CN1191743A - Medicine for diabetes - Google Patents

Abstract

Medicine for diabetes is one oral liquor designed based on the incidence mechanism of diabetes. Diabetes is caused mainly by exhaust dysfunction of small intestine, which prolongs the retention time of digested food in small intestine and results in excessive absorption of glucose. The present invention produces the oral liquor by using the Chinese herbal medicinal material rhubarb and licorice as main material, and the said medicine controles diabetes through promoting the normal composite digestion interspace motion.

Description

A kind of medicine for the treatment of diabetes

The present invention relates to a kind of medicine for the treatment of diabetes.

Non-insulin-dependent diabetes mellitus (hereinafter to be referred as diabetes) is a kind of commonly encountered diseases, frequently-occurring disease.Although science and technology development has reached suitable degree, still unclear to the cause of disease and the pathogeny of diabetes, treatment of diabetes is only limited to blood sugar control at present, and lack the radical-ability measure.

For a long time, people with diabetes be called be a kind of relevant with heredity, can control and the disease that cannot cure.Even now one conception of species is deep-rooted, but a kind of anything but disease directly related of diabetes with heredity.Just the opposite, it is a kind of disease that can cure relevant with social times.The key of capturing diabetes is to find its cause of disease and pathogeny.

Epidemiologic data shows that the sickness rate of diabetes is cumulative year after year trend, and this increasing progressively only occurred in for 20th century.In emerging industrial nations and developing country, change along with people life style, particularly life style westernization, its sickness rate is increased considerably, when estimating 2000, the diabetics number will break through 100,000,000 people in the world wide, and the major part of its increase is in developing country, and this does not obviously meet the epidemiologic feature of hereditary.A lot of nongenetic diseases have family's clustering phenomena (for example tuberculosis, hepatitis etc.), and same family member usually has identical living habit and living environment, and this just makes diabetes form a kind of nongenetic family clustering phenomena aspect epidemiology.Although people have exhausted effort, attempt in gene, to find the hereditism foundation relevant with diabetes, the result is always disappointing.

Insulin is considered to the hormone directly related with diabetes.Hypoinsulinism may be the main pathogenesis of insulin dependent diabetes mellitus (IDDM), and secretion of insulin more normally increases on the contrary for non-insulin-dependent diabetes mellitus.May there be number of mechanisms in the generation of this phenomenon explanation hyperglycemia, and the increase of insulin secretion may be the result of hyperglycemia and be not its reason.

Infer that theoretically the most direct reason that causes hyperglycemia is a digestive system to the infiltration rate of glucose greater than the accretion rate of body to glucose.Therefore, the pathogeny of research diabetes should be gone further investigation from digestive system and two aspects of hormonal system at least.Regrettably people often ignore the pathogeny of going to study diabetes from the angle of digestive system, just the result of the abnormal change of digestive system appearance as diabetes are gone to study on the contrary, and this obviously is to have occurred deviation on research direction.The dysfunction of digestive system fully can, and should as the cause of disease of diabetes go research.The present invention just is being based on this research generation.

The dysfunction of digestive system can cause diabetes, and this conclusion has abundant scientific basis.

Under physiological condition, it is by gastrointestinal tract the digestion and the absorption process of food to be finished that glucose enters body.Exist a kind of coupling relation of coordination between the digestion process of food, absorption process and body the demand, when the Shi Junke that gets muddled of any one process wherein causes carbohydrate metabolism disturbance to glucose.With the closely-related digestive system function disorder of the pathogeny of diabetes be the unusual of interdigestive migrating motor complex.

Interdigestive migrating motor complex is a kind of periodic propelling contractile motion that small intestinal takes place after gastric emptying, generally 4-6 hour ability takes place after dining, its function is to have digested in the small intestinal or the food of not catapepsis all enters proximal colonic, realizes the small intestinal emptying.As everyone knows, glucose is far longer than infiltration rate at colon in the infiltration rate of small intestinal.Glucose is absorbed into blood in a large number if glucose will cause in a short time in the prolongation of the small intestinal time of staying.The process of digesting and assimilating of food is not finished as yet within 4-6 hour after the meal, have only the small part glucose in 4-6 hour after the meal by the small intestinal fast Absorption.After interdigestive migrating motor complex took place, most of nutrient substance will be absorbed lentamente in proximal colonic, and this absorption process is sustainable more than 24 hours, and its physiological significance is to keep the relatively stable of blood glucose under starvation.For a long time, because people lack the extremely understanding of physiological function of dividing a word with a hyphen at the end of a line property of interdigestive phase compound motion, think that mistakenly the glucose major part is absorbed at small intestinal, too much glucose is that the form with hepatic glycogen is stored, and the decomposition of hepatic glycogen is to keep the constant relatively main mechanism of blood glucose under starvation.In fact hepatic glycogen generally can only be preserved 5 gram glucoses, and the back food of once having meal had only about 6 hours in the time of staying of small intestinal, fasting time reached about 12 hours after most of normal person's dinners, and hepatic glycogen not only is not consumed, and obtained synthetic and additional on the contrary.Hepatic glycogen just just is decomposed under stress state, so that a large amount of glucoses to be provided in a short time.Under non-stress state, because the effect of interdigestive migrating motor complex, make most of food be pushed to colon about 6 hours after the meal, proximal colonic has been preserved a large amount of glucoses and other nutrient substance, they are slowly absorbed equably, can keep the supply of human nutrition material for a couple of days at starvation.

Lack normal interdigestive migrating motor complex and can cause small intestinal emptying obstacle, make the food entrapment that has digested in a large number at small intestinal, most of glucose is rapidly absorbed into blood at small intestinal, and body is limited to the accretion rate of glucose, when the accretion rate of glucose just hyperglycemia can take place during less than the infiltration rate of glucose, unnecessary glucose is excreted and is taken away a large amount of body fluid by kidney, cause polydipsia polyuria and microcirculatory perfusion deficiency.Most of glucose and other nutrient substance have just lost proximal colonic to the gentle slow trapping process of the storage of nutrient substance after small intestinal is absorbed apace and excretes apace.At this moment, the concentration of blood glucose need rely on frequent feed and keep, thereby produces the symptom of easy hungry polyphagia, if prolong fasting time hypoglycemia just takes place easily.

Some important vitamines need the antibacterial of colon synthetic.Because most of nutrient substance is finished by metabolism at small intestinal, colon bacteria lacks the supply of nutrient substance, intestinal bacteria quantity is reduced, and then cause vitamin deficiency (especially vitamin B group shortage), this is the important foundation that produces the nervous system complication, also is simultaneously one of reason that takes place constipation.

The synthetic of human body protein is a process relatively slowly, and aminoacid adapts with it in the slow absorption process of colon.If the protein in the food is at the small intestinal overstand, be decomposed into aminoacid fully and fast Absorption is gone into blood, will cause the speed of the speed of momentary aminoacid absorption greater than protein synthesis, and aminoacid can not store, can only excrete fast, thereby increase the weight of the kidney burden, even cause renal damage.Because exogenous aminoacid time of staying in blood shortens, cause that protein utilization descends in the food, this be produce become thin, major reason that immunologic function degression and wound are difficult for healing.

The common cause that causes small intestinal emptying obstacle is unsuitable feed.Dining behavior before dividing a word with a hyphen at the end of a line property compound motion does not take place as yet for the first time after the meal can stop dividing a word with a hyphen at the end of a line property compound motion, causes food to be detained at small intestinal.

Reasonably meal time should be after dividing a word with a hyphen at the end of a line property compound motion takes place.Yet deep variation has taken place in the weather of human society since the nearly century.Not only eliminated hunger in developed country, and people are growing to the pursuit of material life, various ticbits are being tempted people's appetite, contacts between the people and dinner party are usually come into contacts with dining table, bar, and people's dining activity has exceeded the required category of surviving.The human active variation of this dining is the major reason that causes small intestinal emptying obstacle.Sickness rate in the country of poverty and outlying rural area diabetes is starkly lower than developed country and big city, and this is different closely related with dietary habit.Every day breakfast, lunch and dinner custom and do not meet human psychological need.Because the blanking time of breakfast and lunch is less than 6 hours usually, cause small intestinal emptying obstacle easily.In addition, people usually have unsuitable feed behavior between two meal, and this also is the major reason that causes small intestinal emptying obstacle.

Hunger is many mammiferous physiological neeies, and is human no exception.The survival and development in the process of struggling of many species with hunger.The appearance of interdigestive migrating motor complex is exactly a kind of physiological function of the opposing hunger that produces during evolution of wild animal, and it can make the food after wild animal is once had meal in a large number slowly and equably be absorbed.Like this, both can keep the constant relatively of blood glucose, can resist the hunger of long period again.The mankind try hard to eliminate hungry, and become a reality in many developed countries, but diabetes but are widely current in these countries, and the cardiovascular and cerebrovascular disease relevant with diabetes also becomes serious day by day health problem in these countries.Obviously, human animal species of having meal as an interruption can not lack " hunger " a kind of so physiological stimulation equally, just should suitably give this stimulation from neonate.This stimulation can make the people set up the cyclic activity of normal interdigestive migrating motor complex, improves human body anti-hunger ability and prevents the generation of diabetes effectively.If lack hungry stimulation period at infant, just can not set up the cyclic activity of normal interdigestive migrating motor complex, cause food to prolong in the small intestinal time of staying.

Food causes glucose absorption to speed up in the prolongation of the small intestinal time of staying can cause that insulin secretion and release increase, and hyperinsulinemia occurs.Owing to the existence of hyperinsulinemia, blood glucose can remain on normal range over a period to come, but hyperinsulinemia is enough to cause a series of organism metabolic disorders, wherein most importantly lipometabolic disorder.Obesity, hyperlipemia, vascular hypertension, atherosclerosis and the cardiovascular and cerebrovascular disease that takes place have on this basis spreaded all over All Around The World at present.These diseases and diabetes occurred in for 20th century simultaneously, and often were accompanied, and this never is accidental coincidence, but the result that same reason causes.

It is a universal phenomenon that diabetics merges gastrointestinal dysfunction, is called as diabetic gastroparesis in the literature, and its principal character is that gastric emptying delays, and its pathogeny it be unclear that, and majority think that the autonomic neuropathy that causes with diabetes is relevant.But, if small intestinal emptying obstacle and gastric emptying are delayed to connect the pathogeny that just is understood that diabetic gastroparesis.Because food must cause the emptying obstacle of stomach in the delay of small intestinal.

Because people make the pathogeny of diabetes can not get correct understanding to the inspection method that the motor function and the absorption process of small intestinal lacks clinical practice.In order fundamentally to cure diabetes, a correct understanding must be arranged the pathogeny of diabetes, formulate therapeutic scheme at its pathogeny.Above-mentionedly systematically summarized the cause of disease, pathogenesis of diabetes and the principle that complication produces thereof about the gastrointestinal source hypothesis of onset diabetes mechanism comprehensively, simultaneously pragmatize the reasons that produce of the epidemiology characteristics of diabetes on time and Regional Distribution.The present invention just is being based on this theoretical generation.

The basic skills of treatment diabetes is to recover patient normal gastrointestinal function, especially interdigestive migrating motor complex.It comprises pharmacotherapy and non-drug therapy, and wherein non-drug therapy is the most basic, also is simple, the most effective Therapeutic Method.

Diet control is the key component of non-drug therapy.Logical diet control not only is the restriction of food total amount, the more important thing is the grasp of meal time, so that interdigestive migrating motor complex can successfully be taken place.How to carry out diet control for people are understood, be necessary the mechanism that dividing a word with a hyphen at the end of a line property of interdigestive phase compound motion takes place is set forth:

Human body approximately had 9 liters of Digestive systems in per 24 hours by duodenum, and they are from salivary gland, gastric gland, duodenal gland, pancreas and liver and gall external secretion system.These secretion of digestive juice activities do not stop at interdigestive phase (after the gastric emptying).In addition, superior mesenteric artery is arranged by causing the physiological compressing, make distal duodenum keep certain resistance, and be closure state as a rule at the intersection of duodenum and jejunum.And pylorus keeps open state at interdigestive phase.Duodenal anatomic characteristic be the c-shaped back of a bow backward, hold head of pancreas.Therefore, no matter human body is in upright position or clinostatism, Digestive system always can successfully flow into duodenum, but is difficult to rely on action of gravity to make Digestive system flow into jejunum under the situation of propelling property wriggling not, and this has just caused the physiological duodenum retention of interdigestive phase.When duodenum retention liquid reaches a certain amount of, will bring out dividing a word with a hyphen at the end of a line property compound motion, retention liquid (wherein containing multiple digestive enzyme) is pushed to proximal colonic by stretch reflex, with the there as yet not the food of catapepsis mix, further finish digestion process.This dividing a word with a hyphen at the end of a line property compound motion took place once at the every 1-2 of interdigestive phase hour, presented a kind of periodic gastrointestinal motility, and this cyclic activity shows particularly outstandingly at night.In case the feed activity begins, this cyclic activity is just upset, and could recover after 4-6 hour.

Diabetics is because a large amount of body fluid is lost the infringement that causes digestive juice secretion minimizing and autonomic nerve, be difficult in 1-2 hour, bring out interdigestive migrating motor complex by stretch reflex, make a large amount of foods rest on small intestinal for a long time, glucose absorption is speeded up, blood glucose increases, further increase the weight of body fluid and lose, form vicious cycle, increase the weight of diabetes.Must use the generation of medicine facilitating digestion dividing a word with a hyphen at the end of a line property of interval compound motion regularity just can interrupt vicious cycle in this case, fundamentally cure diabetes.Therefore, the effective Therapeutic Method of diabetes made the patient that interdigestive migrating motor complex takes place one time exactly in 4-6 hour after the meal, made the food of small intestinal enter proximal colonic.

Some promote the medicine of digestive tract power to come out one after another in recent years, as dompendone, metoclopramide, cisapride etc., but do not find that they have the effect of facilitating digestion dividing a word with a hyphen at the end of a line property of interval compound motion.Erythromycin is considered to the agonist (motilin is considered to and the closely-related gut hormone of interdigestive migrating motor complex at present) of motilin receptor, but its site of action mainly is at stomach, rather than at small intestinal.In addition, the secretion that these medicines can not facilitating digestion liquid can not recover the normal rhythm of physiological interdigestive migrating motor complex.

The objective of the invention is to create a kind of method of new treatment diabetes and find a kind of medicine of the cause of disease and the pathogeny treatment diabetes at diabetes, make diabetes really become a kind of disease that can cure.

The specific embodiments that realizes above-mentioned purpose is as follows:

1, correctly selects meal time: should make once normal interdigestive migrating motor complex generation between two meal.For reaching this purpose, int cib is being every being advisable more than 7 hours, and advocates meal every days two.

2, reasonably replenish body fluid: diabetics body fluid is lost more, and digestive juice secretion is reduced, and causes interdigestive migrating motor complex generation retard.Therefore, suitably drank tea at 2 hours after the meal or drink water and help remedying the deficiency of digestive juice secretion and the generation of facilitating digestion dividing a word with a hyphen at the end of a line property of interval compound motion.

3, use the generation of medicine facilitating digestion dividing a word with a hyphen at the end of a line property of interval compound motion: the pharmaceutical formulation that can facilitating digestion dividing a word with a hyphen at the end of a line property of interval compound motion takes place that the present invention proposes comprises two kinds of Chinese medicine ingredients, Radix Et Rhizoma Rhei and Radix Glycyrrhizaes.Compound method is as follows:

Press the crude drug weight ratio, get 2 parts of Radix Et Rhizoma Rhei, 1 part in Radix Glycyrrhizae is boiled with decocting, filters, and simmer down to is equivalent to per 10 milliliters of oral liquids that contain Radix Et Rhizoma Rhei 2 gram Radix Glycyrrhizaes 1 gram, with every 10 milliliters of sterile packaged.

Using method: took 1-2 in 2 hours after the meal and prop up.

Its function is to promote the generation of interdigestive migrating motor complex after the meal.

Radix Et Rhizoma Rhei has the effect that strengthens gastrointestinal motility and promote bile secretion, and the drug effect performance is rapid and strong, is commonly used to treat constipation, acute pancreatitis clinically, cholecystitis and cholelithiasis etc.Radix Et Rhizoma Rhei is mainly got its effect that promotes bile secretion in being used for the treatment of diabetes.

Biliary secretion can be brought out interdigestive migrating motor complex.The characteristics that take place according to interdigestive migrating motor complex generally were divided into it for 3 phases: 1 phase was a stage of latency, did not have or seldom have contraction movement; The irregular contraction movement that 2 phases can occur being interrupted; 3 phases were made up of a kind of intensive contraction movement of continuous appearance, and its contraction frequency about 3 times/minute at gastric antrum is about 11 times/minute of duodenum and jejunum.Have only 3 phase contraction movements small intestine contents could be pushed to proximal colonic.Modern studies show that, in 3 phases the preceding peak that usually occurred bile secretion and discharging in about 20 minutes takes place.A large amount of bile enter duodenum can stimulate the duodenal mucosa chemoreceptor, causes that by neural reflex (comprise speed walk nerve and enteric nervous system) pancreas, duodenal gland secretory activity strengthen; Can cause also that simultaneously some gut hormone secretory activities strengthen (as motilin etc.).Thus, make in a short time and assembled a large amount of Digestive systems in the duodenum, make duodenal wall be subjected to stretching.Because the excretory increase of motilin promotes the wriggling of stomach also to make sphincters contract under the esophagus, so a large amount of gastric juice that is stored at the bottom of the stomach also enters duodenum.The intestinal juice of tart gastric juice and alkalescence mixes fully at duodenum, just can bring out the contraction movement of 3 phases when duodenal juice is increased to the 300-400 milliliter.Therefore, use Radix Et Rhizoma Rhei can bring out interdigestive migrating motor complex.

Radix Glycyrrhizae is a kind of Chinese herbal medicine commonly used, has pharmacological action widely.Using Radix Glycyrrhizae among the present invention mainly is to utilize it to the protective effect of gastric mucosa with to the spasmolysis of gastrointestinal smooth muscle, can also alleviate the high strong catharsis effect of Radix Et Rhizoma Rhei simultaneously, so that life-time service and do not produce bigger side effect.

Advantage of the present invention is:

1, treats diabetes at the pathogeny of diabetes, thereby can produce definite therapeutic effect.The metabolism disorder that diabetes cause is many-sided, merely glycemic control can not fundamentally be alleviated the metabolism disorder of others in normal range.Therefore, can not be with blood glucose whether normally as unique index of estimating therapeutic effect.The Therapeutic Method that generally adopts is by oral antidiabetic drug (mainly being sulphanylureas and biguanides) and insulin injection blood sugar control at present, although these methods are effectively, can not fundamentally cure diabetes.Above-mentioned gastrointestinal source theory about onset diabetes mechanism is basis of the present invention.By adjusting gastrointestinal function, make the infiltration rate homogenization of glucose, then be hopeful to make diabetes to obtain basic treatment.

2, toxic and side effects is little, and is easy to use, with low cost.The present invention adopts nontoxic pure natural plant as basis, has improved the safety of using greatly.Overcome the shortcoming that biguanides and sulphanylureas oral antidiabetic drug easily produce toxic and side effects such as hypoglycemia, disorders of lipid metabolism, hepatic renal dysfunction.It is easy to use to make oral agents, can directly act on gastrointestinal tract, rapid-action, has overcome injection of insulin and has used inconvenient shortcoming.Two kinds of Chinese herbal medicine commonly used of Radix Et Rhizoma Rhei and Radix Glycyrrhizae are cheap, and the medicine source is abundant.In today that the onset diabetes rate increases day by day, the people needs the medicine of effective and cheap treatment diabetes more.

In sum, diabetes are a kind of diseases relevant with the gastrointestinal motility function.Under normal circumstances, most of glucose is slowly with absorbed equably in proximal colonic.Because people's dietary habit and living condition's change causes the shortage of interdigestive migrating motor complex, food prolonged in the small intestinal time of staying, make most of glucose at small intestinal by fast Absorption, this is the pathogenetic main cause of glycosuria.By recovering normal interdigestive migrating motor complex, can make this disease obtain basic treatment.The present invention has not only found a kind of medicine and method for treatment of diabetes, the more important thing is the pathogeny and the physiological action of interdigestive migrating motor complex in regulating the absorption of nutrient ingredients process that have fundamentally disclosed diabetes.The greatness achievement of this preclinical medicine aspect will be opened up more wide research field for the development of human medical career.

Claims (3)

1, a kind of medicine for the treatment of diabetes is characterized in that: become to be grouped into by two kinds of natural Chinese medicinal herb of Radix Et Rhizoma Rhei and Radix Glycyrrhizae.

2, the compound method of the described medicine of claim 1 is characterized in that: press the crude drug weight ratio, get 2 parts of Radix Et Rhizoma Rhei, 1 part in Radix Glycyrrhizae is boiled with decocting, filters, and concentrates, and sterile packaged becomes oral liquid.

3, the medicine that takes place of a kind of facilitating digestion dividing a word with a hyphen at the end of a line property of interval compound motion is characterized in that: meet the feature of claim 1 or meet the feature of claim 2.