[go: up one dir, main page]

CN1192765C - 紫杉醇制剂 - Google Patents

紫杉醇制剂 Download PDF

Info

Publication number
CN1192765C
CN1192765C CNB00814706XA CN00814706A CN1192765C CN 1192765 C CN1192765 C CN 1192765C CN B00814706X A CNB00814706X A CN B00814706XA CN 00814706 A CN00814706 A CN 00814706A CN 1192765 C CN1192765 C CN 1192765C
Authority
CN
China
Prior art keywords
paclitaxel
solubilizing agent
compositions
acid
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB00814706XA
Other languages
English (en)
Chinese (zh)
Other versions
CN1382038A (zh
Inventor
R·乔希
A·Y·戈尔
J·鲁宾菲尔德
R·施罗特里亚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astex Pharmaceuticals Inc
Original Assignee
Supergen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Supergen Inc filed Critical Supergen Inc
Publication of CN1382038A publication Critical patent/CN1382038A/zh
Application granted granted Critical
Publication of CN1192765C publication Critical patent/CN1192765C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CNB00814706XA 1999-10-25 2000-09-14 紫杉醇制剂 Expired - Fee Related CN1192765C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/427,153 US6136846A (en) 1999-10-25 1999-10-25 Formulation for paclitaxel
US09/427,153 1999-10-25

Publications (2)

Publication Number Publication Date
CN1382038A CN1382038A (zh) 2002-11-27
CN1192765C true CN1192765C (zh) 2005-03-16

Family

ID=23693701

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB00814706XA Expired - Fee Related CN1192765C (zh) 1999-10-25 2000-09-14 紫杉醇制剂

Country Status (7)

Country Link
US (4) US6136846A (fr)
EP (1) EP1225872A1 (fr)
JP (1) JP2003512416A (fr)
CN (1) CN1192765C (fr)
AU (1) AU7490200A (fr)
CA (1) CA2388613A1 (fr)
WO (1) WO2001030319A1 (fr)

Families Citing this family (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245805B1 (en) * 1995-10-26 2001-06-12 Baker Norton Pharmaceuticals, Inc. Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
US20030087954A1 (en) * 1997-01-07 2003-05-08 Sonus Pharmaceuticals, Inc. Method of treating bladder carcinoma using a Taxane/Tocopherol formulation
US6727280B2 (en) * 1997-01-07 2004-04-27 Sonus Pharmaceuticals, Inc. Method for treating colorectal carcinoma using a taxane/tocopherol formulation
US6458373B1 (en) * 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US20030105156A1 (en) * 1997-01-07 2003-06-05 Nagesh Palepu Method for administration of a taxane/tocopherol formulation to enhance taxane therapeutic utility
US6136846A (en) * 1999-10-25 2000-10-24 Supergen, Inc. Formulation for paclitaxel
US6828346B2 (en) * 1999-10-25 2004-12-07 Supergen, Inc. Methods for administration of paclitaxel
AU2001228454A1 (en) * 2000-01-13 2001-07-24 Merck Patent G.M.B.H Pharmaceutical preparations containing 2-pyrrolidone as the dissolving intermediary
CA2404374A1 (fr) * 2000-03-24 2001-10-04 Baker Norton Pharmaceuticals, Inc. Utilisation de sels metalliques pour stabiliser des compositions a base de taxane
AU770436B2 (en) * 2000-09-22 2004-02-19 Unilever Plc Use of prenylated flavones
US6919370B2 (en) * 2000-11-28 2005-07-19 Transform Pharmaceuticals, Inc. Pharmaceutical formulations comprising paclitaxel, derivatives, and pharmaceutically acceptable salts thereof
WO2002064132A2 (fr) * 2001-01-18 2002-08-22 Pharmacia & Upjohn Company Preparations de microemulsion chimiotherapeutique de paclitaxel presentant une meilleure biodisponibilite orale
US7115565B2 (en) 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
DK1392254T3 (da) * 2001-04-20 2007-07-02 Univ British Columbia Micelle-lægemiddelindgivelsessystem for hydrofobe lægemidler
CN1268321C (zh) * 2001-07-13 2006-08-09 那野伽利阿株式会社 内部包有药物的高分子胶束的冻结干燥用组合物和该胶束的制备方法
US6858227B1 (en) 2001-11-21 2005-02-22 Sonus Pharmaceuticals, Inc. Vitamin E conjugates
US20040092428A1 (en) * 2001-11-27 2004-05-13 Hongming Chen Oral pharmaceuticals formulation comprising paclitaxel, derivatives and methods of administration thereof
US7488313B2 (en) * 2001-11-29 2009-02-10 Boston Scientific Scimed, Inc. Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment
US20060078618A1 (en) * 2001-12-11 2006-04-13 Constantinides Panayiotis P Lipid particles and suspensions and uses thereof
JP2006501134A (ja) * 2001-12-20 2006-01-12 ブリストル−マイヤーズ　スクイブ　カンパニー 高い生物学的利用能を有する、経口活性タキサン誘導体の医薬組成物
WO2003103582A2 (fr) * 2002-06-05 2003-12-18 Ivax Corporation Reduction de la reticulation de gelatine
WO2004050068A1 (fr) * 2002-11-29 2004-06-17 Janssen Pharmaceutica N.V. Compositions pharmaceutiques comprenant un compose medicamenteux respectivement basique, tensioactif et base respectivement acide hydrosoluble et tolerable physiologiquement
US20040127551A1 (en) * 2002-12-27 2004-07-01 Kai Zhang Taxane-based compositions and methods of use
DK1583562T3 (da) 2003-01-06 2011-09-19 Angiochem Inc Angiopep-1, beslægtede forbindelser og anvendelser deraf
EP1498120A1 (fr) * 2003-07-18 2005-01-19 Aventis Pharma S.A. Formulation semi-solide pour l'administration orale du taxol
EP1510206A1 (fr) * 2003-08-29 2005-03-02 Novagali Pharma SA Formulation huileuse auto-émulsifiable pour l'administration de principes actifs peu solubles dans l'eau
DE602004014624D1 (de) * 2003-08-29 2008-08-07 Yissum Res Dev Co Selbst-nanoemulgierende ölige formulierung zur verabreichung von schwer wasserlöslichen arzneimitteln
DE602004027936D1 (de) * 2003-10-29 2010-08-12 Sonus Pharmaceutical Inc Tocopherolmodifizierte therapeutische arzneimittelverbindung
US20080045559A1 (en) * 2003-10-29 2008-02-21 Sonus Pharmaceuticals, Inc. Tocopherol-modified therapeutic drug compounds
US20050096365A1 (en) * 2003-11-03 2005-05-05 David Fikstad Pharmaceutical compositions with synchronized solubilizer release
US20070238098A1 (en) * 2003-11-05 2007-10-11 Yoshio Miki Method and Kit for Predicting Adverse Side Effects of Paclitaxel Therapy
TWI262798B (en) * 2003-12-31 2006-10-01 Ind Tech Res Inst Liposome and drug deliver system
US7989490B2 (en) 2004-06-02 2011-08-02 Cordis Corporation Injectable formulations of taxanes for cad treatment
US8003122B2 (en) * 2004-03-31 2011-08-23 Cordis Corporation Device for local and/or regional delivery employing liquid formulations of therapeutic agents
US7345093B2 (en) * 2004-04-27 2008-03-18 Formatech, Inc. Methods of enhancing solubility of compounds
WO2005105041A2 (fr) * 2004-04-27 2005-11-10 Formatech, Inc. Procedes permettant d'accroitre la solubilite d'agents
US7659310B2 (en) * 2004-04-27 2010-02-09 Formatech, Inc. Methods of enhancing solubility of agents
US7871632B2 (en) * 2004-07-12 2011-01-18 Adventrx Pharmaceuticals, Inc. Compositions for delivering highly water soluble drugs
US8557861B2 (en) * 2004-09-28 2013-10-15 Mast Therapeutics, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
GB0501192D0 (en) * 2005-01-20 2005-03-02 Resolution Chemicals Ltd Stable prostaglandin-containing compositions
US20060188543A1 (en) * 2005-01-31 2006-08-24 Si-Shen Feng Nanoparticle coating for drug delivery
BRPI0520032A2 (pt) 2005-02-18 2009-04-14 Angiochem Inc moléculas para transportar um composto através da barreira hematoencefálica
US20060287301A1 (en) * 2005-06-17 2006-12-21 Mcnair Douglas Novel formulations for phenothiazines, including fluphenazine and its derivatives
DK2233156T3 (da) 2005-07-15 2013-08-05 Angiochem Inc Anvendelse af aprotininpolypeptider som bærere i farmaceutiske konjugater
DE602006013893D1 (de) 2005-12-05 2010-06-02 Nitto Denko Corp Polyglutamat-Aminosäure-Konjugate und Verfahren
TWI376239B (en) * 2006-02-01 2012-11-11 Andrew Xian Chen Vitamin e succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
CN101011355B (zh) * 2006-02-01 2013-01-02 陈献 经维生素e琥珀酸酯稳定的医药组合物、其制备及用途
WO2007134354A1 (fr) * 2006-05-23 2007-11-29 Ebewe Pharma Ges.M.B.H. Nfg. Kg Formulation pharmaceutique
EP2338488A1 (fr) * 2006-05-26 2011-06-29 Bayer HealthCare, LLC Associations de médicaments comportant des urées de diaryle
EP2057117A2 (fr) 2006-08-21 2009-05-13 Synta Pharmaceuticals Corporation Composés servant à traiter des troubles prolifératifs
EP2359825A2 (fr) * 2006-10-06 2011-08-24 Takeda Pharmaceutical Company Limited Médicament en combinaison
AU2008210290B2 (en) * 2007-02-01 2013-10-31 National Research Council Of Canada Formulations of lipophilic bioactive molecules
EP2155255B1 (fr) 2007-05-09 2013-08-14 Nitto Denko Corporation Compositions comprenant un composé hydrophobe et un conjugué polyamino acide
JP2010528122A (ja) * 2007-05-09 2010-08-19 日東電工株式会社 白金薬剤と結合されたポリマー
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
AU2008269179A1 (en) * 2007-06-22 2008-12-31 Scidose Llc Solubilized formulation of docetaxel without Tween 80
ES2647538T3 (es) 2007-09-28 2017-12-22 Pfizer Inc. Direccionamiento a células de cáncer usando nanopartículas
CN101396354B (zh) * 2007-09-30 2010-12-01 江苏恒瑞医药股份有限公司 一种稳定的塔三烷类化合物液体组合物及其制备方法和其应用
WO2009064374A2 (fr) * 2007-11-09 2009-05-22 Synta Pharmaceuticals Corp. Formulations orales de bis(thiohydrazideamides)
EP2222278B1 (fr) * 2007-11-28 2015-04-08 Celator Pharmaceuticals, Inc. Système d'administration de taxane amélioré
EP2077132A1 (fr) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispositif distributeur, dispositif de stockage et procédé pour la distribution d'une formulation
EP2252269A1 (fr) * 2008-02-11 2010-11-24 Technion Research and Development Foundation, Ltd. Particules de caséine encapsulant des agents thérapeutiquement actifs et leurs utilisations
CN107088227A (zh) * 2008-03-28 2017-08-25 粒子科学有限公司 用于使治疗剂增溶的药物溶液和方法
US8420110B2 (en) * 2008-03-31 2013-04-16 Cordis Corporation Drug coated expandable devices
US8409601B2 (en) 2008-03-31 2013-04-02 Cordis Corporation Rapamycin coated expandable devices
AU2009238187B2 (en) * 2008-04-18 2014-03-06 Angiochem Inc. Pharmaceutical compositions of paclitaxel, paclitaxel analogs or paclitaxel conjugates and related methods of preparation and use
US8206747B2 (en) 2008-06-16 2012-06-26 Bind Biosciences, Inc. Drug loaded polymeric nanoparticles and methods of making and using same
WO2010005725A2 (fr) 2008-06-16 2010-01-14 Bind Biosciences, Inc. Nanoparticules polymères thérapeutiques comprenant des alcaloïdes vinca et procédés de fabrication et d’utilisation associés
US8613951B2 (en) 2008-06-16 2013-12-24 Bind Therapeutics, Inc. Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same
CA2740316A1 (fr) 2008-10-15 2010-04-22 Angiochem Inc. Conjugues d'agonistes de glp-1 et leurs utilisations
CA2745524C (fr) 2008-12-05 2020-06-09 Angiochem Inc. Conjugues de neurotensine ou d'analogues de neurotensine et leurs applications
US8563041B2 (en) * 2008-12-12 2013-10-22 Bind Therapeutics, Inc. Therapeutic particles suitable for parenteral administration and methods of making and using same
ES2776126T3 (es) 2008-12-15 2020-07-29 Pfizer Nanopartículas de circulación prolongada para la liberación sostenida de agentes terapéuticos
BRPI0922611A2 (pt) 2008-12-17 2018-11-06 Angiochem Inc inibidores de metaloproteína de matriz de membrana tipo 1 e usos dos mesmos
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US9173891B2 (en) 2009-04-20 2015-11-03 Angiochem, Inc. Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog
EP3508239B1 (fr) 2009-05-18 2020-12-23 Boehringer Ingelheim International GmbH Adaptateur, dispositif d'inhalation et pulvérisateur
EP2448965A4 (fr) 2009-07-02 2015-02-11 Angiochem Inc Conjugués peptidiques multimères et leurs utilisations
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
US20110070294A1 (en) * 2009-09-23 2011-03-24 Javeri Indu Methods for the Administration of Drugs Using Liposomes
US8591942B2 (en) 2009-09-23 2013-11-26 Indu JAVERI Methods for the preparation of liposomes comprising docetaxel
US7772274B1 (en) 2009-10-19 2010-08-10 Scidose, Llc Docetaxel formulations with lipoic acid
US8476310B2 (en) 2009-10-19 2013-07-02 Scidose Llc Docetaxel formulations with lipoic acid
US20110092579A1 (en) * 2009-10-19 2011-04-21 Scidose Llc Solubilized formulation of docetaxel
US8912228B2 (en) 2009-10-19 2014-12-16 Scidose Llc Docetaxel formulations with lipoic acid
US8541465B2 (en) * 2009-10-19 2013-09-24 Scidose, Llc Docetaxel formulations with lipoic acid and/or dihydrolipoic acid
US20120065255A1 (en) * 2009-10-19 2012-03-15 Nagesh Palepu Cabazitaxel formulations and methods of preparing thereof
CN102038634B (zh) * 2009-10-23 2014-12-10 天士力控股集团有限公司 一种含有助溶剂的紫杉烷类药物溶液及其制备方法
CN102038635A (zh) * 2009-10-23 2011-05-04 天津天士力集团有限公司 一种含有pH值调节剂的紫杉烷类药物溶液及其制备方法
CN102038636B (zh) * 2009-10-23 2014-08-13 天士力控股集团有限公司 一种含有螯合剂的紫杉烷类药物溶液及其制备方法
EA026241B1 (ru) 2009-11-25 2017-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Распылитель
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
JP5658268B2 (ja) 2009-11-25 2015-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
TR201906255T4 (tr) 2009-12-11 2019-05-21 Pfizer Terapötik partiküllerin liyofilize edilmesine yönelik stabil formülasyonlar.
JP5965844B2 (ja) 2009-12-15 2016-08-10 バインド セラピューティックス インコーポレイテッド 高いガラス転移温度または高分子量のコポリマーを有する治療用ポリマーナノ粒子組成物
MX341082B (es) 2010-05-03 2016-08-08 Teikoku Pharma Usa Inc Formulaciones de pro-emulsion de taxano no acuosas y metodos para hacer y usar las mismas.
JP5874724B2 (ja) 2010-06-24 2016-03-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
TWI472340B (zh) * 2010-11-10 2015-02-11 Tasly Holding Group Co Ltd Taxanes containing solution and a preparation method of the co-solvent
EP2694220B1 (fr) 2011-04-01 2020-05-06 Boehringer Ingelheim International GmbH Appareil médical pourvu d'un récipient
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
KR101832842B1 (ko) * 2012-01-13 2018-02-27 한미약품 주식회사 안정성이 향상된 에페리손 또는 이의 약학적으로 허용 가능한 염 및 특정 산성화제를 포함하는 약학 조성물
WO2013119864A1 (fr) 2012-02-07 2013-08-15 University Of Central Florida Research Foundation, Inc. Renforcement de la sensibilité au taxane de cellules cancéreuses
WO2013152894A1 (fr) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Pulvérisateur comprenant des moyens de détrompage
EP2679225A1 (fr) * 2012-06-26 2014-01-01 Universitätsklinikum Freiburg Composition pharmaceutique avec action synergétique d'inhibiteurs directs de la catalase et pour modulateurs du changement de matière NO entraînant une perturbation de la catalase ou de la production d'anions superoxydés extracellulaires
JP6356678B2 (ja) 2012-09-17 2018-07-11 ファイザー・インク 治療用ナノ粒子を製造する方法
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
ES2836977T3 (es) 2013-08-09 2021-06-28 Boehringer Ingelheim Int Nebulizador
EP3030298B1 (fr) 2013-08-09 2017-10-11 Boehringer Ingelheim International GmbH Nébuliseur
JP6528281B2 (ja) * 2014-01-29 2019-06-12 国立研究開発法人産業技術総合研究所 シクロデキストリンの利用による抗がん活性が増強されたアシュワガンダ葉の水抽出物の調製方法、及びアシュワガンダ葉を含む医薬組成物
BR112016021130A2 (pt) 2014-03-14 2017-08-15 Pfizer Nanopartículas terapêuticas, composição farmacêutica compreendendo as referidas nanopartículas, processo para a preparação e uso das mesmas
CA2943609A1 (fr) 2014-03-27 2015-10-01 The Brigham And Women's Hospital, Inc. Conjugues de medicaments actives metaboliquement pour vaincre la resistance dans une therapie du cancer
ES2874029T3 (es) 2014-05-07 2021-11-04 Boehringer Ingelheim Int Nebulizador
AU2015258107B2 (en) 2014-05-07 2019-12-19 Boehringer Ingelheim International Gmbh Nebulizer
WO2015169732A1 (fr) 2014-05-07 2015-11-12 Boehringer Ingelheim International Gmbh Contenant, nébuliseur et utilisation
DK3307326T3 (da) 2015-06-15 2020-10-19 Angiochem Inc Fremgangsmåder til behandling af leptomeningeal karcinomatose
TWI752750B (zh) 2015-09-30 2022-01-11 香港商慧源香港創新有限公司 口服紫杉烷組合物及方法
UA126402C2 (uk) 2017-06-09 2022-09-28 Екселіксіс, Інк. Рідка лікарська форма для лікування раку

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2086874E (fr) * 1992-08-03 2000-01-04 Renzo Mauro Canetta Methodes d'administration du taxol
TW406020B (en) * 1993-09-29 2000-09-21 Bristol Myers Squibb Co Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
US5681846A (en) * 1995-03-17 1997-10-28 Board Of Regents, The University Of Texas System Extended stability formulations for paclitaxel
US6964946B1 (en) * 1995-10-26 2005-11-15 Baker Norton Pharmaceuticals, Inc. Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same
US6458373B1 (en) * 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US5925776A (en) * 1997-12-24 1999-07-20 Schein Pharmacetical, Inc. Polyethoxylated castor oil, process of making the same and formulations thereof
IL131217A0 (en) * 1998-03-10 2001-01-28 Napro Biotherapeutics Inc Novel methods and compositions for delivery of taxanes
KR19990075621A (ko) * 1998-03-23 1999-10-15 임성주 경사 평판형 배양조
US5922754A (en) * 1998-10-02 1999-07-13 Abbott Laboratories Pharmaceutical compositions containing paclitaxel
US6017948A (en) * 1998-10-30 2000-01-25 Supergen, Inc. Water-miscible pharmaceutical compositions
JP2003500368A (ja) * 1999-05-24 2003-01-07 ソーナス ファーマシューティカルス，インコーポレイテッド 溶解度が不十分な薬剤のためのエマルジョンビヒクル
US6136846A (en) * 1999-10-25 2000-10-24 Supergen, Inc. Formulation for paclitaxel

Also Published As

Publication number Publication date
EP1225872A1 (fr) 2002-07-31
US6319943B1 (en) 2001-11-20
WO2001030319A1 (fr) 2001-05-03
JP2003512416A (ja) 2003-04-02
CN1382038A (zh) 2002-11-27
CA2388613A1 (fr) 2001-05-03
AU7490200A (en) 2001-05-08
US6538020B2 (en) 2003-03-25
US6509370B1 (en) 2003-01-21
US20020103254A1 (en) 2002-08-01
US6136846A (en) 2000-10-24

Similar Documents

Publication Publication Date Title
CN1192765C (zh) 紫杉醇制剂
CN1178655C (zh) 紫杉醇的与水混溶的药物组合物
CN113521002B (zh) 口服紫杉烷组合物和方法
HU217839B (hu) Eljárások taxánszármazékokat tartalmazó új stabil gyógyszerkészítmények előállítására
CN1555253A (zh) 化疗栓塞用紫杉醇的油性组合物、制剂及它们的制造方法
KR101542364B1 (ko) 탁산을 포함하는 경구 투여용 약학 조성물
US20140045927A1 (en) Preparations of taxanes for intravenous administration and the preparation method thereof
RU2398578C2 (ru) Фармацевтическая композиция, содержащая производное таксана, которая предназначена для приготовления инфузионного раствора, способ его приготовления и использование
EP3326628B1 (fr) Composition pharmaceutique pour l'administration par voie orale comprenant un taxane à haute concentration
JP2011529930A (ja) 注射可能タキサン医薬品組成物
CN1551771A (zh) 用于治疗癌症的方法和组合物
KR102401546B1 (ko) 탁산, 이의 약학적으로 허용되는 염, 또는 그의 수화물을 함유하는 안정성이 향상된 신규 약제학적 제형
CN1857221A (zh) 一种同载铂类化合物及其增效剂的抗癌缓释剂
CN1709236A (zh) 一种含有多西他赛的脂肪乳剂及其制备方法
KR101612259B1 (ko) 고농도의 탁산을 포함하는 경구 투여용 약학 조성물
JP6292267B2 (ja) ドセタキセル製剤
CN1846685A (zh) 含苯达莫司汀和其增效剂的缓释注射剂
CN101040852A (zh) 一种含铂类化合物及烷化剂的缓释注射剂
CN101040840A (zh) 一种含紫杉烷及磷酸肌醇3－激酶抑制剂的抗癌组合物
CN1973824A (zh) 同载铂类化合物和雷帕霉素的抗癌组合物
CN101040858A (zh) 一种含紫杉烷及烷化剂的抗癌组合物
CN101040859A (zh) 一种含抗癌药物及其增效剂的抗癌组合物
CZ300677B6 (cs) Farmaceutický prostredek s obsahem docetaxelu, urcený pro prípravu infúzního roztoku, zpusob jeho výroby a použití
CN1973819A (zh) 一种含抗癌药物及其增效剂的抗癌组合物
CN101040861A (zh) 一种含磷酸肌醇3－激酶抑制剂及烷化剂的抗癌组合物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee