, dried ginger, cinnamon, cloves, ginger juice, and vaseline and povidone according to the described parts by weight requirements;

2、将炒芥子、醋延胡索、细辛、甘遂、仙灵脾、干姜、肉桂、丁香一起用 设备球磨机制成粉末,备用;2. Mix the fried mustard seeds, vinegar Corydalis, Asarum, Gansui, Xianlingpi, dried ginger, cinnamon, and cloves together with a ball mill to make powder, and set aside;

3、将步骤1准备好的姜汁调和步骤2制备的原料粉末,调和5分钟后,使 用干燥机干燥,备用;3. The ginger juice prepared in step 1 is reconciled with the raw material powder prepared in step 2, and after reconciling for 5 minutes, use a drier to dry for subsequent use;

4、将步骤3制备好的中药活性成分,与步骤1准备好的药物缓释剂和药膏 基质混合,充分搅拌混合均匀后装管;4. Mix the active ingredients of traditional Chinese medicine prepared in step 3 with the drug slow-release agent and ointment base prepared in step 1, fully stir and mix evenly and then install into a tube;

5、将全部覆盖密封的药贴(1)与步骤4制备好的药膏(2)装盒,得成品 三伏贴。5. Pack the fully covered and sealed medicinal patch (1) and the medicinal ointment (2) prepared in step 4 into a box to obtain a finished Sanfu patch.

实施例2Example 2

一种具有缓释功能的三伏贴,其特征在于:包括药贴1和药膏2组成,药膏 2由中药活性物质、药膏基质凡士林、药物缓释剂聚维酮组成。中药活性物质由 以下重量份数的原料制成:炒芥子40份、醋延胡索40份、细辛15份、甘遂15 份、仙灵脾25份、干姜30份、肉桂15份、丁香15份,姜汁70份。A dog patch with slow-release function is characterized in that: it comprises a medicinal patch 1 and an ointment 2, and the ointment 2 is composed of a traditional Chinese medicine active substance, an ointment base vaseline, and a drug slow-release agent povidone. The traditional Chinese medicine active substance is made from the following raw materials by weight: 40 parts of fried mustard seeds, 40 parts of vinegar Corydalis, 15 parts of Asarum, 15 parts of kansui, 25 parts of Xianlingpi, 30 parts of dried ginger, 15 parts of cinnamon, 15 parts of cloves 70 servings of ginger juice.

每1000重量份的药膏中,含有732重量份的药膏基质,含有3份药物缓释 剂。Every 1000 parts by weight of the ointment contains 732 parts by weight of the ointment base and 3 parts of drug sustained-release agents.

药贴1的结构是由薄贴3、药膏固定环4、保护贴5组成,薄贴3一面具有 粘性,所述药膏固定环4位于具有粘性面的薄贴3中部,保护贴5和具有粘性面 的薄贴3相连接,将整张薄贴3及药膏固定环4全部覆盖密封。The structure of the medicated patch 1 is composed of a thin sticker 3, an ointment fixing ring 4, and a protective sticker 5. One side of the thin sticker 3 is sticky, and the ointment fixing ring 4 is located in the middle of the thin sticker 3 with a sticky surface. The thin stickers 3 on the surface are connected, and the entire thin sticker 3 and the ointment fixing ring 4 are completely covered and sealed.

本发明的另一个目的是提供一种具有缓释功能的三伏贴的制备方法,其特征 在于,包括如下步骤:Another object of the present invention is to provide a kind of preparation method of the three voltaic patch with slow-release function, it is characterized in that, comprise the steps:

1、按照所述重量份数要求取原料炒芥子、醋延胡索、细辛、甘遂、仙灵脾、 干姜、肉桂、丁香、姜汁,以及药物缓释剂和药膏基质;1, according to the described parts by weight requirement, get raw material fried mustard seeds, vinegar Corydalis, Asarum, kansui, Xianlingpi, dried ginger, cinnamon, cloves, ginger juice, and drug slow-release agent and ointment base;

2、将炒芥子、醋延胡索、细辛、甘遂、仙灵脾、干姜、肉桂、丁香一起用 设备球磨机制成粉末,备用;2. Mix the fried mustard seeds, vinegar Corydalis, Asarum, Gansui, Xianlingpi, dried ginger, cinnamon, and cloves together with a ball mill to make powder, and set aside;

3、将步骤1准备好的姜汁调和步骤2制备的原料粉末,调和3分钟后,使 用干燥机干燥,备用;3. The ginger juice prepared in step 1 is blended with the raw material powder prepared in step 2, and after blending for 3 minutes, use a dryer to dry for use;

4、将步骤3制备好的中药活性成分,与步骤1准备好的药物缓释剂和药膏 基质混合,充分搅拌混合均匀后装管;4. Mix the active ingredients of traditional Chinese medicine prepared in step 3 with the drug slow-release agent and ointment base prepared in step 1, fully stir and mix evenly and then install into a tube;

5、将全部覆盖密封的药贴1与步骤4制备好的药膏2装盒没记得成品三伏 贴。5. Pack the fully covered and sealed medicated patch 1 and the medicated ointment 2 prepared in step 4 into a box. I don't remember the finished product.

实施例3Example 3

一种具有缓释功能的三伏贴,其特征在于:包括药贴1和药膏2组成,药膏 2由中药活性物质、药膏基质凡士林、药物缓释剂聚维酮组成。所述中药活性物 质由以下重量份数的原料制成:炒芥子30份、醋延胡索28份、细辛13份、甘 遂13份、仙灵脾20份、干姜22份、肉桂13份、丁香11份,姜汁62份。A dog patch with slow-release function is characterized in that: it comprises a medicinal patch 1 and an ointment 2, and the ointment 2 is composed of a traditional Chinese medicine active substance, an ointment base vaseline, and a drug slow-release agent povidone. Described traditional Chinese medicine active substance is made up of the following raw materials by weight: 30 parts of fried mustard seeds, 28 parts of vinegar Corydalis fragrans, 13 parts of Asarum, 13 parts of kansui, 20 parts of fairy spirit spleen, 22 parts of dried ginger, 13 parts of cinnamon, 11 cloves, 62 ginger juice.

每1000重量份的药膏中,含有786重量份的药膏基质,含有2份药物缓释 剂。In every 1000 parts by weight of the ointment, 786 parts by weight of the ointment base and 2 parts of drug sustained-release agents are contained.

药贴1的结构是由薄贴3、药膏固定环4、保护贴5组成,薄贴3一面具有 粘性,药膏固定环4位于具有粘性面的薄贴3中部,保护贴5和具有粘性面的薄 贴3相连接,将整张薄贴3及药膏固定环4全部覆盖密封。The structure of the medicated sticker 1 is composed of a thin sticker 3, an ointment fixing ring 4, and a protective sticker 5. One side of the thin sticker 3 is sticky, and the ointment fixing ring 4 is located in the middle of the thin sticker 3 with a sticky surface. The thin stickers 3 are connected, and the entire thin sticker 3 and the ointment fixing ring 4 are completely covered and sealed.

本发明的另一个目的是提供一种具有缓释功能的三伏贴的制备方法,其特征 在于,包括如下步骤:Another object of the present invention is to provide a kind of preparation method of the three voltaic patch with slow-release function, it is characterized in that, comprise the steps:

1、按照所述重量份数要求取原料炒芥子、醋延胡索、细辛、干姜、肉桂、 丁香、姜汁,以及药物缓释剂和药膏基质;1, according to the described parts by weight requirements, get raw material fried mustard seeds, vinegar Corydalis, Asarum, dried ginger, cinnamon, cloves, ginger juice, and drug slow-release agent and ointment base;

2、将炒芥子、醋延胡索、细辛、甘遂、仙灵脾、干姜、肉桂、丁香一起用 设备球磨机制成粉末,备用;2. Mix the fried mustard seeds, vinegar Corydalis, Asarum, Gansui, Xianlingpi, dried ginger, cinnamon, and cloves together with a ball mill to make powder, and set aside;

3、将步骤1准备好的姜汁调和步骤2制备的原料粉末,调和3-5分钟后, 使用干燥机干燥,备用;3. Blend the ginger juice prepared in step 1 with the raw material powder prepared in step 2, and after blending for 3-5 minutes, use a dryer to dry it for later use;

4、将步骤3制备好的中药活性成分,与步骤1准备好的药物缓释剂和药膏 基质混合,充分搅拌混合均匀后装管;4. Mix the active ingredients of traditional Chinese medicine prepared in step 3 with the drug slow-release agent and ointment base prepared in step 1, fully stir and mix evenly and then install into a tube;

5、将全部覆盖密封的药贴1与步骤4制备好的药膏2装盒,得成品三伏贴。5. Pack the fully covered and sealed medicinal patch 1 and the medicinal ointment 2 prepared in step 4 into a box to obtain the finished dog patch.

使用方法Instructions

本发明将药膏和药贴配合一同使用,首先,将装盒的三伏贴中的药膏和药贴 取出,其次将装管的药膏涂抹于穴位上,涂抹均匀;最后,将保护贴揭开,将药 膏固定环4放置于涂抹药膏的地方,固定好涂抹区域,将薄贴3固定于使用者皮 肤上。The present invention uses the ointment and the medicated patch together. First, take out the ointment and the medicated patch in the boxed dog ointment, secondly apply the tubed ointment on the acupoints, and apply evenly; The ointment fixing ring 4 is placed at the place where the ointment is applied, the application area is fixed, and the thin patch 3 is fixed on the user's skin.

使用注意事项Precautions for use

1、对贴敷有效成分过敏者禁止使用1. Those who are allergic to the active ingredients of the patch are forbidden to use

2、怀孕、哺乳期产妇禁止使用2. Pregnant and lactating women are prohibited from using

3、对贴敷的添加剂过敏者禁止使用3. Those who are allergic to the applied additives are forbidden to use

Claims (7)

1. A kind of three-volt paste with slow release function, characterized by that: the Sanfu plaster can be an ointment (2) and a medicinal plaster (1), wherein the Sanfu plaster (2) consists of traditional Chinese medicine active substances, an ointment matrix and a medicine slow-release agent, and the traditional Chinese medicine active substances are prepared from the following raw materials in parts by weight: 20-40 parts of fried mustard seed, 20-40 parts of vinegar rhizoma corydalis, 10-15 parts of asarum, 10-15 parts of euphorbia kansui, 15-25 parts of epimedium, 20-30 parts of dried ginger, 10-15 parts of cinnamon, 10-15 parts of clove and 60-70 parts of ginger juice.
2. The patch according to claim 1, wherein the patch has a slow release function, and is characterized in that: the ointment matrix is vaseline.
3. The patch according to claim 1, wherein the patch has a slow release function, and is characterized in that: the drug sustained release agent is povidone.
4. The patch according to claim 1, wherein the patch has a slow release function, and is characterized in that: each 1000 parts by weight of the ointment contains 150-225 parts by weight of traditional Chinese medicine active substances, 772-849 parts by weight of ointment matrix and 1-3 parts by weight of drug sustained-release agent.
5. A kind of three-volt paste with slow release function, characterized by that: three lie prostrate subsides medicine (1) structure by thin subsides (3), the solid fixed ring of ointment (4), protection subsides (5) constitute according to the preface, wherein thin subsides (3) one side has viscidity, the solid fixed ring of ointment (4) are located thin subsides (3) middle part that has the viscidity face, and protection subsides (5) are connected with thin subsides (3) that have the viscidity face, and protection subsides (5) are all covered sealed whole thin subsides (3) and the solid fixed ring of ointment (4).
6. A preparation method of a patch with a slow release function is characterized by comprising the following steps:
(1) taking the raw materials of stir-fried mustard seed, vinegar rhizoma corydalis, asarum, dried ginger, cinnamon, clove and ginger juice as well as a drug sustained-release agent and an ointment matrix according to the requirements of the parts by weight;
(2) pulverizing parched semen Brassicae Junceae, rhizoma corydalis processed with vinegar, herba asari, radix kansui, herba Epimedii, Zingiberis rhizoma, cortex Cinnamomi, and flos Caryophylli with ball mill;
(3) blending the ginger juice prepared in the step (1) with the raw material powder prepared in the step (2) for 3-5 minutes, and drying by using a dryer for later use;
(4) mixing the traditional Chinese medicine active ingredients prepared in the step (3) with the medicine sustained-release agent and the ointment matrix prepared in the step (1), fully stirring and uniformly mixing to obtain an ointment (2), and filling the ointment (2) into a tube;
(5) and (4) boxing the completely covered and sealed medicine patch (1) and the prepared ointment (2) in the step (4) to obtain the finished product of the sanfu patch.
7. The patch according to claim 1, wherein the patch has a slow release function, and is characterized in that: the ginger juice is prepared by cleaning fresh ginger, slicing and squeezing.
CN201910771431.0A 2019-08-21 2019-08-21 A kind of dog patch with slow release function and preparation method thereof Pending CN110694036A (en)

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